Works (10)
Updated: July 30th, 2023 21:14
2021 journal article
A conditional female lethal system for genetic suppression of the global fruit crop pest <scp><i>Drosophila suzukii
Pest Management Science, 77(11), 4915–4922.
author keywords: Drosophila suzukii; spotted wing Drosophila; sterile insect technique; fsRIDL; tet-OFF; alternate splicing
MeSH headings : Animals; Drosophila / genetics; Fruit; Housing, Animal; Rubus; Suppression, Genetic
TL;DR:
It is shown that repeated releases of an excess of transgenic males can suppress D. suzukii populations in laboratory cage trials and suggests that the transgenic strain could provide an effective approach for control of this invasive pest of soft-skinned fruits.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: July 19, 2021
2019 journal article
Specific Gene Disruption in the Major Livestock Pests<i>Cochliomyia hominivorax</i>and<i>Lucilia cuprina</i>Using CRISPR/Cas9
G3 Genes|Genomes|Genetics, 9(9), 3045–3055.
author keywords: Functional genomics; reverse genetics; myiasis; New World Screwworm fly; Australian Sheep Blowfly; gene drive; CRISPR; Cas9; brown body; yellow; transformer
MeSH headings : Animals; Animals, Genetically Modified; CRISPR-Cas Systems; Diptera / embryology; Diptera / genetics; Embryo, Nonmammalian; Female; Insect Proteins / genetics; Male; Mutation; Pest Control / methods; RNA, Guide, Kinetoplastida; Sex Determination Processes
TL;DR:
The CRISPR protocol described here is a significant improvement on the existing toolkit of molecular methods in calliphorids and suggests that Cas9-based systems targeting Chtra and Lctra could be an effective means for controlling natural populations of these important pests.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 23, 2019
2016 journal article
A transgenic male-only strain of the New World screwworm for an improved control program using the sterile insect technique
BMC Biology, 14.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
CRISPR/Cas9-mediated mutagenesis of the white and Sex lethal loci in the invasive pest, Drosophila suzukii
Biochemical and Biophysical Research Communications, 469(4), 911–916.
author keywords: Drosophila suzukii; CRISPR; Cas9; white; Sex-lethal
MeSH headings : ATP-Binding Cassette Transporters / genetics; Animals; CRISPR-Cas Systems / genetics; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Drosophila / classification; Drosophila / genetics; Drosophila Proteins / genetics; Eye Color / genetics; Eye Proteins / genetics; Female; Male; Mutagenesis, Site-Directed / methods; Quantitative Trait Loci / genetics; RNA-Binding Proteins / genetics; Sex Characteristics
TL;DR:
The D. suzukii Sxl gene could be an excellent target for a Cas9-mediated gene drive to suppress populations of this highly destructive pest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Towards next generation maggot debridement therapy: transgenic Lucilia sericata larvae that produce and secrete a human growth factor
BMC Biotechnology, 16(1).
author keywords: Maggot debridement therapy (MDT); Platelet-derived growth factor (PDGF); Excretions/secretions (ES); Growth factor treatment; Diabetic foot ulcer; Tetracycline transactivator; Lucilia sericata; Wound healing
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2014 journal article
Functional characterization of calliphorid cell death genes and cellularization gene promoters for controlling gene expression and cell viability in early embryos
Insect Molecular Biology, 24(1), 58–70.
author keywords: genetic sexing; transgenic; cellularization gene; sterile insect technique
MeSH headings : Amino Acid Sequence; Animals; Animals, Genetically Modified; Base Sequence; Cell Death / genetics; Cell Survival; Diptera / embryology; Diptera / genetics; Diptera / growth & development; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Embryo, Nonmammalian; Female; Gene Expression Regulation; Genes, Insect; Genes, Lethal; Male; Molecular Sequence Data; Pest Control, Biological / methods; Promoter Regions, Genetic; Sex Ratio
TL;DR:
The isolated gene promoters and pro‐apoptotic genes could potentially be used to build transgenic embryonic sexing strains of calliphorid livestock pests.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2014 journal article
Transgenic sexing system for genetic control of the Australian sheep blow fly Lucilia cuprina
Insect Biochemistry and Molecular Biology, 51, 80–88.
author keywords: Sterile insect technique; Transgenic; Lucilia cuprina; Flystrike; Genetic sexing
MeSH headings : Animals; Animals, Genetically Modified; Diptera / genetics; Female; Genes, Insect; Genes, Lethal; Male; Pest Control, Biological / methods; Sex Determination Processes
TL;DR:
Transgenic strains of L. cuprina that carry a dominant tetracycline repressible female lethal genetic system are developed and should be readily transferrable to other major calliphorid livestock pests including the New and Old World screwworm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
Conservation and Sex-Specific Splicing of the transformer Gene in the Calliphorids Cochliomyia hominivorax, Cochliomyia macellaria and Lucilia sericata
PLoS ONE, 8(2), e56303.
Ed(s): G. Tear
MeSH headings : Animals; Base Sequence; Conserved Sequence / genetics; Diptera / genetics; Diptera / growth & development; Diptera / physiology; Female; Genes, Insect / genetics; Male; Molecular Sequence Data; Nucleotide Motifs / genetics; RNA Splicing / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sex Characteristics
TL;DR:
A model for sex specific regulation of tra splicing is proposed that incorporates the conserved features identified in this study and is proposed to facilitate the development of a “male-only” strain for genetic control programs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2012 journal article
A <i>de novo</i> transcriptome assembly of <i>Lucilia sericata</i> (Diptera: Calliphoridae) with predicted alternative splices, single nucleotide polymorphisms and transcript expression estimates
Insect Molecular Biology, 21(2), 205–221.
author keywords: Drosophila; Lucilia; transcriptome; de novo assembly; alternative splice; transposable element
MeSH headings : Alternative Splicing; Animals; Culicidae / genetics; DNA Transposable Elements; Diptera / genetics; Diptera / growth & development; Diptera / metabolism; Drosophila melanogaster / genetics; Female; Gene Expression; Genome, Insect; Male; Molecular Conformation; Multigene Family; Polymorphism, Single Nucleotide; Transcriptome
TL;DR:
The assembly of the transcriptome was carried out in a manner that enabled identification of putative single nucleotide polymorphisms (SNPs) and alternative splices, and that provided expression estimates for various life history stages and for salivary tissue.
(via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2010 journal article
Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila
BMC Molecular Biology, 11(1).
MeSH headings : Acetylation; Amino Acid Sequence; Animals; DNA-Binding Proteins / analysis; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drosophila / enzymology; Drosophila / genetics; Drosophila / metabolism; Drosophila Proteins / analysis; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Female; Genes, Reporter; Genes, X-Linked; Histone Acetyltransferases / analysis; Histone Acetyltransferases / genetics; Histone Acetyltransferases / metabolism; Histones / genetics; Histones / metabolism; Male; Models, Molecular; Molecular Sequence Data; Nuclear Proteins / analysis; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Polytene Chromosomes / chemistry; Recombinant Fusion Proteins / analysis; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Saccharomyces cerevisiae Proteins / analysis; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Sequence Alignment; Sex Factors; Transcription Factors / analysis; Transcription Factors / genetics; Transcription Factors / metabolism; Transcriptional Activation
TL;DR:
Targeting MOF to reporter genes led to transcription enhancement and acetylation of histone H4 at lysine 16 and how association of Gal4-MOF with the MSL or NSL proteins could explain the results is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
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