Works (86)

Updated: August 23rd, 2023 21:20

2023 journal article

POInTbrowse: orthology prediction and synteny exploration for paleopolyploid genomes

BMC BIOINFORMATICS, 24(1).

By: M. Siddiqui n & G. Conant n

author keywords: POInT; Comparative genomics; Browser
MeSH headings : Humans; Synteny; Phylogeny; Genome; Genomics; Polyploidy; Evolution, Molecular
Sources: Web Of Science, ORCID
Added: June 5, 2023

2022 article

Convergent evolution of polyploid genomes from across the eukaryotic tree of life

Hao, Y., Fleming, J., Petterson, J., Lyons, E., Edger, P. P., Pires, J. C., … Conant, G. C. (2022, May 10). G3-GENES GENOMES GENETICS, Vol. 5.

By: Y. Hao*, J. Fleming n, J. Petterson n, E. Lyons*, P. Edger*, J. Pires*, J. Thorne n, G. Conant n

author keywords: polyploidy; convergent evolution; reciprocal gene loss; evolutionary model
MeSH headings : Diploidy; Eukaryota; Evolution, Molecular; Humans; Phylogeny; Polyploidy
Sources: Web Of Science, ORCID
Added: May 23, 2022

2022 journal article

Hybridization order is not the driving factor behind biases in duplicate gene losses among the hexaploid Solanaceae

By: L. McRae n, A. Beric* & G. Conant n

author keywords: Solanaceae; polyploidy; biased fractionation; hexaploidy; repetitive elements
MeSH headings : Genes, Duplicate; Polyploidy; Solanaceae / genetics; Evolution, Molecular; Brassicaceae / genetics; Bias; Genome, Plant
Sources: Web Of Science, ORCID
Added: November 14, 2022

2021 journal article

A metagenomic analysis of the effect of antibiotic feed additives on the ovine rumen metabolism

SMALL RUMINANT RESEARCH, 205.

By: R. Patil*, M. Ellison*, K. Austin*, W. Lamberson*, K. Cammack* & G. Conant n

author keywords: Rumen; Antibiotics; Metabolic network; Metagenomics; Vertebrate microbiome
Sources: Web Of Science, ORCID
Added: November 8, 2021

2021 journal article

Comparative phylogenetics of repetitive elements in a diverse order of flowering plants (Brassicales)

G3-GENES GENOMES GENETICS, 11(7).

By: A. Beric*, M. Mabry*, A. Harkess*, J. Brose*, M. Schranz*, G. Conant n, P. Edger*, B. Meyers*, J. Pires*

author keywords: Brassicales; repetitive elements; whole-genome duplication; genome size; evolution
MeSH headings : Phylogeny; Magnoliopsida / genetics; Evolution, Molecular; Genome Size; Polyploidy; Genome, Plant; DNA Transposable Elements / genetics; Plants / genetics
Sources: Web Of Science, ORCID
Added: January 18, 2022

2021 journal article

Distinct C-4 sub-types and C-3 bundle sheath isolation in the Paniceae grasses

PLANT DIRECT, 5(12).

By: J. Washburn*, J. Strable n, P. Dickinson*, S. Kothapalli*, J. Brose*, S. Covshoff*, G. Conant n, J. Hibberd*, J. Pires*

author keywords: C-4; C-4 sub-types; evolution; photosynthesis
Sources: Web Of Science, ORCID
Added: January 10, 2022

2021 journal article

Genes derived from ancient polyploidy have higher genetic diversity and are associated with domestication in Brassica rapa

NEW PHYTOLOGIST, 230(1), 372–386.

author keywords: Brassica; domestication; genetic diversity; genomics; polyploidy; whole genome duplication
MeSH headings : Brassica rapa / genetics; Domestication; Genome, Plant / genetics; Phylogeny; Polyploidy
Sources: Web Of Science, ORCID
Added: March 22, 2021

2021 journal article

The contributions from the progenitor genomes of the mesopolyploid Brassiceae are evolutionarily distinct but functionally compatible

GENOME RESEARCH, 31(5), 799–810.

By: Y. Hao n, M. Mabry*, P. Edger*, M. Freeling*, C. Zheng*, L. Jin*, R. VanBuren*, M. Colle* ...

MeSH headings : Evolution, Molecular; Genome; Genome, Plant; Humans; Hybridization, Genetic; Phylogeny; Polyploidy
Sources: Web Of Science, ORCID
Added: June 10, 2021

2020 journal article

A Single, Shared Triploidy in Three Species of Parasitic Nematodes

G3-GENES GENOMES GENETICS, 10(1), 225–233.

By: A. Schoonmaker*, Y. Hao*, D. Bird* & G. Conant n

author keywords: polyploidy; evolutionary model; root-knot nematode
MeSH headings : Animals; Evolution, Molecular; Genome, Helminth; Phylogeny; Triploidy; Tylenchoidea / classification; Tylenchoidea / genetics
Sources: Web Of Science, ORCID
Added: January 21, 2020

2020 journal article

Baby Genomics: Tracing the Evolutionary Changes That Gave Rise to Placentation

GENOME BIOLOGY AND EVOLUTION, 12(3), 35–47.

By: Y. Hao n, H. Lee*, M. Baraboo*, K. Burch*, T. Maurer*, J. Somarelli*, G. Conant n

author keywords: comparative genomics; orthology inference; mammalian pregnancy; placental mammals
MeSH headings : Animals; Evolution, Molecular; Female; Gene Expression Regulation; Genomics; Humans; Immunity, Innate / genetics; Mammals / genetics; Placentation / genetics; Pregnancy; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: June 15, 2020

2020 journal article

Phylogeny and multiple independent whole-genome duplication events in the Brassicales

AMERICAN JOURNAL OF BOTANY, 107(8), 1148–1164.

By: M. Mabry*, J. Brose*, P. Blischak*, B. Sutherland*, W. Dismukes*, C. Bottoms*, P. Edger*, J. Washburn ...

author keywords: Brassicales; Capparaceae; Cleomaceae; phylogeny; phylo-transcriptomics; Resedaceae; whole-genome duplication
MeSH headings : Evolution, Molecular; Gene Duplication; Genome; Genome, Plant / genetics; Humans; Magnoliopsida / genetics; Phylogeny; Polyploidy
Sources: Web Of Science, ORCID
Added: September 14, 2020

2020 journal article

The lasting after-effects of an ancient polyploidy on the genomes of teleosts

PLOS ONE, 15(4).

By: G. Conant n

MeSH headings : Animals; Evolution, Molecular; Fishes / classification; Fishes / genetics; Genome; Phylogeny; Polyploidy
Sources: Web Of Science, ORCID
Added: June 15, 2020

2019 journal article

Functional characterization of SMN evolution in mouse models of SMA

SCIENTIFIC REPORTS, 9.

By: E. Osman*, M. Bolding*, E. Villalon*, K. Kaifer*, Z. Lorson*, S. Tisdale*, Y. Hao n, G. Conant n ...

MeSH headings : Animals; Caenorhabditis elegans; Disease Models, Animal; Drosophila melanogaster; Evolution, Molecular; Mice; Mice, Knockout; Muscular Atrophy, Spinal / genetics; Muscular Atrophy, Spinal / metabolism; Schizosaccharomyces; Survival of Motor Neuron 1 Protein / genetics; Survival of Motor Neuron 1 Protein / metabolism; Xenopus Proteins / genetics; Xenopus Proteins / metabolism; Xenopus laevis; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
Sources: Web Of Science, ORCID
Added: July 22, 2019

2019 journal article

Predicting residual feed intake status using rumen microbial profiles in ewe lambs

JOURNAL OF ANIMAL SCIENCE, 97(7), 2878–2888.

By: M. Ellison*, G. Conant n, W. Lamberson*, K. Austin*, E. Kirk*, H. Cunningham*, D. Rule*, K. Cammack*

author keywords: feed efficiency; RFI prediction; rumen microbiome; sheep
MeSH headings : Animal Feed / analysis; Animals; Diet / veterinary; Eating; Female; Microbiota; Phenotype; Rumen / microbiology; Sheep / microbiology; Sheep / physiology
Sources: Web Of Science, ORCID
Added: July 22, 2019

2019 journal article

Transcriptome and organellar sequencing highlights the complex origin and diversification of allotetraploid Brassica napus

NATURE COMMUNICATIONS, 10.

By: H. An*, X. Qi*, M. Gaynor*, Y. Hao n, S. Gebken*, M. Mabry*, A. McAlvay*, G. Teakle* ...

MeSH headings : Brassica napus / genetics; Brassica napus / metabolism; Gene Expression Regulation, Plant; Genomics; Organelles; Phylogeny; Plant Leaves / growth & development; Plant Tubers; Ploidies; Polymorphism, Single Nucleotide; RNA, Plant / genetics; Sequence Analysis, RNA; Transcriptome
Sources: Web Of Science, ORCID
Added: July 22, 2019

2018 journal article

Author Correction: Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogenetic Tree of the Paniceae Grasses

Scientific Reports, 8(1).

Sources: Crossref, ORCID
Added: February 12, 2020

2018 article

Genome-guided phylo-transcriptomic methods and the nuclear phylogenetic tree of the paniceae grasses (vol 7, 13528, 2017)

Scientific Reports, Vol. 8.

By: J. Washburn, J. Schnable, G. Conant, T. Brutnell, Y. Shao, Y. Zhang, M. Ludwig, G. Davidse, J. Pires

Source: NC State University Libraries
Added: August 6, 2018

2018 article

Integrating Networks, Phylogenomics, and Population Genomics for the Study of Polyploidy

ANNUAL REVIEW OF ECOLOGY, EVOLUTION, AND SYSTEMATICS, VOL 49, Vol. 49, pp. 253–278.

By: P. Blischak*, M. Mabry*, G. Conant n & J. Pires*

author keywords: dosage; genome evolution; network biology; phylogenomics; polyploidy; population genomics
Sources: Web Of Science, ORCID
Added: December 10, 2018

2018 journal article

Patterns of Population Variation in Two Paleopolyploid Eudicot Lineages Suggest That Dosage-Based Selection on Homeologs Is Long-Lived

GENOME BIOLOGY AND EVOLUTION, 10(3), 999–1011.

author keywords: whole genome duplication; Arabidopsis thaliana; Brassica; dosage balance; metabolic network
MeSH headings : Arabidopsis / genetics; Brassica / genetics; Evolution, Molecular; Gene Dosage / genetics; Gene Duplication; Genes, Plant / genetics; Genome, Plant / genetics; Phylogeny; Polyploidy; Selection, Genetic / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Poor feed efficiency in sheep is associated with several structural abnormalities in the community metabolic network of their ruminal microbes

JOURNAL OF ANIMAL SCIENCE, 96(6), 2113–2124.

By: R. Patil*, M. Ellison*, S. Wolff*, C. Shearer*, A. Wright*, R. Cockrum*, K. Austin*, W. Lamberson* ...

author keywords: feed efficiency; metabolic network; metagenomics; rumen; vertebrate microbiome
MeSH headings : Animal Feed / analysis; Animals; Female; Gastrointestinal Microbiome; Metabolic Networks and Pathways; Metagenomics; Rumen / metabolism; Rumen / microbiology; Sheep / microbiology; Sheep / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Preferential retention of genes from one parental genome after polyploidy illustrates the nature and scope of the genomic conflicts induced by hybridization

PLOS GENETICS, 14(3).

By: M. Emery*, M. Willis*, Y. Hao n, K. Barry*, K. Oakgrove*, Y. Peng*, J. Schmutz*, E. Lyons* ...

MeSH headings : Brassicaceae / genetics; Evolution, Molecular; Genes, Plant; Genomic Imprinting; Hybridization, Genetic; Models, Genetic; Polyploidy
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 article

RUMINANT NUTRITION SYMPOSIUM: Tiny but mighty: the role of the rumen microbes in livestock production (vol 96, pg 752, 2018)

Cammack, K. M., Austin, K. J., Lamberson, W. R., Conant, G. C., & Cunningham, H. C. (2018, October). JOURNAL OF ANIMAL SCIENCE, Vol. 96, pp. 4481–4481.

By: K. Cammack*, K. Austin*, W. Lamberson*, G. Conant n & H. Cunningham*

Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

Tiny but mighty: The role of the rumen microbes in livestock production

Journal of Animal Science, 1.

By: K. Cammack*, K. Austin*, W. Lamberson*, G. Conant n & H. Cunningham*

author keywords: metagenomics; microbes; performance; production; rumen
MeSH headings : Animals; Archaea / genetics; Archaea / physiology; Bacteria / genetics; Bacteria / metabolism; Fungi / genetics; Fungi / physiology; Livestock / microbiology; Microbiota / genetics; Nutritional Status; Rumen / microbiology; Ruminants / microbiology; Ruminants / physiology; Virus Physiological Phenomena; Viruses / genetics
Sources: Crossref, ORCID
Added: September 28, 2019

2017 journal article

Diet and feed efficiency status affect rumen microbial profiles of sheep

SMALL RUMINANT RESEARCH, 156, 12–19.

By: M. Ellison*, G. Conant*, W. Lamberson*, R. Cockrum*, K. Austin*, D. Rule*, K. Cammack*

author keywords: Diet; Feed efficiency; Microbes; Rumen; Sheep
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Diet shifts provoke complex and variable changes in the metabolic networks of the ruminal microbiome

MICROBIOME, 5.

By: S. Wolff*, M. Ellison*, Y. Hao*, R. Cockrum*, K. Austin*, M. Baraboo*, K. Burch*, H. Lee* ...

author keywords: metagenomics; vertebrate microbiome; metabolic network
MeSH headings : Animal Feed / analysis; Animals; Diet; Digestion / physiology; Edible Grain; Feeding Behavior; Gastrointestinal Microbiome / physiology; Metabolic Networks and Pathways; Metagenomics; Rumen / microbiology; Rumen / physiology; Sheep / microbiology; Sheep / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 conference paper

Effects of evolutionary pressure on histone modifications

2017 ieee international conference on bioinformatics and biomedicine (bibm), 2267–2267.

By: S. Khan*, G. Conant n & D. Xu*

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogentic Tree of the Paniceae Grasses

SCIENTIFIC REPORTS, 7.

MeSH headings : Gene Expression Profiling; Genome, Plant; Phylogeny; Poaceae / classification; Poaceae / genetics; RNA, Plant / chemistry; RNA, Plant / isolation & purification; RNA, Plant / metabolism; Sequence Analysis, RNA
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Convergent Evolution and the Origin of Complex Phenotypes in the Age of Systems Biology

International Journal of Plant Sciences, 177(4), 305–318.

By: J. Washburn*, K. Bird, G. Conant* & J. Pires

author keywords: convergent evolution; parallel evolution; systems biology; comparative genomics; yeast; cancer; polyploidy; domestication; heterosis; C-4 photosynthesis
Sources: ORCID, Crossref
Added: September 12, 2019

2016 book

Robust Yet Fragile: Expression Noise, Protein Misfolding, and Gene Dosage in the Evolution of Genomes

In Annual Review of Genetics (Vol. 50, pp. 113–131).

By: J. Pires & G. Conant*

author keywords: dosage balance; gene expression noise; polyploidy; robustness; aneuploidy; gene duplication
MeSH headings : Aneuploidy; Animals; Biological Evolution; Gene Dosage; Gene Duplication; Gene Expression; Genome; Phenotype; Protein Folding
Source: ORCID
Added: September 12, 2019

2016 journal article

Some assembly required: evolutionary and systems perspectives on the mammalian reproductive system

Cell and Tissue Research, 363(1), 267–278.

By: B. Mordhorst*, M. Wilson* & G. Conant*

author keywords: Evolution; Reproduction; Systems biology; Metabolic modeling; Selection
MeSH headings : Animals; Biological Evolution; Genitalia / physiology; Genomics; Humans; Reproduction; Sex Chromosomes / genetics; Systems Biology
Source: ORCID
Added: September 12, 2019

2015 journal article

Patterns of gene conversion in duplicated yeast histones suggest strong selection on a coadapted macromolecular complex

Genome Biology and Evolution, 7(12), 3249–3258.

By: K. Scienski*, J. Fay & G. Conant*

author keywords: genome duplication; gene conversion; histones
MeSH headings : Evolution, Molecular; Gene Conversion; Gene Duplication; Histones / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins / genetics; Selection, Genetic
Source: ORCID
Added: September 12, 2019

2015 book

Structure, interaction, and evolution: Reflections on the natural history of proteins

In Evolutionary Biology: Biodiversification from Genotype to Phenotype (pp. 187–201).

By: G. Conant*

Source: ORCID
Added: September 12, 2019

2015 journal article

The butterfly plant arms-race escalated by gene and genome duplications

Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8362–8366.

By: P. Edger*, H. Heidel-Fischer*, M. Bekaert*, J. Rota*, G. Glöckner*, A. Platts*, D. Heckel*, J. Der* ...

author keywords: coevolution; phylogenomics; evolutionary novelty; chemical defenses; diversification
MeSH headings : Animals; Bayes Theorem; Biodiversity; Brassicaceae / classification; Brassicaceae / genetics; Brassicaceae / parasitology; Butterflies / classification; Butterflies / genetics; Butterflies / physiology; Evolution, Molecular; Gene Duplication; Gene Expression; Genes, Insect / genetics; Genes, Plant / genetics; Genetic Variation; Genome, Insect / genetics; Genome, Plant / genetics; Host-Parasite Interactions / genetics; Insect Proteins / genetics; Phylogeny; Plant Proteins / genetics; Species Specificity
Source: ORCID
Added: September 12, 2019

2015 journal article

The players may change but the game remains: Network analyses of ruminal microbiomes suggest taxonomic differences mask functional similarity

Nucleic Acids Research, 43(20), 9600–9612.

By: T. Taxis*, S. Wolff*, S. Gregg*, N. Minton*, C. Zhang*, J. Dai*, R. Schnabel*, J. Taylor* ...

MeSH headings : Animals; Cattle; DNA, Ribosomal / chemistry; Enzymes / genetics; Fatty Acids, Volatile / metabolism; Male; Metabolic Networks and Pathways; Metagenome; Metagenomics; Microbiota / genetics; Phylogeny; RNA, Ribosomal, 16S / genetics; Rumen / metabolism; Rumen / microbiology
Source: ORCID
Added: September 12, 2019

2014 journal article

Comparative genomics as a time machine: How relative gene dosage and metabolic requirements shaped the time-dependent resolution of yeast polyploidy

Molecular Biology and Evolution, 31(12), 3184–3193.

By: G. Conant*

author keywords: protein interaction network; metabolic flux; gene dosage; transcriptional regulatory network; polyploidy; Saccharomyces cerevisiae
MeSH headings : Evolution, Molecular; Gene Dosage; Gene Duplication; Gene Expression Regulation, Fungal; Genes, Duplicate; Genes, Fungal; Models, Genetic; Phylogeny; Polyploidy; Protein Interaction Maps; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins / genetics
Source: ORCID
Added: September 12, 2019

2014 journal article

Dosage, duplication, and diploidization: clarifying the interplay of multiple models for duplicate gene evolution over time

Current Opinion in Plant Biology, 19, 91–98.

By: G. Conant*, J. Birchler* & J. Pires*

MeSH headings : Diploidy; Evolution, Molecular; Gene Dosage; Gene Duplication; Plants / genetics
Sources: ORCID, Web Of Science
Added: September 12, 2019

2014 journal article

Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks

PLoS ONE, 9(1).

By: M. Bekaert* & G. Conant*

MeSH headings : Algorithms; Animals; Cluster Analysis; Gene Dosage; Gene Duplication; Genomics; Humans; Isoenzymes / chemistry; Mammals / genetics; Metabolic Networks and Pathways / genetics; Mice; Phenotype; Principal Component Analysis; Selection, Genetic
Source: ORCID
Added: September 12, 2019

2014 journal article

Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa

Cell and Tissue Research, 356(1), 261–278.

By: S. Zimmerman*, Y. Yi*, M. Sutovsky*, F. Van Leeuwen*, G. Conant* & P. Sutovsky*

author keywords: Ubiquitin; Proteasome; UBR7; C14ORF130; Spermatozoa; Fertilization; Zona pellucida; Pig; Mouse
MeSH headings : Acrosome / drug effects; Acrosome / metabolism; Animals; Antibodies, Blocking / pharmacology; Blotting, Western; Fertilization in Vitro; Fluorescent Antibody Technique; Humans; Male; Mice; Phylogeny; Protein Transport / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Spermatids / cytology; Spermatids / drug effects; Spermatids / metabolism; Spermatozoa / cytology; Spermatozoa / drug effects; Spermatozoa / enzymology; Swine; Testis / drug effects; Testis / metabolism; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
Source: ORCID
Added: September 12, 2019

2014 journal article

Large-Scale Pairwise Alignments on GPU Clusters: Exploring the Implementation Space

Journal of Signal Processing Systems, 77(1-2), 131–149.

By: H. Truong*, D. Li*, K. Sajjapongse*, G. Conant* & M. Becchi*

author keywords: Heterogeneous system; Sequence alignment; GPU
Sources: ORCID, Crossref
Added: July 20, 2019

2014 journal article

Secondary structure analyses of the nuclear rRNA internal transcribed spacers and assessment of its phylogenetic utility across the brassicaceae (mustards)

PLoS ONE, 9(7).

MeSH headings : Brassicaceae / genetics; DNA, Ribosomal Spacer / chemistry; Genes, rRNA; Nucleic Acid Conformation; Phylogeny
Source: ORCID
Added: September 12, 2019

2014 journal article

The yeast protein interaction network has a capacity for self-organization

FEBS Journal, 281(15), 3420–3432.

By: A. Dhroso*, D. Korkin* & G. Conant*

author keywords: metabolic channeling; protein interaction network; robustness; self-assembly
MeSH headings : Computer Simulation; Fungal Proteins / chemistry; Fungal Proteins / physiology; Models, Molecular; Phosphorylation; Protein Interaction Maps; Protein Processing, Post-Translational; Saccharomyces / metabolism
Source: ORCID
Added: September 12, 2019

2013 journal article

A Conserved Mammalian Protein Interaction Network

PLoS ONE, 8(1).

MeSH headings : Animals; Conserved Sequence / genetics; Evolution, Molecular; Humans; Mammals / classification; Mammals / genetics; Models, Genetic; Phylogeny; Primates / genetics; Protein Interaction Maps / genetics; Time Factors
Source: ORCID
Added: September 12, 2019

2013 conference paper

A distributed CPU-GPU framework for pairwise alignments on large-scale sequence datasets

Proceedings of the International Conference on Application-Specific Systems, Architectures and Processors, 329–338.

By: D. Li*, K. Sajjapongse*, H. Truong*, G. Conant* & M. Becchi*

Source: ORCID
Added: September 12, 2019

2013 journal article

Diet Alters Both the Structure and Taxonomy of the Ovine Gut Microbial Ecosystem

DNA Research, 21(2), 115–125.

By: M. Ellison*, G. Conant*, R. Cockrum*, K. Austin*, H. Truong*, M. Becchi*, W. Lamberson*, K. Cammack*

author keywords: Ovis aries; microbiome; 16S subunit
MeSH headings : Animals; Bacteria / classification; Bacteria / genetics; DNA, Ribosomal / genetics; Diet; Ecosystem; Metagenome; Rumen / microbiology; Sequence Analysis, DNA; Sheep / microbiology
Sources: ORCID, Crossref
Added: July 20, 2019

2013 journal article

Extreme evolutionary conservation of functionally important regions in H1N1 influenza proteome

PLoS ONE, 8(11).

By: S. Warren*, X. Wan*, G. Conant* & D. Korkin*

MeSH headings : Biological Evolution; Influenza A Virus, H1N1 Subtype / classification; Influenza A Virus, H1N1 Subtype / genetics; Influenza A Virus, H1N1 Subtype / metabolism; Phylogeny; Viral Proteins / genetics; Viral Proteins / metabolism
Source: ORCID
Added: September 12, 2019

2013 journal article

Watching the grin fade: Tracing the effects of polyploidy on different evolutionary time scales

Seminars in Cell and Developmental Biology, 24(4), 320–331.

By: D. Mayfield-Jones, J. Washburn, T. Arias, P. Edger, J. Pires & G. Conant*

author keywords: Polyploidy; WGD; Network evolution; Meiosis; Mitosis; Cancer; Warburg effect; Crabtree effect
MeSH headings : Animals; Biological Evolution; Evolution, Molecular; Genome; Humans; Plants / genetics; Polyploidy
Source: ORCID
Added: September 12, 2019

2012 journal article

Altered patterns of fractionation and exon deletions in Brassica rapa support a two-step model of paleohexaploidy

Genetics, 190(4), 1563–1574.

MeSH headings : Arabidopsis / genetics; Brassica rapa / classification; Brassica rapa / genetics; Cell Nucleus / genetics; Chromosomes, Plant / genetics; Computer Simulation; DNA, Plant / genetics; Evolution, Molecular; Exons; Genome, Plant; Models, Genetic; Molecular Sequence Data; Phylogeny; Polyploidy; Recombination, Genetic; Repetitive Sequences, Nucleic Acid; Sequence Deletion
Source: ORCID
Added: September 12, 2019

2012 journal article

Cloning and characterization of the peptidoglycan recognition protein genes in the mosquito, Armigeres subalbatus (Diptera: Culicidae)

Journal of Medical Entomology, 49(3), 656–671.

By: S. Wang*, G. Conant*, R. Ou* & B. Beerntsen*

author keywords: peptidoglycan recognition protein; Armigeres subalbatus; mosquito; AsPGRP; immune response
MeSH headings : Animals; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cloning, Molecular; Culicidae / genetics; Culicidae / physiology; Evolution, Molecular; Female; Insect Proteins / genetics; Insect Proteins / metabolism; Life Cycle Stages; Male; Phylogeny; Protein Isoforms / genetics; Protein Isoforms / metabolism; Sequence Alignment; Sequence Analysis, DNA
Source: ORCID
Added: September 12, 2019

2012 journal article

Long identical multispecies elements in plant and animal genomes

Proceedings of the National Academy of Sciences of the United States of America, 109(19).

By: J. Reneker*, E. Lyons*, G. Conant*, J. Pires*, M. Freeling*, C. Shyu*, D. Korkin*

author keywords: extreme conservation; repetitive elements
MeSH headings : Amino Acid Sequence; Animals; Arabidopsis / genetics; Base Sequence; Cell Nucleus / genetics; Chromosome Mapping; Chromosomes, Mammalian / genetics; Chromosomes, Plant / genetics; Conserved Sequence / genetics; Evolution, Molecular; Gene Regulatory Networks; Genome / genetics; Genome, Mitochondrial / genetics; Genome, Plant / genetics; Humans; Mice; Models, Genetic; Molecular Sequence Data; Rats; Species Specificity; Synteny
Source: ORCID
Added: September 12, 2019

2012 journal article

Metabolic and evolutionary costs of herbivory defense: Systems biology of glucosinolate synthesis

New Phytologist, 196(2), 596–605.

author keywords: adaptation; Arabidopsis thaliana; costly traits; flux balance analysis; metabolic network
MeSH headings : Amino Acids / metabolism; Arabidopsis / genetics; Arabidopsis / immunology; Arabidopsis / metabolism; Biological Evolution; Biomass; Biosynthetic Pathways / genetics; Gene Duplication; Gene Expression Regulation, Plant; Glucosinolates / biosynthesis; Herbivory / genetics; Metabolome / genetics; Models, Biological; Photons; Systems Biology
Source: ORCID
Added: September 12, 2019

2012 journal article

Polyploidy and the Evolution of Complex Traits

International Journal of Evolutionary Biology, 2012, 1–12.

By: L. Huminiecki* & G. Conant*

Sources: Crossref, ORCID
Added: November 17, 2019

2012 journal article

Very low rate of gene conversion in the yeast genome

Molecular Biology and Evolution, 29(12), 3817–3826.

By: C. Casola*, G. Conant* & M. Hahn*

author keywords: gene duplication; Saccharomyces cerevisiae; interlocus gene conversion
MeSH headings : Base Sequence; Computational Biology; Evolution, Molecular; Gene Conversion / genetics; Gene Duplication / genetics; Genome, Fungal / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Phylogeny; Saccharomyces cerevisiae / genetics; Sequence Alignment; Species Specificity
Source: ORCID
Added: September 12, 2019

2012 book

Yeast as a window into changes in genome complexity due to polyploidization

In Polyploidy and Genome Evolution (Vol. 9783642314421, pp. 293–308).

By: C. Hudson* & G. Conant*

Source: ORCID
Added: September 12, 2019

2011 journal article

Copy number alterations among mammalian enzymes cluster in the metabolic network

Molecular Biology and Evolution, 28(2), 1111–1121.

By: M. Bekaert* & G. Conant*

author keywords: comparative genomic; gene duplication; gene dosage; mammals; metabolic networks and pathways; milk
MeSH headings : Animals; Cattle; Gene Dosage; Humans; Mammals / metabolism; Membrane Transport Proteins / genetics; Metabolic Networks and Pathways; Milk / metabolism
Source: ORCID
Added: September 12, 2019

2011 journal article

Expression level, cellular compartment and metabolic network position all influence the average selective constraint on mammalian enzymes

BMC Evolutionary Biology, 11(1).

By: C. Hudson* & G. Conant*

MeSH headings : Animals; Enzymes / genetics; Enzymes / metabolism; Gene Expression; Humans; Mammals / genetics; Mammals / metabolism; Metabolic Networks and Pathways; Protein Transport; Selection, Genetic
Sources: ORCID, Crossref
Added: September 12, 2019

2011 journal article

Patterns of indirect protein interactions suggest a spatial organization to metabolism

Molecular BioSystems, 7(11), 3056–3064.

By: A. Pérez-Bercoff*, A. McLysaght* & G. Conant*

MeSH headings : Binding Sites; Escherichia coli / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / metabolism; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Humans; Mediator Complex / metabolism; Metabolic Networks and Pathways; Protein Interaction Maps; Proteins / chemistry; Proteins / metabolism; Species Specificity; Yeasts / metabolism
Source: ORCID
Added: September 12, 2019

2011 journal article

Selection for higher gene copy number after different types of plant gene duplications

Genome Biology and Evolution, 3(1), 1369–1380.

author keywords: dosage selection; genome duplication; gene duplication
MeSH headings : Arabidopsis / genetics; Evolution, Molecular; Gene Dosage; Gene Duplication; Genes, Plant; Ion Pumps / genetics; Multigene Family; Phylogeny; Plant Proteins / genetics; Plants / genetics; Sorghum / genetics
Source: ORCID
Added: September 12, 2019

2011 journal article

The genome of the mesopolyploid crop species Brassica rapa

Nature Genetics, 43(10), 1035–1039.

By: X. Wang, H. Wang, J. Wang, R. Sun, J. Wu, S. Liu, Y. Bai, J. Mun ...

MeSH headings : Arabidopsis / genetics; Brassica rapa / genetics; Chromosomes, Artificial, Bacterial / genetics; Chromosomes, Plant / genetics; Contig Mapping; Evolution, Molecular; Gene Duplication; Genes, Plant; Genome, Plant; Molecular Sequence Annotation; Molecular Sequence Data; Phylogeny; Polyploidy; Sequence Analysis, DNA
Sources: ORCID, Crossref
Added: September 12, 2019

2011 journal article

Transcriptional robustness and protein interactions are associated in yeast

BMC Systems Biology, 5.

By: M. Bekaert* & G. Conant*

author keywords: Aneuploidy Dosage balance; Epistasis; Protein-Protein Interactions; Saccharomyces cerevisiae
MeSH headings : Aneuploidy; Epistasis, Genetic; Fungal Proteins / chemistry; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Fungal; Models, Biological; Protein Interaction Mapping; RNA, Messenger / metabolism; Regression Analysis; Saccharomyces cerevisiae / metabolism; Systems Biology / methods; Transcription, Genetic
Source: ORCID
Added: September 12, 2019

2011 journal article

Two-phase resolution of polyploidy in the Arabidopsis metabolic network gives rise to relative and absolute dosage constraints

Plant Cell, 23(5), 1719–1728.

MeSH headings : Arabidopsis / genetics; Arabidopsis / metabolism; Computational Biology; Evolution, Molecular; Gene Dosage / genetics; Gene Duplication; Genome, Plant / genetics; Logistic Models; Models, Genetic; Multigene Family; Polyploidy
Source: ORCID
Added: September 12, 2019

2010 journal article

Nonrandom survival of gene conversions among yeast ribosomal proteins duplicated through genome doubling.

Genome Biology and Evolution, 2, 826–834. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952199263&partnerID=MN8TOARS

By: A. Evangelisti & G. Conant

Source: ORCID
Added: September 12, 2019

2010 journal article

Rapid reorganization of the transcriptional regulatory network after genome duplication in yeast

Proceedings of the Royal Society B: Biological Sciences, 277(1683), 869–876.

By: G. Conant*

author keywords: whole-genome duplication; network evolution; regulatory evolution
MeSH headings : Computational Biology; Evolution, Molecular; Gene Duplication; Gene Regulatory Networks / genetics; Gene Regulatory Networks / physiology; Genome, Fungal / genetics; Genome, Fungal / physiology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology
Source: ORCID
Added: September 12, 2019

2010 journal article

The T box regulatory element controlling expression of the class i lysyl-tRNA synthetase of Bacillus cereus strain 14579 is functional and can be partially induced by reduced charging of asparaginyl-tRNAAsn

BMC Microbiology, 10.

By: N. Foy*, B. Jester*, G. Conant* & K. Devine*

MeSH headings : Amino Acid Sequence; Bacillus cereus / chemistry; Bacillus cereus / enzymology; Bacillus cereus / genetics; Bacillus cereus / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Gene Expression Regulation, Enzymologic; Lysine-tRNA Ligase / chemistry; Lysine-tRNA Ligase / genetics; Lysine-tRNA Ligase / metabolism; Molecular Sequence Data; RNA, Transfer, Amino Acyl / metabolism; RNA, Transfer, Asn / metabolism; Regulatory Elements, Transcriptional; Sequence Alignment
Source: ORCID
Added: September 12, 2019

2009 journal article

Neutral evolution on mammalian protein surfaces

Trends in Genetics, 25(9), 377–381.

By: G. Conant*

MeSH headings : Amino Acid Substitution / genetics; Animals; Evolution, Molecular; Genetic Variation; Humans; Membrane Proteins / chemistry; Membrane Proteins / genetics; Models, Genetic; Mutation; Selection, Genetic
Source: ORCID
Added: September 12, 2019

2009 journal article

Resolving the evolution of extant and extinct ruminants with high-throughput phylogenomics

Proceedings of the National Academy of Sciences of the United States of America, 106(44), 18644–18649.

By: J. Decker, J. Pires, G. Conant*, S. McKay, M. Heaton*, K. Chen*, A. Cooper*, J. Vilkki* ...

author keywords: ancient DNA; Pecorans; domestication
MeSH headings : Animals; Biological Evolution; Breeding; Cattle; DNA / analysis; DNA / genetics; Extinction, Biological; Fossils; Genomics / methods; Genotype; Phylogeny; Ruminants / genetics
Source: ORCID
Added: September 12, 2019

2009 journal article

Solvent exposure imparts similar selective pressures across a range of yeast proteins

Molecular Biology and Evolution, 26(5), 1155–1161.

By: G. Conant* & P. Stadler*

author keywords: amino acid substitution; evolutionary models; protein structure
MeSH headings : Amino Acid Substitution / genetics; Amino Acids; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / genetics; Selection, Genetic; Solvents / chemistry; Structural Homology, Protein; Surface Properties
Source: ORCID
Added: September 12, 2019

2008 journal article

Altered patterns of gene duplication and differential gene gain and loss in fungal pathogens

BMC GENOMICS, 9.

By: A. Powell*, G. Conant*, D. Brown n, I. Carbone n & R. Dean n

MeSH headings : Computational Biology; Evolution, Molecular; Fungi / genetics; Fungi / pathogenicity; Gene Duplication; Genomics; Multigene Family / genetics; Sequence Homology
Sources: ORCID, Web Of Science
Added: August 6, 2018

2008 journal article

GenomeVx: Simple web-based creation of editable circular chromosome maps

Bioinformatics, 24(6), 861–862.

By: G. Conant* & K. Wolfe*

MeSH headings : Chromosome Mapping / methods; Computer Graphics; Documentation / methods; Internet; Software; User-Computer Interface; Word Processing / methods
Source: ORCID
Added: September 12, 2019

2008 journal article

Increased glycolytic flux as an outcome of whole-genome duplication in yeast (Molecular Systems Biology (2007) 3 (129) DOI: 10.1038/msb4100170)

Molecular Systems Biology, 4.

By: G. Conant* & K. Wolfe

Source: ORCID
Added: September 12, 2019

2008 journal article

Probabilistic cross-species inference of orthologous genomic regions created by whole-genome duplication in yeast

Genetics, 179(3), 1681–1692.

By: G. Conant* & K. Wolfe*

MeSH headings : Candida glabrata / genetics; Gene Duplication; Genes, Fungal; Genome, Fungal / genetics; Models, Genetic; Phylogeny; Saccharomyces cerevisiae / genetics; Sequence Homology, Nucleic Acid; Species Specificity; Time Factors; Yeasts / genetics
Source: ORCID
Added: September 12, 2019

2008 journal article

Turning a hobby into a job: How duplicated genes find new functions

Nature Reviews Genetics, 9(12), 938–950.

By: G. Conant* & K. Wolfe*

MeSH headings : Animals; Galactokinase / genetics; Gene Dosage; Gene Duplication; Gene Expression; Genome; Humans; Mutation; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae Proteins / genetics; Selection, Genetic; Transcription Factors / genetics
Source: ORCID
Added: September 12, 2019

2007 journal article

Increased glycolytic flux as an outcome of whole‐genome duplication in yeast

Molecular Systems Biology, 3(1), 129.

By: G. Conant* & K. Wolfe*

author keywords: evolution; genome duplication; metabolism
MeSH headings : Cell Compartmentation; Ecology; Fermentation; Gene Duplication; Genes, Duplicate; Genes, Fungal; Genome, Fungal / genetics; Glycolysis / genetics; Models, Biological; Monosaccharide Transport Proteins / genetics; Respiration / genetics; Saccharomyces cerevisiae / enzymology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Selection, Genetic
Sources: ORCID, Crossref
Added: September 12, 2019

2007 journal article

Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication

Proceedings of the National Academy of Sciences of the United States of America, 104(20), 8397–8402.

By: D. Scannell*, A. Frank*, G. Conant*, K. Byrne*, M. Woolfit* & K. Wolfe*

author keywords: genomics; polyploidy; reciprocal gene loss; Vanderwaltozyma polyspora
MeSH headings : Base Sequence; Conserved Sequence; Evolution, Molecular; Gene Duplication; Gene Order; Genes, Duplicate; Genome, Fungal / genetics; Kluyveromyces / genetics; Likelihood Functions; Models, Genetic; Molecular Sequence Data; Saccharomyces cerevisiae / genetics; Sequence Homology, Nucleic Acid; Time Factors
Source: ORCID
Added: September 12, 2019

2007 journal article

Modeling amino acid substitution patterns in orthologous and paralogous genes

Molecular Phylogenetics and Evolution, 42(2), 298–307.

By: G. Conant*, G. Wagner & P. Stadler

author keywords: amino acid substitution; evolutionary models; protein evolution
MeSH headings : Actins / genetics; Amino Acid Substitution / genetics; Amino Acids / chemistry; Amino Acids / genetics; Animals; Databases, Nucleic Acid; Evolution, Molecular; Hemoglobins / genetics; Humans; Hydrophobic and Hydrophilic Interactions; Isoelectric Point; Models, Genetic; Myosins / genetics; Phylogeny; Rhodopsin / genetics; Rod Opsins / genetics
Source: ORCID
Added: September 12, 2019

2006 journal article

Functional Partitioning of Yeast Co-Expression Networks after Genome Duplication

PLoS Biology, 4(4), e109.

By: G. Conant* & K. Wolfe*

Ed(s): L. Hurst

MeSH headings : Base Sequence; Biological Evolution; Databases, Genetic; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Duplication; Gene Expression Regulation, Fungal / genetics; Genome, Fungal / genetics; Models, Biological; Phenotype; Protein Binding; Yeasts / genetics; Yeasts / metabolism
Sources: ORCID, Crossref
Added: September 12, 2019

2005 journal article

The rarity of gene shuffling in conserved genes.

Genome Biology, 6(6). http://www.scopus.com/inward/record.url?eid=2-s2.0-33646556197&partnerID=MN8TOARS

By: G. Conant & A. Wagner

Source: ORCID
Added: September 12, 2019

2004 journal article

A fast algorithm for determining the best combination of local alignments to a query sequence

BMC Bioinformatics, 5.

By: G. Conant* & A. Wagner*

MeSH headings : Algorithms; Animals; Caenorhabditis elegans / genetics; Computational Biology / methods; Computational Biology / statistics & numerical data; Computer Graphics / statistics & numerical data; DNA, Helminth / genetics; DNA, Mitochondrial / genetics; Drosophila melanogaster / genetics; Genome; Genome, Human; Hagfishes / genetics; Humans; Mitochondria / genetics; Sequence Alignment / methods; Sequence Alignment / statistics & numerical data
Source: ORCID
Added: September 12, 2019

2004 book

A second-generation genome screen for linkage to type 1 diabetes in a Bedouin Arab family

In Annals of the New York Academy of Sciences (Vol. 1037, pp. 157–160).

By: S. Babu*, G. Conant*, E. Eller*, C. Roberts*, K. Gowan*, G. Eisenbarth*, P. Fain*, P. Vardi*

author keywords: IDDM17; genome screen; genehunter; type 1 diabetes
MeSH headings : Arabs / genetics; Chromosomes, Human, Pair 10; Diabetes Mellitus, Type 1 / genetics; Female; Genetic Linkage; Genetic Markers; Genetic Predisposition to Disease; Genetic Testing; Genome, Human; Humans; Lod Score; Male; Statistics, Nonparametric
Source: ORCID
Added: September 12, 2019

2004 journal article

Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans

Proceedings of the Royal Society of London. Series B: Biological Sciences, 271(1534), 89–96.

By: G. Conant* & A. Wagner*

author keywords: Caenorhabditis elegans; gene duplication; mutational robustness
MeSH headings : Animals; Caenorhabditis elegans / genetics; Databases, Genetic; Evolution, Molecular; Genes, Duplicate / genetics; Multigene Family; Mutation / genetics; Oligonucleotide Array Sequence Analysis; Phenotype; RNA Interference
Sources: ORCID, Crossref
Added: September 12, 2019

2004 journal article

Molecular Evolution in Large Genetic Networks: Does Connectivity Equal Constraint?

Journal of Molecular Evolution, 58(2), 203–211.

By: M. Hahn*, G. Conant* & A. Wagner*

author keywords: power-law; mutational robustness; selective constraint; genetic network
MeSH headings : Energy Metabolism / genetics; Escherichia coli; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Evolution, Molecular; Likelihood Functions; Point Mutation / genetics; Protein Interaction Mapping; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Selection, Genetic; Two-Hybrid System Techniques
Source: ORCID
Added: September 12, 2019

2003 journal article

Asymmetric sequence divergence of duplicate genes

Genome Research, 13(9), 2052–2058.

By: G. Conant* & A. Wagner

MeSH headings : Amino Acid Substitution / genetics; Animals; Caenorhabditis elegans / genetics; Computational Biology / methods; Computational Biology / statistics & numerical data; Drosophila melanogaster / genetics; Evolution, Molecular; Gene Expression Profiling / methods; Gene Expression Profiling / statistics & numerical data; Gene Expression Regulation / genetics; Gene Expression Regulation, Fungal / genetics; Genes, Duplicate; Genetic Variation / genetics; Saccharomyces cerevisiae / genetics; Schizosaccharomyces / genetics
Source: ORCID
Added: September 12, 2019

2003 journal article

Convergent evolution of gene circuits

Nature Genetics, 34(3), 264–266.

By: G. Conant* & A. Wagner*

MeSH headings : Escherichia coli / genetics; Evolution, Molecular; Feedback / physiology; Gene Duplication; Gene Expression Regulation / genetics; Genes, Bacterial / physiology; Genes, Fungal / physiology; Genome, Bacterial; Genome, Fungal; Models, Genetic; Saccharomyces cerevisiae / genetics; Schizosaccharomyces / genetics; Transcription, Genetic / genetics
Source: ORCID
Added: September 12, 2019

2003 journal article

Parallel genehunter: Implementation of linkage analysis package for distributed-memory architectures

Journal of Parallel and Distributed Computing, 63(7-8), 674–682.

By: G. Conant*, S. Plimpton*, W. Old*, A. Wagner*, P. Fain, T. Pacheco, G. Heffelfinger*

Source: ORCID
Added: September 12, 2019

2002 journal article

GenomeHistory: A software tool and its application to fully sequenced genomes

Nucleic Acids Research, 30(15), 3378–3386. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036682357&partnerID=MN8TOARS

By: G. Conant & A. Wagner

Source: ORCID
Added: September 12, 2019

2002 conference paper

Parallel genehunter: Implementation of a linkage analysis package for distributed-memory architectures

Proceedings - International Parallel and Distributed Processing Symposium, IPDPS 2002, 184–191.

By: G. Conant*, S. Plimpton*, W. Old, A. Wagner*, P. Fain & G. Heffelfinger*

Source: ORCID
Added: September 12, 2019

2001 journal article

Effects of nucleotide composition bias on the success of the parsimony criterion in phylogenetic inference

Molecular Biology and Evolution, 18(6), 1024–1033. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034983477&partnerID=MN8TOARS

By: G. Conant & P. Lewis

Source: ORCID
Added: September 12, 2019