Works (1)
Updated: July 5th, 2023 15:33
2018 journal article
Using Antibodies and Mutants To Localize the Presumptive gH/gL Binding Site on Herpes Simplex Virus gD
JOURNAL OF VIROLOGY, 92(24).
author keywords: HSV; glycoproteins; neutralizing antibodies; cell-cell fusion; mar residues; escape mutants; herpes simplex virus
MeSH headings : Animals; Antibodies, Monoclonal / pharmacology; Antibodies, Neutralizing / pharmacology; Antibodies, Viral / pharmacology; Binding Sites / drug effects; Cell Line; Chlorocebus aethiops; Epitope Mapping; Mice; Models, Molecular; Protein Binding; Protein Conformation; Simplexvirus / physiology; Vero Cells; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / genetics; Viral Envelope Proteins / metabolism; Virus Internalization / drug effects
TL;DR:
Two residues on the presumed gH/gL interaction face of gD were identified that allowed for fusion and viral entry but were no longer sensitive to inhibition by MC2 or MC5, yet both were blocked by other MAbs.
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Added: December 10, 2018
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