@article{zhao_sun_xue_wang_king_yu_jiao_sun_wang_2021, title={Development of a polycaprolactone/poly(p-dioxanone) bioresorbable stent with mechanically self-reinforced structure for congenital heart disease treatment}, volume={6}, ISSN={["2452-199X"]}, url={https://doi.org/10.1016/j.bioactmat.2021.02.017}, DOI={10.1016/j.bioactmat.2021.02.017}, abstractNote={Recent progress in bioresorbable stents (BRSs) has provided a promising alternative for treating coronary artery disease. However, there is still lack of BRSs with satisfied compression and degradation performance for pediatric patients with congenital heart disease, leading to suboptimal therapy effects. Here, we developed a mechanically self-reinforced composite bioresorbable stent (cBRS) for congenital heart disease application. The cBRS consisted of poly(p-dioxanone) monofilaments and polycaprolactone/poly(p-dioxanone) core-shell composite yarns. Interlacing points in cBRS structure were partially bonded, offering the cBRS with significantly higher compression force compared to typical braids and remained good compliance. The suitable degradation profile of the cBRS can possibly preserve vascular remodeling and healing process. In addition, the controllable structural organization provides a method to customize the performance of the cBRS by altering the proportion of different components in the braids. The in vivo results suggested the cBRS supported the vessel wall similar to that of metallic stent. In both abdominal aorta and iliac artery of porcine, cBRS was entirely endothelialized within 1 month and maintained target vessels with good patency in the 12-month follow-up. The in vivo degradation profile of the cBRS is consistent with static degradation results in vitro. It is also demonstrated that there is minimal impact of pulsatile pressure of blood flow and variation of radial force on the degradation rate of the cBRS. Moreover, the lumen of cBRS implanted vessels were enlarged after 6 months, and significantly larger than the vessels implanted with metallic stent in 12 months.}, number={9}, journal={BIOACTIVE MATERIALS}, author={Zhao, Fan and Sun, Jing and Xue, Wen and Wang, Fujun and King, Martin W. and Yu, Chenglong and Jiao, Yongjie and Sun, Kun and Wang, Lu}, year={2021}, month={Sep}, pages={2969–2982} }
 @article{zhao_wang_king_wang_2019, title={Effect of dynamic and static loading during in vitro degradation of a braided composite bioresorbable cardiovascular stent}, volume={250}, ISSN={["1873-4979"]}, DOI={10.1016/j.matlet.2019.04.097}, abstractNote={Bioresorbable cardiovascular stents are usually subjected to dynamic mechanical loads in vivo, which results in a different degradation profile compared to that measured under a static in vitro immersion test. In this study, a dynamic test platform was used to mimic cyclic pulsatile pressure and compared the changes in polymer properties of poly(p-dioxaone)/polycaprolane (PPDO/PCL) braided composite bioresorbable stents (BCBRSs) with static loading and non-loaded environments. The results showed static compressive load accelerated the changes in the hydrolysis process and crystallinity for polymers while the pulsatile pressure increased surface corrosion of the stent struts. Moreover, the degradation rate under dynamic loading was attenuated due to the mitigation of viscous flow of molecule chains and autocatalysis process, compared with that under static loading and non-loaded conditions.}, journal={MATERIALS LETTERS}, author={Zhao, Fan and Wang, Fujun and King, Martin W. and Wang, Lu}, year={2019}, month={Sep}, pages={12–15} }