Works (74)
Updated: July 5th, 2023 16:02
2013 journal article
Early Weaning Stress in Pigs Impairs Innate Mucosal Immune Responses to Enterotoxigenic E. coli Challenge and Exacerbates Intestinal Injury and Clinical Disease
PLOS ONE, 8(4).
MeSH headings : Animals; Animals, Newborn; Cytokines / immunology; Cytokines / metabolism; Dextrans / metabolism; Enterotoxigenic Escherichia coli / immunology; Enterotoxigenic Escherichia coli / pathogenicity; Escherichia coli Infections / veterinary; Ileum / immunology; Ileum / metabolism; Ileum / microbiology; Ileum / pathology; Immunity, Innate; Immunity, Mucosal; Inflammation Mediators / immunology; Inflammation Mediators / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Mast Cells / immunology; Mast Cells / pathology; Neutrophils / immunology; Neutrophils / pathology; Permeability; Stress, Physiological / immunology; Swine; Swine Diseases / immunology; Weaning
TL;DR:
The early weaning stress can profoundly alter subsequent immune and physiology responses and clinical outcomes to subsequent infectious pathogen challenge, as demonstrated in pigs weaned from their dam.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
The Effects of Weak Genetic Perturbations on the Transcriptome of the Wing Imaginal Disc and Its Association With Wing Shape in Drosophila melanogaster
GENETICS, 187(4), 1171–U314.
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Insect; Genetic Variation; Genome, Insect; Genotype; Heterozygote; Linear Models; Multigene Family; Mutation; Phenotype; Transcriptional Activation; Wings, Animal / growth & development
TL;DR:
Weak mutational perturbations in genes affecting wing development in Drosophila melanogaster that influence wing shape relative to a co-isogenic wild type are used to examine overall patterns of covariation between phenotypic variables of interest and underlying aspects of gene activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Geographical genomics of human leukocyte gene expression variation in southern Morocco
NATURE GENETICS, 42(1), 62–U79.
MeSH headings : Arabs / genetics; Gene Expression Profiling / methods; Genetic Predisposition to Disease; Genetic Variation; Genetics, Population; Genome-Wide Association Study; Genomics / methods; Geography; Humans; Leukocytes / metabolism; Morocco; Polymorphism, Single Nucleotide; Principal Component Analysis
TL;DR:
No evidence of large-effect trans-acting mediators of the pervasive environmental influence was found; instead, genetic and environmental factors acted in a largely additive manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 review
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
[Review of ]. Human Molecular Genetics, 18(23), 4650–4661.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Association of orthodenticle with Natural Variation for Early Embryonic Patterning in Drosophila melanogaster
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, 312B(8), 841–854.
MeSH headings : Animals; Animals, Genetically Modified; Base Sequence; Body Patterning; DNA Primers; Drosophila Proteins / genetics; Drosophila melanogaster / embryology; Drosophila melanogaster / genetics; Enhancer Elements, Genetic; Female; Gene Expression; Haplotypes; Homeodomain Proteins / genetics; In Situ Hybridization; Molecular Sequence Data; Polymorphism, Genetic; Sequence Homology, Nucleic Acid
TL;DR:
It is demonstrated that even a process as robust as early developmental patterning is affected by standing genetic variation, intriguingly involving otd, whose morphogenetic function bicoid is thought to have displaced during dipteran evolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Genomic Consequences of Background Effects on scalloped Mutant Expressivity in the Wing of Drosophila melanogaster
GENETICS, 181(3), 1065–1076.
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / cytology; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Epistasis, Genetic; Gene Expression Regulation; Genetic Linkage; Genetic Variation; Genome, Insect / genetics; Genomics; Molecular Sequence Data; Mutation; Nuclear Proteins / genetics; Oligonucleotide Array Sequence Analysis; Transcription Factors / genetics; Transcription, Genetic; Wings, Animal / metabolism
TL;DR:
This study demonstrates that phenotypic expressivity of the scallopedE3 (sdE3) mutation of Drosophila melanogaster is background dependent and is the result of at least one major modifier segregating between two standard lab wild-type strains and demonstrates that the epistatic interaction between sdE3 and an optomotor blind mutation is backgrounddependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 book
It takes a genome: How a clash between our genes and modern life is making us sick
Upper Saddle River, N.J. : Pearson Education.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Pharmacogenetic association study of 30 genes with phenobarbital drug response in epileptic dogs
Pharmacogenetics and Genomics, 19(12), 911–922.
Contributors: E. Kennerly*, Y. Idaghdour*, N. Olby n , K. Munana n & *
author keywords: canine epilepsy; drug response; epoxide hydrolase; GABRA2; KCNQ3; pharmacogenetics; phenobarbital; SCN2A2
MeSH headings : Animals; Anticonvulsants / metabolism; Anticonvulsants / therapeutic use; Case-Control Studies; Dog Diseases / drug therapy; Dogs; Drug Resistance; Epilepsy / drug therapy; Epilepsy / veterinary; Pharmacogenetics; Phenobarbital / metabolism; Phenobarbital / therapeutic use; Polymorphism, Single Nucleotide
TL;DR:
Further replication and assessment of breed specificity is required before these markers can be considered as predictive of responsiveness to phenobarbital in dogs, but on functional grounds may tag strong candidate genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2008 journal article
A gene expression signature of confinement in peripheral blood of red wolves (Canis rufus)
MOLECULAR ECOLOGY, 17(11), 2782–2791.
author keywords: conservation genetics; heterologous microarray; Illumina; pro-inflammatory response
MeSH headings : Animals; Biomarkers / blood; Coyotes / genetics; Female; Gene Expression Profiling; Male; Models, Genetic; North Carolina; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Stress, Physiological / genetics; Wolves / genetics
TL;DR:
Characterization of differential transcript abundance in an accessible tissue such as peripheral blood identifies biomarkers that could be useful in animal management practices and for evaluating the impact of habitat changes on population health, particularly as attention turns to the effect of climate change on physiology and in turn species distributions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
13. Climate Action
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan amazighs
PLoS Genetics, 4(4).
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Failure to replicate effect of Kibra on human memory in two large cohorts of European origin
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B(5), 667–668.
author keywords: neurocognition; phenotype; cognitive task; replication; neurogenetics
MeSH headings : Cohort Studies; Europe; Humans; Intracellular Signaling Peptides and Proteins; Memory / physiology; Phosphoproteins; Polymorphism, Single Nucleotide; Proteins / genetics; Proteins / physiology; Reproducibility of Results; White People
TL;DR:
It is suggested that Kibra does not have a strong and general effect on human memory.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 review
Evolution of genes and genomes on the Drosophila phylogeny
[Review of ]. Nature, 450(7167), 203–218.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Human evolution: Thrifty genes and the dairy queen
Current Biology, 17(8), R295–296.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Human genetics: The hidden text of genome-wide associations
Current Biology, 17(21), R929–932.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Impact of population structure on genetic diversity of a potential vaccine target in the canine hookworm (Ancylostoma caninum)
JOURNAL OF PARASITOLOGY, 93(4), 796–805.
MeSH headings : Ancylostoma / genetics; Ancylostoma / growth & development; Ancylostoma / immunology; Ancylostomiasis / parasitology; Ancylostomiasis / veterinary; Animals; DNA, Helminth / chemistry; Dog Diseases / parasitology; Dogs; Electron Transport Complex IV / genetics; Electron Transport Complex IV / immunology; Female; Genetic Variation; Haplotypes; Helminth Proteins / genetics; Helminth Proteins / immunology; Male; Maryland; North Carolina; Population Dynamics; Queensland; Vaccines / genetics; Vaccines / immunology
TL;DR:
Test whether positive selection, population structure, or both affect genetic variation at the candidate vaccine target Ancylostoma secreted protein 1 (asp-1), using the statistical population analysis tools found in the SNAP Workbench.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Mixture modeling of transcript abundance classes in natural populations
GENOME BIOLOGY, 8(6).
MeSH headings : Animals; California; Cell Line, Tumor; Drosophila melanogaster / genetics; Female; Gene Expression Profiling; Genetics, Population; Humans; Male; North Carolina; Transcription, Genetic
TL;DR:
Population surveys of gene expression may complement genetical genomics as a general approach to quantifying sources of transcriptional variation by exploring the distributions of cis-acting and trans-acting factors and their relative contributions to expression of transcripts that exhibit two or more classes of abundance within populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster
NATURE GENETICS, 39(2), 264–268.
MeSH headings : Animals; California; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Drug Resistance; Female; Genetic Linkage; Genetic Variation; Glutamate Decarboxylase / metabolism; Isoenzymes / metabolism; Longevity; Mice; Nicotine / pharmacology; North Carolina; Ornithine-Oxo-Acid Transaminase / metabolism; Quantitative Trait Loci; gamma-Aminobutyric Acid / metabolism
TL;DR:
A complex role for ornithine and GABA levels in modification of survival time upon chronic nicotine exposure is confirmed and differences between populations from North Carolina and California suggest that the resistance mechanism may be an evolved response to environmental exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes
BMC SYSTEMS BIOLOGY, 1.
MeSH headings : Acetaminophen / toxicity; Algorithms; Animals; Clinical Chemistry Tests / statistics & numerical data; Cluster Analysis; Data Interpretation, Statistical; Disease Models, Animal; Gene Expression Profiling / statistics & numerical data; Heart Diseases / blood; Heart Diseases / genetics; Heart Diseases / pathology; Humans; Liver / drug effects; Liver / pathology; Necrosis; Phenotype; Rats
TL;DR:
Following modk-prototypes clustering of the acetaminophen-exposed samples, informative genes from the cluster prototypes were identified that are descriptive of, and phenotypically anchored to, levels of necrosis of the centrilobular region of the rat liver.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 review
Analysis of variance of microarray data
[Review of ]. Dna microarrays, part b: databases and statistics, 411, 214-. San Diego: Elsevier Academic Press Inc.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster
GENETICS, 173(3), 1417–1431.
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; ErbB Receptors / genetics; ErbB Receptors / metabolism; Genetic Variation; Genotype; Morphogenesis; Mutation; Signal Transduction / genetics; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Wings, Animal / anatomy & histology
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Evolution: The plastic transcriptorne
Current Biology, 16(8), R285–287.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Gene expression profiles associated with the transition to parasitism in Ancylostoma caninum larvae
Molecular and Biochemical Parasitology, 143(1), 39–48.
Source: NC State University Libraries
Added: August 6, 2018
2005 article
Genetic variation for dorsal-ventral patterning of the Drosophila melanogaster eggshell
EVOLUTION & DEVELOPMENT, Vol. 7, pp. 81–88.
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Drosophila Proteins / genetics; Drosophila melanogaster; ErbB Receptors / genetics; Ovum / physiology; Polymorphism, Genetic; Signal Transduction / genetics; Signal Transduction / physiology
TL;DR:
It is concluded that the polymorphisms identified in Egfr do not contribute to variation in DAS, and further work is required to understand the genetic architecture of this trait.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Microarray analysis of differentially expressed genes of primary tumors in the canine central nervous system
VETERINARY PATHOLOGY, 42(5), 550–558.
author keywords: cDNA microarray; canine choroid plexus tumor; ependymoma; glial tumor; meningioma
MeSH headings : Animals; Astrocytoma / genetics; Astrocytoma / veterinary; Brain Neoplasms / genetics; Brain Neoplasms / veterinary; Dog Diseases / genetics; Dogs; Ependymoma / genetics; Ependymoma / veterinary; Female; Gene Expression Regulation, Neoplastic / genetics; Glioblastoma / genetics; Glioblastoma / veterinary; Male; Meningeal Neoplasms / genetics; Meningeal Neoplasms / veterinary; Meningioma / genetics; Meningioma / veterinary; Oligodendroglioma / genetics; Oligodendroglioma / veterinary; Oligonucleotide Array Sequence Analysis / veterinary; Papilloma / genetics; Papilloma / veterinary
TL;DR:
This report represents the first global gene expression analysis of different types of canine brain tumors by cDNA microarrays and might aid in the identification of potential candidate genes involved in tumor formation and progression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Mutation accumulation of the transcriptome
Nature Genetics, 37(5), 458–460.
Source: NC State University Libraries
Added: August 6, 2018
2005 article
Q & A - Greg Gibson
Gibson, G. (2005, July 26). Q & A - Greg Gibson. CURRENT BIOLOGY, Vol. 15, pp. R531–R532.
MeSH headings : Biological Evolution; Career Choice; Genetics / education; Genetics / trends; Genomics / trends
TL;DR:
Greg Gibson grew up in Canberra, Australia, and moved to Basel, Switzerland, for his PhD on the specificity of homeotic genes in Drosophila, and then to Stanford for postdoctoral research, where his interests turned to the quantitative genetics of development in flies.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Replication of an egfr-wing shape association in a wild-caught cohort of Drosaphila melanogaster
GENETICS, 169(4), 2115–2125.
MeSH headings : Alleles; Analysis of Variance; Animals; Chromosome Mapping; Cohort Studies; Drosophila melanogaster / metabolism; ErbB Receptors / metabolism; ErbB Receptors / physiology; Evolution, Molecular; Gene Frequency; Genotype; Linkage Disequilibrium; Models, Genetic; Phenotype; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Wings, Animal / anatomy & histology; Wings, Animal / embryology
TL;DR:
It is demonstrated that despite considerable phenotypic differences for wing shape between a lab-reared experimental population and a wild-caught cohort of Drosophila melanogaster, an association between a putative regulatory polymorphism in Egfr and wing shape can be replicated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 review
Robustness and evolvability in living systems
[Review of ]. Science, 310(5746), 237.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology
BMC Genetics, 6.
Source: NC State University Libraries
Added: August 6, 2018
2005 review
The quantitative genetics of transcription
[Review of ]. TRENDS IN GENETICS, 21(11), 616–623.
MeSH headings : Chi-Square Distribution; Chromosome Mapping; Evolution, Molecular; Genetic Variation; Humans; Quantitative Trait Loci; Transcription, Genetic
TL;DR:
Several studies imply pervasive non-additivity of transcription, transgressive segregation and epistasis, and future studies will soon document the extent of genotype-environment interaction and population structure at the transcriptional level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 article
The synthesis and evolution of a supermodel
Gibson, G. (2005, March 25). SCIENCE, Vol. 307, pp. 1890–1891.
MeSH headings : Alleles; Animals; Animals, Genetically Modified; Biological Evolution; Chromosome Mapping; Chromosome Walking; Crosses, Genetic; Ectodysplasins; Fresh Water; Gene Frequency; Genetic Variation; Haplotypes; Membrane Proteins / genetics; Mutation; Seawater; Selection, Genetic; Smegmamorpha / anatomy & histology; Smegmamorpha / genetics; Smegmamorpha / growth & development
TL;DR:
In his Perspective, Gibson discusses the discovery that repeated selection of Eda alleles (encoding the protein ectodysplasin) resulted in the parallel evolution of the low-armor stickleback forms in most freshwater locations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 book
A primer of genome science (2nd ed.)
Sunderland, MA: Sinauer Associates.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Anomalies in the expression profile of interspecific hybrids of Drosophila melanogaster and Drosophila simulans
GENOME RESEARCH, 14(3), 373–379.
MeSH headings : Animals; Breeding / methods; Crosses, Genetic; DNA, Complementary / classification; DNA, Complementary / genetics; Drosophila / embryology; Drosophila / genetics; Drosophila melanogaster / embryology; Drosophila melanogaster / genetics; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / chemistry; Embryo, Nonmammalian / metabolism; Female; Gene Expression Profiling / methods; Gene Expression Regulation, Developmental / genetics; Genes, Insect / genetics; Genes, Lethal / genetics; Hybridization, Genetic / genetics; Male; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis / methods; Sex Factors
TL;DR:
The net result of the multiple incompatibilities is that the gene-expression profiles of the parental females are more similar to each other than either is to that of the hybrid.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Association between nudeotide variation in Egfr and wing shape in Drosophild melanogaster
GENETICS, 167(3), 1187–1198.
MeSH headings : Analysis of Variance; Animals; Base Sequence; Biometry; Body Weights and Measures; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; ErbB Receptors / genetics; Genetic Variation; Genotype; Molecular Sequence Data; North Carolina; Polymorphism, Genetic; Protein Kinases / genetics; Quantitative Trait Loci; Receptors, Invertebrate Peptide / genetics; Sequence Alignment; Wings, Animal / anatomy & histology
TL;DR:
Whole-gene sequencing in very large samples, rather than selective genotyping, would appear to be the only strategy likely to be successful for detecting subtle associations in species with high polymorphism and little haplotypes, but features severely limit the ability of linkage disequilibrium mapping in Drosophila to resolve quantitative effects to single nucleotides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Cross-species comparison of genome-wide expression patterns
Genome Biology, 5(7).
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Effects of population structure and sex on association between serotonin receptors and Drosophila heart rate
GENETICS, 168(4), 1963–1974.
MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Female; Genetic Variation; Genetics, Population; Heart / physiology; Heart Rate / genetics; Heart Rate / physiology; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide; Pupa / genetics; Pupa / physiology; Receptors, Serotonin, 5-HT1 / genetics; Receptors, Serotonin, 5-HT1 / metabolism
TL;DR:
While it is likely that a combination of weak, complex selection pressures and population structure has helped shape variation in the serotonin receptors of Drosophila, much larger sampling strategies than are currently adopted in evolutionary genetics will be required to disentangle these effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Extensive sex-specific nonadditivity of gene expression in Drosophila melanogaster
GENETICS, 167(4), 1791–1799.
MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Gene Expression Regulation / physiology; Genotype; Male; Models, Genetic; Models, Statistical; Oligonucleotide Array Sequence Analysis; Phylogeny; Sex Characteristics; Transcription, Genetic / physiology
TL;DR:
Comparison of adults of two isogenic lines and their reciprocal F1 hybrids revealed 5820 genes as significantly different between at least two of the four genotypes in either males or females or across both sexes, suggesting that heterosis for expression is rare.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Genes Regulated by Mating, Sperm, or Seminal Proteins in Mated Female Drosophila melanogaster
Current Biology, 14(16), 1509–1514.
MeSH headings : Animals; DNA Primers; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene Expression Regulation / physiology; Genes, Insect / genetics; Male; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Reverse Transcriptase Polymerase Chain Reaction; Seminal Plasma Proteins / metabolism; Seminal Plasma Proteins / physiology; Sexual Behavior, Animal / physiology; Spermatozoa / metabolism; Spermatozoa / physiology
TL;DR:
The mating-dependent genes that the authors have identified contribute to many biological processes including metabolism, immune defense, and protein modification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2004 journal article
Nucleotide variation in the Egfr locus of Drosophila melanogaster
GENETICS, 167(3), 1199–1212.
MeSH headings : Analysis of Variance; Animals; Base Sequence; California; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; ErbB Receptors / genetics; Gene Frequency; Genetic Variation; Genetics, Population; Haplotypes / genetics; Kenya; Linkage Disequilibrium; Molecular Sequence Data; North Carolina; Polymorphism, Genetic; Protein Kinases / genetics; Receptors, Invertebrate Peptide / genetics; Sequence Analysis, DNA
TL;DR:
Analysis of sequence diversity in 10.9 kb covering the complete coding region and 6.4 kb of potential regulatory regions in a sample of 250 alleles from three populations of Drosophila melanogaster suggests that the intensity of different population genetic forces varies along the locus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 review
Uncovering cryptic genetic variation
[Review of ]. NATURE REVIEWS GENETICS, 5(9), 681–U11.
MeSH headings : Animals; Drosophila melanogaster / genetics; Genetic Variation; Linkage Disequilibrium; Quantitative Trait, Heritable; Selection, Genetic
TL;DR:
It is argued that cryptic genetic variation is pervasive but under-appreciated, recent progress in determining the nature and identity of genes that underlie cryptic genetic effects is highlighted, and future research directions are outlined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Use of regression methods to identify motifs that modulate germline transcription in Drosophila melanogaster
GENETICS RESEARCH, 83(3), 177–188.
MeSH headings : Animals; Binding Sites / genetics; DNA / genetics; DNA / metabolism; Decision Trees; Drosophila melanogaster / genetics; Gene Expression Regulation / genetics; Linear Models; Models, Genetic; Regression Analysis; Regulatory Sequences, Nucleic Acid / genetics; Sex Factors; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
A regression tree model provides a grouping of independent variables into multiple linear models, an advantage over a single multivariate model, and suggests binding sites for cooperating factors in sex-specific expression, as well as a way of combining smaller motifs into larger binding sites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila
MOLECULAR ECOLOGY, 12(5), 1315–1323.
author keywords: Corkscrew; Drosophila melanogaster; Drk; Dsor1; HKA test; Ksr; nucleotide polymorphism; pole hole
MeSH headings : Animals; Base Sequence; DNA Primers; Drosophila / genetics; Drosophila / physiology; Drosophila Proteins / genetics; Genetic Variation; Genetics, Population; Molecular Sequence Data; Polymorphism, Single Nucleotide; Selection, Genetic; Signal Transduction
TL;DR:
It is inferred that contrasting selection pressures act on six components of the Ras signal transduction pathway by comparing sequences obtained from 25 alleles of Drosophila melanogaster with one allele of the sibling species D. simulans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster
CURRENT BIOLOGY, 13(21), 1888–1893.
MeSH headings : Alleles; Animals; California; Crosses, Genetic; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Epistasis, Genetic; Female; Genes, erbB-1 / genetics; Genetic Variation; Inbreeding; Linkage Disequilibrium; Male; Photoreceptor Cells, Invertebrate / anatomy & histology; Polymorphism, Single Nucleotide; Selection, Genetic; Sequence Analysis, DNA
TL;DR:
Replication of the strongest associations with an independent sample of 302 phenotypically extreme individuals derived from 1000 crosses of Egfr(E1) to freshly trapped males and a tendency for the rarer alleles to have more disrupted eye development suggests that mutation-selection balance is a possible mechanism contributing to maintaining cryptic variation for Egfr.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 article
Merging ecology, molecular evolution, and functional genetics
Purugganan, M., & Gibson, G. (2003, May). MOLECULAR ECOLOGY, Vol. 12, pp. 1109–1112.
MeSH headings : Ecology; Evolution, Molecular; Genotype; Phenotype
TL;DR:
While the use of molecular markers by ecologists has been fruitful, there is more to the molecules than their current dominant role in ecological research as mere genetic barcodes, and ecologists stand today at a crossroads that provide unprecedented opportunity to make connections between genes and ecological processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 article
Microarray analysis - Genome-scale hypothesis scanning
Gibson, G. (2003, October). PLOS BIOLOGY, Vol. 1, pp. 28–29.
MeSH headings : Animals; Base Sequence; Computational Biology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Gene Expression Profiling; Genetic Techniques; Genome; Genome, Human; Genomics; Humans; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis / methods; Research Design; Sequence Analysis, DNA
TL;DR:
Microarrays can survey genome-wide expression patterns and be used to identify a few genes of interest, now being creatively applied for hypothesis generation and testing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Mixed-model reanalysis of primate data suggests tissue and species biases in oligonucleotide-based gene expression profiles
Genetics, 165(2), 747–757.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Perspective: Evolution and detection of genetic robustness
EVOLUTION, 57(9), 1959–1972.
author keywords: canalization; environmental robustness; epistasis; evolvability; genetic robustness
TL;DR:
This work focuses on the first kind of robustness—genetic robustness)—and survey three growing avenues of research: measuring genetic robustness in nature and in the laboratory; understanding the evolution of genetic robusts; and exploring the implications of genetic resilientness for future evolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 article
Population genomics: Finding the dispatch variants of mass disruption
Gibson, G. (2003, December 2). CURRENT BIOLOGY, Vol. 13, pp. R901–R903.
MeSH headings : DNA-Binding Proteins / genetics; Evolution, Molecular; Gene Expression Regulation; Gene Frequency; Genetics, Population; Genome, Human; Geography; Humans; Interleukin-4 / genetics; Interleukin-4 / metabolism; Models, Genetic; NFATC Transcription Factors; Nuclear Proteins; Polymorphism, Single Nucleotide / genetics; Transcription Factors / genetics
TL;DR:
A study of positive selection on the promoter of the human interleukin-4 gene suggests that some disease-promoting alleles might be identified as polymorphic sites that affect transcription and occur at different frequencies among human populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 article
Population genomics: celebrating individual expression
Gibson, G. (2003, January). HEREDITY, Vol. 90, pp. 1–2.
MeSH headings : Biological Evolution; Expressed Sequence Tags; Genetic Variation; Genetics, Population; Genomics; Oligonucleotide Array Sequence Analysis
TL;DR:
Variation in transcript abundance is likely to be somewhat closer to phenotypic variation than are the actual genotypes, because transcript abundance already integrates developmental and environmental noise with regulatory polymorphisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
A genetic attack on the defense complex
BIOESSAYS, 24(6), 487–489.
MeSH headings : Animals; Chromosome Mapping; Fishes; Genetic Variation; Genome; Microsatellite Repeats / genetics; Quantitative Trait, Heritable
TL;DR:
A microsatellite-based map for threespine stickleback fish (Gasterosteus aculeatus) is provided, and the first evidence for QTL affecting feeding morphology and defensive armor is found.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 book
A primer of genome science
Sunderland, MA: Sinauer.
Source: NC State University Libraries
Added: August 6, 2018
2002 article
Developmental evolution: Getting robust about robustness
Gibson, G. (2002, May 14). CURRENT BIOLOGY, Vol. 12, pp. R347–R349.
MeSH headings : Animals; Biological Evolution; Cell Differentiation; Drosophila melanogaster / cytology; Drosophila melanogaster / embryology; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Homeostasis; Models, Neurological; Nerve Net / cytology; Nerve Net / embryology; Nerve Net / metabolism; Neurons / cytology; Neurons / metabolism; Proteins; Repressor Proteins / metabolism; Selection, Genetic
TL;DR:
This work has shown that a new mode of theoretical modeling of genetic networks holds great promise for increasing the understanding of both the quantitative mechanisms of robustness and its evolutionary impact.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 review
Enabling population and quantitative genomics
[Review of ]. GENETICS RESEARCH, 80(1), 1–6.
MeSH headings : Animals; Drosophila melanogaster / genetics; Genetics, Population; Genomics
TL;DR:
The set of community-wide genetic and molecular resources, including panels of specific types of inbred lines and high density resequencing and SNP detection, that will facilitate studies of quantitative traits to the nucleotide level are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Microarrays in ecology and evolution: A preview.
Molecular Ecology, 11(1), 17–24.
Source: NC State University Libraries
Added: August 6, 2018
2002 review
Microarrays in ecology and evolution: a preview
[Review of ]. MOLECULAR ECOLOGY, 11(1), 17–24.
author keywords: cDNA microarray; gene expression profiling; parasitism; population structure; quantitative genomics; symbiosis; variation
MeSH headings : Animals; Ecology; Evolution, Molecular; Female; Gene Expression Profiling / economics; Gene Expression Profiling / methods; Genetic Variation; Genetics, Population; Genotype; Geography; Humans; Male; Oligonucleotide Array Sequence Analysis / economics; Oligonucleotide Array Sequence Analysis / methods; Sex Factors
TL;DR:
Applications of microarray technology in relation to studies of mechanisms of adaptation and divergence; delineation of developmental and physiological pathways and networks; characterization of quantitative genetic parameters at the level of transcription (‘quantitative genomics’); molecular dissection of parasitism and symbiosis; and studies of the diversification of gene content are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
The evolution of developmental regulatory pathways
CURRENT OPINION IN GENETICS & DEVELOPMENT, 12(6), 695–700.
MeSH headings : Animals; Biological Evolution; Gene Expression Regulation, Developmental; Genes, Regulator; Humans; Phylogeny
TL;DR:
notation of the fission yeast, rice, and mouse genomes confirms that most regulatory families are shared among eukaryotes but also shows that certain gene families have restricted distributions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Unusual genetic architecture of natural variation affecting drug resistance in Drosophila melanogaster
GENETICAL RESEARCH, 80(3), 205–213.
MeSH headings : Analysis of Variance; Animals; Crosses, Genetic; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Female; Genetic Variation; Insecticide Resistance / genetics; Male
TL;DR:
Naturally occurring genetic variation was quantified for survival time of adult Drosophila melanogaster exposed to chronic ingestion of the drugs nicotine, caffeine, dopamine, tyramine and octopamine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Assessing gene significance from cDNA microarray expression data via mixed models
JOURNAL OF COMPUTATIONAL BIOLOGY, 8(6), 625–637.
Contributors: L. Bennett*
author keywords: ANOVA; cDNA microarray; gene expression; mixed models; statistical significance
MeSH headings : Computational Biology; Gene Expression Profiling / statistics & numerical data; Genes, Fungal; Humans; Lymphoma, B-Cell / genetics; Models, Genetic; Models, Statistical; Oligonucleotide Array Sequence Analysis / statistics & numerical data; Saccharomyces cerevisiae / genetics
TL;DR:
A statistical approach is presented that allows direct control over the percentage of false positives in such a list of differentially expressed genes and, under certain reasonable assumptions, improves on existing methods with respect to the percentages of false negatives.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2001 journal article
Developmental evolution: The unbearable likeness of beings
CURRENT BIOLOGY, 11(9), R345–R348.
MeSH headings : Animals; Biological Evolution; Genetic Variation; Nematoda / genetics
TL;DR:
Two new studies identify genetic variation within nematode species that affects cell division and competence in vulval precursors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Evolution: A complement for evolutionary genetics
CURRENT BIOLOGY, 11(2), R74–R76.
MeSH headings : Animals; Drosophila / genetics; Evolution, Molecular; Female; Male; Quantitative Trait, Heritable
TL;DR:
Recent studies highlight how complementation tests between species can bridge the gap between these approaches to comparative analysis of gene expression and quantitative genetics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Quantitative trait loci for the monoamine-related traits heart rate and headless behavior in Drosophila melanogaster
Genetics, 157(1), 283–294.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster
NATURE GENETICS, 29(4), 389–395.
MeSH headings : Aging / genetics; Aging / physiology; Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Genotype; Male; Sex Factors; Transcription, Genetic
TL;DR:
A statistically rigorous approach to quantifying microarray expression data that allows the relative effects of multiple classes of treatment to be compared and incorporates analytical methods that are common to quantitative genetics is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Canalization in evolutionary genetics: a stabilizing theory?
BioEssays, 22(4), 372–380.
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Evolution: Hox genes and the cellared wine principle
CURRENT BIOLOGY, 10(12), R452–R455.
MeSH headings : Animals; Drosophila / embryology; Drosophila / genetics; Drosophila Proteins; Evolution, Molecular; Fushi Tarazu Transcription Factors; Genes, Homeobox; Homeodomain Proteins / genetics; Trans-Activators / genetics
TL;DR:
Two Drosophila Hox genes involved in segmentation, fushi tarazu and bicoid, appear to have acquired these roles by functional divergence from classical homeotic genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Genetic variation for the positioning of wing veins in Drosophila melanogaster
EVOLUTION & DEVELOPMENT, 2(1), 16–24.
MeSH headings : Animals; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Genetic Variation; Wings, Animal / blood supply
TL;DR:
It is concluded that wing shape is under tighter genetic control than wing size, and hypothesize that this control is achieved in large part by gene activity at the level of wing vein determination and differentiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Haplotype dimorphism in a SNP collection from Drosophila melanogaster
JOURNAL OF EXPERIMENTAL ZOOLOGY, 288(1), 63–75.
TL;DR:
The possible mechanisms for and implications of the unexpected finding that two thirds of all short gene sequences in D. melanogaster may be dimorphic are discussed, including the suggestion that admixture between two separate lineages may have been a major event in the history of the species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Quantitative trait loci affecting components of wing shape in Drosophila melanogaster
Genetics, 155(2), 671–683.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Absence of protein polymorphism in the Ras genes of Drosophila melanogaster
JOURNAL OF MOLECULAR EVOLUTION, 49(5), 583–590.
author keywords: Drosophila melanogaster; Ras; Rap; HKA test; polymorphism; oncogene
MeSH headings : Alleles; Animals; Base Sequence; DNA / genetics; DNA Primers / genetics; Drosophila / genetics; Drosophila melanogaster / genetics; Evolution, Molecular; Genes, Insect; Genes, ras; Genetic Variation; Insect Proteins / genetics; Polymorphism, Genetic; Sequence Homology, Nucleic Acid; Species Specificity; ras Proteins / genetics
TL;DR:
Sequence analysis of 27 alleles of each of the three Ras-related genes in Drosophila melanogaster indicates that they all have low levels of polymorphism but may experience slightly different evolutionary pressures, and it is concluded that genetic variation in the Ras signal transduction pathways cannot be attributed to catalytic variation inThe Ras proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Axial variation in the threespine stickleback: genetic and environmental factors
EVOLUTION & DEVELOPMENT, 1(2), 100–112.
MeSH headings : Animals; Female; Fishes / anatomy & histology; Fishes / embryology; Fishes / genetics; Genetic Variation; Male; Phenotype; Skeleton; Sodium Chloride; Temperature
TL;DR:
It is demonstrated that considerable genetic variation for axial morphology is maintained in natural populations of threespine stickleback, and that differences between populations may be brought about rapidly by changes in frequency of alleles that have coordinated effects along the body axis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Developmental evolution: Going beyond the 'just so'
CURRENT BIOLOGY, 9(24), R942–R945.
MeSH headings : Animals; Baculoviridae / genetics; Biological Evolution; Embryonic Development; Gene Expression Regulation, Developmental; Genes, Homeobox; Genetic Vectors; Models, Genetic
TL;DR:
Two new protocols for infecting non-mammalian embryos with viruses and RNA inhibition have provided evolutionary developmental biologists with the tools to study the effects of manipulating gene activity in a wide range of species, allowing them to test hypotheses rather than rely on inference from similarity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Expression patterns of threespine stickleback Hox genes and insights into the evolution of the vertebrate body axis
Development Genes and Evolution, 209(8), 482–494.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Genetic variation affecting heart rate in Drosophila melanogaster
GENETICS RESEARCH, 74(2), 121–128.
MeSH headings : Animals; Crosses, Genetic; Data Interpretation, Statistical; Drosophila Proteins; Drosophila melanogaster / genetics; Ether-A-Go-Go Potassium Channels; Genetic Variation; Heart Rate / genetics; Humans; Potassium Channels / genetics; Pupa
TL;DR:
This study provides a baseline for investigation of pharmacological and other physiological influences on heart rate in the model organism, and implies that quantitative genetic dissection will provide insight into the molecular basis for variation in normal and arrhythmic heart function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Insect evolution: Redesigning the fruitfly
CURRENT BIOLOGY, 9(3), R86–R89.
MeSH headings : Animals; Antennapedia Homeodomain Protein; Bacterial Proteins; DNA-Binding Proteins / genetics; DNA-Binding Proteins / physiology; Drosophila Proteins; Drosophila melanogaster / embryology; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Drosophila melanogaster / ultrastructure; Evolution, Molecular; Genes; Genes, Homeobox; Genes, Insect; Homeodomain Proteins / genetics; Homeodomain Proteins / physiology; Morphogenesis / genetics; Nuclear Proteins; Transcription Factors; Wings, Animal / growth & development; Wings, Animal / ultrastructure
TL;DR:
Homeotic mutations in Drosophila can result in dramatic phenotypes that suggest the possibility for rapid morphological evolution, but dissection of the genetic pathway downstream of Ultrabithorax is beginning to reveal how wing morphology may have evolved by more gradual transformations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Potential variance affecting homeotic Ultrabithorax and Antennapedia phenotypes in Drosophila melanogaster
Genetics, 151(3), 1081–1091.
Source: NC State University Libraries
Added: August 6, 2018
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