@article{kalkreuter_bingham_keeler_lowell_schmidt_sherman_williams_2021, title={Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase}, volume={12}, DOI={10.1038/s41467-021-22497-2}, number={1}, journal={Nature Communications}, publisher={Springer Science and Business Media LLC}, author={Kalkreuter, Edward and Bingham, Kyle S. and Keeler, Aaron M. and Lowell, Andrew N. and Schmidt, Jennifer J. and Sherman, David H. and Williams, Gavin J.}, year={2021}, month={Dec} } @article{gayen_nichols_williams_2020, title={An artificial pathway for polyketide biosynthesis}, volume={3}, ISBN={2520-1158}, ISSN={2520-1158}, url={http://dx.doi.org/10.1038/s41929-020-0483-4}, DOI={10.1038/s41929-020-0483-4}, number={7}, journal={Nature Catalysis}, publisher={Springer Science and Business Media LLC}, author={Gayen, Anuran K. and Nichols, Lindsay and Williams, Gavin J.}, year={2020}, month={Jul}, pages={536–538} } @article{zin_williams_ekins_2020, title={Cheminformatics Analysis and Modeling with MacrolactoneDB}, volume={10}, ISBN={2045-2322}, ISSN={2045-2322}, url={http://dx.doi.org/10.1038/s41598-020-63192-4}, DOI={10.1038/s41598-020-63192-4}, number={1}, journal={Scientific Reports}, publisher={Springer Science and Business Media LLC}, author={Zin, Phyo Phyo Kyaw and Williams, Gavin J. and Ekins, Sean}, year={2020}, month={Apr} } @article{kalkreuter_bingham_keeler_lowell_schmidt_sherman_williams_2020, title={Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase}, volume={4}, DOI={10.1101/2020.04.23.058214}, publisher={Cold Spring Harbor Laboratory}, author={Kalkreuter, Edward and Bingham, Kyle S and Keeler, Aaron M and Lowell, Andrew N and Schmidt, Jennifer J. and Sherman, David H and Williams, Gavin J}, year={2020}, month={Apr} } @article{zin_williams_fourches_2020, title={SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides}, volume={12}, ISBN={1758-2946}, ISSN={1758-2946}, url={http://dx.doi.org/10.1186/s13321-020-00427-6}, DOI={10.1186/s13321-020-00427-6}, number={1}, journal={Journal of Cheminformatics}, publisher={Springer Science and Business Media LLC}, author={Zin, Phyo Phyo Kyaw and Williams, Gavin and Fourches, Denis}, year={2020}, month={Apr} } @article{malico_nichols_williams_2020, title={Synthetic biology enabling access to designer polyketides}, volume={58}, ISBN={1879-0402}, ISSN={1367-5931}, url={http://dx.doi.org/10.1016/j.cbpa.2020.06.003}, DOI={10.1016/j.cbpa.2020.06.003}, journal={Current Opinion in Chemical Biology}, publisher={Elsevier BV}, author={Malico, Alexandra A. and Nichols, Lindsay and Williams, Gavin J.}, year={2020}, month={Oct}, pages={45–53} } @article{malico_calzini_gayen_williams_2020, title={Synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis of isoprenoids (September, 10.1007/s10295-020-02306-3, 2020)}, volume={11}, ISBN={1476-5535}, DOI={10.1007/s10295-020-02327-y}, journal={JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY}, publisher={Springer Science and Business Media LLC}, author={Malico, Alexandra A. and Calzini, Miles A. and Gayen, Anuran K. and Williams, Gavin J.}, year={2020} } @article{malico_calzini_gayen_williams_2020, title={Synthetic biology, combinatorial biosynthesis, and chemo‑enzymatic synthesis of isoprenoids}, volume={47}, ISBN={1476-5535}, ISSN={1367-5435 1476-5535}, url={http://dx.doi.org/10.1007/s10295-020-02306-3}, DOI={10.1007/s10295-020-02306-3}, number={9-10}, journal={Journal of Industrial Microbiology & Biotechnology}, publisher={Springer Science and Business Media LLC}, author={Malico, Alexandra A. and Calzini, Miles A. and Gayen, Anuran K. and Williams, Gavin J.}, year={2020}, month={Sep}, pages={675–702} } @article{lund_hall_williams_2019, title={An Artificial Pathway for Isoprenoid Biosynthesis Decoupled from Native Hemiterpene Metabolism}, volume={8}, ISBN={2161-5063}, ISSN={2161-5063 2161-5063}, url={http://dx.doi.org/10.1021/acssynbio.8b00383}, DOI={10.1021/acssynbio.8b00383}, number={2}, journal={ACS Synthetic Biology}, publisher={American Chemical Society (ACS)}, author={Lund, Sean and Hall, Rachael and Williams, Gavin J}, year={2019}, month={Jan}, pages={232–238} } @article{lund_courtney_williams_2019, title={Cover Feature: Probing the Substrate Promiscuity of Isopentenyl Phosphate Kinase as a Platform for Hemiterpene Analogue Production (ChemBioChem 17/2019)}, volume={8}, DOI={10.1002/cbic.201900494}, journal={ChemBioChem}, publisher={Wiley}, author={Lund, Sean and Courtney, Taylor and Williams, Gavin J.}, year={2019}, month={Sep} } @article{kalkreuter_keeler_malico_bingham_gayen_williams_2019, title={Development of a Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli}, volume={8}, ISBN={2161-5063}, ISSN={2161-5063 2161-5063}, url={http://dx.doi.org/10.1021/acssynbio.9b00078}, DOI={10.1021/acssynbio.9b00078}, number={6}, journal={ACS Synthetic Biology}, publisher={American Chemical Society (ACS)}, author={Kalkreuter, Edward and Keeler, Aaron M. and Malico, Alexandra A. and Bingham, Kyle S. and Gayen, Anuran K. and Williams, Gavin J.}, year={2019}, month={May}, pages={1391–1400} } @article{kalkreuter_crowetipton_lowell_sherman_williams_2019, title={Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units}, volume={141}, ISSN={0002-7863 1520-5126}, url={http://dx.doi.org/10.1021/jacs.8b10521}, DOI={10.1021/jacs.8b10521}, number={5}, journal={Journal of the American Chemical Society}, publisher={American Chemical Society (ACS)}, author={Kalkreuter, Edward and CroweTipton, Jared M. and Lowell, Andrew N. and Sherman, David H. and Williams, Gavin J.}, year={2019}, month={Jan}, pages={1961–1969} } @article{lund_courtney_williams_2019, title={Probing the Substrate Promiscuity of Isopentenyl Phosphate Kinase as a Platform for Hemiterpene Analogue Production}, volume={20}, ISBN={1439-7633}, ISSN={1439-4227 1439-7633}, url={http://dx.doi.org/10.1002/cbic.201900135}, DOI={10.1002/cbic.201900135}, number={17}, journal={ChemBioChem}, publisher={Wiley}, author={Lund, Sean and Courtney, Taylor and Williams, Gavin J.}, year={2019}, month={Jul}, pages={2217–2221} } @article{zin_williams_fourches_2018, title={Cheminformatics-based enumeration and analysis of large libraries of macrolide scaffolds}, volume={10}, ISSN={1758-2946}, url={http://dx.doi.org/10.1186/s13321-018-0307-6}, DOI={10.1186/s13321-018-0307-6}, number={1}, journal={Journal of Cheminformatics}, publisher={Springer Science and Business Media LLC}, author={Zin, Phyo Phyo Kyaw and Williams, Gavin and Fourches, Denis}, year={2018}, month={Nov} } @article{kasey_zerrad_li_cropp_williams_2018, title={Development of Transcription Factor-Based Designer Macrolide Biosensors for Metabolic Engineering and Synthetic Biology}, volume={7}, ISSN={2161-5063 2161-5063}, url={http://dx.doi.org/10.1021/ACSSYNBIO.7B00287}, DOI={10.1021/ACSSYNBIO.7B00287}, number={1}, journal={ACS Synthetic Biology}, publisher={American Chemical Society (ACS)}, author={Kasey, Christian M. and Zerrad, Mounir and Li, Yiwei and Cropp, T. Ashton and Williams, Gavin J.}, year={2018}, month={Jan}, pages={227–239} } @article{kalkreuter_williams_2018, title={Engineering enzymatic assembly lines for the production of new antimicrobials}, volume={45}, ISSN={1369-5274}, url={http://dx.doi.org/10.1016/j.mib.2018.04.005}, DOI={10.1016/j.mib.2018.04.005}, journal={Current Opinion in Microbiology}, publisher={Elsevier BV}, author={Kalkreuter, Edward and Williams, Gavin J}, year={2018}, month={Oct}, pages={140–148} } @article{carpenter_williams_2018, title={Extender Unit Promiscuity and Orthogonal Protein Interactions of an Aminomalonyl-ACP Utilizing Trans-Acyltransferase from Zwittermicin Biosynthesis}, volume={13}, ISSN={1554-8929 1554-8937}, url={http://dx.doi.org/10.1021/acschembio.8b00867}, DOI={10.1021/acschembio.8b00867}, number={12}, journal={ACS Chemical Biology}, publisher={American Chemical Society (ACS)}, author={Carpenter, Samantha M. and Williams, Gavin J.}, year={2018}, month={Nov}, pages={3361–3373} } @article{nazari_malico_ekelöf_lund_williams_muddiman_2017, title={Direct analysis of terpenes from biological buffer systems using SESI and IR-MALDESI}, volume={410}, ISSN={1618-2642 1618-2650}, url={http://dx.doi.org/10.1007/s00216-017-0570-9}, DOI={10.1007/s00216-017-0570-9}, number={3}, journal={Analytical and Bioanalytical Chemistry}, publisher={Springer Science and Business Media LLC}, author={Nazari, Milad and Malico, Alexandra A. and Ekelöf, Måns and Lund, Sean and Williams, Gavin J. and Muddiman, David C.}, year={2017}, month={Aug}, pages={953–962} } @article{koryakina_kasey_mcarthur_lowell_chemler_li_hansen_sherman_williams_2017, title={Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering}, volume={12}, ISSN={1554-8929 1554-8937}, url={http://dx.doi.org/10.1021/ACSCHEMBIO.6B00732}, DOI={10.1021/acschembio.6b00732}, number={1}, journal={ACS Chemical Biology}, publisher={American Chemical Society (ACS)}, author={Koryakina, Irina and Kasey, Christian and McArthur, John B. and Lowell, Andrew N. and Chemler, Joseph A. and Li, Shasha and Hansen, Douglas A. and Sherman, David H. and Williams, Gavin J.}, year={2017}, month={Jan}, pages={114–123} } @article{musiol-kroll_zubeil_schafhauser_härtner_kulik_mcarthur_koryakina_wohlleben_grond_williams_et al._2017, title={Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII}, volume={6}, ISSN={2161-5063 2161-5063}, url={http://dx.doi.org/10.1021/acssynbio.6b00341}, DOI={10.1021/acssynbio.6b00341}, number={3}, journal={ACS Synthetic Biology}, publisher={American Chemical Society (ACS)}, author={Musiol-Kroll, Ewa M. and Zubeil, Florian and Schafhauser, Thomas and Härtner, Thomas and Kulik, Andreas and McArthur, John and Koryakina, Irina and Wohlleben, Wolfgang and Grond, Stephanie and Williams, Gavin J. and et al.}, year={2017}, month={Feb}, pages={421–427} } @article{ladner_williams_2015, title={Harnessing natural product assembly lines: structure, promiscuity, and engineering}, volume={43}, ISSN={1367-5435 1476-5535}, url={http://dx.doi.org/10.1007/s10295-015-1704-8}, DOI={10.1007/s10295-015-1704-8}, number={2-3}, journal={Journal of Industrial Microbiology & Biotechnology}, publisher={Springer Science and Business Media LLC}, author={Ladner, Christopher C. and Williams, Gavin J.}, year={2015}, month={Nov}, pages={371–387} } @article{williams_2015, title={Harnessing the promiscuity of natural product biosynthesis: A platform for engineering pathways with new specificities}, volume={81}, ISSN={0032-0943 1439-0221}, url={http://dx.doi.org/10.1055/S-0035-1556155}, DOI={10.1055/S-0035-1556155}, number={11}, journal={Planta Medica}, publisher={Georg Thieme Verlag KG}, author={Williams, G}, year={2015}, month={Jun} } @article{randall_koryakina_williams_muddiman_2014, title={Evaluating nonpolar surface area and liquid chromatography/mass spectrometry response: an application for site occupancy measurements for enzyme intermediates in polyketide biosynthesis}, volume={28}, ISSN={0951-4198}, url={http://dx.doi.org/10.1002/rcm.7051}, DOI={10.1002/rcm.7051}, number={23}, journal={Rapid Communications in Mass Spectrometry}, publisher={Wiley}, author={Randall, Shan M. and Koryakina, Irina and Williams, Gavin J. and Muddiman, David C.}, year={2014}, month={Oct}, pages={2511–2522} } @article{walsh_gardner_deiters_williams_2014, title={Intracellular Light-Activation of Riboswitch Activity}, volume={15}, ISSN={1439-4227}, url={http://dx.doi.org/10.1002/cbic.201400024}, DOI={10.1002/cbic.201400024}, number={9}, journal={ChemBioChem}, publisher={Wiley}, author={Walsh, Steven and Gardner, Laura and Deiters, Alexander and Williams, Gavin J.}, year={2014}, month={May}, pages={1346–1351} } @article{ye_williams_2014, title={Mapping a Ketosynthase:Acyl Carrier Protein Binding Interface via Unnatural Amino Acid-Mediated Photo-Cross-Linking}, volume={53}, ISSN={0006-2960 1520-4995}, url={http://dx.doi.org/10.1021/bi500936u}, DOI={10.1021/bi500936u}, number={48}, journal={Biochemistry}, publisher={American Chemical Society (ACS)}, author={Ye, Zhixia and Williams, Gavin J.}, year={2014}, month={Nov}, pages={7494–7502} } @article{ye_musiol_weber_williams_2014, title={Reprogramming Acyl Carrier Protein Interactions of an Acyl-CoA Promiscuous trans-Acyltransferase}, volume={21}, ISSN={1074-5521}, url={http://dx.doi.org/10.1016/j.chembiol.2014.02.019}, DOI={10.1016/j.chembiol.2014.02.019}, number={5}, journal={Chemistry & Biology}, publisher={Elsevier BV}, author={Ye, Zhixia and Musiol, Ewa M. and Weber, Tilmann and Williams, Gavin J.}, year={2014}, month={May}, pages={636–646} } @inproceedings{koryakina_williams_2014, place={Washington, DC}, title={Synthetic Biology Approaches For Combinatorial Biosynthesis Of Polyketide Natural Products.}, booktitle={Abstracts of Papers for the American Chemical Society}, publisher={American Chemical Society}, author={Koryakina, I. and Williams, G.J.}, year={2014}, month={Mar} } @article{williams_2013, title={Engineering polyketide synthases and nonribosomal peptide synthetases}, volume={23}, ISSN={0959-440X}, url={http://dx.doi.org/10.1016/j.sbi.2013.06.012}, DOI={10.1016/j.sbi.2013.06.012}, number={4}, journal={Current Opinion in Structural Biology}, publisher={Elsevier BV}, author={Williams, Gavin J}, year={2013}, month={Aug}, pages={603–612} } @article{koryakina_mcarthur_draelos_williams_2013, title={Promiscuity of a modular polyketide synthase towards natural and non-natural extender units}, volume={11}, ISSN={1477-0520 1477-0539}, url={http://dx.doi.org/10.1039/c3ob40633d}, DOI={10.1039/c3ob40633d}, number={27}, journal={Organic & Biomolecular Chemistry}, publisher={Royal Society of Chemistry (RSC)}, author={Koryakina, Irina and McArthur, John B. and Draelos, Matthew M. and Williams, Gavin J.}, year={2013}, pages={4449} } @inbook{williams_koryakina_mcarthur_draelos_randal_muddimanl_2013, series={ACS Symposium Series}, title={Reprogramming the Biosynthesis of Natural Products by Directed Evolution}, ISBN={0841229104 0841229112}, ISSN={0097-6156 1947-5918}, url={http://dx.doi.org/10.1021/bk-2013-1125.ch009}, DOI={10.1021/bk-2013-1125.ch009}, booktitle={Developments in Biotechnology and Bioprocessing}, publisher={American Chemical Society}, author={Williams, Gavin and Koryakina, Irina and McArthur, John and Draelos, Matthew and Randal, Shan and Muddimanl, David}, editor={Kantardjieff, Anne and Asuri, Prashanth and Coffman, Jonathan L. and Jayapal, KarthikEditors}, year={2013}, month={Jan}, pages={147–163}, collection={ACS Symposium Series} } @inbook{mcarthur_williams_2012, place={Weinheim}, title={Engineering Glycosyltransferases}, volume={3}, ISBN={9783527666997}, booktitle={The Protein Engineering Handbook}, publisher={Wiley-HCH}, author={McArthur, J. and Williams, G.J.}, editor={Lutz, S and Bornscheuer, U.T.Editors}, year={2012}, pages={303–326} } @article{koryakina_mcarthur_randall_draelos_musiol_muddiman_weber_williams_2012, title={Poly Specific trans-Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases}, volume={8}, ISSN={1554-8929 1554-8937}, url={http://dx.doi.org/10.1021/cb3003489}, DOI={10.1021/cb3003489}, number={1}, journal={ACS Chemical Biology}, publisher={American Chemical Society (ACS)}, author={Koryakina, Irina and McArthur, John and Randall, Shan and Draelos, Matthew M. and Musiol, Ewa M. and Muddiman, David C. and Weber, Tilmann and Williams, Gavin J.}, year={2012}, month={Oct}, pages={200–208} } @inproceedings{koryakina_ye_mcarthur_williams_2012, place={Washington, DC}, title={Reprogramming the biosynthesis of natural products by directed evolution.}, booktitle={Abstracts of Papers of the American Chemical Society}, publisher={American Chemical Society}, author={Koryakina, I. and Ye, Z. and McArthur, J. and Williams, G.J.}, year={2012}, month={Mar} } @article{koryakina_neville_nonaka_van lanen_williams_2011, title={A High-Throughput Screen for Directed Evolution of the Natural Product Sulfotransferase LipB}, volume={16}, ISSN={1087-0571 1552-454X}, url={http://dx.doi.org/10.1177/1087057111413273}, DOI={10.1177/1087057111413273}, abstractNote={ In this article, the authors describe a colorimetric, high-throughput assay suitable for optimizing the activity of the recently discovered sulfotransferase LipB, by directed evolution. Crucially, LipB uses para-nitrophenol sulfate as donor in the sulfation of the nucleoside antibiotic liposidomycin B-I and other acceptor surrogates. Thus, using a robotic liquid-handling device, crude cell extracts were prepared from an Escherichia coli strain that overproduced LipB in wells of a microplate, and production of para-nitrophenol at 405 nm was monitored spectrophotometrically. Enzyme activity could be detected only in the presence of both LipB substrates and overexpressed LipB. The screen displays a suitable standard deviation for directed evolution and importantly is not limited to the natural desulfo-liposidomycin acceptor. The authors plan to use the screen to identify LipB variants with altered acceptor specificity and promiscuity for use in sulfation of natural products and other small-molecule therapeutics. }, number={8}, journal={Journal of Biomolecular Screening}, publisher={SAGE Publications}, author={Koryakina, Irina and Neville, Jessica and Nonaka, Koichi and Van Lanen, Steven G. and Williams, Gavin J.}, year={2011}, month={Jul}, pages={845–851} } @article{parajuli_williams_2011, title={A high-throughput screen for directed evolution of aminocoumarin amide synthetases}, volume={419}, ISSN={0003-2697}, url={http://dx.doi.org/10.1016/j.ab.2011.07.037}, DOI={10.1016/j.ab.2011.07.037}, number={1}, journal={Analytical Biochemistry}, publisher={Elsevier BV}, author={Parajuli, Niranjan and Williams, Gavin J.}, year={2011}, month={Dec}, pages={61–66} } @article{ye_bair_desai_williams_2011, title={A photocrosslinking assay for reporting protein interactions in polyketide and fatty acid synthases}, volume={7}, ISSN={1742-206X 1742-2051}, url={http://dx.doi.org/10.1039/c1mb05270e}, DOI={10.1039/c1mb05270e}, number={11}, journal={Molecular BioSystems}, publisher={Royal Society of Chemistry (RSC)}, author={Ye, Zhixia and Bair, Morgan and Desai, Hemant and Williams, Gavin J.}, year={2011}, pages={3152} } @article{koryakina_williams_2011, title={Inside Cover: Mutant Malonyl-CoA Synthetases with Altered Specificity for Polyketide Synthase Extender Unit Generation (ChemBioChem 15/2011)}, volume={12}, ISSN={1439-4227}, url={http://dx.doi.org/10.1002/cbic.201190070}, DOI={10.1002/cbic.201190070}, number={15}, journal={ChemBioChem}, publisher={Wiley}, author={Koryakina, Irina and Williams, Gavin J.}, year={2011}, month={Oct}, pages={2230–2230} } @article{koryakina_williams_2011, title={Mutant Malonyl-CoA Synthetases with Altered Specificity for Polyketide Synthase Extender Unit Generation}, volume={12}, ISSN={1439-4227}, url={http://dx.doi.org/10.1002/cbic.201100383}, DOI={10.1002/cbic.201100383}, number={15}, journal={ChemBioChem}, publisher={Wiley}, author={Koryakina, Irina and Williams, Gavin J.}, year={2011}, month={Aug}, pages={2289–2293} } @article{williams_yang_zhang_thorson_2011, title={Recombinant E. coli Prototype Strains for in Vivo Glycorandomization}, volume={6}, ISSN={1554-8929 1554-8937}, url={http://dx.doi.org/10.1021/cb100267k}, DOI={10.1021/cb100267k}, number={1}, journal={ACS Chemical Biology}, publisher={American Chemical Society (ACS)}, author={Williams, Gavin J. and Yang, Jie and Zhang, Changsheng and Thorson, Jon S.}, year={2011}, month={Jan}, pages={95–100} } @inbook{williams_thorson_2009, title={Natural Product Glycosyltransferases: Properties and Applications}, ISBN={9780470392881 9780471235842}, ISSN={1934-4694}, url={http://dx.doi.org/10.1002/9780470392881.ch2}, DOI={10.1002/9780470392881.ch2}, booktitle={Advances in Enzymology - and Related Areas of Molecular Biology}, publisher={John Wiley & Sons, Inc.}, author={Williams, Gavin J. and Thorson, Jon S.}, year={2009}, month={May}, pages={55–119} } @article{williams_thorson_2008, title={A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution}, volume={3}, ISSN={1754-2189 1750-2799}, url={http://dx.doi.org/10.1038/nprot.2007.538}, DOI={10.1038/nprot.2007.538}, number={3}, journal={Nature Protocols}, publisher={Springer Science and Business Media LLC}, author={Williams, Gavin J and Thorson, Jon S}, year={2008}, month={Feb}, pages={357–362} } @article{williams_goff_zhang_thorson_2008, title={Optimizing Glycosyltransferase Specificity via “Hot Spot” Saturation Mutagenesis Presents a Catalyst for Novobiocin Glycorandomization}, volume={15}, ISSN={1074-5521}, url={http://dx.doi.org/10.1016/j.chembiol.2008.02.017}, DOI={10.1016/j.chembiol.2008.02.017}, number={4}, journal={Chemistry & Biology}, publisher={Elsevier BV}, author={Williams, Gavin J. and Goff, Randal D. and Zhang, Changsheng and Thorson, Jon S.}, year={2008}, month={Apr}, pages={393–401} } @article{gantt_goff_williams_thorson_2008, title={Probing the Aglycon Promiscuity of an Engineered Glycosyltransferase}, volume={47}, ISSN={1433-7851 1521-3773}, url={http://dx.doi.org/10.1002/anie.200803508}, DOI={10.1002/anie.200803508}, number={46}, journal={Angewandte Chemie International Edition}, publisher={Wiley}, author={Gantt, Richard W. and Goff, Randal D. and Williams, Gavin J. and Thorson, Jon S.}, year={2008}, month={Nov}, pages={8889–8892} } @article{williams_gantt_thorson_2008, title={The impact of enzyme engineering upon natural product glycodiversification}, volume={12}, ISSN={1367-5931}, url={http://dx.doi.org/10.1016/j.cbpa.2008.07.013}, DOI={10.1016/j.cbpa.2008.07.013}, number={5}, journal={Current Opinion in Chemical Biology}, publisher={Elsevier BV}, author={Williams, Gavin J and Gantt, Richard W and Thorson, Jon S}, year={2008}, month={Oct}, pages={556–564} } @article{nelson_williams_woodhall_farnsworth_berry_2007, title={Stereochemically Complementary Biocatalysts Created by Directed Evolution}, volume={2007}, ISSN={1861-1958 1861-194X}, url={http://dx.doi.org/10.1055/s-2006-955791}, DOI={10.1055/s-2006-955791}, number={2}, journal={Synfacts}, publisher={Georg Thieme Verlag KG}, author={Nelson, A. and Williams, G. and Woodhall, T. and Farnsworth, L. and Berry, A.}, year={2007}, month={Feb}, pages={0208–0208} } @article{williams_woodhall_farnsworth_nelson_berry_2006, title={Creation of a Pair of Stereochemically Complementary Biocatalysts}, volume={128}, ISSN={0002-7863 1520-5126}, url={http://dx.doi.org/10.1021/ja065233q}, DOI={10.1021/ja065233q}, number={50}, journal={Journal of the American Chemical Society}, publisher={American Chemical Society (ACS)}, author={Williams, Gavin J. and Woodhall, Thomas and Farnsworth, Lorna M. and Nelson, Adam and Berry, Alan}, year={2006}, month={Dec}, pages={16238–16247} } @article{williams_woodhall_nelson_berry_2005, title={Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis of sialic acid mimetics}, volume={18}, ISSN={1741-0134 1741-0126}, url={http://dx.doi.org/10.1093/protein/gzi027}, DOI={10.1093/protein/gzi027}, number={5}, journal={Protein Engineering, Design and Selection}, publisher={Oxford University Press (OUP)}, author={Williams, G.J. and Woodhall, T. and Nelson, A. and Berry, A.}, year={2005}, month={May}, pages={239–246} } @article{williams_berry_2003, title={Directed evolution: Creating new enzymes}, volume={25}, DOI={10.1042/BIO02504013}, number={4}, journal={The Biochemist}, author={Williams, G.J. and Berry, A.}, year={2003}, month={Aug}, pages={13–15} } @article{williams_domann_nelson_berry_2003, title={Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution}, volume={100}, ISSN={0027-8424 1091-6490}, url={http://dx.doi.org/10.1073/pnas.0635924100}, DOI={10.1073/pnas.0635924100}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Williams, G. J. and Domann, S. and Nelson, A. and Berry, A.}, year={2003}, month={Mar}, pages={3143–3148} }