Ernest Hodgson

Lawrie, R. D., Mitchell, R. D., III, Dhammi, A., Wallace, A., Hodgson, E., & Roe, R. M. (2020). Role of long non-coding RNA in DEET- and fipronil-mediated alteration of transcripts associated with Phase I and Phase II xenobiotic metabolism in human primary hepatocytes. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 167. https://doi.org/10.1016/j.pestbp.2020.104607

Mitchell, R. D., III, Wallace, A. D., Hodgson, E., & Roe, R. M. (2017). Differential Expression Profile of lncRNAs from Primary Human Hepatocytes Following DEET and Fipronil Exposure. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(10). https://doi.org/10.3390/ijms18102104

Mitchell, R. D., III, Dhammi, A., Wallace, A., Hodgson, E., & Roe, R. M. (2016). Impact of Environmental Chemicals on the Transcriptome of Primary Human Hepatocytes: Potential for Health Effects. Journal of Biochemical and Molecular Toxicology, 30(8), 375–395. https://doi.org/10.1002/jbt.21801

Hodgson, E., Wallace, A. D., Shah, R. R., Choi, K., & Joo, H. (2014). Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 28(1), 1–10. https://doi.org/10.1002/jbt.21534

Hodgson, E. (2012). [Review of Human environments: Definition, scope, and the role of toxicology]. Toxicology and human environments, 112, 1–10.

Hodgson, E. (2012). [Review of Metabolic interactions of environmental toxicants in humans]. Toxicology and human environments, 112, 349–372.

Pesticide biotransformation and disposition. (2012). Waltham, MA: Academic Press.

Hodgson, E. (2012). Progress in molecular biology and translational science toxicology and human environments summary and conclusions. Toxicology and Human Environments, 112, 417–421.

Hodgson, E. (2012). [Review of The future of human health risk assessment of environmental chemicals]. Toxicology and human environments, 112, 307–322.

Hodgson, E. (2012). [Review of Toxins and venoms]. Toxicology and human environments, 112, 373–415.

Joo, H., Choi, K., & Hodgson, E. (2010). Human metabolism of atrazine. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 98(1), 73–79. https://doi.org/10.1016/j.pestbp.2010.05.002

Croom, E. L., Wallace, A. D., & Hodgson, E. (2010). Human variation in CYP-specific chlorpyrifos metabolism. TOXICOLOGY, 276(3), 184–191. https://doi.org/10.1016/j.tox.2010.08.005

Croom, E. L., Stevens, J. C., Hines, R. N., Wallace, A. D., & Hodgson, E. (2009). Human hepatic CYP2B6 developmental expression: The impact of age and genotype. BIOCHEMICAL PHARMACOLOGY, 78(2), 184–190. https://doi.org/10.1016/j.bcp.2009.03.029

Hodgson, E., & Rose, R. L. (2008, June). Metabolic interactions of agrochemicals in humans. PEST MANAGEMENT SCIENCE, Vol. 64, pp. 617–621. https://doi.org/10.1002/ps.1563

Hodgson, E., & Rose, R. L. (2007). Human metabolic interactions of environmental chemicals. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, Vol. 21, pp. 182–186. https://doi.org/10.1002/jbt.20175

Joo, H., Choi, K., Rose, R. L., & Hodgson, E. (2007). Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 21(2), 76–80. https://doi.org/10.1002/jbt.20161

Hodgson, E., & Rose, R. L. (2007). [Review of The importance of cytochrome P4502B6 in the human metabolism of environmental chemicals]. PHARMACOLOGY & THERAPEUTICS, 113(2), 420–428. https://doi.org/10.1016/j.pharmthera.2006.10.002

Das, P. C., Cao, Y., Cherrington, N., Hodgson, E., & Rose, R. L. (2006, December 15). Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes. CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 164, pp. 200–214. https://doi.org/10.1016/j.cbi.2006.09.013

Usmani, K. A., Cho, T. M., Rose, R. L., & Hodgson, E. (2006, September). Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals. DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 1606–1614. https://doi.org/10.1124/dmd.106.010439

Choi, K., Joo, H., Rose, R. L., & Hodgson, E. (2006). Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes. Journal of Biochemical and Molecular Toxicology, 20(6), 279–291. https://doi.org/10.1002/jbt.20145

Casabar, R. C. T., Wallace, A. D., Hodgson, E., & Rose, R. L. (2006, October). Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4. DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 1779–1785. https://doi.org/10.1124/dmd.106.010199

Kavlock, R., Barr, D., Boekelheide, K., Breslin, W., Breysse, P., Chapin, R., … Williams, P. (2006). [Review of NTP-CERHR Expert Panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate]. Reproductive Toxicology (Elmsford, N.Y.), 22(3), 291–399.

Hodgson, E., & Rose, R. L. (2006). [Review of Organophosphorus chemicals: Potent inhibitors of the human metabolism of steroid hormones and xenobiotics]. DRUG METABOLISM REVIEWS, 38(1-2), 149–162. https://doi.org/10.1080/03602530600569984

Brimfield, A. A., Novak, M. J., & Hodgson, E. (2006). Thiodiglycol, the hydrolysis product of sulfur mustard: Analysis of in vitro biotransformation by mammalian alcohol dehydrogenases using nuclear magnetic resonance. TOXICOLOGY AND APPLIED PHARMACOLOGY, 213(3), 207–215. https://doi.org/10.1016/j.taap.2005.11.009

Hodgson, E., & Rose, R. L. (2005). [Review of Human metabolism and metabolic interactions of deployment-related chemicals]. DRUG METABOLISM REVIEWS, 37(1), 1–39. https://doi.org/10.1081/DMR-200046955

Cho, T. M., Rose, R. L., & Hodgson, E. (2006, January). In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes. DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 176–183. https://doi.org/10.1124/dmd.105.005785

Alavanja, M. C. R., Bonner, M. R., Furlong, C. E., Allen, R., & Hodgson, E. (2005). Molecular Biomarker Workshop - Agricultural Health Study - Discussion and conclusions. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 19(3), 192–193. https://doi.org/10.1002/jbt.20083

Rose, R. L., & Hodgson, E. (2005). Pesticide metabolism and potential for metabolic interactions. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 19(4), 276–277. https://doi.org/10.1002/jbt.20077

Rose, R. L., Tang, J., Choi, J., Cao, Y., Usmani, A., Cherrington, N., & Hodgson, E. (2005). Pesticide metabolism in humans, including polymorphisms. Scandinavian Journal of Work, Environment & Health, 31, 156–163.

Edwards, J. E., Rose, R. L., & Hodgson, E. (2005). The metabolism of nonane, a JP-8 jet fuel component, by human liver microsomes, P450 isoforms and alcohol dehydrogenase and inhibition of human P450 isoforms by JP-8. CHEMICO-BIOLOGICAL INTERACTIONS, 151(3), 203–211. https://doi.org/10.1016/j.cbi.2004.12.003

Hodgson, E., & Rose, R. L. (2005). Toxicology of AHS important chemicals. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 19(3), 180–181. https://doi.org/10.1002/jbt.20076

Usmani, K. A., Hodgson, E., & Rose, R. L. (2004). In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol. CHEMICO-BIOLOGICAL INTERACTIONS, 150(3), 221–232. https://doi.org/10.1016/j.cbi.2004.09.015

Tang, J., Usmani, K. A., Hodgson, E., & Rose, R. L. (2004). In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam. CHEMICO-BIOLOGICAL INTERACTIONS, 147(3), 319–329. https://doi.org/10.1016/j.cbi.2004.03.002

Usmani, K. A., Karoly, E. D., Hodgson, E., & Rose, R. L. (2004). In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily. DRUG METABOLISM AND DISPOSITION, 32(3), 333–339. https://doi.org/10.1124/dmd.32.3.333

Thompson, D. M., Young, H. P., Edens, F. W., Olmstead, A. W., LeBlanc, G. A., Hodgson, E., & Roe, R. M. (2004). Non-target toxicology of a new mosquito larvicide, trypsin modulating oostatic factor. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 80(3), 131–142. https://doi.org/10.1016/j.pestbp.2004.06.009

Hodgson, E. (2003). In vitro human phase I metabolism of xenobiotics I: Pesticides and related compounds used in agriculture and public health, May 2003. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 17(4), 201–206. https://doi.org/10.1002/jbt.10080

Usmani, K. A., Rose, R. L., & Hodgson, E. (2003). Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals. DRUG METABOLISM AND DISPOSITION, 31(4), 384–391. https://doi.org/10.1124/dmd.31.4.384

Usmani, K. A., Rose, R. L., Goldstein, J. A., Taylor, W. G., Brimfield, A. A., & Hodgson, E. (2002). In vitro human metabolism and interactions of repellent N,N-diethyl-M-toluamide. DRUG METABOLISM AND DISPOSITION, 30(3), 289–294. https://doi.org/10.1124/dmd.30.3.289

Choi, J., Rose, R. L., & Hodgson, E. (2002). In vitro human metabolism of permethrin: the role of human alcohol and aldehyde dehydrogenases. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 74(3), 117–128. https://doi.org/10.1016/S0048-3575(02)00154-2

Tang, J., Cao, Y., Rose, R. L., & Hodgson, E. (2002). In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos. CHEMICO-BIOLOGICAL INTERACTIONS, 141(3), 229–241. https://doi.org/10.1016/S0009-2797(02)00074-1

Dai, D., Bai, R., Hodgson, E., & Rose, R. L. (2001). Cloning, sequencing, heterologous expression, and ch;characterization of murine cytochrome p450 3a25*(Cyp3a25), a testosterone 6 beta-hydroxylase. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 15(2), 90–99. https://doi.org/10.1002/jbt.4

Hodgson, E. (2001). Genetically modified plants and human health risks: Can additional research reduce uncertainties and increase public confidence? TOXICOLOGICAL SCIENCES, 63(2), 153–156. https://doi.org/10.1093/toxsci/63.2.153

Dai, D., Tang, J., Rose, R., Hodgson, E., Bienstock, R. J., Mohrenweiser, H. W., & Goldstein, J. A. (2001). Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. Journal of Pharmacology and Experimental Therapeutics, 299(3), 825–831.

Hodgson, E. (2001). In vitro human phase I metabolism of xenobiotics I: Pesticides and related chemicals used in agriculture and public health, September 2001. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 15(6), 296–299. https://doi.org/10.1002/jbt.10011

Tang, J., Cao, Y., Rose, R. L., Brimfield, A. A., Dai, D., Goldstein, J. A., & Hodgson, E. (2001). Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes. Drug Metabolism and Disposition, 29(9), 1201–1204.

Dai, D., Cao, Y., Falls, G., Levi, P. E., Hodgson, E., & Rose, R. L. (2001). Modulation of mouse P450 isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the environmental chemicals mirex, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene, vinclozolin, and flutamide. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 70(3), 127–141. https://doi.org/10.1006/pest.2001.2551

Coleman, S., Linderman, R., Hodgson, E., & Rose, R. L. (2000). Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes. ENVIRONMENTAL HEALTH PERSPECTIVES, 108(12), 1151–1157. https://doi.org/10.2307/3434827

Roe, R. M., Bailey, W. D., Gould, F., Sorenson, C. E., Kennedy, G. G., Bacheler, J. S., … Sutula, C. L. (2000). Detection of resistant insects and IPM. Emerging Technologies for Integrated Pest Management : Concepts, Research, and Implementation, 67.

Hodgson, E., Rose, R. L., Cao, Y., Dehal, S. S., & Kupfer, D. (2000). Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidation. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 14(2), 118–120. https://doi.org/10.1002/(SICI)1099-0461(2000)14:2<118::AID-JBT8>3.0.CO;2-T

Gray, G. M., Goldstein, B. D., Bailar, J., Davis, D. L., Delzell, E., Dost, F., … Graham, J. S. (2000). The federal government's Agricultural Health Study: A critical review with suggested improvements. HUMAN AND ECOLOGICAL RISK ASSESSMENT, 6(1), 47–71. https://doi.org/10.1080/10807030091124446

Ryu, D. Y., & Hodgson, E. (1999). Constitutive expression and induction of CYP1B1 mRNA in the mouse. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 13(5), 249–251. https://doi.org/10.1002/(SICI)1099-0461(1999)13:5<249::AID-JBT4>3.0.CO;2-L

Coleman, S., Liu, S. M., Linderman, R., Hodgson, E., & Rose, R. L. (1999, August 30). In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms. CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 122, pp. 27–39. https://doi.org/10.1016/S0009-2797(99)00107-6

Hodgson, E. (1999). Induction and inhibition of pesticide-metabolizing enzymes: roles in synergism of pesticides and pesticide action. TOXICOLOGY AND INDUSTRIAL HEALTH, 15(1-2), 6–11. https://doi.org/10.1177/074823379901500102

Roe, R. M., Hodgson, E., Rose, R. L., Thompson, D. M., Devorshak, C., Anspaugh, D. D., … Tomalski, M. D. (1998). Basic principles and rationale for the use of insect genes in bioremediation: esterases, phosphotriesterase, cytochrome P450 and epoxide hydrolase. Reviews in Toxicology, 2(1998), 169–178.

Luo, G., Zeldin, D. C., Blaisdell, J. A., Hodgson, E., & Goldstein, J. A. (1998). Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 357(1), 45–57. https://doi.org/10.1006/abbi.1998.0806

Mileson, B. E., Chen, W. L., Dettbarn, W., Ehrich, M., Eldefrawi, A. T., Gaylor, D. W., … Wallace, K. B. (1998). Common mechanism of toxicity: A case study of organophosphorus pesticides. Fundamental and Applied Toxicology, 41(1), 8–20.

Hodgson, E., Mailman, R. B., Chambers, J. E., & Dow, R. E. (1998). Dictionary of toxicology (2nd ed.). London: MacMillan Reference; New York: Grove Dictionaries.

Hodgson, E., Cherrington, N., Coleman, S. C., Liu, S., Falls, J. G., Cao, Y., … Rose, R. L. (1998). Flavin-containing monooxygenase and cytochrome P450 mediated metabolism of pesticides: from mouse to human. Reviews in Toxicology, 2(1998), 231–243.

Cherrington, N. J., Falls, J. G., Rose, R. L., Clements, K. M., Philpot, R. M., Levi, P. E., & Hodgson, E. (1998). Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5). Journal of Biochemical and Molecular Toxicology, 12(1998), 205–212. https://doi.org/10.1002/(sici)1099-0461(1998)12:4<205::aid-jbt2>3.3.co;2-4

Cherrington, N. J., Cao, Y., Cherrington, J. W., Rose, R. L., & Hodgson, E. (1998). Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5. XENOBIOTICA, 28(7), 673–682. https://doi.org/10.1080/004982598239254

Rose, R. L., Goh, D., Thompson, D. M., Verma, K. D., Heckel, D. G., Gahan, L. J., … Hodgson, E. (1997). Cytochrome P450 (CYP)9A1 in Heliothis virescens: The first member of a new CYP family. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 27(6), 605–615. https://doi.org/10.1016/S0965-1748(97)00036-2

Falls, J. G., Cherrington, N. J., Clements, K. M., Philpot, R. M., Levi, P. E., Rose, R. L., & Hodgson, E. (1997). Molecular cloning, sequencing, and expression in Escherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): Comparison with the human isoform. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 347(1), 9–18. https://doi.org/10.1006/abbi.1997.0322

Ryu, D. Y., Levi, P. E., & Hodgson, E. (1997). Regulation of hepatic CYP1A isozymes by piperonyl butoxide and acenaphthylene in the mouse. CHEMICO-BIOLOGICAL INTERACTIONS, 105(1), 53–63. https://doi.org/10.1016/S0009-2797(97)00035-5

Falls, J. G., Ryu, D. Y., Cao, Y., Levi, P. E., & Hodgson, E. (1997, June 15). Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 342, pp. 212–223. https://doi.org/10.1006/abbi.1997.9965

Hodgson, E., & Levi, P. E. (1997). Textbook of modern toxicology. Stamford, Conn.: Appleton & Lange.

Roe, R., Hodgson, E., & Rose, R. (1996). Insecticide resistance associated cytochrome 450. Washington, DC: U.S. Patent and Trademark Office.

Hodgson, E., Rose, R. L., Ryu, D. Y., Falls, G., Blake, B. L., & Levi, P. E. (1995, December). Pesticide-metabolizing enzymes. TOXICOLOGY LETTERS, Vol. 82-3, pp. 73–81. https://doi.org/10.1016/0378-4274(95)03469-2

VENKATESH, K., LEVI, P. E., INMAN, A. O., MONTEIRORIVIERE, N. A., MISRA, R., & HODGSON, E. (1992). ENZYMATIC AND IMMUNOHISTOCHEMICAL STUDIES ON THE ROLE OF CYTOCHROME-P450 AND THE FLAVIN-CONTAINING MONOOXYGENASE OF MOUSE SKIN IN THE METABOLISM OF PESTICIDES AND OTHER XENOBIOTICS. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 43(1), 53–66. https://doi.org/10.1016/0048-3575(92)90019-V

Hodgson, E., Motoyama, N., Evered, D., & Collins, G. M. (1984). Biochemical mechanisms of resistance to insecticides. In Origins and development of adaptation (p. 167). London: Pitman.

Hodgson, E., Kulkarni, A. P., Georghiou, G. P., & Saito, T. (1983). Characterization of cytochrome P-450 in studies of insecticide resistance. In G. P. Georghiou & T. Saito (Eds.), Pest resistance to pesticides (p. 207). New York: Plenum Press.

HODGSON, E. (1983). [Review of THE SIGNIFICANCE OF CYTOCHROME-P-450 IN INSECTS]. INSECT BIOCHEMISTRY, 13(3), 237–246. https://doi.org/10.1016/0020-1790(83)90044-6

HODGSON, E., LIGON, B. G., & ROCK, G. C. (1977). SUBSTITUTION OF CHOLINE BY RELATED COMPOUNDS IN DIET OF ARGYROTAENIA-VELUTINANA AND HELIOTHIS-VIRESCENS. JOURNAL OF INSECT PHYSIOLOGY, 23(7), 801–804. https://doi.org/10.1016/0022-1910(77)90002-6

HODGSON, E., TATE, L. G., KULKARNI, A. P., & PLAPP, F. W. (1974). MICROSOMAL CYTOCHROME-P-450 - CHARACTERIZATION AND POSSIBLE ROLE IN INSECTICIDE RESISTANCE IN MUSCA-DOMESTICA. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Vol. 22, pp. 360–366. https://doi.org/10.1021/jf60193a027