Fred Andrew Wright

A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets

Tsai, H.-H. D., Oware, K. D., Wright, F. A., Chiu, W. A., & Rusyn, I. (2025, March 20). Toxicological Sciences.

An approach to uncover significant direct and mediated relationships in multi-dimensional new approach methods (NAMs) data: A case study of hazard evaluation of petroleum UVCBs

Zhou, Y.-H., Gallins, P. J., Rusyn, I., & Wright, F. A. (2025, May 28). The Science of The Total Environment.

Asian diversity in human immune cells

Kock, K. H., Tan, L. M., Han, K. Y., Ando, Y., Jevapatarakul, D., Chatterjee, A., … Prabhakar, S. (2025, March 19). Cell.

Examining risk assessment implications of genetic and dose-dependent dynamics of lead exposure in breastfeeding using the collaborative cross mouse population

Cuomo, D., Song, Z., Nitcher, M., Lynch, R., Barba, E., Feinberg, A. P., … Threadgill, D. W. (2025, January 30). Toxicological Sciences.

Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits

Currin, K. W., Perrin, H. J., Pandey, G. K., Alkhawaja, A. A., Vadlamudi, S., Musser, A. E., … Mohlke, K. L. (2025, May 20). Genome Research.

HAP-SAMPLE2: data-based resampling for association studies with admixture

Sun, G., Ting, B. W., Wright, F. A., & Zhou, Y.-H. (2025, June 1). (J. Kelso, Ed.). Bioinformatics.

Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model

Song, Z., Tryndyak, V. P., Willett, R. A., Pogribny, I. P., Rusyn, I., & Wright, F. A. (2025, August 8). Toxicological Sciences.

Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice

Tryndyak, V. P., Willett, R. A., Song, Z., Dreval, K., Hanks, J. M. H., Avigan, M. I., … Pogribny, I. P. (2025, June 15). Toxicology and Applied Pharmacology.

Strain and Sex Variability in Liver, Kidney and Lung Levels of DNA Adducts EB-GII and bis-N7G-BD Following Inhalation Exposure to 1,3-Butadiene in Collaborative Cross Mice

Moran, E., Goodman, S., Wright, F. A., Evans, R., Tretyakova, N. Y., & Rusyn, I. (2025, October 3). Toxics.

Zebrafish Cyp1b1 knockout alters eye and brain metabolomic profiles, affecting ocular and neurobehavioral function

Perone, D. M., Annalora, A. J., Goldstone, J. V., Dickey, A. N., Salanga, M. C., Francolini, R. D., … Garcia-Jaramillo, M. (2025, January 29). Toxicology and Applied Pharmacology.

Characterizing PFAS hazards and risks: a human population-based in vitro cardiotoxicity assessment strategy

Ford, L. C., Lin, H.-C., Zhou, Y.-H., Wright, F. A., Gombar, V. K., Sedykh, A., … Rusyn, I. (2024, September 2). Human Genomics, Vol. 18.

Control of false discoveries in grouped hypothesis testing for eQTL data

Rudra, P., Zhou, Y.-H., Nobel, A., & Wright, F. A. (2024, April 11). BMC Bioinformatics, Vol. 25.

Genetic variation in severe cystic fibrosis liver disease is associated with novel mechanisms for disease pathogenesis

Stonebraker, J. R., Pace, R. G., Gallins, P. J., Dang, H., Aksit, M. A., Faino, A. V., … Knowles, M. R. (2024, March 27). Hepatology, Vol. 3.

Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types

Ford, L. C., Lin, H.-C., Tsai, H.-H. D., Zhou, Y.-H., Wright, F. A., Sedykh, A., … Rusyn, I. (2024, February 27). Toxicology, Vol. 503.

Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes

Tsai, H.-H. D., Ford, L. C., Burnett, S. D., Dickey, A. N., Wright, F. A., Chiu, W. A., & Rusyn, I. (2024, July 24). Chemical Research in Toxicology.

Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits

Broadaway, K. A., Brotman, S. M., Rosen, J. D., Currin, K. W., Alkhawaja, A. A., Etheridge, A. S., … Mohlke, K. L. (2024, August 22). The American Journal of Human Genetics, Vol. 111.

OS03-02 To Accept or Not To Accept a Read-Across Adaptation: A Systematic Analysis of 15 Years of Testing Proposal Decisions by the European Chemicals Agency

Roe, H. M., Ball, N., Wright, F. A., Chiu, W. A., & Rusyn, I. (2024, September 1). Toxicology Letters.

Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes

Tsai, H.-H. D., Ford, L. C., Chen, Z., Dickey, A. N., Wright, F. A., & Rusyn, I. (2024, January 1). ALTEX.

Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency

Roe, H., Tsai, H.-H., Ball, N., Wright, F., Chiu, W., & Rusyn, I. (2024, January 1). ALTEX.

Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

Mathisen, G. H., Bearth, A., Jones, L. B., Hoffmann, S., Vist, G. E., Ames, H. M., … Whaley, P. (2024, June 14). Archives of Toxicology.

Two-Stage Machine Learning-Based Approach to Predict Points of Departure for Human Noncancer and Developmental/Reproductive Effects

Kvasnicka, J., Aurisano, N., Borries, K., Lu, E.-H., Fantke, P., Jolliet, O., … Chiu, W. A. (2024, May 2). Environmental Science & Technology.

A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo

Tsai, H.-H. D., House, J. S., Wright, F. A., Chiu, W. A., & Rusyn, I. (2023, April 20). Toxicological Sciences.

Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity

Sakolish, C., Moyer, H. L., Tsai, H.-H. D., Ford, L. C., Dickey, A. N., Wright, F. A., … Rusyn, I. (2023, August 9). Toxicological Sciences.

Application of Ion Mobility Spectrometry–Mass Spectrometry for Compositional Characterization and Fingerprinting of a Library of Diverse Crude Oil Samples

Cordova, A. C., Dodds, J. N., Tsai, H.-H. D., Lloyd, D. T., Roman-Hubers, A. T., Wright, F. A., … Rusyn, I. (2023, August 2). Environmental Toxicology and Chemistry.

Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole-Genome Analysis of 7,840 Patients

Zhou, Y.-H., Gallins, P. J., Pace, R. G., Dang, H., Aksit, M. A., Blue, E. E., … Knowles, M. R. (2023, March 15). American Journal of Respiratory and Critical Care Medicine, Vol. 207, pp. 1324–1333.

Integrative Chemical–Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams

Cordova, A. C., Klaren, W. D., Ford, L. C., Grimm, F. A., Baker, E. S., Zhou, Y.-H., … Rusyn, I. (2023, July 5). Toxics, Vol. 11.

Simultaneous modeling of multivariate heterogeneous responses and heteroskedasticity via a two‐stage composite likelihood

Ting, B. W., Wright, F. A., & Zhou, Y. H. (2023, May 22). Biometrical Journal.

Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations

Rusyn, I., & Wright, F. A. (2023, December 23). Toxicological Sciences.

A Population-Based Human In Vitro Approach to Quantify Inter-Individual Variability in Responses to Chemical Mixtures

Ford, L. C., Jang, S., Chen, Z., Zhou, Y.-H., Gallins, P. J., Wright, F. A., … Rusyn, I. (2022, August 1). Toxics, Vol. 8.

A resource for integrated genomic analysis of the human liver

Zhou, Y.-H., Gallins, P. J., Etheridge, A. S., Jima, D., Scholl, E., Wright, F. A., & Innocenti, F. (2022, September 7). Scientific Reports, Vol. 9.

Characterization of compositional variability in petroleum substances

Roman-Hubers, A. T., Cordova, A. C., Rohde, A. M., Chiu, W. A., McDonald, T. J., Wright, F. A., … Rusyn, I. (2022, February 12). Fuel, Vol. 6.

Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice

Boysen, G., Rusyn, I., Chiu, W. A., & Wright, F. A. (2022, April 22). Regulatory Toxicology and Pharmacology.

Correlation Analysis of Variables From the Atherosclerosis Risk in Communities Study

Mandal, M., Levy, J., Ives, C., Hwang, S., Zhou, Y.-H., Motsinger-Reif, A., … Edwards, S. (2022, July 11). Frontiers in Pharmacology.

Fast Multivariate Probit Estimation via a Two-Stage Composite Likelihood

Ting, B., Wright, F., & Zhou, Y.-H. (2022, February 15). Statistics in Biosciences, Vol. 2.

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, July 4). Epigenetics, Vol. 6.

Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays

House, J. S., Grimm, F. A., Klaren, W. D., Dalzell, A., Kuchi, S., Zhang, S.-D., … Wright, F. A. (2022, January 1). ALTEX, Vol. 39, pp. 388–404.

Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

Harlow, C. E., Gandawijaya, J., Bamford, R. A., Martin, E.-R., Wood, A. R., Most, P. J., … Frayling, T. M. (2022, September 1). The American Journal of Human Genetics.

Leveraging TOPMed imputation server and constructing a cohort-specific imputation reference panel to enhance genotype imputation among cystic fibrosis patients

Sun, Q., Liu, W., Rosen, J. D., Huang, L., Pace, R. G., Dang, H., … Li, Y. (2022, January 11). Human Genetics and Genomics Advances, Vol. 4.

MagicalRsq: Machine-learning-based genotype imputation quality calibration

Sun, Q., Yang, Y., Rosen, J. D., Jiang, M.-Z., Chen, J., Liu, W., … Li, Y. (2022, October 4). The American Journal of Human Genetics, Vol. 109, pp. 1986–1997.

Model systems and organisms for addressing inter- and intra-species variability in risk assessment

Rusyn, I., Chiu, W. A., & Wright, F. A. (2022, May 27). Regulatory Toxicology and Pharmacology.

Pleiotropic modifiers of age-related diabetes and neonatal intestinal obstruction in cystic fibrosis

Aksit, M. A., Ling, H., Pace, R. G., Raraigh, K. S., Onchiri, F., Faino, A. V., … Zhou, Y.-H. (2022, October 1). The American Journal of Human Genetics, Vol. 10.

Spatial and Temporal Analysis of Impacts of Hurricane Florence on Criteria Air Pollutants and Air Toxics in Eastern North Carolina

Bhandari, S., Casillas, G., Aly, N. A., Zhu, R., Newman, G., Wright, F. A., … Chiu, W. A. (2022, February 3). International Journal of Environmental Research and Public Health.

TwinEQTL: ultrafast and powerful association analysis for eQTL and GWAS in twin studies

Xia, K., Shabalin, A. A., Yin, Z., Chung, W., Sullivan, P. F., Wright, F. A., … Zou, F. (2022, June 11). Genetics.

Application of Edible Montmorillonite Clays for the Adsorption and Detoxification of Microcystin

Wang, M., Rivenbark, K., Gong, J., Wright, F. A., & Phillips, T. D. (2021, August 31). ACS Applied Bio Materials, Vol. 9.

Data Processing Workflow to Identify Structurally Related Compounds in Petroleum Substances Using Ion Mobility Spectrometry–Mass Spectrometry

Roman-Hubers, A. T., Cordova, A. C., Aly, N. A., McDonald, T. J., Lloyd, D. T., Wright, F. A., … Rusyn, I. (2021, June 16). Energy & Fuels, Vol. 7.

Environmental impacts of Hurricane Florence flooding in eastern North Carolina: temporal analysis of contaminant distribution and potential human health risks

Aly, N. A., Casillas, G., Luo, Y.-S., McDonald, T. J., Wade, T. L., Zhu, R., … Rusyn, I. (2021, April 24). Journal of Exposure Science & Environmental Epidemiology.

Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene

Erber, L., Goodman, S., Wright, F. A., Chiu, W. A., Tretyakova, N. Y., & Rusyn, I. (2021, November 2). Chemical Research in Toxicology.

Potential Human Health Hazard of Post-Hurricane Harvey Sediments in Galveston Bay and Houston Ship Channel: A Case Study of Using In Vitro Bioactivity Data to Inform Risk Management Decisions

Chen, Z., Jang, S., Kaihatu, J. M., Zhou, Y.-H., Wright, F. A., Chiu, W. A., & Rusyn, I. (2021, December 19). International Journal of Environmental Research and Public Health, Vol. 12.

Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-Derived cardiomyocytes

Luo, Y.-S., Chen, Z., Blanchette, A. D., Zhou, Y.-H., Wright, F. A., Baker, E. S., … Rusyn, I. (2021, January 13). Food and Chemical Toxicology, Vol. 149.

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January 1). Environmental Health Perspectives, Vol. 129, pp. 017701–017701-017701–017703.

Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms

Mukherjee, R., Beykal, B., Szafran, A. T., Onel, M., Stossi, F., Mancini, M. G., … Pistikopoulos, E. N. (2020, September 24). PLoS Computational Biology.

Grouping of UVCB substances with new approach methodologies (NAMs) data

House, J. S., Grimm, F. A., Klaren, W. D., Dalzell, A., Kuchi, S., Zhang, S.-D., … Rusyn, I. (2020, January 1). ALTEX, Vol. 38, pp. 123–137.

Low‐Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells

House, J. S., Bouzos, E., Fahy, K. M., Francisco, V. M., Lloyd, D. T., Wright, F. A., … Wheeler, K. E. (2020, March 29). Small, Vol. 16.

Questioning Existing Cancer Hazard Evaluation Standards in the Name of Statistics

Rusyn, I., Chiu, W. A., & Wright, F. A. (2020, May 22). Toxicological Sciences.

Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs

Chen, Z. (2020, January 1). ALTEX.

Risk Characterization of Environmental Samples UsingIn VitroBioactivity and Polycyclic Aromatic Hydrocarbon Concentrations Data

Chen, Z., Lloyd, D., Zhou, Y.-H., Chiu, W. A., Wright, F. A., & Rusyn, I. (2020, October 28). Toxicological Sciences.

Systematic Comparisons for Composition Profiles, Taxonomic Levels, and Machine Learning Methods for Microbiome-Based Disease Prediction

Song, K., Wright, F. A., & Zhou, Y.-H. (2020, December 16). Frontiers in Molecular Biosciences, Vol. 7.

The GTEx Consortium atlas of genetic regulatory effects across human tissues

Aguet, F., Anand, S., Ardlie, K. G., Gabriel, S., Getz, G. A., Graubert, A., … Gillard, B. M. (2020, September 10). Science.

A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex‐Biased Phenotypes

Etheridge, A. S., Gallins, P. J., Jima, D., Broadaway, K. A., Ratain, M. J., Schuetz, E., … Innocenti, F. (2019, December 23). Clinical Pharmacology & Therapeutics.

Development of the Texas A&M Superfund Research Program Computational Platform for Data Integration, Visualization, and Analysis

Mukherjee, R., Onel, M., Beykal, B., Szafran, A. T., Stossi, F., Mancini, M. A., … Pistikopoulos, E. N. (2019, January 1). Computer-Aided Chemical Engineering/Computer Aided Chemical Engineering.

Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization

Onel, M., Beykal, B., Ferguson, K., Chiu, W. A., McDonald, T. J., Zhou, L., … Pistikopoulos, E. N. (2019, October 10). PLoS ONE, Vol. 14.

Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse

Lewis, L., Borowa-Mazgaj, B., Conti, A., Chappell, G. A., Luo, Y.-S., Bodnar, W., … Rusyn, I. (2019, April 16). Chemical Research in Toxicology.

Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene

Luo, Y.-S., Cichocki, J. A., Hsieh, N.-H., Lewis, L., Wright, F. A., Threadgill, D. W., … Rusyn, I. (2019, June 1). Environmental Health Perspectives.

A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure

Cell Reports, 23(2), 327–336.

A human population-based organotypic in vitro model for cardiotoxicity screening

Grimm, F. A., Blanchette, A., House, J. S., Ferguson, K., Hsieh, N.-H., Dalaijamts, C., … Rusyn, I. (2018, January 1). ALTEX, Vol. 35, pp. 441–452.

Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity

American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.

HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues

BMC Bioinformatics, 19.

Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers

Grimm, F. A., House, J. S., Wilson, M. R., Sirenko, O., Iwata, Y., Wright, F. A., … Rusyn, I. (2018, November 22). Regulatory Toxicology and Pharmacology, Vol. 101, pp. 91–102.

Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes

House, J. S., Mendez, M., Maguire, R. L., Gonzalez-Nahm, S., Huang, Z., Daniels, J., … Hoyo, C. (2018, September 7). Frontiers in Cell and Developmental Biology, Vol. 6, p. 107.

Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp. nov.

Singleton, D. R., Lee, J., Dickey, A. N., Stroud, A., Scholl, E. H., Wright, F. A., & Aitken, M. D. (2018, June 8). Systematic and Applied Microbiology.