Works (121)

Updated: January 31st, 2024 05:01

2023 article

A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo

Tsai, H.-H. D., House, J. S., Wright, F. A., Chiu, W. A., & Rusyn, I. (2023, April 20). TOXICOLOGICAL SCIENCES.

By: H. Tsai*, J. House*, F. Wright n, W. Chiu* & I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: transcriptomic; petroleum; grouping; dose-response; HTTr; NAMs
MeSH headings : Humans; Transcriptome; Petroleum / toxicity; Endothelial Cells; Gene Expression Profiling; Cell Line
Sources: Web Of Science, ORCID
Added: May 22, 2023

2023 journal article

Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity

TOXICOLOGICAL SCIENCES.

By: C. Sakolish*, H. Moyer*, H. Tsai*, L. Ford*, A. Dickey n, F. Wright n, G. Han*, P. Bajaj* ...

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: kidney; in vitro models; validation
Source: Web Of Science
Added: September 5, 2023

2023 article

Application of Ion Mobility Spectrometry-Mass Spectrometry for Compositional Characterization and Fingerprinting of a Library of Diverse Crude Oil Samples

Cordova, A. C., Dodds, J. N., Tsai, H.-H. D., Lloyd, D. T., Roman-Hubers, A. T., Wright, F. A., … Rusyn, I. (2023, August 22). ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY.

By: A. Cordova*, J. Dodds*, H. Tsai*, D. Lloyd n, A. Roman-Hubers*, F. Wright n, W. Chiu*, T. McDonald* ...

co-author countries: United States of America 🇺🇸
author keywords: Analytical chemistry; Environmental chemistry; Hazard; risk assessment; Mixtures; Oil spills
Source: Web Of Science
Added: September 5, 2023

2023 journal article

Genetic Modifiers of Cystic Fibrosis Lung Disease Severity

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207(10), 1324–1333.

By: Y. Zhou*, P. Gallins*, R. Pace*, H. Dang*, M. Aksit, E. Blue*, K. Buckingham*, J. Collaco ...

co-author countries: Canada 🇨🇦 Germany 🇩🇪 France 🇫🇷 Japan 🇯🇵 United States of America 🇺🇸
author keywords: cystic fibrosis; whole-genome sequencing; lung disease severity; GWAS/TWAS; pathway analyses
MeSH headings : Humans; Cystic Fibrosis / genetics; Genome-Wide Association Study / methods; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Patient Acuity; Lung; Microtubule-Associated Proteins / genetics
Sources: Web Of Science, ORCID
Added: May 16, 2023

2023 journal article

Integrative Chemical-Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams

TOXICS, 11(7).

By: A. Cordova*, W. Klaren*, L. Ford*, F. Grimm*, E. Baker*, Y. Zhou n, F. Wright n, I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: UVCB; petroleum; regulatory risk assessment; read-across; ion mobility spectrometry
Sources: Web Of Science, ORCID
Added: July 6, 2023

2023 article

Simultaneous modeling of multivariate heterogeneous responses and heteroskedasticity via a two-stage composite likelihood

Ting, B. W. W., Wright, F. A., & Zhou, Y.-H. (2023, May 22). BIOMETRICAL JOURNAL.

By: B. Ting n, F. Wright n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: heterogeneity; heteroskedasticity; multivariate statistics; precision medicine; prediction
Sources: Web Of Science, ORCID
Added: May 23, 2023

2023 article

Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations

Rusyn, I., & Wright, F. A. (2023, December 23). TOXICOLOGICAL SCIENCES.

By: I. Rusyn* & F. Wright n

co-author countries: United States of America 🇺🇸
author keywords: cancer risk assessment; risk assessment; safety evaluation
Source: Web Of Science
Added: January 29, 2024

2022 journal article

A Population-Based Human In Vitro Approach to Quantify Inter-Individual Variability in Responses to Chemical Mixtures

TOXICS, 10(8).

By: L. Ford*, S. Jang*, Z. Chen*, Y. Zhou n, P. Gallins n, F. Wright n, W. Chiu*, I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: population-wide; inter-individual variability; toxicodynamics; chemical mixtures; defined mixtures; human health risk assessment; uncertainty factors; genome-wide association study
Sources: Web Of Science, ORCID
Added: August 2, 2022

2022 journal article

A resource for integrated genomic analysis of the human liver

SCIENTIFIC REPORTS, 12(1).

co-author countries: United States of America 🇺🇸
MeSH headings : Bayes Theorem; Genome-Wide Association Study / methods; Genomics; Humans; Liver; Polymorphism, Single Nucleotide; Quantitative Trait Loci
Sources: Web Of Science, ORCID
Added: September 8, 2022

2022 journal article

Characterization of compositional variability in petroleum substances

FUEL, 317.

By: A. Roman-Hubers*, A. Cordova*, A. Rohde*, W. Chiu*, T. McDonald*, F. Wright*, J. Dodds n, E. Baker n, I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: UVCB; Registration; Variability; IMS-MS
Sources: Web Of Science, ORCID
Added: May 10, 2022

2022 journal article

Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 132.

By: G. Boysen*, I. Rusyn*, W. Chiu* & F. Wright n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Biomarkers; Butadienes / chemistry; Butadienes / metabolism; Butadienes / toxicity; Carcinogens / metabolism; Carcinogens / toxicity; Hemoglobins / metabolism; Humans; Mice
Source: Web Of Science
Added: June 6, 2022

2022 journal article

Correlation Analysis of Variables From the Atherosclerosis Risk in Communities Study

FRONTIERS IN PHARMACOLOGY, 13.

By: M. Mandal*, J. Levy, C. Ives*, S. Hwang*, Y. Zhou n, A. Motsinger-Reif*, H. Pan*, W. Huggins* ...

co-author countries: United States of America 🇺🇸
author keywords: cluster analysis; systems biology; meta-analysis as topic; ARIC; cardiovascular disease
Source: Web Of Science
Added: August 8, 2022

2022 article

Fast Multivariate Probit Estimation via a Two-Stage Composite Likelihood

Ting, B., Wright, F., & Zhou, Y.-H. (2022, February 15). STATISTICS IN BIOSCIENCES, Vol. 2.

By: B. Ting n, F. Wright n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: Composite; Likelihood; Multivariate; Probit; Two-stage; Two-step
Sources: Web Of Science, ORCID
Added: February 15, 2022

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n, A. Planchart n, A. Motsinger-Reif n, S. Cevik n, S. Park n, M. Cowley n, F. Wright n ...

co-author countries: United States of America 🇺🇸
author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Grouping of UVCB Substances with Dose-Response Transcriptomics Data from Human Cell-Based Assays

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 39(3), 388–404.

By: J. House n, F. Grimm*, W. Klaren*, A. Dalzell*, S. Kuchi*, S. Zhang*, K. Lenz*, P. Boogaard ...

co-author countries: Belgium 🇧🇪 Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Biological Assay; Endothelial Cells; Humans; Induced Pluripotent Stem Cells; Petroleum; Transcriptome
Sources: Web Of Science, ORCID
Added: August 29, 2022

2022 journal article

Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

AMERICAN JOURNAL OF HUMAN GENETICS, 109(9), 1638–1652.

By: C. Harlow*, J. Gandawijaya*, R. Bamford*, E. Martin*, A. Wood*, P. Most*, T. Tanaka*, H. Leonard* ...

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Anemia / drug therapy; Anemia / genetics; Coronary Artery Disease / genetics; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Myocardial Infarction / genetics; Renal Insufficiency, Chronic / genetics
Source: Web Of Science
Added: November 21, 2022

2022 journal article

Leveraging TOPMed imputation server and constructing a cohort-specific imputation reference panel to enhance genotype imputation among cystic fibrosis patients

HUMAN GENETICS AND GENOMICS ADVANCES, 3(2).

By: Q. Sun*, W. Liu*, J. Rosen*, L. Huang*, R. Pace*, H. Dang*, P. Gallins n, E. Blue* ...

co-author countries: Canada 🇨🇦 France 🇫🇷 United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: May 10, 2022

2022 journal article

MagicalRsq: Machine-learning-based genotype imputation quality calibration

AMERICAN JOURNAL OF HUMAN GENETICS, 109(11), 1986–1997.

By: Q. Sun*, Y. Yang*, J. Rosen*, M. Jiang*, J. Chen*, W. Liu*, J. Wen*, L. Raffield* ...

co-author countries: Italy 🇮🇹 United States of America 🇺🇸
MeSH headings : Humans; Genome-Wide Association Study / methods; Polymorphism, Single Nucleotide / genetics; Calibration; Genotype; Machine Learning
Sources: Web Of Science, ORCID
Added: January 17, 2023

2022 journal article

Model systems and organisms for addressing inter- and intra-species variability in risk assessment

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 132.

By: I. Rusyn*, W. Chiu* & F. Wright n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Mice; Models, Theoretical; Risk Assessment; Toxicokinetics; Uncertainty
Source: Web Of Science
Added: August 15, 2022

2022 journal article

Pleiotropic modifiers of age-related diabetes and neonatal intestinal obstruction in cystic fibrosis

AMERICAN JOURNAL OF HUMAN GENETICS, 109(10), 1894–1908.

By: M. Aksit*, H. Ling*, R. Pace*, K. Raraigh*, F. Onchiri, A. Faino, K. Pagel*, E. Pugh* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Diabetes Mellitus / genetics; Genome-Wide Association Study; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction / complications; Intestinal Obstruction / genetics
Sources: Web Of Science, ORCID
Added: November 21, 2022

2022 journal article

Spatial and Temporal Analysis of Impacts of Hurricane Florence on Criteria Air Pollutants and Air Toxics in Eastern North Carolina

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19(3).

By: S. Bhandari*, G. Casillas*, N. Aly*, R. Zhu*, G. Newman*, F. Wright n, A. Miller*, G. Adler, I. Rusyn*, W. Chiu*

co-author countries: United States of America 🇺🇸
author keywords: air pollution; geospatial analyses; criteria pollutants; volatile organic compounds
MeSH headings : Air Pollutants / analysis; Air Pollution / analysis; Cyclonic Storms; Environmental Monitoring; North Carolina; Vehicle Emissions / analysis
Source: Web Of Science
Added: March 7, 2022

2022 article

TwinEQTL: ultrafast and powerful association analysis for eQTL and GWAS in twin studies

Xia, K., Shabalin, A. A., Yin, Z., Chung, W., Sullivan, P. F., Wright, F. A., … Zou, F. (2022, June 11). GENETICS.

co-author countries: United States of America 🇺🇸
author keywords: Twin; eQTL; GWAS
MeSH headings : Humans; Gene Frequency; Genome-Wide Association Study / methods; Linear Models; Polymorphism, Single Nucleotide; Quantitative Trait Loci
Source: Web Of Science
Added: July 11, 2022

2021 journal article

Application of Edible Montmorillonite Clays for the Adsorption and Detoxification of Microcystin

ACS APPLIED BIO MATERIALS, 4(9), 7254–7265.

By: M. Wang*, K. Rivenbark*, J. Gong n, F. Wright n & T. Phillips

co-author countries: United States of America 🇺🇸

Contributors: M. Wang*, K. Rivenbark*, J. Gong n, F. Wright n & T. Phillips

author keywords: adsorption isotherm; Hydra vulgaris; Lemna minor; Caenorhabditis elegans; molecular model; dietary sorbent
MeSH headings : Adsorption; Animals; Bentonite / chemistry; Caenorhabditis elegans; Charcoal / pharmacology; Clay / chemistry; Hydra; Microcystins / chemistry
Sources: Web Of Science, ORCID
Added: October 12, 2021

2021 journal article

Data Processing Workflow to Identify Structurally Related Compounds in Petroleum Substances Using Ion Mobility Spectrometry-Mass Spectrometry

ENERGY & FUELS, 35(13), 10529–10539.

By: A. Roman-Hubers*, A. Cordova*, N. Aly*, T. McDonald*, D. Lloyd n, F. Wright n, E. Baker n, W. Chiu*, I. Rusyn*

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: July 26, 2021

2021 journal article

Environmental impacts of Hurricane Florence flooding in eastern North Carolina: temporal analysis of contaminant distribution and potential human health risks

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 31(5), 810–822.

By: N. Aly*, G. Casillas*, Y. Luo*, T. McDonald*, T. Wade*, R. Zhu*, G. Newman*, D. Lloyd n ...

co-author countries: United States of America 🇺🇸
author keywords: Disaster research response; Superfund; Chemical contaminants
MeSH headings : Cyclonic Storms; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Humans; Metals; North Carolina / epidemiology; Soil
Source: Web Of Science
Added: May 24, 2021

2021 journal article

Grouping of UVCB Substances with New Approach Methodologies (NAMs) Data

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 38(1), 123–137.

By: J. House n, F. Grimm*, W. Klaren*, A. Dalzell*, S. Kuchi*, S. Zhang*, K. Lenz*, P. Boogaard* ...

co-author countries: Belgium 🇧🇪 Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Netherlands 🇳🇱 United States of America 🇺🇸

Contributors: J. House n, F. Grimm*, W. Klaren*, A. Dalzell*, S. Kuchi*, S. Zhang*, K. Lenz*, P. Boogaard* ...

MeSH headings : Animal Testing Alternatives / methods; Hazardous Substances / chemistry; Hazardous Substances / toxicity; Humans; Induced Pluripotent Stem Cells / drug effects; Petroleum / analysis; Petroleum / toxicity; Toxicity Tests / methods
Sources: Web Of Science, ORCID
Added: March 15, 2021

2021 journal article

Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene

CHEMICAL RESEARCH IN TOXICOLOGY, 34(11), 2375–2383.

By: L. Erber*, S. Goodman*, F. Wright n, W. Chiu*, N. Tretyakova* & I. Rusyn*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Butadienes / administration & dosage; Butadienes / metabolism; Butadienes / urine; Chromatography, Liquid; DNA Adducts / administration & dosage; DNA Adducts / metabolism; DNA Adducts / urine; Female; Inhalation Exposure; Male; Mice; Mice, Inbred Strains; Nanotechnology; Spectrometry, Mass, Electrospray Ionization
Source: Web Of Science
Added: November 29, 2021

2021 journal article

Potential Human Health Hazard of Post-Hurricane Harvey Sediments in Galveston Bay and Houston Ship Channel: A Case Study of Using In Vitro Bioactivity Data to Inform Risk Management Decisions

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(24).

co-author countries: United States of America 🇺🇸
author keywords: new approach methods (NAMs); environmental mixtures; disaster research
MeSH headings : Bays; Cyclonic Storms; Disasters; Environmental Monitoring; Geologic Sediments; Humans; Polycyclic Aromatic Hydrocarbons / analysis; Risk Management; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID
Added: December 20, 2021

2021 journal article

Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-Derived cardiomyocytes

FOOD AND CHEMICAL TOXICOLOGY, 149.

By: Y. Luo*, Z. Chen*, A. Blanchette*, Y. Zhou n, F. Wright n, E. Baker n, W. Chiu*, I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: Cardiovascular; Heart rate; QT interval; Theophylline; Adenine; Azelate
MeSH headings : Calcium / metabolism; Cell Differentiation; Cell Survival / drug effects; Drug-Related Side Effects and Adverse Reactions; Energy Drinks / analysis; Heart Diseases / chemically induced; Humans; Induced Pluripotent Stem Cells / drug effects; Myocytes, Cardiac / drug effects; Risk Assessment
Sources: Web Of Science, ORCID
Added: February 4, 2021

2021 journal article

Risk Characterization of Environmental Samples Using In Vitro Bioactivity and Polycyclic Aromatic Hydrocarbon Concentrations Data

TOXICOLOGICAL SCIENCES, 179(1), 108–120.

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
author keywords: polycyclic aromatic hydrocarbons; mixtures toxicology; in vitro models; iPSC; humanized models; human risk assessment; risk assessment; new approach methods; bioactivity; spatial analysis
MeSH headings : Cyclonic Storms; Endothelial Cells; Environmental Exposure / adverse effects; Environmental Monitoring; Humans; Polycyclic Aromatic Hydrocarbons / toxicity
Source: Web Of Science
Added: March 15, 2021

2021 personal communication

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).

co-author countries: United States of America 🇺🇸

Contributors: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
Sources: Web Of Science, ORCID
Added: March 22, 2021

2020 journal article

A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes

CLINICAL PHARMACOLOGY & THERAPEUTICS, 107(6), 1383–1393.

By: A. Etheridge*, P. Gallins n, D. Jima n, K. Broadaway*, M. Ratain*, E. Schuetz*, E. Schadt*, A. Schroder* ...

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacology; Child; Child, Preschool; Female; Gene Expression Regulation / genetics; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Hypolipidemic Agents / pharmacology; Infant; Liver / metabolism; Male; Middle Aged; Phenotype; Proprotein Convertase 9 / genetics; Quantitative Trait Loci / genetics; Receptors, G-Protein-Coupled / genetics; Sex Factors; Young Adult
Sources: Web Of Science, ORCID
Added: February 10, 2020

2020 journal article

Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms

PLOS COMPUTATIONAL BIOLOGY, 16(9).

co-author countries: United States of America 🇺🇸
MeSH headings : Algorithms; Cell Line; Estrogens / classification; Estrogens / metabolism; Humans; Machine Learning; Receptors, Estrogen / metabolism
Source: Web Of Science
Added: October 26, 2020

2020 journal article

Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells

SMALL, 16(21).

By: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

co-author countries: United States of America 🇺🇸

Contributors: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

author keywords: nanotoxicity; silver nanoparticles; transcriptomics
MeSH headings : Gene Expression / drug effects; Hepatocytes / drug effects; Humans; Metal Nanoparticles / chemistry; Silver; Surface Properties; Time Factors
Sources: Web Of Science, ORCID
Added: April 14, 2020

2020 personal communication

Questioning Existing Cancer Hazard Evaluation Standards in the Name of Statistics

Rusyn, I., Chiu, W. A., & Wright, F. A. (2020, October).

By: I. Rusyn*, W. Chiu* & F. Wright n

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
MeSH headings : Biological Assay; Glycine / analogs & derivatives; Humans; Neoplasms / epidemiology; Reference Standards
Source: Web Of Science
Added: December 14, 2020

2020 journal article

Rapid Hazard Characterization of Environmental Chemicals Using a Compendium of Human Cell Lines from Different Organs

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 37(4), 623–638.

By: Z. Chen*, Y. Liu, F. Wright, W. Chiu & I. Rusyn

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: February 15, 2021

2020 journal article

Systematic Comparisons for Composition Profiles, Taxonomic Levels, and Machine Learning Methods for Microbiome-Based Disease Prediction

FRONTIERS IN MOLECULAR BIOSCIENCES, 7.

By: K. Song n, F. Wright n & Y. Zhou n

co-author countries: United States of America 🇺🇸
author keywords: phenotype prediction; machine learning method; k-mers; operational taxonomic unit (OTU); amplicon sequence variant (ASV); phylogenetic analysis
Sources: Web Of Science, ORCID
Added: January 19, 2021

2020 journal article

The GTEx Consortium atlas of genetic regulatory effects across human tissues

SCIENCE, 369(6509), 1318–1330.

By: F. Aguet, A. Barbeira, R. Bonazzola, A. Brown, S. Castel, B. Jo, S. Kasela, S. Kim-Hellmuth ...

MeSH headings : Datasets as Topic; Disease / genetics; Female; Gene Expression Regulation; Genome-Wide Association Study; Humans; Male; Organ Specificity; Quantitative Trait Loci; Sequence Analysis, RNA
Source: Web Of Science
Added: November 16, 2020

2019 article

Development of the Texas A&M Superfund Research Program Computational Platform for Data Integration, Visualization, and Analysis

29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, PT A, Vol. 46, pp. 967–972.

co-author countries: United States of America 🇺🇸
author keywords: Data analytics; data integration; statistical analysis; collaborative networks
Source: Web Of Science
Added: November 25, 2019

2019 journal article

Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization

PLOS ONE, 14(10).

co-author countries: United States of America 🇺🇸

Contributors: M. Onel*, B. Beykal*, K. Ferguson*, W. Chiu*, T. McDonald*, L. Zhou*, J. House n, F. Wright n ...

MeSH headings : Chemistry Techniques, Analytical / methods; Gas Chromatography-Mass Spectrometry; Petroleum / analysis; Principal Component Analysis; Reference Standards; Sample Size
Sources: Web Of Science, ORCID
Added: June 1, 2020

2019 journal article

Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 101, 91–102.

By: F. Grimm*, J. House n, M. Wilson*, O. Sirenko*, Y. Iwata*, F. Wright n, N. Ball, I. Rusyn*

co-author countries: United States of America 🇺🇸

Contributors: F. Grimm*, J. House n, M. Wilson*, O. Sirenko*, Y. Iwata*, F. Wright n, N. Ball, I. Rusyn*

author keywords: New assessment methodologies; Glycol ethers; In vitro; ToxPi; Read-across; Safety assessment
MeSH headings : Animals; Cell Line; Ethers / classification; Ethers / toxicity; Glycols / classification; Glycols / toxicity; Humans; Risk Assessment; Solvents / classification; Solvents / toxicity; Toxicity Tests
Sources: Web Of Science, ORCID
Added: April 22, 2019

2019 journal article

Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse

CHEMICAL RESEARCH IN TOXICOLOGY, 32(5), 887–898.

By: L. Lewis*, B. Borowa-Mazgaj*, A. Conti*, G. Chappell*, Y. Luo*, W. Bodnar*, K. Konganti*, F. Wright n ...

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Butadienes / toxicity; Carcinogens, Environmental / toxicity; DNA Adducts / chemistry; DNA Adducts / genetics; DNA Adducts / metabolism; DNA Methylation / drug effects; Epigenesis, Genetic / drug effects; Guanine / analogs & derivatives; Guanine / chemistry; Histones / metabolism; Kidney / drug effects; Liver / drug effects; Lung / drug effects; Male; Mice; Mutagens / toxicity
Source: Web Of Science
Added: June 17, 2019

2019 journal article

Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene

ENVIRONMENTAL HEALTH PERSPECTIVES, 127(6).

By: Y. Luo*, J. Cichocki*, N. Hsieh*, L. Lewis*, F. Wright n, D. Threadgill*, W. Chiu*, I. Rusyn*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Collaborative Cross Mice; Glutathione / analogs & derivatives; Glutathione / metabolism; Hepatitis A Virus Cellular Receptor 1 / genetics; Hepatitis A Virus Cellular Receptor 1 / metabolism; Kidney / drug effects; Kidney Diseases / chemically induced; Kidney Diseases / metabolism; Liver / drug effects; Male; Risk Assessment / methods; Species Specificity; Tetrachloroethylene / metabolism; Tetrachloroethylene / pharmacokinetics; Tetrachloroethylene / toxicity; Toxicokinetics
Source: Web Of Science
Added: July 29, 2019

2018 journal article

A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(4), 441–452.

By: F. Grimm*, A. Blanchette*, J. House n, K. Ferguson*, N. Hsieh*, C. Dalaijamts*, A. Wright*, B. Anson* ...

co-author countries: United States of America 🇺🇸

Contributors: F. Grimm*, A. Blanchette*, J. House n, K. Ferguson*, N. Hsieh*, C. Dalaijamts*, A. Wright*, B. Anson* ...

MeSH headings : Cardiotoxicity / genetics; Cardiovascular Agents / pharmacology; Cardiovascular Agents / toxicity; Cell Differentiation / drug effects; Cell Differentiation / genetics; Female; Healthy Volunteers; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / drug effects; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Phenotype; Reproducibility of Results
Sources: Web Of Science, ORCID
Added: December 10, 2018

2018 journal article

A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure

Cell Reports, 23(2), 327–336.

By: T. Frayling, R. Beaumont, S. Jones, H. Yaghootkar, M. Tuke, K. Ruth, F. Casanova, B. West ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity

American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.

By: D. Polineni, H. Dang, P. Gallins, L. Jones, R. Pace, J. Stonebraker, L. Commander, J. Krenicky ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

An empirical Bayes approach for multiple tissue eQTL analysis

Biostatistics (Oxford, England), 19(3), 391–406.

By: G. Li*, A. Shabalin*, I. Rusyn, F. Wright n & A. Nobel*

co-author countries: United States of America 🇺🇸
MeSH headings : Bayes Theorem; Biostatistics / methods; Gene Expression; Genomics / methods; Genotyping Techniques / methods; Humans; Models, Statistical; Quantitative Trait Loci
Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Computation of ancestry scores with mixed families and unrelated individuals

BIOMETRICS, 74(1), 155–164.

By: Y. Zhou n, J. Marron* & F. Wright n

co-author countries: United States of America 🇺🇸
author keywords: Genetic association; Population stratification; Principal components
MeSH headings : Cystic Fibrosis / genetics; Family; Genome; Genotype; Humans; Models, Genetic; Pedigree; Principal Component Analysis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Estimation of cis-eQTL effect sizes using a log of linear model

BIOMETRICS, 74(2), 616–625.

By: J. Palowitch*, A. Shabalin*, Y. Zhou n, A. Nobel* & F. Wright n

co-author countries: United States of America 🇺🇸
author keywords: eQTL analyses; EQTL effect size; Multiple testing; Nonlinear regression
MeSH headings : Algorithms; Alleles; Gene Expression; Humans; Linear Models; Quantitative Trait Loci; Statistics as Topic
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues

BMC Bioinformatics, 19.

By: G. Li, D. Jima, F. Wright & A. Nobel

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes

Frontiers in Cell and Developmental Biology, 6(SEP), 107.

By: J. House n, M. Mendez*, R. Maguire n, S. Gonzalez-Nahm*, Z. Huang*, J. Daniels*, S. Murphy*, B. Fuemmeler*, F. Wright n, C. Hoyo n

co-author countries: United States of America 🇺🇸

Contributors: J. House n, M. Mendez*, R. Maguire n, S. Gonzalez-Nahm*, Z. Huang*, J. Daniels*, S. Murphy*, B. Fuemmeler*, F. Wright n, C. Hoyo n

Sources: NC State University Libraries, ORCID
Added: January 21, 2019

2018 journal article

Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp nov.

SYSTEMATIC AND APPLIED MICROBIOLOGY, 41(5), 460–472.

By: D. Singleton*, J. Lee*, A. Dickey n, A. Stroud*, E. Scholl n, F. Wright n, M. Aitken*

co-author countries: United States of America 🇺🇸
author keywords: Acidovorax; Phenanthrene; Polycyclic aromatic hydrocarbons
MeSH headings : Biodegradation, Environmental; Comamonadaceae / chemistry; Comamonadaceae / classification; Comamonadaceae / genetics; Comamonadaceae / physiology; DNA, Bacterial; Genes, Bacterial; Genome, Bacterial / genetics; Metabolic Networks and Pathways / genetics; North Carolina; Phenanthrenes / metabolism; Phylogeny; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; Soil Pollutants / metabolism
Source: Web Of Science
Added: October 16, 2018

2018 journal article

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse

MAMMALIAN GENOME, 29(1-2), 168–181.

By: A. Venkatratnam*, J. House n, K. Konganti*, C. McKenney n, D. Threadgill*, W. Chiu*, D. Aylor n, F. Wright n, I. Rusyn*

co-author countries: United States of America 🇺🇸

Contributors: A. Venkatratnam*, J. House n, K. Konganti*, C. McKenney n, D. Threadgill*, W. Chiu*, D. Aylor n, F. Wright n, I. Rusyn*

MeSH headings : Animals; Dose-Response Relationship, Drug; Genetics, Population; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Mice; Transcription, Genetic / drug effects; Transcriptome / genetics; Trichloroacetic Acid / metabolism; Trichloroethylene / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models

BMC Bioinformatics, 19.

By: S. Marvel, K. To, F. Grimm, F. Wright, I. Rusyn & D. Reif

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

A Pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics

Frontiers in Genetics, 8.

By: J. House, F. Grimm, D. Jima, Y. Zhou, I. Rusyn & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

A procedure to detect general association based on concentration of ranks

Stat, 6(1), 88–101.

By: P. Rudra, Y. Zhou & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

A tiered, Bayesian approach to estimating population variability for regulatory decision-making

Altex-Alternatives to Animal Experimentation, 34(3), 377–388.

By: W. Chiu, F. Wright & I. Rusyn

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Adrenal-derived stress hormones modulate ozone-induced lung injury and inflammation

TOXICOLOGY AND APPLIED PHARMACOLOGY, 329, 249–258.

By: A. Henriquez*, J. House n, D. Miller*, S. Snow*, A. Fisher*, H. Ren*, M. Schladweiler*, A. Ledbetter*, F. Wright n, U. Kodavanti*

co-author countries: United States of America 🇺🇸

Contributors: A. Henriquez*, J. House n, D. Miller*, S. Snow*, A. Fisher*, H. Ren*, M. Schladweiler*, A. Ledbetter*, F. Wright n, U. Kodavanti*

author keywords: Ozone; Lung; Stress hormones; Adrenalectomy; RNAseq
MeSH headings : Adrenal Cortex / metabolism; Adrenal Cortex / surgery; Adrenal Medulla / metabolism; Adrenal Medulla / surgery; Adrenalectomy; Animals; Corticosterone / blood; Cytokines / metabolism; Disease Models, Animal; Epinephrine / blood; Gene Expression Regulation; Inflammation Mediators / metabolism; Lung / metabolism; Lung / pathology; Lung Injury / blood; Lung Injury / chemically induced; Lung Injury / genetics; Lung Injury / prevention & control; Male; Neutrophils / metabolism; Oxidative Stress; Ozone; Pneumonia / blood; Pneumonia / chemically induced; Pneumonia / genetics; Pneumonia / pathology; Pneumonia / prevention & control; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats, Inbred WKY; Signal Transduction; Stress, Physiological / genetics; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

An improved and explicit surrogate variable analysis procedure by coefficient adjustment

BIOMETRIKA, 104(2), 303–316.

By: S. Lee*, W. Sun*, F. Wright n & F. Zou*

co-author countries: United States of America 🇺🇸
author keywords: Batch effect; High-dimensional data; Principal component analysis; Surrogate variable analysis
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Conditional eQTL analysis reveals allelic heterogeneity of gene expression

HUMAN MOLECULAR GENETICS, 26(8), 1444–1451.

By: R. Jansen*, J. Hottenga*, M. Nivard*, A. Abdellaoui*, B. Laport*, E. Geus*, F. Wright n, B. Penninx*, D. Boomsma*

co-author countries: Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Alleles; Blood; Gene Expression Profiling; Gene Expression Regulation; Genetic Heterogeneity; Genome-Wide Association Study; Humans; Phenotype; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics; Transcriptome / genetics
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Dynamic landscape and regulation of RNA editing in mammals

Nature, 550(7675), 249–254.

By: M. Tan*, Q. Li*, R. Shanmugam*, R. Piskol*, J. Kohler*, A. Young*, K. Liu*, R. Zhang* ...

co-author countries: Australia 🇦🇺 Czechia 🇨🇿 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 Singapore 🇸🇬 United States of America 🇺🇸
MeSH headings : Adenosine Deaminase / genetics; Adenosine Deaminase / metabolism; Animals; Female; Genotype; HEK293 Cells; Humans; Male; Mice; Muscles / metabolism; Nuclear Proteins / metabolism; Organ Specificity / genetics; Primates / genetics; Proteolysis; RNA Editing / genetics; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism; Spatio-Temporal Analysis; Species Specificity; Transcriptome / genetics
Sources: Crossref, ORCID
Added: January 25, 2020

2017 journal article

Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism

TOXICOLOGICAL SCIENCES, 158(1), 48–62.

By: A. Venkatratnam*, S. Furuya*, O. Kosyk*, A. Gold*, W. Bodnar*, K. Konganti*, D. Threadgill*, K. Gillespie n ...

co-author countries: United States of America 🇺🇸
author keywords: population; trichloroethylene; mouse
MeSH headings : Alcohol Dehydrogenase / biosynthesis; Aldehyde Dehydrogenase / biosynthesis; Animals; Dose-Response Relationship, Drug; Enzyme Induction; Female; Gene-Environment Interaction; Kidney / drug effects; Liver / drug effects; Liver / enzymology; Liver / metabolism; Male; Mice; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors / genetics; Peroxisome Proliferator-Activated Receptors / metabolism; Quantitative Trait Loci; Species Specificity; Toxicokinetics; Trichloroethylene / blood; Trichloroethylene / pharmacokinetics; Trichloroethylene / toxicity
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues

AMERICAN JOURNAL OF HUMAN GENETICS, 100(4), 605–616.

By: X. Liu*, H. Finucane*, A. Gusev*, G. Bhatia*, S. Gazal*, L. O'Connor*, B. Bulik-Sullivan*, F. Wright n ...

co-author countries: Sweden 🇸🇪 United States of America 🇺🇸
MeSH headings : Anxiety / genetics; Computer Simulation; Depression / genetics; Gene Expression Regulation; Humans; Linkage Disequilibrium; Organ Specificity; Quantitative Trait Loci; Regression Analysis; Twins / genetics
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Genetic effects on gene expression across human tissues

Nature, 550(7675), 204–213.

By: F. Aguet, A. Brown*, S. Castel, J. Davis, Y. He*, B. Jo, P. Mohammadi, Y. Park ...

co-author countries: United States of America 🇺🇸
MeSH headings : Alleles; Chromosomes, Human / genetics; Disease / genetics; Female; Gene Expression Profiling; Gene Expression Regulation / genetics; Genetic Variation; Genome, Human / genetics; Genotype; Humans; Male; Organ Specificity / genetics; Quantitative Trait Loci / genetics
Sources: Crossref, ORCID
Added: December 19, 2020

2017 journal article

Genetic effects on gene expression across human tissues

Nature, 550(7675), 204-.

By: F. Aguet, A. Brown, S. Castel, J. Davis, Y. He, B. Jo, P. Mohammadi, Y. Park ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Landscape of X chromosome inactivation across human tissues

Nature, 550(7675), 244–248.

co-author countries: United States of America 🇺🇸
MeSH headings : Chromosomes, Human, X / genetics; Female; Genes, X-Linked / genetics; Genome, Human / genetics; Genomics; Humans; Male; Organ Specificity / genetics; Phenotype; Sequence Analysis, RNA; Single-Cell Analysis; Transcriptome / genetics; X Chromosome Inactivation / genetics
Source: Crossref
Added: December 19, 2020

2017 journal article

The impact of rare variation on gene expression across tissues

Nature, 550(7675), 239–243.

By: X. Li*, Y. Kim*, E. Tsang*, J. Davis*, F. Damani*, C. Chiang*, G. Hess*, Z. Zappala* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Bayes Theorem; Female; Gene Expression Profiling; Genetic Variation / genetics; Genome, Human / genetics; Genomics; Genotype; Humans; Male; Models, Genetic; Organ Specificity / genetics; Sequence Analysis, RNA
Sources: Crossref, ORCID
Added: January 25, 2020

2016 journal article

A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

GREEN CHEMISTRY, 18(16), 4407–4419.

By: F. Grimm*, Y. Iwata*, O. Sirenko*, G. Chappell*, F. Wright n, D. Reif n, J. Braisted*, D. Gerhold* ...

co-author countries: Belgium 🇧🇪 Germany 🇩🇪 United States of America 🇺🇸

Contributors: F. Grimm*, Y. Iwata*, O. Sirenko*, G. Chappell*, F. Wright n, D. Reif n, J. Braisted*, D. Gerhold* ...

Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Erratum: Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Scientific Reports, 6(1), 19384.

By: J. Yang, T. Huang, F. Petralia, Q. Long, B. Zhang, C. Argmann, Y. Zhao, C. Mobbs ...

Source: Crossref
Added: January 4, 2021

2016 journal article

Gene expression in major depressive disorder

Molecular Psychiatry, 21(3), 339–347.

By: R. Jansen, B. Penninx, V. Madar, K. Xia, Y. Milaneschi, J. Hottenga, A. Hammerschlag, A. Beekman ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium

PLoS One, 11(12).

By: X. Tian, K. Patel, J. Ridpath, Y. Chen, Y. Zhou, D. Neo, J. Clement, M. Takata ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Integrative approaches for large-scale transcriptome-wide association studies

Nature Genetics, 48(3), 245–252.

By: A. Gusev*, A. Ko*, H. Shi*, G. Bhatia*, W. Chung*, B. Penninx*, R. Jansen*, E. de Geus ...

co-author countries: Finland 🇫🇮 Netherlands 🇳🇱 Sweden 🇸🇪 United States of America 🇺🇸
MeSH headings : Animals; Gene Expression Regulation / genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Mice; Obesity / genetics; Obesity / pathology; Phenotype; Quantitative Trait Loci / genetics; Transcriptome / genetics
Source: Crossref
Added: February 24, 2020

2016 journal article

Integrative approaches for large-scale transcriptome-wide association studies

Nature Genetics, 48(3), 245–252.

By: A. Gusev, A. Ko, H. Shi, G. Bhatia, W. Chung, B. Penninx, R. Jansen, E. Geus ...

Source: NC State University Libraries
Added: August 6, 2018

2016 conference paper

Poster: risk-based attack surface approximation

Symposium and Bootcamp on the Science of Security, 121–123.

By: C. Theisen & L. Williams

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

The projack: a resampling approach to correct for ranking bias in high-throughput studies

Biostatistics (Oxford, England), 17(1), 54–64.

By: Y. Zhou & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Consistent testing for recurrent genomic aberrations

BIOMETRIKA, 102(4), 783–796.

By: V. Walter*, F. Wright n & A. Nobel*

co-author countries: United States of America 🇺🇸
author keywords: Consistency; DNA copy number; DNA methylation; Genome-wide association study; Hypothesis testing
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Erratum: Gene expression in major depressive disorder

Molecular Psychiatry, 21(3), 444–444.

By: R. Jansen, B. Penninx*, V. Madar, K. Xia, Y. Milaneschi*, J. Hottenga, A. Hammerschlag*, A. Beekman ...

co-author countries: Netherlands 🇳🇱
Source: Crossref
Added: August 28, 2020

2015 journal article

Erratum: Prediction of human population responses to toxic compounds by a collaborative competition

Nature Biotechnology, 33(10), 1109–1109.

By: F. Eduati, L. Mangravite, T. Wang*, H. Tang, J. Bare, R. Huang, T. Norman, M. Kellen ...

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: February 24, 2020

2015 journal article

Gene Expression in Transformed Lymphocytes Reveals Variation in Endomembrane and HLA Pathways Modifying Cystic Fibrosis Pulmonary Phenotypes

The American Journal of Human Genetics, 96(2), 318–328.

By: W. O’Neal*, P. Gallins*, R. Pace*, H. Dang*, W. Wolf*, L. Jones*, X. Guo*, Y. Zhou n ...

co-author countries: Canada 🇨🇦 China 🇨🇳 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Cystic Fibrosis / genetics; Cystic Fibrosis / pathology; Endoplasmic Reticulum Stress / genetics; Gene Expression Profiling; Genes, MHC Class I / genetics; Genetic Variation; Humans; Linear Models; Phenotype; Receptors, Lysophosphatidic Acid / genetics; Sequence Deletion / genetics
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Gene expression in major depressive disorder

Molecular Psychiatry, 21(3), 339–347.

By: R. Jansen*, B. Penninx*, V. Madar*, K. Xia*, Y. Milaneschi*, J. Hottenga*, A. Hammerschlag*, A. Beekman* ...

co-author countries: Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Adult; Anxiety Disorders / genetics; Cross-Sectional Studies; Depressive Disorder, Major / diagnosis; Depressive Disorder, Major / genetics; Female; Gene Expression / genetics; Gene Expression Regulation / genetics; Genetic Predisposition to Disease / genetics; Genome-Wide Association Study; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Killer Cells, Natural / metabolism; Longitudinal Studies; Male; Middle Aged; Polymorphism, Single Nucleotide / genetics; Signal Transduction / genetics
Source: Crossref
Added: August 28, 2020

2015 journal article

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Nature Communications, 6(1).

By: H. Corvol*, S. Blackman*, P. Boëlle*, P. Gallins*, R. Pace*, J. Stonebraker*, F. Accurso*, A. Clement* ...

co-author countries: Canada 🇨🇦 France 🇫🇷 United States of America 🇺🇸
MeSH headings : Adolescent; Adult; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral / genetics; Child; Cystic Fibrosis / genetics; Cystic Fibrosis / metabolism; Cystic Fibrosis / pathology; Female; Genome-Wide Association Study; Humans; Lung / metabolism; Lung / pathology; Male; Middle Aged; Mucin-4 / genetics; Mucins / genetics; Severity of Illness Index; Transcription Factors / genetics; Young Adult
Source: Crossref
Added: February 5, 2020

2015 journal article

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Nature Communications, 6.

By: H. Corvol, S. Blackman, P. Boelle, P. Gallins, R. Pace, J. Stonebraker, F. Accurso, A. Clement ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Hypothesis testing at the extremes: fast and robust association for high-throughput data

BIOSTATISTICS, 16(3), 611–625.

By: Y. Zhou n & F. Wright n

co-author countries: United States of America 🇺🇸
author keywords: Density approximation; Exact testing; Permutation
MeSH headings : Biostatistics; Breast Neoplasms / genetics; Computer Simulation; Cystic Fibrosis / genetics; Databases, Nucleic Acid / statistics & numerical data; Female; High-Throughput Nucleotide Sequencing / statistics & numerical data; High-Throughput Screening Assays / statistics & numerical data; Humans; Likelihood Functions; Linear Models; Polymorphism, Single Nucleotide; Sample Size; Software
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

By: J. Rager*, S. Tilley*, S. Tulenko*, L. Smeester*, P. Ray*, A. Yosim*, J. Currier*, M. Ishida* ...

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
MeSH headings : Adult; Aged; Arsenic / metabolism; Arsenic / toxicity; Cell Transformation, Neoplastic / chemically induced; DNA Methylation / drug effects; DNA Methylation / genetics; Female; Humans; Middle Aged; Urinary Bladder Neoplasms / chemically induced; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / pathology; Urothelium / cytology; Urothelium / drug effects; Young Adult
Source: Crossref
Added: February 5, 2020

2015 journal article

Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

By: J. Rager, S. Tilley, S. Tulenko, L. Smeester, P. Ray, A. Yosim, J. Currier, M. Ishida ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

In vitro screening for population variability in toxicity of pesticide-containing mixtures

ENVIRONMENT INTERNATIONAL, 85, 147–155.

co-author countries: Jordan 🇯🇴 United States of America 🇺🇸

Contributors: N. Abdo*, B. Wetmore*, G. Chappell*, D. Shea n, F. Wright n & I. Rusyn*

author keywords: Pesticide; Mixture; Population
MeSH headings : Black People / genetics; Cell Culture Techniques; Cell Line; Cell Survival / drug effects; Cell Survival / genetics; Complex Mixtures / analysis; Complex Mixtures / toxicity; Dose-Response Relationship, Drug; Genome-Wide Association Study; Genotype; Hazardous Substances / analysis; Hazardous Substances / toxicity; Humans; Hydrocarbons, Chlorinated / analysis; Hydrocarbons, Chlorinated / toxicity; Multivariate Analysis; Pesticides / analysis; Pesticides / toxicity; Polymorphism, Genetic; Reproducibility of Results; White People / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466.

By: N. Abdo*, M. Xia*, C. Brown*, O. Kosyk*, R. Huang*, S. Sakamuru*, Y. Zhou n, J. Jack* ...

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
MeSH headings : Cell Line, Tumor; Genome-Wide Association Study / methods; Genotype; Humans; Risk Assessment; Toxicity Tests / methods
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Prediction of human population responses to toxic compounds by a collaborative competition

Nature Biotechnology, 33(9), 933–940.

By: F. Eduati, L. Mangravite, T. Wang, H. Tang, J. Bare, R. Huang, T. Norman, M. Kellen ...

co-author countries: Spain 🇪🇸
MeSH headings : Computer Simulation; Dose-Response Relationship, Drug; Genetic Predisposition to Disease / genetics; Genetics, Population; Hazardous Substances / toxicity; High-Throughput Screening Assays / methods; Humans; Incidence; Lymphocytes / cytology; Lymphocytes / drug effects; Lymphocytes / physiology; Models, Genetic; Risk Assessment / methods; Toxicity Tests / methods
Source: Crossref
Added: February 24, 2020

2015 journal article

Prediction of human population responses to toxic compounds by a collaborative competition

Nature Biotechnology, 33(9), 933–172.

By: F. Eduati, L. Mangravite, T. Wang, H. Tang, J. Bare, R. Huang, T. Norman, M. Kellen ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Scientific Reports, 5(1), 15145.

By: J. Yang, T. Huang, F. Petralia, Q. Long, B. Zhang, C. Argmann, Y. Zhao, C. Mobbs ...

MeSH headings : Adult; Aged; Aging / genetics; Animals; Cluster Analysis; Computational Biology / methods; Female; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genetic Association Studies; Humans; Male; Mice; Middle Aged; Molecular Sequence Annotation; Mutation; Organ Specificity / genetics; Young Adult
Source: Crossref
Added: January 4, 2021

2015 journal article

The human transcriptome across tissues and individuals

Science, 348(6235), 660–665.

By: M. Mele, P. Ferreira, F. Reverter, D. DeLuca, J. Monlong, M. Sammeth, T. Young, J. Goldmann ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Convergence of sample eigenvalues, eigenvectors, and principal component scores for ultra-high dimensional data

BIOMETRIKA, 101(2), 484–490.

By: S. Lee, F. Zou & F. Wright*

author keywords: High-dimension low sample size data; Principal component analysis; Random matrix
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430–437.

By: F. Wright n, P. Sullivan*, A. Brooks*, F. Zou*, W. Sun*, K. Xia*, V. Madar*, R. Jansen* ...

co-author countries: Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Blood / metabolism; Gene Expression Profiling; Gene Expression Regulation / genetics; Genotype; Humans; Inheritance Patterns / genetics; Likelihood Functions; Netherlands; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics
Source: Crossref
Added: February 5, 2020

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430–437.

By: F. Wright, P. Sullivan, A. Brooks, F. Zou, W. Sun, K. Xia, V. Madar, R. Jansen ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

ENVIRONMENTAL HEALTH PERSPECTIVES, 122(5), 456–463.

By: W. Chiu*, J. Campbell*, H. Clewell*, Y. Zhou n, F. Wright n, K. Guyton*, I. Rusyn*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bayes Theorem; Dichloroacetic Acid / metabolism; Humans; Male; Mice; Trichloroethylene / metabolism; Trichloroethylene / pharmacokinetics
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

The American Journal of Human Genetics, 94(2), 233–245.

By: L. Lange, Y. Hu, H. Zhang, C. Xue, E. Schmidt, Z. Tang, C. Bizon, E. Lange ...

MeSH headings : Adult; Aged; Apolipoproteins E / blood; Apolipoproteins E / genetics; Cholesterol, LDL / genetics; Cohort Studies; Dyslipidemias / blood; Dyslipidemias / genetics; Exome; Female; Follow-Up Studies; Gene Frequency; Genetic Code; Genome-Wide Association Study; Genotype; Humans; Lipase / genetics; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Proprotein Convertase 9; Proprotein Convertases / genetics; Receptors, LDL / genetics; Sequence Analysis, DNA; Serine Endopeptidases / genetics
Source: Crossref
Added: August 28, 2020

2013 journal article

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity

Toxicology and Applied Pharmacology, 273(3), 500–507.

By: O. Sirenko, E. Cromwell, C. Crittenden, J. Wignall*, F. Wright* & I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: iPSC; Calcium flux; Cardiotoxicity; hERG; Phenotypic screening; Predictive toxicology
MeSH headings : Area Under Curve; Cardiotoxins / pharmacology; Cell Survival / drug effects; Cells, Cultured; Drug Evaluation, Preclinical / methods; Drug-Related Side Effects and Adverse Reactions / diagnosis; Heart Diseases / chemically induced; Heart Diseases / diagnosis; Heart Diseases / pathology; High-Throughput Screening Assays; Humans; Induced Pluripotent Stem Cells / drug effects; Induced Pluripotent Stem Cells / metabolism; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / physiology; Phenotype; Risk Assessment
Source: Crossref
Added: August 28, 2020

2013 journal article

Space-time clustering and the permutation moments of quadratic forms

Stat, 2(1), 292–302.

By: Y. Zhou n, G. Mayhew*, Z. Sun*, X. Xu*, F. Zou* & F. Wright n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: exact testing; resampling; statistical computing
Source: Crossref
Added: February 5, 2020

2013 journal article

The Genotype-Tissue Expression (GTEx) project

Nature Genetics, 45(6), 580–585.

By: J. Lonsdale, J. Thomas, M. Salvatore, R. Phillips, E. Lo, S. Shad, R. Hasz*, G. Walters* ...

co-author countries: Switzerland 🇨🇭 Spain 🇪🇸 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Consensus Development Conferences, NIH as Topic; Gene Expression; Gene Expression Profiling; Genome-Wide Association Study; Government Programs / ethics; Government Programs / legislation & jurisprudence; Humans; Molecular Sequence Annotation; Organ Specificity; Quantitative Trait Loci; Tissue Banks; United States
Source: Crossref
Added: August 28, 2020

2013 journal article

The Value of Statistical or Bioinformatics Annotation for Rare Variant Association With Quantitative Trait

Genetic Epidemiology, 37(7), 666–674.

By: A. Byrnes*, M. Wu*, F. Wright*, M. Li* & Y. Li*

co-author countries: United States of America 🇺🇸
author keywords: rare variants; association; weighting; variable selection; variant annotation
MeSH headings : Computational Biology; Genetic Variation / genetics; Genome-Wide Association Study; Genomics; Genotype; Humans; Models, Genetic; Molecular Sequence Annotation; Phenotype; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci
Source: Crossref
Added: August 28, 2020

2013 journal article

Unified Analysis of Secondary Traits in Case–Control Association Studies

Journal of the American Statistical Association, 108(502), 566–576.

By: A. Ghosh*, F. Wright* & F. Zou*

co-author countries: India 🇮🇳 United States of America 🇺🇸
author keywords: GWAS; Profile likelihood; Pseudo-likelihood; Retrospective study; Secondary phenotype; Semiparametric method
Source: Crossref
Added: August 28, 2020

2012 journal article

Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis

Nature Genetics, 44(8), 886–889.

By: M. Emond*, T. Louie*, J. Emerson*, W. Zhao*, R. Mathias*, M. Knowles*, F. Wright*, M. Rieder* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Adolescent; Age of Onset; Child; Child, Preschool; Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Dynactin Complex; Exome; Gene Frequency; Humans; Infant; Infant, Newborn; Linkage Disequilibrium; Microtubule-Associated Proteins / genetics; Phenotype; Polymorphism, Single Nucleotide; Pseudomonas Infections / etiology; Pseudomonas Infections / genetics; Pseudomonas aeruginosa
Source: Crossref
Added: August 28, 2020

2012 journal article

Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

Nature Genetics, 44(5), 562–569.

By: L. Sun*, J. Rommens*, H. Corvol*, W. Li*, X. Li*, T. Chiang*, F. Lin*, R. Dorfman* ...

co-author countries: Canada 🇨🇦 France 🇫🇷 United States of America 🇺🇸
MeSH headings : Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral / genetics; Antiporters / genetics; Cell Membrane / metabolism; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Ileus / genetics; Intestinal Obstruction / etiology; Meconium; Polymorphism, Single Nucleotide / genetics; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers / genetics; Sulfate Transporters
Source: Crossref
Added: August 28, 2020

2011 journal article

A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies

Pediatric Pulmonology, 46(9), 857–869.

By: C. Taylor*, C. Commander*, J. Collaco*, L. Strug*, W. Li*, F. Wright*, A. Webel*, R. Pace* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: forced expiratory volume; age effects; severity of illness index
MeSH headings : Adolescent; Child; Chronic Disease; Clinical Trials as Topic; Cystic Fibrosis / genetics; Cystic Fibrosis / mortality; Female; Humans; Male; Multicenter Studies as Topic; Phenotype; Respiratory Function Tests; Severity of Illness Index; Survival Analysis
Source: Crossref
Added: August 28, 2020

2011 journal article

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

Nature Genetics, 43(6), 539–546.

By: F. Wright*, L. Strug*, V. Doshi*, C. Commander*, S. Blackman*, L. Sun*, Y. Berthiaume*, D. Cutler* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
MeSH headings : Adolescent; Adult; Child; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 20; Cystic Fibrosis / genetics; Female; Genetic Linkage; Genome-Wide Association Study; Humans; Lung Diseases / genetics; Male; Phenotype; Quantitative Trait Loci
Source: Crossref
Added: August 28, 2020

2011 journal article

MicroRNA expression in the livers of inbred mice

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 714(1-2), 126–133.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: MicroRNA; Liver; Mouse; Gene expression
MeSH headings : Animals; Gene Expression; Liver / metabolism; Mice; Mice, Inbred Strains / genetics; MicroRNAs / metabolism; Polymorphism, Single Nucleotide
Sources: Crossref, Web Of Science
Added: August 6, 2018

2011 journal article

Nuclear Factor κ-Light Chain-Enhancer of Activated B Cells is Activated by Radiotherapy and is Prognostic for Overall Survival in Patients With Rectal Cancer Treated With Preoperative Fluorouracil-Based Chemoradiotheraphy

International Journal of Radiation Oncology*Biology*Physics, 80(3), 705–711.

By: B. O'Neil*, W. Funkhouser*, B. Calvo*, M. Meyers*, H. Kim*, R. Goldberg*, S. Bernard*, L. Caskey* ...

co-author countries: United States of America 🇺🇸
author keywords: Chemoradiotherapy; NF-kappa B; rectal cancer; prognostic markers; inducible resistance genes; TRAF1; Bcl-2; cIAP-2; interleukin 8
MeSH headings : Adult; Aged; Aged, 80 and over; Combined Modality Therapy / methods; Female; Genes, bcl-2 / genetics; Humans; Inhibitor of Apoptosis Proteins / genetics; Interleukin-8 / genetics; Male; Middle Aged; NF-kappa B / metabolism; Neoplasm Proteins / metabolism; Prognosis; Prospective Studies; Radiation Tolerance / genetics; Rectal Neoplasms / drug therapy; Rectal Neoplasms / genetics; Rectal Neoplasms / metabolism; Rectal Neoplasms / mortality; Rectal Neoplasms / radiotherapy; Retrospective Studies; TNF Receptor-Associated Factor 1 / genetics; Treatment Outcome
Source: Crossref
Added: January 4, 2021

2010 journal article

An approximate Bayesian approach for quantitative trait loci estimation

Computational Statistics & Data Analysis, 54(2), 565–574.

By: Y. Chang*, F. Zou* & F. Wright*

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: August 28, 2020

2010 journal article

Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus

Proceedings of the National Academy of Sciences, 107(10), 4693–4698.

By: P. Shea*, K. Virtaneva*, J. Kupko*, S. Porcella*, W. Barry*, F. Wright*, S. Kobayashi, A. Carmody* ...

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: epithelial growth factor receptor; host pathogen; microarray; Streptococcus pyogenes; transcriptome
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Clathrin-Coated Vesicles / metabolism; Cytokines / metabolism; GTP Phosphohydrolases / genetics; GTP Phosphohydrolases / metabolism; Gene Expression Profiling; Host-Pathogen Interactions; Hyaluronic Acid / metabolism; Macaca fascicularis / genetics; Macaca fascicularis / metabolism; Macaca fascicularis / microbiology; Neutrophils / metabolism; Neutrophils / microbiology; Neutrophils / pathology; Oligonucleotide Array Sequence Analysis; Pharyngitis / genetics; Pharyngitis / microbiology; Pharynx / metabolism; Pharynx / microbiology; Pharynx / pathology; Reverse Transcriptase Polymerase Chain Reaction; Streptococcus pyogenes / genetics; Streptococcus pyogenes / metabolism; Streptococcus pyogenes / physiology
Source: Crossref
Added: August 28, 2020

2010 journal article

Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans

Clinical Pharmacology & Therapeutics, 88(1), 45–51.

By: J. Winnike*, Z. Li*, F. Wright*, J. Macdonald*, T. O'Connell* & P. Watkins*

co-author countries: United States of America 🇺🇸
MeSH headings : Acetaminophen / adverse effects; Acetaminophen / metabolism; Acetaminophen / pharmacology; Adolescent; Adult; Alanine Transaminase / blood; Analgesics, Non-Narcotic / adverse effects; Analgesics, Non-Narcotic / metabolism; Analgesics, Non-Narcotic / pharmacology; Biotransformation; Chemical and Drug Induced Liver Injury / diagnosis; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / urine; Cohort Studies; Data Interpretation, Statistical; Female; Humans; Least-Squares Analysis; Liver Function Tests; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Young Adult
Source: Crossref
Added: August 28, 2020

2009 journal article

A robust QTL mapping procedure

Journal of Statistical Planning and Inference, 139(3), 978–989.

By: F. Zou*, L. Nie*, F. Wright* & P. Sen*

co-author countries: United States of America 🇺🇸
author keywords: GEE; Generalized least squares estimate; Quantitative trait; Weighted least squares estimate; Wilcoxon-Mann-Whitney statistic
Source: Crossref
Added: August 28, 2020

2009 journal article

A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis

Diabetologia, 52(9), 1858–1865.

By: S. Blackman*, S. Hsu*, S. Ritter*, K. Naughton*, F. Wright*, M. Drumm*, M. Knowles*, G. Cutting*

co-author countries: United States of America 🇺🇸
author keywords: Association; CFRD; Corticosteroid; Cystic fibrosis; Diabetes; Genetics; Glucocorticoid; Modifier gene; TCF7L2
Source: Crossref
Added: August 28, 2020

2009 journal article

Erratum: Genomewide association for schizophrenia in the CATIE study: results of stage 1

Molecular Psychiatry, 14(12), 1144–1144.

By: P. Sullivan, D. Lin, J. Tzeng*, E. van den Oord, D. Perkins, T. Stroup, M. Wagner, S. Lee ...

Source: Crossref
Added: February 24, 2020

2009 journal article

Genetic Modifiers of Liver Disease in Cystic Fibrosis

JAMA, 302(10), 1076–1083.

By: J. Bartlett, K. Friedman*, S. Ling*, R. Pace, S. Bell, B. Bourke*, G. Castaldo*, C. Castellani* ...

co-author countries: Argentina 🇦🇷 Australia 🇦🇺 Canada 🇨🇦 Czechia 🇨🇿 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Ireland 🇮🇪 Israel 🇮🇱 Italy 🇮🇹 United States of America 🇺🇸
MeSH headings : Adolescent; Adult; Age Factors; Child; Child, Preschool; Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Female; Glutathione S-Transferase pi / genetics; Humans; Hypertension, Portal / etiology; Hypertension, Portal / genetics; Infant; Liver Cirrhosis / etiology; Liver Cirrhosis / genetics; Liver Diseases / etiology; Liver Diseases / genetics; Logistic Models; Male; Mannose-Binding Lectin / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic; Risk; Transforming Growth Factor beta1 / genetics; Young Adult; alpha 1-Antitrypsin / genetics
Source: Crossref
Added: January 17, 2021

2009 journal article

Replication and narrowing of gene expression quantitative trait loci using inbred mice

Mammalian Genome, 20(7), 437–446.

By: D. Gatti*, A. Harrill*, F. Wright*, D. Threadgill* & I. Rusyn*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Chromosome Mapping / methods; DNA Replication; Female; Gene Expression Profiling / methods; Linkage Disequilibrium; Male; Mice / classification; Mice / genetics; Mice, Inbred Strains; Phylogeny; Quantitative Trait Loci
Source: Crossref
Added: August 28, 2020

2008 journal article

Comment on a Simple and Improved Correction for Population Stratification

The American Journal of Human Genetics, 82(2), 524–526.

co-author countries: United States of America 🇺🇸
MeSH headings : Case-Control Studies; Genetic Markers; Genetics, Population; Genotype; Humans; Polymorphism, Single Nucleotide; Regression Analysis; Research Design
Source: Crossref
Added: August 28, 2020

2008 journal article

Estimating Odds Ratios in Genome Scans: An Approximate Conditional Likelihood Approach

The American Journal of Human Genetics, 82(5), 1064–1074.

By: A. Ghosh*, F. Zou* & F. Wright*

co-author countries: United States of America 🇺🇸
MeSH headings : Genome, Human; Haplotypes; Humans; Likelihood Functions; Models, Genetic; Odds Ratio; Software
Source: Crossref
Added: August 28, 2020

2008 journal article

Estimating Odds Ratios in Genome Scans: An Approximate Conditional Likelihood Approach

The American Journal of Human Genetics, 82(5), 1224.

By: A. Ghosh, F. Zou & F. Wright*

Source: Crossref
Added: August 28, 2020

2008 journal article

Genomewide association for schizophrenia in the CATIE study: results of stage 1

Molecular Psychiatry, 13(6), 570–584.

By: P. Sullivan*, D. Lin*, J. Tzeng n, E. van den Oord*, D. Perkins*, T. Stroup*, M. Wagner*, S. Lee* ...

co-author countries: United States of America 🇺🇸
author keywords: schizophrenia; genomewide association; CATIE
MeSH headings : Antipsychotic Agents / therapeutic use; Case-Control Studies; Computational Biology; DNA / genetics; DNA / isolation & purification; Genetic Markers; Genetic Variation; Genome, Human; Genotype; Humans; National Institute of Mental Health (U.S.); Polymorphism, Single Nucleotide; Schizophrenia / drug therapy; Schizophrenia / genetics; United States
Sources: Crossref, Web Of Science
Added: August 6, 2018

2005 journal article

Genetic Modifiers of Lung Disease in Cystic Fibrosis

New England Journal of Medicine, 353(14), 1443–1453.

By: M. Drumm*, M. Konstan*, M. Schluchter*, A. Handler, R. Pace, F. Zou, M. Zariwala, D. Fargo* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
MeSH headings : Adolescent; Adult; Child; Cystic Fibrosis / classification; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; DNA Replication; Female; Forced Expiratory Volume; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Lung Diseases / classification; Lung Diseases / genetics; Lung Diseases / physiopathology; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Severity of Illness Index; Transforming Growth Factor beta / genetics
Source: Crossref
Added: August 28, 2020

2005 journal article

Group A Streptococcus Transcriptome Dynamics during Growth in Human Blood Reveals Bacterial Adaptive and Survival Strategies

The American Journal of Pathology, 166(2), 455–465.

By: M. Graham*, K. Virtaneva*, S. Porcella*, W. Barry*, B. Gowen*, C. Johnson*, F. Wright*, J. Musser*

co-author countries: United States of America 🇺🇸
MeSH headings : DNA, Complementary / metabolism; Female; Flow Cytometry; Gene Expression Regulation, Bacterial; Humans; Male; Models, Biological; Mutation; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; RNA / metabolism; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Streptococcal Infections / blood; Streptococcal Infections / metabolism; Streptococcus / metabolism; Time Factors
Source: Crossref
Added: August 28, 2020

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