Grace Scheidemantle

Works (5)

Updated: April 23rd, 2025 19:27

2024 article

Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism

Scheidemantle, G., Duan, L., Lodge, M., Cummings, M. J., Hilovsky, D., Pham, E., … Liu, X. (2024, May 9). Metabolomics, Vol. 20.

By: G. Scheidemantle n, L. Duan n, M. Lodge n, M. Cummings n, D. Hilovsky n, E. Pham n, X. Wang n , A. Kennedy n , X. Liu n

author keywords: Metformin; Intestinal metabolism; Lipidomics; DIA
MeSH headings : Metformin / pharmacology; Metformin / metabolism; Animals; Mice; Male; Lipidomics / methods; Lipid Metabolism / drug effects; Lipids / blood; Hypoglycemic Agents / pharmacology; Hypoglycemic Agents / metabolism; Mice, Inbred C57BL; Tandem Mass Spectrometry / methods
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Advanced Proteomics Techniques and Applications; Metabolism, Diabetes, and Cancer
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Sources: Web Of Science, NC State University Libraries
Added: May 20, 2024

2024 article

Myeloid cell MHC I expression drives CD8+ T cell activation in nonalcoholic steatohepatitis

Adams, V. R., Collins, L. B., Williams, T. I., Holmes, J., Hess, P., Atkins, H. M., … Kennedy, A. (2024, January 11). (T. I. Williams, L. B. Collins, & A. Kennedy, Eds.). Frontiers in Immunology, Vol. 14.

By: V. Adams n, L. Collins n , T. Williams n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Contributors: T. Williams n , V. Adams n, L. Collins n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Ed(s): T. Williams n , L. Collins n  & A. Kennedy n 

author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
MeSH headings : Animals; Mice; Non-alcoholic Fatty Liver Disease / pathology; CD8-Positive T-Lymphocytes; Inflammation; Myeloid Cells / metabolism; Mice, Transgenic; Fibrosis; Cytokines / metabolism
topics (OpenAlex): Immune Cell Function and Interaction; Liver Disease Diagnosis and Treatment; Immune cells in cancer
TL;DR: Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 28, 2024

2023 article

Histone malonylation is regulated by SIRT5 and KAT2A

Zhang, R., Bons, J., Scheidemantle, G., Liu, X., Bielska, O., Carrico, C., … Verdin, E. (2023, February 13). IScience.

By: R. Zhang *, J. Bons *, G. Scheidemantle n, X. Liu n, O. Bielska *, C. Carrico *, J. Rose *, I. Heckenbach * ...

topics (OpenAlex): Sirtuins and Resveratrol in Medicine; Histone Deacetylase Inhibitors Research; Biotin and Related Studies
TL;DR: The role of histone malonylation in ribosomal gene expression is highlighted by mass spectrometry and it is reported that availability of malonyl-co-enzyme A (malonyL-CoA), an endogenous provider ofmalonyl groups, affects lysinemalonylation, and that the deacylase SIRT5 selectively reduces malonylated of histones. (via Semantic Scholar)
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Source: Web Of Science
Added: June 12, 2023

2022 article

13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo

Duan, L., Cooper, D. E., Scheidemantle, G., Locasale, J. W., Kirsch, D. G., & Liu, X. (2022, July 7). Cancer & Metabolism.

By: L. Duan n, D. Cooper *, G. Scheidemantle n, J. Locasale *, D. Kirsch * & X. Liu n

author keywords: C-13 tracing; High-resolution mass spectrometry; Anaplerotic metabolism; CO2 recycling
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Metabolomics and Mass Spectrometry Studies; Mitochondrial Function and Pathology; Diet and metabolism studies
TL;DR: The results show that recycling of endogenous CO2 is substantial in vivo and incorporation of endogenous 13CO2 into M’+ 1 metabolites is substantial and should be considered, and provide a new paradigm to understand carbon atom transformations in vivo. (via Semantic Scholar)
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Source: Web Of Science
Added: July 18, 2022

2022 article

Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC–MS/MS-based lipidomics analysis

Duan, L., Scheidemantle, G., Lodge, M., Cummings, M. J., Pham, E., Wang, X., … Liu, X. (2022, July 16). Metabolomics, Vol. 7.

By: L. Duan n, G. Scheidemantle n, M. Lodge n, M. Cummings n, E. Pham n, X. Wang n , A. Kennedy n , X. Liu n

MeSH headings : Animals; Cardiolipins; Chromatography, Liquid / methods; Ions; Lipidomics; Metabolomics; Mice; Reproducibility of Results; Tandem Mass Spectrometry / methods
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Mitochondrial Function and Pathology; Advanced Proteomics Techniques and Applications
TL;DR: A novel workflow using biologically relevant lipids to construct inclusion list for data-independent acquisition (DIA), named as BRI-DIA workflow, which is as efficient as traditional DDA method in profiling lipids, but offers better consistency of lipid identification, compared to D DA method. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022

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