Works (196)

Updated: April 3rd, 2024 22:18

2023 book edited

Everyday Chemicals

By: G. LeBlanc*

Sources: Crossref, NC State University Libraries
Added: November 8, 2023

2022 journal article

Ignored microplastic sources from plastic bottle recycling

SCIENCE OF THE TOTAL ENVIRONMENT, 838.

By: Y. Guo*, X. Xia*, J. Ruan*, Y. Wang*, J. Zhang*, G. LeBlanc n, L. An*

author keywords: Post-consumer PET bottles; PET flake; Microplastics; Wet crush; Recycling
MeSH headings : Environmental Monitoring; Microplastics; Plastics; Polyethylene Terephthalates; Sewage; Wastewater / analysis; Water Pollutants, Chemical / analysis
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2022 journal article

Organotins in a food web from the Three Gorges Reservoir, China: Trophic enrichment and potential health risk

SCIENCE OF THE TOTAL ENVIRONMENT, 845.

By: J. You*, J. Gao*, P. Fu*, G. LeBlanc n, J. Guo*, L. Zhang*, M. Li*

author keywords: Organotin; Food web; Bioaccumulation; Trophic enrichment; Health risk
MeSH headings : Animals; China; Environmental Monitoring / methods; Food Chain; Organotin Compounds; Rivers; Water; Water Pollutants, Chemical / analysis
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 3, 2022

2021 review

A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology

[Review of ]. FRONTIERS IN ENDOCRINOLOGY, 12.

By: T. Knigge*, G. LeBlanc n & A. Ford*

author keywords: endocrine disruption; neuroendocrine disruption; ecdysteroid signaling; color change; sexual differentiation
MeSH headings : Animals; Biological Evolution; Crustacea / classification; Crustacea / drug effects; Crustacea / genetics; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Endocrine System / embryology; Endocrine System / growth & development; Fishes / classification; Molting / drug effects; Molting / physiology; Reproduction / drug effects; Water Pollutants, Chemical / toxicity
TL;DR: An overview of the evolution of the endocrine system of crustaceans is presented, endocrine endpoints known to be a target of disruption by chemicals are highlighted, and other components of endocrine signaling that may prove to be targets of disruption are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

A proposed nomenclature for microplastic contaminants

MARINE POLLUTION BULLETIN, 172.

By: W. Shi*, T. Cui*, H. Wu*, G. LeBlanc n, F. Wang* & L. An*

author keywords: Plastic particles; Particle size; Salt solution; Density; Standard format
MeSH headings : Environmental Monitoring; Microplastics; Plastics; Research Design; Water Pollutants, Chemical / analysis
TL;DR: A nomenclature is proposed that provides key information relating to the microplastics abundance in samples that would facilitate comparisons among studies to avoid over- or under-estimation of global microplastic levels and facilitate the interpretation of meta-data in future assessments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021

2020 journal article

An effective method for evaluation of microplastic contaminant in gastropod from Taihu Lake, China

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 27(18), 22878–22887.

By: Q. Xu*, T. Deng*, G. LeBlanc n & L. An*

author keywords: Polymer; Microplastics; mu-FT-IR; Gastropod; Digestion
MeSH headings : Animals; China; Environmental Monitoring; Lakes; Microplastics; Plastics; Water Pollutants, Chemical / analysis
TL;DR: A quick method was developed for the isolation and identification of microplastics from gastropod tissues, and the application of the method revealed the presence ofmicroplastics in snails inhabiting Taihu Lake, China. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020

2020 journal article

Endocrine Disruption in Invertebrates: A Survey of Research Progress

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(21), 13365–13369.

By: A. Ford* & G. LeBlanc n

MeSH headings : Animals; Ecosystem; Endocrine Disruptors / analysis; Endocrine Disruptors / toxicity; Endocrine System; Invertebrates; Surveys and Questionnaires; Vertebrates
TL;DR: Experts in this field were surveyed on the current state of the science and many of the recommendations matched those made over two decades ago, indicating that the field has not advanced as much as one might have expected. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 1, 2021

2020 journal article

Investigation of the microplastics profile in sludge from China's largest Water reclamation plant using a feasible isolation device

JOURNAL OF HAZARDOUS MATERIALS, 388.

author keywords: Sewage sludge; Isolation device; Source; Risk; Solutions
TL;DR: An effective isolation device, consisting of a fritted glass funnel and a glass filtration apparatus, was constructed to extract microplastics from sludge with nearly 100% recovery efficiency and revealed that domestic applications and vehicle products were the major sources of microplastic in sewage treatment sludge. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2020 journal article

Involvement of glutamate and serotonin transmitter systems in male sex determination in Daphnia pulex

JOURNAL OF INSECT PHYSIOLOGY, 121.

By: A. Camp n, J. Yun n, S. Chambers n, M. Haeba n & G. LeBlanc n

author keywords: Environmental sex determination; Endocrine cascade; Juvenile hormones; Zooplankton; Abiotic stimuli; N-methyl-D-aspartate receptor
MeSH headings : Animals; Daphnia / genetics; Daphnia / metabolism; Daphnia / physiology; Environment; Gene Expression; Glutamic Acid / genetics; Glutamic Acid / metabolism; Male; Neurotransmitter Agents / genetics; Neurotransmitter Agents / metabolism; Receptors, N-Methyl-D-Aspartate / agonists; Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate / metabolism; Seasons; Serotonin / genetics; Serotonin / metabolism; Sex Determination Processes / genetics; Sex Determination Processes / physiology; Signal Transduction
TL;DR: Evidence is provided that glutamatergic and serotonergic systems function upstream of the endocrine regulation of male sex determination in early life stage daphnids. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020

2020 journal article

Phthalate Esters and Their Potential Risk in PET Bottled Water Stored under Common Conditions

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 17(1).

By: X. Xu*, G. Zhou*, K. Lei*, G. LeBlanc n & L. An*

author keywords: PET bottles; contained water; PAEs; migration; health risk
MeSH headings : Beijing; Drinking Water / analysis; Endocrine Disruptors / toxicity; Esters / analysis; Esters / toxicity; Phthalic Acids / toxicity; Polyethylene Terephthalates / analysis; Polyethylene Terephthalates / toxicity
TL;DR: The results suggest that a part of the PAEs in PET bottled water originated from plastic bottles, which was related to the storage time and temperature, and Interestingly, DBP mainly contributed to the increased PAEs levels in simulation water. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2019 weblog post

Being certain about uncertainty

Le Blanc, G. A. (2019, July 2). https://news.ncsu.edu/2019/07/being-certain-about-uncertainty/

By: G. Le Blanc

Source: NC State University Libraries
Added: October 30, 2020

2019 journal article

Complementary roles of photoperiod and temperature in environmental sex determination in Daphnia spp.

The Journal of Experimental Biology, 222(4), jeb195289.

By: A. Camp n, M. Haeba n & G. LeBlanc n

author keywords: Zooplankton; Endocrine cascade; Methyl farnesoate receptor; Juvenoids; Methyl farnesoate
MeSH headings : Animals; Arthropod Proteins / genetics; Arthropod Proteins / metabolism; Daphnia / genetics; Daphnia / growth & development; Gene Expression Profiling; Gene Expression Regulation; Hot Temperature; Male; Photoperiod; Sex Determination Processes; Signal Transduction; Species Specificity
TL;DR: It is indicated that male sex determination in daphnids is under the permissive control of photoperiod and the regulatory control of temperature, which may act by increasing levels of the Met subunit of the methyl farnesoate receptor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 18, 2019

2019 journal article

Freshwater snail Parafossarulus striatulus estrogen receptor: Characteristics and expression profiles under lab and field exposure

CHEMOSPHERE, 220, 611–619.

By: F. Ma*, X. Han*, L. An*, K. Lei*, H. Qi* & G. LeBlanc n

author keywords: Freshwater snail; Endocrine disrupting chemicals; Mode of action; Estrogen receptor orthologue; RACE
MeSH headings : Animals; China; DNA, Complementary; Endocrine Disruptors / toxicity; Estradiol / pharmacology; Female; Lakes; Male; Methyltestosterone / pharmacology; Mollusca / chemistry; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Snails / chemistry; Transcription, Genetic; Transcriptome; Vitellogenins / genetics
TL;DR: The estrogen receptor (ER) of the mollusk Parafossarulus striatulus was identified and partially characterised and a significant elevation in vitellogenin transcription as compared to snails held at site SZ, suggesting that viteLLogenin production may be directly regulated by psER or co-regulated with psER in this species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2019

2019 journal article

The role of nuclear receptor E75 in regulating the molt cycle of Daphnia magna and consequences of its disruption

PLOS ONE, 14(8), e0221642.

By: S. Street n, S. Eytcheson n & G. LeBlanc n

Ed(s): C. Englert

MeSH headings : Animals; Daphnia / drug effects; Daphnia / metabolism; Daphnia / physiology; Gene Expression Regulation, Developmental / drug effects; Models, Biological; Molting / drug effects; Molting / genetics; Molting / physiology; Nitroprusside / pharmacology; RNA Interference; RNA, Double-Stranded / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear / metabolism; Signal Transduction / drug effects
TL;DR: It is concluded that the molt cycle of daphnids is regulated in a manner similar to insects and disruption of E75 results in a lengthening of themolt cycle and a reduction the release of viable offspring. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019

2018 journal article

Hemoglobin Levels Modulate Nitrite Toxicity to Daphnia magna

Scientific Reports, 8(1).

By: S. Eytcheson n & G. LeBlanc n

MeSH headings : Animals; Copper / toxicity; Daphnia / drug effects; Daphnia / genetics; Hemoglobins / genetics; Hemoglobins / metabolism; Nitrates / metabolism; Nitrates / toxicity; Nitrites / metabolism; Nitrites / toxicity; Pyridines / pharmacology; Pyridines / toxicity; RNA, Small Interfering / genetics; Reproduction / drug effects; Reproduction / genetics; Water Pollutants, Chemical / toxicity
TL;DR: Results indicate that increased hemoglobin levels increase the tolerance of daphnids to nitrite toxicity which may serve to protect daphNids in environments subject to hemoglobin-elevating hypoxia or elevated temperatures. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2018 magazine article

New method lights the way for future toxicity testing

Le Blanc, G. A. (2018, January). Euro Cosmetics, (26).

By: G. Le Blanc

Source: NC State University Libraries
Added: October 30, 2020

2018 journal article

No impacts of microcystins on wild freshwater snail Bellamya Aeruginosa fecundity from a eutrophic lake

Environmental Toxicology and Pharmacology, 60, 165–168.

By: F. Qiao*, K. Lei*, X. Han*, Z. Wei*, X. Zhao*, L. An*, G. LeBlanc n

author keywords: Eutrophication; Microcystin; Freshwater snail; Fecundity
MeSH headings : Animals; Eutrophication; Fertility / drug effects; Lakes; Microcystins / toxicity; Snails / drug effects; Snails / physiology; Water Pollutants, Chemical / toxicity
TL;DR: The preliminary investigation at shoreline along Taihu lake with different degrees of eutrophication status found no significant relationship between the microcystin-LR concentrations and the freshwater snail Bellamya aeruginosa fecundity or the abundance of wild freshwater snails. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Agonist-mediated assembly of the crustacean methyl farnesoate receptor

Scientific Reports, 7(1).

By: E. Kakaley n, H. Wang n & G. LeBlanc n

MeSH headings : Animals; Crustacea; Fatty Acids, Unsaturated / metabolism; Gene Expression; Models, Biological; Nuclear Receptor Coactivators / chemistry; Nuclear Receptor Coactivators / genetics; Nuclear Receptor Coactivators / metabolism; Protein Binding; Protein Multimerization; Protein Subunits / agonists; Protein Subunits / chemistry; Protein Subunits / genetics
TL;DR: Results demonstrated that the Met subunit is highly dynamic in controlling the action of methyl farnesoate through temporal variation in its expression and availability for receptor assembly. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Ligand-Mediated Receptor Assembly as an End Point for High-Throughput Chemical Toxicity Screening

Environmental Science & Technology, 51(16), 9327–9333.

MeSH headings : Animals; Daphnia; Energy Transfer; Genes, Reporter; Ligands; Reproduction; Toxicity Tests; Water Pollutants, Chemical / toxicity
TL;DR: The BRET assay is an accurate, sensitive, and cost/time efficient alternative to traditional screening assays for ligand-mediated receptor assembly and its application to the screening of chemicals for interaction with targeted receptors. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Preliminary evidence for snail deformation from a Eutrophic lake

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 53, 219–226.

By: K. Lei*, F. Qiao*, Q. Liu*, Z. Wei*, L. An*, H. Qi*, S. Cui*, G. LeBlanc n

author keywords: Eutrophication; Snail; Deformity; Transcriptomic; Mechanism
MeSH headings : Animals; China; Chlorophyll / analysis; Chlorophyll A; Congenital Abnormalities; Eutrophication; Female; Gene Expression Profiling; Lakes / chemistry; Snails / anatomy & histology; Snails / genetics
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 weblog post

The value of science is reflected in your everyday decisions

Le Blanc, G. A. (2017, March 31). https://news.ncsu.edu/2017/03/the-value-of-science-leblanc-2017/

By: G. Le Blanc

Source: NC State University Libraries
Added: October 30, 2020

2017 journal article

Validation of a two-generational reproduction test in Daphnia magna: An interlaboratory exercise

Science of The Total Environment, 579, 1073–1083.

By: C. Barata*, B. Campos*, C. Rivetti*, G. LeBlanc n, S. Eytcheson n, S. McKnight n, M. Tobor-Kaplon*, S. de Vries Buitenweg* ...

author keywords: Daphnia reproduction; Multigeneration assay; Interlaboratory; OECD 211; Contaminants; Life-history; Offspring quality
MeSH headings : Animals; Daphnia / physiology; Fertility; Reproduction / drug effects; Toxicity Tests / methods; Water Pollutants, Chemical / toxicity
TL;DR: Results suggest that the proposed assay is reproducible but cumulative toxicity in the second generation cannot reliably be detected with this assay. (via Semantic Scholar)
Source: Crossref
Added: January 28, 2020

2017 journal article

Validation of a two-generational reproduction test in Daphnia magna: an interlaboratory exercise

Science of the Total Environment, 579, 1073–1083.

By: C. Barata, B. Campos, C. Rivetti, G. LeBlanc, S. Eytcheson, S. McKnight, M. Tobor-Kaplon, S. Buitenweg ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Differential Interactions of the Flame Retardant Triphenyl Phosphate within the PPAR Signaling Network

MOJ Toxicology, 2(3).

By: G. Le Blanc

Sources: Crossref, NC State University Libraries
Added: September 28, 2019

2016 journal article

Retrospective: Acute Toxicity of Priority Pollutants

Bulletin of Environmental Contamination and Toxicology, 97(3), 301–302.

By: G. LeBlanc n

TL;DR: This study reveals that most of the chlorobenzenes, chlorophenols, and metal salts evaluated were highly toxic to daphnids, while compounds including fluoride, benzene, fluoranthene, toluene, and barium proved to have low acute toxicity using the toxicity ranking system provided by the National Research Council. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2016 content posted

Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing

By: V. Wilson*, G. LeBlanc n, S. Kullman n, K. Crofton*, P. Schmieder* & M. Jacobs*

TL;DR: Challenges and the future of endocrine disrupting compound screening and testing and running head: Future challenges for EDC screenings and testing. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2015 journal article

Estimation of time-varying mortality rates using continuous models for Daphnia magna

APPLIED MATHEMATICS LETTERS, 44, 12–16.

By: K. Adoteye n, H. Banks n, K. Flores n & G. LeBlanc n

author keywords: Structured population model; Leslie matrix model; Sinko-Streifer model; Daphnia magna; Time-dependent mortality rate
TL;DR: It is found that a continuous differential equation model with a time-varying mortality rate was the most accurate model for describing the authors' experimental D. magna survival data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 review

Males on demand: the environmental-neuro-endocrine control of male sex determination in daphnids

[Review of ]. FEBS JOURNAL, 282(21), 4080–4093.

By: G. LeBlanc n & E. Medlock n

author keywords: doublesex; epigenetic; farnesoic acid O-methyltransferase; NMDA receptor; nutrition; parthenogenesis; photoperiod; sex lethal; temperature; transformer
MeSH headings : Animals; Daphnia / genetics; Daphnia / growth & development; Daphnia / physiology; Environment; Fatty Acids, Unsaturated / physiology; Female; Food; Male; Models, Biological; Neurosecretory Systems / physiology; Parthenogenesis / genetics; Parthenogenesis / physiology; Phenotype; Population Density; Seasons; Sex Determination Processes / genetics; Sex Determination Processes / physiology; Signal Transduction
TL;DR: This review describes the cascade of events beginning with environmental cues and ending with changes in gene expression that dictate male sex determination in daphnids, the initial event in the switch to sexual reproduction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Short-term fish reproduction assays with methyl tertiary butyl ether with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity

Environmental Toxicology and Chemistry, 34(9), 2013–2022.

By: E. Mihaich, S. Erler*, G. Le Blanc n & S. Gallagher

author keywords: Methy-tert-butyl ether (MTBE); Endocrine disruptor; Fish short-term reproduction assay; Aquatic toxicology
MeSH headings : Animals; Cyprinidae / growth & development; Cyprinidae / physiology; Endocrine System / drug effects; Endocrine System / metabolism; Enzyme-Linked Immunosorbent Assay; Female; Fertility; Male; Methyl Ethers / chemistry; Methyl Ethers / toxicity; Reproduction / drug effects; Vitellogenins / blood; Water Pollutants, Chemical / chemistry; Water Pollutants, Chemical / toxicity; Zebrafish / growth & development; Zebrafish / physiology
TL;DR: The results of these 2 guideline studies indicate that MTBE does not interact with the hypothalamic–pituitary–gonadal axis of zebrafish or fathead minnow. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: November 17, 2019

2015 journal article

Statistical validation of structured population models for Daphnia magna

Mathematical Biosciences, 266, 73–84.

By: K. Adoteye n, H. Banks n, K. Cross n, S. Eytcheson n, K. Flores n, G. LeBlanc n, T. Nguyen n, C. Ross n ...

author keywords: Sensitivity analysis; Structured population model; Uncertainty quantification; Density-dependence; Multi-scale data; Daphnia magna
MeSH headings : Animals; Daphnia; Models, Statistical; Population Dynamics
TL;DR: This study develops structured population models that exemplify specific mechanisms and uses multi-scale experimental data in order to test their importance, and shows that fecundity and survival rates are affected by both time-varying density-independent factors and density-dependent factors. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Endocrine regulation of predator-induced phenotypic plasticity

Oecologia, 176(3), 625–635.

By: S. Dennis*, G. LeBlanc n & A. Beckerman*

MeSH headings : Animals; Daphnia / anatomy & histology; Daphnia / genetics; Daphnia / growth & development; Daphnia / physiology; Ecdysone / metabolism; Endocrine System / metabolism; Food Chain; Gene Expression Regulation; Juvenile Hormones / metabolism; Phenotype; Real-Time Polymerase Chain Reaction
TL;DR: This research synthesizes detail about predator-induced defenses and the physiological regulation of arthropod somatic growth and morphology, leading to a clear prediction that morphological defences are regulated by juvenile hormone and life-history plasticity by ecdysone and juvenile hormone. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Estrogen alters the profile of the transcriptome in river snail Bellamya aeruginosa

Ecotoxicology, 24(2), 330–338.

By: K. Lei*, R. Liu*, L. An*, Y. Luo* & G. LeBlanc n

author keywords: Bellamya aeruginosa; Transcriptome; 454 sequencing; GO; Estrogen
MeSH headings : Animals; Estradiol / toxicity; Estrogens / toxicity; Molecular Sequence Data; Snails / drug effects; Snails / genetics; Transcriptome / drug effects; Water Pollutants, Chemical / toxicity
TL;DR: Significant differences were found in gene expression in both liver and testicular tissues between control and E2-exposed organisms, which will help in understanding the molecular mechanisms of the response to physiological stress in the river snail exposed to estrogen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

A Transgenerational Endocrine Signaling Pathway in Crustacea

PLoS ONE, 8(4), e61715.

By: G. LeBlanc n, Y. Wang n, C. Holmes n, G. Kwon n & E. Medlock n

Ed(s): B. He

MeSH headings : Amino Acid Sequence; Animals; Cloning, Molecular; Crustacea / drug effects; Crustacea / metabolism; Daphnia / drug effects; Daphnia / physiology; Endocrine System / drug effects; Endocrine System / metabolism; Fatty Acids, Unsaturated / pharmacology; Female; Fertility; Genes, Reporter; Life Cycle Stages / drug effects; Ligands; Luciferases / metabolism; Male; Molecular Sequence Data; Population Density; Pyridines / pharmacology; Sex Determination Processes / drug effects; Sex Ratio; Signal Transduction / drug effects; Transcription Factors / chemistry
TL;DR: Results reveal likely components to a hormone/receptor signaling pathway in a crustacean that orchestrates transgenerational modifications to important population metrics (sex ratios, fecundity of females) and how these signaling processes can facilitate population sustainability under normal conditions or threaten sustainability when perturbed by environmental chemicals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 report

Detailed review paper on the state of the science on novel in vitro and in vivo screening and testing methods and endpoints for evaluating endocrine disruptors

(Series on Testing & Assessment No. 178). Organization for Economic Co-operation and Development.

By: G. Le Blanc, S. Kullman, D. Norris, W. Baldwin, K. W. & J. Greally

Source: NC State University Libraries
Added: August 8, 2021

2011 journal article

Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna)

AQUATIC TOXICOLOGY, 101(2), 351–357.

By: B. Hannas n, Y. Wang n, S. Thomson n, G. Kwon n, H. Li n & G. LeBlanc n

author keywords: Vitellogenin; Water flea; Biomarker; Ecdysteroids; Estrogens; Endocrine disruption
MeSH headings : Animals; Cadmium / toxicity; Daphnia / drug effects; Daphnia / genetics; Daphnia / metabolism; Ecdysteroids / toxicity; Ecdysterone / toxicity; Environmental Pollutants / toxicity; Estrogens / toxicity; Gene Expression / drug effects; Heterocyclic Compounds / toxicity; Polycyclic Compounds / toxicity; RNA, Messenger / metabolism; Vitellogenins / genetics; Vitellogenins / metabolism; Xenobiotics / toxicity
TL;DR: Results indicate that ecdysteroids are suppressors of vitellogenin gene expression and that viteLLogenin mRNA levels can be elevated or suppressed in daphnids by xenobiotics that elicit antiecdysteroidal or ecdystersoidal activity, respectively. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Tributyltin Synergizes with 20-Hydroxyecdysone to Produce Endocrine Toxicity

TOXICOLOGICAL SCIENCES, 123(1), 71–79.

By: Y. Wang n, G. Kwon n, H. Li n & G. LeBlanc n

author keywords: chemical mixtures; models; synergy; invertebrate; ecdysteroid; nuclear receptor; retinoid X receptor; ecdysteroid receptor
MeSH headings : Animals; Cells, Cultured; Daphnia; Dose-Response Relationship, Drug; Drug Synergism; Ecdysterone / metabolism; Ecdysterone / toxicity; Female; Gene Expression / drug effects; Molting / drug effects; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Retinoid X Receptors / genetics; Retinoid X Receptors / metabolism; Signal Transduction; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
TL;DR: Results demonstrate that xenobiotics, such as tributyltin, can interact with RXR to influence gene expression regulated by the heterodimeric partner to RXR. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 chapter

Acute Toxicity

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 225–236). Hoboken, NJ: Wiley.

By: G. LeBlanc

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: March 18, 2021

2010 chapter

Elimination of Toxicants

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 213–222). Hoboken, NJ: Wiley.

By: G. Le Blanc

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: March 8, 2021

2010 chapter

Endocrine Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 345–362). Hoboken, NJ: Wiley.

By: G. LeBlanc

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: March 18, 2021

2010 review

Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs

[Review of ]. ECOTOXICOLOGY, 19(1), 4–23.

By: R. Sternberg n, M. Gooding n, A. Hotchkiss n & G. LeBlanc n

author keywords: Mollusk; Endocrinology; Tributyltin; Imposex; Retinoid X-receptor
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Female; Male; Models, Biological; Photoperiod; Retinoid X Receptors / metabolism; Sex Characteristics; Sex Differentiation / drug effects; Signal Transduction / drug effects; Snails / drug effects; Snails / physiology; Temperature; Tretinoin / metabolism; Trialkyltin Compounds / metabolism; Trialkyltin Compounds / toxicity
TL;DR: A cohesive model is provided for the environmental-endocrine regulation of reproduction in gastropods and it is proposed that TBT causes imposex through the inappropriate activation of this signaling pathway. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Expression and ecdysteroid responsiveness of the nuclear receptors HR3 and E75 in the crustacean Daphnia magna

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 315(1-2), 208–218.

By: B. Hannas n & G. LeBlanc n

author keywords: Nuclear receptor; Water flea; Molting; Ecdysis; Endocrine disruption
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Crustacea / genetics; Crustacea / physiology; Daphnia / genetics; Daphnia / physiology; Drosophila melanogaster / genetics; Ecdysteroids / metabolism; Ecdysterone / metabolism; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Molecular Sequence Data; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Sequence Alignment; Signal Transduction / physiology
TL;DR: Results are consistent with the premise that transcription of HR3 is regulated by ecdysteroids in the crustacean D. magna and that HR3 likely serves as a mediator of Ecdysteroid regulatory action in crustaceans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Interactions of the crustacean nuclear receptors HR3 and E75 in the regulation of gene transcription

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 167(2), 268–278.

By: B. Hannas n, Y. Wang n, W. Baldwin*, Y. Li*, A. Wallace n & G. LeBlanc n

author keywords: Daphnia pulex; Ecdysteroids; Endocrine disruptor; Nuclear receptors
TL;DR: The premise that HR3 is a major component of ecdysteroid signaling in some crustaceans and is under the negative regulatory control of E75 is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Intracellular Conversion of Environmental Nitrate and Nitrite to Nitric Oxide with Resulting Developmental Toxicity to the Crustacean Daphnia magna

PLoS ONE, 5(8), e12453.

By: B. Hannas n, P. Das n, H. Li n & G. LeBlanc n

Ed(s): X. Pan

MeSH headings : Animals; Animals, Newborn; Daphnia / cytology; Daphnia / drug effects; Daphnia / growth & development; Daphnia / metabolism; Drosophila / cytology; Drosophila / drug effects; Drosophila / metabolism; Ecdysteroids / metabolism; Ecosystem; Endocrine System / drug effects; Endocrine System / metabolism; Environmental Monitoring; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Female; Intracellular Space / drug effects; Intracellular Space / metabolism; Nitrates / metabolism; Nitrates / toxicity; Nitric Oxide / metabolism; Nitrites / metabolism; Nitrites / toxicity; Reproduction / drug effects; Risk
TL;DR: Results demonstrate that nitrite elicits developmental and reproductive toxicity at environmentally relevant concentrations due likely to its intracellular conversion to nitric oxide. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2010 chapter

Introduction to Biochemical and Molecular Methods in Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 15–28). Hoboken, NJ: Wiley.

By: E. Hodgson, G. Le Blanc, S. Meyer & R. Smart

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: March 8, 2021

2009 journal article

Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex

BMC Genomics, 10(1), 500.

By: S. Thomson n, W. Baldwin*, Y. Wang n, G. Kwon n & G. LeBlanc n

MeSH headings : Amino Acid Sequence; Animals; Daphnia / genetics; Daphnia / physiology; Evolution, Molecular; Female; Gene Expression Regulation; Genome; Humans; Molecular Sequence Data; Parthenogenesis / genetics; Phylogeny; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear / chemistry; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism
TL;DR: Putative nuclear receptors from the first assembled genome of a crustacean Daphnia pulex were identified to gain insight into evolution and function and contain the same degree of conservation that is typically found within nuclear receptors of other species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 17, 2019

2009 journal article

Interactions of methyl farnesoate and related compounds with a crustacean retinoid X receptor

Molecular and Cellular Endocrinology, 309(1-2), 109–116.

By: Y. Wang n & G. LeBlanc n

author keywords: RXR; EcR; Methyl farnesoate; Daphnia; Tributyltin
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; DNA, Complementary / genetics; DNA, Complementary / isolation & purification; Daphnia / drug effects; Daphnia / metabolism; Ecdysterone / pharmacology; Fatty Acids, Unsaturated / metabolism; Genes, Reporter; Humans; Ligands; Luciferases / metabolism; Male; Molecular Sequence Data; Open Reading Frames / genetics; Receptors, Steroid / metabolism; Retinoid X Receptors / chemistry; Retinoid X Receptors / genetics; Retinoid X Receptors / metabolism; Sequence Alignment; Sequence Homology, Amino Acid; Sex Determination Processes; Sex Ratio; Transcriptional Activation / drug effects
TL;DR: Results indicate that methyl farnesoate, along with compounds that are functionally similar to methyl farNESoate synergize with ecdysteroids to activate the RXR:EcR receptor complex, however, this effect appears to be unrelated to the ability of these compounds to stimulate male sex determination. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2009 chapter

Overview of Endocrine Disruptor Ecotoxicity in Wildlife

In C. Ethridge & J. Stevens (Eds.), Endocrine Toxicology (3rd ed., pp. 280–312). London: Informa Healthcare.

By: G. LeBlanc

Ed(s): C. Ethridge & J. Stevens

Source: NC State University Libraries
Added: March 18, 2021

2009 journal article

Predictive Modeling of a Mixture of Thyroid Hormone Disrupting Chemicals That Affect Production and Clearance of Thyroxine

INTERNATIONAL JOURNAL OF TOXICOLOGY, 28(5), 368–381.

By: J. Flippin n, J. Hedge n, M. DeVito n, G. LeBlanc n & K. Crofton n

author keywords: thyroid hormone disruption; mixture modeling; pronamide; mancozeb; thiram; polyhalogenated aromatic hydrocarbons
MeSH headings : Animals; Cytochrome P-450 CYP1A1 / metabolism; Cytochrome P-450 CYP2B1 / metabolism; Dose-Response Relationship, Drug; Endocrine Disruptors / chemistry; Endocrine Disruptors / toxicity; Female; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Models, Biological; Pesticides / chemistry; Pesticides / toxicity; Predictive Value of Tests; Rats; Rats, Long-Evans; Thyroid Gland / drug effects; Thyroid Gland / metabolism; Thyroxine / biosynthesis; Thyroxine / blood; Thyroxine / metabolism
TL;DR: The hypothesis that serum T4 concentrations of rodents exposed to a mixture of both TH synthesis inhibitors and stimulators of T4 clearance in the liver could be best predicted by an integrated addition model is tested and the use of dose- and integrated additivity models in predicting the effects of complex mixtures are supported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Environmental cues trigger seasonal regression of primary and accessory sex organs of the mud snail, Ilyanassa obsoleta

JOURNAL OF MOLLUSCAN STUDIES, 74, 301–303.

By: A. Hotchkiss*, R. Sternberg* & G. LeBlanc*

TL;DR: Whether the seasonal onset of regression in mud snails is controlled by two environmental cues, photoperiod or temperature is investigated, which is an accurate predictor of changing seasons. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 chapter

Immunochemical Techniques in Toxicology

In E. Hodgson & R. C. Smart (Eds.), Molecular and Biochemical Toxicology (4th ed., pp. 109–128). Hoboken, New Jersey: John Wiley & Sons.

By: G. LeBlanc

Ed(s): E. Hodgson & R. Smart

Source: NC State University Libraries
Added: March 18, 2021

2008 journal article

Synchronized expression of retinoid X receptor mRNA with reproductive tract recrudescence in an imposex-susceptible mollusc

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 42(4), 1345–1351.

By: R. Sternberg n, A. Hotchkiss n & G. Leblanc n

MeSH headings : Amino Acid Sequence; Animals; Female; Male; Molecular Sequence Data; Mollusca / anatomy & histology; Phylogeny; RNA, Messenger / genetics; Reproduction; Retinoid X Receptors / chemistry; Retinoid X Receptors / genetics; Sequence Homology, Amino Acid; Species Specificity
TL;DR: Results demonstrate that RXR expression is associated with reproductive tract recrudescence in both sexes; although, the timing of recrUDescence may dictate sex-specific development. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

The contribution of steroidal androgens and estrogens to reproductive maturation of the eastern mud snail Ilyanassa obsoleta

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 156(1), 15–26.

By: R. Sternberg*, A. Hotchkiss* & G. LeBlanc*

author keywords: androgens; estrogens; retinoids; neogastropod; gastropod; imposex; tributyltin; bisphenol A
MeSH headings : Amino Acid Sequence; Androgens / physiology; Animals; Estradiol / metabolism; Estrogens / physiology; Female; Male; Molecular Sequence Data; Phylogeny; RNA, Messenger / metabolism; Receptors, Androgen / metabolism; Receptors, Estrogen / analysis; Receptors, Estrogen / metabolism; Reproduction / physiology; Sexual Maturation / physiology; Snails / physiology; Testosterone / metabolism
TL;DR: In conclusion, testosterone may have a role in male reproductive tract recrudescence; however, this putative activity is independent of a NR3C4-type androgen receptor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 review

An ecological assessment of bisphenol-A: Evidence from comparative biology

[Review of ]. REPRODUCTIVE TOXICOLOGY, 24(2), 225–239.

By: D. Crain*, M. Eriksen, T. Iguchi, S. Jobling*, H. Laufer*, G. LeBlanc n, L. Guillette*

author keywords: bisphenol-A (BPA); wildlife; reproduction; environmental concentrations; vitellogenin; landfill leachate; spermatogenesis
MeSH headings : Animals; Benzhydryl Compounds; Ecology; Environmental Exposure / analysis; Environmental Monitoring / methods; Female; Humans; Male; Phenols / chemistry; Phenols / metabolism; Phenols / toxicity; Reproduction / drug effects; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR: A comparison of measured BPA environmental concentrations with chronic values suggests that no significant margin of safety exists for the protection of aquatic communities against the toxicity of BPA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure

Reproductive Toxicology, 24(2), 131–138.

By: F. vom Saal*, B. Akingbemi*, S. Belcher*, L. Birnbaum*, D. Crain*, M. Eriksen, F. Farabollini*, L. Guillette* ...

Contributors: F. Saal*, B. Akingbemi*, S. Belcher*, L. Birnbaum*, D. Crain*, M. Eriksen, F. Farabollini*, L. Guillette Jr. ...

author keywords: bisphenol A; in vitro; in vivo; rat; mouse; aquatic animal; cancer; low dose; non-monotonic dose-response curves; developmental programming
MeSH headings : Air Pollutants, Occupational / poisoning; Animals; Animals, Wild; Benzhydryl Compounds; Consensus; Dose-Response Relationship, Drug; Estrogens, Non-Steroidal / poisoning; Female; Humans; Male; Models, Animal; National Institutes of Health (U.S.); North Carolina; Phenols / poisoning; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment / methods; Risk Assessment / standards; United States; United States Environmental Protection Agency
TL;DR: This document is a summary statement of the outcome from he meeting: “Bisphenol A: An Examination of the Relevance of cological, In vitro and Laboratory Animal Studies for Assessng Risks to Human Health” sponsored by both the NIEHS and IDCR at NIH/DHHS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: March 8, 2020

2007 personal communication

Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure

Gerald LeBlanc; John G. Vandenbergh

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Cloning and characterization of the retinoid X receptor from a primitive crustacean Daphnia magna

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 150(2), 309–318.

By: Y. Wang n, G. Wang n & G. LeBlanc n

author keywords: crustacean; Daphnia; RXR; hormone; receptor; endocrine; sex determination
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA, Complementary / genetics; Daphnia / genetics; Daphnia / metabolism; Ecdysterone / pharmacology; Fatty Acids, Unsaturated / metabolism; Female; Gene Expression Regulation, Developmental / drug effects; Male; Molecular Sequence Data; Phylogeny; Pyridines / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Retinoid X Receptors / antagonists & inhibitors; Retinoid X Receptors / biosynthesis; Retinoid X Receptors / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment
TL;DR: Results show that branchiopod crustaceans dynamically express RXR which should be evaluated as a candidate receptor for the terpenoid hormone methyl farnesoate which functions as a sex determinant in these organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 review

Crustacean endocrine toxicology: a review

[Review of ]. ECOTOXICOLOGY, 16(1), 61–81.

By: G. LeBlanc n

author keywords: crustacean; endocrine; ecdysteroid; terpenoid; methyl farnesoate; intersex
MeSH headings : Animals; Crustacea / drug effects; Crustacea / physiology; Endocrine Disruptors / toxicity; Invertebrate Hormones / physiology; Water Pollutants, Chemical / toxicity
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat

TOXICOLOGICAL SCIENCES, 97(1), 65–74.

By: C. Blystone n, J. Furr*, C. Lambright*, K. Howdeshell*, B. Ryan*, V. Wilson*, G. LeBlanc n, L. Gray*

author keywords: prochloraz; testosterone; antiandrogen; puberty; Hershberger; steroidgenesis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; Androgen Antagonists / toxicity; Androgen Receptor Antagonists; Androgens / metabolism; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors / toxicity; Fungicides, Industrial / toxicity; Genitalia, Male / drug effects; Genitalia, Male / enzymology; Genitalia, Male / growth & development; Genitalia, Male / metabolism; Imidazoles / toxicity; Male; No-Observed-Adverse-Effect Level; Orchiectomy; Organ Size / drug effects; Progesterone / blood; Rats; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Sexual Development / drug effects; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / metabolism; Testosterone / blood; Testosterone / metabolism; Testosterone Propionate / pharmacology; Time Factors; Toxicity Tests / methods
TL;DR: The fact that hormone levels were affected at dosage eightfold below that which delayed the onset of puberty suggests that rather large reductions in serum testosterone may be required to delay puberty and consistently reduce androgen-dependent tissue weights. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition

TOXICOLOGICAL SCIENCES, 97(2), 512–519.

By: C. Blystone n, C. Lambright*, K. Howdeshell*, J. Furr*, R. Sternberg n, B. Butterworth*, E. Durhan*, E. Makynen* ...

author keywords: prochloraz; testosterone; CYP17; steroidogenesis; fetal testis
MeSH headings : 17-alpha-Hydroxyprogesterone / blood; 17-alpha-Hydroxyprogesterone / metabolism; Amniotic Fluid / metabolism; Androgen Receptor Antagonists; Androstenedione / blood; Androstenedione / metabolism; Animals; Body Weight / drug effects; Dose-Response Relationship, Drug; Estradiol / biosynthesis; Estradiol / blood; Female; Fetus / drug effects; Fetus / metabolism; Fungicides, Industrial / pharmacokinetics; Fungicides, Industrial / toxicity; Gene Expression / drug effects; Imidazoles / pharmacokinetics; Imidazoles / toxicity; Male; Phosphoproteins / biosynthesis; Pregnancy; Progesterone / biosynthesis; Progesterone / blood; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Rats; Steroid 17-alpha-Hydroxylase / antagonists & inhibitors; Steroid 17-alpha-Hydroxylase / biosynthesis; Steroid 17-alpha-Hydroxylase / genetics; Steroids / biosynthesis; Testis / drug effects; Testis / embryology; Testis / metabolism; Testosterone / biosynthesis; Testosterone / physiology
TL;DR: It is demonstrated that PCZ lowers testicular testosterone synthesis by inhibiting CYP17 activity which likely contributes to the induced malformations in androgen-dependent tissues of male offspring. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 personal communication

Testosterone and male fertility in red deer

By: G. LeBlanc

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

The environmental-endocrine basis of gynandromorphism (intersex) in a crustacean

International Journal of Biological Sciences, 3(2), 77–84.

By: A. Olmstead n & G. LeBlanc n

MeSH headings : Animals; Daphnia / physiology; Disorders of Sex Development / chemically induced; Disorders of Sex Development / epidemiology; Disorders of Sex Development / physiopathology; Environment; Fatty Acids, Unsaturated / metabolism; Female; Incidence; Male; Phenotype; Pyridines; Sex Determination Processes; Temperature
TL;DR: It is demonstrated that environmental factors can cause aberrant sex determination via perturbations in methyl farnesoate signaling and suggested that male sex determination normally occurs prior to the first embryonic cleavage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2006 journal article

A candidate juvenoid hormone receptor cis-element in the Daphnia magna hb2 hemoglobin gene promoter

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 247(1-2), 91–102.

By: T. Gorr*, C. Rider n, H. Wang n, A. Olmstead n & G. LeBlanc n

author keywords: methyl farnesoate; juvenoid; crustacean; response element; sex determination
MeSH headings : Animals; Base Sequence; Cycloheximide / pharmacology; Daphnia / genetics; Daphnia / physiology; Fatty Acids, Unsaturated / metabolism; Hemoglobins / biosynthesis; Hemoglobins / genetics; Hemoglobins / physiology; Juvenile Hormones / metabolism; Molecular Sequence Data; Promoter Regions, Genetic; Pyridines / metabolism; RNA, Messenger / biosynthesis; Receptors, Cytoplasmic and Nuclear / genetics; Receptors, Cytoplasmic and Nuclear / metabolism; Response Elements; Signal Transduction
TL;DR: Induction of hb2 by juvenoids was not dependent upon the synthesis of secondary transcription factors that bound the JRE but was likely due to activation of the gene directly by the juvenoid-receptor complex. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Atrazine stimulates hemoglobin accumulation in Daphnia magna: Is it hormonal or hypoxic?

TOXICOLOGICAL SCIENCES, 93(2), 443–449.

By: C. Rider n & G. LeBlanc n

author keywords: cumulative toxicity; terpenoids; mixture modeling; invertebrates; endocrine disruption
MeSH headings : Animals; Atrazine / toxicity; Daphnia / drug effects; Daphnia / metabolism; Dose-Response Relationship, Drug; Hemoglobins / genetics; Hemoglobins / metabolism; Herbicides / toxicity; Hypoxia-Inducible Factor 1 / physiology; Pyridines / toxicity; RNA, Messenger / analysis
TL;DR: Results from this study demonstrate that mixtures modeling can be used to assess a chemical's mechanism of action and that atrazine likely stimulates hemoglobin accumulation through the oxygen-sensing pathway. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 personal communication

Chemical mixtures: Greater-than-additive effects?

By: G. LeBlanc & G. Wang

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Kinetic characterization of the inhibition of acyl coenzyme A: Steroid acyltransferases by tributyltin in the eastern mud snail (Ilyanassa obsoleta)

AQUATIC TOXICOLOGY, 78(3), 233–242.

By: R. Sternberg n & G. LeBlanc n

author keywords: tributyltin; imposex; acyl coenzyme A; steroid acyltransferase; testosterone; 17 beta-estradiol; endocrine; snail
MeSH headings : Acyltransferases / antagonists & inhibitors; Acyltransferases / drug effects; Acyltransferases / pharmacokinetics; Animals; Esterification / drug effects; Estradiol / metabolism; Female; Kinetics; Microsomes / enzymology; Palmitoyl Coenzyme A / metabolism; Snails / drug effects; Snails / enzymology; Testosterone / metabolism; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
TL;DR: The results of this study supply the much-needed mechanistic support for the hypothesis that TBT elevates free testosterone in neogastropods by inhibiting their major regulatory process for maintaining free testosterone homeostasis-the fatty acid esterification of testosterone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

A comparative study on androgen metabolism in three invertebrate species

General and Comparative Endocrinology, 143(3), 211–221.

By: G. Janer, G. LeBlanc & C. Porte

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2005 journal article

A comparative study on androgen metabolism in three invertebrate species

General and Comparative Endocrinology, 143(3), 211–221.

By: G. Janer*, G. LeBlanc n & C. Porte*

author keywords: testosterone; androstenedione; metabolism; mollusc; Crustacean; echinoderm
MeSH headings : Amphipoda / physiology; Androstenedione / metabolism; Animals; Biotransformation; Echinodermata / physiology; Female; Male; Sex Characteristics; Snails / physiology; Testosterone / metabolism
TL;DR: Results demonstrate the ubiquity of some androgen biotransformation processes in invertebrates and reveals interphyla differences in androgen metabolic pathways, and different sensitivity of these pathways to some xenobiotics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2005 journal article

An integrated addition and interaction model for assessing toxicity of chemical mixtures

TOXICOLOGICAL SCIENCES, 87(2), 520–528.

By: C. Rider n & G. LeBlanc n

author keywords: synergy; cumulative toxicity; predictive model; toxicodynamic; hazard assessment; risk assessment
MeSH headings : Acetylcholinesterase / metabolism; Algorithms; Animals; Cholinesterase Inhibitors / toxicity; Daphnia / physiology; Dose-Response Relationship, Drug; Drug Interactions; Environmental Pollutants / toxicity; Malathion / toxicity; Models, Biological; Models, Statistical; Parathion / toxicity; Pesticide Synergists / toxicity; Piperonyl Butoxide / toxicity; Toxicity Tests / methods
TL;DR: A mathematical model that combines concepts of concentration addition, response addition, and toxicokinetic chemical interaction to assess toxicity of chemical mixtures is developed and holds promise as a means for assessing hazard of complex chemical mixture. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Androgen metabolism in invertebrates and its modulation by xenoandrogens - A comparative study

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY, Vol. 1040, pp. 354–356.

By: G. Janer*, G. LeBlanc n & C. Porte*

author keywords: androgen; steroid metabolism; organotin; fenarimol; invertebrates
MeSH headings : Androgens / metabolism; Animals; Crustacea / metabolism; Echinodermata / metabolism; Mollusca / metabolism; Species Specificity; Xenobiotics / metabolism
TL;DR: The work evidenced different sensitivity of those pathways to androgenic compounds, together with interphyla differences in androgen metabolism, as well as different sensitivity and tissue‐specific distribution of those enzymatic activities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Covert signal disruption: Anti-ecdysteroidal activity of bisphenol a involves cross talk between signaling pathways

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 24(1), 146–152.

By: X. Mu n, C. Rider n, G. Hwang n, H. Hoy n & G. LeBlanc n

author keywords: crustacean; pollutant; reproduction; steroid; terpenoid
MeSH headings : Animals; Benzhydryl Compounds; Daphnia / drug effects; Daphnia / embryology; Daphnia / growth & development; Dose-Response Relationship, Drug; Ecdysteroids / antagonists & inhibitors; Ecdysterone / pharmacology; Juvenile Hormones / physiology; Molting / drug effects; Phenols / antagonists & inhibitors; Phenols / toxicity; Sex Differentiation / drug effects; Signal Transduction / drug effects; Time; Water Pollutants, Chemical / toxicity
TL;DR: It is demonstrated that bisphenol A is chronically toxic to daphnids, probably through its ability to interfere with ecdysteroid/juvenoid regulated processes, however, effects are elicited at levels that are not likely to pose environmental concern. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Joint action of polycyclic aromatic hydrocarbons: Predictive modeling of sublethal toxicity

AQUATIC TOXICOLOGY, 75(3), 253–262.

By: A. Olmstead n & G. LeBlanc n

author keywords: hazard assessment; risk assessment; response addition; synergy; mixture toxicology
MeSH headings : Algorithms; Animals; Daphnia / drug effects; Daphnia / growth & development; Dose-Response Relationship, Drug; Models, Biological; Polycyclic Aromatic Hydrocarbons / toxicity; Toxicology / methods
TL;DR: Results indicate that PAHs elicit toxicity to daphnids by multiple mechanisms and demonstrate an appropriate modeling approach to assess the toxicity of these PAH mixtures. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Stress signaling: coregulation of hemoglobin and male sex determination through a terpenoid signaling pathway in a crustacean

JOURNAL OF EXPERIMENTAL BIOLOGY, 208(1), 15–23.

By: C. Rider n, T. Gorr*, A. Olmstead n, B. Wasilak n & G. Leblanc n

author keywords: Cladocera; juvenoid; endocrine disruption; evolution; nuclear receptor; Daphnia magna
MeSH headings : Analysis of Variance; Animals; Base Sequence; DNA Primers; Daphnia / physiology; Electrophoresis; Fatty Acids, Unsaturated / pharmacology; Hemoglobins / genetics; Hemoglobins / metabolism; Male; Molecular Sequence Data; Reproduction / physiology; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sex Differentiation / drug effects; Signal Transduction / physiology; Spectrophotometry; Stress, Physiological / metabolism; Terpenes / metabolism
TL;DR: It is demonstrated that two responses to environmental stress signaling in the crustacean Daphnia magna - hemoglobin accumulation and male offspring production - are co-elevated by the crustACEan terpenoid hormone methyl farnesoate and several synthetic analogs, suggesting that both processes are regulated by the same ter penoid signaling pathway. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Testosterone conjugating activities in invertebrates: are they targets for endocrine disruptors?

AQUATIC TOXICOLOGY, 71(3), 273–282.

By: G. Janer*, R. Sternberg n, G. LeBlanc n & C. Porte*

author keywords: sulfotransferase; Acyl-CoA; testosterone acyltransferase; echinoderm; Crustacea; mollusc
MeSH headings : Acyltransferases / metabolism; Analysis of Variance; Animals; Cytosol / metabolism; Invertebrates / drug effects; Invertebrates / enzymology; Italy; Kinetics; Microsomes / metabolism; Organotin Compounds / toxicity; Palmitoyl Coenzyme A / metabolism; Pyrimidines / toxicity; Seawater; Species Specificity; Sulfotransferases / metabolism; Testosterone / metabolism; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
TL;DR: The results demonstrated the existence of interphyla differences in testosterone conjugation, and revealed that these processes can serve as targets for endocrine disrupting chemicals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Testosterone-fatty acid esterification: A unique target for the endocrine toxicity of tributyltin to gastropods

LeBlanc, G. A., Gooding, M. P., & Sternberg, R. M. (2005, February). INTEGRATIVE AND COMPARATIVE BIOLOGY, Vol. 45, pp. 81–87.

By: G. LeBlanc n, M. Gooding & R. Sternberg

TL;DR: Observations of imposex and free testosterone levels were elevated in field collected snails containing high tin levels, while testosterone-fatty acid ester pools were reduced in these organisms, indicating that tributyltin elevates free testosterone by reducing the retention of testosterone as fatty acid-esters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

The screening of chemicals for juvenoid-related endocrine activity using the water flea Daphnia magna

AQUATIC TOXICOLOGY, 74(3), 193–204.

By: H. Wang n, A. Olmstead n, H. Li n & G. LeBlanc n

author keywords: endocrine disruptors; screening; juvenoids; sex determination
MeSH headings : Animals; Benzhydryl Compounds; Daphnia / drug effects; Daphnia / metabolism; Ecdysteroids / metabolism; Ecdysteroids / pharmacology; Endocrine System / drug effects; Endpoint Determination / methods; Fatty Acids, Unsaturated / pharmacology; Female; Juvenile Hormones / agonists; Juvenile Hormones / antagonists & inhibitors; Juvenile Hormones / metabolism; Male; Methoprene / pharmacology; Pesticides / toxicity; Phenols / toxicity; Phytol / pharmacology; Pyridines / pharmacology; Reproducibility of Results; Sex Differentiation / drug effects; Toxicity Tests / methods; Tretinoin / pharmacology; United States; United States Environmental Protection Agency
TL;DR: Results demonstrate that an in vivo assay with a crustacean species customarily employed in toxicity testing can be used to effectively screen chemicals for juvenoid-modulating activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Toxicity Assessment of Environmentally Relevant Pollutant Mixtures Using a Heuristic Model

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, 1(2), 114–122.

By: A. Olmstead n & G. LeBlanc n

author keywords: Mixture toxicology; Mixture model; Daphnid; Insecticides; Pollutants
MeSH headings : Animals; Daphnia; Endpoint Determination; Environmental Pollutants / toxicity; Forecasting; Models, Theoretical; Sensitivity and Specificity; Xenobiotics / toxicity
TL;DR: Toxicity was not influenced significantly by interactions among the chemicals and a single constituent dominated toxicity, and the median detected environmental concentrations of chemicals constituting this mixture provided no margin of safety. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 chapter

Acute Toxicity

In A Textbook of Modern Toxicology (pp. 213–224).

By: G. Leblanc n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 8, 2019

2004 chapter

Basics of Environmental Toxicology

In A Textbook of Modern Toxicology (pp. 463–478).

By: G. Leblanc n

UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 17, 2019

2004 journal article

Cross communication between signaling pathways: Juvenoid hormones modulate ecdysteroid activity in a crustacean

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY, 301A(10), 793–801.

By: X. Mu n & G. Leblanc n

MeSH headings : Animals; Cell Proliferation / drug effects; Cells, Cultured; DNA Primers; Daphnia / drug effects; Daphnia / embryology; Daphnia / metabolism; Drosophila; Ecdysteroids / metabolism; Ecdysterone / pharmacology; Embryo, Nonmammalian / drug effects; Fatty Acids, Unsaturated / toxicity; Gene Expression Regulation / drug effects; Juvenile Hormones / antagonists & inhibitors; Juvenile Hormones / toxicity; Models, Biological; Phenylcarbamates / toxicity; Pyridines / toxicity; Pyrimidines / metabolism; RNA, Messenger / metabolism; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Sex Determination Processes; Signal Transduction / physiology; Testosterone / metabolism
TL;DR: Results demonstrated that juvenoids elicit anti-ecdysteroidal activity in a crustacean through a unique mechanism of action. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 chapter

Elimination of Toxicants

In A Textbook of Modern Toxicology (pp. 203–211).

By: G. Leblanc n

Sources: Crossref, NC State University Libraries
Added: December 8, 2019

2004 chapter

Endocrine System

In A Textbook of Modern Toxicology (pp. 299–315).

By: G. Leblanc n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 8, 2019

2004 personal communication

Evaluating the toxicity of chemical mixtures

LeBlanc, G. A., & Olmstead, A. W. (2004, September).

By: G. LeBlanc* & A. Olmstead*

MeSH headings : Animals; Data Interpretation, Statistical; Drug Interactions; Endocrine System / drug effects; Estrogens / toxicity; Estrogens, Non-Steroidal / toxicity; Female; Rats; Uterus / drug effects; Uterus / growth & development
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Interactive effects of vinclozolin and testosterone propionate on pregnancy and sexual differentiation of the male and female SD Rat

TOXICOLOGICAL SCIENCES, 78(1), 135–143.

By: C. Wolf*, G. LeBlanc & L. Gray

author keywords: sexual differentiation; endocrine-disrupting compounds; cumulative risk; androgen; antiandrogen
MeSH headings : Abnormalities, Drug-Induced / epidemiology; Abnormalities, Drug-Induced / pathology; Androgen Antagonists / pharmacology; Androgen Antagonists / toxicity; Animals; Animals, Newborn; Birth Weight / drug effects; Body Weight / drug effects; Female; Fetal Viability / drug effects; Fetus / metabolism; Genitalia / drug effects; Genitalia / growth & development; Male; Organ Size / drug effects; Oxazoles / antagonists & inhibitors; Oxazoles / pharmacology; Oxazoles / toxicity; Pregnancy; Pregnancy, Animal / drug effects; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sex Differentiation / drug effects; Sexual Maturation / drug effects; Teratogens / toxicity; Testosterone Propionate / antagonists & inhibitors; Testosterone Propionate / metabolism; Testosterone Propionate / pharmacology; Weight Gain / drug effects
TL;DR: It is observed that the combination of V and TP, two chemicals with opposing endocrine action, antagonized one another during sexual differentiation, especially in the female offspring and induced cumulative effects on maternal and neonatal toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 chapter

Introduction to Biochemical and Molecular Methods in Toxicology

In E. Hodgson (Ed.), A Textbook of Modern Toxicology (pp. 13–22).

By: E. Hodgson n, G. Leblanc n, S. Meyer* & R. Smart n

Ed(s): E. Hodgson n

Sources: Crossref, NC State University Libraries
Added: December 8, 2019

2004 journal article

Non-target toxicology of a new mosquito larvicide, trypsin modulating oostatic factor

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 80(3), 131–142.

By: D. Thompson n, H. Young n, F. Edens n, A. Olmstead n, G. LeBlanc n, E. Hodgson n, R. Roe n

author keywords: trypsin modulating oostatic factor; TMOF; insecticide; mosquito; mouse; rabbit; duck; water flea
TL;DR: It appears from these studies that T MOF can be degraded by vertebrate digestive proteases and technical TMOF is not toxic to the non-target organisms examined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Seasonal variation in the regulation of testosterone levels in the eastern mud snail (Ilyanassa obsoleta)

Invertebrate Biology, 123(3), 237–243.

By: M. Gooding n & G. LeBlanc n

TL;DR: This study provides compelling evidence that free testosterone levels in the mud snail are regulated through fatty acid esterification/de-esterification processes and this regulatory function contributes to seasonal fluctuations in freeosterone levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2004 journal article

Synergistic interaction of endocrine-disrupting chemicals: Model development using an ecdysone receptor antagonist and a hormone synthesis inhibitor

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 23(4), 1085–1091.

By: X. Mu n & G. LeBlanc n

author keywords: endocrine; disruptors; invertebrate; mixtures; synergy
MeSH headings : Algorithms; Animals; Daphnia / growth & development; Daphnia / physiology; Drug Interactions; Ecdysteroids / biosynthesis; Embryonic Development; Endocrine System / drug effects; Environmental Pollutants / toxicity; Fungicides, Industrial / toxicity; Models, Theoretical; Pyrimidines / toxicity; Risk Assessment; Testosterone / pharmacology
TL;DR: The hypothesis that combined exposure to chemicals that inhibit hormone synthesis and that function as hormone receptor antagonists would result in greater‐than‐additive toxicity is tested and it is demonstrated that some endocrine toxicants can synergize, and this synergy can be accurately predicted. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Insecticidal juvenile hormone analogs stimulate the production of male offspring in the crustacean Daphnia magna

ENVIRONMENTAL HEALTH PERSPECTIVES, 111(7), 919–924.

By: A. Olmstead n & G. LeBlanc n

author keywords: crustacea; Daphnia; endocrine disruption; invertebrate; methoprene; methyl farnesoate; mixtures; pyriproxyfen
MeSH headings : Animals; Daphnia / physiology; Female; Juvenile Hormones / chemistry; Juvenile Hormones / pharmacology; Male; Sex Ratio
TL;DR: It is demonstrated that insecticidal JHAs mimic the action of the crustacean juvenoid hormone methyl farnesoate, resulting in the inappropriate production of male offspring. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

The biocide tributyltin reduces the accumulation of testosterone as fatty acid esters in the mud snail (Ilyanassa obsoleta)

ENVIRONMENTAL HEALTH PERSPECTIVES, 111(4), 426–430.

By: M. Gooding n, V. Wilson*, L. Folmar n, D. Marcovich n & G. LeBlanc n

author keywords: acyltransferase; fatty acid esters; Ilyanassa obsoleta; imposex; invertebrate endocrinology; mud snail; testosterone; tributyltin
MeSH headings : Animals; Disorders of Sex Development / chemically induced; Environmental Exposure; Esters; Fatty Acids / metabolism; Female; Male; Snails / physiology; Testosterone / blood; Testosterone / metabolism; Trialkyltin Compounds / adverse effects
TL;DR: Results indicate that TBT elevates free testosterone levels in snails by decreasing the production or retention of testosterone-fatty acid esters, and may be a co-contributor to the testosterone fatty esterification process or a factor in the enhanced hydrolysis of the testosterone- fatty acid pool. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 chapter

The influence of speciation on the toxicity of silver to fathead minnows (Pimephales promelas)

In J. W. Gorsuch, J. R. Kramer, & T. W. LaPoint (Eds.), Silver : environmental transport, fate, effects, and models : papers from Environmental toxicology and chemistry, 1983 to 200 (pp. 313–322). Pensacola, FL: SETAC.

By: G. LeBlanc, J. Mastone, A. Paradice, B. Wilson, H. Lockhart & K. Robillard

Ed(s): J. Gorsuch, J. Kramer & T. LaPoint

Source: NC State University Libraries
Added: March 18, 2021

2002 journal article

Abstracts from the Eleventh International Symposium on Pollutant Responses in Marine Organisms (PRIMO 11) - Endocrine disrupters

Marine Environmental Research, 54(3-5), 741–754.

By: X. Mu, C. Rider & G. Leblanc

Source: NC State University Libraries
Added: August 6, 2018

2002 chapter

Biological Processes

In A. W. Andren & T. W. Bober (Eds.), Silver in the Environment: Transport, Fate and Effects (pp. 65–96). Pensacola, FL: SETAC Press.

By: S. Luoma, C. Hogstrand, R. Bell, G. Bielmyer, F. Galvez, G. LeBlanc, B. Lee, T. Purcell ...

Ed(s): A. Andren & T. Bober

Source: NC State University Libraries
Added: March 26, 2021

2002 journal article

Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 129(2), 127–133.

By: X. Mu n & G. LeBlanc n

MeSH headings : Animals; Crustacea / drug effects; Crustacea / embryology; Crustacea / growth & development; Ecdysteroids / antagonists & inhibitors; Ecdysterone / pharmacology; Embryo, Nonmammalian / drug effects; Gonadal Steroid Hormones / poisoning; Molting / drug effects; Testosterone / poisoning
TL;DR: It is demonstrated that ecdysteroids regulate critical processes in daphnid embryo development and testosterone elicits embryo toxicity todaphnids by interfering with Ecdysteroid activity, and that ecdysone receptor antagonism could be one mechanism by which testosterone elicited these effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Effects of prenatal testosterone propionate on the sexual development of male and female rats: A dose-response study

TOXICOLOGICAL SCIENCES, 65(1), 71–86.

By: C. Wolf*, A. Hotchkiss, J. Ostby, G. LeBlanc & L. Gray

author keywords: testosterone propionate; androgens; masculinization; prenatal exposure; sexual differentiation; anogenital distance; agenesis of the lower vagina; Sprague-Dawley rats
MeSH headings : Abnormalities, Drug-Induced / etiology; Anal Canal / abnormalities; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Genitalia, Female / abnormalities; Genitalia, Male / abnormalities; Gonadal Steroid Hormones / administration & dosage; Gonadal Steroid Hormones / physiology; Gonadal Steroid Hormones / toxicity; Male; Maternal Exposure / adverse effects; Nipples / abnormalities; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Testosterone / administration & dosage; Testosterone / physiology; Testosterone / toxicity; Toxicity Tests; Vagina / abnormalities
TL;DR: Gestation administration of 0.5 and 1 mg TP masculinizes female offspring without greatly affecting pup viability or pregnancy of the dam, and this study provides a useful model for in utero testing of environmental androgens for their potential to induce developmental abnormalities. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Environmental antiecdysteroids alter embryo development in the crustacean Daphnia magna

JOURNAL OF EXPERIMENTAL ZOOLOGY, 292(3), 287–292.

By: X. Mu n & G. LeBlanc n

MeSH headings : Animals; Congenital Abnormalities / physiopathology; Congenital Abnormalities / veterinary; Daphnia / embryology; Ecdysone / antagonists & inhibitors; Female; Fertility; Fungicides, Industrial / pharmacology; Molting / physiology; Pyrimidines / pharmacology
TL;DR: It is demonstrated that ecdysteroids are critical to normal crustacean embryo development and environmental antiecdysteroidal activity may provide a means by which environmental chemicals impact crustaceans species while not affecting vertebrates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Juvenoid hormone methyl farnesoate is a sex determinant in the crustacean Daphnia magna

JOURNAL OF EXPERIMENTAL ZOOLOGY, 293(7), 736–739.

By: A. Olmstead n & G. Leblanc n

MeSH headings : Animals; Daphnia / drug effects; Daphnia / embryology; Daphnia / growth & development; Daphnia / physiology; Environment; Fatty Acids, Unsaturated / administration & dosage; Fatty Acids, Unsaturated / pharmacology; Female; Juvenile Hormones / administration & dosage; Juvenile Hormones / pharmacology; Male; Reproduction; Sex Differentiation / drug effects; Time Factors
TL;DR: Results demonstrate that methyl farnesoate is capable of programming daphnid embryos to develop into males and is likely the endocrine factor responsible for initiating the sexual reproductive phase in these organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Alterations in sexually dimorphic biotransformation of testosterone in juvenile American alligators (Alligator mississippiensis) from contaminated lakes

ENVIRONMENTAL HEALTH PERSPECTIVES, 109(12), 1257–1264.

By: M. Gunderson, G. LeBlanc* & L. Guillette

author keywords: alligator; hydroxylase; oxido-reductase; sexual dimorphism; sulfotransferase; testosterone biotransformation; UDP-glucuronosyltransferase
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Biotransformation and disposition of testosterone in the eastern mud snail Ilyanassa obsoleta

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 122(2), 172–180.

By: M. Gooding n & G. LeBlanc n

author keywords: Ilyanassa obsoleta; mud snail; fatty acid conjugates; testosterone; imposex; invertebrate endocrinology; tributyltin
MeSH headings : Acyltransferases / metabolism; Animals; Biotransformation; Chromatography, Thin Layer; Disorders of Sex Development / metabolism; Fatty Acids, Nonesterified / blood; Hydrolysis; Snails / metabolism; Testosterone / pharmacokinetics
TL;DR: Results indicate that AP1, which represents over 70% of the testosterone biotransformation products, is a fatty acid ester of testosterone, which might represent a target of TBT toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 chapter

Conjugation and Elimination of Toxicants

In E. Hodgson & R. C. Smart (Eds.), Introduction to Biochemical Toxicology (3rd ed., pp. 115–136). New York: Wiley.

By: G. LeBlanc

Ed(s): E. Hodgson & R. Smart

Source: NC State University Libraries
Added: March 26, 2021

2001 chapter

Immunochemical Techniques in Toxicology

In E. Hodgson & R. C. Smart (Eds.), Introduction to Biochemical Toxicology (3rd ed., pp. 33–50). New York: Wiley.

By: G. LeBlanc

Ed(s): E. Hodgson & R. Smart

Source: NC State University Libraries
Added: March 26, 2021

2001 journal article

Low Exposure Concentration Effects of Methoprene on Endocrine-Regulated Processes in the Crustacean Daphnia magna

Toxicological Sciences, 62(2), 268–273.

By: A. Olmstead n & G. Le Blanc

author keywords: methoprene; daphnid; crustacea; endocrine disruption; methyl farnesoate
MeSH headings : Animals; Daphnia / drug effects; Daphnia / growth & development; Daphnia / physiology; Dose-Response Relationship, Drug; Endocrine Glands / drug effects; Endocrine Glands / physiology; Fertility; Juvenile Hormones / toxicity; Methoprene / toxicity; Reproduction
TL;DR: It is demonstrated that methoprene elicits significant toxicity to endocrine-related processes in the 5-50 nM concentration range, and molting and reproduction were impacted at significantly lower meethoprene concentrations, with a distinct concentration response and a threshold of < or =0.2 nM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2001 journal article

Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland

BIOLOGY OF REPRODUCTION, 65(5), 1496–1505.

By: O. Putz*, C. Schwartz*, S. Kim*, G. LeBlanc n, R. Cooper* & G. Prins*

author keywords: early development; environment; estradiol; prostate; puberty; steroid hormones; toxicology
MeSH headings : Aging; Animals; Animals, Newborn; Body Weight / drug effects; Cell Differentiation / drug effects; Dose-Response Relationship, Drug; Estradiol / administration & dosage; Estradiol / analogs & derivatives; Estradiol / pharmacology; Male; Organ Size / drug effects; Prostate / drug effects; Prostate / growth & development; Prostate / metabolism; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Androgen / metabolism; Sexual Maturation
TL;DR: In the rat model a sustained effect at low doses of natural estrogens is not present in the prostate glands, and an advancement of puberty as the cause for increased reproductive organ weights on Postnatal Day 35 is suggested. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: II. Effects on male puberty and the reproductive tract

BIOLOGY OF REPRODUCTION, 65(5), 1506–1517.

By: O. Putz*, C. Schwartz*, G. LeBlanc n, R. Cooper* & G. Prins*

author keywords: early development; environment; estradiol; prostate; puberty; steroid hormones; toxicology
MeSH headings : Aging; Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Epididymis / drug effects; Epididymis / growth & development; Estradiol / administration & dosage; Estradiol / analogs & derivatives; Estradiol / pharmacology; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Liver / drug effects; Liver / enzymology; Male; Organ Size / drug effects; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Sexual Maturation / drug effects; Steroid Hydroxylases / metabolism; Testis / drug effects; Testis / growth & development; Testosterone / blood
TL;DR: Results showed an inverted U-shaped dose-response profile for testis and epididymis weights in 35-day-old SD rats, with increased organ sizes at the low-dose end of the treatment, which suggests an advancement of puberty as the cause for increased reproductive organ weights. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Temporal and quantitative changes in sexual reproductive cycling of the cladoceran Daphnia magna by a juvenile hormone analog

JOURNAL OF EXPERIMENTAL ZOOLOGY, 290(2), 148–155.

By: A. Olmstead n & G. LeBlanc n

MeSH headings : Animals; Daphnia / physiology; Female; Juvenile Hormones / physiology; Male; Methoprene / pharmacology; Parthenogenesis; Reproduction
TL;DR: It is demonstrated that methoprene uncouples the coordinate production of males and resting eggs during the sexual reproductive period of D. magna. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

The fungicide propiconazole interferes with embryonic development of the crustacean Daphnia magna

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 20(3), 502–509.

By: K. Kast-Hutcheson, C. Rider & G. LeBlanc*

author keywords: development; embryos; crustaceans; daphnids; propiconazole
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Changes in the metabolic elimination profile of testosterone following exposure of the crustacean Daphnia magna to tributyltin

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 45(3), 296–303.

By: G. LeBlanc n & J. McLachlan n

MeSH headings : Androstane-3,17-diol / analogs & derivatives; Androstane-3,17-diol / analysis; Androstane-3,17-diol / metabolism; Androstenedione / analysis; Androstenedione / metabolism; Animals; Daphnia / drug effects; Daphnia / metabolism; Dihydrotestosterone / analysis; Dihydrotestosterone / metabolism; Dose-Response Relationship, Drug; Female; Glucose / metabolism; Hydroxytestosterones / analysis; Hydroxytestosterones / metabolism; Testosterone / metabolism; Trialkyltin Compounds / toxicity
TL;DR: It is demonstrated that tributyltin causes alterations in testosterone metabolism in daphnids that would result in an increase in the production of oxido-reduced derivatives, which are preferentially retained in the tissues of daphNids and are variously androgenic in vertebrates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Characterization of the period of sensitivity of fetal male sexual development to vinclozolin

TOXICOLOGICAL SCIENCES, 55(1), 152–161.

By: C. Wolf*, G. LeBlanc, J. Ostby & L. Gray

author keywords: vinclozolin; antiandrogen; androgen receptor; male reproductive development; critical period; levator ani; hypospadias; anogenital distance
MeSH headings : Androgen Antagonists / toxicity; Animals; Embryonic and Fetal Development / drug effects; Female; Fertility / drug effects; Fungicides, Industrial / toxicity; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / embryology; Male; Organ Size / drug effects; Oxazoles / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Long-Evans; Sexual Maturation / drug effects; Testis / abnormalities; Weight Gain / drug effects
TL;DR: The data indicate that the reproductive system of the fetal male rat is most sensitive to antiandrogenic effects of vinclozolin, although effects are more severe and 100 % of male offspring are affected with administration of v inclozol from GD 14 through GD 19. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Effects of endocrine-active chemicals on the development of sex characteristics of Daphnia magna

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 19(8), 2107–2113.

By: A. Olmstead* & G. LeBlanc*

author keywords: endocrine disruption; daphnid; sexual differentiation; invertebrate
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to the crustacean Daphnia magna

ENVIRONMENTAL HEALTH PERSPECTIVES, 108(12), 1133–1138.

By: G. LeBlanc*, X. Mu* & C. Rider

author keywords: androgens; crustacean; Daphnia magna; development; embryo; invertebrate; 4-nonylphenol; steroids; testosterone; toxicity
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Fathead minnow vitellogenin: Complementary DNA sequence and messenger RNA and protein expression after 17 beta-estradiol treatment

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 19(4), 972–981.

By: J. Korte, M. Kahl, K. Jensen, M. Pasha, L. Parks*, G. LeBlanc*, G. Ankley

author keywords: vitellogenin; Pimephales promelas; 17 beta-estradiol; mRNA; cDNA
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Organochlorine bioaccumulation and risk for whales in a northwest Atlantic food web

Marine Environmental Research, 50(1-5), 440–441.

By: A. Weisbrod n, D. Shea n, G. Leblanc n, M. Moore* & J. Stegeman*

TL;DR: Dolphin and pilot whale organs contained ample concentrations of specific compounds, notably 4,4′-DDE, that have been shown to alter endocrine function, which contributed to the bioaccumulation patterns observed in dolphins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2000 journal article

Petroleum pollution

Reviews in Toxicology, 3, 77–112.

By: V. Wilson & G. LeBlanc

Source: NC State University Libraries
Added: March 26, 2021

2000 chapter

Steroid hormone-regulated processes in invertebrates and their susceptibility to environmental endocrine disruption

In L. Guillette Jr. & D. A. Crain (Eds.), Environmental Endocrine Disrupters: An Evolutionary Perspective (pp. 126–154).

By: G. Le Blanc

Ed(s): L. Guillette & D. Crain

Sources: Crossref, NC State University Libraries
Added: January 28, 2020

2000 journal article

The contribution of hepatic inactivation of testosterone to the lowering of serum testosterone levels by ketoconazole

Toxicological Sciences, 54(1), 128–137.

By: V. Wilson & G. LeBlanc

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Alteration in sexually dimorphic testosterone biotransformation profiles as a biomarker of chemically induced androgen disruption in mice

ENVIRONMENTAL HEALTH PERSPECTIVES, 107(5), 377–384.

By: V. Wilson, J. McLachlan, J. Falls* & G. LeBlanc*

author keywords: androgen disruption; biomarker; biotransformation; sexually dimorphic metabolism; testosterone
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Fathead minnow (Pimephales promelas) vitellogenin: purification, characterization and quantitative immunoassay for the detection of estrogenic compounds

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 123(2), 113–125.

By: L. Parks n, A. Cheek*, N. Denslow*, S. Heppell n, J. McLachlan*, G. LeBlanc n, C. Sullivan n

author keywords: enzyme-linked immunosorbant assay (ELISA); fathead minnow; vitellogenin; estrogenic compounds; 17 beta-estradiol; toxicology; reproduction; ovary
MeSH headings : Amino Acid Sequence; Animals; Blotting, Western; Chromatography, Ion Exchange; Cyprinidae; Environmental Monitoring; Enzyme-Linked Immunosorbent Assay / methods; Estrogens / analysis; Male; Molecular Sequence Data; Reproducibility of Results; Vitellogenins / biosynthesis; Vitellogenins / chemistry; Vitellogenins / isolation & purification
TL;DR: The VTG ELISA could be useful for the detection of estrogenic properties associated with certain compounds and could be easily incorporated into standard laboratory toxicity assays using this species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Imposex in three marine gastropod species in Chile and potential impact on muriciculture

MARINE POLLUTION BULLETIN, 38(12), 1227–1231.

By: M. Gooding n, C. Gallardo* & G. Leblanc n

author keywords: imposex; gastropod; tributyltin; Chile; Chorus giganteus; Nucella
TL;DR: Since sex of individuals in muriciculture is determined by the presence or absence of a penis, imposex may lead to erroneous classification of males and females and have a negative impact on sustainable cultivation and harvest of gastropods in Chile. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Molt-independent growth inhibition of Daphnia magna by a vertebrate antiandrogen

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 18(7), 1450–1455.

By: G. LeBlanc* & J. McLachlan

author keywords: endocrine disruption; invertebrate; daphnid; antiandrogen; growth
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 chapter

Screening approaches for the evaluation of endocrine disruption in invertebrates

In D. Henshel, M. Harrass, & M. Black (Eds.), Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for Endocrine Disruption and Environmental Assessment (Vol. 8, pp. 3–23).

By: G. LeBlanc n

Ed(s): D. Henshel, M. Harrass & M. Black

author keywords: endocrine disruption; invertebrates; daphnids; screening tests
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 26, 2021

1999 chapter

The endocrinology of invertebrates

In M. Crane, P. L. deFur, C. Ingersoll, & L. Tattersfield (Eds.), Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment (pp. 23–106). Pensacola, FL: SETAC Press.

By: G. LeBlanc, P. Cambell, P. den Besten, R. Brown, E. Chang, J. Coats, P. deFur, T. Dhaldialla ...

Ed(s): M. Crane, P. deFur, C. Ingersoll & L. Tattersfield

Source: NC State University Libraries
Added: April 10, 2021

1999 chapter

Workshop on Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment (EDIETA): Executive Summary

In M. Crane, P. L. DeFur, C. Ingersoll, & L. Tattersfield (Eds.), Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment. Pensacola, FL: SETAC Press.

By: P. DeFur, M. Crane, L. Tattersfield, C. Ingersoll, R. Stahl, P. Matthiessen, G. LeBlanc

Ed(s): M. Crane, P. DeFur, C. Ingersoll & L. Tattersfield

Event: Workshop on Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment at Noordwijkerhout, the Netherlands on December 12-15, 1998

Source: NC State University Libraries
Added: April 8, 2021

1998 journal article

Alteration of [C-14]-testosterone metabolism after chronic exposure of Daphnia magna to tributyltin

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 34(1), 21–25.

By: E. Oberdorster*, D. Rittschof* & G. LeBlanc n

MeSH headings : Animals; Carbon Radioisotopes; Daphnia / drug effects; Daphnia / growth & development; Daphnia / metabolism; Female; Testosterone / metabolism; Trialkyltin Compounds / pharmacology
TL;DR: It is indicated that Alterations of steroid metabolism by xenobiotics can be used as a more sensitive indicator of sublethal exposure in daphnids than reproductive endpoints, and testosterone metabolism is enhanced at concentrations approaching those that are lethal to organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

Altered metabolic elimination of testosterone and associated toxicity following exposure of Daphnia magna to nonylphenol polyethoxylate

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 39(2), 104–111.

By: W. Baldwin n, S. Graham n, D. Shea n & G. LeBlanc n

Contributors: W. Baldwin n, S. Graham n, D. Shea n & G. LeBlanc n

MeSH headings : Animals; Culture Media; Daphnia / drug effects; Daphnia / physiology; Detergents / toxicity; Ethylene Glycols / toxicity; Female; Glucose / metabolism; Phenols / metabolism; Sulfates / metabolism; Testosterone / metabolism
TL;DR: Results from the present study provide no indication that concentrations of nonylphenol polyethoxylates typically measured in the environment pose a risk of chronic toxicity to invertebrates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

1998 chapter

Bioaccumulation

In P. Wexler (Ed.), Encyclopedia of Toxicology (Vol. 1, p. 148). New York: Academic Press Inc.

By: J. Hamelink & G. Le Blanc

Ed(s): P. Wexler

Source: NC State University Libraries
Added: April 10, 2021

1998 journal article

Endosulfan elevates testosterone biotransformation and clearance in CD-1 mice

TOXICOLOGY AND APPLIED PHARMACOLOGY, 148(1), 158–168.

By: V. Wilson n & G. LeBlanc n

MeSH headings : Animals; Biotransformation; Body Weight / drug effects; Cytosol / drug effects; Cytosol / metabolism; Dose-Response Relationship, Drug; Endosulfan / toxicity; Estradiol / blood; Female; Hydrocarbons, Chlorinated; Insecticides / toxicity; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Male; Mice; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Organ Size / drug effects; Testosterone / pharmacokinetics
TL;DR: Results indicate that increases in testosterone biotransformation from endosulfan exposure can result in increases in the elimination of the steroid, however, homeostatic processes apparently compensate for the effect and minimize any consequences on serum hormone levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

Heat resistance of Alicyclobacillus acidoterrestris spores as affected by various pH values and organic acids

JOURNAL OF FOOD PROTECTION, 61(1), 41–46.

By: A. Pontius n, J. Rushing n & P. Foegeding n

MeSH headings : Bacillaceae / isolation & purification; Bacillaceae / physiology; Beverages / microbiology; Carboxylic Acids / pharmacology; Food Contamination / prevention & control; Food Microbiology; Fruit / microbiology; Hot Temperature; Hydrogen-Ion Concentration; Spores, Bacterial / growth & development
TL;DR: The models generated from this research can be used to determine adequate thermal processes, accounting for the acid type, pH, and temperature, to destroy A. acidoterrestris spores in beverages, since this organism is able to survive the typical hot-fill and hold process currently used to process fruit juice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

Involvement of multiple biotransformation processes in the metabolic elimination of testosterone by juvenile and adult fathead minnows (Pimephales promelas)

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 112(1), 69–79.

By: L. Parks n & G. LeBlanc n

MeSH headings : Aging; Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cyprinidae / metabolism; Female; Gas Chromatography-Mass Spectrometry; Hydroxylation; Male; Metabolic Clearance Rate; Oxidation-Reduction; Sex Characteristics; Testosterone / metabolism
TL;DR: It is demonstrated that fathead minnows extensively metabolize testosterone leading to its elimination and provide the foundation upon which the effects of xenobiotics on testosterone metabolism can be assessed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 review

Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife

[Review of ]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 17(1), 68–87.

By: G. Ankley*, E. Mihaich, R. Stahl, D. Tillitt, T. Colborn, S. McMaster, R. Miller, J. Bantle ...

author keywords: estrogen; androgen; endocrine disruption; wildlife; screening
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

The state of the debate

Forum for Applied Research and Public Policy, 13(3), 6–10.

By: G. Le Blanc

Source: NC State University Libraries
Added: April 8, 2021

1998 journal article

Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype

JOURNAL OF NATURAL PRODUCTS, 61(1), 112–115.

By: G. Ma*, T. Wang, L. Yin, Y. Pan, Y. Guo*, G. LeBlanc n, M. Reinecke, W. Watson, M. Krawiec

MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; Animals; Antineoplastic Agents, Phytogenic / isolation & purification; Antineoplastic Agents, Phytogenic / pharmacology; Doxorubicin / pharmacology; Genes, MDR / drug effects; Humans; Magnetic Resonance Spectroscopy; Mice; Phenanthrenes / isolation & purification; Phenanthrenes / pharmacology; Phenotype; Plant Stems / chemistry; Structure-Activity Relationship; Tumor Cells, Cultured; X-Ray Diffraction
TL;DR: Two new pimarane diterpenoids, lonchophylloids A and B, were isolated from the stems of Ephemerantha lon chophylla and were capable of sensitizing cells that expressed the multidrug resistance phenotype to the toxicity of the anticancer drug doxorubicin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1997 journal article

At the cutting edge - Pesticides: Multiple mechanisms of demasculinization

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 126(1), 1–5.

By: G. LeBlanc n, L. Bain n & V. Wilson n

author keywords: pesticides; demasculinization; feminization; endocrine; steroid hormones; receptors; biotransformation; synergism
MeSH headings : Androgen Antagonists / pharmacology; Androgen Receptor Antagonists; Animals; Female; Feminization / chemically induced; Genitalia, Male / drug effects; Genitalia, Male / growth & development; Humans; Male; Pesticides / pharmacology; Receptors, Estrogen / drug effects
TL;DR: Given the ubiquity of pesticides in the environment and the multiple mechanisms whereby they can elicit demasculinizing effects, synergy between such compounds may produce clinical endocrine dysfunction at current human exposure levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1997 chapter

Basics of Environmental Toxicology

In E. Hodgson & P. E. Levi (Eds.), A Textbook of Modern Toxicology (2nd ed., pp. 389–406). Stamford, CT: Appleton & Lange.

By: G. Le Blanc

Ed(s): E. Hodgson & P. Levi

Source: NC State University Libraries
Added: October 24, 2021

1997 chapter

Chemical contamination affects wildlife

In C. P. Cozic (Ed.), Garbage & Waste (pp. 92–95). San Diego, California: Greenhaven Press, Inc.

By: G. Le Blanc

Ed(s): C. Cozic

Source: NC State University Libraries
Added: October 24, 2021

1997 journal article

Chronic toxicity of environmental contaminants: Sentinels and biomarkers

Environmental Health Perspectives, 105(Suppl. 1), 65–80.

By: G. LeBlanc n & L. Bain n

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1997 chapter

Elimination of Toxicants

In E. Hodgson & P. E. Levi (Eds.), A Textbook of Modern Toxicology (2nd ed., pp. 107–118). Stamford, CT: Appleton & Lange.

By: P. Levi, E. Hodgson & G. Le Blanc

Ed(s): E. Hodgson & P. Levi

Source: NC State University Libraries
Added: October 24, 2021

1997 chapter

Invertebrates as sentinels of xenobiotic-induced endocrine disruption

In P. Guttry (Ed.), Endocrine Disruptors: Advances in Measuring and Analyzing Their Effects (pp. 1–24). Southborough, MA: International Business Communications.

By: G. Le Blanc

Ed(s): P. Guttry

Source: NC State University Libraries
Added: October 24, 2021

1997 journal article

Metabolic androgenization of female Daphnia magna by the xenoestrogen 4-nonylphenol

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 16(9), 1905–1911.

By: W. Baldwin*, S. Graham*, D. Shea* & G. LeBlanc*

Contributors: W. Baldwin*, S. Graham*, D. Shea* & G. Leblanc*

author keywords: 4-nonylphenol; androgenization; steroid metabolism; Daphnia magna
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

1997 journal article

Reversal of multidrug resistance by derivatives of acrivastine: a study of structure activity relationships of P glycoprotein inhibitors in vitro and in vivo

Oncology Reports, 4(6), 1353–1360.

By: J. Christensen, L. Parks, R. McNutt & G. Leblanc

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein

ENVIRONMENTAL HEALTH PERSPECTIVES, 105(8), 812–818.

By: L. Bain*, J. McLachlan & G. LeBlanc*

author keywords: multidrug resistance; multixenobiotic resistance; pesticides; P-glycoprotein; structure-activity relationships
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1996 journal article

Expression and induction of an immunochemically related class of glutathione S-transferases in Daphnia magna

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 113(2), 261–267.

By: W. Baldwin n & G. Leblanc n

author keywords: antibodies; 1-chloro-2,4-dinitrobenzene; Daphnia magna; glutathione S-transferases; phenobarbital
MeSH headings : Animals; Chromatography, Affinity; Cytosol / enzymology; Daphnia / enzymology; Enzyme Induction / drug effects; Glutathione Transferase / biosynthesis; Glutathione Transferase / immunology; Glutathione Transferase / isolation & purification; Immunoblotting; Isoelectric Focusing; Isoenzymes / biosynthesis; Isoenzymes / immunology; Isoenzymes / isolation & purification; Kinetics; Phenobarbital / pharmacology
TL;DR: It is demonstrated that multiple immunochemically related proteins of the same molecular weight but varying isoelectric points are responsible for most of the GST catalytic activity with the substrate 1-chloro-2,4-dinitrobenzene. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

1996 journal article

Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein

Toxicology and Applied Pharmacology, 141(1), 288–298.

By: L. Bain n & G. LeBlanc n

TL;DR: It is demonstrated that many pesticides are capable of binding to P-gp; however, binding does not infer transport. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

1996 journal article

Mobilization of Pentachlorophenol by GlutathioneS-Transferase μ Increases Cellular Toxicity

Pesticide Biochemistry and Physiology, 54(1), 65–72.

By: L. Bain n & G. LeBlanc n

TL;DR: It is suggested that GST μ may increase the cellular toxicity of PCP by mobilizing this lipophilic compound within the cell by acting to make PCP more bioavailable to elicit toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

1996 journal article

Overexpression of ap-glycoprotein in hepatocellular carcinomas from woodchuck hepatitis virus-infected woodchucks (Marmota monax)

Hepatology, 23(4), 662–668.

By: S. Dunn n, C. Hughes n, G. LeBlanc n & J. Cullen n

MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / analysis; ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Animals; Base Sequence; Carcinoma, Hepatocellular / drug therapy; Carcinoma, Hepatocellular / etiology; Carcinoma, Hepatocellular / metabolism; Hepatitis B / complications; Hepatitis B Virus, Woodchuck; Liver Neoplasms / drug therapy; Liver Neoplasms / etiology; Liver Neoplasms / metabolism; Marmota; Molecular Sequence Data; RNA, Messenger / analysis
TL;DR: The first example of the induction of a pgp in a naturally hepadnavirus infected rodent system is shown, suggesting the woodchuck can be a useful model for the study of the acquisition of resistance to chemotherapeutic agents in virally induced HCCs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

1996 journal article

Reductions in steroid hormone biotransformation/elimination as a biomarker of pentachlorophenol chronic toxicity

Aquatic Toxicology, 34(4), 291–303.

By: L. Parks n & G. LeBlanc n

author keywords: pentachlorophenol; chronic toxicity; endocrine disrupter; biomarker; Daphnia; steroid hormones; biotransformation; hydroxylase; glucosyl transferase; sulfotransferase
TL;DR: It is demonstrated that PCP alters steroid hormone biotransformation/elimination capacities at concentrations that adversely affect reproduction and effects on steroid hormoneBiOTransformation can be detected following short-term exposure to PCP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

1996 journal article

Reversal of multi-drug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol

Cancer Research, 56(3), 574–581.

By: J. Christensen & G. Le Blanc

Source: NC State University Libraries
Added: April 8, 2021

1995 journal article

Are environmental sentinels signaling?

Environmental Health Perspectives, 103(10), 888–890.

By: G. LeBlanc n

MeSH headings : Animals; Endocrine Glands / drug effects; Environmental Pollutants / toxicity; Humans; Pesticides / toxicity; Reproduction / drug effects
TL;DR: Scientists, regulators, and legislators must mobilize to identify current health threats posed by environmental pollutants, develop testing protocols that will detect such properties of new chemicals, and strengthen legislation designed to protect environmental health. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 28, 2020

1995 journal article

PHYSIOLOGICAL AND BIOCHEMICAL PERTURBATIONS IN DAPHNIA MAGNA FOLLOWING EXPOSURE TO THE MODEL ENVIRONMENTAL ESTROGEN DIETHYLSTILBESTROL

Environmental Toxicology and Chemistry, 14(6), 945.

By: W. Baldwin, D. Milam & G. LeBlanc*

author keywords: DAPHNIA; ESTROGENS; DIETHYLSTILBESTROL; BIOMARKER; BIOTRANSFORMATION
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 28, 2020

1995 journal article

Subtle effects: devastating consequences

SETAC News, 15(3), 30–31.

By: G. Le Blanc

Source: NC State University Libraries
Added: October 24, 2021

1995 journal article

Trophic-Level Differences in the Bioconcentration of Chemicals: Implications in Assessing Environmental Biomagnification

Environmental Science & Technology, 29(1), 154–160.

By: G. LeBlanc*

TL;DR: Trophic-level differences in bioconcentration are due largely to increased lipid content and decreased chemical elimination efficiency of organisms occupying increasing trophic levels, which can be misconstrued as biomagnification. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

1994 journal article

Assessing deleterious ecosystem-level effects of environmental pollutants as a means of avoiding evolutionary consequences.

Environmental Health Perspectives, 102(3), 266–267.

By: G. LeBlanc n

author keywords: ECOTOXICOLOGY; EVOLUTION; MESOCOSMS; MICROCOSMS; MODEL ECOSYSTEMS; POLLUTION
MeSH headings : Animals; Biological Evolution; Ecosystem; Environmental Pollutants / pharmacology; Humans
TL;DR: Emphasis needs to be placed on assessing the adverse effects of environmental pollutants on ecosystem structure and function in order to avoid subsequent evolutionary consequences. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 28, 2020

1994 journal article

Effect of the plant compound indole-3-carbinol on hepatic cholesterol homoeostasis

Food and Chemical Toxicology, 32(7), 633–639.

By: G. Le Blanc n, J. Stuart n, S. Dunn n & W. Baldwin n

MeSH headings : Animals; Cholesterol / blood; Cholesterol / chemistry; Cholesterol 7-alpha-Hydroxylase / metabolism; Homeostasis / drug effects; Indoles / pharmacology; Liver / chemistry; Liver / drug effects; Male; Mice; Microsomes, Liver / chemistry; Microsomes, Liver / drug effects; Sterol Esterase / metabolism; Sterol O-Acyltransferase / metabolism
TL;DR: I3C lowers serum cholesterol levels at concentrations that have no discernible effect on hepatic cholesterol homoeostasis, and at higher doses of I3C, hepatic microsomal cholesterol levels are significantly lowered and ACAT activity is significantly elevated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1994 journal article

Hepatic vectorial transport of xenobiotics

Chemico-Biological Interactions, 90(2), 101–120.

By: G. LeBlanc n

author keywords: TRANSPORT; TRANSFER; XENOBIOTICS; INFLUX; EFFLUX; LIVER
MeSH headings : 3-Hydroxysteroid Dehydrogenases / metabolism; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); ATP Binding Cassette Transporter, Subfamily B, Member 1; Animals; Biological Transport, Active; Carrier Proteins / metabolism; Cell Membrane / metabolism; Cell Nucleus / metabolism; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Glutathione Transferase / metabolism; Humans; Liver / drug effects; Liver / metabolism; Membrane Glycoproteins / metabolism; Neoplasm Proteins; Tumor Suppressor Proteins; Xenobiotics / pharmacokinetics; Xenobiotics / toxicity
TL;DR: The vectorial transport of xenobiotics across the hepatocyte is mediated by various transport and transfer proteins that differ in ligand specificity and function, which will significantly advance the understanding of processes involved in xenobiotic toxicity and acquired resistance to chemical toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 28, 2020

1994 journal article

Hypocholesterolemic properties of plant indoles

Biochemical Pharmacology, 47(2), 359–364.

By: S. Dunn n & G. LeBlanc n

author keywords: INDOLE-3-CARBINOL; CHOLESTEROL; ACYL-COA-CHOLESTEROL ACYLTRANSFERASE
MeSH headings : Animals; Anticholesteremic Agents / pharmacology; Cholesterol, LDL / blood; Cholesterol, VLDL / blood; Down-Regulation; Glucosinolates / pharmacology; Indoles / chemical synthesis; Indoles / isolation & purification; Indoles / pharmacology; Mice; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Plants / chemistry; Sterol O-Acyltransferase / antagonists & inhibitors; Sterol O-Acyltransferase / metabolism
TL;DR: I3C lowered serum LDL/VLDL cholesterol levels in mice, and this effect was likely mediated by the inhibition of ACAT by some of the acid condensation products of I3C, which provide a possible mechanism by which I 3C-rich vegetables lower serum cholesterol levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 28, 2020

1994 journal article

IDENTIFICATION OF MULTIPLE STEROID HYDROXYLASES IN DAPHNIA MAGNA AND THEIR MODULATION BY XENOBIOTICS

Environmental Toxicology and Chemistry, 13(7), 1013.

By: W. Baldwin & G. LeBlanc*

author keywords: DAPHNIA; BIOMARKER; P450; TESTOSTERONE; METABOLISM
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1994 journal article

In vivo biotransformation of testosterone by phase I and II detoxication enzymes and their modulation by 20-hydroxyecdysone in Daphnia magna

Aquatic Toxicology, 29(1-2), 103–117.

By: W. Baldwin n & G. LeBlanc n

author keywords: TESTOSTERONE; DAPHNIA-MAGNA; OXIDATION; CONJUGATION; 20-HYDROXYECDYSONE
TL;DR: It is demonstrated that daphnids can convert polycyclic compounds to multiple polar and nonpolar metabolites resulting from both phase I and phase II biotransformations, and that some phase II activities are under the regulatory control of 20-hydroxyecdysone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1993 journal article

Elevation of serum cholesterol levels in mice by the antioxidant butylated hydroxyanisole

Biochemical Pharmacology, 45(2), 513–515.

By: G. Le Blanc n & J. Gillette n

MeSH headings : Animals; Antioxidants / pharmacology; Body Weight; Butylated Hydroxyanisole / pharmacology; Cholesterol / blood; Cholesterol, Dietary / administration & dosage; Male; Mice; Microsomes, Liver / metabolism; Probucol / pharmacology; Up-Regulation
TL;DR: It is demonstrated that the common food additive BHA elevates serum cholesterol levels by a mechanism that apparently involves the decreased uptake of cholesterol by the liver. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 28, 2021

1992 journal article

Hormonal perturbations in patients with testicular cancer treated with cisplatin

Cancer, 69(9), 2306–2310.

By: G. Leblanc n, P. Kantoff*, S. Ng*, E. Frei* & D. Waxman*

TL;DR: Analysis of serum free testosterone, total testosterone, and androstenedione levels revealed that these hormones were not altered significantly in patients during a 38‐week period of cisplatin‐based treatment and follow‐up, and suggest that cisPlatin contributes to the perturbation of steroid and peptide hormone levels in patients with testicular cancer and perhaps in others undergoing cisplasin‐based chemotherapy. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1992 journal article

Photoaffinity labelling of steroid-hormone-binding glutathione S-transferases with [3H]methyltrienolone. Inhibition of steroid-binding activity by the anticarcinogen indole-3-carbinol

Biochemical Journal, 288(2), 361–367.

By: D. Danger n, W. Baldwin n & G. LeBlanc n

MeSH headings : Affinity Labels; Animals; Butylated Hydroxyanisole / pharmacology; Cytosol / enzymology; Enzyme Induction; Glutathione Transferase / chemistry; Indoles / chemistry; Liver / enzymology; Male; Metribolone / chemistry; Mice; Phenobarbital / pharmacology; Photochemistry; Precipitin Tests; Protein Binding; Steroids / metabolism
TL;DR: The effects of the anticarcinogenic plant compound indole-3-carbinol (I3C) on GST-mediated steroid hormone-binding using the photoaffinity labelling techniques suggest that I3C may inhibit GST- mediated steroid-binding activity which could contribute to the anticARCinogenic activity of this compound. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 28, 2021

1992 journal article

Platinum Anticancer Drugs Modulate P-450 mRNA Levels and Differentially Alter Hepatic Drug and Steroid Hormone Metabolism in Male and Female Rats

Cancer Research, 52(3), 540–547.

By: G. Le Blanc, S. Sundseth, G. Weber & D. Waxman

Source: NC State University Libraries
Added: October 28, 2021

1992 journal article

The anti-carcinogenic plant compound indole-3-carbinol differentially modulates P450-mediated steroid hydroxylase activities in mice

Chemico-Biological Interactions, 83(2), 155–169.

By: W. Baldwin n & G. Leblanc n

author keywords: INDOLE-3-CARBINOL; P450; ANTICARCINOGENESIS; STEROID HYDROXYLASE
MeSH headings : Animals; Anticarcinogenic Agents / pharmacology; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System / metabolism; Enzyme Induction / drug effects; Indoles / pharmacology; Liver / enzymology; Male; Mice; Mice, Inbred Strains; Oxidoreductases / metabolism; Steroid Hydroxylases / metabolism
TL;DR: It is shown that I3C can elicit both inductive and suppressive effects on the constitutive P450s that participate in carcinogen and steroid hormone metabolism, and may contribute to the anti-carcinogenic properties of this compound. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1990 journal article

Hormonal Regulation of Levels of the Messenger RNA Encoding Hepatic P450 2c (IIC11), a Constitutive Male-Specific Form of Cytochrome P450

Molecular Endocrinology, 4(2), 295–303.

By: R. Janeczko*, D. Waxman, G. Le Blanc, A. Morville & M. Adesnik

MeSH headings : Aging / genetics; Alpha-Globulins / genetics; Alpha-Globulins / metabolism; Androgens / pharmacology; Androgens / physiology; Animals; Base Sequence; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DNA / analysis; DNA / genetics; Estrogens / pharmacology; Estrogens / physiology; Gene Expression Regulation, Enzymologic; Genetic Vectors; Growth Hormone / pharmacology; Growth Hormone / physiology; Immunoblotting; Liver / enzymology; Male; Orchiectomy; Pituitary Gland / physiology; RNA, Messenger / drug effects; RNA, Messenger / genetics; Rats; Rats, Inbred Strains; Sex Characteristics; Steroid 16-alpha-Hydroxylase; Transcription, Genetic / drug effects
TL;DR: A dependence on adult androgen was demonstrated by the 2- to 4-fold decrease in P-450 2c mRNA levels after castration of adult male rats and their restoration to normal by administration of the synthetic androgen methyltrienolone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 16, 2021

1990 journal article

Mechanisms of cyclophosphamide action on hepatic P-450 expression

Cancer Research, 50(18), 5720–5726.

By: G. Le Blanc & D. Waxman

Source: NC State University Libraries
Added: November 16, 2021

1990 journal article

Pituitary Regulation of the Male-Specific Steroid 6β-Hydroxylase P-450 2a (gene product IIIA2) in Adult Rat Liver. Suppressive Influence of Growth Hormone and Thyroxine Acting at a Pretranslational Level

Molecular Endocrinology, 4(3), 447–454.

By: D. Waxman*, P. Ram*, G. Notani Gur*, G. Le Blanc*, J. Alberta*, J. Morrissey*, S. Sundseth*

MeSH headings : Animals; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Female; Gene Expression Regulation, Enzymologic / drug effects; Gene Expression Regulation, Enzymologic / physiology; Growth Hormone / physiology; Hypophysectomy; Liver / enzymology; Male; Pituitary Gland / physiology; Protein Biosynthesis / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Rats, Inbred Strains; Steroid Hydroxylases / genetics; Steroid Hydroxylases / metabolism; Thyroxine / physiology
TL;DR: Northern blot analysis revealed that T4, but not ACTH or human CG, can act in concert with GH to effect a more complete suppression of hepatic P-450 IIIA2 mRNA and protein in hypophysectomized rats, suggesting that other pituitary-dependent factors contribute to the suppression observed in the intact rats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 16, 2021

1990 journal article

Regulation and ligand-binding specificities of two sex-specific bile acid-binding proteins of rat liver cytosol.

Journal of Biological Chemistry, 265(10), 5654–5661.

By: G. LeBlanc* & D. Waxman*

TL;DR: Rat liver cytosolic proteins were photoaffinity labeled with the synthetic steroid [3H]methyltrienolone in order to identify and characterize hepatic proteins that may participate in the intracellular binding and transport of steroid hormones and other sterols and it is proposed that SBP31 and SBP34 function in the intruder binding and/or transport of bile acids. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: October 28, 2021

1989 journal article

Female-Predominant Rat Hepatic P-450 Forms j (IIE1) and 3 (IIA1) Are under Hormonal Regulatory Controls Distinct from Those of the Sex-Specific P-450 Forms

Endocrinology, 124(6), 2954–2966.

By: D. Waxman*, J. Morrissey* & G. Leblanc*

MeSH headings : Aging; Animals; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Estrenes / pharmacology; Female; Growth Hormone / pharmacology; Hypophysectomy; Isoenzymes / genetics; Isoenzymes / metabolism; Liver / growth & development; Male; Metribolone; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Orchiectomy; Ovariectomy; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reference Values; Sex Factors
TL;DR: These studies demonstrate that these female-predominant hepatic P-450 enzymes are regulated by different mechanisms, and that both are under hormonal regulatory controls distinct from those that govern expression of the female-specific hepatic enzymes. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1989 journal article

Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver. Pituitary control of hepatic NADPH cytochrome P-450 reductase

Molecular Pharmacology, 35(4), 519–525.

By: D. Waxman, J. Morrissey & G. Le Blanc

Source: NC State University Libraries
Added: November 16, 2021

1989 journal article

Interaction of Anticancer Drugs with Hepatic Monooxygenase Enzymes

Drug Metabolism Reviews, 20(2-4), 395–439.

By: G. LeBlanc* & D. Waxman*

MeSH headings : Animals; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biotransformation; Cytochrome P-450 Enzyme System / metabolism; Humans; Liver / drug effects; Liver / enzymology; Mixed Function Oxygenases / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1989 journal article

Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone

Archives of Biochemistry and Biophysics, 271(2), 508–514.

By: H. Yeowell*, D. Waxman*, G. LeBlanc*, P. Linko* & J. Goldstein*

MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases; Chorionic Gonadotropin / pharmacology; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Estrenes / pharmacology; Gonadotropin-Releasing Hormone / pharmacology; Hypothalamus / drug effects; Hypothalamus / physiology; Liver / enzymology; Male; Metribolone; Microsomes, Liver / enzymology; Orchiectomy; Pituitary Gland / drug effects; Pituitary Gland / physiology; Polychlorinated Biphenyls / pharmacology; RNA, Messenger / metabolism; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases / metabolism; Testis / drug effects; Testis / physiology; Testosterone / blood
TL;DR: The present study demonstrates that the consequential reduction in serum testosterone levels in HCB-treated rats is not causally related to the reduction in hepatic P450 2c levels, indicating that HCB must also act on some other regulatory mechanism involved in the expression of this protein. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1988 journal article

Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression

The Journal of Biological Chemistry, 263(23), 11396–11406.

By: D. Waxman*, G. Le Blanc*, J. Morrissey*, J. Staunton* & D. Lapenson*

TL;DR: Rat hepatic cytochrome P-450 form RLM2 is a testosterone 15 alpha-hydroxylase reported to be male-specific on the basis of purification studies and its adult male- specific expression is imprinted (programmed) in response to neonatal testosterone exposure. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: November 24, 2021

1988 journal article

Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes

The Journal of Biological Chemistry, 263(30), 15732–15739.

By: G. Le Blanc* & D. Waxman*

TL;DR: The studies establish that the effects of cisplatin on hepatic P-450 enzyme expression result from its interruption of the hypothalamic-pituitary stimulation of testicular androgen production and that this, in turn, leads to a depletion of circulating androgens required for maintenance of normal P- 450 enzyme expression in adult male rats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: November 24, 2021

1988 journal article

Induction of cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl

Molecular Pharmacology, 33(3), 272–278.

By: H. Yeowell, D. Waxman, G. Le Blanc, P. Linko & J. Goldstein

Source: NC State University Libraries
Added: November 16, 2021

1988 journal article

Relationships between the structures of chlorinated phenols, their toxicity, and their ability to induce glutathione S-transferase activity in Daphnia magna

Aquatic Toxicology, 12(2), 147–155.

By: G. LeBlanc*, B. Hilgenberg* & B. Cochrane*

TL;DR: It is suggested that in fact all of these compounds act in a similar manner internally to modulate enzyme activity, and that apparent differences in activity are a reflection of differences in bioconcentration of the different compounds. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1987 journal article

A rapid method for staining proteins in acrylamide gels

Analytical Biochemistry, 161(1), 172–175.

By: G. LeBlanc* & B. Cochrane*

MeSH headings : Electrophoresis, Polyacrylamide Gel / methods; Glutathione; Nitroblue Tetrazolium; Oxidation-Reduction; Proteins / isolation & purification; Rosaniline Dyes; Staining and Labeling / methods
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1987 journal article

Identification of multiple glutathione S-tansferases from Daphnia magna

Comparative Biochemistry and Physiology. B, Comparative Biochemistry, 88(1), 39–45.

By: G. Le Blanc* & B. Cochrane*

MeSH headings : Animals; Chromatography, Affinity; Chromatography, Ion Exchange; Daphnia / enzymology; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase / isolation & purification; Glutathione Transferase / metabolism; Isoenzymes / isolation & purification; Isoenzymes / metabolism; Kinetics; Molecular Weight
TL;DR: Analysis of inhibition of separated isoforms reveals that form 4 is most strongly inhibited by these chlorinated phenols, with forms 5 and 6 being inhibited to a lesser degree. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2021

1987 journal article

The genetics of xenobiotic metabolism in Drosophila—IV: Purification and characterization of the major glutathione S-transferase

Insect Biochemistry, 17(5), 731–738.

By: B. Cochrane*, J. Morrissey* & G. LeBlanc*

TL;DR: The results suggest that, in this species of Drosophila melanogaster, a single enzyme has evolved that possesses many of the properties of the multiple isozymes of higher organisms. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

1986 journal article

The genetics of xenobiotic metabolism in Drosophila. I. Genetics and environmental factors affecting glutathione S-transferase in larvae

Biochemical Pharmacology, 35(10), 1679–1684.

By: B. Cochrane* & G. LeBlanc*

MeSH headings : Benzene Derivatives / pharmacology; Chromosome Mapping; Dinitrochlorobenzene / metabolism; Drosophila melanogaster / enzymology; Drosophila melanogaster / genetics; Ethacrynic Acid / metabolism; Glutathione Transferase / analysis; Glutathione Transferase / genetics; Hydrogen-Ion Concentration; Isoenzymes / analysis; Larva / enzymology; Substrate Specificity
TL;DR: Comparison of lines of known genetic composition indicates that the degree of response to PMB is modulated by genes on chromosome II, and that differences exist with respect to the patterns of response of activities towards the substrates 1-chloro-2, 4-dinitrobenzene and ethacrynic acid. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

1985 chapter

A Method of Assessing the Toxicity of Contaminated Freshwater Sediments

In R. D. Cardwell, R. Purdy, & R. B. Comotto (Eds.), Aquatic Toxicology and Hazard Assessment: Seventh Symposium (pp. 269–283).

By: G. LeBlanc* & D. Surprenant*

Ed(s): R. Cardwell, R. Purdy & R. Comotto

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: October 29, 2020

1985 journal article

Effects of copper on the competitive interactions of two species of cladocera

Environmental Pollution Series A, Ecological and Biological, 37(1), 13–25.

By: G. LeBlanc*

TL;DR: This study, in conjunction with others, suggests that D. magna population growth is augmented by the presence of low levels of copper, and the inhibiting effect of copper on D. pulex population growth relieves D. Magna of the competitive inhibition experienced when these species are together. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1985 journal article

Modulation of substrate-specific glutathione S-transferase activity in daphnia magna with concomitant effects on toxicity tolerance

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 82(1), 37–42.

By: G. Leblanc* & B. Cochrane*

MeSH headings : Animals; Daphnia / drug effects; Daphnia / enzymology; Dinitrochlorobenzene / pharmacology; Enzyme Induction / drug effects; Epoxy Compounds / pharmacology; Ethacrynic Acid / pharmacology; Glutathione Transferase / metabolism; Nitrobenzenes / pharmacology; Nitrophenols / pharmacology; Pentachlorophenol / pharmacology; Substrate Specificity
TL;DR: Preexposure of daphnids to CDNB or PCP increased the organisms' tolerance to the toxic effects of PCP, but not CDNB, and GST activity towards CDNB and EA was biochemically separated into different protein fractions suggesting the existence of two distinct isozymes. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1984 journal article

Antimony and thallium toxicity to embryos and larvae of fathead minnows (Pimephales promelas)

Bulletin of Environmental Contamination and Toxicology, 32(1), 565–569.

By: G. LeBlanc* & J. Dean

MeSH headings : Animals; Antimony / toxicity; Carps / physiology; Cyprinidae / physiology; Embryo, Nonmammalian / drug effects; Larva / drug effects; Thallium / toxicity
TL;DR: The purpose of this study was to assess the effects of these metals on the embryos and larvae of fathead minnows (Pimephales promelas). (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1984 chapter

Comparative structure-toxicity relationships between acute and chronic effects to aquatic organisms

In K. L. E. Kaiser (Ed.), QSAR in Environmental Toxicology (pp. 245–260). Dordrecht, Holland: Reidel Publishing Company.

By: G. Le Blanc

Ed(s): K. Kaiser

Source: NC State University Libraries
Added: November 24, 2021

1984 journal article

Interspecies relationships in acute toxicity of chemicals to aquatic organisms

Environmental Toxicology and Chemistry, 3(1), 47–60.

By: G. Leblanc*

TL;DR: The acute sensitivities of several species of aquatic organisms to chemicals categorized as nonpesticide organics, pesticides and metals were correlated using polynomial regression analyses, and the mode of toxicity of metals seems to be the same among species, although the degree of toxicity may differ. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1984 journal article

The influence of mineral salts on the fecundity of the water flea (Daphnia magna) and the implications on toxicity testing of industrial wastewater

Hydrobiologia, 108, 25–31.

By: G. Le Blanc & D. Surprenant

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2021

1984 journal article

The influence of speciation on the toxicity of silver to fathead minnow (Pimephales promelas)

Environmental Toxicology and Chemistry, 3(1), 37–46.

By: G. Leblanc*, J. Mastone, A. Paradice, B. Wilson, H. Jr & K. Robillard*

Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1983 journal article

The acute and chronic toxicity of acetone, dimethyl formamide, and triethylene glycol to Daphnia magna (Straus)

Archives of Environmental Contamination and Toxicology, 12(3), 305–310.

By: G. LeBlanc* & D. Surprenant

TL;DR: All three solvents used to facilitate the solubilization of lipophilic compounds during acute toxicity tests were sufficiently low in toxicity to suggest that the recommended usage limits are adequate for the prevention of solvent related toxicity to D. magna. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1983 chapter

The effects of food concentration, animal interactions and water volume on survival, growth, and reproduction of Daphnia magna under flow-through conditions

In W. E. Bishop, R. D. Cardwell, & B. B. Heidolph (Eds.), Aquatic Toxicology and Hazard Assessment (pp. 494–508). Philadelphia: American Society for Testing and Materials.

By: G. Le Blanc, D. Schoenfeld & D. Surprenant

Ed(s): W. Bishop, R. Cardwell & B. Heidolph

Source: NC State University Libraries
Added: November 24, 2021

1982 journal article

Laboratory investigation into the development of resistance of Daphnia magna (strauus) to environmental pollutants

Environmental Pollution Series A, Ecological and Biological, 27(4), 309–322.

By: G. LeBlanc*

TL;DR: It was demonstrated that daphnids pre-exposed to copper, lead or zinc for 20 h had become significantly resistant to the toxic effects of these metals, while tests performed with sodium lauryl sulphate resulted in no increased resistance. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1981 journal article

Acute toxicity of priority pollutants to bluegill (Lepomis macrochirus)

Bulletin of Environmental Contamination and Toxicology, 26(1), 446–452.

By: R. Buccafusco, S. Ells* & G. LeBlanc*

MeSH headings : Animals; Fishes / physiology; Fresh Water / analysis; Hydrogen-Ion Concentration; Lethal Dose 50; Oxygen / analysis; Solubility; Water Pollutants / toxicity; Water Pollutants, Chemical / toxicity
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1980 journal article

Acute toxicity of priority pollutants to water flea (Daphnia magna)

Bulletin of Environmental Contamination and Toxicology, 24(1), 684–691.

By: G. LeBlanc*

MeSH headings : Daphnia / drug effects; Humans; Lethal Dose 50; Water Pollutants / toxicity; Water Pollutants, Chemical / toxicity
TL;DR: Water flea are commonly used organisms in aquatic toxicity tests, and their susceptibility to contaminants in the aquatic environment tends to be representative of freshwater zooplankton. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1980 journal article

An environmental safety assessment of butyl benzyl phthalate

Environmental Science & Technology, 14(3), 301–305.

By: W. Gledhill, R. Kaley, W. Adams, O. Hicks, P. Michael, V. Saeger, G. LeBlanc*

Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1979 journal article

Utilization of bacterial colony counters to count early instar water fleas (Daphnia magna)

Bulletin of Environmental Contamination and Toxicology, 23(1), 837–839.

By: G. LeBlanc*

MeSH headings : Animals; Bacteriological Techniques / instrumentation; Daphnia / physiology
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1978 report

The chronic toxicity of methomyl, propachlor, baygon, and baytex to aquatic organisms

[68-03-0310]. Duluth, Minnesota: U.S. Environmental Protection Agency.

By: S. Sauter, G. Le Blanc, S. Ells & K. Buxton

Source: NC State University Libraries
Added: November 24, 2021

1977 report

Acute toxicity of HMX to aquatic organisms

(Contract No. DAMD-17-74-C-4101). Fort Detrick, Maryland: U.S. Army Medical Research and Development Command.

By: R. Bentley, J. Dean, S. Ells, T. Hollister, G. Le Blanc, S. Sauter, B. Sleight

Source: NC State University Libraries
Added: November 24, 2021

1977 report

Laboratory Evaluation of the Toxicity of Cyclotrimethylene Trinitramine (RDX) to Aquatic Organisms

(Contract No. DAMD-17-74-C-4101).

By: R. Bentley, J. Dean, S. Ells, T. Hollister, G. Le Blanc, S. Sauter, B. Sleight III

TL;DR: Results of static acute toxicity tests indicate that the acute LC50 values are greater than 3 mg/1 RDX, and a water quality criterion of 0.35 mg/ 1 RDX is proposed. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: October 29, 2020

1976 report

Acute toxicity of diisopropylmethyl phosphate and dichloropentadiene to aquatic organisms

(Contract No. DAMD-17-75-C-5073). Fort Detrick, Maryland: U.S. Army Medical Research and Development Command.

By: R. Bentley, G. Le Blanc, T. Hollister & B. Sleight

Source: NC State University Libraries
Added: November 24, 2021

1976 report

Laboratory evaluation of the toxicity of nitrocellulose to aquatic organisms

(Contract No. DAMD-17-74-C-401). Fort Derrick, Maryland: U.S. Army Medical Research and Development Command.

By: R. Bentley, G. Le Blanc, T. Hollister & B. Sleight

Source: NC State University Libraries
Added: November 24, 2021

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