Eric Brooks

Also known as: E. R. Brooks; E. Brooks

Works (12)

Updated: December 22nd, 2024 14:00

2024 article

A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate

Brooks, E. R., Moorman, A. R., Bhattacharya, B., Prudhomme, I. S., Land, M., Alcorn, H. L., … Zallen, J. A. (2024, August 26).

By: E. Brooks n , A. Moorman*, B. Bhattacharya *, I. Prudhomme*, M. Land *, H. Alcorn*, R. Sharma *, D. Pe'er *, J. Zallen *

Source: ORCID
Added: September 1, 2024

2024 article

A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate

Brooks, E. R., Moorman, A. R., Bhattacharya, B., Prudhomme, I., Land, M., Alcorn, H. L., … Zallen, J. A. (2024, November 14).

By: E. Brooks n , A. Moorman*, B. Bhattacharya *, I. Prudhomme*, M. Land *, H. Alcorn*, R. Sharma *, D. Pe’er *, J. Zallen *

Source: ORCID
Added: November 14, 2024

2024 article

A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate

Brooks, E. R., Moorman, A. R., Bhattacharya, B., Prudhomme, I., Land, M., Alcorn, H. L., … Zallen, J. A. (2024, November 14).

By: E. Brooks n , A. Moorman*, B. Bhattacharya *, I. Prudhomme*, M. Land *, H. Alcorn*, R. Sharma *, D. Pe’er *, J. Zallen *

Source: ORCID
Added: November 14, 2024

2024 article

Wnt pathway modulation is required to correctly execute multiple independent cellular dynamic programs during cranial neural tube closure

Bogart, A. H., & Brooks, E. R. (2024, December 20).

By: A. Bogart n & E. Brooks n 

Source: ORCID
Added: December 21, 2024

2020 article

Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

Brooks, E. R., Islam, M. T., Anderson, K. V., & Zallen, J. A. (2020, October 13). (Vol. 10). Vol. 10.

By: E. Brooks* , M. Islam*, K. Anderson * & J. Zallen *

TL;DR: Results reveal a morphogenetic program of patterned apical constriction governed by Shh signaling that generates structural changes in the developing mammalian brain. (via Semantic Scholar)
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Source: ORCID
Added: March 23, 2022

2020 journal article

Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

ELife, 9.

By: E. Brooks* , M. Islam*, K. Anderson * & J. Zallen *

MeSH headings : Animals; Brain / embryology; Cell Shape; Hedgehog Proteins / metabolism; Hedgehog Proteins / physiology; Mice; Mice, Inbred C57BL; Neural Crest / embryology; Neural Tube / embryology; Neural Tube / growth & development
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: March 23, 2022

2015 journal article

In vivo investigation of cilia structure and function using Xenopus.

Methods in Cell Biology.

Eric Brooks

MeSH headings : Animals; Axoneme / physiology; Basal Bodies / physiology; Cilia / physiology; Embryo, Nonmammalian / cytology; Fluorescent Antibody Technique / methods; Image Processing, Computer-Assisted; Microscopy, Confocal; Morpholinos / genetics; Oligonucleotides, Antisense / genetics; Staining and Labeling / methods; Tissue Fixation / methods; Xenopus laevis
TL;DR: Embryological and cell biological methods for the investigation of cilia structure and function in Xenopus laevis are presented, with a focus on quantitative live and fixed imaging. (via Semantic Scholar)
Source: ORCID
Added: March 23, 2022

2014 journal article

Coordinated genomic control of ciliogenesis and cell movement by RFX2.

ELife.

Eric Brooks

MeSH headings : Animals; Cell Movement / genetics; Cilia / metabolism; Computational Biology; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Databases, Genetic; Embryo, Nonmammalian / metabolism; Epithelial Cells / metabolism; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Humans; Morphogenesis; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors / genetics; Transcription Factors / metabolism; Xenopus Proteins / genetics; Xenopus Proteins / metabolism; Xenopus laevis / embryology
TL;DR: Rfx2 coordinates multiple, distinct gene expression programs in MCCs, regulating genes that control cell movement, ciliogenesis, and cilia function, and serves as a paradigm for understanding genomic control of cell biological processes that span from early cell morphogenetic events to terminally differentiated cellular functions. (via Semantic Scholar)
Source: ORCID
Added: March 23, 2022

2014 journal article

Multiciliated cells.

Current Biology : CB.

Eric Brooks

MeSH headings : Biological Evolution; Cell Polarity; Cilia / metabolism; Eukaryota / cytology; Eukaryota / physiology; Humans; Microtubules / metabolism; Phylogeny
TL;DR: The general phylogeny and physiology of multiciliation is reviewed and the current understanding of the developmental and cellular events underlying the specification, differentiation and function of multiciliated cells in vertebrates is detailed. (via Semantic Scholar)
Source: ORCID
Added: March 23, 2022

2013 journal article

The Small GTPase Rsg1 is important for the cytoplasmic localization and axonemal dynamics of intraflagellar transport proteins.

Cilia.

Eric Brooks

TL;DR: The data suggest that Rsg1 is a regulator of multiple aspects of ciliogenesis, including apical trafficking of basal bodies and the localization and dynamics intraflagellar transport proteins. (via Semantic Scholar)
Source: ORCID
Added: March 23, 2022

2012 journal article

Control of vertebrate intraflagellar transport by the planar cell polarity effector Fuz.

The Journal of Cell Biology.

Eric Brooks

MeSH headings : Animals; Cell Polarity / physiology; Cilia / physiology; Flagella / physiology; Humans; Protein Transport; Xenopus; Xenopus Proteins / genetics; Xenopus Proteins / physiology
TL;DR: The planar cell polarity effector Fuz is required for normal particle dynamics of the intraflagellar transport system, specifically in the retrograde transport of proteins. (via Semantic Scholar)
Source: ORCID
Added: March 23, 2022

2006 journal article

Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar.

International Journal of Cancer.

Eric Brooks

author keywords: cytochrome P450; polycyclic aromatic hydrocarbons; coal tar; DNA adducts; chemical inhibition
MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / drug effects; Benzo(a)pyrene / antagonists & inhibitors; Benzo(a)pyrene / toxicity; Benzopyrenes / toxicity; Carcinogens / antagonists & inhibitors; Carcinogens / toxicity; Coal Tar / chemistry; Complex Mixtures / isolation & purification; Complex Mixtures / pharmacology; Complex Mixtures / standards; Cytochrome P-450 CYP1A1 / antagonists & inhibitors; Cytochrome P-450 CYP1A1 / drug effects; Cytochrome P-450 CYP1B1; DNA / drug effects; DNA / metabolism; DNA Adducts / analysis; Humans; Polycyclic Aromatic Hydrocarbons / isolation & purification; Polycyclic Aromatic Hydrocarbons / pharmacology; Polycyclic Aromatic Hydrocarbons / standards; Tumor Cells, Cultured
TL;DR: The decreases in PAH‐DNA adduct formation on co‐treatment with SRM 1597 revealed inhibitory effects on the CYP enzymes that convert carcinogenic PAH into DNA‐binding metabolites. (via Semantic Scholar)
Source: ORCID
Added: March 23, 2022

Employment

Updated: March 23rd, 2022 15:02

2022 - present

North Carolina State University Raleigh, North Carolina, US
Assistant Professor Molecular Biosciences

2014 - 2021

Sloan-Kettering Institute New York, NY, US
Postdoctoral Fellow Developmental Biology

Education

Updated: October 14th, 2020 13:43

2007 - 2014

University of Texas at Austin TX, TX, US
PhD Cell and Molecular Biology

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