Works (5)
Updated: July 5th, 2023 15:56
2014 journal article
Studies toward the Total Synthesis of Dihydrolycolucine. Preparation of AB and CEF Ring Fragments
JOURNAL OF ORGANIC CHEMISTRY, 79(12), 5740–5745.
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Lycopodium / chemistry; Molecular Structure; Pyridinium Compounds / chemistry; Quinolines / chemical synthesis; Quinolines / chemistry; Stereoisomerism
TL;DR:
A strategy for the synthesis of the lycopodium alkaloid dihydrolycolucine was investigated and key reactions include IMDA cycloadditions and retro-Mannich ring-openings to form both the AB and the EF ring fragments.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Recent advances in the synthesis of nicotine and its derivatives
TETRAHEDRON, 63(34), 8065–8082.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Expedient five-step synthesis of SIB-1508Y from natural nicotine
JOURNAL OF ORGANIC CHEMISTRY, 71(22), 8673–8675.
MeSH headings : Antiparkinson Agents / chemical synthesis; Antiparkinson Agents / chemistry; Molecular Structure; Nicotine / chemistry; Pyridines / chemical synthesis; Pyridines / chemistry; Pyrrolidines / chemical synthesis; Pyrrolidines / chemistry; Stereoisomerism
TL;DR:
Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Regioselective 5-, 4-, and 2-substitution of (S)-6-chloronicotine and 4-substitution of (S)-5-chloronicotine
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2006(16), 3562–3565.
author keywords: nicotine; lithiation; iodine dance; regioselectivity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Six-step synthesis of (S)-brevicolline from (S)-nicotine
ORGANIC LETTERS, 8(16), 3549–3552.
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / isolation & purification; Carbolines / chemical synthesis; Carbolines / chemistry; Carbolines / isolation & purification; Carex Plant / chemistry; Indoles / chemistry; Indoles / isolation & purification; Molecular Structure; Nicotine / chemistry; Stereoisomerism
TL;DR:
A six-step synthesis of (S)-brevicolline from (S) nicotine, followed by successive Suzuki cross-coupling and Buchwald amination reactions, afforded the enantiopure beta-carboline alkaloid, brevicollines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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