Gerald A LeBlanc

Ignored microplastic sources from plastic bottle recycling

SCIENCE OF THE TOTAL ENVIRONMENT, 838.

Organotins in a food web from the Three Gorges Reservoir, China: Trophic enrichment and potential health risk

SCIENCE OF THE TOTAL ENVIRONMENT, 845.

A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology

[Review of ]. FRONTIERS IN ENDOCRINOLOGY, 12.

A proposed nomenclature for microplastic contaminants

MARINE POLLUTION BULLETIN, 172.

An effective method for evaluation of microplastic contaminant in gastropod from Taihu Lake, China

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 27(18), 22878–22887.

Endocrine Disruption in Invertebrates: A Survey of Research Progress

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(21), 13365–13369.

Investigation of the microplastics profile in sludge from China's largest Water reclamation plant using a feasible isolation device

JOURNAL OF HAZARDOUS MATERIALS, 388.

Involvement of glutamate and serotonin transmitter systems in male sex determination in Daphnia pulex

JOURNAL OF INSECT PHYSIOLOGY, 121.

Phthalate Esters and Their Potential Risk in PET Bottled Water Stored under Common Conditions

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 17(1).

Being certain about uncertainty

Le Blanc, G. A. (2019, July 2). https://news.ncsu.edu/2019/07/being-certain-about-uncertainty/

Complementary roles of photoperiod and temperature in environmental sex determination in Daphnia spp.

The Journal of Experimental Biology, 222(4), jeb195289.

Freshwater snail Parafossarulus striatulus estrogen receptor: Characteristics and expression profiles under lab and field exposure

CHEMOSPHERE, 220, 611–619.

The role of nuclear receptor E75 in regulating the molt cycle of Daphnia magna and consequences of its disruption

PLOS ONE, 14(8), e0221642.

Hemoglobin Levels Modulate Nitrite Toxicity to Daphnia magna

Scientific Reports, 8(1).

New method lights the way for future toxicity testing

Le Blanc, G. A. (2018, January). Euro Cosmetics, (26).

No impacts of microcystins on wild freshwater snail Bellamya Aeruginosa fecundity from a eutrophic lake

Environmental Toxicology and Pharmacology, 60, 165–168.

Agonist-mediated assembly of the crustacean methyl farnesoate receptor

Scientific Reports, 7(1).

Ligand-Mediated Receptor Assembly as an End Point for High-Throughput Chemical Toxicity Screening

Environmental Science & Technology, 51(16), 9327–9333.

Preliminary evidence for snail deformation from a Eutrophic lake

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 53, 219–226.

The value of science is reflected in your everyday decisions

Le Blanc, G. A. (2017, March 31). https://news.ncsu.edu/2017/03/the-value-of-science-leblanc-2017/

Validation of a two-generational reproduction test in Daphnia magna: An interlaboratory exercise

Science of The Total Environment, 579, 1073–1083.

Validation of a two-generational reproduction test in Daphnia magna: an interlaboratory exercise

Science of the Total Environment, 579, 1073–1083.

Differential Interactions of the Flame Retardant Triphenyl Phosphate within the PPAR Signaling Network

MOJ Toxicology, 2(3).

Retrospective: Acute Toxicity of Priority Pollutants

Bulletin of Environmental Contamination and Toxicology, 97(3), 301–302.

Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing

Estimation of time-varying mortality rates using continuous models for Daphnia magna

APPLIED MATHEMATICS LETTERS, 44, 12–16.

Males on demand: the environmental-neuro-endocrine control of male sex determination in daphnids

[Review of ]. FEBS JOURNAL, 282(21), 4080–4093.

Short-term fish reproduction assays with methyl tertiary butyl ether with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity

Environmental Toxicology and Chemistry, 34(9), 2013–2022.

Statistical validation of structured population models for Daphnia magna

Mathematical Biosciences, 266, 73–84.

Endocrine regulation of predator-induced phenotypic plasticity

Oecologia, 176(3), 625–635.

Estrogen alters the profile of the transcriptome in river snail Bellamya aeruginosa

Ecotoxicology, 24(2), 330–338.

A Transgenerational Endocrine Signaling Pathway in Crustacea

PLoS ONE, 8(4), e61715.

Detailed review paper on the state of the science on novel in vitro and in vivo screening and testing methods and endpoints for evaluating endocrine disruptors

(Series on Testing & Assessment No. 178). Organization for Economic Co-operation and Development.

Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna)

AQUATIC TOXICOLOGY, 101(2), 351–357.

Tributyltin Synergizes with 20-Hydroxyecdysone to Produce Endocrine Toxicity

TOXICOLOGICAL SCIENCES, 123(1), 71–79.

Acute Toxicity

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 225–236). Hoboken, NJ: Wiley.

Elimination of Toxicants

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 213–222). Hoboken, NJ: Wiley.

Endocrine Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 345–362). Hoboken, NJ: Wiley.

Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs

[Review of ]. ECOTOXICOLOGY, 19(1), 4–23.

Expression and ecdysteroid responsiveness of the nuclear receptors HR3 and E75 in the crustacean Daphnia magna

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 315(1-2), 208–218.

Interactions of the crustacean nuclear receptors HR3 and E75 in the regulation of gene transcription

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 167(2), 268–278.

Intracellular Conversion of Environmental Nitrate and Nitrite to Nitric Oxide with Resulting Developmental Toxicity to the Crustacean Daphnia magna

PLoS ONE, 5(8), e12453.

Introduction to Biochemical and Molecular Methods in Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 15–28). Hoboken, NJ: Wiley.

Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex

BMC Genomics, 10(1), 500.

Interactions of methyl farnesoate and related compounds with a crustacean retinoid X receptor

Molecular and Cellular Endocrinology, 309(1-2), 109–116.

Overview of Endocrine Disruptor Ecotoxicity in Wildlife

In C. Ethridge & J. Stevens (Eds.), Endocrine Toxicology (3rd ed., pp. 280–312). London: Informa Healthcare.

Predictive Modeling of a Mixture of Thyroid Hormone Disrupting Chemicals That Affect Production and Clearance of Thyroxine

INTERNATIONAL JOURNAL OF TOXICOLOGY, 28(5), 368–381.

Environmental cues trigger seasonal regression of primary and accessory sex organs of the mud snail, Ilyanassa obsoleta

JOURNAL OF MOLLUSCAN STUDIES, 74, 301–303.

Immunochemical Techniques in Toxicology

In E. Hodgson & R. C. Smart (Eds.), Molecular and Biochemical Toxicology (4th ed., pp. 109–128). Hoboken, New Jersey: John Wiley & Sons.

Synchronized expression of retinoid X receptor mRNA with reproductive tract recrudescence in an imposex-susceptible mollusc

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 42(4), 1345–1351.

The contribution of steroidal androgens and estrogens to reproductive maturation of the eastern mud snail Ilyanassa obsoleta

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 156(1), 15–26.

An ecological assessment of bisphenol-A: Evidence from comparative biology

[Review of ]. REPRODUCTIVE TOXICOLOGY, 24(2), 225–239.

Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure

Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure

Reproductive Toxicology, 24(2), 131–138.

Cloning and characterization of the retinoid X receptor from a primitive crustacean Daphnia magna

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 150(2), 309–318.

Crustacean endocrine toxicology: a review

[Review of ]. ECOTOXICOLOGY, 16(1), 61–81.

Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat

TOXICOLOGICAL SCIENCES, 97(1), 65–74.

Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition

TOXICOLOGICAL SCIENCES, 97(2), 512–519.

Testosterone and male fertility in red deer

The environmental-endocrine basis of gynandromorphism (intersex) in a crustacean

International Journal of Biological Sciences, 3(2), 77–84.

A candidate juvenoid hormone receptor cis-element in the Daphnia magna hb2 hemoglobin gene promoter

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 247(1-2), 91–102.

Atrazine stimulates hemoglobin accumulation in Daphnia magna: Is it hormonal or hypoxic?

TOXICOLOGICAL SCIENCES, 93(2), 443–449.

Chemical mixtures: Greater-than-additive effects?

Kinetic characterization of the inhibition of acyl coenzyme A: Steroid acyltransferases by tributyltin in the eastern mud snail (Ilyanassa obsoleta)

AQUATIC TOXICOLOGY, 78(3), 233–242.

A comparative study on androgen metabolism in three invertebrate species

General and Comparative Endocrinology, 143(3), 211–221.

A comparative study on androgen metabolism in three invertebrate species

General and Comparative Endocrinology, 143(3), 211–221.

An integrated addition and interaction model for assessing toxicity of chemical mixtures

TOXICOLOGICAL SCIENCES, 87(2), 520–528.

Androgen metabolism in invertebrates and its modulation by xenoandrogens - A comparative study

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY, Vol. 1040, pp. 354–356.

Covert signal disruption: Anti-ecdysteroidal activity of bisphenol a involves cross talk between signaling pathways

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 24(1), 146–152.

Joint action of polycyclic aromatic hydrocarbons: Predictive modeling of sublethal toxicity

AQUATIC TOXICOLOGY, 75(3), 253–262.

Stress signaling: coregulation of hemoglobin and male sex determination through a terpenoid signaling pathway in a crustacean

JOURNAL OF EXPERIMENTAL BIOLOGY, 208(1), 15–23.

Testosterone conjugating activities in invertebrates: are they targets for endocrine disruptors?

AQUATIC TOXICOLOGY, 71(3), 273–282.

Testosterone-fatty acid esterification: A unique target for the endocrine toxicity of tributyltin to gastropods

LeBlanc, G. A., Gooding, M. P., & Sternberg, R. M. (2005, February). INTEGRATIVE AND COMPARATIVE BIOLOGY, Vol. 45, pp. 81–87.

The screening of chemicals for juvenoid-related endocrine activity using the water flea Daphnia magna

AQUATIC TOXICOLOGY, 74(3), 193–204.

Toxicity Assessment of Environmentally Relevant Pollutant Mixtures Using a Heuristic Model

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, 1(2), 114–122.

Acute Toxicity

In A Textbook of Modern Toxicology (pp. 213–224).

Basics of Environmental Toxicology

In A Textbook of Modern Toxicology (pp. 463–478).

Cross communication between signaling pathways: Juvenoid hormones modulate ecdysteroid activity in a crustacean

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY, 301A(10), 793–801.

Elimination of Toxicants

In A Textbook of Modern Toxicology (pp. 203–211).

Endocrine System

In A Textbook of Modern Toxicology (pp. 299–315).

Evaluating the toxicity of chemical mixtures

LeBlanc, G. A., & Olmstead, A. W. (2004, September).

Interactive effects of vinclozolin and testosterone propionate on pregnancy and sexual differentiation of the male and female SD Rat

TOXICOLOGICAL SCIENCES, 78(1), 135–143.

Introduction to Biochemical and Molecular Methods in Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (pp. 13–22).

Non-target toxicology of a new mosquito larvicide, trypsin modulating oostatic factor

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 80(3), 131–142.

Seasonal variation in the regulation of testosterone levels in the eastern mud snail (Ilyanassa obsoleta)

Invertebrate Biology, 123(3), 237–243.

Synergistic interaction of endocrine-disrupting chemicals: Model development using an ecdysone receptor antagonist and a hormone synthesis inhibitor

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 23(4), 1085–1091.

Insecticidal juvenile hormone analogs stimulate the production of male offspring in the crustacean Daphnia magna

ENVIRONMENTAL HEALTH PERSPECTIVES, 111(7), 919–924.

The biocide tributyltin reduces the accumulation of testosterone as fatty acid esters in the mud snail (Ilyanassa obsoleta)

ENVIRONMENTAL HEALTH PERSPECTIVES, 111(4), 426–430.

The influence of speciation on the toxicity of silver to fathead minnows (Pimephales promelas)

In J. W. Gorsuch, J. R. Kramer, & T. W. LaPoint (Eds.), Silver : environmental transport, fate, effects, and models : papers from Environmental toxicology and chemistry, 1983 to 200 (pp. 313–322). Pensacola, FL: SETAC.

Abstracts from the Eleventh International Symposium on Pollutant Responses in Marine Organisms (PRIMO 11) - Endocrine disrupters

Marine Environmental Research, 54(3-5), 741–754.

Biological Processes

In A. W. Andren & T. W. Bober (Eds.), Silver in the Environment: Transport, Fate and Effects (pp. 65–96). Pensacola, FL: SETAC Press.

Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 129(2), 127–133.

Effects of prenatal testosterone propionate on the sexual development of male and female rats: A dose-response study

TOXICOLOGICAL SCIENCES, 65(1), 71–86.

Environmental antiecdysteroids alter embryo development in the crustacean Daphnia magna

JOURNAL OF EXPERIMENTAL ZOOLOGY, 292(3), 287–292.

Juvenoid hormone methyl farnesoate is a sex determinant in the crustacean Daphnia magna

JOURNAL OF EXPERIMENTAL ZOOLOGY, 293(7), 736–739.

Alterations in sexually dimorphic biotransformation of testosterone in juvenile American alligators (Alligator mississippiensis) from contaminated lakes

ENVIRONMENTAL HEALTH PERSPECTIVES, 109(12), 1257–1264.

Biotransformation and disposition of testosterone in the eastern mud snail Ilyanassa obsoleta

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 122(2), 172–180.

Conjugation and Elimination of Toxicants

In E. Hodgson & R. C. Smart (Eds.), Introduction to Biochemical Toxicology (3rd ed., pp. 115–136). New York: Wiley.

Immunochemical Techniques in Toxicology

In E. Hodgson & R. C. Smart (Eds.), Introduction to Biochemical Toxicology (3rd ed., pp. 33–50). New York: Wiley.

Low Exposure Concentration Effects of Methoprene on Endocrine-Regulated Processes in the Crustacean Daphnia magna

Toxicological Sciences, 62(2), 268–273.

Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland

BIOLOGY OF REPRODUCTION, 65(5), 1496–1505.

Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: II. Effects on male puberty and the reproductive tract

BIOLOGY OF REPRODUCTION, 65(5), 1506–1517.

Temporal and quantitative changes in sexual reproductive cycling of the cladoceran Daphnia magna by a juvenile hormone analog

JOURNAL OF EXPERIMENTAL ZOOLOGY, 290(2), 148–155.

The fungicide propiconazole interferes with embryonic development of the crustacean Daphnia magna

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 20(3), 502–509.

Changes in the metabolic elimination profile of testosterone following exposure of the crustacean Daphnia magna to tributyltin

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 45(3), 296–303.

Characterization of the period of sensitivity of fetal male sexual development to vinclozolin

TOXICOLOGICAL SCIENCES, 55(1), 152–161.

Effects of endocrine-active chemicals on the development of sex characteristics of Daphnia magna

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 19(8), 2107–2113.

Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to the crustacean Daphnia magna

ENVIRONMENTAL HEALTH PERSPECTIVES, 108(12), 1133–1138.

Fathead minnow vitellogenin: Complementary DNA sequence and messenger RNA and protein expression after 17 beta-estradiol treatment

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 19(4), 972–981.

Organochlorine bioaccumulation and risk for whales in a northwest Atlantic food web

Marine Environmental Research, 50(1-5), 440–441.

Petroleum pollution

Reviews in Toxicology, 3, 77–112.

Steroid hormone-regulated processes in invertebrates and their susceptibility to environmental endocrine disruption

In L. Guillette Jr. & D. A. Crain (Eds.), Environmental Endocrine Disrupters: An Evolutionary Perspective (pp. 126–154).

The contribution of hepatic inactivation of testosterone to the lowering of serum testosterone levels by ketoconazole

Toxicological Sciences, 54(1), 128–137.

Alteration in sexually dimorphic testosterone biotransformation profiles as a biomarker of chemically induced androgen disruption in mice

ENVIRONMENTAL HEALTH PERSPECTIVES, 107(5), 377–384.

Fathead minnow (Pimephales promelas) vitellogenin: purification, characterization and quantitative immunoassay for the detection of estrogenic compounds

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 123(2), 113–125.

Imposex in three marine gastropod species in Chile and potential impact on muriciculture

MARINE POLLUTION BULLETIN, 38(12), 1227–1231.

Molt-independent growth inhibition of Daphnia magna by a vertebrate antiandrogen

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 18(7), 1450–1455.

Screening approaches for the evaluation of endocrine disruption in invertebrates

In D. Henshel, M. Harrass, & M. Black (Eds.), Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for Endocrine Disruption and Environmental Assessment (Vol. 8, pp. 3–23).

The endocrinology of invertebrates

In M. Crane, P. L. deFur, C. Ingersoll, & L. Tattersfield (Eds.), Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment (pp. 23–106). Pensacola, FL: SETAC Press.

Workshop on Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment (EDIETA): Executive Summary

In M. Crane, P. L. DeFur, C. Ingersoll, & L. Tattersfield (Eds.), Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment. Pensacola, FL: SETAC Press.

Alteration of [C-14]-testosterone metabolism after chronic exposure of Daphnia magna to tributyltin

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 34(1), 21–25.

Altered metabolic elimination of testosterone and associated toxicity following exposure of Daphnia magna to nonylphenol polyethoxylate

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 39(2), 104–111.

Bioaccumulation

In P. Wexler (Ed.), Encyclopedia of Toxicology (Vol. 1, p. 148). New York: Academic Press Inc.

Endosulfan elevates testosterone biotransformation and clearance in CD-1 mice

TOXICOLOGY AND APPLIED PHARMACOLOGY, 148(1), 158–168.

Heat resistance of Alicyclobacillus acidoterrestris spores as affected by various pH values and organic acids

JOURNAL OF FOOD PROTECTION, 61(1), 41–46.

Involvement of multiple biotransformation processes in the metabolic elimination of testosterone by juvenile and adult fathead minnows (Pimephales promelas)

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 112(1), 69–79.

Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife

[Review of ]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 17(1), 68–87.

The state of the debate

Forum for Applied Research and Public Policy, 13(3), 6–10.

Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype

JOURNAL OF NATURAL PRODUCTS, 61(1), 112–115.

At the cutting edge - Pesticides: Multiple mechanisms of demasculinization

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 126(1), 1–5.

Basics of Environmental Toxicology

In E. Hodgson & P. E. Levi (Eds.), A Textbook of Modern Toxicology (2nd ed., pp. 389–406). Stamford, CT: Appleton & Lange.

Chemical contamination affects wildlife

In C. P. Cozic (Ed.), Garbage & Waste (pp. 92–95). San Diego, California: Greenhaven Press, Inc.

Chronic toxicity of environmental contaminants: Sentinels and biomarkers

Environmental Health Perspectives, 105(Suppl. 1), 65–80.

Elimination of Toxicants

In E. Hodgson & P. E. Levi (Eds.), A Textbook of Modern Toxicology (2nd ed., pp. 107–118). Stamford, CT: Appleton & Lange.

Invertebrates as sentinels of xenobiotic-induced endocrine disruption

In P. Guttry (Ed.), Endocrine Disruptors: Advances in Measuring and Analyzing Their Effects (pp. 1–24). Southborough, MA: International Business Communications.

Metabolic androgenization of female Daphnia magna by the xenoestrogen 4-nonylphenol

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 16(9), 1905–1911.

Reversal of multidrug resistance by derivatives of acrivastine: a study of structure activity relationships of P glycoprotein inhibitors in vitro and in vivo

Oncology Reports, 4(6), 1353–1360.

Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein

ENVIRONMENTAL HEALTH PERSPECTIVES, 105(8), 812–818.

Expression and induction of an immunochemically related class of glutathione S-transferases in Daphnia magna

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 113(2), 261–267.

Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein

Toxicology and Applied Pharmacology, 141(1), 288–298.

Mobilization of Pentachlorophenol by GlutathioneS-Transferase μ Increases Cellular Toxicity

Pesticide Biochemistry and Physiology, 54(1), 65–72.

Overexpression of ap-glycoprotein in hepatocellular carcinomas from woodchuck hepatitis virus-infected woodchucks (Marmota monax)

Hepatology, 23(4), 662–668.

Reductions in steroid hormone biotransformation/elimination as a biomarker of pentachlorophenol chronic toxicity

Aquatic Toxicology, 34(4), 291–303.