Florence F. Wagner

Works (5)

Updated: July 5th, 2023 15:56

2014 article

Studies toward the Total Synthesis of Dihydrolycolucine. Preparation of AB and CEF Ring Fragments

Cash, B. M., Prevost, N., Wagner, F. F., & Comins, D. L. (2014, May 19). The Journal of Organic Chemistry.

By: B. Cash n, N. Prevost n, F. Wagner n & D. Comins n

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Lycopodium / chemistry; Molecular Structure; Pyridinium Compounds / chemistry; Quinolines / chemical synthesis; Quinolines / chemistry; Stereoisomerism
topics (OpenAlex): Cholinesterase and Neurodegenerative Diseases; Synthetic Organic Chemistry Methods; Chemical synthesis and alkaloids
TL;DR: A strategy for the synthesis of the lycopodium alkaloid dihydrolycolucine was investigated and key reactions include IMDA cycloadditions and retro-Mannich ring-openings to form both the AB and the EF ring fragments. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Recent advances in the synthesis of nicotine and its derivatives

Wagner, F. F., & Comins, D. L. (2007, May 4). Tetrahedron.

By: F. Wagner n & D. Comins n

topics (OpenAlex): Nicotinic Acetylcholine Receptors Study; Synthesis and Biological Evaluation; Pharmacological Receptor Mechanisms and Effects
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Source: Web Of Science
Added: August 6, 2018

2006 article

Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine

Wagner, F. F., & Comins, D. L. (2006, October 1). The Journal of Organic Chemistry.

By: F. Wagner n & D. Comins n

MeSH headings : Antiparkinson Agents / chemical synthesis; Antiparkinson Agents / chemistry; Molecular Structure; Nicotine / chemistry; Pyridines / chemical synthesis; Pyridines / chemistry; Pyrrolidines / chemical synthesis; Pyrrolidines / chemistry; Stereoisomerism
topics (OpenAlex): Chemical Synthesis and Analysis; Nicotinic Acetylcholine Receptors Study; Asymmetric Synthesis and Catalysis
TL;DR: Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

Regioselective 5‐, 4‐, and 2‐Substitution of (S)‐6‐Chloronicotine and 4‐Substitution of (S)‐5‐Chloronicotine

Wagner, F. F., & Comins, D. L. (2006, August 1). European Journal of Organic Chemistry.

By: F. Wagner n & D. Comins n

author keywords: nicotine; lithiation; iodine dance; regioselectivity
topics (OpenAlex): Synthesis and Reactivity of Sulfur-Containing Compounds; Coordination Chemistry and Organometallics
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Source: Web Of Science
Added: August 6, 2018

2006 article

Six-Step Synthesis of (S)-Brevicolline from (S)-Nicotine

Wagner, F. F., & Comins, D. L. (2006, July 13). Organic Letters.

By: F. Wagner n & D. Comins n

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / isolation & purification; Carbolines / chemical synthesis; Carbolines / chemistry; Carbolines / isolation & purification; Carex Plant / chemistry; Indoles / chemistry; Indoles / isolation & purification; Molecular Structure; Nicotine / chemistry; Stereoisomerism
topics (OpenAlex): Alkaloids: synthesis and pharmacology; Chemical synthesis and alkaloids; Synthesis and bioactivity of alkaloids
TL;DR: A six-step synthesis of (S)-brevicolline from (S) nicotine, followed by successive Suzuki cross-coupling and Buchwald amination reactions, afforded the enantiopure beta-carboline alkaloid, brevicollines. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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