Grace Scheidemantle

Works (5)

Updated: May 23rd, 2024 05:00

2024 journal article

Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism

METABOLOMICS, 20(3).

By: G. Scheidemantle n, L. Duan n, M. Lodge n, M. Cummings  n, D. Hilovsky n, E. Pham n, X. Wang n , A. Kennedy n , X. Liu n

author keywords: Metformin; Intestinal metabolism; Lipidomics; DIA
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Sources: Web Of Science, NC State University Libraries
Added: May 20, 2024

2024 journal article

Myeloid cell MHC I expression drives CD8<SUP>+</SUP> T cell activation in nonalcoholic steatohepatitis

FRONTIERS IN IMMUNOLOGY, 14.

By: V. Adams n, L. Collins n , T. Williams n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Contributors: T. Williams n , V. Adams n, L. Collins n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Ed(s): T. Williams n , L. Collins n  & A. Kennedy n 

author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
TL;DR: Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 28, 2024

2023 journal article

Histone malonylation is regulated by SIRT5 and KAT2A

ISCIENCE, 26(3).

By: R. Zhang *, J. Bons *, G. Scheidemantle n, X. Liu n, O. Bielska *, C. Carrico *, J. Rose *, I. Heckenbach * ...

TL;DR: The role of histone malonylation in ribosomal gene expression is highlighted by mass spectrometry and it is reported that availability of malonyl-co-enzyme A (malonyL-CoA), an endogenous provider ofmalonyl groups, affects lysinemalonylation, and that the deacylase SIRT5 selectively reduces malonylated of histones. (via Semantic Scholar)
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Source: Web Of Science
Added: June 12, 2023

2022 journal article

C-13 tracer analysis suggests extensive recycling of endogenous CO2 in vivo

CANCER & METABOLISM, 10(1).

By: L. Duan n, D. Cooper *, G. Scheidemantle n, J. Locasale *, D. Kirsch * & X. Liu n

author keywords: C-13 tracing; High-resolution mass spectrometry; Anaplerotic metabolism; CO2 recycling
TL;DR: The results show that recycling of endogenous CO2 is substantial in vivo and incorporation of endogenous 13CO2 into M’+ 1 metabolites is substantial and should be considered, and provide a new paradigm to understand carbon atom transformations in vivo. (via Semantic Scholar)
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Source: Web Of Science
Added: July 18, 2022

2022 journal article

Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC-MS/MS-based lipidomics analysis

METABOLOMICS, 18(8).

By: L. Duan n, G. Scheidemantle n, M. Lodge n, M. Cummings  n, E. Pham n, X. Wang n , A. Kennedy n , X. Liu n

MeSH headings : Animals; Cardiolipins; Chromatography, Liquid / methods; Ions; Lipidomics; Metabolomics; Mice; Reproducibility of Results; Tandem Mass Spectrometry / methods
TL;DR: A novel workflow using biologically relevant lipids to construct inclusion list for data-independent acquisition (DIA), named as BRI-DIA workflow, which is as efficient as traditional DDA method in profiling lipids, but offers better consistency of lipid identification, compared to D DA method. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022

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