Erik S. Welf

Works (5)

Updated: August 17th, 2023 21:16

2015 journal article

Linking morphodynamics and directional persistence of T lymphocyte migration

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 12(106).

By: X. Liu n, E. Welf n & J. Haugh n 

author keywords: cell migration; chemokine; TIRF microscopy; image analysis
MeSH headings : Actins / physiology; Animals; Cell Movement / physiology; Cell Polarity / physiology; Cell Size; Cells, Cultured; Computer Simulation; Humans; Membrane Fluidity / physiology; Mice; Models, Biological; Models, Statistical; Molecular Motor Proteins / physiology; Stochastic Processes; T-Lymphocytes / cytology; T-Lymphocytes / physiology
TL;DR: This study uses total internal reflection fluorescence microscopy to monitor T lymphocytes' areas of contact with a surface presenting adhesive ICAM-1 and the chemokine, and suggests that switching of the dominant protrusion between the two sides of the migration axis is associated with persistent migration, whereas the opposite is true of cell turning. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility

MOLECULAR BIOLOGY OF THE CELL, 24(24), 3945–3955.

By: E. Welf n, H. Johnson n & J. Haugh n 

MeSH headings : Actin Cytoskeleton; Actins / metabolism; Actomyosin / physiology; Animals; Cell Adhesion / physiology; Cell Adhesion Molecules / genetics; Cell Movement / physiology; Computer Simulation; Extracellular Matrix / metabolism; Focal Adhesions / physiology; Integrins / genetics; Integrins / metabolism; Integrins / physiology; Mechanotransduction, Cellular; Myosin Type II / metabolism; Pseudopodia / metabolism; Signal Transduction / genetics; rhoA GTP-Binding Protein / metabolism
TL;DR: A physicochemical model is used to describe the coupling of adhesion, cytoskeletal, and signaling dynamics during cell migration, and analysis of stochastic simulations predicts relationships between measurable quantities that reflect partitioning of stress between F-actin–bound adhesions. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

JOURNAL OF CELL BIOLOGY, 197(1), 105–114.

By: E. Welf n, S. Ahmed n, H. Johnson n, A. Melvin n & J. Haugh n 

MeSH headings : Animals; Cell Movement; Cells, Cultured; Fibroblasts / cytology; Fibroblasts / enzymology; Fibroblasts / metabolism; Mice; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction / drug effects
TL;DR: Migrating fibroblasts reorient directionality by PI3K-dependent branching and pivoting of protrusions, a mechanism that allows fibro Blasts to align with an external chemotactic gradient. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 conference paper

Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics

Methods in cell biology, vol 110: computational methods in cell biology, 110, 223–241.

By: E. Welf & J. Haugh 

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Signaling pathways that control cell migration: models and analysis

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 3(2), 231–240.

By: E. Welf n & J. Haugh n 

MeSH headings : Cell Movement / physiology; Humans; Models, Biological; Signal Transduction / physiology; Systems Biology
TL;DR: Some of the more recent applications of quantitative modeling and analysis in the field of cell migration are highlighted and it is clear that the challenge ahead will be to characterize the couplings between them in an integrated framework. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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