Works (196)

Updated: March 2nd, 2024 06:20

2023 book edited

Everyday Chemicals

By: G. LeBlanc*

Sources: Crossref, ORCID
Added: November 8, 2023

2022 journal article

Ignored microplastic sources from plastic bottle recycling

SCIENCE OF THE TOTAL ENVIRONMENT, 838.

By: Y. Guo*, X. Xia*, J. Ruan*, Y. Wang*, J. Zhang*, G. LeBlanc n, L. An*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Post-consumer PET bottles; PET flake; Microplastics; Wet crush; Recycling
MeSH headings : Environmental Monitoring; Microplastics; Plastics; Polyethylene Terephthalates; Sewage; Wastewater / analysis; Water Pollutants, Chemical / analysis
Sources: Web Of Science, ORCID
Added: June 20, 2022

2022 journal article

Organotins in a food web from the Three Gorges Reservoir, China: Trophic enrichment and potential health risk

SCIENCE OF THE TOTAL ENVIRONMENT, 845.

By: J. You*, J. Gao*, P. Fu*, G. LeBlanc n, J. Guo*, L. Zhang*, M. Li*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Organotin; Food web; Bioaccumulation; Trophic enrichment; Health risk
MeSH headings : Animals; China; Environmental Monitoring / methods; Food Chain; Organotin Compounds; Rivers; Water; Water Pollutants, Chemical / analysis
Sources: Web Of Science, ORCID
Added: October 3, 2022

2021 review

A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology

[Review of ]. FRONTIERS IN ENDOCRINOLOGY, 12.

By: T. Knigge*, G. LeBlanc n & A. Ford*

co-author countries: France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: endocrine disruption; neuroendocrine disruption; ecdysteroid signaling; color change; sexual differentiation
MeSH headings : Animals; Biological Evolution; Crustacea / classification; Crustacea / drug effects; Crustacea / genetics; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Endocrine System / embryology; Endocrine System / growth & development; Fishes / classification; Molting / drug effects; Molting / physiology; Reproduction / drug effects; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID
Added: April 5, 2021

2021 journal article

A proposed nomenclature for microplastic contaminants

MARINE POLLUTION BULLETIN, 172.

By: W. Shi*, T. Cui*, H. Wu*, G. LeBlanc n, F. Wang* & L. An*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Plastic particles; Particle size; Salt solution; Density; Standard format
MeSH headings : Environmental Monitoring; Microplastics; Plastics; Research Design; Water Pollutants, Chemical / analysis
Sources: Web Of Science, ORCID
Added: November 8, 2021

2020 journal article

An effective method for evaluation of microplastic contaminant in gastropod from Taihu Lake, China

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 27(18), 22878–22887.

By: Q. Xu*, T. Deng*, G. LeBlanc n & L. An*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Polymer; Microplastics; mu-FT-IR; Gastropod; Digestion
MeSH headings : Animals; China; Environmental Monitoring; Lakes; Microplastics; Plastics; Water Pollutants, Chemical / analysis
Sources: Web Of Science, ORCID
Added: May 8, 2020

2020 journal article

Endocrine Disruption in Invertebrates: A Survey of Research Progress

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(21), 13365–13369.

By: A. Ford* & G. LeBlanc n

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Animals; Ecosystem; Endocrine Disruptors / analysis; Endocrine Disruptors / toxicity; Endocrine System; Invertebrates; Surveys and Questionnaires; Vertebrates
Sources: Web Of Science, ORCID
Added: February 1, 2021

2020 journal article

Investigation of the microplastics profile in sludge from China's largest Water reclamation plant using a feasible isolation device

JOURNAL OF HAZARDOUS MATERIALS, 388.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Sewage sludge; Isolation device; Source; Risk; Solutions
Sources: Web Of Science, ORCID
Added: May 26, 2020

2020 journal article

Involvement of glutamate and serotonin transmitter systems in male sex determination in Daphnia pulex

JOURNAL OF INSECT PHYSIOLOGY, 121.

By: A. Camp n, J. Yun n, S. Chambers n, M. Haeba n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: Environmental sex determination; Endocrine cascade; Juvenile hormones; Zooplankton; Abiotic stimuli; N-methyl-D-aspartate receptor
MeSH headings : Animals; Daphnia / genetics; Daphnia / metabolism; Daphnia / physiology; Environment; Gene Expression; Glutamic Acid / genetics; Glutamic Acid / metabolism; Male; Neurotransmitter Agents / genetics; Neurotransmitter Agents / metabolism; Receptors, N-Methyl-D-Aspartate / agonists; Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate / metabolism; Seasons; Serotonin / genetics; Serotonin / metabolism; Sex Determination Processes / genetics; Sex Determination Processes / physiology; Signal Transduction
Sources: Web Of Science, ORCID
Added: March 30, 2020

2020 journal article

Phthalate Esters and Their Potential Risk in PET Bottled Water Stored under Common Conditions

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 17(1).

By: X. Xu*, G. Zhou*, K. Lei*, G. LeBlanc n & L. An*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: PET bottles; contained water; PAEs; migration; health risk
MeSH headings : Beijing; Drinking Water / analysis; Endocrine Disruptors / toxicity; Esters / analysis; Esters / toxicity; Phthalic Acids / toxicity; Polyethylene Terephthalates / analysis; Polyethylene Terephthalates / toxicity
Sources: Web Of Science, ORCID
Added: April 20, 2020

2019 weblog post

Being certain about uncertainty

Le Blanc, G. A. (2019, July 2). https://news.ncsu.edu/2019/07/being-certain-about-uncertainty/

By: G. Le Blanc

Source: NC State University Libraries
Added: October 30, 2020

2019 journal article

Complementary roles of photoperiod and temperature in environmental sex determination in Daphnia spp.

The Journal of Experimental Biology, 222(4), jeb195289.

By: A. Camp n, M. Haeba n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: Zooplankton; Endocrine cascade; Methyl farnesoate receptor; Juvenoids; Methyl farnesoate
MeSH headings : Animals; Arthropod Proteins / genetics; Arthropod Proteins / metabolism; Daphnia / genetics; Daphnia / growth & development; Gene Expression Profiling; Gene Expression Regulation; Hot Temperature; Male; Photoperiod; Sex Determination Processes; Signal Transduction; Species Specificity
Sources: Web Of Science, ORCID, Crossref
Added: March 18, 2019

2019 journal article

Freshwater snail Parafossarulus striatulus estrogen receptor: Characteristics and expression profiles under lab and field exposure

CHEMOSPHERE, 220, 611–619.

By: F. Ma*, X. Han*, L. An*, K. Lei*, H. Qi* & G. LeBlanc n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Freshwater snail; Endocrine disrupting chemicals; Mode of action; Estrogen receptor orthologue; RACE
MeSH headings : Animals; China; DNA, Complementary; Endocrine Disruptors / toxicity; Estradiol / pharmacology; Female; Lakes; Male; Methyltestosterone / pharmacology; Mollusca / chemistry; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Snails / chemistry; Transcription, Genetic; Transcriptome; Vitellogenins / genetics
Sources: Web Of Science, ORCID
Added: March 4, 2019

2019 journal article

The role of nuclear receptor E75 in regulating the molt cycle of Daphnia magna and consequences of its disruption

PLOS ONE, 14(8), e0221642.

By: S. Street n, S. Eytcheson n & G. LeBlanc n

co-author countries: United States of America 🇺🇸

Ed(s): C. Englert

MeSH headings : Animals; Daphnia / drug effects; Daphnia / metabolism; Daphnia / physiology; Gene Expression Regulation, Developmental / drug effects; Models, Biological; Molting / drug effects; Molting / genetics; Molting / physiology; Nitroprusside / pharmacology; RNA Interference; RNA, Double-Stranded / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear / metabolism; Signal Transduction / drug effects
Sources: Crossref, ORCID
Added: September 28, 2019

2018 journal article

Hemoglobin Levels Modulate Nitrite Toxicity to Daphnia magna

Scientific Reports, 8(1).

By: S. Eytcheson n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Copper / toxicity; Daphnia / drug effects; Daphnia / genetics; Hemoglobins / genetics; Hemoglobins / metabolism; Nitrates / metabolism; Nitrates / toxicity; Nitrites / metabolism; Nitrites / toxicity; Pyridines / pharmacology; Pyridines / toxicity; RNA, Small Interfering / genetics; Reproduction / drug effects; Reproduction / genetics; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2018 magazine article

New method lights the way for future toxicity testing

Le Blanc, G. A. (2018, January). Euro Cosmetics, (26).

By: G. Le Blanc

Source: NC State University Libraries
Added: October 30, 2020

2018 journal article

No impacts of microcystins on wild freshwater snail Bellamya Aeruginosa fecundity from a eutrophic lake

Environmental Toxicology and Pharmacology, 60, 165–168.

By: F. Qiao*, K. Lei*, X. Han*, Z. Wei*, X. Zhao*, L. An*, G. LeBlanc n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Eutrophication; Microcystin; Freshwater snail; Fecundity
MeSH headings : Animals; Eutrophication; Fertility / drug effects; Lakes; Microcystins / toxicity; Snails / drug effects; Snails / physiology; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Agonist-mediated assembly of the crustacean methyl farnesoate receptor

Scientific Reports, 7(1).

By: E. Kakaley n, H. Wang n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Crustacea; Fatty Acids, Unsaturated / metabolism; Gene Expression; Models, Biological; Nuclear Receptor Coactivators / chemistry; Nuclear Receptor Coactivators / genetics; Nuclear Receptor Coactivators / metabolism; Protein Binding; Protein Multimerization; Protein Subunits / agonists; Protein Subunits / chemistry; Protein Subunits / genetics
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Ligand-Mediated Receptor Assembly as an End Point for High-Throughput Chemical Toxicity Screening

Environmental Science & Technology, 51(16), 9327–9333.

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Daphnia; Energy Transfer; Genes, Reporter; Ligands; Reproduction; Toxicity Tests; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Preliminary evidence for snail deformation from a Eutrophic lake

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 53, 219–226.

By: K. Lei*, F. Qiao*, Q. Liu*, Z. Wei*, L. An*, H. Qi*, S. Cui*, G. LeBlanc n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Eutrophication; Snail; Deformity; Transcriptomic; Mechanism
MeSH headings : Animals; China; Chlorophyll / analysis; Chlorophyll A; Congenital Abnormalities; Eutrophication; Female; Gene Expression Profiling; Lakes / chemistry; Snails / anatomy & histology; Snails / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 weblog post

The value of science is reflected in your everyday decisions

Le Blanc, G. A. (2017, March 31). https://news.ncsu.edu/2017/03/the-value-of-science-leblanc-2017/

By: G. Le Blanc

Source: NC State University Libraries
Added: October 30, 2020

2017 journal article

Validation of a two-generational reproduction test in Daphnia magna: An interlaboratory exercise

Science of The Total Environment, 579, 1073–1083.

By: C. Barata*, B. Campos*, C. Rivetti*, G. LeBlanc n, S. Eytcheson n, S. McKnight n, M. Tobor-Kaplon*, S. de Vries Buitenweg* ...

co-author countries: Spain 🇪🇸 France 🇫🇷 Japan 🇯🇵 Korea (Republic of) 🇰🇷 Mexico 🇲🇽 Netherlands 🇳🇱 Russian Federation 🇷🇺 United States of America 🇺🇸
author keywords: Daphnia reproduction; Multigeneration assay; Interlaboratory; OECD 211; Contaminants; Life-history; Offspring quality
MeSH headings : Animals; Daphnia / physiology; Fertility; Reproduction / drug effects; Toxicity Tests / methods; Water Pollutants, Chemical / toxicity
Source: Crossref
Added: January 28, 2020

2017 journal article

Validation of a two-generational reproduction test in Daphnia magna: an interlaboratory exercise

Science of the Total Environment, 579, 1073–1083.

By: C. Barata, B. Campos, C. Rivetti, G. LeBlanc, S. Eytcheson, S. McKnight, M. Tobor-Kaplon, S. Buitenweg ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Differential Interactions of the Flame Retardant Triphenyl Phosphate within the PPAR Signaling Network

MOJ Toxicology, 2(3).

By: G. Le Blanc

Sources: Crossref, ORCID
Added: September 28, 2019

2016 journal article

Retrospective: Acute Toxicity of Priority Pollutants

Bulletin of Environmental Contamination and Toxicology, 97(3), 301–302.

By: G. LeBlanc n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 content posted

Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing

By: V. Wilson*, G. LeBlanc n, S. Kullman n, K. Crofton*, P. Schmieder* & M. Jacobs*

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Sources: Crossref, ORCID
Added: November 11, 2019

2015 journal article

Estimation of time-varying mortality rates using continuous models for Daphnia magna

APPLIED MATHEMATICS LETTERS, 44, 12–16.

By: K. Adoteye n, H. Banks n, K. Flores n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: Structured population model; Leslie matrix model; Sinko-Streifer model; Daphnia magna; Time-dependent mortality rate
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 review

Males on demand: the environmental-neuro-endocrine control of male sex determination in daphnids

[Review of ]. FEBS JOURNAL, 282(21), 4080–4093.

By: G. LeBlanc n & E. Medlock n

co-author countries: United States of America 🇺🇸
author keywords: doublesex; epigenetic; farnesoic acid O-methyltransferase; NMDA receptor; nutrition; parthenogenesis; photoperiod; sex lethal; temperature; transformer
MeSH headings : Animals; Daphnia / genetics; Daphnia / growth & development; Daphnia / physiology; Environment; Fatty Acids, Unsaturated / physiology; Female; Food; Male; Models, Biological; Neurosecretory Systems / physiology; Parthenogenesis / genetics; Parthenogenesis / physiology; Phenotype; Population Density; Seasons; Sex Determination Processes / genetics; Sex Determination Processes / physiology; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Short-term fish reproduction assays with methyl tertiary butyl ether with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity

Environmental Toxicology and Chemistry, 34(9), 2013–2022.

By: E. Mihaich, S. Erler*, G. Le Blanc n & S. Gallagher

co-author countries: United States of America 🇺🇸
author keywords: Methy-tert-butyl ether (MTBE); Endocrine disruptor; Fish short-term reproduction assay; Aquatic toxicology
MeSH headings : Animals; Cyprinidae / growth & development; Cyprinidae / physiology; Endocrine System / drug effects; Endocrine System / metabolism; Enzyme-Linked Immunosorbent Assay; Female; Fertility; Male; Methyl Ethers / chemistry; Methyl Ethers / toxicity; Reproduction / drug effects; Vitellogenins / blood; Water Pollutants, Chemical / chemistry; Water Pollutants, Chemical / toxicity; Zebrafish / growth & development; Zebrafish / physiology
Sources: Crossref, ORCID
Added: November 17, 2019

2015 journal article

Statistical validation of structured population models for Daphnia magna

Mathematical Biosciences, 266, 73–84.

By: K. Adoteye n, H. Banks n, K. Cross n, S. Eytcheson n, K. Flores n, G. LeBlanc n, T. Nguyen n, C. Ross n ...

co-author countries: United States of America 🇺🇸
author keywords: Sensitivity analysis; Structured population model; Uncertainty quantification; Density-dependence; Multi-scale data; Daphnia magna
MeSH headings : Animals; Daphnia; Models, Statistical; Population Dynamics
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Endocrine regulation of predator-induced phenotypic plasticity

Oecologia, 176(3), 625–635.

By: S. Dennis*, G. LeBlanc n & A. Beckerman*

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Animals; Daphnia / anatomy & histology; Daphnia / genetics; Daphnia / growth & development; Daphnia / physiology; Ecdysone / metabolism; Endocrine System / metabolism; Food Chain; Gene Expression Regulation; Juvenile Hormones / metabolism; Phenotype; Real-Time Polymerase Chain Reaction
Sources: NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Estrogen alters the profile of the transcriptome in river snail Bellamya aeruginosa

Ecotoxicology, 24(2), 330–338.

By: K. Lei*, R. Liu*, L. An*, Y. Luo* & G. LeBlanc n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Bellamya aeruginosa; Transcriptome; 454 sequencing; GO; Estrogen
MeSH headings : Animals; Estradiol / toxicity; Estrogens / toxicity; Molecular Sequence Data; Snails / drug effects; Snails / genetics; Transcriptome / drug effects; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2013 journal article

A Transgenerational Endocrine Signaling Pathway in Crustacea

PLoS ONE, 8(4), e61715.

By: G. LeBlanc n, Y. Wang n, C. Holmes n, G. Kwon n & E. Medlock n

co-author countries: United States of America 🇺🇸

Ed(s): B. He

MeSH headings : Amino Acid Sequence; Animals; Cloning, Molecular; Crustacea / drug effects; Crustacea / metabolism; Daphnia / drug effects; Daphnia / physiology; Endocrine System / drug effects; Endocrine System / metabolism; Fatty Acids, Unsaturated / pharmacology; Female; Fertility; Genes, Reporter; Life Cycle Stages / drug effects; Ligands; Luciferases / metabolism; Male; Molecular Sequence Data; Population Density; Pyridines / pharmacology; Sex Determination Processes / drug effects; Sex Ratio; Signal Transduction / drug effects; Transcription Factors / chemistry
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2012 report

Detailed review paper on the state of the science on novel in vitro and in vivo screening and testing methods and endpoints for evaluating endocrine disruptors

(Series on Testing & Assessment No. 178). Organization for Economic Co-operation and Development.

By: G. Le Blanc, S. Kullman, D. Norris, W. Baldwin, K. W. & J. Greally

Source: NC State University Libraries
Added: August 8, 2021

2011 journal article

Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna)

AQUATIC TOXICOLOGY, 101(2), 351–357.

By: B. Hannas n, Y. Wang n, S. Thomson n, G. Kwon n, H. Li n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: Vitellogenin; Water flea; Biomarker; Ecdysteroids; Estrogens; Endocrine disruption
MeSH headings : Animals; Cadmium / toxicity; Daphnia / drug effects; Daphnia / genetics; Daphnia / metabolism; Ecdysteroids / toxicity; Ecdysterone / toxicity; Environmental Pollutants / toxicity; Estrogens / toxicity; Gene Expression / drug effects; Heterocyclic Compounds / toxicity; Polycyclic Compounds / toxicity; RNA, Messenger / metabolism; Vitellogenins / genetics; Vitellogenins / metabolism; Xenobiotics / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Tributyltin Synergizes with 20-Hydroxyecdysone to Produce Endocrine Toxicity

TOXICOLOGICAL SCIENCES, 123(1), 71–79.

By: Y. Wang n, G. Kwon n, H. Li n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: chemical mixtures; models; synergy; invertebrate; ecdysteroid; nuclear receptor; retinoid X receptor; ecdysteroid receptor
MeSH headings : Animals; Cells, Cultured; Daphnia; Dose-Response Relationship, Drug; Drug Synergism; Ecdysterone / metabolism; Ecdysterone / toxicity; Female; Gene Expression / drug effects; Molting / drug effects; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Retinoid X Receptors / genetics; Retinoid X Receptors / metabolism; Signal Transduction; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 chapter

Acute Toxicity

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 225–236). Hoboken, NJ: Wiley.

By: G. LeBlanc

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: March 18, 2021

2010 chapter

Elimination of Toxicants

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 213–222). Hoboken, NJ: Wiley.

By: G. Le Blanc

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: March 8, 2021

2010 chapter

Endocrine Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 345–362). Hoboken, NJ: Wiley.

By: G. LeBlanc

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: March 18, 2021

2010 review

Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs

[Review of ]. ECOTOXICOLOGY, 19(1), 4–23.

By: R. Sternberg n, M. Gooding n, A. Hotchkiss n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: Mollusk; Endocrinology; Tributyltin; Imposex; Retinoid X-receptor
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Female; Male; Models, Biological; Photoperiod; Retinoid X Receptors / metabolism; Sex Characteristics; Sex Differentiation / drug effects; Signal Transduction / drug effects; Snails / drug effects; Snails / physiology; Temperature; Tretinoin / metabolism; Trialkyltin Compounds / metabolism; Trialkyltin Compounds / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Expression and ecdysteroid responsiveness of the nuclear receptors HR3 and E75 in the crustacean Daphnia magna

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 315(1-2), 208–218.

By: B. Hannas n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: Nuclear receptor; Water flea; Molting; Ecdysis; Endocrine disruption
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Crustacea / genetics; Crustacea / physiology; Daphnia / genetics; Daphnia / physiology; Drosophila melanogaster / genetics; Ecdysteroids / metabolism; Ecdysterone / metabolism; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Molecular Sequence Data; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Sequence Alignment; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Interactions of the crustacean nuclear receptors HR3 and E75 in the regulation of gene transcription

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 167(2), 268–278.

By: B. Hannas n, Y. Wang n, W. Baldwin*, Y. Li*, A. Wallace n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: Daphnia pulex; Ecdysteroids; Endocrine disruptor; Nuclear receptors
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Intracellular Conversion of Environmental Nitrate and Nitrite to Nitric Oxide with Resulting Developmental Toxicity to the Crustacean Daphnia magna

PLoS ONE, 5(8), e12453.

By: B. Hannas n, P. Das n, H. Li n & G. LeBlanc n

co-author countries: United States of America 🇺🇸

Ed(s): X. Pan

MeSH headings : Animals; Animals, Newborn; Daphnia / cytology; Daphnia / drug effects; Daphnia / growth & development; Daphnia / metabolism; Drosophila / cytology; Drosophila / drug effects; Drosophila / metabolism; Ecdysteroids / metabolism; Ecosystem; Endocrine System / drug effects; Endocrine System / metabolism; Environmental Monitoring; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Female; Intracellular Space / drug effects; Intracellular Space / metabolism; Nitrates / metabolism; Nitrates / toxicity; Nitric Oxide / metabolism; Nitrites / metabolism; Nitrites / toxicity; Reproduction / drug effects; Risk
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2010 chapter

Introduction to Biochemical and Molecular Methods in Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 15–28). Hoboken, NJ: Wiley.

By: E. Hodgson, G. Le Blanc, S. Meyer & R. Smart

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: March 8, 2021

2009 journal article

Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex

BMC Genomics, 10(1), 500.

By: S. Thomson n, W. Baldwin*, Y. Wang n, G. Kwon n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; Daphnia / genetics; Daphnia / physiology; Evolution, Molecular; Female; Gene Expression Regulation; Genome; Humans; Molecular Sequence Data; Parthenogenesis / genetics; Phylogeny; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear / chemistry; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism
Sources: Crossref, ORCID
Added: November 17, 2019

2009 journal article

Interactions of methyl farnesoate and related compounds with a crustacean retinoid X receptor

Molecular and Cellular Endocrinology, 309(1-2), 109–116.

By: Y. Wang n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: RXR; EcR; Methyl farnesoate; Daphnia; Tributyltin
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; DNA, Complementary / genetics; DNA, Complementary / isolation & purification; Daphnia / drug effects; Daphnia / metabolism; Ecdysterone / pharmacology; Fatty Acids, Unsaturated / metabolism; Genes, Reporter; Humans; Ligands; Luciferases / metabolism; Male; Molecular Sequence Data; Open Reading Frames / genetics; Receptors, Steroid / metabolism; Retinoid X Receptors / chemistry; Retinoid X Receptors / genetics; Retinoid X Receptors / metabolism; Sequence Alignment; Sequence Homology, Amino Acid; Sex Determination Processes; Sex Ratio; Transcriptional Activation / drug effects
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

2009 chapter

Overview of Endocrine Disruptor Ecotoxicity in Wildlife

In C. Ethridge & J. Stevens (Eds.), Endocrine Toxicology (3rd ed., pp. 280–312). London: Informa Healthcare.

By: G. LeBlanc

Ed(s): C. Ethridge & J. Stevens

Source: NC State University Libraries
Added: March 18, 2021

2009 journal article

Predictive Modeling of a Mixture of Thyroid Hormone Disrupting Chemicals That Affect Production and Clearance of Thyroxine

INTERNATIONAL JOURNAL OF TOXICOLOGY, 28(5), 368–381.

By: J. Flippin n, J. Hedge n, M. DeVito n, G. LeBlanc n & K. Crofton n

co-author countries: United States of America 🇺🇸
author keywords: thyroid hormone disruption; mixture modeling; pronamide; mancozeb; thiram; polyhalogenated aromatic hydrocarbons
MeSH headings : Animals; Cytochrome P-450 CYP1A1 / metabolism; Cytochrome P-450 CYP2B1 / metabolism; Dose-Response Relationship, Drug; Endocrine Disruptors / chemistry; Endocrine Disruptors / toxicity; Female; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Models, Biological; Pesticides / chemistry; Pesticides / toxicity; Predictive Value of Tests; Rats; Rats, Long-Evans; Thyroid Gland / drug effects; Thyroid Gland / metabolism; Thyroxine / biosynthesis; Thyroxine / blood; Thyroxine / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Environmental cues trigger seasonal regression of primary and accessory sex organs of the mud snail, Ilyanassa obsoleta

JOURNAL OF MOLLUSCAN STUDIES, 74, 301–303.

By: A. Hotchkiss*, R. Sternberg* & G. LeBlanc*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 chapter

Immunochemical Techniques in Toxicology

In E. Hodgson & R. C. Smart (Eds.), Molecular and Biochemical Toxicology (4th ed., pp. 109–128). Hoboken, New Jersey: John Wiley & Sons.

By: G. LeBlanc

Ed(s): E. Hodgson & R. Smart

Source: NC State University Libraries
Added: March 18, 2021

2008 journal article

Synchronized expression of retinoid X receptor mRNA with reproductive tract recrudescence in an imposex-susceptible mollusc

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 42(4), 1345–1351.

By: R. Sternberg n, A. Hotchkiss n & G. Leblanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; Female; Male; Molecular Sequence Data; Mollusca / anatomy & histology; Phylogeny; RNA, Messenger / genetics; Reproduction; Retinoid X Receptors / chemistry; Retinoid X Receptors / genetics; Sequence Homology, Amino Acid; Species Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

The contribution of steroidal androgens and estrogens to reproductive maturation of the eastern mud snail Ilyanassa obsoleta

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 156(1), 15–26.

By: R. Sternberg*, A. Hotchkiss* & G. LeBlanc*

author keywords: androgens; estrogens; retinoids; neogastropod; gastropod; imposex; tributyltin; bisphenol A
MeSH headings : Amino Acid Sequence; Androgens / physiology; Animals; Estradiol / metabolism; Estrogens / physiology; Female; Male; Molecular Sequence Data; Phylogeny; RNA, Messenger / metabolism; Receptors, Androgen / metabolism; Receptors, Estrogen / analysis; Receptors, Estrogen / metabolism; Reproduction / physiology; Sexual Maturation / physiology; Snails / physiology; Testosterone / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 review

An ecological assessment of bisphenol-A: Evidence from comparative biology

[Review of ]. REPRODUCTIVE TOXICOLOGY, 24(2), 225–239.

By: D. Crain*, M. Eriksen, T. Iguchi, S. Jobling*, H. Laufer*, G. LeBlanc n, L. Guillette*

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: bisphenol-A (BPA); wildlife; reproduction; environmental concentrations; vitellogenin; landfill leachate; spermatogenesis
MeSH headings : Animals; Benzhydryl Compounds; Ecology; Environmental Exposure / analysis; Environmental Monitoring / methods; Female; Humans; Male; Phenols / chemistry; Phenols / metabolism; Phenols / toxicity; Reproduction / drug effects; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure

Reproductive Toxicology, 24(2), 131–138.

By: F. vom Saal*, B. Akingbemi*, S. Belcher*, L. Birnbaum*, D. Crain*, M. Eriksen, F. Farabollini*, L. Guillette* ...

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 Japan 🇯🇵 United States of America 🇺🇸

Contributors: F. Saal*, B. Akingbemi*, S. Belcher*, L. Birnbaum*, D. Crain*, M. Eriksen, F. Farabollini*, L. Guillette Jr. ...

author keywords: bisphenol A; in vitro; in vivo; rat; mouse; aquatic animal; cancer; low dose; non-monotonic dose-response curves; developmental programming
MeSH headings : Air Pollutants, Occupational / poisoning; Animals; Animals, Wild; Benzhydryl Compounds; Consensus; Dose-Response Relationship, Drug; Estrogens, Non-Steroidal / poisoning; Female; Humans; Male; Models, Animal; National Institutes of Health (U.S.); North Carolina; Phenols / poisoning; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment / methods; Risk Assessment / standards; United States; United States Environmental Protection Agency
Sources: Crossref, ORCID
Added: March 8, 2020

2007 personal communication

Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure

Gerald LeBlanc; John G. Vandenbergh

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Cloning and characterization of the retinoid X receptor from a primitive crustacean Daphnia magna

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 150(2), 309–318.

By: Y. Wang n, G. Wang n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: crustacean; Daphnia; RXR; hormone; receptor; endocrine; sex determination
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA, Complementary / genetics; Daphnia / genetics; Daphnia / metabolism; Ecdysterone / pharmacology; Fatty Acids, Unsaturated / metabolism; Female; Gene Expression Regulation, Developmental / drug effects; Male; Molecular Sequence Data; Phylogeny; Pyridines / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Retinoid X Receptors / antagonists & inhibitors; Retinoid X Receptors / biosynthesis; Retinoid X Receptors / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 review

Crustacean endocrine toxicology: a review

[Review of ]. ECOTOXICOLOGY, 16(1), 61–81.

By: G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: crustacean; endocrine; ecdysteroid; terpenoid; methyl farnesoate; intersex
MeSH headings : Animals; Crustacea / drug effects; Crustacea / physiology; Endocrine Disruptors / toxicity; Invertebrate Hormones / physiology; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat

TOXICOLOGICAL SCIENCES, 97(1), 65–74.

By: C. Blystone n, J. Furr*, C. Lambright*, K. Howdeshell*, B. Ryan*, V. Wilson*, G. LeBlanc n, L. Gray*

co-author countries: United States of America 🇺🇸
author keywords: prochloraz; testosterone; antiandrogen; puberty; Hershberger; steroidgenesis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; Androgen Antagonists / toxicity; Androgen Receptor Antagonists; Androgens / metabolism; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors / toxicity; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / enzymology; Genitalia, Male / growth & development; Genitalia, Male / metabolism; Imidazoles / toxicity; Male; No-Observed-Adverse-Effect Level; Orchiectomy; Organ Size / drug effects; Progesterone / blood; Rats; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Sexual Development / drug effects; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / metabolism; Testosterone / blood; Testosterone / metabolism; Testosterone Propionate / pharmacology; Time Factors; Toxicity Tests / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition

TOXICOLOGICAL SCIENCES, 97(2), 512–519.

By: C. Blystone n, C. Lambright*, K. Howdeshell*, J. Furr*, R. Sternberg n, B. Butterworth*, E. Durhan*, E. Makynen* ...

co-author countries: United States of America 🇺🇸
author keywords: prochloraz; testosterone; CYP17; steroidogenesis; fetal testis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; 17-alpha-Hydroxyprogesterone / metabolism; Amniotic Fluid / metabolism; Androgen Receptor Antagonists; Androstenedione / blood; Androstenedione / metabolism; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Estradiol / biosynthesis; Estradiol / blood; Female; Fetus / drug effects; Fetus / metabolism; Fungicides, Industrial / pharmacokinetics; Fungicides, Industrial / toxicity; Gene Expression / drug effects; Imidazoles / pharmacokinetics; Imidazoles / toxicity; Male; Phosphoproteins / biosynthesis; Pregnancy; Progesterone / biosynthesis; Progesterone / blood; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Rats; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / biosynthesis; Steroid 17-alpha-Hydroxylase / genetics; Steroids / biosynthesis; Testis / drug effects; Testis / embryology; Testis / metabolism; Testosterone / biosynthesis; Testosterone / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 personal communication

Testosterone and male fertility in red deer

By: G. LeBlanc

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

The environmental-endocrine basis of gynandromorphism (intersex) in a crustacean

International Journal of Biological Sciences, 3(2), 77–84.

By: A. Olmstead & G. LeBlanc*

MeSH headings : Animals; Daphnia / physiology; Disorders of Sex Development / chemically induced; Disorders of Sex Development / epidemiology; Disorders of Sex Development / physiopathology; Environment; Fatty Acids, Unsaturated / metabolism; Female; Incidence; Male; Phenotype; Pyridines; Sex Determination Processes; Temperature
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2006 journal article

A candidate juvenoid hormone receptor cis-element in the Daphnia magna hb2 hemoglobin gene promoter

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 247(1-2), 91–102.

By: T. Gorr*, C. Rider n, H. Wang n, A. Olmstead n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: methyl farnesoate; juvenoid; crustacean; response element; sex determination
MeSH headings : Animals; Base Sequence; Cycloheximide / pharmacology; Daphnia / genetics; Daphnia / physiology; Fatty Acids, Unsaturated / metabolism; Hemoglobins / biosynthesis; Hemoglobins / genetics; Hemoglobins / physiology; Juvenile Hormones / metabolism; Molecular Sequence Data; Promoter Regions, Genetic; Pyridines / metabolism; RNA, Messenger / biosynthesis; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Response Elements; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Atrazine stimulates hemoglobin accumulation in Daphnia magna: Is it hormonal or hypoxic?

TOXICOLOGICAL SCIENCES, 93(2), 443–449.

By: C. Rider n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: cumulative toxicity; terpenoids; mixture modeling; invertebrates; endocrine disruption
MeSH headings : Animals; Atrazine / toxicity; Daphnia / drug effects; Daphnia / metabolism; Dose-Response Relationship, Drug; Hemoglobins / genetics; Hemoglobins / metabolism; Herbicides / toxicity; Hypoxia-Inducible Factor 1 / physiology; Pyridines / toxicity; RNA, Messenger / analysis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 personal communication

Chemical mixtures: Greater-than-additive effects?

By: G. LeBlanc & G. Wang

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Kinetic characterization of the inhibition of acyl coenzyme A: Steroid acyltransferases by tributyltin in the eastern mud snail (Ilyanassa obsoleta)

AQUATIC TOXICOLOGY, 78(3), 233–242.

By: R. Sternberg n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: tributyltin; imposex; acyl coenzyme A; steroid acyltransferase; testosterone; 17 beta-estradiol; endocrine; snail
MeSH headings : Acyltransferases / antagonists & inhibitors; Acyltransferases / drug effects; Acyltransferases / pharmacokinetics; Animals; Esterification / drug effects; Estradiol / metabolism; Female; Kinetics; Microsomes / enzymology; Palmitoyl Coenzyme A / metabolism; Snails / drug effects; Snails / enzymology; Testosterone / metabolism; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

A comparative study on androgen metabolism in three invertebrate species

General and Comparative Endocrinology, 143(3), 211–221.

By: G. Janer, G. LeBlanc & C. Porte

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2005 journal article

A comparative study on androgen metabolism in three invertebrate species

General and Comparative Endocrinology, 143(3), 211–221.

By: G. Janer*, G. LeBlanc n & C. Porte*

co-author countries: Spain 🇪🇸 United States of America 🇺🇸
author keywords: testosterone; androstenedione; metabolism; mollusc; Crustacean; echinoderm
MeSH headings : Amphipoda / physiology; Androstenedione / metabolism; Animals; Biotransformation; Echinodermata / physiology; Female; Male; Sex Characteristics; Snails / physiology; Testosterone / metabolism
Sources: Crossref, ORCID
Added: March 8, 2020

2005 journal article

An integrated addition and interaction model for assessing toxicity of chemical mixtures

TOXICOLOGICAL SCIENCES, 87(2), 520–528.

By: C. Rider n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: synergy; cumulative toxicity; predictive model; toxicodynamic; hazard assessment; risk assessment
MeSH headings : Acetylcholinesterase / metabolism; Algorithms; Animals; Cholinesterase Inhibitors / toxicity; Daphnia / physiology; Dose-Response Relationship, Drug; Drug Interactions; Environmental Pollutants / toxicity; Malathion / toxicity; Models, Biological; Models, Statistical; Parathion / toxicity; Pesticide Synergists / toxicity; Piperonyl Butoxide / toxicity; Toxicity Tests / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 article

Androgen metabolism in invertebrates and its modulation by xenoandrogens - A comparative study

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY, Vol. 1040, pp. 354–356.

By: G. Janer*, G. LeBlanc n & C. Porte*

co-author countries: Spain 🇪🇸 United States of America 🇺🇸
author keywords: androgen; steroid metabolism; organotin; fenarimol; invertebrates
MeSH headings : Androgens / metabolism; Animals; Crustacea / metabolism; Echinodermata / metabolism; Mollusca / metabolism; Species Specificity; Xenobiotics / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Covert signal disruption: Anti-ecdysteroidal activity of bisphenol a involves cross talk between signaling pathways

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 24(1), 146–152.

By: X. Mu n, C. Rider n, G. Hwang n, H. Hoy n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: crustacean; pollutant; reproduction; steroid; terpenoid
MeSH headings : Animals; Benzhydryl Compounds; Daphnia / drug effects; Daphnia / embryology; Daphnia / growth & development; Dose-Response Relationship, Drug; Ecdysteroids / antagonists & inhibitors; Ecdysterone / pharmacology; Juvenile Hormones / physiology; Molting / drug effects; Phenols / antagonists & inhibitors; Phenols / toxicity; Sex Differentiation / drug effects; Signal Transduction / drug effects; Time; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Joint action of polycyclic aromatic hydrocarbons: Predictive modeling of sublethal toxicity

AQUATIC TOXICOLOGY, 75(3), 253–262.

By: A. Olmstead n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: hazard assessment; risk assessment; response addition; synergy; mixture toxicology
MeSH headings : Algorithms; Animals; Daphnia / drug effects; Daphnia / growth & development; Dose-Response Relationship, Drug; Models, Biological; Polycyclic Aromatic Hydrocarbons / toxicity; Toxicology / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Stress signaling: coregulation of hemoglobin and male sex determination through a terpenoid signaling pathway in a crustacean

JOURNAL OF EXPERIMENTAL BIOLOGY, 208(1), 15–23.

By: C. Rider n, T. Gorr*, A. Olmstead n, B. Wasilak n & G. Leblanc n

co-author countries: United States of America 🇺🇸
author keywords: Cladocera; juvenoid; endocrine disruption; evolution; nuclear receptor; Daphnia magna
MeSH headings : Analysis of Variance; Animals; Base Sequence; DNA Primers; Daphnia / physiology; Electrophoresis; Fatty Acids, Unsaturated / pharmacology; Hemoglobins / genetics; Hemoglobins / metabolism; Male; Molecular Sequence Data; Reproduction / physiology; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sex Differentiation / drug effects; Signal Transduction / physiology; Spectrophotometry; Stress, Physiological / metabolism; Terpenes / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Testosterone conjugating activities in invertebrates: are they targets for endocrine disruptors?

AQUATIC TOXICOLOGY, 71(3), 273–282.

By: G. Janer*, R. Sternberg n, G. LeBlanc n & C. Porte*

co-author countries: Spain 🇪🇸 United States of America 🇺🇸
author keywords: sulfotransferase; Acyl-CoA; testosterone acyltransferase; echinoderm; Crustacea; mollusc
MeSH headings : Acyltransferases / metabolism; Analysis of Variance; Animals; Cytosol / metabolism; Invertebrates / drug effects; Invertebrates / enzymology; Italy; Kinetics; Microsomes / metabolism; Organotin Compounds / toxicity; Palmitoyl Coenzyme A / metabolism; Pyrimidines / toxicity; Seawater; Species Specificity; Sulfotransferases / metabolism; Testosterone / metabolism; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 article

Testosterone-fatty acid esterification: A unique target for the endocrine toxicity of tributyltin to gastropods

LeBlanc, G. A., Gooding, M. P., & Sternberg, R. M. (2005, February). INTEGRATIVE AND COMPARATIVE BIOLOGY, Vol. 45, pp. 81–87.

By: G. LeBlanc n, M. Gooding n & R. Sternberg n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

The screening of chemicals for juvenoid-related endocrine activity using the water flea Daphnia magna

AQUATIC TOXICOLOGY, 74(3), 193–204.

By: H. Wang n, A. Olmstead n, H. Li n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: endocrine disruptors; screening; juvenoids; sex determination
MeSH headings : Animals; Benzhydryl Compounds; Daphnia / drug effects; Daphnia / metabolism; Ecdysteroids / metabolism; Ecdysteroids / pharmacology; Endocrine System / drug effects; Endpoint Determination / methods; Fatty Acids, Unsaturated / pharmacology; Female; Juvenile Hormones / agonists; Juvenile Hormones / antagonists & inhibitors; Juvenile Hormones / metabolism; Male; Methoprene / pharmacology; Pesticides / toxicity; Phenols / toxicity; Phytol / pharmacology; Pyridines / pharmacology; Reproducibility of Results; Sex Differentiation / drug effects; Toxicity Tests / methods; Tretinoin / pharmacology; United States; United States Environmental Protection Agency
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Toxicity Assessment of Environmentally Relevant Pollutant Mixtures Using a Heuristic Model

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, 1(2), 114–122.

By: A. Olmstead n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: Mixture toxicology; Mixture model; Daphnid; Insecticides; Pollutants
MeSH headings : Animals; Daphnia; Endpoint Determination; Environmental Pollutants / toxicity; Forecasting; Models, Theoretical; Sensitivity and Specificity; Xenobiotics / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 chapter

Acute Toxicity

In A Textbook of Modern Toxicology (pp. 213–224).

By: G. Leblanc n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 8, 2019

2004 chapter

Basics of Environmental Toxicology

In A Textbook of Modern Toxicology (pp. 463–478).

By: G. Leblanc n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: November 17, 2019

2004 journal article

Cross communication between signaling pathways: Juvenoid hormones modulate ecdysteroid activity in a crustacean

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY, 301A(10), 793–801.

By: X. Mu n & G. Leblanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Proliferation / drug effects; Cells, Cultured; DNA Primers; Daphnia / drug effects; Daphnia / embryology; Daphnia / metabolism; Drosophila; Ecdysteroids / metabolism; Ecdysterone / pharmacology; Embryo, Nonmammalian / drug effects; Fatty Acids, Unsaturated / toxicity; Gene Expression Regulation / drug effects; Juvenile Hormones / antagonists & inhibitors; Juvenile Hormones / toxicity; Models, Biological; Phenylcarbamates / toxicity; Pyridines / toxicity; Pyrimidines / metabolism; RNA, Messenger / metabolism; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Sex Determination Processes; Signal Transduction / physiology; Testosterone / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 chapter

Elimination of Toxicants

In A Textbook of Modern Toxicology (pp. 203–211).

By: G. Leblanc n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 8, 2019

2004 chapter

Endocrine System

In A Textbook of Modern Toxicology (pp. 299–315).

By: G. Leblanc n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: December 8, 2019

2004 personal communication

Evaluating the toxicity of chemical mixtures

LeBlanc, G. A., & Olmstead, A. W. (2004, September).

By: G. LeBlanc* & A. Olmstead*

MeSH headings : Animals; Data Interpretation, Statistical; Drug Interactions; Endocrine System / drug effects; Estrogens / toxicity; Estrogens, Non-Steroidal / toxicity; Female; Rats; Uterus / drug effects; Uterus / growth & development
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Interactive effects of vinclozolin and testosterone propionate on pregnancy and sexual differentiation of the male and female SD Rat

TOXICOLOGICAL SCIENCES, 78(1), 135–143.

By: C. Wolf*, G. LeBlanc & L. Gray

author keywords: sexual differentiation; endocrine-disrupting compounds; cumulative risk; androgen; antiandrogen
MeSH headings : Abnormalities, Drug-Induced / epidemiology; Abnormalities, Drug-Induced / pathology; Androgen Antagonists / pharmacology; Androgen Antagonists / toxicity; Animals; Animals, Newborn; Birth Weight / drug effects; Body Weight / drug effects; Female; Fetal Viability / drug effects; Fetus / metabolism; Genitalia / drug effects; Genitalia / growth & development; Male; Organ Size / drug effects; Oxazoles / antagonists & inhibitors; Oxazoles / pharmacology; Oxazoles / toxicity; Pregnancy; Pregnancy, Animal / drug effects; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sex Differentiation / drug effects; Sexual Maturation / drug effects; Teratogens / toxicity; Testosterone Propionate / antagonists & inhibitors; Testosterone Propionate / metabolism; Testosterone Propionate / pharmacology; Weight Gain / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 chapter

Introduction to Biochemical and Molecular Methods in Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (pp. 13–22).

By: E. Hodgson n, G. Leblanc n, S. Meyer* & R. Smart n

co-author countries: United States of America 🇺🇸

Ed(s): E. Hodgson n

Sources: Crossref, ORCID
Added: December 8, 2019

2004 journal article

Non-target toxicology of a new mosquito larvicide, trypsin modulating oostatic factor

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 80(3), 131–142.

By: D. Thompson n, H. Young n, F. Edens n, A. Olmstead n, G. LeBlanc n, E. Hodgson n, R. Roe n

co-author countries: United States of America 🇺🇸
author keywords: trypsin modulating oostatic factor; TMOF; insecticide; mosquito; mouse; rabbit; duck; water flea
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Seasonal variation in the regulation of testosterone levels in the eastern mud snail (Ilyanassa obsoleta)

Invertebrate Biology, 123(3), 237–243.

By: M. Gooding n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2004 journal article

Synergistic interaction of endocrine-disrupting chemicals: Model development using an ecdysone receptor antagonist and a hormone synthesis inhibitor

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 23(4), 1085–1091.

By: X. Mu n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: endocrine; disruptors; invertebrate; mixtures; synergy
MeSH headings : Algorithms; Animals; Daphnia / growth & development; Daphnia / physiology; Drug Interactions; Ecdysteroids / biosynthesis; Embryonic Development; Endocrine System / drug effects; Environmental Pollutants / toxicity; Fungicides, Industrial / toxicity; Models, Theoretical; Pyrimidines / toxicity; Risk Assessment; Testosterone / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2003 journal article

Insecticidal juvenile hormone analogs stimulate the production of male offspring in the crustacean Daphnia magna

ENVIRONMENTAL HEALTH PERSPECTIVES, 111(7), 919–924.

By: A. Olmstead n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: crustacea; Daphnia; endocrine disruption; invertebrate; methoprene; methyl farnesoate; mixtures; pyriproxyfen
MeSH headings : Animals; Daphnia / physiology; Female; Juvenile Hormones / chemistry; Juvenile Hormones / pharmacology; Male; Sex Ratio
Sources: Web Of Science, ORCID
Added: August 6, 2018

2003 journal article

The biocide tributyltin reduces the accumulation of testosterone as fatty acid esters in the mud snail (Ilyanassa obsoleta)

ENVIRONMENTAL HEALTH PERSPECTIVES, 111(4), 426–430.

By: M. Gooding n, V. Wilson n, L. Folmar n, D. Marcovich n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: acyltransferase; fatty acid esters; Ilyanassa obsoleta; imposex; invertebrate endocrinology; mud snail; testosterone; tributyltin
MeSH headings : Animals; Disorders of Sex Development / chemically induced; Environmental Exposure; Esters; Fatty Acids / metabolism; Female; Male; Snails / physiology; Testosterone / blood; Testosterone / metabolism; Trialkyltin Compounds / adverse effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2003 chapter

The influence of speciation on the toxicity of silver to fathead minnows (Pimephales promelas)

In J. W. Gorsuch, J. R. Kramer, & T. W. LaPoint (Eds.), Silver : environmental transport, fate, effects, and models : papers from Environmental toxicology and chemistry, 1983 to 200 (pp. 313–322). Pensacola, FL: SETAC.

By: G. LeBlanc, J. Mastone, A. Paradice, B. Wilson, H. Lockhart & K. Robillard

Ed(s): J. Gorsuch, J. Kramer & T. LaPoint

Source: NC State University Libraries
Added: March 18, 2021

2002 journal article

Abstracts from the Eleventh International Symposium on Pollutant Responses in Marine Organisms (PRIMO 11) - Endocrine disrupters

Marine Environmental Research, 54(3-5), 741–754.

By: X. Mu, C. Rider & G. Leblanc

Source: NC State University Libraries
Added: August 6, 2018

2002 chapter

Biological Processes

In A. W. Andren & T. W. Bober (Eds.), Silver in the Environment: Transport, Fate and Effects (pp. 65–96). Pensacola, FL: SETAC Press.

By: S. Luoma, C. Hogstrand, R. Bell, G. Bielmyer, F. Galvez, G. LeBlanc, B. Lee, T. Purcell ...

Ed(s): A. Andren & T. Bober

Source: NC State University Libraries
Added: March 26, 2021

2002 journal article

Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 129(2), 127–133.

By: X. Mu n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Crustacea / drug effects; Crustacea / embryology; Crustacea / growth & development; Ecdysteroids / antagonists & inhibitors; Ecdysterone / pharmacology; Embryo, Nonmammalian / drug effects; Gonadal Steroid Hormones / poisoning; Molting / drug effects; Testosterone / poisoning
Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

Effects of prenatal testosterone propionate on the sexual development of male and female rats: A dose-response study

TOXICOLOGICAL SCIENCES, 65(1), 71–86.

By: C. Wolf*, A. Hotchkiss, J. Ostby, G. LeBlanc & L. Gray

author keywords: testosterone propionate; androgens; masculinization; prenatal exposure; sexual differentiation; anogenital distance; agenesis of the lower vagina; Sprague-Dawley rats
MeSH headings : Abnormalities, Drug-Induced / etiology; Anal Canal / abnormalities; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Genitalia, Female / abnormalities; Genitalia, Male / abnormalities; Gonadal Steroid Hormones / administration & dosage; Gonadal Steroid Hormones / physiology; Gonadal Steroid Hormones / toxicity; Male; Maternal Exposure / adverse effects; Nipples / abnormalities; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Testosterone / administration & dosage; Testosterone / physiology; Testosterone / toxicity; Toxicity Tests; Vagina / abnormalities
Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

Environmental antiecdysteroids alter embryo development in the crustacean Daphnia magna

JOURNAL OF EXPERIMENTAL ZOOLOGY, 292(3), 287–292.

By: X. Mu n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Congenital Abnormalities / physiopathology; Congenital Abnormalities / veterinary; Daphnia / embryology; Ecdysone / antagonists & inhibitors; Female; Fertility; Fungicides, Industrial / pharmacology; Molting / physiology; Pyrimidines / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2002 journal article

Juvenoid hormone methyl farnesoate is a sex determinant in the crustacean Daphnia magna

JOURNAL OF EXPERIMENTAL ZOOLOGY, 293(7), 736–739.

By: A. Olmstead n & G. Leblanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Daphnia / drug effects; Daphnia / embryology; Daphnia / growth & development; Daphnia / physiology; Environment; Fatty Acids, Unsaturated / administration & dosage; Fatty Acids, Unsaturated / pharmacology; Female; Juvenile Hormones / administration & dosage; Juvenile Hormones / pharmacology; Male; Reproduction; Sex Differentiation / drug effects; Time Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 journal article

Alterations in sexually dimorphic biotransformation of testosterone in juvenile American alligators (Alligator mississippiensis) from contaminated lakes

ENVIRONMENTAL HEALTH PERSPECTIVES, 109(12), 1257–1264.

By: M. Gunderson, G. LeBlanc* & L. Guillette

author keywords: alligator; hydroxylase; oxido-reductase; sexual dimorphism; sulfotransferase; testosterone biotransformation; UDP-glucuronosyltransferase
Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 journal article

Biotransformation and disposition of testosterone in the eastern mud snail Ilyanassa obsoleta

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 122(2), 172–180.

By: M. Gooding n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: Ilyanassa obsoleta; mud snail; fatty acid conjugates; testosterone; imposex; invertebrate endocrinology; tributyltin
MeSH headings : Acyltransferases / metabolism; Animals; Biotransformation; Chromatography, Thin Layer; Disorders of Sex Development / metabolism; Fatty Acids, Nonesterified / blood; Hydrolysis; Snails / metabolism; Testosterone / pharmacokinetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 chapter

Conjugation and Elimination of Toxicants

In E. Hodgson & R. C. Smart (Eds.), Introduction to Biochemical Toxicology (3rd ed., pp. 115–136). New York: Wiley.

By: G. LeBlanc

Ed(s): E. Hodgson & R. Smart

Source: NC State University Libraries
Added: March 26, 2021

2001 chapter

Immunochemical Techniques in Toxicology

In E. Hodgson & R. C. Smart (Eds.), Introduction to Biochemical Toxicology (3rd ed., pp. 33–50). New York: Wiley.

By: G. LeBlanc

Ed(s): E. Hodgson & R. Smart

Source: NC State University Libraries
Added: March 26, 2021

2001 journal article

Low Exposure Concentration Effects of Methoprene on Endocrine-Regulated Processes in the Crustacean Daphnia magna

Toxicological Sciences, 62(2), 268–273.

By: A. Olmstead n & G. Le Blanc

co-author countries: United States of America 🇺🇸
author keywords: methoprene; daphnid; crustacea; endocrine disruption; methyl farnesoate
MeSH headings : Animals; Daphnia / drug effects; Daphnia / growth & development; Daphnia / physiology; Dose-Response Relationship, Drug; Endocrine Glands / drug effects; Endocrine Glands / physiology; Fertility; Juvenile Hormones / toxicity; Methoprene / toxicity; Reproduction
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

2001 journal article

Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland

BIOLOGY OF REPRODUCTION, 65(5), 1496–1505.

By: O. Putz*, C. Schwartz*, S. Kim*, G. LeBlanc n, R. Cooper* & G. Prins*

co-author countries: United States of America 🇺🇸
author keywords: early development; environment; estradiol; prostate; puberty; steroid hormones; toxicology
MeSH headings : Aging; Animals; Animals, Newborn; Body Weight / drug effects; Cell Differentiation / drug effects; Dose-Response Relationship, Drug; Estradiol / administration & dosage; Estradiol / analogs & derivatives; Estradiol / pharmacology; Male; Organ Size / drug effects; Prostate / drug effects; Prostate / growth & development; Prostate / metabolism; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Sexual Maturation
Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 journal article

Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: II. Effects on male puberty and the reproductive tract

BIOLOGY OF REPRODUCTION, 65(5), 1506–1517.

By: O. Putz*, C. Schwartz*, G. LeBlanc n, R. Cooper* & G. Prins*

co-author countries: United States of America 🇺🇸
author keywords: early development; environment; estradiol; prostate; puberty; steroid hormones; toxicology
MeSH headings : Aging; Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Epididymis / drug effects; Epididymis / growth & development; Estradiol / administration & dosage; Estradiol / analogs & derivatives; Estradiol / pharmacology; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Liver / drug effects; Liver / enzymology; Male; Organ Size / drug effects; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Sexual Maturation / drug effects; Steroid Hydroxylases / metabolism; Testis / drug effects; Testis / growth & development; Testosterone / blood
Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 journal article

Temporal and quantitative changes in sexual reproductive cycling of the cladoceran Daphnia magna by a juvenile hormone analog

JOURNAL OF EXPERIMENTAL ZOOLOGY, 290(2), 148–155.

By: A. Olmstead n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Daphnia / physiology; Female; Juvenile Hormones / physiology; Male; Methoprene / pharmacology; Parthenogenesis; Reproduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 journal article

The fungicide propiconazole interferes with embryonic development of the crustacean Daphnia magna

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 20(3), 502–509.

By: K. Kast-Hutcheson, C. Rider & G. LeBlanc*

author keywords: development; embryos; crustaceans; daphnids; propiconazole
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Changes in the metabolic elimination profile of testosterone following exposure of the crustacean Daphnia magna to tributyltin

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 45(3), 296–303.

By: G. LeBlanc n & J. McLachlan n

co-author countries: United States of America 🇺🇸
MeSH headings : Androstane-3,17-diol / analogs & derivatives; Androstane-3,17-diol / analysis; Androstane-3,17-diol / metabolism; Androstenedione / analysis; Androstenedione / metabolism; Animals; Daphnia / drug effects; Daphnia / metabolism; Dihydrotestosterone / analysis; Dihydrotestosterone / metabolism; Dose-Response Relationship, Drug; Female; Glucose / metabolism; Hydroxytestosterones / analysis; Hydroxytestosterones / metabolism; Testosterone / metabolism; Trialkyltin Compounds / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Characterization of the period of sensitivity of fetal male sexual development to vinclozolin

TOXICOLOGICAL SCIENCES, 55(1), 152–161.

By: C. Wolf*, G. LeBlanc, J. Ostby & L. Gray

author keywords: vinclozolin; antiandrogen; androgen receptor; male reproductive development; critical period; levator ani; hypospadias; anogenital distance
MeSH headings : Androgen Antagonists / toxicity; Animals; Embryonic and Fetal Development / drug effects; Female; Fertility / drug effects; Fungicides, Industrial / toxicity; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / embryology; Male; Organ Size / drug effects; Oxazoles / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Long-Evans; Sexual Maturation / drug effects; Testis / abnormalities; Weight Gain / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Effects of endocrine-active chemicals on the development of sex characteristics of Daphnia magna

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 19(8), 2107–2113.

By: A. Olmstead* & G. LeBlanc*

author keywords: endocrine disruption; daphnid; sexual differentiation; invertebrate
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to the crustacean Daphnia magna

ENVIRONMENTAL HEALTH PERSPECTIVES, 108(12), 1133–1138.

By: G. LeBlanc*, X. Mu* & C. Rider

author keywords: androgens; crustacean; Daphnia magna; development; embryo; invertebrate; 4-nonylphenol; steroids; testosterone; toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Fathead minnow vitellogenin: Complementary DNA sequence and messenger RNA and protein expression after 17 beta-estradiol treatment

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 19(4), 972–981.

By: J. Korte, M. Kahl, K. Jensen, M. Pasha, L. Parks*, G. LeBlanc*, G. Ankley

author keywords: vitellogenin; Pimephales promelas; 17 beta-estradiol; mRNA; cDNA
Sources: Web Of Science, ORCID
Added: August 6, 2018

2000 journal article

Organochlorine bioaccumulation and risk for whales in a northwest Atlantic food web

Marine Environmental Research, 50(1-5), 440–441.

By: A. Weisbrod n, D. Shea n, G. Leblanc n, M. Moore* & J. Stegeman*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: November 16, 2019

2000 journal article

Petroleum pollution

Reviews in Toxicology, 3, 77–112.

By: V. Wilson & G. LeBlanc

Source: NC State University Libraries
Added: March 26, 2021

2000 chapter

Steroid hormone-regulated processes in invertebrates and their susceptibility to environmental endocrine disruption

In L. Guillette Jr. & D. A. Crain (Eds.), Environmental Endocrine Disrupters: An Evolutionary Perspective (pp. 126–154).

By: G. Le Blanc

Ed(s): L. Guillette & D. Crain

Sources: Crossref, ORCID
Added: January 28, 2020

2000 journal article

The contribution of hepatic inactivation of testosterone to the lowering of serum testosterone levels by ketoconazole

Toxicological Sciences, 54(1), 128–137.

By: V. Wilson & G. LeBlanc

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Alteration in sexually dimorphic testosterone biotransformation profiles as a biomarker of chemically induced androgen disruption in mice

ENVIRONMENTAL HEALTH PERSPECTIVES, 107(5), 377–384.

By: V. Wilson, J. McLachlan, J. Falls* & G. LeBlanc*

author keywords: androgen disruption; biomarker; biotransformation; sexually dimorphic metabolism; testosterone
Sources: Web Of Science, ORCID
Added: August 6, 2018

1999 journal article

Fathead minnow (Pimephales promelas) vitellogenin: purification, characterization and quantitative immunoassay for the detection of estrogenic compounds

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 123(2), 113–125.

By: L. Parks n, A. Cheek*, N. Denslow*, S. Heppell n, J. McLachlan*, G. LeBlanc n, C. Sullivan n

co-author countries: United States of America 🇺🇸
author keywords: enzyme-linked immunosorbant assay (ELISA); fathead minnow; vitellogenin; estrogenic compounds; 17 beta-estradiol; toxicology; reproduction; ovary
MeSH headings : Amino Acid Sequence; Animals; Blotting, Western; Chromatography, Ion Exchange; Cyprinidae; Environmental Monitoring; Enzyme-Linked Immunosorbent Assay / methods; Estrogens / analysis; Male; Molecular Sequence Data; Reproducibility of Results; Vitellogenins / biosynthesis; Vitellogenins / chemistry; Vitellogenins / isolation & purification
Sources: Web Of Science, ORCID
Added: August 6, 2018

1999 journal article

Imposex in three marine gastropod species in Chile and potential impact on muriciculture

MARINE POLLUTION BULLETIN, 38(12), 1227–1231.

By: M. Gooding n, C. Gallardo* & G. Leblanc n

co-author countries: Chile 🇨🇱 United States of America 🇺🇸
author keywords: imposex; gastropod; tributyltin; Chile; Chorus giganteus; Nucella
Sources: Web Of Science, ORCID
Added: August 6, 2018

1999 journal article

Molt-independent growth inhibition of Daphnia magna by a vertebrate antiandrogen

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 18(7), 1450–1455.

By: G. LeBlanc* & J. McLachlan

author keywords: endocrine disruption; invertebrate; daphnid; antiandrogen; growth
Sources: Web Of Science, ORCID
Added: August 6, 2018

1999 chapter

Screening approaches for the evaluation of endocrine disruption in invertebrates

In D. Henshel, M. Harrass, & M. Black (Eds.), Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for Endocrine Disruption and Environmental Assessment (Vol. 8, pp. 3–23).

By: G. LeBlanc n

co-author countries: United States of America 🇺🇸

Ed(s): D. Henshel, M. Harrass & M. Black

author keywords: endocrine disruption; invertebrates; daphnids; screening tests
Sources: Web Of Science, ORCID
Added: March 26, 2021

1999 chapter

The endocrinology of invertebrates

In M. Crane, P. L. deFur, C. Ingersoll, & L. Tattersfield (Eds.), Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment (pp. 23–106). Pensacola, FL: SETAC Press.

By: G. LeBlanc, P. Cambell, P. den Besten, R. Brown, E. Chang, J. Coats, P. deFur, T. Dhaldialla ...

Ed(s): M. Crane, P. deFur, C. Ingersoll & L. Tattersfield

Source: NC State University Libraries
Added: April 10, 2021

1999 chapter

Workshop on Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment (EDIETA): Executive Summary

In M. Crane, P. L. DeFur, C. Ingersoll, & L. Tattersfield (Eds.), Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment. Pensacola, FL: SETAC Press.

By: P. DeFur, M. Crane, L. Tattersfield, C. Ingersoll, R. Stahl, P. Matthiessen, G. LeBlanc

Ed(s): M. Crane, P. DeFur, C. Ingersoll & L. Tattersfield

Event: Workshop on Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment at Noordwijkerhout, the Netherlands on December 12-15, 1998

Source: NC State University Libraries
Added: April 8, 2021

1998 journal article

Alteration of [C-14]-testosterone metabolism after chronic exposure of Daphnia magna to tributyltin

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 34(1), 21–25.

By: E. Oberdorster*, D. Rittschof* & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Carbon Radioisotopes; Daphnia / drug effects; Daphnia / growth & development; Daphnia / metabolism; Female; Testosterone / metabolism; Trialkyltin Compounds / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 journal article

Altered metabolic elimination of testosterone and associated toxicity following exposure of Daphnia magna to nonylphenol polyethoxylate

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 39(2), 104–111.

By: W. Baldwin n, S. Graham n, D. Shea n & G. LeBlanc n

co-author countries: United States of America 🇺🇸

Contributors: W. Baldwin n, S. Graham n, D. Shea n & G. LeBlanc n

MeSH headings : Animals; Culture Media; Daphnia / drug effects; Daphnia / physiology; Detergents / toxicity; Ethylene Glycols / toxicity; Female; Glucose / metabolism; Phenols / metabolism; Sulfates / metabolism; Testosterone / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 chapter

Bioaccumulation

In P. Wexler (Ed.), Encyclopedia of Toxicology (Vol. 1, p. 148). New York: Academic Press Inc.

By: J. Hamelink & G. Le Blanc

Ed(s): P. Wexler

Source: NC State University Libraries
Added: April 10, 2021

1998 journal article

Endosulfan elevates testosterone biotransformation and clearance in CD-1 mice

TOXICOLOGY AND APPLIED PHARMACOLOGY, 148(1), 158–168.

By: V. Wilson n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Biotransformation; Body Weight / drug effects; Cytosol / drug effects; Cytosol / metabolism; Dose-Response Relationship, Drug; Endosulfan / toxicity; Estradiol / blood; Female; Hydrocarbons, Chlorinated; Insecticides / toxicity; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Male; Mice; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Organ Size / drug effects; Testosterone / pharmacokinetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 journal article

Heat resistance of Alicyclobacillus acidoterrestris spores as affected by various pH values and organic acids

JOURNAL OF FOOD PROTECTION, 61(1), 41–46.

By: A. Pontius n, J. Rushing n & P. Foegeding n

co-author countries: United States of America 🇺🇸
MeSH headings : Bacillaceae / isolation & purification; Bacillaceae / physiology; Beverages / microbiology; Carboxylic Acids / pharmacology; Food Contamination / prevention & control; Food Microbiology; Fruit / microbiology; Hot Temperature; Hydrogen-Ion Concentration; Spores, Bacterial / growth & development
Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 journal article

Involvement of multiple biotransformation processes in the metabolic elimination of testosterone by juvenile and adult fathead minnows (Pimephales promelas)

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 112(1), 69–79.

By: L. Parks n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Aging; Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cyprinidae / metabolism; Female; Gas Chromatography-Mass Spectrometry; Hydroxylation; Male; Metabolic Clearance Rate; Oxidation-Reduction; Sex Characteristics; Testosterone / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 review

Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife

[Review of ]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 17(1), 68–87.

By: G. Ankley*, E. Mihaich, R. Stahl, D. Tillitt, T. Colborn, S. McMaster, R. Miller, J. Bantle ...

co-author countries: United States of America 🇺🇸
author keywords: estrogen; androgen; endocrine disruption; wildlife; screening
Sources: Web Of Science, ORCID
Added: August 6, 2018

1998 journal article

The state of the debate

Forum for Applied Research and Public Policy, 13(3), 6–10.

By: G. Le Blanc

Source: NC State University Libraries
Added: April 8, 2021

1998 journal article

Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype

JOURNAL OF NATURAL PRODUCTS, 61(1), 112–115.

By: G. Ma*, T. Wang, L. Yin, Y. Pan, Y. Guo*, G. LeBlanc n, M. Reinecke, W. Watson, M. Krawiec

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; Animals; Antineoplastic Agents, Phytogenic / isolation & purification; Antineoplastic Agents, Phytogenic / pharmacology; Doxorubicin / pharmacology; Genes, MDR / drug effects; Humans; Magnetic Resonance Spectroscopy; Mice; Phenanthrenes / isolation & purification; Phenanthrenes / pharmacology; Phenotype; Plant Stems / chemistry; Structure-Activity Relationship; Tumor Cells, Cultured; X-Ray Diffraction
Sources: Web Of Science, ORCID
Added: August 6, 2018

1997 journal article

At the cutting edge - Pesticides: Multiple mechanisms of demasculinization

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 126(1), 1–5.

By: G. LeBlanc n, L. Bain n & V. Wilson n

co-author countries: United States of America 🇺🇸
author keywords: pesticides; demasculinization; feminization; endocrine; steroid hormones; receptors; biotransformation; synergism
MeSH headings : Androgen Antagonists / pharmacology; Androgen Receptor Antagonists; Animals; Female; Feminization / chemically induced; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Humans; Male; Pesticides / pharmacology; Receptors, Estrogen / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

1997 chapter

Basics of Environmental Toxicology

In E. Hodgson & P. E. Levi (Eds.), A Textbook of Modern Toxicology (2nd ed., pp. 389–406). Stamford, CT: Appleton & Lange.

By: G. Le Blanc

Ed(s): E. Hodgson & P. Levi

Source: NC State University Libraries
Added: October 24, 2021

1997 chapter

Chemical contamination affects wildlife

In C. P. Cozic (Ed.), Garbage & Waste (pp. 92–95). San Diego, California: Greenhaven Press, Inc.

By: G. Le Blanc

Ed(s): C. Cozic

Source: NC State University Libraries
Added: October 24, 2021

1997 journal article

Chronic toxicity of environmental contaminants: Sentinels and biomarkers

Environmental Health Perspectives, 105(Suppl. 1), 65–80.

By: G. LeBlanc* & L. Bain*

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

1997 chapter

Elimination of Toxicants

In E. Hodgson & P. E. Levi (Eds.), A Textbook of Modern Toxicology (2nd ed., pp. 107–118). Stamford, CT: Appleton & Lange.

By: P. Levi, E. Hodgson & G. Le Blanc

Ed(s): E. Hodgson & P. Levi

Source: NC State University Libraries
Added: October 24, 2021

1997 chapter

Invertebrates as sentinels of xenobiotic-induced endocrine disruption

In P. Guttry (Ed.), Endocrine Disruptors: Advances in Measuring and Analyzing Their Effects (pp. 1–24). Southborough, MA: International Business Communications.

By: G. Le Blanc

Ed(s): P. Guttry

Source: NC State University Libraries
Added: October 24, 2021

1997 journal article

Metabolic androgenization of female Daphnia magna by the xenoestrogen 4-nonylphenol

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 16(9), 1905–1911.

By: W. Baldwin*, S. Graham*, D. Shea* & G. LeBlanc*

Contributors: W. Baldwin*, S. Graham*, D. Shea* & G. Leblanc*

author keywords: 4-nonylphenol; androgenization; steroid metabolism; Daphnia magna
Sources: Web Of Science, ORCID
Added: August 6, 2018

1997 journal article

Reversal of multidrug resistance by derivatives of acrivastine: a study of structure activity relationships of P glycoprotein inhibitors in vitro and in vivo

Oncology Reports, 4(6), 1353–1360.

By: J. Christensen, L. Parks, R. McNutt & G. Leblanc

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein

ENVIRONMENTAL HEALTH PERSPECTIVES, 105(8), 812–818.

By: L. Bain*, J. McLachlan & G. LeBlanc*

author keywords: multidrug resistance; multixenobiotic resistance; pesticides; P-glycoprotein; structure-activity relationships
Sources: Web Of Science, ORCID
Added: August 6, 2018

1996 journal article

Expression and induction of an immunochemically related class of glutathione S-transferases in Daphnia magna

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 113(2), 261–267.

By: W. Baldwin n & G. Leblanc n

co-author countries: United States of America 🇺🇸
author keywords: antibodies; 1-chloro-2,4-dinitrobenzene; Daphnia magna; glutathione S-transferases; phenobarbital
MeSH headings : Animals; Chromatography, Affinity; Cytosol / enzymology; Daphnia / enzymology; Enzyme Induction / drug effects; Glutathione Transferase / biosynthesis; Glutathione Transferase / immunology; Glutathione Transferase / isolation & purification; Immunoblotting; Isoelectric Focusing; Isoenzymes / biosynthesis; Isoenzymes / immunology; Isoenzymes / isolation & purification; Kinetics; Phenobarbital / pharmacology
Sources: Crossref, ORCID
Added: January 5, 2020

1996 journal article

Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein

Toxicology and Applied Pharmacology, 141(1), 288–298.

By: L. Bain n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: January 5, 2020

1996 journal article

Mobilization of Pentachlorophenol by GlutathioneS-Transferase μ Increases Cellular Toxicity

Pesticide Biochemistry and Physiology, 54(1), 65–72.

By: L. Bain n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

1996 journal article

Overexpression of ap-glycoprotein in hepatocellular carcinomas from woodchuck hepatitis virus-infected woodchucks (Marmota monax)

Hepatology, 23(4), 662–668.

By: S. Dunn n, C. Hughes n, G. LeBlanc n & J. Cullen n

co-author countries: United States of America 🇺🇸
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / analysis; ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Animals; Base Sequence; Carcinoma, Hepatocellular / drug therapy; Carcinoma, Hepatocellular / etiology; Carcinoma, Hepatocellular / metabolism; Hepatitis B / complications; Hepatitis B Virus, Woodchuck; Liver Neoplasms / drug therapy; Liver Neoplasms / etiology; Liver Neoplasms / metabolism; Marmota; Molecular Sequence Data; RNA, Messenger / analysis
Sources: Crossref, ORCID
Added: January 5, 2020

1996 journal article

Reductions in steroid hormone biotransformation/elimination as a biomarker of pentachlorophenol chronic toxicity

Aquatic Toxicology, 34(4), 291–303.

By: L. Parks n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: pentachlorophenol; chronic toxicity; endocrine disrupter; biomarker; Daphnia; steroid hormones; biotransformation; hydroxylase; glucosyl transferase; sulfotransferase
Sources: Crossref, ORCID
Added: January 5, 2020

1996 journal article

Reversal of multi-drug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol

Cancer Research, 56(3), 574–581.

By: J. Christensen & G. Le Blanc

Source: NC State University Libraries
Added: April 8, 2021

1995 journal article

Are environmental sentinels signaling?

Environmental Health Perspectives, 103(10), 888–890.

By: G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Endocrine Glands / drug effects; Environmental Pollutants / toxicity; Humans; Pesticides / toxicity; Reproduction / drug effects
Sources: Crossref, ORCID
Added: January 28, 2020

1995 journal article

PHYSIOLOGICAL AND BIOCHEMICAL PERTURBATIONS IN DAPHNIA MAGNA FOLLOWING EXPOSURE TO THE MODEL ENVIRONMENTAL ESTROGEN DIETHYLSTILBESTROL

Environmental Toxicology and Chemistry, 14(6), 945.

By: W. Baldwin, D. Milam & G. LeBlanc*

author keywords: DAPHNIA; ESTROGENS; DIETHYLSTILBESTROL; BIOMARKER; BIOTRANSFORMATION
Sources: Crossref, ORCID
Added: January 28, 2020

1995 journal article

Subtle effects: devastating consequences

SETAC News, 15(3), 30–31.

By: G. Le Blanc

Source: NC State University Libraries
Added: October 24, 2021

1995 journal article

Trophic-Level Differences in the Bioconcentration of Chemicals: Implications in Assessing Environmental Biomagnification

Environmental Science & Technology, 29(1), 154–160.

By: G. LeBlanc*

Sources: Crossref, ORCID
Added: January 5, 2020

1994 journal article

Assessing deleterious ecosystem-level effects of environmental pollutants as a means of avoiding evolutionary consequences.

Environmental Health Perspectives, 102(3), 266–267.

By: G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: ECOTOXICOLOGY; EVOLUTION; MESOCOSMS; MICROCOSMS; MODEL ECOSYSTEMS; POLLUTION
MeSH headings : Animals; Biological Evolution; Ecosystem; Environmental Pollutants / pharmacology; Humans
Sources: Crossref, ORCID
Added: January 28, 2020

1994 journal article

Effect of the plant compound indole-3-carbinol on hepatic cholesterol homoeostasis

Food and Chemical Toxicology, 32(7), 633–639.

By: G. Le Blanc n, J. Stuart n, S. Dunn n & W. Baldwin n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cholesterol / blood; Cholesterol / chemistry; Cholesterol 7-alpha-Hydroxylase / metabolism; Homeostasis / drug effects; Indoles / pharmacology; Liver / chemistry; Liver / drug effects; Male; Mice; Microsomes, Liver / chemistry; Microsomes, Liver / drug effects; Sterol Esterase / metabolism; Sterol O-Acyltransferase / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

1994 journal article

Hepatic vectorial transport of xenobiotics

Chemico-Biological Interactions, 90(2), 101–120.

By: G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: TRANSPORT; TRANSFER; XENOBIOTICS; INFLUX; EFFLUX; LIVER
MeSH headings : 3-Hydroxysteroid Dehydrogenases / metabolism; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); ATP Binding Cassette Transporter, Subfamily B, Member 1; Animals; Biological Transport, Active; Carrier Proteins / metabolism; Cell Membrane / metabolism; Cell Nucleus / metabolism; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Glutathione Transferase / metabolism; Humans; Liver / drug effects; Liver / metabolism; Membrane Glycoproteins / metabolism; Neoplasm Proteins; Tumor Suppressor Proteins; Xenobiotics / pharmacokinetics; Xenobiotics / toxicity
Sources: Crossref, ORCID
Added: January 28, 2020

1994 journal article

Hypocholesterolemic properties of plant indoles

Biochemical Pharmacology, 47(2), 359–364.

By: S. Dunn n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: INDOLE-3-CARBINOL; CHOLESTEROL; ACYL-COA-CHOLESTEROL ACYLTRANSFERASE
MeSH headings : Animals; Anticholesteremic Agents / pharmacology; Cholesterol, LDL / blood; Cholesterol, VLDL / blood; Down-Regulation; Glucosinolates / pharmacology; Indoles / chemical synthesis; Indoles / isolation & purification; Indoles / pharmacology; Mice; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Plants / chemistry; Sterol O-Acyltransferase / antagonists & inhibitors; Sterol O-Acyltransferase / metabolism
Sources: Crossref, ORCID
Added: January 28, 2020

1994 journal article

IDENTIFICATION OF MULTIPLE STEROID HYDROXYLASES IN DAPHNIA MAGNA AND THEIR MODULATION BY XENOBIOTICS

Environmental Toxicology and Chemistry, 13(7), 1013.

By: W. Baldwin & G. LeBlanc*

author keywords: DAPHNIA; BIOMARKER; P450; TESTOSTERONE; METABOLISM
Sources: Crossref, ORCID
Added: February 10, 2020

1994 journal article

In vivo biotransformation of testosterone by phase I and II detoxication enzymes and their modulation by 20-hydroxyecdysone in Daphnia magna

Aquatic Toxicology, 29(1-2), 103–117.

By: W. Baldwin n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
author keywords: TESTOSTERONE; DAPHNIA-MAGNA; OXIDATION; CONJUGATION; 20-HYDROXYECDYSONE
Sources: Crossref, ORCID
Added: February 10, 2020

1993 journal article

Elevation of serum cholesterol levels in mice by the antioxidant butylated hydroxyanisole

Biochemical Pharmacology, 45(2), 513–515.

By: G. Le Blanc n & J. Gillette n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Antioxidants / pharmacology; Body Weight; Butylated Hydroxyanisole / pharmacology; Cholesterol / blood; Cholesterol, Dietary / administration & dosage; Male; Mice; Microsomes, Liver / metabolism; Probucol / pharmacology; Up-Regulation
Sources: Web Of Science, ORCID
Added: October 28, 2021

1992 journal article

Hormonal perturbations in patients with testicular cancer treated with cisplatin

Cancer, 69(9), 2306–2310.

By: G. Leblanc n, P. Kantoff*, S. Ng*, E. Frei* & D. Waxman*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 10, 2020

1992 journal article

Photoaffinity labelling of steroid-hormone-binding glutathione S-transferases with [3H]methyltrienolone. Inhibition of steroid-binding activity by the anticarcinogen indole-3-carbinol

Biochemical Journal, 288(2), 361–367.

By: D. Danger n, W. Baldwin n & G. LeBlanc n

co-author countries: United States of America 🇺🇸
MeSH headings : Affinity Labels; Animals; Butylated Hydroxyanisole / pharmacology; Cytosol / enzymology; Enzyme Induction; Glutathione Transferase / chemistry; Indoles / chemistry; Liver / enzymology; Male; Metribolone / chemistry; Mice; Phenobarbital / pharmacology; Photochemistry; Precipitin Tests; Protein Binding; Steroids / metabolism
Sources: Web Of Science, ORCID
Added: October 28, 2021

1992 journal article

Platinum Anticancer Drugs Modulate P-450 mRNA Levels and Differentially Alter Hepatic Drug and Steroid Hormone Metabolism in Male and Female Rats

Cancer Research, 52(3), 540–547.

By: G. Le Blanc, S. Sundseth, G. Weber & D. Waxman

Source: NC State University Libraries
Added: October 28, 2021

1992 journal article

The anti-carcinogenic plant compound indole-3-carbinol differentially modulates P450-mediated steroid hydroxylase activities in mice

Chemico-Biological Interactions, 83(2), 155–169.

By: W. Baldwin n & G. Leblanc n

co-author countries: United States of America 🇺🇸
author keywords: INDOLE-3-CARBINOL; P450; ANTICARCINOGENESIS; STEROID HYDROXYLASE
MeSH headings : Animals; Anticarcinogenic Agents / pharmacology; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System / metabolism; Enzyme Induction / drug effects; Indoles / pharmacology; Liver / enzymology; Male; Mice; Mice, Inbred Strains; Oxidoreductases / metabolism; Steroid Hydroxylases / metabolism
Sources: Crossref, ORCID
Added: February 10, 2020

1990 journal article

Hormonal Regulation of Levels of the Messenger RNA Encoding Hepatic P450 2c (IIC11), a Constitutive Male-Specific Form of Cytochrome P450

Molecular Endocrinology, 4(2), 295–303.

By: R. Janeczko*, D. Waxman, G. Le Blanc, A. Morville & M. Adesnik

co-author countries: United States of America 🇺🇸
MeSH headings : Aging / genetics; Alpha-Globulins / genetics; Alpha-Globulins / metabolism; Androgens / pharmacology; Androgens / physiology; Animals; Base Sequence; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DNA / analysis; DNA / genetics; Estrogens / pharmacology; Estrogens / physiology; Gene Expression Regulation, Enzymologic; Genetic Vectors; Growth Hormone / pharmacology; Growth Hormone / physiology; Immunoblotting; Liver / enzymology; Male; Orchiectomy; Pituitary Gland / physiology; RNA, Messenger / drug effects; RNA, Messenger / genetics; Rats; Rats, Inbred Strains; Sex Characteristics; Steroid 16-alpha-Hydroxylase; Transcription, Genetic / drug effects
Sources: Web Of Science, ORCID
Added: November 16, 2021

1990 journal article

Mechanisms of cyclophosphamide action on hepatic P-450 expression

Cancer Research, 50(18), 5720–5726.

By: G. Le Blanc & D. Waxman

Source: NC State University Libraries
Added: November 16, 2021

1990 journal article

Pituitary Regulation of the Male-Specific Steroid 6β-Hydroxylase P-450 2a (gene product IIIA2) in Adult Rat Liver. Suppressive Influence of Growth Hormone and Thyroxine Acting at a Pretranslational Level

Molecular Endocrinology, 4(3), 447–454.

By: D. Waxman*, P. Ram*, G. Notani Gur*, G. Le Blanc*, J. Alberta*, J. Morrissey*, S. Sundseth*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Female; Gene Expression Regulation, Enzymologic / drug effects; Gene Expression Regulation, Enzymologic / physiology; Growth Hormone / physiology; Hypophysectomy; Liver / enzymology; Male; Pituitary Gland / physiology; Protein Biosynthesis / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Rats, Inbred Strains; Steroid Hydroxylases / genetics; Steroid Hydroxylases / metabolism; Thyroxine / physiology
Sources: Web Of Science, ORCID
Added: November 16, 2021

1990 journal article

Regulation and ligand-binding specificities of two sex-specific bile acid-binding proteins of rat liver cytosol.

Journal of Biological Chemistry, 265(10), 5654–5661.

By: G. LeBlanc* & D. Waxman*

co-author countries: United States of America 🇺🇸
Sources: NC State University Libraries, ORCID
Added: October 28, 2021

1989 journal article

Female-Predominant Rat Hepatic P-450 Forms j (IIE1) and 3 (IIA1) Are under Hormonal Regulatory Controls Distinct from Those of the Sex-Specific P-450 Forms

Endocrinology, 124(6), 2954–2966.

By: D. Waxman*, J. Morrissey* & G. Leblanc*

co-author countries: United States of America 🇺🇸
MeSH headings : Aging; Animals; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Estrenes / pharmacology; Female; Growth Hormone / pharmacology; Hypophysectomy; Isoenzymes / genetics; Isoenzymes / metabolism; Liver / growth & development; Male; Metribolone; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Orchiectomy; Ovariectomy; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reference Values; Sex Factors
Sources: Crossref, ORCID
Added: February 10, 2020

1989 journal article

Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver. Pituitary control of hepatic NADPH cytochrome P-450 reductase

Molecular Pharmacology, 35(4), 519–525.

By: D. Waxman, J. Morrissey & G. Le Blanc

Source: NC State University Libraries
Added: November 16, 2021

1989 journal article

Interaction of Anticancer Drugs with Hepatic Monooxygenase Enzymes

Drug Metabolism Reviews, 20(2-4), 395–439.

By: G. LeBlanc* & D. Waxman*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biotransformation; Cytochrome P-450 Enzyme System / metabolism; Humans; Liver / drug effects; Liver / enzymology; Mixed Function Oxygenases / metabolism
Sources: Crossref, ORCID
Added: February 10, 2020

1989 journal article

Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone

Archives of Biochemistry and Biophysics, 271(2), 508–514.

By: H. Yeowell*, D. Waxman*, G. LeBlanc*, P. Linko* & J. Goldstein*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases; Chorionic Gonadotropin / pharmacology; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Estrenes / pharmacology; Gonadotropin-Releasing Hormone / pharmacology; Hypothalamus / drug effects; Hypothalamus / physiology; Liver / enzymology; Male; Metribolone; Microsomes, Liver / enzymology; Orchiectomy; Pituitary Gland / drug effects; Pituitary Gland / physiology; Polychlorinated Biphenyls / pharmacology; RNA, Messenger / metabolism; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases / metabolism; Testis / drug effects; Testis / physiology; Testosterone / blood
Sources: Crossref, ORCID
Added: February 10, 2020

1988 journal article

Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression

The Journal of Biological Chemistry, 263(23), 11396–11406.

By: D. Waxman*, G. Le Blanc*, J. Morrissey*, J. Staunton* & D. Lapenson*

co-author countries: United States of America 🇺🇸
Sources: NC State University Libraries, ORCID
Added: November 24, 2021

1988 journal article

Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes

The Journal of Biological Chemistry, 263(30), 15732–15739.

By: G. Le Blanc* & D. Waxman*

co-author countries: United States of America 🇺🇸
Sources: NC State University Libraries, ORCID
Added: November 24, 2021

1988 journal article

Induction of cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl

Molecular Pharmacology, 33(3), 272–278.

By: H. Yeowell, D. Waxman, G. Le Blanc, P. Linko & J. Goldstein

Source: NC State University Libraries
Added: November 16, 2021

1988 journal article

Relationships between the structures of chlorinated phenols, their toxicity, and their ability to induce glutathione S-transferase activity in Daphnia magna

Aquatic Toxicology, 12(2), 147–155.

By: G. LeBlanc*, B. Hilgenberg* & B. Cochrane*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 10, 2020

1987 journal article

A rapid method for staining proteins in acrylamide gels

Analytical Biochemistry, 161(1), 172–175.

By: G. LeBlanc* & B. Cochrane*

co-author countries: United States of America 🇺🇸
MeSH headings : Electrophoresis, Polyacrylamide Gel / methods; Glutathione; Nitroblue Tetrazolium; Oxidation-Reduction; Proteins / isolation & purification; Rosaniline Dyes; Staining and Labeling / methods
Sources: Crossref, ORCID
Added: February 10, 2020

1987 journal article

Identification of multiple glutathione S-tansferases from Daphnia magna

Comparative Biochemistry and Physiology. B, Comparative Biochemistry, 88(1), 39–45.

By: G. Le Blanc* & B. Cochrane*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Chromatography, Affinity; Chromatography, Ion Exchange; Daphnia / enzymology; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase / isolation & purification; Glutathione Transferase / metabolism; Isoenzymes / isolation & purification; Isoenzymes / metabolism; Kinetics; Molecular Weight
Sources: Web Of Science, ORCID
Added: November 24, 2021

1987 journal article

The genetics of xenobiotic metabolism in Drosophila—IV: Purification and characterization of the major glutathione S-transferase

Insect Biochemistry, 17(5), 731–738.

By: B. Cochrane*, J. Morrissey* & G. LeBlanc*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 24, 2020

1986 journal article

The genetics of xenobiotic metabolism in Drosophila. I. Genetics and environmental factors affecting glutathione S-transferase in larvae

Biochemical Pharmacology, 35(10), 1679–1684.

By: B. Cochrane* & G. LeBlanc*

co-author countries: United States of America 🇺🇸
MeSH headings : Benzene Derivatives / pharmacology; Chromosome Mapping; Dinitrochlorobenzene / metabolism; Drosophila melanogaster / enzymology; Drosophila melanogaster / genetics; Ethacrynic Acid / metabolism; Glutathione Transferase / analysis; Glutathione Transferase / genetics; Hydrogen-Ion Concentration; Isoenzymes / analysis; Larva / enzymology; Substrate Specificity
Sources: Crossref, ORCID
Added: February 24, 2020

1985 chapter

A Method of Assessing the Toxicity of Contaminated Freshwater Sediments

In R. D. Cardwell, R. Purdy, & R. B. Comotto (Eds.), Aquatic Toxicology and Hazard Assessment: Seventh Symposium (pp. 269–283).

By: G. LeBlanc* & D. Surprenant*

co-author countries: Australia 🇦🇺 United States of America 🇺🇸

Ed(s): R. Cardwell, R. Purdy & R. Comotto

Sources: Crossref, ORCID
Added: October 29, 2020

1985 journal article

Effects of copper on the competitive interactions of two species of cladocera

Environmental Pollution Series A, Ecological and Biological, 37(1), 13–25.

By: G. LeBlanc*

Sources: Crossref, ORCID
Added: February 10, 2020

1985 journal article

Modulation of substrate-specific glutathione S-transferase activity in daphnia magna with concomitant effects on toxicity tolerance

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 82(1), 37–42.

By: G. Leblanc* & B. Cochrane*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Daphnia / drug effects; Daphnia / enzymology; Dinitrochlorobenzene / pharmacology; Enzyme Induction / drug effects; Epoxy Compounds / pharmacology; Ethacrynic Acid / pharmacology; Glutathione Transferase / metabolism; Nitrobenzenes / pharmacology; Nitrophenols / pharmacology; Pentachlorophenol / pharmacology; Substrate Specificity
Sources: Crossref, ORCID
Added: February 10, 2020

1984 journal article

Antimony and thallium toxicity to embryos and larvae of fathead minnows (Pimephales promelas)

Bulletin of Environmental Contamination and Toxicology, 32(1), 565–569.

By: G. LeBlanc* & J. Dean*

co-author countries: Australia 🇦🇺
MeSH headings : Animals; Antimony / toxicity; Carps / physiology; Cyprinidae / physiology; Embryo, Nonmammalian / drug effects; Larva / drug effects; Thallium / toxicity
Sources: Crossref, ORCID
Added: February 10, 2020

1984 chapter

Comparative structure-toxicity relationships between acute and chronic effects to aquatic organisms

In K. L. E. Kaiser (Ed.), QSAR in Environmental Toxicology (pp. 245–260). Dordrecht, Holland: Reidel Publishing Company.

By: G. Le Blanc

Ed(s): K. Kaiser

Source: NC State University Libraries
Added: November 24, 2021

1984 journal article

Interspecies relationships in acute toxicity of chemicals to aquatic organisms

Environmental Toxicology and Chemistry, 3(1), 47–60.

By: G. Leblanc*

Sources: Crossref, ORCID
Added: February 10, 2020

1984 journal article

The influence of mineral salts on the fecundity of the water flea (Daphnia magna) and the implications on toxicity testing of industrial wastewater

Hydrobiologia, 108, 25–31.

By: G. Le Blanc & D. Surprenant

Sources: Web Of Science, ORCID
Added: November 24, 2021

1984 journal article

The influence of speciation on the toxicity of silver to fathead minnow (Pimephales promelas)

Environmental Toxicology and Chemistry, 3(1), 37–46.

By: G. Leblanc*, J. Mastone, A. Paradice, B. Wilson, H. Jr & K. Robillard*

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: February 10, 2020

1983 journal article

The acute and chronic toxicity of acetone, dimethyl formamide, and triethylene glycol to Daphnia magna (Straus)

Archives of Environmental Contamination and Toxicology, 12(3), 305–310.

By: G. LeBlanc* & D. Surprenant

Sources: Crossref, ORCID
Added: February 10, 2020

1983 chapter

The effects of food concentration, animal interactions and water volume on survival, growth, and reproduction of Daphnia magna under flow-through conditions

In W. E. Bishop, R. D. Cardwell, & B. B. Heidolph (Eds.), Aquatic Toxicology and Hazard Assessment (pp. 494–508). Philadelphia: American Society for Testing and Materials.

By: G. Le Blanc, D. Schoenfeld & D. Surprenant

Ed(s): W. Bishop, R. Cardwell & B. Heidolph

Source: NC State University Libraries
Added: November 24, 2021

1982 journal article

Laboratory investigation into the development of resistance of Daphnia magna (strauus) to environmental pollutants

Environmental Pollution Series A, Ecological and Biological, 27(4), 309–322.

By: G. LeBlanc*

Sources: Crossref, ORCID
Added: February 10, 2020

1981 journal article

Acute toxicity of priority pollutants to bluegill (Lepomis macrochirus)

Bulletin of Environmental Contamination and Toxicology, 26(1), 446–452.

By: R. Buccafusco*, S. Ells* & G. LeBlanc*

co-author countries: Australia 🇦🇺 United States of America 🇺🇸
MeSH headings : Animals; Fishes / physiology; Fresh Water / analysis; Hydrogen-Ion Concentration; Lethal Dose 50; Oxygen / analysis; Solubility; Water Pollutants / toxicity; Water Pollutants, Chemical / toxicity
Sources: Crossref, ORCID
Added: February 10, 2020

1980 journal article

Acute toxicity of priority pollutants to water flea (Daphnia magna)

Bulletin of Environmental Contamination and Toxicology, 24(1), 684–691.

By: G. LeBlanc*

co-author countries: Australia 🇦🇺
MeSH headings : Daphnia / drug effects; Humans; Lethal Dose 50; Water Pollutants / toxicity; Water Pollutants, Chemical / toxicity
Sources: Crossref, ORCID
Added: February 10, 2020

1980 journal article

An environmental safety assessment of butyl benzyl phthalate

Environmental Science & Technology, 14(3), 301–305.

By: W. Gledhill, R. Kaley, W. Adams, O. Hicks, P. Michael, V. Saeger, G. LeBlanc*

Sources: Crossref, ORCID
Added: February 10, 2020

1979 journal article

Utilization of bacterial colony counters to count early instar water fleas (Daphnia magna)

Bulletin of Environmental Contamination and Toxicology, 23(1), 837–839.

By: G. LeBlanc*

co-author countries: Australia 🇦🇺
MeSH headings : Animals; Bacteriological Techniques / instrumentation; Daphnia / physiology
Sources: Crossref, ORCID
Added: February 10, 2020

1978 report

The chronic toxicity of methomyl, propachlor, baygon, and baytex to aquatic organisms

[68-03-0310]. Duluth, Minnesota: U.S. Environmental Protection Agency.

By: S. Sauter, G. Le Blanc, S. Ells & K. Buxton

Source: NC State University Libraries
Added: November 24, 2021

1977 report

Acute toxicity of HMX to aquatic organisms

(Contract No. DAMD-17-74-C-4101). Fort Detrick, Maryland: U.S. Army Medical Research and Development Command.

By: R. Bentley, J. Dean, S. Ells, T. Hollister, G. Le Blanc, S. Sauter, B. Sleight

Source: NC State University Libraries
Added: November 24, 2021

1977 report

Laboratory Evaluation of the Toxicity of Cyclotrimethylene Trinitramine (RDX) to Aquatic Organisms

(Contract No. DAMD-17-74-C-4101).

By: R. Bentley, J. Dean, S. Ells, T. Hollister, G. Le Blanc, S. Sauter, B. Sleight III

Sources: Crossref, ORCID
Added: October 29, 2020

1976 report

Acute toxicity of diisopropylmethyl phosphate and dichloropentadiene to aquatic organisms

(Contract No. DAMD-17-75-C-5073). Fort Detrick, Maryland: U.S. Army Medical Research and Development Command.

By: R. Bentley, G. Le Blanc, T. Hollister & B. Sleight

Source: NC State University Libraries
Added: November 24, 2021

1976 report

Laboratory evaluation of the toxicity of nitrocellulose to aquatic organisms

(Contract No. DAMD-17-74-C-401). Fort Derrick, Maryland: U.S. Army Medical Research and Development Command.

By: R. Bentley, G. Le Blanc, T. Hollister & B. Sleight

Source: NC State University Libraries
Added: November 24, 2021

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