Works (5)
Updated: August 17th, 2023 21:16
2015 journal article
Linking morphodynamics and directional persistence of T lymphocyte migration
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 12(106).
author keywords: cell migration; chemokine; TIRF microscopy; image analysis
MeSH headings : Actins / physiology; Animals; Cell Movement / physiology; Cell Polarity / physiology; Cell Size; Cells, Cultured; Computer Simulation; Humans; Membrane Fluidity / physiology; Mice; Models, Biological; Models, Statistical; Molecular Motor Proteins / physiology; Stochastic Processes; T-Lymphocytes / cytology; T-Lymphocytes / physiology
TL;DR:
This study uses total internal reflection fluorescence microscopy to monitor T lymphocytes' areas of contact with a surface presenting adhesive ICAM-1 and the chemokine, and suggests that switching of the dominant protrusion between the two sides of the migration axis is associated with persistent migration, whereas the opposite is true of cell turning.
(via Semantic Scholar)
open access via royalsocietypublishing.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility
MOLECULAR BIOLOGY OF THE CELL, 24(24), 3945–3955.
MeSH headings : Actin Cytoskeleton; Actins / metabolism; Actomyosin / physiology; Animals; Cell Adhesion / physiology; Cell Adhesion Molecules / genetics; Cell Movement / physiology; Computer Simulation; Extracellular Matrix / metabolism; Focal Adhesions / physiology; Integrins / genetics; Integrins / metabolism; Integrins / physiology; Mechanotransduction, Cellular; Myosin Type II / metabolism; Pseudopodia / metabolism; Signal Transduction / genetics; rhoA GTP-Binding Protein / metabolism
TL;DR:
A physicochemical model is used to describe the coupling of adhesion, cytoskeletal, and signaling dynamics during cell migration, and analysis of stochastic simulations predicts relationships between measurable quantities that reflect partitioning of stress between F-actin–bound adhesions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism
JOURNAL OF CELL BIOLOGY, 197(1), 105–114.
MeSH headings : Animals; Cell Movement; Cells, Cultured; Fibroblasts / cytology; Fibroblasts / enzymology; Fibroblasts / metabolism; Mice; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction / drug effects
TL;DR:
Migrating fibroblasts reorient directionality by PI3K-dependent branching and pivoting of protrusions, a mechanism that allows fibro Blasts to align with an external chemotactic gradient.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 conference paper
Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics
Methods in cell biology, vol 110: computational methods in cell biology, 110, 223–241.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Signaling pathways that control cell migration: models and analysis
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 3(2), 231–240.
MeSH headings : Cell Movement / physiology; Humans; Models, Biological; Signal Transduction / physiology; Systems Biology
TL;DR:
Some of the more recent applications of quantitative modeling and analysis in the field of cell migration are highlighted and it is clear that the challenge ahead will be to characterize the couplings between them in an integrated framework.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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