Erik S Pena

College of Engineering

Works (5)

Updated: April 30th, 2024 05:02

2024 journal article

Comparative study of acetalated-dextran microparticle fabrication methods for a clinically translatable subunit-based influenza vaccine

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 652.

By: E. Pena n, C. Batty *, D. Hendy *, S. Yang *, L. Ontiveros-Padilla *, R. Stiepel *, J. Ting *, K. Ainslie  n, E. Bachelder *

author keywords: Polymeric particles; Emulsion; Electrospray; Spray dry; Drug delivery system
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: April 29, 2024

2023 article

Immunogenicity of an adjuvanted broadly active influenza vaccine in immunocompromised and diverse populations

Hendy, D. A., Pena, E. S., Ontiveros-Padilla, L., Dixon, T. A., Middleton, D. D., Williamson, G. L., … Ainslie, K. M. (2023, December 8). BIOENGINEERING & TRANSLATIONAL MEDICINE.

By: D. Hendy *, E. Pena n, L. Ontiveros-Padilla *, T. Dixon*, D. Middleton *, G. Williamson*, N. Lukesh*, S. Simpson* ...

author keywords: aging; chemotherapy; collaborative cross; obesity; polymeric microparticles
TL;DR: This vaccine platform consisting of acetalated dextran microparticles loaded with COBRA HA and the STING agonist cyclic GMP‐AMP had variable efficacy in these populations supporting work to better tailor adjuvants to specific populations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: December 18, 2023

2023 article

Metal-organic coordination polymers for delivery of immunomodulatory agents, and infectious disease and cancer vaccines

Pena, E. S., Lifshits, L. M., Eckshtain-Levi, M., Bachelder, E. M., & Ainslie, K. M. (2023, January 11). WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY.

By: E. Pena n, L. Lifshits *, M. Eckshtain-Levi*, E. Bachelder * & K. Ainslie  n

author keywords: adjuvant; antigen; biocompatibility; cancer; CpG; drug delivery platform; MOFs; OVA; vaccine; ZIF-8
MeSH headings : Humans; Polymers / chemistry; Cancer Vaccines; Immunomodulating Agents; Metal-Organic Frameworks / chemistry; Metals; Communicable Diseases; Neoplasms / drug therapy
TL;DR: This review highlighted some of the recent efforts directed toward developing CP-based drug delivery platforms with the emphasis on vaccines against cancer, infectious diseases, and viruses, and briefly described most relevant characterization techniques. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: January 30, 2023

2022 journal article

Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine br

ACS BIOMATERIALS SCIENCE & ENGINEERING, 8(4), 1573–1582.

By: D. Varma*, C. Batty *, R. Stiepel *, E. Graham-Gurysh *, J. Roque *, E. Pena n, M. Zahid *, K. Qiu* ...

author keywords: intranasal; influenza; hemagglutinin; vaccine; subunit; mucosal
MeSH headings : Animals; Antibodies, Viral; Female; Hemagglutinin Glycoproteins, Influenza Virus / genetics; Humans; Immunoglobulin A; Immunoglobulin G; Influenza A Virus, H1N1 Subtype / genetics; Influenza Vaccines; Influenza, Human / prevention & control; Mice; Orthomyxoviridae Infections / prevention & control
TL;DR: Overall, this study indicates the utility of an intranasal gel for the delivery of COBRAs for the generation of serum and mucosal humoral responses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 16, 2022

2022 journal article

STING agonist-containing microparticles improve seasonal influenza vaccine efficacy and durability in ferrets over standard adjuvant

JOURNAL OF CONTROLLED RELEASE, 347, 356–368.

By: M. Gallovic*, R. Junkins*, A. Sandor*, E. Pena*, C. Sample *, A. Mason*, L. Arwood*, R. Sahm* ...

author keywords: Vaccine; Acetetlated dextran; Influenza; Viral immunology; STING
MeSH headings : Adjuvants, Immunologic; Animals; Antibodies, Viral; Ferrets; Humans; Influenza Vaccines; Influenza, Human; Orthomyxoviridae Infections / prevention & control; Seasons; Vaccine Efficacy
TL;DR: A monoaxial formulation of polymeric acetalated dextran microparticles (MPs) is evaluated to deliver the STING agonist cyclic GMP-AMP (cGAMP) which achieved >10× dose-sparing effects compared to other published work. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 20, 2022

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