Works (37)

Updated: July 27th, 2023 21:17

2023 article

Age-associated changes in electroretinography measures in companion dogs

Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). DOCUMENTA OPHTHALMOLOGICA, Vol. 6.

co-author countries: United States of America 🇺🇸
author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
Sources: Web Of Science, ORCID
Added: June 19, 2023

2023 article

Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Lynch, A. M. M., Ruterbories, L. K. K., Robertson, J. B. B., Lunn, K. F. F., & Mowat, F. M. M. (2023, April 19). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 4.

By: A. Lynch n, L. Ruterbories n, J. Robertson n, K. Lunn n & F. Mowat n

co-author countries: United States of America 🇺🇸
author keywords: coagulation; fibrinogen; hypercoagulability; SARDS
MeSH headings : Dogs; Animals; Retinal Degeneration / veterinary; Case-Control Studies; Hemostatics; Pilot Projects; Thrombophilia / complications; Thrombophilia / veterinary; Fibrinogen; Antithrombins; Thrombelastography / veterinary; Dog Diseases
Sources: Web Of Science, ORCID
Added: April 20, 2023

2022 journal article

Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

JOURNAL OF ALZHEIMERS DISEASE, 87(3), 1367–1378.

By: G. Fefer n, W. Panek n, M. Khan n, M. Singer n, H. Westermeyer n, F. Mowat n, D. Murdoch*, B. Case n, N. Olby n, M. Gruen n

co-author countries: United States of America 🇺🇸
author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
Sources: Web Of Science, ORCID
Added: June 20, 2022

2021 journal article

A modified silent substitution electroretinography protocol to separate photoreceptor subclass function in lightly sedated dogs

VETERINARY OPHTHALMOLOGY, 24(1), 103–107.

By: E. Wise n, M. Foster n, J. Kremers* & F. Mowat n

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
author keywords: electroretinography; L/M-cone; photoreceptor; rod; S-cone; silent substitution
MeSH headings : Analgesics, Opioid / administration & dosage; Animals; Butorphanol / administration & dosage; Dexmedetomidine / administration & dosage; Dogs / anatomy & histology; Dogs / physiology; Electroretinography / methods; Electroretinography / veterinary; Female; Hypnotics and Sedatives / administration & dosage; Male; Photoreceptor Cells, Vertebrate / classification; Photoreceptor Cells, Vertebrate / physiology
Source: Web Of Science
Added: December 11, 2020

2021 journal article

Canine sudden acquired retinal degeneration syndrome: Owner perceptions on the time to vision loss, treatment outcomes, and prognosis for life

VETERINARY OPHTHALMOLOGY, 24(2), 156–168.

By: D. Washington n, Z. Li*, L. Fox* & F. Mowat n

co-author countries: United States of America 🇺🇸
author keywords: dog; onset time; prognosis; SARDS; treatment
MeSH headings : Animals; Blindness / veterinary; Dog Diseases / physiopathology; Dog Diseases / therapy; Dogs; Prognosis; Retinal Degeneration / physiopathology; Retinal Degeneration / veterinary; Risk Assessment; Surveys and Questionnaires; Time Perception; Treatment Outcome
Source: Web Of Science
Added: January 19, 2021

2021 journal article

Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs

MOLECULAR NEUROBIOLOGY, 58(2), 483–489.

By: W. Panek n, D. Murdoch*, M. Gruen n, F. Mowat n, R. Marek* & N. Olby n

co-author countries: United States of America 🇺🇸

Contributors: W. Panek n, D. Murdoch*, M. Gruen n, F. Mowat n, R. Marek* & N. Olby n

author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; CDS; Amyloid beta 42; Amyloid beta 40
MeSH headings : Aging / blood; Amyloid beta-Peptides / blood; Animals; Cognitive Dysfunction / blood; Dogs / blood; Female; Male; Pets / blood
Sources: Web Of Science, ORCID
Added: October 12, 2020

2021 journal article

Retinal cone photoreceptor distribution in the American black bear (Ursus americanus)

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 304(3), 662–672.

By: J. Heyward n, B. Reynolds*, M. Foster n, K. Archibald n, M. Stoskopf n & F. Mowat n

co-author countries: Australia 🇦🇺 United States of America 🇺🇸
author keywords: black bear; cone; photoreceptor; retina; topography
MeSH headings : Animals; Retina / metabolism; Retinal Cone Photoreceptor Cells / metabolism; Ursidae; Vision, Ocular / physiology
Source: Web Of Science
Added: July 13, 2020

2020 journal article

Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: A case control study

EXPERIMENTAL EYE RESEARCH, 193.

By: F. Mowat n, J. Avelino n, A. Bowyer n, V. Parslow n, H. Westermeyer n, M. Foster n, J. Fogle n, P. Bizikova n

co-author countries: United States of America 🇺🇸
author keywords: SARDS; Dog; Retina; Immune-mediated; IgG; IgM
MeSH headings : Animals; Autoantibodies / immunology; Blotting, Western; Case-Control Studies; Disease Models, Animal; Dogs; Fluorescent Antibody Technique, Indirect / methods; Retina / immunology; Retina / metabolism; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / immunology; Retinal Degeneration / metabolism; Syndrome
Sources: Web Of Science, ORCID
Added: April 20, 2020

2020 journal article

MOLECULAR PREVALENCE OF SELECTED VECTOR-BORNE ORGANISMS IN CAPTIVE RED WOLVES (CANIS RUFUS)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 51(3), 663–667.

By: J. Tyrrell n, B. Qurollo n, F. Mowat n & S. Kennedy-Stoskopf n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Animals, Zoo; Endangered Species; Molecular Epidemiology; Prevalence; United States / epidemiology; Vector Borne Diseases / epidemiology; Vector Borne Diseases / microbiology; Vector Borne Diseases / parasitology; Vector Borne Diseases / veterinary; Wolves
Sources: Web Of Science, ORCID
Added: February 8, 2021

2020 journal article

Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs

MOLECULAR NEUROBIOLOGY, 57(7), 3143–3149.

By: W. Panek n, M. Gruen n, D. Murdoch*, R. Marek*, A. Stachel n, F. Mowat n, K. Saker n, N. Olby n

co-author countries: United States of America 🇺🇸

Contributors: W. Panek n, M. Gruen n, D. Murdoch*, R. Marek*, A. Stachel n, F. Mowat n, K. Saker n, N. Olby n

author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; Amyotrophic lateral sclerosis; Degenerative myelopathy
Sources: Web Of Science, ORCID
Added: July 13, 2020

2019 journal article

Circulating neurohormone imbalances in canine sudden acquired retinal degeneration syndrome and canine pituitary-dependent hypercortisolism

JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(6), 2587–2594.

By: A. Oh n, M. Foster n, K. Lunn n & F. Mowat n

co-author countries: United States of America 🇺🇸
author keywords: dog; dopamine; melatonin; PDH; retina; SARDS; serotonin
MeSH headings : Animals; Case-Control Studies; Dog Diseases / blood; Dog Diseases / metabolism; Dogs; Dopamine / blood; Melatonin / analogs & derivatives; Melatonin / blood; Melatonin / urine; Pituitary ACTH Hypersecretion / blood; Pituitary ACTH Hypersecretion / metabolism; Pituitary ACTH Hypersecretion / veterinary; Prospective Studies; Retinal Degeneration / blood; Retinal Degeneration / metabolism; Retinal Degeneration / veterinary; Serotonin / blood
Sources: Web Of Science, ORCID
Added: November 11, 2019

2019 journal article

Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary‐dependent hyperadrenocorticism in dogs

Veterinary Ophthalmology, 22(6), 842–858.

By: A. Oh n, M. Foster n, J. Williams n, C. Zheng n, H. Ru n, K. Lunn n, F. Mowat n

co-author countries: United States of America 🇺🇸
author keywords: biomarker; dog; hyperadrenocorticism; retina; sudden acquired retinal degeneration syndrome
MeSH headings : Animals; Case-Control Studies; Dog Diseases / diagnosis; Dogs; Electroretinography / veterinary; Female; Male; Pituitary ACTH Hypersecretion / diagnosis; Pituitary ACTH Hypersecretion / veterinary; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / veterinary; Tomography, Optical Coherence / veterinary
Sources: Web Of Science, ORCID, Crossref
Added: December 16, 2019

2019 journal article

In vivo electroretinographic differentiation of rod, short-wavelength and long/medium-wavelength cone responses in dogs using silent substitution stimuli

EXPERIMENTAL EYE RESEARCH, 185.

By: F. Mowat n, E. Wise n, A. Oh n, M. Foster n & J. Kremers*

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
author keywords: dog; Silent substitution; S-Cone; L/M-cone; Rod; Photoreceptor; Electroretinogram; Congenital stationary night blindness
MeSH headings : Animals; Cone Opsins / metabolism; Dark Adaptation; Disease Models, Animal; Dogs; Electroretinography / methods; Eye Diseases, Hereditary / metabolism; Eye Diseases, Hereditary / physiopathology; Female; Genetic Diseases, X-Linked / metabolism; Genetic Diseases, X-Linked / physiopathology; Male; Myopia / metabolism; Myopia / physiopathology; Night Blindness / metabolism; Night Blindness / physiopathology; Retina / metabolism; Retina / physiopathology; Retinal Cone Photoreceptor Cells / physiology; Retinal Rod Photoreceptor Cells / physiology
Sources: Web Of Science, ORCID
Added: September 16, 2019

2019 article

Naturally Occurring Inherited Forms of Retinal Degeneration in Vertebrate Animal Species: A Comparative and Evolutionary Perspective

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY, Vol. 1185, pp. 239–243.

By: F. Mowat*

author keywords: Genetic; Animal model; Naturally occurring; Carnivore; Nondomestic; Retinal phenotype; Retinitis pigmentosa; Leber's congenital amaurosis; Retinal degeneration
Source: Web Of Science
Added: March 10, 2020

2019 journal article

Safety and efficacy of topically applied 0.5% and 1% pirfenidone in a canine model of subconjunctival fibrosis

VETERINARY OPHTHALMOLOGY, 22(4), 502–509.

By: H. Westermeyer n, B. Salmon n, R. Baynes n, J. Yeatts n, A. Khattab n, A. Oh n, F. Mowat n

co-author countries: United States of America 🇺🇸
MeSH headings : Administration, Topical; Animals; Aqueous Humor / drug effects; Conjunctival Diseases / drug therapy; Conjunctival Diseases / pathology; Conjunctival Diseases / veterinary; Disease Models, Animal; Dogs; Drug Implants; Female; Fibrosis / drug therapy; Fibrosis / veterinary; Pyridones / administration & dosage; Pyridones / therapeutic use; Random Allocation
Sources: Web Of Science, ORCID
Added: August 5, 2019

2019 journal article

Use of a Versatile, Inexpensive Ophthalmoscopy Teaching Model in Veterinary Medical Student Education Increases Ophthalmoscopy Proficiency

JOURNAL OF VETERINARY MEDICAL EDUCATION, 46(4), 518–522.

By: H. Westermeyer n, G. Druley*, K. Royal* & F. Mowat n

co-author countries: United States of America 🇺🇸
author keywords: teaching ophthalmoscopy; fundus model; veterinary education
MeSH headings : Animals; Education, Veterinary; Fundus Oculi; Humans; Ophthalmology / education; Ophthalmoscopy; Students, Medical; Teaching
Sources: Web Of Science, ORCID
Added: January 27, 2020

2018 journal article

Clinical findings and outcomes for dogs with uveodermatologic syndrome

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 252(10), 1263–1271.

By: M. Zarfoss, C. Tusler, P. Kass, K. Montgomery, C. Lim, F. Mowat*, S. Thomasy

MeSH headings : Animals; Cohort Studies; Dermatitis, Perioral / complications; Dermatitis, Perioral / diagnosis; Dermatitis, Perioral / epidemiology; Dermatitis, Perioral / veterinary; Dog Diseases / diagnosis; Dog Diseases / epidemiology; Dogs; Female; Glaucoma / complications; Glaucoma / diagnosis; Glaucoma / epidemiology; Glaucoma / veterinary; Male; Pedigree; Records / veterinary; Retrospective Studies; Syndrome; United States / epidemiology; Uveitis / complications; Uveitis / diagnosis; Uveitis / epidemiology; Uveitis / veterinary
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Clinical therapeutic efficacy of mycophenolate mofetil in the treatment of SARDS in dogs-a prospective open-label pilot study

VETERINARY OPHTHALMOLOGY, 21(6), 565–576.

By: W. Young n, A. Oh n, J. Williams n, M. Foster n, W. Miller*, K. Lunn n, F. Mowat n

co-author countries: United States of America 🇺🇸
author keywords: dog; mycophenolate mofetil; retina; sudden acquired retinal degeneration syndrome; treatment; vision
MeSH headings : Animals; Dog Diseases / drug therapy; Dogs; Female; Immunosuppressive Agents / therapeutic use; Male; Mycophenolic Acid / therapeutic use; Pilot Projects; Prospective Studies; Retinal Degeneration / drug therapy; Retinal Degeneration / veterinary; Vision Tests / veterinary
Sources: Web Of Science, ORCID
Added: December 3, 2018

2018 journal article

Ophthalmoscopy skills in primary care: a cross-sectional practitioner survey

VETERINARY RECORD, 182(15), 435-+.

By: F. Mowat n, K. Royal n & H. Westermeyer n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Clinical Competence; Cross-Sectional Studies; Education, Veterinary; Health Care Surveys; Humans; Ophthalmoscopy / statistics & numerical data; Ophthalmoscopy / veterinary; Primary Health Care; Self Efficacy; United States; Veterinarians / psychology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Phenotypic characterization of complete CSNB in the inbred research beagle: how common is CSNB in research and companion dogs?

DOCUMENTA OPHTHALMOLOGICA, 137(2), 87–101.

By: A. Oh n, E. Loew*, M. Foster n, M. Davidson n, R. English*, K. Gervais*, I. Herring*, F. Mowat n

co-author countries: United States of America 🇺🇸
author keywords: Congenital stationary night blindness; Dog; Electroretinography; Complete; Retina
MeSH headings : Adaptation, Ocular / physiology; Animals; Animals, Inbred Strains; Dark Adaptation / physiology; Dogs; Electroretinography; Eye Diseases, Hereditary / physiopathology; Genetic Diseases, X-Linked / physiopathology; Myopia / physiopathology; Night Blindness / physiopathology; Phenotype; Refraction, Ocular / physiology; Retina / physiopathology; Retinal Bipolar Cells / physiology; Retinal Rod Photoreceptor Cells / physiology; Retrospective Studies; Vision, Ocular / physiology
Sources: Web Of Science, ORCID
Added: October 16, 2018

2017 journal article

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(7), 3268–3277.

By: F. Mowat*, K. Gervais*, L. Occelli*, M. Annear*, J. Querubin*, J. Bainbridge*, A. Smith*, R. Ali*, S. Petersen-Jones*

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: canine model; LCA2; RPE65; cone photoreceptors; retinal degeneration; fovea; area centralis
MeSH headings : Analysis of Variance; Animals; Disease Models, Animal; Dogs; Female; Fovea Centralis / pathology; Immunohistochemistry; Male; Retinal Cone Photoreceptor Cells / pathology; Retinal Degeneration / pathology; Retinal Rod Photoreceptor Cells / pathology; Tomography, Optical Coherence; Visual Acuity; cis-trans-Isomerases / deficiency
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Gene Therapy in a Large Animal Model of PDE6A-Retinitis Pigmentosa

FRONTIERS IN NEUROSCIENCE, 11.

By: F. Mowat n, L. Occelli*, J. Bartoe*, K. Gervais*, A. Bruewer*, J. Querubin*, A. Dinculescu*, S. Boye*, W. Hauswirth*, S. Petersen-Jones*

co-author countries: United States of America 🇺🇸
author keywords: retinitis pigmentosa; Pde6 mutation; gene therapy; canine model; adeno-associated virus
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis

EXPERIMENTAL EYE RESEARCH, 147, 148–155.

By: C. Lange*, F. Mowat*, H. Sayed, M. Mehad, L. Duluc*, S. Piper*, U. Luhmann, M. Nandi* ...

co-author countries: Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧
author keywords: DDAH1; DDAH2; ADMA; Nitric oxide; Angiogenesis; Retinal neovascularization
MeSH headings : Amidohydrolases / deficiency; Amidohydrolases / metabolism; Animals; Choroidal Neovascularization / metabolism; Choroidal Neovascularization / physiopathology; Disease Models, Animal; Electroretinography; Immunohistochemistry; Ischemia / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic / metabolism; Nitric Oxide / metabolism; Retinal Neovascularization / metabolism; Retinal Neovascularization / physiopathology; Vascular Endothelial Growth Factor A / metabolism
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Evaluation of the proliferative capacity of canine retinal pigment epithelial cells harvested from different regions of the fundus

Investigative Ophthalmology and Visual Science, 57(12).

By: F. Mowat, J. Hash, P. Mzyk, J. Harned, S. Nagar & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis

New England Journal of Medicine, 372(20), 1887–1897.

By: J. Bainbridge*, M. Mehat*, V. Sundaram*, S. Robbie*, S. Barker*, C. Ripamonti*, A. Georgiadis*, F. Mowat* ...

co-author countries: Belgium 🇧🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Israel 🇮🇱 Mexico 🇲🇽 Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Adolescent; Animals; Child; DNA, Complementary / administration & dosage; Dependovirus; Disease Models, Animal; Disease Progression; Dogs; Genetic Therapy; Genetic Vectors / administration & dosage; Humans; Leber Congenital Amaurosis / genetics; Leber Congenital Amaurosis / therapy; Mutation; Photoreceptor Cells, Vertebrate; Retina / physiology; Vision, Ocular; Young Adult; cis-trans-Isomerases / genetics
Source: Crossref
Added: February 21, 2020

2014 journal article

Assessment of a novel pigmentary chorioretinopathy in the Chinese Crested dog

JSciMed Ophthalmology, 2(2), 1018.

By: K. Narfström, S. Jalomäki, F. Mowat, M. Samardzija, G. Chadieu, T. Bergstrom, R. Bragadottir, C. Grimm

Source: NC State University Libraries
Added: September 8, 2019

2014 journal article

Differential targeting of feline photoreceptors by recombinant adeno-associated viral vectors: implications for preclinical gene therapy trials

Gene Therapy, 21(10), 913–920.

By: A. Minella*, F. Mowat*, K. Willett*, D. Sledge*, J. Bartoe*, J. Bennett*, S. Petersen-Jones*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cats; Dependovirus / genetics; Dependovirus / physiology; Female; Genetic Therapy; Genetic Vectors / administration & dosage; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Injections, Intraocular; Male; Mice; Retinal Cone Photoreceptor Cells / metabolism; Retinal Cone Photoreceptor Cells / virology; Retinal Rod Photoreceptor Cells / metabolism; Retinal Rod Photoreceptor Cells / virology; Transduction, Genetic; Viral Tropism
Source: Crossref
Added: July 20, 2019

2013 journal article

Evaluation of Lateral Spread of Transgene Expression following Subretinal AAV–Mediated Gene Delivery in Dogs

PLoS ONE, 8(4), e60218.

By: A. Bruewer*, F. Mowat*, J. Bartoe*, S. Boye*, W. Hauswirth* & S. Petersen-Jones*

co-author countries: United States of America 🇺🇸

Ed(s): T. Li*

MeSH headings : Actins / genetics; Actins / metabolism; Animals; Capsid Proteins / genetics; Capsid Proteins / metabolism; Chickens; Dependovirus / genetics; Dependovirus / metabolism; Dogs; Electroretinography; Genes, Reporter; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; Injections, Intraocular; Male; Microscopy, Fluorescence; Optic Nerve / ultrastructure; Optic Nerve / virology; Promoter Regions, Genetic; Retina / ultrastructure; Retina / virology; Retinal Detachment / physiopathology; Retinal Detachment / virology; Virus Replication
Source: Crossref
Added: July 20, 2019

2013 journal article

Successful Gene Therapy in Older Rpe65-Deficient Dogs Following Subretinal Injection of an Adeno-Associated Vector Expressing RPE65

Human Gene Therapy, 24(10), 883–893.

By: M. Annear*, F. Mowat*, J. Bartoe*, J. Querubin*, S. Azam*, M. Basche*, P. Curran*, A. Smith* ...

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Age Factors; Animals; Dependovirus / genetics; Disease Models, Animal; Dogs; Electroretinography; Fluorescein Angiography; Gene Expression; Genetic Therapy; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Humans; Leber Congenital Amaurosis / genetics; Leber Congenital Amaurosis / therapy; Retina / metabolism; Retina / pathology; Retina / physiopathology; Treatment Outcome; Vision Tests; cis-trans-Isomerases / deficiency; cis-trans-Isomerases / genetics
Source: Crossref
Added: July 20, 2019

2013 journal article

Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach

Gene Therapy, 21(1), 96–105.

By: F. Mowat*, K. Gornik*, A. Dinculescu*, S. Boye*, W. Hauswirth*, S. Petersen-Jones*, J. Bartoe*

co-author countries: United States of America 🇺🇸
author keywords: rAAV; canine; retina; capsid-mutant
MeSH headings : Amino Acid Substitution; Animals; Capsid; Dependovirus / genetics; Dependovirus / physiology; Dogs; Female; Genetic Vectors; Humans; Injections, Intraocular; Male; Mutation; Recombinant Proteins / metabolism; Retina / metabolism; Retina / virology; Transduction, Genetic; Tyrosine; Viral Tropism
Source: Crossref
Added: July 20, 2019

2012 journal article

Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy

The American Journal of Pathology, 180(4), 1726–1739.

By: F. Mowat*, F. Gonzalez*, U. Luhmann*, C. Lange*, Y. Duran*, A. Smith*, P. Maxwell*, R. Ali*, J. Bainbridge*

co-author countries: Germany 🇩🇪 Spain 🇪🇸 United Kingdom of Great Britain and Northern Ireland 🇬🇧
MeSH headings : Animals; Apoptosis / physiology; Cell Hypoxia / physiology; Disease Models, Animal; Electroretinography / methods; Erythropoietin / biosynthesis; Erythropoietin / deficiency; Erythropoietin / physiology; Erythropoietin / therapeutic use; Ischemia / complications; Ischemia / physiopathology; Kidney / metabolism; Mice; Mice, Transgenic; Oxygen; Recombinant Proteins / therapeutic use; Retina / metabolism; Retina / pathology; Retinal Neovascularization / etiology; Retinal Neovascularization / metabolism; Retinal Neovascularization / pathology; Retinal Neurons / pathology; Retinal Neurons / physiology; Retinal Vessels / pathology; Up-Regulation
Source: Crossref
Added: July 20, 2019

2012 chapter

Gene Augmentation Trials Using the Rpe65-Deficient Dog: Contributions Towards Development and Refinement of Human Clinical Trials

In M. Lavail, J. Ash, R. Anderson, J. Hollyfield, & C. Grimm (Eds.), Retinal Degenerative Diseases (pp. 177–182).

By: S. Petersen-Jones*, M. Annear*, J. Bartoe*, F. Mowat*, S. Barker, A. Smith, J. Bainbridge, R. Ali

co-author countries: United States of America 🇺🇸

Ed(s): M. Lavail, J. Ash, R. Anderson, J. Hollyfield & C. Grimm

author keywords: Leber congenital amaurosis; RPE65; Canine model; Briard; Gene therapy; Gene augmentation; AAV2; Immune response; Repeated injection; Subretinal injection
MeSH headings : Animals; Carrier Proteins / genetics; Clinical Trials, Phase I as Topic / methods; Clinical Trials, Phase II as Topic / methods; Disease Models, Animal; Dogs; Eye Proteins / genetics; Genetic Therapy / methods; Humans; Leber Congenital Amaurosis / genetics; Leber Congenital Amaurosis / immunology; Leber Congenital Amaurosis / therapy; cis-trans-Isomerases
Source: Crossref
Added: December 29, 2020

2012 journal article

RPE65 gene therapy slows cone loss in Rpe65-deficient dogs

Gene Therapy, 20(5), 545–555.

By: F. Mowat*, A. Breuwer*, J. Bartoe*, M. Annear*, Z. Zhang*, A. Smith, J. Bainbridge, S. Petersen-Jones*, R. Ali

co-author countries: United States of America 🇺🇸
author keywords: rAAV2; leber congenital amaurosis; RPE65; canine model; cone photoreceptors
MeSH headings : Animals; Cell Survival / genetics; Disease Models, Animal; Dogs; Genetic Therapy; Leber Congenital Amaurosis / genetics; Leber Congenital Amaurosis / pathology; Leber Congenital Amaurosis / therapy; Retina / drug effects; Retina / pathology; Retinal Cone Photoreceptor Cells / drug effects; Retinal Cone Photoreceptor Cells / pathology; Retinal Rod Photoreceptor Cells / drug effects; Retinal Rod Photoreceptor Cells / pathology; cis-trans-Isomerases / administration & dosage; cis-trans-Isomerases / deficiency; cis-trans-Isomerases / genetics
Source: Crossref
Added: July 20, 2019

2012 journal article

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

Development, 139(13), 2340–2350.

By: C. Lange*, U. Luhmann*, F. Mowat*, A. Georgiadis*, E. West*, S. Abrahams, H. Sayed*, M. Powner* ...

co-author countries: Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧
author keywords: Von Hippel-Lindau factor; Hypoxia-inducible factor 1; Microphthalmia; Angiogenesis; Mouse
MeSH headings : Animals; Aniridia / genetics; Aniridia / pathology; Apoptosis / genetics; Basic Helix-Loop-Helix Transcription Factors / analysis; Cell Proliferation; Electroretinography; Erythropoietin / metabolism; Eye / blood supply; Eye / cytology; Eye / growth & development; Gene Deletion; Hypoxia-Inducible Factor 1, alpha Subunit / physiology; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microphthalmos / genetics; Microphthalmos / pathology; Retinal Pigment Epithelium / cytology; Retinal Pigment Epithelium / growth & development; Vascular Endothelial Growth Factor A / analysis; Von Hippel-Lindau Tumor Suppressor Protein / genetics; Von Hippel-Lindau Tumor Suppressor Protein / physiology
Source: Crossref
Added: July 20, 2019

2010 journal article

HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia

PLoS ONE, 5(6), e11103.

By: F. Mowat*, U. Luhmann*, A. Smith*, C. Lange*, Y. Duran*, S. Harten*, D. Shukla*, P. Maxwell*, R. Ali*, J. Bainbridge*

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧

Ed(s): K. Koch

MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / metabolism; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Erythropoietin / metabolism; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Immunohistochemistry; Ischemia / metabolism; Mice; Retinal Vessels / metabolism; Vascular Endothelial Growth Factor A / metabolism
Source: Crossref
Added: July 20, 2019

2010 journal article

The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice

PLoS ONE, 5(12), e15730.

By: A. Georgiadis*, M. Tschernutter*, J. Bainbridge*, K. Balaggan*, F. Mowat*, E. West*, P. Munro*, A. Thrasher* ...

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧

Ed(s): M. Klymkowsky

MeSH headings : Angiography / methods; Animals; Cell Adhesion; DNA-Binding Proteins / genetics; DNA-Binding Proteins / physiology; Epithelium / metabolism; Female; Homeostasis; Macular Degeneration / genetics; Membrane Proteins / metabolism; Mesoderm / metabolism; Mice; Mice, Inbred C57BL; Microscopy, Electron / methods; Phosphoproteins / metabolism; Retinal Diseases / genetics; Retinal Pigment Epithelium / metabolism; Signal Transduction; Transcription Factors; Zonula Occludens-1 Protein
Source: Crossref
Added: July 20, 2019

2008 journal article

Topographical characterization of cone photoreceptors and the area centralis of the canine retina

Molecular Vision, 14, 2518–2527.

By: F. Mowat, S. Petersen-Jones, H. Williamson, D. Williams, P. Luthert, R. Ali, J. Bainbridge

Source: NC State University Libraries
Added: September 8, 2019