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TOXICOLOGICAL SCIENCES, 123(1), 71–79. https://doi.org/10.1093/toxsci/kfr154 LeBlanc, G. A. (2010). Acute Toxicity. In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 225–236). Hoboken, NJ: Wiley. Le Blanc, G. A. (2010). Elimination of Toxicants. In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 213–222). Hoboken, NJ: Wiley. LeBlanc, G. A. (2010). Endocrine Toxicology. In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 345–362). Hoboken, NJ: Wiley. Sternberg, R. M., Gooding, M. P., Hotchkiss, A. K., & LeBlanc, G. A. (2010). [Review of Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs]. ECOTOXICOLOGY, 19(1), 4–23. https://doi.org/10.1007/s10646-009-0397-z Hannas, B. R., & LeBlanc, G. A. (2010). Expression and ecdysteroid responsiveness of the nuclear receptors HR3 and E75 in the crustacean Daphnia magna. 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Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. Toxicology and Applied Pharmacology, 141(1), 288–298. https://doi.org/10.1016/s0041-008x(96)80035-4 Bain, L. J., & LeBlanc, G. A. (1996). Mobilization of Pentachlorophenol by GlutathioneS-Transferase μ Increases Cellular Toxicity. Pesticide Biochemistry and Physiology, 54(1), 65–72. https://doi.org/10.1006/pest.1996.0010 Dunn, S. E., Hughes, C. S., LeBlanc, G. A., & Cullen, J. M. (1996). Overexpression of ap-glycoprotein in hepatocellular carcinomas from woodchuck hepatitis virus-infected woodchucks (Marmota monax). Hepatology, 23(4), 662–668. https://doi.org/10.1002/hep.510230402 Parks, L. G., & LeBlanc, G. A. (1996). Reductions in steroid hormone biotransformation/elimination as a biomarker of pentachlorophenol chronic toxicity. Aquatic Toxicology, 34(4), 291–303. https://doi.org/10.1016/0166-445x(95)00045-6 Christensen, J. G., & Le Blanc, G. A. (1996). Reversal of multi-drug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol. Cancer Research, 56(3), 574–581. LeBlanc, G. A. (1995). Are environmental sentinels signaling? Environmental Health Perspectives, 103(10), 888–890. https://doi.org/10.1289/ehp.95103888 Baldwin, W. S., Milam, D. L., & LeBlanc, G. A. (1995). PHYSIOLOGICAL AND BIOCHEMICAL PERTURBATIONS IN DAPHNIA MAGNA FOLLOWING EXPOSURE TO THE MODEL ENVIRONMENTAL ESTROGEN DIETHYLSTILBESTROL. Environmental Toxicology and Chemistry, 14(6), 945. https://doi.org/10.1897/1552-8618(1995)14[945:pabpid]2.0.co;2 Le Blanc, G. A. (1995). Subtle effects: devastating consequences. SETAC News, 15(3), 30–31. LeBlanc, G. A. (1995). Trophic-Level Differences in the Bioconcentration of Chemicals: Implications in Assessing Environmental Biomagnification. Environmental Science & Technology, 29(1), 154–160. https://doi.org/10.1021/es00001a020 LeBlanc, G. A. (1994). Assessing deleterious ecosystem-level effects of environmental pollutants as a means of avoiding evolutionary consequences. Environmental Health Perspectives, 102(3), 266–267. https://doi.org/10.1289/ehp.94102266 Le Blanc, G. A., Stuart, J. D., Dunn, S. E., & Baldwin, W. S. (1994). Effect of the plant compound indole-3-carbinol on hepatic cholesterol homoeostasis. Food and Chemical Toxicology, 32(7), 633–639. https://doi.org/10.1016/0278-6915(94)90007-8 LeBlanc, G. A. (1994). Hepatic vectorial transport of xenobiotics. Chemico-Biological Interactions, 90(2), 101–120. https://doi.org/10.1016/0009-2797(94)90097-3 Dunn, S. E., & LeBlanc, G. A. (1994). Hypocholesterolemic properties of plant indoles. Biochemical Pharmacology, 47(2), 359–364. https://doi.org/10.1016/0006-2952(94)90027-2 Baldwin, W. S., & LeBlanc, G. A. (1994). IDENTIFICATION OF MULTIPLE STEROID HYDROXYLASES IN DAPHNIA MAGNA AND THEIR MODULATION BY XENOBIOTICS. Environmental Toxicology and Chemistry, 13(7), 1013. https://doi.org/10.1897/1552-8618(1994)13[1013:iomshi]2.0.co;2 Baldwin, W. S., & LeBlanc, G. A. (1994). In vivo biotransformation of testosterone by phase I and II detoxication enzymes and their modulation by 20-hydroxyecdysone in Daphnia magna. Aquatic Toxicology, 29(1-2), 103–117. https://doi.org/10.1016/0166-445x(94)90051-5 Le Blanc, G. A., & Gillette, J. S. (1993). Elevation of serum cholesterol levels in mice by the antioxidant butylated hydroxyanisole. Biochemical Pharmacology, 45(2), 513–515. https://doi.org/10.1016/0006-2952(93)90090-J Leblanc, G. A., Kantoff, P. W., Ng, S.-F., Frei, E., & Waxman, D. J. (1992). Hormonal perturbations in patients with testicular cancer treated with cisplatin. Cancer, 69(9), 2306–2310. https://doi.org/10.1002/1097-0142(19920501)69:9<2306::aid-cncr2820690917>3.0.co;2-f Danger, D. P., Baldwin, W. S., & LeBlanc, G. A. (1992). Photoaffinity labelling of steroid-hormone-binding glutathione S-transferases with [3H]methyltrienolone. Inhibition of steroid-binding activity by the anticarcinogen indole-3-carbinol. Biochemical Journal, 288(2), 361–367. https://doi.org/10.1042/bj2880361 Le Blanc, G. A., Sundseth, S. S., Weber, G. F., & Waxman, D. J. (1992). Platinum Anticancer Drugs Modulate P-450 mRNA Levels and Differentially Alter Hepatic Drug and Steroid Hormone Metabolism in Male and Female Rats. Cancer Research, 52(3), 540–547. Baldwin, W. S., & Leblanc, G. A. (1992). The anti-carcinogenic plant compound indole-3-carbinol differentially modulates P450-mediated steroid hydroxylase activities in mice. Chemico-Biological Interactions, 83(2), 155–169. https://doi.org/10.1016/0009-2797(92)90043-k Janeczko, R., Waxman, D. J., Le Blanc, G. A., Morville, A., & Adesnik, M. (1990). Hormonal Regulation of Levels of the Messenger RNA Encoding Hepatic P450 2c (IIC11), a Constitutive Male-Specific Form of Cytochrome P450. Molecular Endocrinology, 4(2), 295–303. https://doi.org/10.1210/mend-4-2-295 Le Blanc, G. A., & Waxman, D. J. (1990). Mechanisms of cyclophosphamide action on hepatic P-450 expression. Cancer Research, 50(18), 5720–5726. Waxman, D. J., Ram, P. A., Notani Gur, G., Le Blanc, G. A., Alberta, J. A., Morrissey, J. J., & Sundseth, S. S. (1990). Pituitary Regulation of the Male-Specific Steroid 6β-Hydroxylase P-450 2a (gene product IIIA2) in Adult Rat Liver. Suppressive Influence of Growth Hormone and Thyroxine Acting at a Pretranslational Level. Molecular Endocrinology, 4(3), 447–454. https://doi.org/10.1210/mend-4-3-447 LeBlanc, G. A., & Waxman, D. J. (1990). Regulation and ligand-binding specificities of two sex-specific bile acid-binding proteins of rat liver cytosol. Journal of Biological Chemistry, 265(10), 5654–5661. https://doi.org/10.1016/S0021-9258(19)39412-8 Waxman, D. J., Morrissey, J. J., & Leblanc, G. A. (1989). Female-Predominant Rat Hepatic P-450 Forms j (IIE1) and 3 (IIA1) Are under Hormonal Regulatory Controls Distinct from Those of the Sex-Specific P-450 Forms. Endocrinology, 124(6), 2954–2966. https://doi.org/10.1210/endo-124-6-2954 Waxman, D. J., Morrissey, J. J., & Le Blanc, G. A. (1989). Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver. Pituitary control of hepatic NADPH cytochrome P-450 reductase. Molecular Pharmacology, 35(4), 519–525. LeBlanc, G. A., & Waxman, D. J. (1989). Interaction of Anticancer Drugs with Hepatic Monooxygenase Enzymes. Drug Metabolism Reviews, 20(2-4), 395–439. https://doi.org/10.3109/03602538909103550 Yeowell, H. N., Waxman, D. J., LeBlanc, G. A., Linko, P., & Goldstein, J. A. (1989). Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. Archives of Biochemistry and Biophysics, 271(2), 508–514. https://doi.org/10.1016/0003-9861(89)90302-0 Waxman, D. J., Le Blanc, G. A., Morrissey, J. J., Staunton, J., & Lapenson, D. P. (1988). Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. The Journal of Biological Chemistry, 263(23), 11396–11406. https://doi.org/10.1016/S0021-9258(18)37970-5 Le Blanc, G. A., & Waxman, D. J. (1988). Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes. The Journal of Biological Chemistry, 263(30), 15732–15739. https://doi.org/10.1016/S0021-9258(19)37649-5 Yeowell, H. N., Waxman, D. J., Le Blanc, G. A., Linko, P., & Goldstein, J. A. (1988). Induction of cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl. Molecular Pharmacology, 33(3), 272–278. LeBlanc, G. A., Hilgenberg, B., & Cochrane, B. J. (1988). Relationships between the structures of chlorinated phenols, their toxicity, and their ability to induce glutathione S-transferase activity in Daphnia magna. Aquatic Toxicology, 12(2), 147–155. https://doi.org/10.1016/0166-445x(88)90032-x LeBlanc, G. A., & Cochrane, B. J. (1987). A rapid method for staining proteins in acrylamide gels. Analytical Biochemistry, 161(1), 172–175. https://doi.org/10.1016/0003-2697(87)90668-3 Le Blanc, G. A., & Cochrane, B. J. (1987). Identification of multiple glutathione S-tansferases from Daphnia magna. Comparative Biochemistry and Physiology. B, Comparative Biochemistry, 88(1), 39–45. https://doi.org/10.1016/0305-0491(87)90076-9 Cochrane, B. J., Morrissey, J. J., & LeBlanc, G. A. (1987). The genetics of xenobiotic metabolism in Drosophila—IV: Purification and characterization of the major glutathione S-transferase. Insect Biochemistry, 17(5), 731–738. https://doi.org/10.1016/0020-1790(87)90043-6 Cochrane, B. J., & LeBlanc, G. A. (1986). The genetics of xenobiotic metabolism in Drosophila. I. Genetics and environmental factors affecting glutathione S-transferase in larvae. Biochemical Pharmacology, 35(10), 1679–1684. https://doi.org/10.1016/0006-2952(86)90323-0 LeBlanc, G. A., & Surprenant, D. C. (1985). A Method of Assessing the Toxicity of Contaminated Freshwater Sediments. In R. D. Cardwell, R. Purdy, & R. B. Comotto (Eds.), Aquatic Toxicology and Hazard Assessment: Seventh Symposium (pp. 269–283). https://doi.org/10.1520/stp36272s LeBlanc, G. A. (1985). Effects of copper on the competitive interactions of two species of cladocera. Environmental Pollution Series A, Ecological and Biological, 37(1), 13–25. https://doi.org/10.1016/0143-1471(85)90021-2 Leblanc, G. A., & Cochrane, B. J. (1985). Modulation of substrate-specific glutathione S-transferase activity in daphnia magna with concomitant effects on toxicity tolerance. 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The influence of mineral salts on the fecundity of the water flea (Daphnia magna) and the implications on toxicity testing of industrial wastewater. Hydrobiologia, 108, 25–31. https://doi.org/10.1007/BF00028179 Leblanc, G. A., Mastone, J. D., Paradice, A. P., Wilson, B. F., Jr, H. B. L., & Robillard, K. A. (1984). The influence of speciation on the toxicity of silver to fathead minnow (Pimephales promelas). Environmental Toxicology and Chemistry, 3(1), 37–46. https://doi.org/10.1002/etc.5620030106 LeBlanc, G. A., & Surprenant, D. C. (1983). The acute and chronic toxicity of acetone, dimethyl formamide, and triethylene glycol to Daphnia magna (Straus). Archives of Environmental Contamination and Toxicology, 12(3), 305–310. https://doi.org/10.1007/bf01059407 Le Blanc, G. A., Schoenfeld, D. A., & Surprenant, D. C. (1983). The effects of food concentration, animal interactions and water volume on survival, growth, and reproduction of Daphnia magna under flow-through conditions. In W. E. Bishop, R. D. Cardwell, & B. B. Heidolph (Eds.), Aquatic Toxicology and Hazard Assessment (pp. 494–508). Philadelphia: American Society for Testing and Materials. LeBlanc, G. A. (1982). Laboratory investigation into the development of resistance of Daphnia magna (strauus) to environmental pollutants. Environmental Pollution Series A, Ecological and Biological, 27(4), 309–322. https://doi.org/10.1016/0143-1471(82)90159-3 Buccafusco, R. J., Ells, S. J., & LeBlanc, G. A. (1981). Acute toxicity of priority pollutants to bluegill (Lepomis macrochirus). Bulletin of Environmental Contamination and Toxicology, 26(1), 446–452. https://doi.org/10.1007/bf01622118 LeBlanc, G. A. (1980). Acute toxicity of priority pollutants to water flea (Daphnia magna). Bulletin of Environmental Contamination and Toxicology, 24(1), 684–691. https://doi.org/10.1007/bf01608174 Gledhill, W. E., Kaley, R. G., Adams, W. J., Hicks, O., Michael, P. R., Saeger, V. W., & LeBlanc, G. A. (1980). An environmental safety assessment of butyl benzyl phthalate. Environmental Science & Technology, 14(3), 301–305. https://doi.org/10.1021/es60163a001 LeBlanc, G. A. (1979). Utilization of bacterial colony counters to count early instar water fleas (Daphnia magna). Bulletin of Environmental Contamination and Toxicology, 23(1), 837–839. https://doi.org/10.1007/bf01770051 Sauter, S., Le Blanc, G. A., Ells, S. J., & Buxton, K. (1978). The chronic toxicity of methomyl, propachlor, baygon, and baytex to aquatic organisms [68-03-0310]. Duluth, Minnesota: U.S. Environmental Protection Agency. Bentley, R. E., Dean, J. W., Ells, S. J., Hollister, T. A., Le Blanc, G. A., Sauter, S., & Sleight, B. H., III. (1977). Acute toxicity of HMX to aquatic organisms (Contract No. DAMD-17-74-C-4101). Fort Detrick, Maryland: U.S. Army Medical Research and Development Command. Bentley, R. E., Dean, J. W., Ells, S. J., Hollister, T. A., Le Blanc, G. A., Sauter, S., & Sleight III, B. H. (1977). Laboratory Evaluation of the Toxicity of Cyclotrimethylene Trinitramine (RDX) to Aquatic Organisms (Contract No. DAMD-17-74-C-4101). https://doi.org/10.21236/ada061730 Bentley, R. E., Le Blanc, G. A., Hollister, T. A., & Sleight, B. H., III. (1976). Acute toxicity of diisopropylmethyl phosphate and dichloropentadiene to aquatic organisms (Contract No. DAMD-17-75-C-5073). Fort Detrick, Maryland: U.S. Army Medical Research and Development Command. Bentley, R. E., Le Blanc, G. A., Hollister, T. A., & Sleight, B. H. (1976). Laboratory evaluation of the toxicity of nitrocellulose to aquatic organisms (Contract No. DAMD-17-74-C-401). Fort Derrick, Maryland: U.S. Army Medical Research and Development Command.