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Works (18)
Updated: April 5th, 2024 04:07
2023 journal article
Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: <i>in vitro</i> screening assays
Journal of Toxicology and Environmental Health, Part B, 5, 1–35.
author keywords: Sucralose; sucralose-6-acetate; genotoxicity; gene expression; intestinal barrier
TL;DR:
Measurements of transepithelial electrical resistance (TEER) and permeability in human transverse colon epithelium indicated that sucralose-6-acetate and Sucralose both impaired intestinal barrier integrity.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 12, 2023
2022 journal article
A resource for integrated genomic analysis of the human liver
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Bayes Theorem; Genome-Wide Association Study / methods; Genomics; Humans; Liver; Polymorphism, Single Nucleotide; Quantitative Trait Loci
TL;DR:
This study generated whole-transcriptome RNA-Seq from genotyped liver samples and used existing data from the GTEx Project and previous liver eQTL studies to create an enhanced transcriptomic sequence resource in the human liver, finding that MHC genes, and especially class II genes, are enriched for liver-specific eZTL patterns.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 8, 2022
2022 journal article
The Genome of the Poecilogonous Annelid Streblospio benedicti
GENOME BIOLOGY AND EVOLUTION, 14(2).
Ed(s): D. Lavrov
author keywords: poecilogony; life-history evolution; developmental genomics; Lophotrochozoa
MeSH headings : Animals; Annelida / genetics; Larva / genetics; Phylogeny; Polychaeta / genetics; Sequence Analysis, DNA
TL;DR:
An annotated chromosomal-level genome assembly of S. benedicti is presented, which is the largest annelid genome to date that has been assembled to chromosomal scaffolds, yet it does not show evidence of extensive gene family expansion, but rather longer intergenic regions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 25, 2022
2021 journal article
Genome and transcriptome sequencing of the green bottle fly, Lucilia sericata, reveals underlying factors of sheep flystrike and maggot debridement therapy
Genomics, 113(6), 3978–3988.
author keywords: Lucilia sericata; Maggot debridement therapy; Whole genome; Salivary gland; Malpighian tubule; Heat shock
MeSH headings : Animals; Calliphoridae; Debridement; Diptera / genetics; Humans; Larva / genetics; Larva / metabolism; Sheep / genetics; Transcriptome
TL;DR:
The assembly of a 565.3 Mb genome from long read PacBio DNA sequencing of genomic DNA is reported, which will underpin future genetic studies and in development of engineered strains for genetic control of L. sericata and for biotechnology-enhanced maggot therapy.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: October 26, 2021
2021 article
High-resolution characterization of the structural features and genetic variation of six feline leukocyte antigen class I loci via single molecule, real-time (SMRT) sequencing
Holmes, J. C., Scholl, E. H., Dickey, A. N., & Hess, P. R. (2021, June 27). IMMUNOGENETICS, Vol. 6.
author keywords: Cats; Class I genes; High-throughput DNA sequencing; Major histocompatibility complex; Polymorphism
MeSH headings : Animals; Cats; Exons; Genes, MHC Class I / genetics; Genetic Variation; Haplotypes; High-Throughput Nucleotide Sequencing; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Sequence Analysis, DNA / methods
TL;DR:
A targeted approach to FLAI genotyping, using the single-molecule real-time (SMRT) platform, which allows full-length (3.4-kb) reads without assembly, is developed, which could allow highly accurate allele surveys in large cat cohorts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021
2020 journal article
Complete Genome Sequences of Six Lactobacilli Isolated from American Quarter Horses
MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 9(47).
Ed(s): D. Rasko
TL;DR:
The complete circular genome sequences of six Lactobacillus strains and their plasmids, if any, from the fecal material of quarter horses at different ages are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 4, 2021
2020 journal article
Genomic analyses of a livestock pest, the New World screwworm, find potential targets for genetic control programs
Communications Biology, 3(1).
MeSH headings : Animals; Calliphoridae / genetics; Calliphoridae / pathogenicity; Evolution, Molecular; Gene Expression Regulation / genetics; Genomics / methods; Host-Parasite Interactions / genetics; Larva / genetics; Larva / growth & development; Livestock / genetics; Livestock / parasitology; Pest Control, Biological; RNA-Seq; Screw Worm Infection / genetics; Screw Worm Infection / parasitology; South America
TL;DR:
The genome of the New World screwworm is reported, using transcriptomic analysis of the insect’s developmental stages combined with genomic analyses to identify genes that may be important for its parasitic lifestyle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: September 7, 2020
2018 journal article
Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp nov.
SYSTEMATIC AND APPLIED MICROBIOLOGY, 41(5), 460–472.
author keywords: Acidovorax; Phenanthrene; Polycyclic aromatic hydrocarbons
MeSH headings : Biodegradation, Environmental; Comamonadaceae / chemistry; Comamonadaceae / classification; Comamonadaceae / genetics; Comamonadaceae / physiology; DNA, Bacterial; Genes, Bacterial; Genome, Bacterial / genetics; Metabolic Networks and Pathways / genetics; North Carolina; Phenanthrenes / metabolism; Phylogeny; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; Soil Pollutants / metabolism
TL;DR:
Four bacterial strains identified as members of the Acidovorax genus were isolated from two geographically distinct but similarly contaminated soils in North Carolina, USA, characterized, and their genomes sequenced, indicating that they likely represent a single species within the genus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
Population genetic diversity in zebrafish lines
MAMMALIAN GENOME, 29(1-2), 90–100.
Contributors: M. Balik-Meisner n, L. Truong *, n, R. Tanguay * & D. Reif n
MeSH headings : Animals; Gene Frequency; Genetic Variation; Genetics, Population; Genome / genetics; Polymorphism, Single Nucleotide / genetics; Zebrafish / genetics
TL;DR:
T5D is established as a model that is representative of diversity levels within laboratory zebrafish lines and demonstrated that experimental design and analysis can exert major effects when characterizing genetic diversity in heterogeneous populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
no blokes Is Essential for Male Viability and X Chromosome Gene Expression in the Australian Sheep Blowfly
Current Biology, 28(12), 1987–1992.e3.
MeSH headings : Animals; Diptera / genetics; Diptera / physiology; Dosage Compensation, Genetic / genetics; Female; Gene Expression; Genes, Insect / genetics; Genes, X-Linked / genetics; Male; X Chromosome / genetics
TL;DR:
This study supports the hypothesis on the origin of the Drosophila 4th chromosome and that a POF-like protein was required for normal gene expression on the ancient X chromosome and suggests that NBL could be important for X chromosome dosage compensation in L. cuprina.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Mitochondrial Genome Sequences and Structures Aid in the Resolution of Piroplasmida phylogeny
PLOS ONE, 11(11).
Contributors: M. Schreeg n, H. Marr n, J. Tarigo n, L. Cohn *, D. Bird n , n, M. Levy n, B. Wiegmann n , A. Birkenheuer n
MeSH headings : DNA, Protozoan / genetics; Genome, Mitochondrial; Humans; Phylogeny; Piroplasmida / classification; Piroplasmida / genetics; Protozoan Infections / parasitology
TL;DR:
Phylogenetic analysis of concatenated mitochondrial and 18S sequences as well as cox1 amino acid sequence identified five distinct Piroplasmida groups, each of which possesses a unique mitochondrial genome structure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Comparative Genomic Analysis Identifies Divergent Genomic Features of Pathogenic Enterococcus cecorum Including a Type IC CRISPR-Cas System, a Capsule Locus, an epa-Like Locus, and Putative Host Tissue Binding Proteins
PLOS ONE, 10(4).
MeSH headings : Animals; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; CRISPR-Cas Systems / genetics; Chickens; Comparative Genomic Hybridization; Enterococcus / classification; Enterococcus / genetics; Enterococcus / isolation & purification; Evolution, Molecular; Genetic Loci; Genome, Bacterial; Genomics; Genotype; Phylogeny; Poultry Diseases / epidemiology; Poultry Diseases / microbiology; Virulence / genetics
TL;DR:
Specific genomic regions, coding sequences, and predicted proteins which may be related to the divergent evolution and increased virulence of emerging pathogenic strains of EC are identified and potential mediators of virulence identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples
JOURNAL OF PROTEOME RESEARCH, 14(10), 4394–4401.
author keywords: N-linked glycosylation; INLIGHT; ovarian cancer; relative quantification; cancer biomarker; human plasma
MeSH headings : Biomarkers, Tumor / blood; Carbohydrate Sequence; Case-Control Studies; Chromatography, Liquid / methods; Female; Fucose / blood; Glycosylation; Humans; Hydrazines / chemistry; Molecular Sequence Data; Neoplasm Staging; Ovarian Neoplasms / blood; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / pathology; Polysaccharides / blood; Sialic Acids / blood; Staining and Labeling / methods; Tandem Mass Spectrometry / methods
TL;DR:
For all N-glycans, the vectors of the effects from stages II-IV were sequentially reversed, suggesting potential biological changes in OVC morphology or in host response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
A Novel Candidate Vaccine for Cytauxzoonosis Inferred from Comparative Apicomplexan Genomics
PLOS ONE, 8(8).
Contributors: J. Tarigo n, n, D. Bird n, C. Brown *, L. Cohn *, G. Dean n, M. Levy n, D. Doolan *
MeSH headings : Animals; Antigens, Protozoan / genetics; Antigens, Protozoan / immunology; Cat Diseases / immunology; Cat Diseases / parasitology; Cat Diseases / prevention & control; Cats; Cattle; Conserved Sequence; Genome, Protozoan; Genomics; Immune Sera / immunology; Piroplasmida / genetics; Piroplasmida / immunology; Protozoan Infections, Animal / immunology; Protozoan Infections, Animal / parasitology; Protozoan Infections, Animal / prevention & control; Protozoan Proteins / genetics; Protozoan Proteins / immunology; Protozoan Vaccines / genetics; Protozoan Vaccines / immunology; Recombinant Proteins / genetics; Recombinant Proteins / immunology; Synteny; Theileria parva / genetics; Theileria parva / immunology
TL;DR:
Comparative genomics is used to computationally and experimentally interpret the C. felis genome to identify a novel candidate vaccine antigen for cytauxzoonosis, and this approach emphasizes the use of comparative genomics as an accelerated path to developing vaccines against experimentally intractable pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 article
Computational and phylogenetic validation of nematode horizontal gene transfer
Scholl, E. H., & Bird, D. M. K. (2011, February 22). BMC BIOLOGY, Vol. 9.
Contributors: n & D. Bird n
MeSH headings : Animals; Cellulase / genetics; Evolution, Molecular; Gene Transfer, Horizontal; Genes, Helminth; Molecular Sequence Data; Nematoda / classification; Nematoda / genetics; Phylogeny
TL;DR:
A detailed phylogenetic analysis of cellulase genes in the free-living nematode Pristionchus pacificus at the species, genus and family levels substantiates the hypothesis that such transfer has been a driving force in the evolution of niche specificity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Sequence and genetic map of Meloidogyne hapla: A compact nematode genome for plant parasitism
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(39), 14802–14807.
Contributors: C. Opperman n, D. Bird n , V. Williamson *, D. Rokhsar *, M. Burke n, J. Cohn n, J. Cromer n, S. Diener n
author keywords: compaction; dauer; development; horizontal gene transfer; gene
MeSH headings : Animals; Base Sequence; Caenorhabditis elegans / genetics; Chromosome Mapping; Evolution, Molecular; Gene Duplication; Gene Transfer, Horizontal; Genome, Helminth; Host-Parasite Interactions / genetics; Molecular Sequence Data; Multigene Family; Operon; Phylogeny; Plants / parasitology; Synteny; Tylenchoidea / genetics
TL;DR:
Meloidogyne hapla is established as a tractable model plant-parasitic nematode amenable to forward and reverse genetics, and a complete genome sequence is presented that defines a platform to elucidate mechanisms of parasitism by what is the largest uncontrolled group of plant pathogens worldwide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Comprehensive Transcriptome Profiling in Tomato Reveals a Role for Glycosyltransferase in Mi-Mediated Nematode Resistance
Plant Physiology, 144(2), 1079–1092.
Contributors: J. Schaff n, D. Nielsen n , C. Smith n, n & D. Bird n
MeSH headings : Animals; Feeding Behavior / physiology; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Silencing; Genomics; Glycosyltransferases / metabolism; Host-Parasite Interactions / physiology; Solanum lycopersicum / enzymology; Solanum lycopersicum / genetics; Solanum lycopersicum / parasitology; Oligonucleotide Array Sequence Analysis; Plant Roots / enzymology; Plant Roots / metabolism; Plant Roots / parasitology; Reproduction / physiology; Tylenchoidea / physiology
TL;DR:
The root transcriptome of the resistant and susceptible cultivars ‘Motelle’ and ‘Moneymaker’ is interrogated, providing a picture of global gene expression changes in roots during compatible and incompatible associations with RKN, and point to candidates for further investigation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2005 journal article
Resolving tylenchid evolutionary relationships through multiple gene analysis derived from EST data
MOLECULAR PHYLOGENETICS AND EVOLUTION, 36(3), 536–545.
Contributors: n & D. Bird n
author keywords: Bayesian; Caenorhabditis elegans; COG; cyst nematode; orthologues; root-knot nematode
MeSH headings : Animals; Evolution, Molecular; Expressed Sequence Tags; Phylogeny; Selection, Genetic; Tylenchida / genetics
TL;DR:
This EST-based multi-gene analysis is a first step towards accomplishing genome-wide coverage for tylenchid evolutionary analyses and reveals significant differences in selective pressure for some genes under some hypotheses, though all but one gene are exclusively under purifying selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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