2019 journal article

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin


By: E. Quist*, G. Boorman*, J. Cullen n, R. Maronpot, A. Remick*, J. Swenberg*, L. Freshwater, J. Hardisty*

author keywords: permethrin; liver neoplasms; hepatocellular adenoma; hepatocellular carcinoma; Pathology Working Group
MeSH headings : Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens / toxicity; Dose-Response Relationship, Drug; Female; Liver Neoplasms / chemically induced; Liver Neoplasms / pathology; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / pathology; Male; Mice, Inbred Strains; Permethrin / toxicity; Sex Factors
TL;DR: An expert panel of pathologists was convened as a Pathology Working Group (PWG) to review coded liver histology sections from male and female mice and to classify all liver neoplasms according to current nomenclature and diagnostic criteria guidelines, which indicate that permethrin induced a significant dose-dependent increase in the incidence of hepatocellular neoplasm in treated female mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: February 11, 2019

1999 chapter

Lung, pleura and mediastinum

In Pathology of the mouse: reference and atlas (1st ed.). Vienna, IL: Cache River Press.

By: D. Dixon, R. Herbert, R. Sills & G. Boorman

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Predominant p53 G -> A transition mutation and enhanced cell proliferation in uterine sarcomas of CBA mice treated with 1,2-dimethylhydrazine


By: L. Trukhanova*, H. Hong*, R. Sills*, A. Bowser*, B. Gaul*, G. Boorman*, V. Turusov*, T. Devereux*, D. Dixon*

author keywords: tumor suppressor gene; ras proto-oncogene; malignant fibrous histiocytoma; stromal sarcoma; undifferentiated sarcoma; estrogen receptor; desmin
MeSH headings : 1,2-Dimethylhydrazine; Animals; Cell Division; Desmin / analysis; Female; Genes, p53 / genetics; Immunohistochemistry; Mice; Mice, Inbred CBA; Point Mutation; Polymorphism, Single-Stranded Conformational; Proliferating Cell Nuclear Antigen / analysis; Receptors, Estrogen / analysis; Sarcoma, Experimental / chemistry; Sarcoma, Experimental / genetics; Sarcoma, Experimental / pathology; Tumor Suppressor Protein p53 / analysis; Uterine Neoplasms / chemically induced; Uterine Neoplasms / chemistry; Uterine Neoplasms / genetics; Uterine Neoplasms / pathology
TL;DR: The data suggest that DMH-induced uterine sarcomas are not consistent with smooth muscle cell origin and that a subset of these tumors, specifically DMh-induced malignant fibrous histiocytomas, have unique p 53 G:C→A:T transitions and a high proliferative rate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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