Works (11)
Updated: August 11th, 2023 21:14
2022 article
Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration and tail-docking
Nixon, E., Chittenden, J. T., Baynes, R. E., & Messenger, K. M. (2022, July 14). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 7.
author keywords: NSAID; pain; pharmacodynamics; pharmacokinetics; piglet
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin / analogs & derivatives; Dinoprostone; Hydrocortisone; Ketoprofen / pharmacology; Ketoprofen / therapeutic use; Male; Orchiectomy / veterinary; Pain / veterinary; Swine; Tail
TL;DR:
Flunixin may be the best NSAID to use in mitigating castration and tail‐docking pain at the current label dose of ketoprofen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 16, 2022
2022 journal article
The pharmacokinetics of transdermal flunixin in lactating dairy goats
JOURNAL OF DAIRY SCIENCE, 105(1), 549–559.
author keywords: transdermal flunixin; goat; pharmacokinetics; drug residue; milk
MeSH headings : Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Clonixin / analogs & derivatives; Female; Goats; Lactation; Milk / chemistry
TL;DR:
Evaluated the pharmacokinetics of transdermal flunixin in dairy goats to determine a milk withdrawal interval (WDI) to avoid violative residue contamination in the food supply and propose safe residue levels in goat milk provides a milk WDI of 60 h using the US Food and Drug Administration tolerance limit method.
(via Semantic Scholar)
www.journalofdairyscience.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 17, 2021
2021 journal article
Antiviral Efficacy of Metal and Metal Oxide Nanoparticles against the Porcine Reproductive and Respiratory Syndrome Virus
Nanomaterials.
author keywords: porcine reproductive and respiratory syndrome virus; antiviral nanoparticle; viricidal efficacy; staphylococcus aureus
TL;DR:
Data support the further evaluation of these AVNP as candidate nanoparticles for incorporation into antimicrobial air-filtration systems to reduce transmission of PRRSV and other airborne pathogens.
(via Semantic Scholar)
Source: ORCID
Added: August 23, 2021
2021 journal article
Comparative effects of nonsteroidal anti-inflammatory drugs at castration and tail-docking in neonatal piglets
PLOS ONE, 16(11).
Ed(s): J. Loor
MeSH headings : Animal Husbandry / methods; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Castration / adverse effects; Castration / methods; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Dinoprostone / analysis; Extracellular Fluid / chemistry; Hydrocortisone / blood; Ketoprofen / therapeutic use; Male; Meloxicam / therapeutic use; Pain / drug therapy; Pain / etiology; Pain Management; Swine; Tail
TL;DR:
It is demonstrated that management strategies including administration of intramuscular flunixin or ketoprofen to reduce pain associated with processing will likely improve piglet health and welfare in the United States.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 1, 2021
2021 journal article
EVALUATION OF THE PHARMACOKINETIC BEHAVIOR OF TULATHROMYCIN (DRAXXIN) IN FLORIDA MANATEES (TRICHECHUS MANATUS LATIROSTRIS) UNDERGOING MEDICAL REHABILITATION
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(3), 880–885.
MeSH headings : Animals; Animals, Wild; Cattle; Disaccharides; Heterocyclic Compounds; Horses; Swine; Trichechus; Trichechus manatus
TL;DR:
The pharmacokinetic behavior of tulathromycin in Florida manatees can be used to optimize dosage regimens in this species, and this antibiotic has also been used in manatee with positive clinical outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 2, 2021
2021 journal article
Non-Steroidal Anti-Inflammatory Drugs: Pharmacokinetics and Mitigation of Procedural-Pain in Cattle
ANIMALS, 11(2).
author keywords: cattle; NSAID; flunixin; meloxicam; aspirin; pain control
TL;DR:
A comprehensively evaluated existing literature to summarize three NSAIDs (meloxicam, flunixin and aspirin) pharmacokinetics and administration outcome in regard to pain control during castration and disbudding procedures, in cattle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 27, 2021
2021 journal article
Producer and Veterinarian Perspectives towards Pain Management Practices in the US Cattle Industry
ANIMALS, 11(1).
author keywords: cattle; animal welfare; pain mitigation; analgesics; attitudes; survey; FARAD
TL;DR:
This study explored producer and veterinarian perspectives on pain management practices by exploring inquires received by Food Animal Residue Avoidance Databank (FARAD) regarding analgesic use in cattle and using a survey instrument to identify factors that impact pain management implementation in the US cattle industry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 21, 2021
2020 journal article
Comparative Plasma and Interstitial Fluid Pharmacokinetics of Meloxicam, Flunixin, and Ketoprofen in Neonatal Piglets
FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: piglet; pain; welfare; castration; NSAID; pharmacokinetics; interstitial fluid
TL;DR:
If drug concentrations in the ISF are more closely related to efficacy than the plasma, then the delay between the Tmax in plasma and ISF may be relevant to the timing of castration in order to provide the greatest analgesic effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020
2020 journal article
Plasma, urine and tissue concentrations of Flunixin and Meloxicam in Pigs
BMC VETERINARY RESEARCH, 16(1).
author keywords: Pig; Flunixin; Meloxicam; Pharmacokinetics; NSAIDs; Residue; Urine; Show
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Clonixin / urine; Half-Life; Injections, Intramuscular / veterinary; Kidney / chemistry; Liver / chemistry; Male; Meloxicam / blood; Meloxicam / pharmacokinetics; Meloxicam / urine; Sus scrofa
TL;DR:
The data suggest that pigs given a single intramuscular dose of meloxicam or flunixin are likely to have detectable levels of the parent drug in urine up to 2 days and 5 days, respectively, after the first dose, but unlikely to have tissue residues above the US FDA tolerance or EU MRL following negative urine testing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020
2020 journal article
Sterility and concentration of liposomal bupivacaine single-use vial when used in a multiple-dose manner
VETERINARY SURGERY, 49(4), 772–777.
MeSH headings : Anesthesia, Local / methods; Anesthesia, Local / veterinary; Anesthetics, Local / analysis; Anesthetics, Local / therapeutic use; Bupivacaine / analysis; Bupivacaine / therapeutic use; Drug Contamination; Drug Storage
TL;DR:
Single-use liposomal bupivacaine liposome injectable suspension used in a multiple-dose fashion for 5 days yielded no bacterial growth and remained sterile for 5 days when aseptic technique was used.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020
2017 journal article
Pharmacokinetics of C-14-ortho-phenylphenol following intravenous administration in pigs
JOURNAL OF APPLIED TOXICOLOGY, 37(4), 508–512.
author keywords: pharmacokinetics; ortho-phenylphenol; intravenous dose; pig; biocide
MeSH headings : Administration, Intravenous; Animals; Area Under Curve; Biphenyl Compounds / administration & dosage; Biphenyl Compounds / pharmacokinetics; Disinfectants / pharmacokinetics; Feces / chemistry; Half-Life; Male; Sus scrofa; Swine; Tissue Distribution
TL;DR:
Comparisons with other species suggest that 14C‐OPP clearance in pigs (2.48 ml h–1 kg–1) is less than that in humans and rats and that the kidneys play a crucial role in clearance with a large percentage of the dose being found in the urine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: ORCID, Web Of Science
Added: August 6, 2018
Education
Updated: August 15th, 2017 19:08
2017 - present
North Carolina State University Raleigh, NC, US
Comparative Biomedical Sciences Graduate Program
2013 - 2017
University of Surrey Guildford, Surrey, GB
BSc Veterinary Biosciences (Hons)
Funding History
Funding history based on the linked ORCID record. Updated: February 17th, 2020 12:14
grant
January 1, 2020 - January 1, 2022
Identifying practical pharmaceutical approaches to mitigate castration pain on commercial swine farms
American Veterinary Medical Foundation
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