Erin P. Sproul

Works (5)

Updated: July 5th, 2023 15:35

2019 journal article

Development of Biomimetic Antimicrobial Platelet-Like Particles Comprised of Microgel Nanogold Composites

Regenerative Engineering and Translational Medicine, 6(3), 299–309.

By: E. Sproul n, S. Nandi n, E. Chee n, S. Sivadanam n, B. Igo  n, L. Schreck*, A. Brown n 

author keywords: Synthetic platelet; Fibrin; Hemostatic material; Trauma; Antimicrobial material; Microgels
TL;DR: These results demonstrate NGCs fabricated through noncovalent and covalent methods retain deformability necessary for clot collapse and exhibit some antimicrobial potential, and are promising materials for preventing blood loss and infection following traumatic injury. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: October 12, 2020

2019 journal article

Fibrin Nanoparticles Coupled with Keratinocyte Growth Factor Enhance the Dermal Wound-Healing Rate

ACS Applied Materials & Interfaces, 11(4), 3771–3780.

By: I. Muhamed n, E. Sproul n, F. Ligler n & A. Brown n 

author keywords: fibrin nanoparticles; tissue regeneration; cell migration; microfluidics; wound healing; biomaterials; cell migration; in vitro 3D wound model and in vivo dermal wound model
MeSH headings : Animals; Biocompatible Materials / chemistry; Cell Movement / drug effects; Fibrin / chemistry; Fibroblast Growth Factor 7 / chemistry; Fibroblast Growth Factor 7 / therapeutic use; Mice; Microfluidics; Nanoparticles / chemistry; Wound Healing / drug effects
TL;DR: FBNs described here are constructed from physiologically relevant fibrin concentrations that support new tissue and dermal wound scaffold formation when coupled with growth factors and can be potentially administered with other tissue-healing factors and inflammatory mediators to improve wound- healing outcomes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 18, 2019

2018 journal article

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

Biomaterials Science, 7(2), 669–682.

By: S. Nandi n, E. Sproul n, K. Nellenbach n, M. Erb n, L. Gaffney n, D. Freytes n, A. Brown n 

MeSH headings : Animals; Biomimetic Materials / chemistry; Blood Platelets / metabolism; Blood Platelets / physiology; Fibrin / chemistry; Fibrin / pharmacology; Humans; Mechanical Phenomena; Mice; Platelet Activation / drug effects; Skin / drug effects; Skin / injuries; Wound Healing / drug effects
TL;DR: The utility of PLPs for enhancing wound repair is demonstrated and the role of native platelet-mediated clot retraction in wound healing is provided, to provide insight into the role in vitro and in vivo models of wound healing. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: February 18, 2019

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

Nature Biomedical Engineering, 2(1), 17–26.

By: J. Tang  n, T. Su n, K. Huang n , P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

Contributors: J. Tang  n, T. Su n, K. Huang n , P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

TL;DR: The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 article

Fibrin biomaterials for tissue regeneration and repair

PEPTIDES AND PROTEINS AS BIOMATERIALS FOR TISSUE REGENERATION AND REPAIR, pp. 151–173.

By: E. Sproul n, S. Nandi n & A. Brown n 

TL;DR: This chapter first provides an overview of the structure and function of fibrin(ogen) and details the role offibrin-cell interactions in wound repair and the design and use of fibin-based materials for promoting tissue repair. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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