Works (41)

2019 journal article

Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 101, 91–102.

By: F. Grimm, J. House, M. Wilson, O. Sirenko, Y. Iwata, F. Wright, N. Ball, I. Rusyn

Source: Web Of Science
Added: April 22, 2019

2019 journal article

Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse

CHEMICAL RESEARCH IN TOXICOLOGY, 32(5), 887–898.

By: L. Lewis, B. Borowa-Mazgaj, A. Conti, G. Chappell, Y. Luo, W. Bodnar, K. Konganti, F. Wright ...

Source: Web Of Science
Added: June 17, 2019

2019 journal article

Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene

ENVIRONMENTAL HEALTH PERSPECTIVES, 127(6).

By: Y. Luo, J. Cichocki, N. Hsieh, L. Lewis, F. Wright, D. Threadgill, W. Chiu, I. Rusyn

Source: Web Of Science
Added: July 29, 2019

2018 journal article

A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(4), 441–452.

By: F. Grimm, A. Blanchette, J. House, K. Ferguson, N. Hsieh, C. Dalaijamts, A. Wright, B. Anson ...

Source: NC State University Libraries
Added: December 10, 2018

2018 journal article

A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure

Cell Reports, 23(2), 327–336.

By: T. Frayling, R. Beaumont, S. Jones, H. Yaghootkar, M. Tuke, K. Ruth, F. Casanova, B. West ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity

American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.

By: D. Polineni, H. Dang, P. Gallins, L. Jones, R. Pace, J. Stonebraker, L. Commander, J. Krenicky ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

An An empirical Bayes approach for multiple tissue eQTL analysis

Biostatistics (Oxford, England), 19(3), 391–406.

By: G. Li, A. Shabalin, I. Rusyn, F. Wright & A. Nobel

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Computation of ancestry scores with mixed families and unrelated individuals

Biometrics, 74(1), 155–164.

By: Y. Zhou, J. Marron & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Estimation of cis-eQTL effect sizes using a log of linear model

BIOMETRICS, 74(2), 616–625.

By: J. Palowitch, A. Shabalin, Y. Zhou, A. Nobel & F. Wright

Source: NC State University Libraries
Added: October 16, 2018

2018 journal article

HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues

BMC Bioinformatics, 19.

By: G. Li, D. Jima, F. Wright & A. Nobel

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 6.

By: J. House, M. Mendez, R. Maguire, S. Gonzalez-Nahm, Z. Huang, J. Daniels, S. Murphy, B. Fuemmeler, F. Wright, C. Hoyo

Source: NC State University Libraries
Added: January 21, 2019

2018 journal article

Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp nov.

SYSTEMATIC AND APPLIED MICROBIOLOGY, 41(5), 460–472.

By: D. Singleton, J. Lee, A. Dickey, A. Stroud, E. Scholl, F. Wright, M. Aitken

Source: NC State University Libraries
Added: October 16, 2018

2018 journal article

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse

Mammalian Genome, 29(1-2), 168–181.

By: A. Venkatratnam, J. House, K. Konganti, C. McKenney, D. Threadgill, W. Chiu, D. Aylor, F. Wright, I. Rusyn

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models

BMC Bioinformatics, 19.

By: S. Marvel, K. To, F. Grimm, F. Wright, I. Rusyn & D. Reif

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

A Pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics

Frontiers in Genetics, 8.

By: J. House, F. Grimm, D. Jima, Y. Zhou, I. Rusyn & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

A procedure to detect general association based on concentration of ranks

Stat, 6(1), 88–101.

By: P. Rudra, Y. Zhou & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

A tiered, Bayesian approach to estimating population variability for regulatory decision-making

Altex-Alternatives to Animal Experimentation, 34(3), 377–388.

By: W. Chiu, F. Wright & I. Rusyn

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Adrenal-derived stress hormones modulate ozone-induced lung injury and inflammation

Toxicology and Applied Pharmacology, 329, 249–258.

By: A. Henriquez, J. House, D. Miller, S. Snow, A. Fisher, H. Ren, M. Schladweiler, A. Ledbetter, F. Wright, U. Kodavanti

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

An An improved and explicit surrogate variable analysis procedure by coefficient adjustment

Biometrika, 104(2), 303–316.

By: S. Lee, W. Sun, F. Wright & F. Zou

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Conditional eQTL analysis reveals allelic heterogeneity of gene expression

Human Molecular Genetics, 26(8), 1444–1451.

By: R. Jansen, J. Hottenga, M. Nivard, A. Abdellaoui, B. Laport, E. Geus, F. Wright, B. Penninx, D. Boomsma

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Editor's highlight: Collaborative cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism

Toxicological Sciences, 158(1), 48–62.

By: A. Venkatratnam, S. Furuya, O. Kosyk, A. Gold, W. Bodnar, K. Konganti, D. Threadgill, K. Gillespie ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Functional architectures of local and distal regulation of gene expression in multiple human tissues

American Journal of Human Genetics, 100(4), 605–616.

By: X. Liu, H. Finucane, A. Gusev, G. Bhatia, S. Gazal, L. O'Connor, B. Bulik-Sullivan, F. Wright ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Genetic effects on gene expression across human tissues

Nature, 550(7675), 204-.

By: F. Aguet, A. Brown, S. Castel, J. Davis, Y. He, B. Jo, P. Mohammadi, Y. Park ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

A A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

Green Chemistry, 18(16), 4407–4419.

By: F. Grimm, Y. Iwata, O. Sirenko, G. Chappell, F. Wright, D. Reif, J. Braisted, D. Gerhold ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Gene expression in major depressive disorder

Molecular Psychiatry, 21(3), 339–347.

By: R. Jansen, B. Penninx, V. Madar, K. Xia, Y. Milaneschi, J. Hottenga, A. Hammerschlag, A. Beekman ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium

PLoS One, 11(12).

By: X. Tian, K. Patel, J. Ridpath, Y. Chen, Y. Zhou, D. Neo, J. Clement, M. Takata ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Integrative approaches for large-scale transcriptome-wide association studies

Nature Genetics, 48(3), 245–252.

By: A. Gusev, A. Ko, H. Shi, G. Bhatia, W. Chung, B. Penninx, R. Jansen, E. Geus ...

Source: NC State University Libraries
Added: August 6, 2018

2016 conference paper

Poster: risk-based attack surface approximation

In Symposium and Bootcamp on the Science of Security (pp. 121–123).

By: C. Theisen & L. Williams

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

The projack: a resampling approach to correct for ranking bias in high-throughput studies

Biostatistics (Oxford, England), 17(1), 54–64.

By: Y. Zhou & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Consistent testing for recurrent genomic aberrations

Biometrika, 102(4), 783–796.

By: V. Walter, F. Wright & A. Nobel

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Gene expression in transformed lymphocytes reveals variation in endomembrane and HLA pathways modifying cystic fibrosis pulmonary phenotypes

American Journal of Human Genetics, 96(2), 318–328.

By: W. O'Neal, P. Gallins, R. Pace, H. Dang, W. Wolf, L. Jones, X. Guo, Y. Zhou ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Nature Communications, 6.

By: H. Corvol, S. Blackman, P. Boelle, P. Gallins, R. Pace, J. Stonebraker, F. Accurso, A. Clement ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Hypothesis testing at the extremes: Fast and robust association for high-throughput data

Biostatistics (Oxford, England), 16(3), 611–625.

By: Y. Zhou & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

By: J. Rager, S. Tilley, S. Tulenko, L. Smeester, P. Ray, A. Yosim, J. Currier, M. Ishida ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

In vitro screening for population variability in toxicity of pesticide-containing mixtures

Environment International, 85, 147–155.

By: N. Abdo, B. Wetmore, G. Chappell, D. Shea, F. Wright & I. Rusyn

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Population-based in vitro hazard and concentration-response assessment of chemicals: The 1000 genomes high-throughput screening study

Environmental Health Perspectives, 123(5), 458–466.

By: N. Abdo, M. Xia, C. Brown, O. Kosyk, R. Huang, S. Sakamuru, Y. Zhou, J. Jack ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Prediction of human population responses to toxic compounds by a collaborative competition

Nature Biotechnology, 33(9), 933–172.

By: F. Eduati, L. Mangravite, T. Wang, H. Tang, J. Bare, R. Huang, T. Norman, M. Kellen ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

The human transcriptome across tissues and individuals

Science, 348(6235), 660–665.

By: M. Mele, P. Ferreira, F. Reverter, D. DeLuca, J. Monlong, M. Sammeth, T. Young, J. Goldmann ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Convergence of sample eigenvalues, eigenvectors, and principal component scores for ultra-high dimensional data

Biometrika, 101(2), 484–490.

By: S. Lee, F. Zou & F. Wright

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Heritability and genomics of gene expression in peripheral blood

Nature Genetics, 46(5), 430–437.

By: F. Wright, P. Sullivan, A. Brooks, F. Zou, W. Sun, K. Xia, V. Madar, R. Jansen ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse

Environmental Health Perspectives, 122(5), 456–463.

By: W. Chiu, J. Campbell, H. Clewell, Y. Zhou, F. Wright, K. Guyton, I. Rusyn

Source: NC State University Libraries
Added: August 6, 2018