Works (23)

2020 article

An artificial pathway for polyketide biosynthesis

Gayen, A. K., Nichols, L., & Williams, G. J. (2020, July). NATURE CATALYSIS, Vol. 3, pp. 536–538.

By: A. Gayen, L. Nichols & G. Williams

Source: Web Of Science
Added: August 3, 2020

2020 journal article

SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides

JOURNAL OF CHEMINFORMATICS, 12(1).

By: P. Zin, G. Williams & D. Fourches

Source: Web Of Science
Added: April 27, 2020

2019 journal article

An Artificial Pathway for Isoprenoid Biosynthesis Decoupled from Native Hemiterpene Metabolism

ACS SYNTHETIC BIOLOGY, 8(2), 232–238.

By: S. Lund, R. Hall & G. Williams

Source: Web Of Science
Added: March 11, 2019

2019 journal article

Development of a Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli

ACS SYNTHETIC BIOLOGY, 8(6), 1391–1400.

By: E. Kalkreuter, A. Keeler, A. Malico, K. Bingham, A. Gayen & G. Williams

Source: Web Of Science
Added: July 15, 2019

2019 journal article

Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(5), 1961–1969.

By: E. Kalkreuter, J. CroweTipton, A. Lowell, D. Sherman & G. Williams

Source: NC State University Libraries
Added: February 25, 2019

2019 article

Probing the Substrate Promiscuity of Isopentenyl Phosphate Kinase as a Platform for Hemiterpene Analogue Production

CHEMBIOCHEM.

By: S. Lund, T. Courtney & G. Williams

Source: Web Of Science
Added: August 12, 2019

2018 journal article

Cheminformatics-based enumeration and analysis of large libraries of macrolide scaffolds

JOURNAL OF CHEMINFORMATICS, 10.

By: P. Zin, G. Williams & D. Fourches

Source: NC State University Libraries
Added: December 3, 2018

2018 journal article

Direct analysis of terpenes from biological buffer systems using SESI and IR-MALDESI

Analytical and Bioanalytical Chemistry, 410(3), 953–962.

By: M. Nazari, A. Malico, M. Ekelof, S. Lund, G. Williams & D. Muddiman

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Engineering enzymatic assembly lines for the production of new antimicrobials

CURRENT OPINION IN MICROBIOLOGY, 45, 140–148.

By: E. Kalkreuter & G. Williams

Source: NC State University Libraries
Added: January 21, 2019

2018 journal article

Extender Unit Promiscuity and Orthogonal Protein Interactions of an Aminomalonyl-ACP Utilizing Trans-Acyltransferase from Zwittermicin Biosynthesis

ACS CHEMICAL BIOLOGY, 13(12), 3361–3373.

By: S. Carpenter & G. Williams

Source: NC State University Libraries
Added: January 14, 2019

2017 journal article

Polyketide bioderivatization using the promiscuous Acyltransferase KirCII

ACS Synthetic Biology, 6(3), 421–427.

By: E. Musiol-Kroll, F. Zubeil, T. Schafhauser, T. Hartner, A. Kulik, J. McArthur, I. Koryakina, W. Wohlleben ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Harnessing natural product assembly lines: Structure, promiscuity, and engineering

Journal of Industrial Microbiology & Biotechnology, 43(2-3), 371–387.

By: C. Ladner & G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Evaluating nonpolar surface area and liquid chromatography/mass spectrometry response: an application for site occupancy measurements for enzyme intermediates in polyketide biosynthesis

Rapid Communications in Mass Spectrometry, 28(23), 2511–2522.

By: S. Randall, I. Koryakina, G. Williams & D. Muddiman

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Intracellular light-activation of riboswitch activity

Chembiochem, 15(9), 1346–1351.

By: S. Walsh, L. Gardner, A. Deiters & G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Mapping a ketosynthase:acyl carrier protein binding interface via unnatural amino acid-mediated photo-cross-linking

Biochemistry, 53(48), 7494–7502.

By: Z. Ye & G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Reprogramming Acyl Carrier Protein Interactions of an Acyl-CoA Promiscuous trans-Acyltransferase

Chemistry & Biology, 21(5), 636–646.

By: Z. Ye, E. Musiol, T. Weber & G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Engineering polyketide synthases and nonribosomal peptide synthetases

Current Opinion in Structural Biology, 23(4), 603–612.

By: G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Poly specific trans-acyltransferase machinery revealed via engineered Acyl-CoA synthetases

ACS Chemical Biology, 8(1), 200–208.

By: I. Koryakina, J. McArthur, S. Randall, M. Draelos, E. Musiol, D. Muddiman, T. Weber, G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Promiscuity of a modular polyketide synthase towards natural and non-natural extender units

Organic & Biomolecular Chemistry, 11(27), 4449–4458.

By: I. Koryakina, J. McArthur, M. Draelos & G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

A high-throughput screen for directed evolution of aminocoumarin amide synthetases

Analytical Biochemistry, 419(1), 61–66.

By: N. Parajuli & G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

A high-throughput screen for directed evolution of the natural product sulfotransferase LipB

Journal of Biomolecular Screening, 16(8), 845–851.

By: I. Koryakina, J. Neville, K. Nonaka, S. Van Lanen & G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

A photocrosslinking assay for reporting protein interactions in polyketide and fatty acid synthases

Molecular BioSystems, 7(11), 3152–3156.

By: Z. Ye, M. Bair, H. Desai & G. Williams

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Mutant Malonyl-CoA Synthetases with altered specificity for polyketide synthase extender unit generation

Chembiochem, 12(15), 2289–2293.

By: I. Koryakina & G. Williams

Source: NC State University Libraries
Added: August 6, 2018