Fan Zhang
Tissue Engineering, Biomaterial, Immunoengineering, Drug Delivery, Coronary Artery Bypass Graft, Tissue-engineered Vascular Graft, macrophage
Fan Zhang (she/her/hers) is a postdoc at UW in the Department of Bioengineering. Fan received her Ph.D. degree in Fiber and Polymer Science in Dr. Martin King’s lab at North Carolina State University, engineering immunomodulatory biomaterials for tissue-engineered vascular graft. Fan’s current research focuses on understanding the mechanism underlying biomaterial-induced vascularization.
Works (11)
Updated: July 23rd, 2023 21:13
2023 article
A textile-reinforced composite vascular graft that modulates macrophage polarization and enhances endothelial cell migration, adhesion and proliferation in vitro
Zhang, F., Tao, H., Gluck, J. M., Wang, L., Daneshmand, M. A., & King, M. W. (2023, January 20). SOFT MATTER, Vol. 1.
MeSH headings : Endothelial Cells; Macrophage Activation; Textiles; Hydrogels; Cell Proliferation; Macrophages; Tissue Engineering
TL;DR:
The textile-reinforced hydrogel shows it potential to be a promising scaffold material to fabricate a tissue engineered vascular graft and improves the survival, adhesion and proliferation of endothelial cells in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 9, 2023
2023 journal article
Effects of sterilization methods on gelatin methacryloyl hydrogel properties and macrophage gene expression in vitro
BIOMEDICAL MATERIALS, 18(1).
author keywords: gelatin methacryloyl; hydrogel; sterilization; macrophage phenotype; gene expression
MeSH headings : Hydrogels; Macrophages
TL;DR:
It was found that the sterilization methods only marginally altered the hydrogel morphology, swelling behavior and elastic modulus, but significantly impacted macrophage gene expression within 48 h and over 7 d in vitro, suggesting that not only the sterility and hydrogels properties, such as material destruction and degradation caused by temperature and moisture, should be taken into consideration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 22, 2022
2023 journal article
Heparin Affinity-Based IL-4 Delivery to Modulate Macrophage Phenotype and Endothelial Cell Activity In Vitro
ACS APPLIED MATERIALS & INTERFACES, 15(23), 27457–27470.
author keywords: gelatin methacryloyl; heparin; interleukin4; hydrogel; macrophage; endothelial cell; immunomodulation
MeSH headings : Interleukin-4 / pharmacology; Heparin / pharmacology; Heparin / metabolism; Macrophages / metabolism; Phenotype; Hydrogels / pharmacology; Hydrogels / metabolism
TL;DR:
A gelatin-heparin-methacrylate hydrogel is engineered that gradually releases interleukin-4 (IL-4), a cytokine that modulates macrophages to adopt the M2 phenotype and synergistically downregulated M1 gene expression and upregulated M2 gene expression within 48 h of in vitro cell culture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 26, 2023
2022 article
A collagen/PLA hybrid scaffold supports tendon-derived cell growth for tendon repair and regeneration
Xie, Y., Zhang, F., Akkus, O., & King, M. W. (2022, July 2). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol. 7.
author keywords: biomaterials; biotextiles; collagen yarn; tendon regeneration; tissue engineering scaffold
MeSH headings : Cell Proliferation; Collagen; Humans; Polyesters; Regeneration; Rotator Cuff Injuries; Tendons; Tissue Engineering; Tissue Scaffolds
TL;DR:
Combining the mechanical robustness of PLA and the biological activity of collagen, the woven COL/PLA hybrid scaffold has shown its potential to be a promising candidate for tendon repair applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 3, 2022
2022 article
Immunomodulation Strategies for the Successful Regeneration of a Tissue-Engineered Vascular Graft
Zhang, F., & King, M. W. (2022, March 27). ADVANCED HEALTHCARE MATERIALS, Vol. 3.
author keywords: immune response; immunomodulation; macrophage; tissue engineering; tissue-engineered vascular grafts
MeSH headings : Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Humans; Immunity; Immunomodulation; Tissue Engineering
TL;DR:
In this review, the basic concepts of vascular tissue engineering and immunoengineering are considered, the state‐of‐art of TEVGs is summarized and the role of macrophages in TEVG regeneration is analyzed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 31, 2022
2021 journal article
A hybrid vascular graft harnessing the superior mechanical properties of synthetic fibers and the biological performance of collagen filaments
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 118.
Contributors: n , T. Bambharoliya n , Y. Xie n, L. Liu *, H. Celik *, L. Wang *, O. Akkus *, M. King n
author keywords: Tissue-engineered vascular graft; Biomaterial; Hybrid; Electrochemically aligned collagen; Poly (lactic acid)
MeSH headings : Biocompatible Materials / pharmacology; Blood Vessel Prosthesis; Collagen; Endothelial Cells; Tissue Engineering; Tissue Scaffolds
TL;DR:
A hybrid tubular vascular tissue engineered scaffold has been circular-knitted using novel electrochemically aligned collagen (ELAC) filaments plied together with traditional poly(lactic acid) (PLA) yarn, which shows excellent mechanical and biological performance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 19, 2021
2020 journal article
Biodegradable Polymers as the Pivotal Player in the Design of Tissue Engineering Scaffolds
Advanced Healthcare Materials, 5, 1901358.
author keywords: biodegradable materials; biomaterials; composites; polymers; tissue engineering scaffolds
MeSH headings : Biocompatible Materials; Polymers; Regenerative Medicine; Tissue Engineering; Tissue Scaffolds
TL;DR:
The interaction between implanted biodegradable biomaterials and the in vivo environment are discussed, including the properties and functional changes of the degradable scaffold, the local effect of degradation on the contiguous tissue and their evaluation using both in vitro and in vivo models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 19, 2020
2020 book
Coronary Artery Disease and The Evolution of Angioplasty Devices
In SpringerBriefs in Materials.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 27, 2020
2019 journal article
Application of Cognitive Task Performance Modeling for Assessing Usability of Transradial Prostheses
IEEE TRANSACTIONS ON HUMAN-MACHINE SYSTEMS, 49(4), 381–387.
Contributors: M. Zahabi*, M. White *, W. Zhang n, A. Winslow n, n , H. Huang n , D. Kaber*
author keywords: Cognitive modeling; GOMSL; mental workload; prosthetics
TL;DR:
Investigating the use of cognitive modeling to assess the usability of an upper-limb prosthesis with a focus on mental workload responses revealed the PR mode to be more intuitive, reduce cognitive load, and increase efficiency in prosthetic control as compared to the DC mode.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 12, 2019
2019 journal article
Engineering small-caliber vascular grafts from collagen filaments and nanofibers with comparable mechanical properties to native vessels
BIOFABRICATION, 11(3).
author keywords: small caliber vascular graft; endothelialization; knitting; electrospinning; electrochemically aligned collagen (ELAC) filament; collagen nanofibers; mechanical properties
MeSH headings : Animals; Biomechanical Phenomena; Blood Vessel Prosthesis; Blood Vessels / physiology; Cell Adhesion / drug effects; Cell Proliferation / drug effects; Collagen / pharmacology; Mice; Nanofibers / chemistry; Polyesters / chemistry; Rats; Sutures; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The feasibility of the use of novel collagen filaments for fabricating small caliber tissue-engineered vascular grafts that provide both sufficient mechanical properties and superior biological performance is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 4, 2019
2019 chapter
Structural Design, Fabrication and Evaluation of Resorbable Fiber-Based Tissue Engineering Scaffolds
In & L. Q. Z. (E. In E. Jacob-Lopes (Ed.), Biotechnology and Bioengineering.
Ed(s): &. In E. Jacob-Lopes
TL;DR:
This chapter will explain the unique advantages of using textile technologies for tissue engineering scaffold fabrication, and will delineate the differences in design, fabrication and performance of woven, warp and weft knitted, braided, nonwoven and electrospun scaffolds.
(via Semantic Scholar)
www.intechopen.com (publisher PDF)
Source: ORCID
Added: February 16, 2020
Employment
Updated: October 20th, 2023 17:45
2022 - present
University of Washington Seattle, WA, US
Postdoctoral Scholar
Bioengineering
2018 - present
North Carolina State University Raleigh, NC, US
Research Assistant
Wilson College of Textiles
2018 - 2021
North Carolina State University Raleigh, NC, US
Teaching Assistant
UNC/NCSU Joint Department of Biomedical Engineering
2021 - 2021
North Carolina State University Analytical Instrumentation Facility Raleigh, North Carolina, US
Laboratory assistant
Bio Sample Preparation Lab
2019 - 2019
Novozymes Franklinton, North Carolina, US
R&D Intern
Research and Development
Education
Updated: July 31st, 2022 00:14
2018 - 2022
North Carolina State University Raleigh, North Carolina, US
PhD
Wilson College of Textiles, Fiber and Polymer Science
Funding History
Funding history based on the linked ORCID record. Updated: July 4th, 2021 17:44
grant
January 1 - December 1, 2021
Textile-Reinforced Composite Vascular Graft for Cardiac Patients
AATCC Foundation
award
December 1, 2020
A Spatiotemporally Controlled Multi-Factor Releasing Composite Scaffold for Vascular Tissue Engineering
Society for Biomaterials
grant
March 1 - December 1, 2020
WBC 2020 - 11th World Biomaterials Congress
Ellen Rohde Women’s Leadership Initiative
grant
January 1 - December 1, 2020
A hybrid vascular graft harnessing the superior mechanical properties of synthetic fibers and the bioactivity of collagen yarns
AATCC Foundation
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