Works (21)
Updated: July 5th, 2023 16:03
2004 journal article
Chemotherapy followed by half-body radiation therapy for canine lymphoma
JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(5), 703–709.
author keywords: cancer; dog; multimodality therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
A retrospective analysis of 140 dogs with oral melanoma treated with external beam radiation
VETERINARY RADIOLOGY & ULTRASOUND, 44(3), 352–359.
author keywords: dog; oral malignant melanoma; radiation therapy; prognostic factors
MeSH headings : Animals; Disease-Free Survival; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Dose Fractionation, Radiation; Female; Male; Melanoma / mortality; Melanoma / veterinary; Mouth Neoplasms / mortality; Mouth Neoplasms / veterinary; Neoplasm Recurrence, Local / mortality; Neoplasm Recurrence, Local / veterinary; North Carolina / epidemiology; Records / veterinary; Retrospective Studies; Survival Analysis; Treatment Outcome
TL;DR:
External beam radiation therapy is effective in local disease control of canine oral malignant melanoma; however, the optimal fractionation scheme has yet to be determined and further investigation into novel therapies is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Preoperative radiotherapy for vaccine associated sarcoma in 92 cats
VETERINARY RADIOLOGY & ULTRASOUND, 43(5), 473–479.
author keywords: cat; vaccine-associated sarcoma; radiation therapy; preoperative irradiation
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Carboplatin / administration & dosage; Carboplatin / therapeutic use; Cat Diseases / chemically induced; Cat Diseases / drug therapy; Cat Diseases / radiotherapy; Cat Diseases / surgery; Cats; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease-Free Survival; Female; Male; Neoplasm Recurrence, Local / mortality; Neoplasm Recurrence, Local / prevention & control; Neoplasm Recurrence, Local / veterinary; North Carolina; Preoperative Care / veterinary; Records / veterinary; Retrospective Studies; Sarcoma / chemically induced; Sarcoma / mortality; Sarcoma / radiotherapy; Sarcoma / surgery; Sarcoma / veterinary; Soft Tissue Neoplasms / chemically induced; Soft Tissue Neoplasms / mortality; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / surgery; Soft Tissue Neoplasms / veterinary; Treatment Outcome; Vaccination / adverse effects; Vaccination / veterinary
TL;DR:
Preoperative irradiation is an effective treatment for cats with vaccine associated sarcoma, especially if complete excision can be accomplished following irradiation, and outcome in cats receiving carboplatin was better than all other treatment groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 article
Retrospective analysis of axial skeleton osteosarcoma in 22 large-breed dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 15, pp. 120–124.
author keywords: canine; metastasis; radiation therapy; retriever
TL;DR:
Prevalence of metastasis and median survival for large-breed dogs with axial skeleton OSA seems to be similar to that reported for large and purebred dogs with appendicular skeletons OSA, and definitive radiation therapy may have a role in the treatment of axialkeleton osteosarcoma.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Hypercalcemia in cats: A retrospective study of 71 cases (1991-1997)
JOURNAL OF VETERINARY INTERNAL MEDICINE, 14(2), 184–189.
author keywords: calcium; calcium oxalate urolithiasis; neoplasia; primary hyperparathyroidism; renal failure
TL;DR:
A retrospective study to characterize the diseases, clinical findings, and clinicopathologic and ultrasonographic findings associated with hypercalcemia in 71 cats presented to North Carolina State University Veterinary Teaching Hospital found that the majority of cats with uroliths were azotemic, their serum urea nitrogen and creatinine concentrations and urine specific gravity differed from that of Cats with renal failure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Implementation and assessment of a career and life skills program for matriculating veterinary medical students
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 217(9), 1311–1314.
MeSH headings : Adult; Education / methods; Education, Veterinary / methods; Feedback; Focus Groups / methods; Humans; Personality Inventory; Surveys and Questionnaires; Vocational Guidance / methods
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Primary irradiation of canine intracranial masses
VETERINARY RADIOLOGY & ULTRASOUND, 41(4), 377–380.
Contributors: E. Spugnini n, D. Thrall n, G. Price n, N. Sharp n, K. Munana n & R. Page n
author keywords: dog; brain tumor; radiation therapy
MeSH headings : Animals; Brain Neoplasms / diagnostic imaging; Brain Neoplasms / mortality; Brain Neoplasms / radiotherapy; Brain Neoplasms / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Glioma / diagnostic imaging; Glioma / mortality; Glioma / radiotherapy; Glioma / veterinary; Male; Meningeal Neoplasms / diagnostic imaging; Meningeal Neoplasms / mortality; Meningeal Neoplasms / radiotherapy; Meningeal Neoplasms / veterinary; Radiography; Radiotherapy / veterinary
TL;DR:
Radiation therapy is superior to medical treatment of brain tumors in dogs with steroids, is useful for tumors that are not currently operable and may be preferable to surgical resection in dogs if the mass appears infiltrative, however, 22/29 (76%) dogs died of recurrent progressive neuropathy suggestive of tumor regrowth or progression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1999 journal article
Factors influencing survival after radiotherapy of nasal tumors in 130 dogs
VETERINARY RADIOLOGY & ULTRASOUND, 40(3), 312–317.
author keywords: dog; nasal tumor; radiation therapy; cobalt; predictive factors
MeSH headings : Animals; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Multivariate Analysis; Nose Neoplasms / mortality; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Prognosis; Radiotherapy Dosage; Survival Rate
TL;DR:
In a subset of dogs that received cobalt radiation, after adjusting for age, dogs treated with a boost technique had decreased survival and in general, local control of canine nasal tumors following aggressive radiation therapy is poor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 article
Palliative radiotherapy of appendicular osteosarcoma in 95 dogs
VETERINARY RADIOLOGY & ULTRASOUND, Vol. 40, pp. 517–522.
author keywords: canine; osteosarcoma; palliative radiotherapy
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / radiotherapy; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / radiotherapy; Dogs; Dose-Response Relationship, Radiation; Female; Male; Multivariate Analysis; Osteosarcoma / drug therapy; Osteosarcoma / radiotherapy; Osteosarcoma / veterinary; Palliative Care; Probability
TL;DR:
Ninety-five dogs with either a presumptive or biopsy confirmed diagnosis of osteosarcoma received palliative radiotherapy using 60Co photons and seventy-three of the 95 dogs experienced pain relief following treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Bt resistance management
NATURE BIOTECHNOLOGY, 16(2), 144–146.
MeSH headings : Bacillus thuringiensis; Bacillus thuringiensis Toxins; Bacterial Proteins / administration & dosage; Bacterial Proteins / genetics; Bacterial Toxins; Crops, Agricultural / genetics; Endotoxins / administration & dosage; Endotoxins / genetics; Genetic Engineering; Hemolysin Proteins; Insecticide Resistance; Insecticides / administration & dosage; Pest Control, Biological; Plants, Genetically Modified
TL;DR:
A plan for reconciling the needs of the many stakeholders in Bacillus thuringiensis endotoxin-based products (including transgenic plants) is considered under the following headings: the problem of resistance, general strategies, a national forum, need for more research, funding, coordination and education, implementation of resistance management plans and conclusions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1998 journal article
Modulation of doxorubicin concentration by cyclosporin A in brain and testicular barrier tissues expressing P-glycoprotein in rats
JOURNAL OF NEURO-ONCOLOGY, 37(1), 45–54.
author keywords: cyclosporin A; blood-tissue barrier; P-glycoprotein; multidrug resistance; doxorubicin; cisplatin
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; Animals; Blood-Brain Barrier / drug effects; Brain / drug effects; Brain / metabolism; Cisplatin / administration & dosage; Cisplatin / pharmacology; Cyclosporine / administration & dosage; Cyclosporine / pharmacology; Doxorubicin / pharmacokinetics; Evans Blue / pharmacokinetics; Fluorescein / pharmacokinetics; Horseradish Peroxidase / pharmacokinetics; Injections, Intravenous; Injections, Subcutaneous; Male; Platinum / pharmacokinetics; Rats; Rats, Inbred F344; Testis / drug effects; Testis / metabolism; Tissue Distribution / drug effects
TL;DR:
Modulation of Pgp function may prove to be useful for improving chemotherapy efficacy for patients with malignancies affecting tissues with blood-tissue barriers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Potential complications associated with normothermic lonidamine infusion and with systemic acidosis in dogs receiving lonidamine during whole body hyperthermia (WBH)
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 14(3), 271–283.
author keywords: lonidamine; whole body hyperthermia; vascular toxicosis; systemic pH; haemorrhage
MeSH headings : Acidosis; Animals; Dogs; Hyperthermia, Induced; Indazoles / adverse effects; Radiation-Sensitizing Agents / adverse effects; Thrombosis / chemically induced; Vasculitis / chemically induced
TL;DR:
The observations confirm the results of in vitro studies which suggest that the combined effect of lonidamine and hyperthermia is enhanced under acidic conditions and indicate that acid-base status of patients receiving l onidamine during WBH must be monitored carefully to avoid serious complications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Radiation therapy for incompletely resected canine mast cell tumors
VETERINARY RADIOLOGY & ULTRASOUND, 39(1), 57–62.
author keywords: canine; mast cell neoplasia; megavoltage radiation
MeSH headings : Adrenal Cortex Hormones / therapeutic use; Age Factors; Animals; Cobalt Radioisotopes / therapeutic use; Disease-Free Survival; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dog Diseases / surgery; Dogs; Dose Fractionation, Radiation; Female; Follow-Up Studies; Lymph Nodes / radiation effects; Lymphatic Metastasis / radiotherapy; Male; Mast-Cell Sarcoma / pathology; Mast-Cell Sarcoma / radiotherapy; Mast-Cell Sarcoma / secondary; Mast-Cell Sarcoma / surgery; Mast-Cell Sarcoma / veterinary; Neoplasm Recurrence, Local / pathology; Neoplasm Recurrence, Local / veterinary; Neoplasm Staging / veterinary; Neoplasm, Residual / radiotherapy; Neoplasm, Residual / veterinary; Neoplasms, Second Primary / pathology; Neoplasms, Second Primary / veterinary; Radiopharmaceuticals / therapeutic use; Radiotherapy Dosage / veterinary; Radiotherapy, High-Energy / veterinary; Retrospective Studies; Sex Factors; Skin Neoplasms / pathology; Skin Neoplasms / radiotherapy; Skin Neoplasms / surgery; Skin Neoplasms / veterinary; Survival Rate; Time Factors
TL;DR:
Data presented herein support megavoltage radiation as an effective treatment for canine mast cell neoplasia, and suggest that disease free interval in dogs treated with daily fractions may be longer than that achieved with alternating day fractions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Use of body surface area (BSA)-based dosages to calculate chemotherapeutic drug dose in dogs: I. Potential problems with current BSA formulae
JOURNAL OF VETERINARY INTERNAL MEDICINE, 12(4), 267–271.
author keywords: allometry; normalization; toxicoses
MeSH headings : Animals; Body Surface Area / veterinary; Dog Diseases / drug therapy; Dogs; Drug Administration Schedule / veterinary
TL;DR:
Results presented in this review suggest that canine BSA estimates may be inaccurate because the values for the constant (K) and exponent (a) in the formulae (BSA = K.Wa) are incorrect or because a linear parameter such as body length is lacking from the formULae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Use of body surface area to calculate chemotherapeutic drug dose in dogs: II. Limitations imposed by pharmacokinetic factors
JOURNAL OF VETERINARY INTERNAL MEDICINE, 12(4), 272–278.
author keywords: allometry; cancer chemotherapeutics; dosage regimen; dose normalization; drug excretion; metabolism
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Body Surface Area / veterinary; Dog Diseases / drug therapy; Dogs; Drug Administration Schedule / veterinary
TL;DR:
A review of the pharmacokinetic disposition of several cancer chemotherapeutics suggests that studies are needed to determine the most effective method to achieve equivalent anticancer drug concentrations in diverse veterinary patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 38(2), 129–135.
author keywords: lonidamine; pharmacokinetics; dog
MeSH headings : Administration, Oral; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / blood; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Dogs; Indazoles / administration & dosage; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Injections, Intravenous; Kinetics; Liver / drug effects; Liver / pathology; Male; Testis / drug effects; Testis / pathology; Vomiting / chemically induced
TL;DR:
The findings suggest that lonidamine is hepatotoxic in dogs, and the dose and route appears to be a viable and controllable method for prospective quantification of l onidamine interaction with systemic chemotherapy and/or hyperthermia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Phase I evaluation of mitoxantrone alone and combined with whole body hyperthermia in dogs with lymphoma
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 12(3), 309–320.
author keywords: hyperthermia; mitoxanthrone; lymphoma; canine
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Blood Cell Count / veterinary; Dogs; Female; Fever / veterinary; Lymphoma / metabolism; Lymphoma / therapy; Lymphoma / veterinary; Male; Mitoxantrone / therapeutic use; Mitoxantrone / toxicity; Neutropenia / complications; Neutropenia / veterinary; Neutrophils / metabolism; Regression Analysis; Thrombocytopenia / complications; Thrombocytopenia / veterinary
TL;DR:
It is concluded that MX may be administered without dose reduction to dogs undergoing WBH and that MX should be evaluated more thoroughly in future thermochemotherapy studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
EFFECT OF WHOLE-BODY HYPERTHERMIA ON LONIDAMINE AND DOXORUBICIN PHARMACOKINETICS AND TOXICITY IN DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11(4), 545–559.
author keywords: LONIDAMINE; DOXORUBICIN; WHOLE BODY HYPERTHERMIA; PHARMACOKINETICS; TOXICITY
MeSH headings : Animals; Antineoplastic Agents / blood; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Bile Acids and Salts / blood; Blood Chemical Analysis; Dogs; Doxorubicin / blood; Doxorubicin / pharmacokinetics; Doxorubicin / toxicity; Hyperthermia, Induced; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Liver / drug effects; Liver / ultrastructure; Metabolic Clearance Rate; Microscopy, Electron; Myocardial Contraction / drug effects; Myocardium / ultrastructure; Vacuoles / drug effects; Vacuoles / ultrastructure
TL;DR:
WBH did not decrease the maximum tolerable dose of doxorubicin when given with lonidamine, and that the antitumour activity of this combination should be assessed, but the biochemical and haematologic toxicities observed did not appear to differ in character or severity from that reported in dogs receiving lonIDamine +/- WBH or doxorbicin +/-WBH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
EFFECT OF WHOLE-BODY HYPERTHERMIA ON THE PHARMACOKINETICS AND TOXICITY OF LONIDAMINE IN DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11(4), 531–544.
author keywords: LONIDAMINE; WHOLE-BODY HYPERTHERMIA; PHARMACOKINETICS; TOXICITY; DOG
MeSH headings : Alanine Transaminase / blood; Alkaline Phosphatase / blood; Amylases / blood; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Bilirubin / blood; Blood Glucose / metabolism; Carbon Dioxide / blood; Creatine Kinase / blood; Dogs; Hyperthermia, Induced; Hypokalemia / etiology; Indazoles / administration & dosage; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Liver / drug effects; Liver / pathology; Sialorrhea / etiology; Urea / blood
TL;DR:
The pharmacokinetics and toxicity of intravenous lonidamine were investigated in dogs receiving four cycles of lonidsamine and 400 mg/m2 was identified as the maximum tolerable dose to be administered intravenously to dogs during whole-body hyperthermia (WBH).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1994 journal article
EFFECT OF WHOLE-BODY HYPERTHERMIA ON CARBOPLATIN DISPOSITION AND TOXICITY IN DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(6), 807–816.
MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / toxicity; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Female; Hematopoietic System / drug effects; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary
TL;DR:
A randomized phase II evaluation should be initiated to determine if a therapeutic gain can be achieved using combined CBDCA and WBH and further refinement of the CBDCA dose in such a trial should be based on both pharmacokinetic parameters and normal tissue response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1992 journal article
QUANTITATIVE ESTIMATION OF THE THERMAL DOSE-MODIFYING FACTOR FOR CIS-DIAMMINEDICHLOROPLATINUM (CDDP) IN TUMOR-BEARING DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 8(6), 761–769.
MeSH headings : Animals; Bone Marrow / drug effects; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Drug Tolerance; Female; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Kidney / drug effects; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary; Organoplatinum Compounds / administration & dosage; Organoplatinum Compounds / adverse effects
TL;DR:
A statistical method for estimating clinical toxicity was used to determine a theoretical isoeffect dose-modifying factor for dogs with disseminated or refractory neoplasia treated with cis-diammine dichloroplatinum (II) plus whole-body hyperthermia or CDDP alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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