Works (68)

Updated: March 2nd, 2026 21:07

2026 journal article

Establishment of a sedation threshold score for orthopedic radiographs in dogs and evaluation of inter-rater reliability and accuracy of video-based assessment

The Canadian Veterinary Journal, Feb;67(2):180. https://www.canadianveterinarians.net/journals-and-classified-ads/the-canadian-veterinary-journal/table-of-contents-and-abstracts/

By: C. J

Contributors: D. Pang, C. Leriquier, D. Gagnon, J. Vibora & M. Freire

Source: ORCID
Added: February 1, 2026

2025 article

Biosynthetic Collagen-Analog Hydrogels Stimulate Endogenous Regrowth of Rabbit Corneas: A Pilot Study

Timmerman, I., Robert, M.-C., Vergneau-Grosset, C., Juette, T., Benito, J., Garbin, M., … Vanore, M. (2025, August 21). Veterinary Sciences.

topics (OpenAlex): Corneal Surgery and Treatments; Corneal surgery and disorders; Ocular Surface and Contact Lens
Source: ORCID
Added: October 10, 2025

2025 article

Pharmacokinetics of bupivacaine after bilateral maxillary and caudal inferior alveolar nerve blocks using two injection volumes in adult cats

Steagall, P. V., Monteiro, B. P., Garbin, M., Benito, J., Ruel, H. L. M., & Cagnardi, P. (2025, December 2). Journal of Feline Medicine and Surgery.

By: P. Steagall*, B. Monteiro*, M. Garbin*, J. Benito*, H. Ruel* & P. Cagnardi*

MeSH headings : Animals; Bupivacaine / pharmacokinetics; Bupivacaine / administration & dosage; Bupivacaine / blood; Cats; Anesthetics, Local / pharmacokinetics; Anesthetics, Local / administration & dosage; Anesthetics, Local / blood; Nerve Block / veterinary; Nerve Block / methods; Male; Female; Mandibular Nerve; Prospective Studies; Maxillary Nerve; Area Under Curve
topics (OpenAlex):
Source: ORCID
Added: December 2, 2025

2025 article

Ultrasound-guided transversus abdominis plane block in rabbits: an anatomical and computed tomography study

Martin, R., Benito, J., Finck, C., Moreira, J., & Garbin, M. (2025, January 1). Veterinary Anaesthesia and Analgesia.

By: R. Martin, J. Benito*, C. Finck, J. Moreira & M. Garbin

topics (OpenAlex): Anesthesia and Pain Management; Veterinary Pharmacology and Anesthesia; Anesthesia and Sedative Agents
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2. Zero Hunger (OpenAlex)
Source: ORCID
Added: October 10, 2025

2025 journal article

Use of a novel subcutaneous injection site in the region of acupuncture point GV20 for premedicating cats before general anesthesia

Can Vet J . 2025 May;66(5):537-545., May;66(5):537-545. https://pubmed.ncbi.nlm.nih.gov/37559443/

By: C. J

Contributors: B. Solash, J. Cheema, M. Freire, J. Benito & D. Pang

Source: ORCID
Added: October 10, 2025

2024 journal article

Comparison of sedation with dexmedetomidine administered subcutaneously at 2 different locations on the head in dogs.

The Canadian Veterinary Journal = La Revue Veterinaire Canadienne. https://pubmed.ncbi.nlm.nih.gov/37559443/

By: M. Llido, C. Leriquier, T. Juette, J. Benito & M. Freire

Source: ORCID
Added: October 10, 2025

2024 article

Evaluation of three doses of oral trazodone and their impact on handling, activity, and physiological parameters in rabbits: a prospective, blinded, randomized cross-over study

WATANABE, R., GIBERT, A., BENITO, J., GARBIN, M., KWONG, G. P. S., DESMARCHELIER, M., & BENEDETTI, I.-C. C. R. U. Z. (2024, January 1). Journal of Veterinary Medical Science.

MeSH headings : Animals; Rabbits; Female; Trazodone / administration & dosage; Trazodone / pharmacology; Cross-Over Studies; Administration, Oral; Prospective Studies; Dose-Response Relationship, Drug; Heart Rate / drug effects; Behavior, Animal / drug effects; Motor Activity / drug effects; Blood Gas Analysis / veterinary; Selective Serotonin Reuptake Inhibitors / administration & dosage; Selective Serotonin Reuptake Inhibitors / pharmacology
topics (OpenAlex): Rabbits: Nutrition, Reproduction, Health; Veterinary Pharmacology and Anesthesia; Diet and metabolism studies
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: October 10, 2025

2023 article

Atipamezole via GV20-acupoint or intramuscularly reversed dexmedetomidine sedation in laboratory rabbits

Benito, J., Garbin, M., Gibert, A., & Benedetti, I.-C. C. (2023, November 1). Veterinary Anaesthesia and Analgesia.

By: J. Benito*, M. Garbin*, A. Gibert* & I. Benedetti*

topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Sedative Agents; Anesthesia and Pain Management
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: October 10, 2025

2023 journal article

Comparison of sedation with dexmedetomidine/atipamezole administered subcutaneously at GV20 acupuncture point with usual routes of administration in dogs presented for orthopaedic radiographs

Journal of Small Animal Practice, 64(12), 759–768.

By: C. Leriquier*, M. Freire*, M. Llido*, G. Beauchamp*, X. Montasell*, D. Gagnon*, J. Benito*

MeSH headings : Animals; Dogs; Acupuncture Points; Dexmedetomidine / administration & dosage; Dexmedetomidine / adverse effects; Double-Blind Method; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / adverse effects; Orthopedics; Prospective Studies; Dog Diseases / diagnostic imaging; Injections, Subcutaneous / methods
topics (OpenAlex): Anesthesia and Sedative Agents; Veterinary Pharmacology and Anesthesia; Acupuncture Treatment Research Studies
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: October 10, 2025

2023 article

Morphological Evaluation of Transscleral Laser Retinopexy in Rabbits: Comparison of Optical Coherence Tomography and Histologic Examinations

Vanore, M., Juette, T., Benito, J., & Benoit-Biancamano, M.-O. (2023, August 23). Veterinary Sciences, Vol. 10, p. 535.

topics (OpenAlex): Retinal and Macular Surgery; Optical Coherence Tomography Applications; Glaucoma and retinal disorders
Source: ORCID
Added: October 10, 2025

2022 journal article

A disposable, canister-free negative-pressure wound therapy device proves feasible, but of inferior efficacy to conventional therapies for treating cutaneous wounds in dogs

American Journal of Veterinary Research, 83(10).

By: M. Freire*, C. Job*, I. Hassanpour*, J. Benito*, D. Pang*, M. Paquet*, C. Theoret*

MeSH headings : Animals; Bandages / veterinary; Dogs; Female; Granulation Tissue; Negative-Pressure Wound Therapy / veterinary; Skin; Wound Healing
topics (OpenAlex): Wound Healing and Treatments; Surgical Sutures and Adhesives; Surgical site infection prevention
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: October 10, 2025

2022 article

A randomized, prospective, masked clinical trial comparing an opioid-free vs. opioid-sparing anesthetic technique in adult cats undergoing ovariohysterectomy

Rufiange, M., Ruel, H. L. M., Monteiro, B. P., Watanabe, R., Benedetti, I.-C. C., Benito, J., & Steagall, P. V. M. (2022, November 11). Frontiers in Veterinary Science, Vol. 9.

topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Pain Management; Veterinary Equine Medical Research
Source: ORCID
Added: October 10, 2025

2022 article

Long-term supplementation with an undenatured type-II collagen (UC-II"&#".ord($0).";""&#".ord($0).";") formulation in dogs with degenerative joint disease: exploratory study

Cabezas, M., Benito, J., Ortega, A., & Pedraza, E. (2022, January 1). Open Veterinary Journal, Vol. 12, p. 91.

By: M. Cabezas, J. Benito*, A. Ortega & E. Pedraza

MeSH headings : Animals; Collagen Type II; Dietary Supplements; Dog Diseases / drug therapy; Dogs; Joint Diseases / veterinary; Prospective Studies
topics (OpenAlex): Veterinary Orthopedics and Neurology; Tendon Structure and Treatment; Osteoarthritis Treatment and Mechanisms
Source: ORCID
Added: October 10, 2025

2022 article

Pharmacokinetics of Bupivacaine Following Administration by an Ultrasound-Guided Transversus Abdominis Plane Block in Cats Undergoing Ovariohysterectomy

Garbin, M., Benito, J., Ruel, H. L. M., Watanabe, R., Monteiro, B. P., Cagnardi, P., & Steagall, P. V. (2022, July 25). Pharmaceutics, Vol. 14, p. 1548.

topics (OpenAlex): Anesthesia and Pain Management; Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research; Anesthesia and Sedative Agents
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2021 article

Extraction of aberrant tusk and mandibular osteomyelitis treatment in a pot-bellied pig (Sus scrofa domesticus)

Savard, C., Dumais, Y., Pouillevet, H., Marcoux, J., Finck, C., Finck, M., … Vergneau-Grosset, C. (2021, June 19). Journal of Exotic Pet Medicine, Vol. 39, pp. 24–31.

By: C. Savard, Y. Dumais, H. Pouillevet, J. Marcoux*, C. Finck*, M. Finck, J. Benito*, M. Rainville, C. Vergneau-Grosset*

topics (OpenAlex): Rabies epidemiology and control; Orthopedic Infections and Treatments; Microbial infections and disease research
Source: ORCID
Added: October 10, 2025

2021 article

Recording and manipulation of vagus nerve electrical activity in chronically instrumented unanesthetized near term fetal sheep

Castel, A., Burns, P. M., Benito, J., Liu, H. L., Kuthiala, S., Durosier, L. D., … Frasch, M. G. (2021, June 15). Journal of Neuroscience Methods, Vol. 360, p. 109257.

By: A. Castel*, P. Burns*, J. Benito*, H. Liu*, S. Kuthiala*, L. Durosier*, Y. Frank*, M. Cao* ...

MeSH headings : Animals; Disease Models, Animal; Female; Fetus; Nervous System Physiological Phenomena; Pregnancy; Sheep; Vagus Nerve; Vagus Nerve Stimulation
topics (OpenAlex): Vagus Nerve Stimulation Research; Neuroscience of respiration and sleep; Infant Health and Development
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2020 article

Clinical applicability of the Feline Grimace Scale: real-time versus image scoring and the influence of sedation and surgery

Evangelista, M. C., Benito, J., Monteiro, B. P., Watanabe, R., Doodnaught, G. M., Pang, D. S. J., & Steagall, P. V. (2020, April 14). PeerJ.

topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Human-Animal Interaction Studies; Veterinary Equine Medical Research
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2019 article

Analgesic Efficacy of Bupivacaine or Bupivacaine-Dexmedetomidine After Intraperitoneal Administration in Cats: A Randomized, Blinded, Clinical Trial

Benito, J., Evangelista, M. C., Doodnaught, G. M., Watanabe, R., Beauchamp, G., Monteiro, B. P., & Steagall, P. (2019, September 13). Frontiers in Veterinary Science, Vol. 6.

topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Pain Management; Veterinary Equine Medical Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2019 article

Analgesic efficacy of bupivacaine in comparison with bupivacaine-dexmedetomidine after intraperitoneal administration in cats: a randomized clinical trial

Benito, J., Evangelista, M., Doodnaught, G., Watanabe, R., Beauchamp, G., Monteiro, B., & Steagall, P. (2019, November 1). Veterinary Anaesthesia and Analgesia.

topics (OpenAlex): Anesthesia and Pain Management; Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2019 article

Intraperitoneal and incisional analgesia in small animals: simple, cost‐effective techniques

Steagall, P. V. M., Benito, J., Monteiro, B., Lascelles, D., Kronen, P. W., Murrell, J. C., … Yamashita, K. (2019, November 18). Journal of Small Animal Practice, Vol. 61, pp. 19–23.

MeSH headings : Analgesia / veterinary; Animals; Cost-Benefit Analysis; Pain / veterinary; Pain Management / veterinary
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research; Anesthesia and Pain Management
TL;DR: The World Small Animal Veterinary Association Global Pain Council (WSAVA-GPC) has recently published its first "capsule review" by Monteiro et al, where the use of intraperitoneal and incisional analgesia in small animal practice is discussed. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 2, 2019

2018 journal article

Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain

The Veterinary Journal, 243, 42–47.

By: M. Ashwell n, M. Freire n, A. O’Nan n, J. Benito n, J. Hash n, R. McCulloch*, B. Lascelles n

author keywords: Cat; Degenerative joint disease; Neurobiological signature; Osteoarthritis; Pain
MeSH headings : Animals; Cat Diseases / genetics; Cats; Female; Ganglia, Spinal / metabolism; Ganglia, Spinal / physiopathology; Gene Expression; Gene Expression Profiling; Lumbosacral Region / physiopathology; Male; Osteoarthritis, Spine / veterinary; Pain / genetics; Pain / veterinary; Spinal Cord Dorsal Horn / metabolism; Spinal Cord Dorsal Horn / physiopathology
topics (OpenAlex): Veterinary Orthopedics and Neurology; Veterinary Equine Medical Research; Osteoarthritis Treatment and Mechanisms
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: February 11, 2019

2018 journal article

Efficacy and pharmacokinetics of bupivacaine with epinephrine or dexmedetomidine after intraperitoneal administration in cats undergoing ovariohysterectomy.

Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire. https://europepmc.org/articles/PMC5914079

By: J. Benito, B. Monteiro, F. Beaudry & P. Steagall

Source: ORCID
Added: October 10, 2025

2018 article

Sculpting the Sculptors: Methods for Studying the Fetal Cholinergic Signaling on Systems and Cellular Scales

Frasch, M. G., Burns, P., Benito, J., Cortes, M., Cao, M., Fecteau, G., & Desrochers, A. (2018, January 1). Methods in Molecular Biology, pp. 341–352.

MeSH headings : Acetylcholine / metabolism; Animals; Cholinergic Agents / pharmacology; Female; Fetus / cytology; Fetus / drug effects; Fetus / metabolism; Microglia / cytology; Microglia / drug effects; Microglia / metabolism; Psychoneuroimmunology / methods; Sheep; Signal Transduction; Vagus Nerve / cytology; Vagus Nerve / drug effects; Vagus Nerve / metabolism; Vagus Nerve Stimulation / methods; alpha7 Nicotinic Acetylcholine Receptor / metabolism
topics (OpenAlex): Vagus Nerve Stimulation Research; Neuroendocrine regulation and behavior; Infant Health and Development
Source: ORCID
Added: October 10, 2025

2017 journal article

Agreement among undergraduate and graduate veterinary students and veterinary anesthesiologists on pain assessment in cats and dogs: A preliminary study.

The Canadian Veterinary Journal = La Revue Veterinaire Canadienne. https://europepmc.org/articles/PMC5508929

By: G. Doodnaught, J. Benito, B. Monteiro, G. Beauchamp, S. Grasso & P. Steagall

Source: ORCID
Added: October 10, 2025

2017 article

Analgesic effects of gabapentin and buprenorphine in cats undergoing ovariohysterectomy using two pain-scoring systems: a randomized clinical trial

Steagall, P. V., Benito, J., Monteiro, B. P., Doodnaught, G. M., Beauchamp, G., & Evangelista, M. C. (2017, September 18). Journal of Feline Medicine and Surgery, Vol. 20, pp. 741–748.

MeSH headings : Analgesics, Opioid / administration & dosage; Animals; Buprenorphine / administration & dosage; Cat Diseases / drug therapy; Cat Diseases / surgery; Cats; Gabapentin / administration & dosage; Hysterectomy / adverse effects; Hysterectomy / veterinary; Ovariectomy / adverse effects; Ovariectomy / veterinary; Pain Management / veterinary; Pain Measurement / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Random Allocation
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Pain Management; Opioid Use Disorder Treatment
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2017 journal article

Evaluation of interobserver agreement for postoperative pain and sedation assessment in cats

Journal of the American Veterinary Medical Association, 251(5), 544–551.

By: J. Benito*, B. Monteiro, G. Beauchamp, B. Lascelles* & P. Steagall

MeSH headings : Analgesia; Animals; Bupivacaine; Buprenorphine; Cats / surgery; Female; Hysterectomy / veterinary; Observer Variation; Ovariectomy / veterinary; Pain Measurement / veterinary; Pain, Postoperative / diagnosis; Pathologists / psychology; Reproducibility of Results
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research; Pediatric Pain Management Techniques
TL;DR: Interobserver differences in assessing pain can lead to different conclusions regarding treatment effectiveness, and interobserver agreements for pain scores were good, and that for sedation scores was fair. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref
Added: June 30, 2019

2017 article

Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats

Doodnaught, G. M., Monteiro, B. P., Benito, J., Edge, D., Beaudry, F., Pelligand, L., & Steagall, P. (2017, April 26). (F. Staffieri, Ed.). PLoS ONE, Vol. 12, p. e0176443.

Ed(s): F. Staffieri

MeSH headings : Administration, Buccal; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Analgesics, Opioid / pharmacology; Animals; Biological Availability; Buprenorphine / analogs & derivatives; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Buprenorphine / pharmacology; Cats; Cross-Over Studies; Disease Models, Animal; Female; Half-Life; Injections, Intravenous; Injections, Subcutaneous; Male; Models, Biological; Pain / prevention & control; Pain Threshold / drug effects; Placebo Effect; Prospective Studies; Time Factors
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Opioid Use Disorder Treatment; Animal testing and alternatives
Source: ORCID
Added: October 10, 2025

2017 article

Postoperative analgesia between non-pregnant healthy cats versus pregnant or cats with upper respiratory tract disease

Benito, J., & Steagall, P. (2017, January 1). Veterinary Anaesthesia and Analgesia.

By: J. Benito* & P. Steagall*

topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Veterinary Orthopedics and Neurology; Pediatric Pain Management Techniques
Source: ORCID
Added: October 10, 2025

2016 article

Effects of dexmedetomidine administered at acupuncture point GV20 compared to intramuscular route in dogs

Pons, A., Canfrán, S., Benito, J., Cediel‐Algovia, R., & Segura, I. A. G. (2016, November 14). Journal of Small Animal Practice, Vol. 58, pp. 23–28.

MeSH headings : Acupuncture Points; Animals; Cross-Over Studies; Dexmedetomidine / administration & dosage; Dexmedetomidine / therapeutic use; Dogs; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / therapeutic use; Injections, Intramuscular / veterinary; Male; Single-Blind Method
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Sedative Agents; Pain Mechanisms and Treatments
Source: ORCID
Added: October 10, 2025

2016 article

Metamizole (dipyrone) effects on sevoflurane requirements and postoperative hyperalgesia in rats

Ruiz-Pérez, D., Benito, J., Largo, C., Polo, G., Canfrán, S., & Segura, I. A. G. (2016, September 30). Laboratory Animals, Vol. 51, pp. 365–375.

MeSH headings : Animals; Dipyrone / pharmacology; Hyperalgesia / drug therapy; Hyperalgesia / veterinary; Male; Methyl Ethers / pharmacokinetics; Nociception / drug effects; Pain Threshold / drug effects; Prospective Studies; Pulmonary Alveoli / metabolism; Random Allocation; Rats; Rats, Wistar; Sevoflurane
topics (OpenAlex): Pain Mechanisms and Treatments; Neuropeptides and Animal Physiology; Anesthesia and Sedative Agents
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2016 article

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Benito, J., Monteiro, B. P., Beaudry, F., Lavoie, A.-M., Lascelles, B. D. X., & Steagall, P. V. (2016, May 26). American Journal of Veterinary Research, Vol. 77, pp. 641–645.

By: J. Benito*, B. Monteiro, F. Beaudry, A. Lavoie, B. Lascelles* & P. Steagall

MeSH headings : Anesthesia / veterinary; Anesthetics, Local / administration & dosage; Anesthetics, Local / blood; Anesthetics, Local / pharmacokinetics; Anesthetics, Local / pharmacology; Animals; Biological Availability; Bupivacaine / administration & dosage; Bupivacaine / blood; Bupivacaine / pharmacokinetics; Bupivacaine / pharmacology; Buprenorphine / administration & dosage; Cats / blood; Female; Half-Life; Hysterectomy / veterinary; Isoflurane; Meloxicam; Ovariectomy / veterinary; Propofol; Thiazines; Thiazoles
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Pain Management; Veterinary Equine Medical Research
TL;DR: Intraperitoneal administration of bupivacaine resulted in concentrations that did not cause observable toxicosis and studies to investigate analgesic effects for this technique in cats are warranted. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 article

The Effects of the Toll-Like Receptor 4 Antagonist, Ibudilast, on Sevoflurane’s Minimum Alveolar Concentration and the Delayed Remifentanil-Induced Increase in the Minimum Alveolar Concentration in Rats

Ruiz-Pérez, D., Benito, J., Polo, G., Largo, C., Aguado, D., Sanz, L., & Segura, I. A. G. (2016, February 9). Anesthesia & Analgesia, Vol. 122, pp. 1370–1376.

MeSH headings : Administration, Inhalation; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Analgesics, Opioid / toxicity; Anesthetics, Inhalation / administration & dosage; Anesthetics, Inhalation / pharmacology; Animals; Behavior, Animal / drug effects; Drug Interactions; Drug Tolerance; Injections, Intraperitoneal; Injections, Intravenous; Male; Methyl Ethers / administration & dosage; Methyl Ethers / pharmacology; Naloxone / pharmacology; Narcotic Antagonists / pharmacology; Pain Threshold / drug effects; Piperidines / administration & dosage; Piperidines / pharmacology; Piperidines / toxicity; Pyridines / administration & dosage; Pyridines / pharmacology; Rats, Wistar; Remifentanil; Sevoflurane; Time Factors; Toll-Like Receptor 4 / antagonists & inhibitors
topics (OpenAlex): Anesthesia and Sedative Agents; Anesthesia and Neurotoxicity Research; Neuropeptides and Animal Physiology
Source: ORCID
Added: October 10, 2025

2015 article

Analgesic efficacy of intraperitoneal administration of bupivacaine in cats

Benito, J., Monteiro, B., Lavoie, A.-M., Beauchamp, G., Lascelles, B. D. X., & Steagall, P. V. (2015, October 15). Journal of Feline Medicine and Surgery, Vol. 18, pp. 906–912.

By: J. Benito*, B. Monteiro*, A. Lavoie*, G. Beauchamp*, B. Lascelles n & P. Steagall*

MeSH headings : Analgesics, Opioid / administration & dosage; Anesthesia / veterinary; Anesthetics, Local / administration & dosage; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Buprenorphine / administration & dosage; Cats / physiology; Cats / surgery; Female; Hysterectomy / veterinary; Injections, Intraperitoneal / veterinary; Meloxicam; Ovariectomy / veterinary; Pain Measurement / veterinary; Pain, Postoperative / prevention & control; Pain, Postoperative / veterinary; Prospective Studies; Thiazines / administration & dosage; Thiazoles / administration & dosage; Treatment Outcome
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Pain Management; Veterinary Equine Medical Research
TL;DR: Based on rescue analgesia, IP administration of bupivacaine provides analgesia in cats after OVH and the DIVAS, MCPS and MNT were significantly different when compared with baseline values at different time points; however, data were not significantly different among groups. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Assessment of tandem mass spectrometry and high‐resolution mass spectrometry for the analysis of bupivacaine in plasma

Gaudette, F., Benito, J., Steagall, P., & Beaudry, F. (2015, May 12). Biomedical Chromatography, Vol. 29, pp. 1724–1730.

MeSH headings : Anesthetics, Local / blood; Animals; Bupivacaine / blood; Calibration; Cats; Chromatography, High Pressure Liquid / methods; Female; Limit of Detection; Reproducibility of Results; Tandem Mass Spectrometry / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
Source: ORCID
Added: October 10, 2025

2015 article

Tramadol-induced hyperalgesia and its prevention by ketamine in rats

Abreu, M., Aguado, D., Benito, J., García-Fernández, J., & Segura, I. A. G. (2015, August 21). European Journal of Anaesthesiology, Vol. 32, pp. 735–741.

MeSH headings : Analgesics / pharmacology; Analgesics, Opioid / adverse effects; Anesthetics, Inhalation / pharmacokinetics; Animals; Hyperalgesia / chemically induced; Hyperalgesia / prevention & control; Ketamine / pharmacology; Male; Methyl Ethers / pharmacokinetics; Pulmonary Alveoli / metabolism; Random Allocation; Rats; Rats, Wistar; Sevoflurane; Time Factors; Tramadol / adverse effects
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Pain Mechanisms and Treatments; Anesthesia and Sedative Agents
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2014 article

Amitriptyline, minocycline and maropitant reduce the sevoflurane minimum alveolar concentration and potentiate remifentanil but do not prevent acute opioid tolerance and hyperalgesia in the rat

Aguado, D., Abreu, M., Benito, J., García-Fernández, J., & Segura, I. A. G. (2014, May 21). European Journal of Anaesthesiology, Vol. 32, pp. 248–254.

MeSH headings : Amitriptyline / pharmacology; Analgesics, Opioid / toxicity; Anesthetics, Inhalation / administration & dosage; Anesthetics, Inhalation / pharmacokinetics; Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Hyperalgesia / chemically induced; Hyperalgesia / physiopathology; Hyperalgesia / psychology; Male; Methyl Ethers / administration & dosage; Methyl Ethers / pharmacokinetics; Minocycline / pharmacology; Nociception / drug effects; Pain Threshold / drug effects; Piperidines / toxicity; Pulmonary Alveoli / metabolism; Quinuclidines / pharmacology; Random Allocation; Rats, Wistar; Remifentanil; Sevoflurane
topics (OpenAlex): Pain Mechanisms and Treatments; Neuropeptides and Animal Physiology; Neuroscience and Neuropharmacology Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2014 article

COMPARISON OF ISOFLURANE AND ALFAXALONE (ALFAXAN) FOR THE INDUCTION OF ANESTHESIA IN FLAMINGOS (PHOENICOPTERUS ROSEUS) UNDERGOING ORTHOPEDIC SURGERY

Villaverde-Morcillo, S., Benito, J., García-Sánchez, R., Martín-Jurado, O., & Segura, I. A. G. (2014, June 1). Journal of Zoo and Wildlife Medicine, Vol. 45, pp. 361–366.

By: S. Villaverde-Morcillo, J. Benito*, R. García-Sánchez, O. Martín-Jurado & I. Segura

MeSH headings : Anesthesia Recovery Period; Anesthesia, General / veterinary; Anesthetics, Inhalation / pharmacology; Animals; Birds / injuries; Birds / physiology; Birds / surgery; Female; Fracture Fixation / veterinary; Fractures, Bone / surgery; Fractures, Bone / veterinary; Isoflurane / pharmacology; Male; Pregnanediones / pharmacology
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Turtle Biology and Conservation; Veterinary Equine Medical Research
Sources: ORCID, NC State University Libraries
Added: October 10, 2025

2014 journal article

Comparison of isoflurane and alfaxalone (Alfaxan) for the induction of anesthesia in flamingos (Phoenicopterus roseus) undergoing orthopedic surgery

Journal of Zoo and Wildlife Medicine, 45(2), 361–366.

By: S. Villaverde-Morcillo, J. Benito, R. Garcia-Sanchez, O. Martin-Jurado & I. Segura

Source: NC State University Libraries
Added: August 6, 2018

2014 article

Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat

Abreu, M., Aguado, D., Benito, J., García-Fernández, J., & Segura, I. A. G. (2014, December 8). European Journal of Anaesthesiology, Vol. 32, pp. 232–241.

MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / toxicity; Anesthetics, Inhalation / administration & dosage; Anesthetics, Inhalation / pharmacokinetics; Animals; Behavior, Animal / drug effects; Buprenorphine / toxicity; Hyperalgesia / chemically induced; Hyperalgesia / physiopathology; Hyperalgesia / prevention & control; Hyperalgesia / psychology; Ketamine / pharmacology; Male; Methadone / toxicity; Methyl Ethers / administration & dosage; Methyl Ethers / pharmacokinetics; Morphine / toxicity; Nociception / drug effects; Pain Threshold / drug effects; Piperidines / toxicity; Pulmonary Alveoli / metabolism; Random Allocation; Rats, Wistar; Remifentanil; Sevoflurane
topics (OpenAlex): Anesthesia and Sedative Agents; Pain Mechanisms and Treatments; Anesthesia and Pain Management
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2013 article

Effects of Naloxone on Opioid-induced Hyperalgesia and Tolerance to Remifentanil under Sevoflurane Anesthesia in Rats

Aguado, D., Abreu, M., Benito, J., Garcia-Fernandez, J., & Segura, I. A. G. (2013, February 13). Anesthesiology, Vol. 118, pp. 1160–1169.

By: D. Aguado, M. Abreu*, J. Benito n, J. Garcia-Fernandez* & I. Segura*

MeSH headings : Analgesics, Opioid / pharmacology; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Behavior, Animal / drug effects; Drug Tolerance; Hyperalgesia / chemically induced; Male; Methyl Ethers; Naloxone / pharmacology; Narcotic Antagonists / pharmacology; Pain Threshold / drug effects; Physical Stimulation; Piperidines / pharmacology; Pulmonary Alveoli / metabolism; Rats; Rats, Wistar; Remifentanil; Sevoflurane
topics (OpenAlex): Pain Mechanisms and Treatments; Veterinary Pharmacology and Anesthesia; Neuropeptides and Animal Physiology
Source: ORCID
Added: October 10, 2025

2013 journal article

Evaluation of the clinical use of tepoxalin and meloxicam in cats

Journal of Feline Medicine and Surgery, 15(8), 678–690.

By: A. Charlton n, J. Benito n, W. Simpson*, M. Freire n & B. Lascelles n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / drug therapy; Cats; Female; Male; Meloxicam; Pyrazoles / adverse effects; Pyrazoles / therapeutic use; Retrospective Studies; Thiazines / adverse effects; Thiazines / therapeutic use; Thiazoles / adverse effects; Thiazoles / therapeutic use
topics (OpenAlex): Inflammatory mediators and NSAID effects; Adrenal Hormones and Disorders; Veterinary Equine Medical Research
TL;DR: Tepoxalin and meloxicam are well tolerated in the clinical setting at the doses prescribed in this study, and several statistically significant changes for serum biochemistry and hematology parameters were within normal limits. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 article

Feasibility and repeatability of thermal quantitative sensory testing in normal dogs and dogs with hind limb osteoarthritis-associated pain

Williams, M. D., Kirkpatrick, A. E., Griffith, E., Benito, J., Hash, J., & Lascelles, B. D. X. (2013, November 11). The Veterinary Journal, Vol. 199, pp. 63–67.

By: M. Williams n, A. Kirkpatrick n, E. Griffith n, J. Benito n, J. Hash n & B. Lascelles n

author keywords: Canine; Quantitative sensory testing; Osteoarthritis; Thermal threshold
MeSH headings : Animals; Differential Threshold / physiology; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Hindlimb / pathology; Hot Temperature / adverse effects; Neurologic Examination; Osteoarthritis / diagnosis; Osteoarthritis / pathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / pathology; Pain / veterinary; Pain Threshold
topics (OpenAlex): Veterinary Orthopedics and Neurology; Veterinary Equine Medical Research; Infrared Thermography in Medicine
TL;DR: In conclusion, thermal thresholds can be measured in client owned dogs with no prior training and are repeatable from week to week. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Feline Musculoskeletal Pain Index: Responsiveness and Testing of Criterion Validity

Benito, J., Hansen, B., DePuy, V., Davidson, G. S., Thomson, A., Simpson, W., … Lascelles, B. D. X. (2013, April 3). Journal of Veterinary Internal Medicine, Vol. 27, pp. 474–482.

By: J. Benito n, B. Hansen n, V. DePuy*, G. Davidson n, A. Thomson n, W. Simpson*, S. Roe n, E. Hardie n, B. Lascelles n

author keywords: DJD; Chronic pain; Feline; FMPI; Meloxicam
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Female; Male; Meloxicam; Musculoskeletal Pain / diagnosis; Musculoskeletal Pain / drug therapy; Musculoskeletal Pain / veterinary; Surveys and Questionnaires; Thiazines / therapeutic use; Thiazoles / therapeutic use
topics (OpenAlex): Veterinary Orthopedics and Neurology; Human-Animal Interaction Studies; Veterinary Equine Medical Research
TL;DR: The data suggest that further work is indicated to understand factors affecting activity in cats to optimize inclusion criteria, and neither responsiveness nor criterion validity were detected by the inclusion criteria for cases in this study. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Histological and molecular characterisation of feline humeral condylar osteoarthritis

Ryan, J. M., Lascelles, B. D. X., Benito, J., Hash, J., Smith, S. H., Bennett, D., … Clements, D. N. (2013, June 4). BMC Veterinary Research, Vol. 9.

By: J. Ryan*, B. Lascelles n, J. Benito n, J. Hash n, S. Smith*, D. Bennett*, D. Argyle*, D. Clements*

author keywords: Osteoarthritis; Feline; Humeral condyle; Gene expression; Histomorphometry
MeSH headings : Animals; Cartilage, Articular / metabolism; Cartilage, Articular / pathology; Cat Diseases / metabolism; Cat Diseases / pathology; Cats; Chondrocytes / metabolism; Chondrocytes / pathology; Female; Humerus / metabolism; Humerus / pathology; Male; Osteoarthritis / metabolism; Osteoarthritis / pathology; Osteoarthritis / veterinary; Osteocytes / pathology; Real-Time Polymerase Chain Reaction / veterinary; Transcriptome
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Veterinary Orthopedics and Neurology; Veterinary Equine Medical Research
TL;DR: Histopathological changes identified in OA of the feline humeral condyle appear to primarily affect the medial aspect of the joint, and suggest that SCB is involved in the OA process in cats. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Reliability and discriminatory testing of a client-based metrology instrument, feline musculoskeletal pain index (FMPI) for the evaluation of degenerative joint disease-associated pain in cats

The Veterinary Journal, 196(3), 368–373.

By: J. Benito n, V. DePuy, E. Hardie n, H. Zamprogno n, A. Thomson n, W. Simpson*, S. Roe n, B. Hansen n, B. Lascelles n

author keywords: Assessment; Degenerative joint disease; Feline; Pain
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / pathology; Cats; Osteoarthritis / pathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / pathology; Pain / veterinary; Pain Measurement / methods; Pain Measurement / veterinary
topics (OpenAlex): Veterinary Orthopedics and Neurology; Orthopedic Surgery and Rehabilitation; Shoulder Injury and Treatment
TL;DR: An initial evaluation of the FMPI suggests that this instrument is worthy of continued investigation. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 19, 2019

2012 journal article

Non-invasive monitoring of adrenocortical activity in European badgers (Meles meles) and effects of sample collection and storage on faecal cortisol metabolite concentrations

Animal Biology, 62(4), 419–432.

By: I. Barja, G. Escribano-Avila, C. Lara-Romero, E. Virgos, J. Benito & E. Rafart

Source: NC State University Libraries
Added: August 6, 2018

2012 article

Non-invasive monitoring of adrenocortical activity in European badgers (Meles meles) and effects of sample collection and storage on faecal cortisol metabolite concentrations

Barja, I., Escribano-Ávila, G., Lara-Romero, C., Virgós, E., Benito, J., & Rafart, E. (2012, January 1). Animal Biology, Vol. 62, pp. 419–432.

topics (OpenAlex): Animal Behavior and Welfare Studies; Effects of Environmental Stressors on Livestock; Human-Animal Interaction Studies
Source: ORCID
Added: October 10, 2025

2012 article

Owner-assessed indices of quality of life in cats and the relationship to the presence of degenerative joint disease

Benito, J., Gruen, M. E., Thomson, A., Simpson, W., & Lascelles, B. D. X. (2012, October 1). Journal of Feline Medicine and Surgery, Vol. 14, pp. 863–870.

By: J. Benito n, M. Gruen n, A. Thomson n, W. Simpson* & B. Lascelles n

MeSH headings : Animals; Cat Diseases / prevention & control; Cat Diseases / psychology; Cats; Female; Human-Animal Bond; Humans; Joint Diseases / psychology; Joint Diseases / veterinary; Joint Instability / psychology; Joint Instability / veterinary; Male; Quality of Life; Running; Surveys and Questionnaires; Walking
topics (OpenAlex): Veterinary Orthopedics and Neurology; Human-Animal Interaction Studies; Veterinary Oncology Research
TL;DR: Regardless of DJD status, 40% of items listed by owners involved mobility, while 60% were ‘inactive’ items, rejecting the hypothesis that items contributing to QoL in cats are predominantly items requiring mobility. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Reduction of the sevoflurane minimum alveolar concentration induced by methadone, tramadol, butorphanol and morphine in rats

Abreu, M., Aguado, D., Benito, J., & Segura, I. A. G. (2012, July 1). Laboratory Animals, Vol. 46, pp. 200–206.

By: M. Abreu*, D. Aguado*, J. Benito n & I. Segura*

MeSH headings : Administration, Inhalation; Analgesics, Opioid / administration & dosage; Anesthetics, Inhalation / administration & dosage; Animals; Drug Combinations; Drug Interactions; Male; Methyl Ethers / administration & dosage; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Rats; Rats, Sprague-Dawley; Sevoflurane
topics (OpenAlex): Anesthesia and Sedative Agents; Veterinary Pharmacology and Anesthesia; Anesthesia and Pain Management
Source: ORCID
Added: October 10, 2025

2012 article

The Effects of Gabapentin on Acute Opioid Tolerance to Remifentanil Under Sevoflurane Anesthesia in Rats

Aguado, D., Abreu, M., Benito, J., Garcia-Fernandez, J., & Segura, I. A. G. (2012, May 1). Anesthesia & Analgesia, Vol. 115, pp. 40–45.

MeSH headings : Adjuvants, Anesthesia / administration & dosage; Adjuvants, Anesthesia / toxicity; Amines / administration & dosage; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / toxicity; Anesthesia, General; Anesthetics, Inhalation / administration & dosage; Animals; Cyclohexanecarboxylic Acids / administration & dosage; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Gabapentin; Hyperalgesia / chemically induced; Hyperalgesia / physiopathology; Hyperalgesia / prevention & control; Male; Methyl Ethers / administration & dosage; Pain Threshold / drug effects; Piperidines / administration & dosage; Piperidines / toxicity; Rats; Rats, Wistar; Remifentanil; Sevoflurane; Time Factors; gamma-Aminobutyric Acid / administration & dosage
topics (OpenAlex): Anesthesia and Sedative Agents; Anesthesia and Pain Management; Veterinary Pharmacology and Anesthesia
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2011 article

Ketamine and Remifentanil Interactions on the Sevoflurane Minimum Alveolar Concentration and Acute Opioid Tolerance in the Rat

Aguado, D., Abreu, M., Benito, J., García-Fernández, J., & Segura, I. A. G. (2011, July 22). Anesthesia & Analgesia, Vol. 113, pp. 505–512.

MeSH headings : Analgesics / pharmacology; Analgesics, Opioid / pharmacology; Analysis of Variance; Anesthetics, Inhalation / pharmacology; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Ketamine / pharmacology; Male; Methyl Ethers / pharmacology; Naloxone / pharmacology; Narcotic Antagonists / pharmacology; Pain Measurement; Pain Threshold / drug effects; Piperidines / pharmacology; Rats; Rats, Wistar; Remifentanil; Sevoflurane
topics (OpenAlex): Anesthesia and Sedative Agents; Anesthesia and Neurotoxicity Research; Veterinary Pharmacology and Anesthesia
Sources: ORCID, NC State University Libraries
Added: October 10, 2025

2011 article

Liver impairment after portacaval shunt in the rat: The loss of protective role of mast cells?

Aller, M.-A., Martinez, V., Corcuera, M.-T., Benito, J., Traver, E., Gómez-Aguado, F., … Arias, J. (2011, September 20). Acta Histochemica, Vol. 114, pp. 301–310.

By: M. Aller*, V. Martinez*, M. Corcuera, J. Benito*, E. Traver*, F. Gómez-Aguado, P. Vergara*, J. Arias*

MeSH headings : Alanine Transaminase / analysis; Animals; Aspartate Aminotransferases / analysis; Cell Count; Chronic Disease; Chymases / analysis; Connective Tissue Cells / metabolism; Connective Tissue Cells / pathology; Disease Models, Animal; Hepatic Insufficiency / etiology; Hepatic Insufficiency / pathology; Hepatic Insufficiency / physiopathology; Intestinal Mucosa; Liver / metabolism; Liver / pathology; Liver / physiopathology; Liver Cirrhosis / etiology; Liver Cirrhosis / pathology; Liver Cirrhosis / physiopathology; Lymph Nodes / metabolism; Lymph Nodes / pathology; Male; Mast Cells / pathology; Mesentery / metabolism; Mesentery / pathology; Mucous Membrane / metabolism; Mucous Membrane / pathology; Necrosis / etiology; Necrosis / pathology; Necrosis / physiopathology; Portacaval Shunt, Surgical / adverse effects; Rats; Rats, Wistar
topics (OpenAlex): Mast cells and histamine; Renin-Angiotensin System Studies; Circadian rhythm and melatonin
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

2011 journal article

Reduction of the minimum alveolar concentration of isoflurane in dogs using a constant rate of infusion of lidocaine-ketamine in combination with either morphine or fentanyl

Veterinary Journal, 189(1), 63–66.

By: D. Aguado, J. Benito & I. Segura

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

ketamine and remifentanil interactions on the sevoflurane minimum alveolar concentration and acute opioid tolerance in the rat

Anesthesia and Analgesia, 113(3), 505–512.

By: D. Aguado, M. Abreu, J. Benito, J. Garcia-Fernandez & I. Segura

Source: NC State University Libraries
Added: August 6, 2018

2010 article

Reduction of the minimum alveolar concentration of isoflurane in dogs using a constant rate of infusion of lidocaine–ketamine in combination with either morphine or fentanyl

Aguado, D., Benito, J., & Segura, I. A. G. (2010, July 2). The Veterinary Journal, Vol. 189, pp. 63–66.

By: D. Aguado*, J. Benito n & I. Segura*

MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Anesthetics / administration & dosage; Anesthetics / pharmacology; Animals; Dogs; Drug Combinations; Female; Fentanyl / administration & dosage; Fentanyl / pharmacology; Hysterectomy / veterinary; Isoflurane / administration & dosage; Isoflurane / pharmacokinetics; Ketamine / administration & dosage; Ketamine / pharmacology; Lidocaine / administration & dosage; Lidocaine / pharmacology; Morphine / administration & dosage; Morphine / pharmacology; Ovariectomy / veterinary; Pulmonary Alveoli / metabolism
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Sedative Agents; Anesthesia and Pain Management
Sources: ORCID, NC State University Libraries
Added: October 10, 2025

2010 article

Remifentanil and cyclooxygenase inhibitors interactions in the minimum alveolar concentration of sevoflurane in the rat

Benito, J., Aguado, D., Abreu, M. B., García-Fernández, J., & Segura, I. A. G. (2010, September 22). British Journal of Anaesthesia, Vol. 105, pp. 810–817.

MeSH headings : Acetaminophen / pharmacology; Analgesics, Opioid / pharmacology; Anesthetics, Inhalation / administration & dosage; Anesthetics, Inhalation / pharmacokinetics; Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Drug Interactions; Drug Synergism; Drug Tolerance; Male; Methyl Ethers / administration & dosage; Methyl Ethers / pharmacokinetics; Piperidines / pharmacology; Pulmonary Alveoli / metabolism; Rats; Rats, Wistar; Remifentanil; Sevoflurane
topics (OpenAlex): Inflammatory mediators and NSAID effects; Anesthesia and Sedative Agents; Cancer, Stress, Anesthesia, and Immune Response
Sources: ORCID, NC State University Libraries
Added: October 10, 2025

2010 journal article

Remifentanil and cyclooxygenase inhibitors interactions in the minimum alveolar concentration of sevoflurane in the rat

British Journal of Anaesthesia, 105(6), 810–817.

By: J. Benito, D. Aguado, M. Abreu, J. Garcia-Fernandez & I. Segura

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Determination of the minimum alveolar concentration for halothane, isoflurane and sevoflurane in the gerbil

Segura, I. A. G., Víbora, J. B., & Criado, A. (2009, April 23). Laboratory Animals, Vol. 43, pp. 239–242.

By: I. Segura*, J. Víbora* & A. Criado*

MeSH headings : Anesthetics, Inhalation / pharmacokinetics; Animals; Blood Gas Analysis; Blood Pressure / drug effects; Blood Pressure / physiology; Body Temperature / drug effects; Body Temperature / physiology; Female; Gerbillinae; Halothane / pharmacokinetics; Heart Rate / drug effects; Heart Rate / physiology; Intubation, Intratracheal; Isoflurane / pharmacokinetics; Methyl Ethers / pharmacokinetics; Pulmonary Alveoli / metabolism; Respiration / drug effects; Sevoflurane
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Sedative Agents; Thermal Regulation in Medicine
Source: ORCID
Added: October 10, 2025

2009 journal article

Opioid Tolerance Blunts the Reduction in the Sevoflurane Minimum Alveolar Concentration Produced by Remifentanil in the Rat

Anesthesiology, 110(5), 1133–1138.

By: I. Segura, J. Vibora & D. Aguado

MeSH headings : Administration, Inhalation; Analgesics, Opioid / administration & dosage; Animals; Drug Interactions / physiology; Drug Tolerance / physiology; Male; Methyl Ethers / administration & dosage; Methyl Ethers / metabolism; Piperidines / administration & dosage; Piperidines / metabolism; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Rats; Rats, Wistar; Remifentanil; Sevoflurane
Source: ORCID
Added: October 10, 2025

2008 article

Autotrasplante renal laparoscópico experimental como modelo de aprendizaje de técnica laparoscópica

Bazán, A. A., Betancourt, F., Murillo, S., Víbora, J. B., Ledo, J. C., & Peña Barthel, J. (2008, January 1). Actas Urológicas Españolas, Vol. 32, pp. 160–165.

By: A. Bazán*, F. Betancourt*, S. Murillo*, J. Víbora*, J. Ledo* & J. Peña Barthel*

MeSH headings : Animals; Female; Kidney Transplantation / education; Kidney Transplantation / methods; Laparoscopy; Models, Animal; Swine
topics (OpenAlex): Organ Donation and Transplantation; Ureteral procedures and complications; Abdominal Surgery and Complications
Source: ORCID
Added: October 10, 2025

2008 journal article

Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat

Veterinary Anaesthesia and Analgesia, 35(6), 501–510.

By: J. Benito-de-la-Víbora*, B. Lascelles n, P. García-Fernández*, M. Freire* & I. Gómez de Segura*

MeSH headings : Analgesics / therapeutic use; Animals; Cats / surgery; Female; Hysterectomy / adverse effects; Hysterectomy / veterinary; Meloxicam; Ovariectomy / adverse effects; Ovariectomy / veterinary; Pain Measurement / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Thiazines / therapeutic use; Thiazoles / therapeutic use; ortho-Aminobenzoates / therapeutic use
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research; Anesthesia and Pain Management
TL;DR: Tolfenamic acid and meloxicam administered preoperatively provided a similar analgesic effect in the postoperative period lasting 24 hours, suggesting mechanical thresholds may be a better way of evaluating postoperative analgesia provided by nonsteroidal anti-inflammatory drugs in cats. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2008 article

In Situ Kidney Insonation With Microbubble Contrast Agents Does Not Cause Renal Tissue Damage in a Porcine Model

Jiménez, C., Gracia, R., Aguilera, A., Alonso, S., Cirugeda, A., Benito, J., … Selgas, R. (2008, November 1). Journal of Ultrasound in Medicine, Vol. 27, pp. 1607–1615.

By: C. Jiménez, R. Gracia*, A. Aguilera, S. Alonso, A. Cirugeda*, J. Benito*, R. Regojo*, R. Aguilar ...

MeSH headings : Animals; Contrast Media; Humans; Kidney / cytology; Kidney / diagnostic imaging; Kidney / injuries; Microbubbles; Models, Animal; Risk Assessment / methods; Sonication; Sulfur Hexafluoride / adverse effects; Swine; Ultrasonography
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Renal and Vascular Pathologies; MRI in cancer diagnosis
Source: ORCID
Added: October 10, 2025

2004 article

Autotransplante renal laparoscópico experimental

bazán, A. A., ledo, J. C., barthel, J. D., Murillo, S., & víbora, J. B. (2004, January 1). Actas Urológicas Españolas, Vol. 28, pp. 27–31.

By: A. bazán*, J. ledo*, J. barthel*, S. Murillo* & J. víbora*

MeSH headings : Animals; Female; Kidney Transplantation / methods; Laparoscopy; Swine
topics (OpenAlex): Surgical Simulation and Training; Organ Donation and Transplantation; Minimally Invasive Surgical Techniques
Source: ORCID
Added: October 10, 2025

2002 article

Electrophysiologic cardiac effects of the new local anesthetic IQB‐9302 and of bupivacaine in the anesthetised dog

Segura, I. A. G. D., Vazquez, I., Benito, J., Galiano, A., Miguel, E. D., & Moreno‐Planas. (2002, June 6). Acta Anaesthesiologica Scandinavica.

By: I. Segura*, I. Vazquez*, J. Benito*, A. Galiano*, E. Miguel* & Moreno‐Planas

MeSH headings : Anesthetics, Inhalation / therapeutic use; Anesthetics, Local / therapeutic use; Animals; Bupivacaine / therapeutic use; Cardiovascular System / drug effects; Catheterization; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Isoflurane / therapeutic use; Piperidines / therapeutic use
topics (OpenAlex): Anesthesia and Pain Management; Cardiac electrophysiology and arrhythmias; Veterinary Pharmacology and Anesthesia
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

1999 article

Lung transplantation from ventilated non-heart-beating donors: Experimental study in a neonatal swine model

Greco, R., Benito, J., Gonzalez, M., Miguel, E. D., & Vazquez, J. (1999, February 1). Journal of Pediatric Surgery, Vol. 34, pp. 360–366.

By: R. Greco*, J. Benito*, M. Gonzalez*, E. Miguel* & J. Vazquez*

MeSH headings : Analysis of Variance; Animals; Heart Arrest, Induced; Ischemia / physiopathology; Lung / blood supply; Lung / physiopathology; Lung Compliance; Lung Transplantation; Organ Preservation / methods; Random Allocation; Respiration, Artificial; Swine; Tissue Donors; Transplantation, Homologous
topics (OpenAlex): Transplantation: Methods and Outcomes; Organ Transplantation Techniques and Outcomes; Mechanical Circulatory Support Devices
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

1999 journal article

[Hemodynamics and oxygenation in experimental lung lobe transplantation]

Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica.

By: R. Greco, J. Benito, M. González, M. de & J. Vázquez

Source: ORCID
Added: October 10, 2025

1998 article

Reduced-Size Lung Transplantation from Adult to Neonatal Swine*

Greco, R., Benito, J., Cordovilla, G., Sanz, E., Gonzalez, M., Miguel, E. D., … Galliani, C. (1998, October 1). European Journal of Pediatric Surgery, Vol. 8, pp. 268–273.

By: R. Greco, J. Benito*, G. Cordovilla, E. Sanz, M. Gonzalez, E. Miguel, J. Tovar, C. Galliani*

MeSH headings : Animals; Animals, Newborn; Disease Models, Animal; Feasibility Studies; Hemodynamics; Lung Transplantation / methods; Lung Transplantation / physiology; Pneumonectomy; Respiratory Mechanics; Swine
topics (OpenAlex): Transplantation: Methods and Outcomes; Organ Transplantation Techniques and Outcomes; Xenotransplantation and immune response
Source: ORCID
Added: October 10, 2025

1998 article

Warm ischemic time tolerance after ventilated non-heart-beating lung donation in piglets1

Greco, R., Cordovilla, G., Sanz, E., Benito, J., Criado, A., Gonzalez, M., & Miguel, E. D. (1998, September 1). European Journal of Cardio-Thoracic Surgery, Vol. 14, pp. 319–325.

By: R. Greco*, G. Cordovilla*, E. Sanz*, J. Benito*, A. Criado*, M. Gonzalez*, E. Miguel*

MeSH headings : Animals; Heart Arrest, Induced; Ischemia / physiopathology; Lung / blood supply; Lung / physiopathology; Lung Compliance; Lung Transplantation; Organ Preservation / methods; Random Allocation; Respiration, Artificial; Swine; Time Factors; Tissue Donors; Transplantation, Homologous
topics (OpenAlex): Transplantation: Methods and Outcomes; Organ Transplantation Techniques and Outcomes; Organ Donation and Transplantation
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 10, 2025

Employment

Updated: January 8th, 2026 13:03

2025 - present

Clinical Assistant Professor of Anesthesia & Analgesia North Carolina State University - College of Veterinary Medicine Raleigh, North Carolina, US
Clinical Assistant Professor Molecular Biomedical Sciences

2019 - 2025

Centre hospitalier universitaire vétérinaire (CHUV). Faculté de médecine vétérinaire (FMV). Université de Montréal (UdeM) Saint Hyacinthe, Quebec, CA
Full-Time Clinical Instructor in Anesthesiology (clinicien d'enseignement) Clinical Sciences

2017 - 2019

Centre hospitalier universitaire vétérinaire (CHUV). Faculté de médecine vétérinaire (FMV). Université de Montréal (UdeM) Saint Hyacinthe, Quebec, CA
Part-time Clinical Instructor in Anesthesiology (clinicien d'enseignement) Clinical Sciences

2013 - 2014

Spanish National Center of Cardiovascular Research (CNIC). Madrid, Madrid, ES
Charles River Clinical Veterinarian. Veterinary Head of Animal Facility Comparative Medicine

2007 - 2008

La Paz University Hospital Madrid, Madrid, ES
Clinical Laboratory Animal Veterinarian. Veterinary Responsible. (Locum).) Experimental Surgical Unit

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