Gina Marie Hilton

Works (4)

Updated: July 15th, 2023 21:16

2018 journal article

Leveraging proteomics to compare submerged versus air-liquid interface carbon nanotube exposure to a 3D lung cell model

TOXICOLOGY IN VITRO, 54, 58–66.

By: G. Hilton n, H. Barosova *, A. Petri-Fink *, B. Rothen-Rutishauser * & M. Bereman n

author keywords: Carbon nanotubes; Lung cell co-cultures; Air-liquid interface; In vitro assay development; Label-free proteomics; Toxicoproteomics
MeSH headings : Cell Line; Coculture Techniques; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Fibroblasts / drug effects; Fibroblasts / metabolism; Humans; Lung / cytology; Macrophages / drug effects; Macrophages / metabolism; Nanotubes, Carbon / toxicity; Proteomics; Toxicity Tests
TL;DR: Comparison of MWCNT exposure methods yielded protein enrichment in pathways known to be associated with carbon nanotube exposure stress response, such as acute phase response signaling and NRF2-mediated oxidative stress response. (via Semantic Scholar)
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Source: Web Of Science
Added: January 14, 2019

2017 journal article

Mapping differential cellular protein response of mouse alveolar epithelial cells to multi-walled carbon nanotubes as a function of atomic layer deposition coating

NANOTOXICOLOGY, 11(3), 313–326.

By: G. Hilton n, A. Taylor n, S. Hussain *, E. Dandley n, E. Griffith n , S. Garantziotis *, G. Parsons n , J. Bonner n , M. Bereman n

author keywords: Carbon nanotube; label-free proteomics; pulmonary fibrosis; toxicoproteomics
MeSH headings : Aluminum Oxide / toxicity; Alveolar Epithelial Cells / chemistry; Alveolar Epithelial Cells / drug effects; Animals; Cells, Cultured; Mice; Nanotubes, Carbon / toxicity; Proteomics / methods; Pulmonary Fibrosis / etiology; Zinc Oxide / toxicity
TL;DR: It is demonstrated that specific types of metal oxide thin film coatings applied by ALD produce distinct cellular and biochemical responses related to lung inflammation and fibrosis compared to uncoated MWCNT exposure in vitro. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Toxicoproteomic analysis of pulmonary carbon nanotube exposure using LC-MS/MS

TOXICOLOGY, 329, 80–87.

By: G. Hilton n, A. Taylor n, C. McClure n, G. Parsons n , J. Bonner n  & M. Bereman n

Contributors: G. Hilton n, A. Taylor n, C. McClure n, G. Parsons n , J. Bonner n  & M. Bereman n

author keywords: Carbon nanotube; Label-free proteomics; Pulmonary fibrosis; Toxicoproteomics
MeSH headings : Acute-Phase Proteins / genetics; Acute-Phase Proteins / metabolism; Animals; Bronchoalveolar Lavage Fluid / chemistry; Chromatography, Liquid; Complement C3 / genetics; Complement C3 / metabolism; Complement C4b / genetics; Complement C4b / metabolism; Complement C9 / genetics; Complement C9 / metabolism; Histones / genetics; Histones / metabolism; Lactoferrin / genetics; Lactoferrin / metabolism; Lipocalin-2; Lipocalins / genetics; Lipocalins / metabolism; Lung / drug effects; Lung / metabolism; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Oncogene Proteins / genetics; Oncogene Proteins / metabolism; Peroxidase / genetics; Peroxidase / metabolism; Proteome / metabolism; Pulmonary Surfactant-Associated Protein B / genetics; Pulmonary Surfactant-Associated Protein B / metabolism; Tandem Mass Spectrometry; Toxicity Tests
TL;DR: The protein secretion profile in lung bronchoalveolar lavage fluid from mice exposed to non-functionalized multi-walled carbon nanotubes or MWCNTs functionalized by nanoscale Al2O3 coatings formed using atomic layer deposition (ALD) was compared. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Is Helicobacter Pylori an endogenous source of diethyl phthalate in humans?

Environmental Research, 134, 402–404.

By: G. Hilton n & J. Hoppin n 

author keywords: Diethyl phthalate; Monoethyl phthalate; Helicobacter pylori; NHANES; Microbiome
MeSH headings : Adolescent; Adult; Female; Helicobacter pylori / metabolism; Humans; Male; Middle Aged; Phthalic Acids / metabolism; Young Adult
TL;DR: Results suggest that HP may be an endogenous source of DEP in some populations, and MEP levels were higher in individuals with HP seropositivity, however the association differed by race. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

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