Emily Mackey

Works (7)

Updated: July 9th, 2023 21:17

2022 journal article

Sex Differences in Mast Cell-Associated Disorders: A Life Span Perspective

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 14(10).

By: E. Mackey n & A. Moeser*

MeSH headings : Animals; Female; Humans; Longevity; Male; Mast Cells; Sex Characteristics
TL;DR: Sex differences in human mast cell-associated diseases and animal models are reviewed and the underlying biological mechanisms driving these sex differences are reviewed, which include adult gonadal sex hormones as well the emerging organizational role of perinatal gonadal hormones on mast cell activity and development. (via Semantic Scholar)
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Source: Web Of Science
Added: October 17, 2022

2020 journal article

Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(38), 23751–23761.

By: E. Mackey n, K. Thelen *, V. Bali*, M. Fardisi *, M. Trowbridge *, C. Jordan*, A. Moeser*

author keywords: mast cell; sex differences; immune; inflammation; histamine
MeSH headings : Anaphylaxis; Androgens / pharmacology; Animals; Disease Models, Animal; Female; Inflammation; Male; Mast Cells / drug effects; Mast Cells / physiology; Mice; Mice, Transgenic; Sex Factors; Testis / cytology; Testis / drug effects
TL;DR: It is shown that perinatal, but not adult gonadal, androgens play a protective role in MC-mediated anaphylaxis severity into adulthood, and proposed thatPerinatal androgens mediate their protective effects via programming of bone marrow MC precursors to exhibit reduced granule histamine and release. (via Semantic Scholar)
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Source: Web Of Science
Added: October 26, 2020

2019 journal article

Endocrine Disruption and Reproductive Pathology

TOXICOLOGIC PATHOLOGY, 47(8), 1049–1071.

By: S. Belcher n , J. Cline *, J. Conley *, S. Groeters*, W. Jefferson *, M. Law n, E. Mackey*, A. Suen * ...

Contributors: S. Belcher n , J. Cline *, J. Conley *, S. Groeters*, W. Jefferson *, M. Law n, E. Mackey*, A. Suen * ...

author keywords: endocrine disrupters; environmental toxicology; fish pathology; hormonal carcinogenesis; reproductive system; nonhuman primate; rodent pathology
MeSH headings : Animals; Congresses as Topic; Endocrine Disruptors / toxicity; Female; Fetal Development / drug effects; Heart / drug effects; Heart / embryology; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / metabolism; Prenatal Exposure Delayed Effects / pathology; Receptors, Androgen / genetics; Receptors, Androgen / metabolism; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Reproduction / drug effects; Species Specificity; Testis / drug effects; Testis / embryology; Testis / pathology; Uterus / drug effects; Uterus / embryology; Uterus / pathology
TL;DR: Investigations involving endocrine active substances and reproductive toxicity have dominated the landscape of ecotoxicological research, and it is now recognized that anthropomorphic substances may also adversely affect the nervous and immune systems via hormonal mechanisms and play substantial roles in metabolic diseases, such as type 2 diabetes and obesity. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 30, 2019

2019 journal article

Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(5), 1865-+.

By: S. D'Costa *, S. Ayyadurai, A. Gibson, E. Mackey n, M. Rajput, L. Sommerville *, N. Wilson, Y. Li* ...

author keywords: Mast cell; corticotropin-releasing factor receptor; stress; anaphylaxis; allergy; intestinal permeability
MeSH headings : Anaphylaxis / immunology; Animals; Cell Degranulation; Cell Line; Disease Models, Animal; Female; Histamine Release / genetics; Humans; Immunoglobulin E / metabolism; Intestinal Mucosa / metabolism; Mast Cells / physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Rats; Receptors, Corticotropin-Releasing Hormone / genetics; Receptors, Corticotropin-Releasing Hormone / metabolism; Stress, Psychological / immunology; Tight Junctions / metabolism
TL;DR: MC CRF2 is a negative global modulator of stimuli‐induced MC degranulation and limits the severity of IgE‐mediated anaphylaxis and stress‐related disease pathogenesis. (via Semantic Scholar)
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Source: Web Of Science
Added: April 20, 2020

2017 journal article

Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity

NEUROGASTROENTEROLOGY AND MOTILITY, 29(11).

By: C. Pohl*, J. Medland n, E. Mackey n, L. Edwards n , K. Bagley n, M. DeWilde*, K. Williams*, A. Moeser *

author keywords: developmental origins of health and disease; early life adversity; intestinal permeability; large animal model; mast cell; mast cell plexitis; translational research
MeSH headings : Animals; Cell Count; Colon / pathology; Diarrhea / etiology; Disease Models, Animal; Enteric Nervous System / pathology; Female; Ileum / metabolism; Ileum / pathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Intestines / pathology; Intestines / physiopathology; Male; Mast Cells / metabolism; Mast Cells / physiology; Stress, Psychological / complications; Sus scrofa; Tryptases / metabolism; Weaning
TL;DR: Early life adversity is a risk factor for development of gastrointestinal disorders later in life and the underlying mechanisms through which ELA and sex interact to influence disease susceptibility remains poorly understood. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology

JOURNAL OF LEUKOCYTE BIOLOGY, 102(6), 1299–1312.

By: S. Ayyadurai *, A. Gibson, S. D'Costa *, E. Overman*, L. Sommerville *, A. Poopal*, E. Mackey n, Y. Li *, A. Moeser *

author keywords: anaphylaxis; immune response; intestinal permeability; G protein-coupled receptor; allergy; functional bowel disorders
MeSH headings : Anaphylaxis / physiopathology; Animals; Bone Marrow Cells / cytology; Calcium / metabolism; Cell Degranulation; Cell Line; Cyclic AMP / metabolism; Extracellular Signal-Regulated MAP Kinases / metabolism; Gene Knockdown Techniques; Humans; Immunoglobulin E / metabolism; Intestinal Mucosa / metabolism; Male; Mast Cells / physiology; Mice, Inbred C57BL; Permeability; Rats; Receptors, Corticotropin-Releasing Hormone / agonists; Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors; Receptors, Corticotropin-Releasing Hormone / metabolism; Signal Transduction; Stress, Physiological; Urocortins / metabolism
TL;DR: A prominent role for CRF1 signaling in mast cells is revealed as a positive modulator of stimuli‐induced degranulation and in vivo pathophysiologic responses to immunologic and psychologic stress. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress

BIOLOGY OF SEX DIFFERENCES, 7.

By: E. Mackey*, S. Ayyadurai *, C. Pohl*, S. Costa*, Y. Li * & A. Moeser *

author keywords: Stress; Females; Sexual dimorphism; Mast cells; Intestine; Allergy
TL;DR: The role of biological sex on mast cells (MCs) is defined to provide a new understanding of sexual dimorphic responses in MCs and have direct implications for stress-related diseases associated with a female predominance and MC hyperactivity including irritable bowel syndrome, allergy, and anaphylaxis. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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