Erin M. Kollitz
Works (5)
Updated: July 5th, 2023 15:47
2016 journal article
Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership
PLOS ONE, 11(12).
Contributors: n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n
Ed(s): C. Zhang n
MeSH headings : Animals; Biological Evolution; Hep G2 Cells; Humans; Lithocholic Acid / metabolism; Receptors, Calcitriol / metabolism; Vertebrates
open access via journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Molecular Cloning, Functional Characterization, and Evolutionary Analysis of Vitamin D Receptors Isolated from Basal Vertebrates
PLOS ONE, 10(4).
Contributors: n, G. Zhang n, M. Hawkins n, G. Whitfield*, D. Reif n & S. Kullman n
MeSH headings : Animals; Base Sequence; Cloning, Molecular; Computational Biology; Electrophoretic Mobility Shift Assay; Evolution, Molecular; Fishes / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Petromyzon / genetics; Phylogeny; Protein Binding; Protein Interaction Mapping; Receptors, Calcitriol / genetics; Sequence Analysis, DNA; Skates, Fish / genetics; Species Specificity; Two-Hybrid System Techniques
TL;DR:
This study compares molecular activities of vitamin D receptors (VDR) from basal species that diverged at key points in vertebrate evolution in order to infer derived and ancestral VDR functions of teleost paralogs and suggests that 1, 25D3 acts as a partial agonist in basal species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Functional diversification of vitamin D receptor paralogs in teleost fish after a whole genome duplication event
Endocrinology, 155(12), 4641–4654.
MeSH headings : Animals; Calcitriol / metabolism; Evolution, Molecular; Fish Proteins / genetics; Fish Proteins / metabolism; Gene Duplication; Genome; Nuclear Receptor Coactivators / metabolism; Oryzias; Receptors, Calcitriol / genetics; Receptors, Calcitriol / metabolism; Retinoid X Receptors / metabolism; Zebrafish
TL;DR:
The results imply that functional differences between VDRα and VDRβ occurred early in teleost evolution because they are conserved between distantly related species, and suggest that the observed differences may be associated with differential protein-protein interactions between the VDR paralogs and coactivators.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2011 journal article
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species
BMC BIOCHEMISTRY, 12.
MeSH headings : Animals; Bile Acids and Salts / metabolism; Evolution, Molecular; Humans; Ligands; Mice; Models, Molecular; Pregnane X Receptor; Protein Interaction Domains and Motifs; Rats; Receptors, Calcitriol / genetics; Receptors, Calcitriol / metabolism; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Species Specificity; Structure-Activity Relationship; Tetraodontiformes; Zebrafish
TL;DR:
These studies provide further evidence of the relationship between both FXR, PXR, and VDR ligand selectivity and cross-species variation in bile salt profiles and suggest a ligand-binding pocket architecture more similar to human and rat FXRs than to lamprey or zebrafish FXRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro
Aquatic Toxicology (Amsterdam, Netherlands), 98(3), 245–255.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Bile Acids and Salts / pharmacology; Binding Sites; Fresh Water; Genes, Reporter / genetics; Humans; Molecular Sequence Data; Oryzias / genetics; Protein Isoforms / genetics; Protein Isoforms / metabolism; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Titrimetry; Transcriptional Activation / drug effects; Transcriptional Activation / genetics; Transfection
TL;DR:
M mammalian two-hybrid studies demonstrated the ability of Fxralpha2, but not FxRALpha1, to interact with PGC-1alpha and SRC-1, and supported the results from the transient transfection reporter gene activation assays.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
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