Fatima Alejos-Gonzalez

Works (4)

Updated: July 5th, 2023 15:59

2017 article

Overexpression of a type‐I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuin B production and artemisinin increase

Ma, D., Li, G., Alejos‐Gonzalez, F., Zhu, Y., Xue, Z., Wang, A., … Xie, D. Y. (2017, April 25). The Plant Journal, Vol. 91, pp. 466–479.

By: D. Ma n, G. Li n, F. Alejos‐Gonzalez n, Y. Zhu n, Z. Xue *, A. Wang *, H. Zhang *, X. Li * ...

Contributors: D. Ma n, G. Li, F. Alejos-Gonzalez n, Y. Zhu n, Z. Xue *, A. Wang *, H. Zhang *, X. Li * ...

MeSH headings : Artemisia annua / enzymology; Artemisia annua / genetics; Artemisia annua / metabolism; Artemisinins / metabolism; Carbon-Carbon Double Bond Isomerases / genetics; Carbon-Carbon Double Bond Isomerases / metabolism; Cytosol / enzymology; Cytosol / metabolism; Hemiterpenes; Plant Proteins / genetics; Plant Proteins / metabolism; Plants, Genetically Modified / enzymology; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism
topics (OpenAlex): Plant biochemistry and biosynthesis; Pharmacological Effects of Natural Compounds; Malaria Research and Control
TL;DR: Evidence is provided that overexpression of AaIPPI1 in the cytosol can lead to metabolic alterations of terpenoid biosynthesis, and it is shown that transgenic plants have the potential to yield high production levels of arteannuin B as a new precursor source for artemisinin. (via Semantic Scholar)
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Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

A Genome-Wide Scenario of Terpene Pathways in Self-pollinated Artemisia annua

Ma, D.-M., Wang, Z., Wang, L., Alejos-Gonzales, F., Sun, M.-A., & Xie, D.-Y. (2015, July 18). Molecular Plant, Vol. 8, pp. 1580–1598.

By: D. Ma n, Z. Wang  n, L. Wang *, F. Alejos-Gonzales n, M. Sun * & D. Xie n 

Contributors: D. Ma n, Z. Wang  n, L. Wang *, F. Alejos-Gonzales n, M. Sun * & D. Xie n 

author keywords: Artemisia annua; artemisinin; terpene; metabolic profiling; pyrosequencing
MeSH headings : Artemisia annua / genetics; Artemisia annua / metabolism; Artemisinins / metabolism; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Genes, Plant; Metabolomics; Pollination / genetics; Self-Fertilization / genetics; Terpenes / metabolism
topics (OpenAlex): Plant biochemistry and biosynthesis; Pharmacological Effects of Natural Compounds; Malaria Research and Control
TL;DR: An integrated approach combining metabolomics, transcriptomics, and gene function analyses was used to characterize gene-to-terpene and terpene pathway scenarios in a self-pollinating variety of Artemisia annua, identifying 47 genes that mapped to the artemisinin, non-amorphadiene sesquiterpene, monoterpenes, triterpenes and mevalonate pathways. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 article

Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants

Alejos-Gonzalez, F., Qu, G., Zhou, L.-L., Saravitz, C. H., Shurtleff, J. L., & Xie, D.-Y. (2011, May 25). Planta, Vol. 234, pp. 685–697.

By: F. Alejos-Gonzalez n, G. Qu n, L. Zhou n, C. Saravitz n, J. Shurtleff n & D. Xie n 

Contributors: F. Alejos-Gonzalez n, G. Qu, L. Zhou n, C. Saravitz n, J. Shurtleff n & D. Xie n 

author keywords: Artemisinin; Artemisia annua; HPLC-MS; Metabolic profiling; Self-pollination; Genetic engineering
MeSH headings : Alkyl and Aryl Transferases / genetics; Antimalarials / isolation & purification; Antimalarials / metabolism; Artemisia annua / anatomy & histology; Artemisia annua / chemistry; Artemisia annua / enzymology; Artemisia annua / physiology; Artemisinins / isolation & purification; Artemisinins / metabolism; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / genetics; Flowers / anatomy & histology; Flowers / chemistry; Flowers / enzymology; Flowers / physiology; Lactones / isolation & purification; Lactones / metabolism; Plant Leaves / anatomy & histology; Plant Leaves / chemistry; Plant Leaves / enzymology; Plant Leaves / physiology; Plant Proteins / genetics; Plants, Medicinal; Pollination / physiology; Seedlings / anatomy & histology; Seedlings / chemistry; Seedlings / enzymology; Seedlings / physiology; Self-Fertilization / physiology; Spectrometry, Mass, Electrospray Ionization; Time Factors
topics (OpenAlex): Plant biochemistry and biosynthesis; Pharmacological Effects of Natural Compounds; Malaria Research and Control
TL;DR: High performance liquid chromatography–mass spectrometry-based metabolic profiling analyses showed that leaves, flowers, and young seedlings of F2 plants produced artemisinin, and RT-PCR analysis showed that progeny of self-pollinated plants expressed the amorpha-4, 11-diene synthase (ADS) and cytochrome P450 monooxygenase 71 AV1 (CYP71AV1) genes, which are involved in art Artemisia annua (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2003 article

Xanosporic acid, an intermediate in bacterial degradation of the fungal phototoxin cercosporin

Mitchell, T. K., Alejos-Gonzalez, F., Gracz, H. S., Danehower, D. A., Daub, M. E., & Chilton, W. S. (2003, March 1). Phytochemistry.

By: T. Mitchell n, F. Alejos-Gonzalez n, H. Gracz n, D. Danehower n, M. Daub n & W. Chilton n

author keywords: Xanthomonas campestris pv. zinniae; bacterial detoxification; perylenequinone; phototoxin; xanosporolactone; xanosporic acid
MeSH headings : Benz(a)Anthracenes / chemistry; Benz(a)Anthracenes / isolation & purification; Benz(a)Anthracenes / metabolism; Biodegradation, Environmental; Carboxylic Acids / chemistry; Carboxylic Acids / metabolism; Circular Dichroism; Fungi / chemistry; Lactones / chemistry; Lactones / isolation & purification; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Perylene / analogs & derivatives; Perylene / chemistry; Perylene / metabolism; Stereoisomerism; Xanthomonas campestris / metabolism
topics (OpenAlex): Photodynamic Therapy Research Studies; Protist diversity and phylogeny; Microbial Natural Products and Biosynthesis
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Source: Web Of Science
Added: August 6, 2018

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