Works (38)
Updated: July 18th, 2024 05:02
2024 journal article
Differential gene expression between central and peripheral retinal regions in dogs and comparison with humans
EXPERIMENTAL EYE RESEARCH, 245.
author keywords: RNAseq; Canine; Animal model; Macula; Inherited retinal disease; Age -related macular degeneration
Source: Web Of Science
Added: July 17, 2024
2023 article
Age-associated changes in electroretinography measures in companion dogs
Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). DOCUMENTA OPHTHALMOLOGICA, Vol. 6.
author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
TL;DR:
Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs, as aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023
2023 article
Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome
Lynch, A. M. M., Ruterbories, L. K. K., Robertson, J. B. B., Lunn, K. F. F., & Mowat, F. M. M. (2023, April 19). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 4.
author keywords: coagulation; fibrinogen; hypercoagulability; SARDS
MeSH headings : Dogs; Animals; Retinal Degeneration / veterinary; Case-Control Studies; Hemostatics; Pilot Projects; Thrombophilia / complications; Thrombophilia / veterinary; Fibrinogen; Antithrombins; Thrombelastography / veterinary; Dog Diseases
TL;DR:
Hypercoagulability was common in both dogs with SARDS and controls, but dogs with ARDS were significantly more hypercoagULable on TEG, which remains to be determined.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 20, 2023
2022 journal article
Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population
JOURNAL OF ALZHEIMERS DISEASE, 87(3), 1367–1378.
author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
TL;DR:
It is suggested that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022
2021 journal article
A modified silent substitution electroretinography protocol to separate photoreceptor subclass function in lightly sedated dogs
VETERINARY OPHTHALMOLOGY, 24(1), 103–107.
author keywords: electroretinography; L/M-cone; photoreceptor; rod; S-cone; silent substitution
MeSH headings : Analgesics, Opioid / administration & dosage; Animals; Butorphanol / administration & dosage; Dexmedetomidine / administration & dosage; Dogs / anatomy & histology; Dogs / physiology; Electroretinography / methods; Electroretinography / veterinary; Female; Hypnotics and Sedatives / administration & dosage; Male; Photoreceptor Cells, Vertebrate / classification; Photoreceptor Cells, Vertebrate / physiology
TL;DR:
A clinically applicable method to consistently isolate rod and cone subclass function in sedated dogs may allow detailed evaluation of photoreceptor function in clinical patients with rod or cone subclass deficits without the need for general anesthesia or protracted adaptation times.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 11, 2020
2021 journal article
Canine sudden acquired retinal degeneration syndrome: Owner perceptions on the time to vision loss, treatment outcomes, and prognosis for life
VETERINARY OPHTHALMOLOGY, 24(2), 156–168.
author keywords: dog; onset time; prognosis; SARDS; treatment
MeSH headings : Animals; Blindness / veterinary; Dog Diseases / physiopathology; Dog Diseases / therapy; Dogs; Prognosis; Retinal Degeneration / physiopathology; Retinal Degeneration / veterinary; Risk Assessment; Surveys and Questionnaires; Time Perception; Treatment Outcome
TL;DR:
Dogs with SARDS have a rapid onset of vision loss and treatment is unlikely to restore vision and is associated with systemic side effects, and the potential for systemic pathologies that arise after SARDS diagnosis warrants further study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 19, 2021
2021 journal article
Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs
MOLECULAR NEUROBIOLOGY, 58(2), 483–489.
Contributors: W. Panek n , D. Murdoch *, M. Gruen n , n, R. Marek* & N. Olby n
author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; CDS; Amyloid beta 42; Amyloid beta 40
MeSH headings : Aging / blood; Amyloid beta-Peptides / blood; Animals; Cognitive Dysfunction / blood; Dogs / blood; Female; Male; Pets / blood
TL;DR:
The findings suggest the dynamics of canine plasma amyloid concentrations are analogous to that found in aging humans with and without AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020
2021 journal article
Retinal cone photoreceptor distribution in the American black bear (Ursus americanus)
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 304(3), 662–672.
author keywords: black bear; cone; photoreceptor; retina; topography
MeSH headings : Animals; Retina / metabolism; Retinal Cone Photoreceptor Cells / metabolism; Ursidae; Vision, Ocular / physiology
TL;DR:
Examining the subtype and topography of cones in American black bear retinas confirmed that American black bears are predicted to have a dichromatic vision with high acuity indicated by the presence of a dorsotemporally located area centralis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: July 13, 2020
2020 journal article
Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: A case control study
EXPERIMENTAL EYE RESEARCH, 193.
author keywords: SARDS; Dog; Retina; Immune-mediated; IgG; IgM
MeSH headings : Animals; Autoantibodies / immunology; Blotting, Western; Case-Control Studies; Disease Models, Animal; Dogs; Fluorescent Antibody Technique, Indirect / methods; Retina / immunology; Retina / metabolism; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / immunology; Retinal Degeneration / metabolism; Syndrome
TL;DR:
Despite having decreased serum IgG compared with healthy controls, circulating IgG in dogs with SARDS binds photoreceptor outer segments to a greater extent than matched healthy controls.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020
2020 journal article
MOLECULAR PREVALENCE OF SELECTED VECTOR-BORNE ORGANISMS IN CAPTIVE RED WOLVES (CANIS RUFUS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 51(3), 663–667.
MeSH headings : Animals; Animals, Zoo; Endangered Species; Molecular Epidemiology; Prevalence; United States / epidemiology; Vector Borne Diseases / epidemiology; Vector Borne Diseases / microbiology; Vector Borne Diseases / parasitology; Vector Borne Diseases / veterinary; Wolves
TL;DR:
Assessment of the prevalence of selected vector-borne pathogens in captive red wolves established a baseline that may facilitate ongoing disease monitoring in this species and are unlikely to constitute threats to red wolf conservation and breeding efforts under current captive management conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2021
2020 journal article
Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs
MOLECULAR NEUROBIOLOGY, 57(7), 3143–3149.
Contributors: W. Panek n , M. Gruen n , D. Murdoch *, R. Marek*, A. Stachel n, *, K. Saker n, N. Olby n
author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; Amyotrophic lateral sclerosis; Degenerative myelopathy
TL;DR:
This work identified plasma NfL as a key clinical index of neuro-aging and neurodegeneration in pet dogs using an ultrasensitive single-molecule array assay to measure plasma concentrations and found it increases in an age-dependent manner and is significantly elevated in dogs diagnosed with Neurodegenerative disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 13, 2020
2019 journal article
Circulating neurohormone imbalances in canine sudden acquired retinal degeneration syndrome and canine pituitary-dependent hypercortisolism
JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(6), 2587–2594.
author keywords: dog; dopamine; melatonin; PDH; retina; SARDS; serotonin
MeSH headings : Animals; Case-Control Studies; Dog Diseases / blood; Dog Diseases / metabolism; Dogs; Dopamine / blood; Melatonin / analogs & derivatives; Melatonin / blood; Melatonin / urine; Pituitary ACTH Hypersecretion / blood; Pituitary ACTH Hypersecretion / metabolism; Pituitary ACTH Hypersecretion / veterinary; Prospective Studies; Retinal Degeneration / blood; Retinal Degeneration / metabolism; Retinal Degeneration / veterinary; Serotonin / blood
TL;DR:
This study has identified neurohormone differences between dogs with SARDS and PDH, although the study was underpowered for detection of significant differences in serum serotonin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 11, 2019
2019 journal article
Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary‐dependent hyperadrenocorticism in dogs
Veterinary Ophthalmology, 22(6), 842–858.
author keywords: biomarker; dog; hyperadrenocorticism; retina; sudden acquired retinal degeneration syndrome
MeSH headings : Animals; Case-Control Studies; Dog Diseases / diagnosis; Dogs; Electroretinography / veterinary; Female; Male; Pituitary ACTH Hypersecretion / diagnosis; Pituitary ACTH Hypersecretion / veterinary; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / veterinary; Tomography, Optical Coherence / veterinary
TL;DR:
This work provides the basis for future studies that could identify and examine dogs with SARDS prior to vision loss, which may extend the potential therapeutic window for SARDS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 16, 2019
2019 journal article
In vivo electroretinographic differentiation of rod, short-wavelength and long/medium-wavelength cone responses in dogs using silent substitution stimuli
EXPERIMENTAL EYE RESEARCH, 185.
author keywords: dog; Silent substitution; S-Cone; L/M-cone; Rod; Photoreceptor; Electroretinogram; Congenital stationary night blindness
MeSH headings : Animals; Cone Opsins / metabolism; Dark Adaptation; Disease Models, Animal; Dogs; Electroretinography / methods; Eye Diseases, Hereditary / metabolism; Eye Diseases, Hereditary / physiopathology; Female; Genetic Diseases, X-Linked / metabolism; Genetic Diseases, X-Linked / physiopathology; Male; Myopia / metabolism; Myopia / physiopathology; Night Blindness / metabolism; Night Blindness / physiopathology; Retina / metabolism; Retina / physiopathology; Retinal Cone Photoreceptor Cells / physiology; Retinal Rod Photoreceptor Cells / physiology
TL;DR:
Methods to differentiate rod, S- and L/M-cone function in dogs using silent substitution methods have been developed and the influence of temporal frequency and mean luminance on the ERGs originating in each photoreceptor type can now be studied independently.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 16, 2019
2019 article
Naturally Occurring Inherited Forms of Retinal Degeneration in Vertebrate Animal Species: A Comparative and Evolutionary Perspective
RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY, Vol. 1185, pp. 239–243.
author keywords: Genetic; Animal model; Naturally occurring; Carnivore; Nondomestic; Retinal phenotype; Retinitis pigmentosa; Leber's congenital amaurosis; Retinal degeneration
TL;DR:
In this chapter, the advantages and disadvantages of transgenic and spontaneous vertebrate animal models of human inherited retinal disease are debated, in particular those of carnivore species, and the potential resource of spontaneous heritable retinal disorders in inbred nondomestic carnivorespecies is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 10, 2020
2019 journal article
Safety and efficacy of topically applied 0.5% and 1% pirfenidone in a canine model of subconjunctival fibrosis
VETERINARY OPHTHALMOLOGY, 22(4), 502–509.
MeSH headings : Administration, Topical; Animals; Aqueous Humor / drug effects; Conjunctival Diseases / drug therapy; Conjunctival Diseases / pathology; Conjunctival Diseases / veterinary; Disease Models, Animal; Dogs; Drug Implants; Female; Fibrosis / drug therapy; Fibrosis / veterinary; Pyridones / administration & dosage; Pyridones / therapeutic use; Random Allocation
TL;DR:
Pfenidone may decrease fibrosis following glaucoma shunt surgery and can potentially be used indefinitely due to minimal side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 5, 2019
2019 journal article
Use of a Versatile, Inexpensive Ophthalmoscopy Teaching Model in Veterinary Medical Student Education Increases Ophthalmoscopy Proficiency
JOURNAL OF VETERINARY MEDICAL EDUCATION, 46(4), 518–522.
author keywords: teaching ophthalmoscopy; fundus model; veterinary education
MeSH headings : Animals; Education, Veterinary; Fundus Oculi; Humans; Ophthalmology / education; Ophthalmoscopy; Students, Medical; Teaching
TL;DR:
The model used in this study is well received by students and results in discernible gains in proficiency, and all students who used the model stated the models should continue to be used to aid student learning.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 27, 2020
2018 journal article
Clinical findings and outcomes for dogs with uveodermatologic syndrome
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 252(10), 1263–1271.
MeSH headings : Animals; Cohort Studies; Dermatitis, Perioral / complications; Dermatitis, Perioral / diagnosis; Dermatitis, Perioral / epidemiology; Dermatitis, Perioral / veterinary; Dog Diseases / diagnosis; Dog Diseases / epidemiology; Dogs; Female; Glaucoma / complications; Glaucoma / diagnosis; Glaucoma / epidemiology; Glaucoma / veterinary; Male; Pedigree; Records / veterinary; Retrospective Studies; Syndrome; United States / epidemiology; Uveitis / complications; Uveitis / diagnosis; Uveitis / epidemiology; Uveitis / veterinary
TL;DR:
No evaluated factor was associated with visual prognosis; however, a subset of patients maintained vision through to the final recheck examination, suggesting UDS commonly resulted in glaucoma, vision loss, or both in affected dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Clinical therapeutic efficacy of mycophenolate mofetil in the treatment of SARDS in dogs-a prospective open-label pilot study
VETERINARY OPHTHALMOLOGY, 21(6), 565–576.
author keywords: dog; mycophenolate mofetil; retina; sudden acquired retinal degeneration syndrome; treatment; vision
MeSH headings : Animals; Dog Diseases / drug therapy; Dogs; Female; Immunosuppressive Agents / therapeutic use; Male; Mycophenolic Acid / therapeutic use; Pilot Projects; Prospective Studies; Retinal Degeneration / drug therapy; Retinal Degeneration / veterinary; Vision Tests / veterinary
TL;DR:
The effect of sole-agent treatment with mycophenolate mofetil as a sole agent has no measureable positive effect on physical health, vision, or retinal structure following a 6-week trial period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018
2018 journal article
Ophthalmoscopy skills in primary care: a cross-sectional practitioner survey
VETERINARY RECORD, 182(15), 435-+.
MeSH headings : Animals; Clinical Competence; Cross-Sectional Studies; Education, Veterinary; Health Care Surveys; Humans; Ophthalmoscopy / statistics & numerical data; Ophthalmoscopy / veterinary; Primary Health Care; Self Efficacy; United States; Veterinarians / psychology
TL;DR:
Since in some cases of systemic illness ophthalmic manifestations may be the only changes present on physical examination, inability to perform comprehensive funduscopic examination may result in delay in diagnosis and poorer patient outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
4. Quality Education
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Phenotypic characterization of complete CSNB in the inbred research beagle: how common is CSNB in research and companion dogs?
DOCUMENTA OPHTHALMOLOGICA, 137(2), 87–101.
author keywords: Congenital stationary night blindness; Dog; Electroretinography; Complete; Retina
MeSH headings : Adaptation, Ocular / physiology; Animals; Animals, Inbred Strains; Dark Adaptation / physiology; Dogs; Electroretinography; Eye Diseases, Hereditary / physiopathology; Genetic Diseases, X-Linked / physiopathology; Myopia / physiopathology; Night Blindness / physiopathology; Phenotype; Refraction, Ocular / physiology; Retina / physiopathology; Retinal Bipolar Cells / physiology; Retinal Rod Photoreceptor Cells / physiology; Retrospective Studies; Vision, Ocular / physiology
TL;DR:
CSNB appears to be a rare disorder in the wider beagle population, although its detection could confound studies that use retinal function as an outcome measure in research dogs, necessitating careful baseline studies to be performed prior to experimentation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2017 journal article
Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(7), 3268–3277.
author keywords: canine model; LCA2; RPE65; cone photoreceptors; retinal degeneration; fovea; area centralis
MeSH headings : Analysis of Variance; Animals; Disease Models, Animal; Dogs; Female; Fovea Centralis / pathology; Immunohistochemistry; Male; Retinal Cone Photoreceptor Cells / pathology; Retinal Degeneration / pathology; Retinal Rod Photoreceptor Cells / pathology; Tomography, Optical Coherence; Visual Acuity; cis-trans-Isomerases / deficiency
TL;DR:
Early-onset severe photoreceptor degeneration in the area centralis of dogs with RPE65-deficiency offers a model of the early foveal/perifoveal degeneration during Leber congenital amaurosis type-2 patients with LCA2, and could be used to refine interventions aiming to improve function and halt the progression of foveale/perIFoveal photoreceptors degeneration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Gene Therapy in a Large Animal Model of PDE6A-Retinitis Pigmentosa
FRONTIERS IN NEUROSCIENCE, 11.
author keywords: retinitis pigmentosa; Pde6 mutation; gene therapy; canine model; adeno-associated virus
TL;DR:
This is the first description of successful gene augmentation for Pde6a retinitis pigmentosa in a large animal model and further studies will be necessary to optimize visual outcomes and minimize complications before translation to human studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis
EXPERIMENTAL EYE RESEARCH, 147, 148–155.
author keywords: DDAH1; DDAH2; ADMA; Nitric oxide; Angiogenesis; Retinal neovascularization
MeSH headings : Amidohydrolases / deficiency; Amidohydrolases / metabolism; Animals; Choroidal Neovascularization / metabolism; Choroidal Neovascularization / physiopathology; Disease Models, Animal; Electroretinography; Immunohistochemistry; Ischemia / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic / metabolism; Nitric Oxide / metabolism; Retinal Neovascularization / metabolism; Retinal Neovascularization / physiopathology; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
It is suggested that in retinal ischemia, DDAH2 deficiency elevates ADMA, promotes vascular regeneration and protects against aberrant angiogenesis, and therapeutic inhibition of DDAh2 may offer a potential therapeutic strategy to protect sight.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Evaluation of the proliferative capacity of canine retinal pigment epithelial cells harvested from different regions of the fundus
Investigative Ophthalmology and Visual Science, 57(12).
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
New England Journal of Medicine, 372(20), 1887–1897.
MeSH headings : Adolescent; Animals; Child; DNA, Complementary / administration & dosage; Dependovirus; Disease Models, Animal; Disease Progression; Dogs; Genetic Therapy; Genetic Vectors / administration & dosage; Humans; Leber Congenital Amaurosis / genetics; Leber Congenital Amaurosis / therapy; Mutation; Photoreceptor Cells, Vertebrate; Retina / physiology; Vision, Ocular; Young Adult; cis-trans-Isomerases / genetics
TL;DR:
In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG, and comparison with the results obtained in the dog model indicates that there is a species difference in the amount of R PE65 required to drive the visual cycle.
(via Semantic Scholar)
Source: Crossref
Added: February 21, 2020
2014 journal article
Assessment of a novel pigmentary chorioretinopathy in the Chinese Crested dog
JSciMed Ophthalmology, 2(2), 1018.
Source: NC State University Libraries
Added: September 8, 2019
2014 journal article
Differential targeting of feline photoreceptors by recombinant adeno-associated viral vectors: implications for preclinical gene therapy trials
Gene Therapy, 21(10), 913–920.
MeSH headings : Animals; Cats; Dependovirus / genetics; Dependovirus / physiology; Female; Genetic Therapy; Genetic Vectors / administration & dosage; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Injections, Intraocular; Male; Mice; Retinal Cone Photoreceptor Cells / metabolism; Retinal Cone Photoreceptor Cells / virology; Retinal Rod Photoreceptor Cells / metabolism; Retinal Rod Photoreceptor Cells / virology; Transduction, Genetic; Viral Tropism
TL;DR:
It is concluded that rAAV serotypes are suitable for use for retinal gene therapy in feline models, particularly when cone photoreceptors are the target cell.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2013 journal article
Evaluation of Lateral Spread of Transgene Expression following Subretinal AAV–Mediated Gene Delivery in Dogs
PLoS ONE, 8(4), e60218.
Ed(s): T. Li*
MeSH headings : Actins / genetics; Actins / metabolism; Animals; Capsid Proteins / genetics; Capsid Proteins / metabolism; Chickens; Dependovirus / genetics; Dependovirus / metabolism; Dogs; Electroretinography; Genes, Reporter; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; Injections, Intraocular; Male; Microscopy, Fluorescence; Optic Nerve / ultrastructure; Optic Nerve / virology; Promoter Regions, Genetic; Retina / ultrastructure; Retina / virology; Retinal Detachment / physiopathology; Retinal Detachment / virology; Virus Replication
TL;DR:
A detailed study of the lateral spread of transgene expression beyond the subretinal injection site following subretinally delivered AAV vectors in normal dogs found that in all eyes GFP expression involved retina beyond the initial post-injection sub retinal bleb boundary.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2013 journal article
Successful Gene Therapy in Older Rpe65-Deficient Dogs Following Subretinal Injection of an Adeno-Associated Vector Expressing RPE65
Human Gene Therapy, 24(10), 883–893.
MeSH headings : Age Factors; Animals; Dependovirus / genetics; Disease Models, Animal; Dogs; Electroretinography; Fluorescein Angiography; Gene Expression; Genetic Therapy; Genetic Vectors / administration & dosage; Genetic Vectors / genetics; Humans; Leber Congenital Amaurosis / genetics; Leber Congenital Amaurosis / therapy; Retina / metabolism; Retina / pathology; Retina / physiopathology; Treatment Outcome; Vision Tests; cis-trans-Isomerases / deficiency; cis-trans-Isomerases / genetics
TL;DR:
It is concluded that functional rescue is still possible in older dogs and that the use of older Rpe65-deficient dogs, rather than young RPE65- deficient dogs that have very little loss of photoreceptors, more accurately models the situation when treating human R PE65-LCA patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2013 journal article
Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach
Gene Therapy, 21(1), 96–105.
author keywords: rAAV; canine; retina; capsid-mutant
MeSH headings : Amino Acid Substitution; Animals; Capsid; Dependovirus / genetics; Dependovirus / physiology; Dogs; Female; Genetic Vectors; Humans; Injections, Intraocular; Male; Mutation; Recombinant Proteins / metabolism; Retina / metabolism; Retina / virology; Transduction, Genetic; Tyrosine; Viral Tropism
TL;DR:
Subretinally delivered capsid-mutant AAV8 vectors may increase the efficacy of gene therapy treatment for rapid photoreceptor degenerative diseases and show promise for retinal gene delivery from an intravitreal approach.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2012 journal article
Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy
The American Journal of Pathology, 180(4), 1726–1739.
MeSH headings : Animals; Apoptosis / physiology; Cell Hypoxia / physiology; Disease Models, Animal; Electroretinography / methods; Erythropoietin / biosynthesis; Erythropoietin / deficiency; Erythropoietin / physiology; Erythropoietin / therapeutic use; Ischemia / complications; Ischemia / physiopathology; Kidney / metabolism; Mice; Mice, Transgenic; Oxygen; Recombinant Proteins / therapeutic use; Retina / metabolism; Retina / pathology; Retinal Neovascularization / etiology; Retinal Neovascularization / metabolism; Retinal Neovascularization / pathology; Retinal Neurons / pathology; Retinal Neurons / physiology; Retinal Vessels / pathology; Up-Regulation
Source: Crossref
Added: July 20, 2019
2012 chapter
Gene Augmentation Trials Using the Rpe65-Deficient Dog: Contributions Towards Development and Refinement of Human Clinical Trials
In M. Lavail, J. Ash, R. Anderson, J. Hollyfield, & C. Grimm (Eds.), Retinal Degenerative Diseases (pp. 177–182).
Ed(s): M. Lavail, J. Ash, R. Anderson, J. Hollyfield & C. Grimm
author keywords: Leber congenital amaurosis; RPE65; Canine model; Briard; Gene therapy; Gene augmentation; AAV2; Immune response; Repeated injection; Subretinal injection
MeSH headings : Animals; Carrier Proteins / genetics; Clinical Trials, Phase I as Topic / methods; Clinical Trials, Phase II as Topic / methods; Disease Models, Animal; Dogs; Eye Proteins / genetics; Genetic Therapy / methods; Humans; Leber Congenital Amaurosis / genetics; Leber Congenital Amaurosis / immunology; Leber Congenital Amaurosis / therapy; cis-trans-Isomerases
TL;DR:
Dogs with a spontaneous mutation in Rpe65 have been key in the testing of gene augmentation therapy using viral vectors to introduce a normal copy of the Rpe55 gene, leading to human clinical trials for treatment of Leber congenital amaurosis type II.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: December 29, 2020
2012 journal article
RPE65 gene therapy slows cone loss in Rpe65-deficient dogs
Gene Therapy, 20(5), 545–555.
author keywords: rAAV2; leber congenital amaurosis; RPE65; canine model; cone photoreceptors
MeSH headings : Animals; Cell Survival / genetics; Disease Models, Animal; Dogs; Genetic Therapy; Leber Congenital Amaurosis / genetics; Leber Congenital Amaurosis / pathology; Leber Congenital Amaurosis / therapy; Retina / drug effects; Retina / pathology; Retinal Cone Photoreceptor Cells / drug effects; Retinal Cone Photoreceptor Cells / pathology; Retinal Rod Photoreceptor Cells / drug effects; Retinal Rod Photoreceptor Cells / pathology; cis-trans-Isomerases / administration & dosage; cis-trans-Isomerases / deficiency; cis-trans-Isomerases / genetics
TL;DR:
The results suggest that gene therapy may be able to slow cone degeneration in patients if intervention is sufficiently early and also that it is probably important to treat the macula in order to preserve central function.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2012 journal article
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development
Development, 139(13), 2340–2350.
author keywords: Von Hippel-Lindau factor; Hypoxia-inducible factor 1; Microphthalmia; Angiogenesis; Mouse
MeSH headings : Animals; Aniridia / genetics; Aniridia / pathology; Apoptosis / genetics; Basic Helix-Loop-Helix Transcription Factors / analysis; Cell Proliferation; Electroretinography; Erythropoietin / metabolism; Eye / blood supply; Eye / cytology; Eye / growth & development; Gene Deletion; Hypoxia-Inducible Factor 1, alpha Subunit / physiology; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microphthalmos / genetics; Microphthalmos / pathology; Retinal Pigment Epithelium / cytology; Retinal Pigment Epithelium / growth & development; Vascular Endothelial Growth Factor A / analysis; Von Hippel-Lindau Tumor Suppressor Protein / genetics; Von Hippel-Lindau Tumor Suppressor Protein / physiology
TL;DR:
Vhl-dependent regulation of Hif1a in the RPE is essential for normal RPE and iris development, ocular growth and vascular development in the anterior chamber, whereas Vhl- dependent regulation of other downstream pathways is crucial for normal development and maintenance of the retinal vasculature.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2010 journal article
HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia
PLoS ONE, 5(6), e11103.
Ed(s): K. Koch
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / metabolism; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Erythropoietin / metabolism; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Immunohistochemistry; Ischemia / metabolism; Mice; Retinal Vessels / metabolism; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
The findings suggest that HIF-2alpha activation plays a key role in regulating the response of Müller glia to hypoxia, consistent with differential roles in retinal ischaemia.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2010 journal article
The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice
PLoS ONE, 5(12), e15730.
Ed(s): M. Klymkowsky
MeSH headings : Angiography / methods; Animals; Cell Adhesion; DNA-Binding Proteins / genetics; DNA-Binding Proteins / physiology; Epithelium / metabolism; Female; Homeostasis; Macular Degeneration / genetics; Membrane Proteins / metabolism; Mesoderm / metabolism; Mice; Mice, Inbred C57BL; Microscopy, Electron / methods; Phosphoproteins / metabolism; Retinal Diseases / genetics; Retinal Pigment Epithelium / metabolism; Signal Transduction; Transcription Factors; Zonula Occludens-1 Protein
TL;DR:
It is demonstrated that ZO-1 and ZONAB are critical for differentiation and homeostasis of the RPE monolayer and may be involved in RPE disorders such as proliferative vitroretinopathy and atrophic age-related macular degeneration.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2008 journal article
Topographical characterization of cone photoreceptors and the area centralis of the canine retina
Molecular Vision, 14, 2518–2527.
Source: NC State University Libraries
Added: September 8, 2019
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