Eric Brooks
Also known as: E. R. Brooks; E. Brooks
Works (8)
Updated: April 3rd, 2024 17:07
2020 article
Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure
Brooks, E. R., Islam, M. T., Anderson, K. V., & Zallen, J. A. (2020, October 13). (Vol. 10). Vol. 10.
TL;DR:
Results reveal a morphogenetic program of patterned apical constriction governed by Shh signaling that generates structural changes in the developing mammalian brain.
(via Semantic Scholar)
doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 23, 2022
2020 journal article
Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure
ELife, 9.
MeSH headings : Animals; Brain / embryology; Cell Shape; Hedgehog Proteins / metabolism; Hedgehog Proteins / physiology; Mice; Mice, Inbred C57BL; Neural Crest / embryology; Neural Tube / embryology; Neural Tube / growth & development
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 23, 2022
2015 journal article
In vivo investigation of cilia structure and function using Xenopus.
Methods in Cell Biology.
MeSH headings : Animals; Axoneme / physiology; Basal Bodies / physiology; Cilia / physiology; Embryo, Nonmammalian / cytology; Fluorescent Antibody Technique / methods; Image Processing, Computer-Assisted; Microscopy, Confocal; Morpholinos / genetics; Oligonucleotides, Antisense / genetics; Staining and Labeling / methods; Tissue Fixation / methods; Xenopus laevis
TL;DR:
Embryological and cell biological methods for the investigation of cilia structure and function in Xenopus laevis are presented, with a focus on quantitative live and fixed imaging.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2014 journal article
Coordinated genomic control of ciliogenesis and cell movement by RFX2.
ELife.
MeSH headings : Animals; Cell Movement / genetics; Cilia / metabolism; Computational Biology; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Databases, Genetic; Embryo, Nonmammalian / metabolism; Epithelial Cells / metabolism; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Humans; Morphogenesis; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors / genetics; Transcription Factors / metabolism; Xenopus Proteins / genetics; Xenopus Proteins / metabolism; Xenopus laevis / embryology
TL;DR:
Rfx2 coordinates multiple, distinct gene expression programs in MCCs, regulating genes that control cell movement, ciliogenesis, and cilia function, and serves as a paradigm for understanding genomic control of cell biological processes that span from early cell morphogenetic events to terminally differentiated cellular functions.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2014 journal article
Multiciliated cells.
Current Biology : CB.
MeSH headings : Biological Evolution; Cell Polarity; Cilia / metabolism; Eukaryota / cytology; Eukaryota / physiology; Humans; Microtubules / metabolism; Phylogeny
TL;DR:
The general phylogeny and physiology of multiciliation is reviewed and the current understanding of the developmental and cellular events underlying the specification, differentiation and function of multiciliated cells in vertebrates is detailed.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2013 journal article
The Small GTPase Rsg1 is important for the cytoplasmic localization and axonemal dynamics of intraflagellar transport proteins.
Cilia.
TL;DR:
The data suggest that Rsg1 is a regulator of multiple aspects of ciliogenesis, including apical trafficking of basal bodies and the localization and dynamics intraflagellar transport proteins.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2012 journal article
Control of vertebrate intraflagellar transport by the planar cell polarity effector Fuz.
The Journal of Cell Biology.
MeSH headings : Animals; Cell Polarity / physiology; Cilia / physiology; Flagella / physiology; Humans; Protein Transport; Xenopus; Xenopus Proteins / genetics; Xenopus Proteins / physiology
TL;DR:
The planar cell polarity effector Fuz is required for normal particle dynamics of the intraflagellar transport system, specifically in the retrograde transport of proteins.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2007 journal article
Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar.
International Journal of Cancer.
author keywords: cytochrome P450; polycyclic aromatic hydrocarbons; coal tar; DNA adducts; chemical inhibition
MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / drug effects; Benzo(a)pyrene / antagonists & inhibitors; Benzo(a)pyrene / toxicity; Benzopyrenes / toxicity; Carcinogens / antagonists & inhibitors; Carcinogens / toxicity; Coal Tar / chemistry; Complex Mixtures / isolation & purification; Complex Mixtures / pharmacology; Complex Mixtures / standards; Cytochrome P-450 CYP1A1 / antagonists & inhibitors; Cytochrome P-450 CYP1A1 / drug effects; Cytochrome P-450 CYP1B1; DNA / drug effects; DNA / metabolism; DNA Adducts / analysis; Humans; Polycyclic Aromatic Hydrocarbons / isolation & purification; Polycyclic Aromatic Hydrocarbons / pharmacology; Polycyclic Aromatic Hydrocarbons / standards; Tumor Cells, Cultured
TL;DR:
The decreases in PAH‐DNA adduct formation on co‐treatment with SRM 1597 revealed inhibitory effects on the CYP enzymes that convert carcinogenic PAH into DNA‐binding metabolites.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
Employment
Updated: March 23rd, 2022 15:02
2022 - present
North Carolina State University Raleigh, North Carolina, US
Assistant Professor
Molecular Biosciences
2014 - 2021
Sloan-Kettering Institute New York, NY, US
Postdoctoral Fellow
Developmental Biology
Education
Updated: October 14th, 2020 13:43
2007 - 2014
University of Texas at Austin TX, TX, US
PhD
Cell and Molecular Biology
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