Works (11)
Updated: April 22nd, 2024 07:45
2023 article
Wound-triggered shape change microgels for the development of enhanced biomimetic function platelet-like particles
Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., … Brown, A. (2023, October 17). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 10.
author keywords: fibrin; hemostasis; synthetic platelet; trauma; wound healing
TL;DR:
Thrombin-sensitive PLPs are created that exhibit a wound-triggered shape change, induce significant clot retraction following exposure to thrombin and promote hemostasis and healing in vivo after trauma.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
Sources: Web Of Science, ORCID
Added: November 6, 2023
2021 journal article
Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation
BLOOD ADVANCES, 5(3), 613–627.
MeSH headings : Disseminated Intravascular Coagulation / drug therapy; Fibrin; Humans; Microcirculation; Nanogels; Thrombosis / drug therapy
TL;DR:
In vivo and in vivo, tPA-FSNs decreased the presentation of multiorgan microthrombi, recovered platelet counts, and improved bleeding outcomes in a DIC rodent model, demonstrating that a fibrinolytic agent loaded into fibrin-targeting nanogels could improve DIC outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: March 22, 2021
2021 article
Fibrin-specific poly(N-isopropylacrylamide) nanogels for targeted delivery of tissue-type plasminogen activator to treat thrombotic complications are well tolerated in vivo
Mihalko, E. P., Nellenbach, K., Krishnakumar, M., Moiseiwitsch, N., Sollinger, J., Cooley, B. C., & Brown, A. C. (2021, December 11). BIOENGINEERING & TRANSLATIONAL MEDICINE.
author keywords: disseminated intravascular coagulation; fibrin; nanogels; pNIPAM; targeted delivery; thrombosis; tissue plasminogen activator
TL;DR:
The therapeutic efficacy of targeted fibrin‐specific nanogel (FSN) design for targeted delivery of tPA to treat thrombotic complications is demonstrated and key translational parameters for tPA‐FSN therapeutics are evaluated, including optimal tPA •FSN dosage in a DIC rodent model and safety of intravenous tPA•FSN therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: December 20, 2021
2021 article
Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents
Krissanaprasit, A., Key, C. M., Froehlich, K., Pontula, S., Mihalko, E., Dupont, D. M., … LaBean, T. H. (2021, April 21). ADVANCED HEALTHCARE MATERIALS.
author keywords: anticoagulants; aptamers; direct thrombin inhibitors; nucleic acids; reversal agents; RNA nanotechnology; RNA origami
MeSH headings : Anticoagulants / pharmacology; Aptamers, Nucleotide / pharmacology; Blood Coagulation; RNA / pharmacology; Thrombin
TL;DR:
Compared to current commercial intravenous anticoagulants, RNA origami‐based molecules show promise as safer alternatives with rapid activity switching for future therapeutic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 10, 2021
2021 article
Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury
Todd, J., Bharadwaj, V. N., Nellenbach, K., Nandi, S., Mihalko, E., Copeland, C., … Stabenfeldt, S. E. (2021, June 11). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.
author keywords: blood-brain barrier; coagulopathy; neuroinflammation; permeability; platelet-like particles; traumatic brain injury
MeSH headings : Animals; Blood Platelets / metabolism; Blood-Brain Barrier / metabolism; Brain Injuries, Traumatic / complications; Brain Injuries, Traumatic / drug therapy; Brain Injuries, Traumatic / metabolism; Disease Models, Animal; Mice; Microglia / metabolism
TL;DR:
Results suggest that PLP-treatment addressed acute hypocoagulation and decreased BBB permeability followed by decreased neuroinflammation and fold-change tissue loss by 7 days post-injury, indicating that PLPs could be a potential therapeutic modality for TBI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 21, 2021
2021 journal article
Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses
ADVANCED THERAPEUTICS, 4(5).
author keywords: bleeding; Clotting; fibrin; hemostasis; microgel
TL;DR:
Soft microgels decorated with the peptide AHRPYAAK are found to significantly increase clot density in vitro and decrease bleeding in a rodent trauma model in vivo, indicating that FAMCYs are capable of recapitulating the platelet‐mimetic properties of previous designs while utilizing a less costly, more translational design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 5, 2021
2020 review
Clot Structure and Implications for Bleeding and Thrombosis
[Review of ]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 46(1), 96–104.
author keywords: fibrin; clot structure; atomic force microscopy; fibrinolysis; thrombosis
MeSH headings : Fibrin / metabolism; Fibrinolysis; Hemorrhage / metabolism; Hemorrhage / pathology; Humans; Thrombosis / metabolism; Thrombosis / pathology
TL;DR:
Known factors that contribute to changes in clot structure and the presence of structural clot changes in various disease states are examined to provide valuable information in forming therapeutic strategies for disease states where alterations in clotructure are observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 27, 2020
2020 journal article
Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(6), 2599–2609.
Contributors: E. Chee n, S. Nandi n, K. Nellenbach n, n, D. Snider n, L. Morrill n, A. Bond n, E. Sproul n
author keywords: antimicrobial; microgels; nanosilver; platelet-mimetic; wound healing
MeSH headings : Acrylic Resins / chemistry; Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Blood Platelets; Clot Retraction; Colony-Forming Units Assay; Fibrin / chemistry; Fibrin / immunology; Gels; Hemorrhage / drug therapy; Hemostasis / drug effects; Liver / injuries; Male; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Microgels; Silver / administration & dosage; Silver / chemistry; Wound Healing
TL;DR:
It is found that nanosilver incorporation does not affect base PLP performance while bestowing significant antimicrobial activity and enhancing infected wound healing outcomes, and Ag-PLPs have great promise for treating hemorrhage and improving healing following trauma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: March 16, 2020
2020 journal article
Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 577, 406–418.
author keywords: Fibrin; Biomimetic; Platelet; Hemophilia; Biomaterials
MeSH headings : Blood Coagulation; Blood Platelets; Fibrin; Plasma; Wound Healing
TL;DR:
PLPs improved clot network density, force generation, and stiffness, and promoted fibroblast migration within an in vitro model of early wound healing under hemophilic conditions, indicating that PLPs could provide a biomimetic platform for improving wound healing events in disease conditions that cause deficient fibrin network formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 24, 2020
2018 review
Material Strategies for Modulating Epithelial to Mesenchymal Transitions
[Review of ]. ACS BIOMATERIALS SCIENCE & ENGINEERING, 4(4), 1149–1161.
author keywords: epithelial to mesenchymal transition; EMT; mechanotransduction; fibrosis; development; transforming growth factor beta; EndoMT
TL;DR:
Drivers of the similar process of endothelial to mesenchymal transition (EndoMT) are discussed and corresponding material strategies for controlling EndoMT are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Targeted repair of heart injury by stem cells fused with platelet nanovesicles
NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.
TL;DR:
The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
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