Glenn Cruse

Gracioso Martins, A. M., Snider, D. B., Popowski, K. D., Schuchard, K. G., Tenorio, M., Akunuri, S., … Cruse, G. P. (2023). Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice. Journal of Controlled Release, 359, 287–301. https://doi.org/10.1016/j.jconrel.2023.05.039

Hedgespeth, B. A. A., Snider, D. B., Bitting, K. J., & Cruse, G. (2023). The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis. FRONTIERS IN IMMUNOLOGY, 14. https://doi.org/10.3389/fimmu.2023.1006741

Bitting, K., Hedgespeth, B., Ehrhardt-Humbert, L. C., Arthur, G. K., Schubert, A. G., Bradding, P., … Cruse, G. (2022, December 7). Identification of redundancy between human Fc epsilon RI beta and MS4A6A proteins points toward additional complex mechanisms for Fc epsilon RI trafficking and signaling. ALLERGY, Vol. 78. https://doi.org/10.1111/all.15595

Cortes, L. M., Brodsky, D., Chen, C., Pridgen, T., Odle, J., Snider, D. B., … Kaser, T. (2022). Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis. FRONTIERS IN ALLERGY, 3. https://doi.org/10.3389/falgy.2022.1029184

Arthur, G. K., & Cruse, G. (2022). Regulation of Trafficking and Signaling of the High Affinity IgE Receptor by Fc epsilon RI beta and the Potential Impact of Fc epsilon RI beta Splicing in Allergic Inflammation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(2). https://doi.org/10.3390/ijms23020788

Snider, D. B., Arthur, G. K., Falduto, G. H., Olivera, A., Ehrhardt-Humbert, L. C., Smith, E., … Cruse, G. (2022). Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms. MOLECULAR THERAPY, 30(1), 295–310. https://doi.org/10.1016/j.ymthe.2021.08.009

Ozpinar, E. W., Frey, A. L., Arthur, G. K., Mora-Navarro, C., Biehl, A., Snider, D. B., … Freytes, D. O. (2021). Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation. TISSUE ENGINEERING PART A, 27(15-16), 1008–1022. https://doi.org/10.1089/ten.tea.2020.0142

Kong, X., Bennett, W. C., Jania, C. M., Chason, K. D., German, Z., Adouli, J., … Tilley, S. L. (2021). Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness. JCI INSIGHT, 6(21). https://doi.org/10.1172/jci.insight.140207

Ozpinar, E. W., Frey, A. L., Cruse, G., & Freytes, D. O. (2021). Mast Cell-Biomaterial Interactions and Tissue Repair. TISSUE ENGINEERING PART B-REVIEWS, 27(6), 590–603. https://doi.org/10.1089/ten.teb.2020.0275

Chee, E., Nandi, S., Nellenbach, K., Mihalko, E., Snider, D. B., Morrill, L., … Brown, A. C. (2020). Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(6), 2599–2609. https://doi.org/10.1002/jbm.b.34592

Mishra, S. K., Wheeler, J. J., Pitake, S., Ding, H., Jiang, C., Fukuyama, T., … Olivry, T. (2020). Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. CELL REPORTS, 31(1). https://doi.org/10.1016/j.celrep.2020.03.036

Arthur, G. K., Ehrhardt-Humbert, L. C., Snider, D. B., Jania, C., Tilley, S. L., Metcalfe, D. D., & Cruse, G. (2020). The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells. Cellular Signalling, 71, 109617. https://doi.org/10.1016/j.cellsig.2020.109617

Mishra, S. K., Wheeler, J., Pitake, S., Ding, H., Jiang, C., Fukuyama, T., … Olivry, T. (2019). The Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. SSRN. https://doi.org/10.2139/ssrn.3459205

Arthur, G. K., & Cruse, G. (2018). Exon Skipping of Fc epsilon RI beta for Allergic Diseases. EXON SKIPPING AND INCLUSION THERAPIES: METHODS AND PROTOCOLS, Vol. 1828, pp. 503–518. https://doi.org/10.1007/978-1-4939-8651-4_33

Kim, D., Beaven, M. A., Kulinski, J., Desai, A., Cruse, G., Prussin, C., … Olivera, A. (2016). Constitutive KIT Activity and IL-6 Production in Mast Cells Alters Levels of Reactive Oxygen Species (ROS) and the Scavenger Protein DJ-1 in Mastocytosis. Journal of Allergy and Clinical Immunology, 137(2), AB281. https://doi.org/10.1016/J.JACI.2015.12.1168

Cruse, G., Yin, Y., Fukuyama, T., Desai, A., Arthur, G. K., Baumer, W., … Metcalfe, D. D. (2016). Exon skipping of Fc epsilon RI beta eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(49), 14115–14120. https://doi.org/10.1073/pnas.1608520113

Immunophenotypic and ultrastructural analysis of mast cells in hermansky-pudlak syndrome type-1: A possible connection to pulmonary fibrosis. (2016). PLoS ONE, 11(7). https://doi.org/10.1371/journal.pone.0159177

Cruse, G., & Bradding, P. (2016). Mast cells in airway diseases and interstitial lung disease. European Journal of Pharmacology, 778, 125–138. https://doi.org/10.1016/j.ejphar.2015.04.046

Boyden, S. E., Desai, A., Cruse, G., Young, M. L., Bolan, H. C., Scott, L. M., … Komarow, H. D. (2016). Vibratory urticaria associated with a missense variant in ADGRE2. New England Journal of Medicine, 374(7), 656–663. https://doi.org/10.1056/NEJMoa1500611

Kim, D., Beaven, M. A., Cruse, G., Prussin, C., Komarow, H., Carter, M. C., … Olivera, A. (2015). Constitutively Activated KIT in Mastocytosis Patients Is Associated with Decreased Levels of the Scavenger Protein DJ1 and Reciprocal Increases in Reactive Oxygen Species. Journal of Allergy and Clinical Immunology, 135(2), AB389. https://doi.org/10.1016/J.JACI.2014.12.1900

Cruse, G., Gilfillan, A. M., & Smrz, D. (2015). Flow cytometry-based monitoring of mast cell activation. In Methods in Molecular Biology (Vol. 1220, pp. 365–379). https://doi.org/10.1007/978-1-4939-1568-2_23

Kirshenbaum, A. S., Bandara, G., Desai, A., Fischer, E., Leerkes, M., Metcalfe, D. D., & Cruse, G. (2015). Mast Cells Expressing the Germline HPS1 16-Bp Duplication (c.1470_1486dup16, Hermansky-Pudlak Syndrome-1) Defect Produce Extracellular Matrix Components. Journal of Allergy and Clinical Immunology, 135(2), AB172. https://doi.org/10.1016/J.JACI.2014.12.1497

Cruse, G., Beaven, M. A., Music, S. C., Bradding, P., Gilfillan, A. M., & Metcalfe, D. D. (2015). The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling. Molecular Biology of the Cell, 26(9), 1711–1727. https://doi.org/10.1091/mbc.E14-07-1221

Cruse, G., Beaven, M. A., Music, S. C., Bradding, P., & Metcalfe, D. D. (2015). The Fcεriβ Homologue, MS4A4, Promotes Fcεri-Dependent Human Mast Cell Degranulation By Facilitating PLCγ1 Signaling. Journal of Allergy and Clinical Immunology, 135(2), AB240. https://doi.org/10.1016/J.JACI.2014.12.1718

Cruse, G., Metcalfe, D. D., & Olivera, A. (2014). Functional deregulation of KIT: Link to mast cell proliferative diseases and other neoplasms. Immunology and Allergy Clinics of North America, 34(2), 219–237. https://doi.org/10.1016/j.iac.2014.01.002

Smrz, D., Cruse, G., Beaven, M. A., Kirshenbaum, A., Metcalfe, D. D., & Gilfillan, A. M. (2014). Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation. Journal of Immunology, 193(12), 5924–5932. https://doi.org/10.4049/jimmunol.1303495

Cruse, G., Beaven, M., Ashmole, I., Bradding, P., Gilfillan, A., & Metcalfe, D. (2013). A Truncated Splice-Variant of the FcεRIβ Receptor Subunit Is Critical for Microtubule Formation and Degranulation in Mast Cells. Immunity, 38(5), 906–917. https://doi.org/10.1016/j.immuni.2013.04.007

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. (2013). Journal of Allergy and Clinical Immunology, 132(6). https://doi.org/10.1016/j.jaci.2013.08.045)

Siegel, A. M., Stone, K. D., Cruse, G., Lawrence, M. G., Olivera, A., Jung, M.-yeon, … Milner, J. D. (2013). Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. Journal of Allergy and Clinical Immunology, 132(6), 1388–1396.e3. https://doi.org/10.1016/J.JACI.2013.08.045

Kirshenbaum, A., Desai, A., Bandara, G., Cruse, G., Fischer, E., Gilfillan, A. M., … Metcalfe, D. D. (2013). Establishment of the Hermansky Pudlak Mastocyte (HPM) Cell Line Which Has the HPS1 16-Bp Duplication (c.1470_1486dup16). Journal of Allergy and Clinical Immunology, 131(2), AB115. https://doi.org/10.1016/j.jaci.2012.12.1081

Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., … Milner, J. D. (2012). Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. New England Journal of Medicine, 366(4), 330–338. https://doi.org/10.1056/NEJMoa1102140

Cruse, G., Singh, S. R., Duffy, S. M., Doe, C., Saunders, R., Brightling, C. E., & Bradding, P. (2011). Functional K<inf>Ca</inf>3.1 K<sup>+</sup> channels are required for human fibrocyte migration. Journal of Allergy and Clinical Immunology, 128(6). https://doi.org/10.1016/j.jaci.2011.07.047

Cruse, G., Kaur, D., Leyland, M., & Bradding, P. (2010). A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival. FASEB Journal, 24(10), 4047–4057. https://doi.org/10.1096/fj.10-158378

Kajiwara, N., Sasaki, T., Bradding, P., Cruse, G., Sagara, H., Ohmori, K., … Okayama, Y. (2010). Activation of human mast cells through the platelet-activating factor receptor. Journal of Allergy and Clinical Immunology, 125(5). https://doi.org/10.1016/j.jaci.2010.01.056

Kaur, D., Hollins, F., Saunders, R., Woodman, L., Sutcliffe, A., Cruse, G., … Brightling, C. (2010). Airway smooth muscle proliferation and survival is not modulated by mast cells. Clinical and Experimental Allergy, 40(2), 279–288. https://doi.org/10.1111/j.1365-2222.2009.03423.x

Cruse, G., Yang, W., Duffy, S. M., Chachi, L., Leyland, M., Amrani, Y., & Bradding, P. (2010). Counterregulation of β<inf>2</inf>-adrenoceptor function in human mast cells by stem cell factor. Journal of Allergy and Clinical Immunology, 125(1-3). https://doi.org/10.1016/j.jaci.2009.08.020

Cruse, G., Fernandes, V. E., De Salort, J., Pankhania, D., Marinas, M. S., Brewin, H., … Kadioglu, A. (2010). Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin. Journal of Immunology, 184(12), 7108–7115. https://doi.org/10.4049/jimmunol.0900802

Siddiqui, S., Gupta, S., Cruse, G., Haldar, P., Entwisle, J., McDonald, S., … Brightling, C. E. (2009). Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis. Allergy: European Journal of Allergy and Clinical Immunology, 64(6), 951–958. https://doi.org/10.1111/j.1398-9995.2009.01951.x

Siddiqui, S., Cruse, G., Mckenna, S., Monteiro, W., Mistry, V., Wardlaw, A., & Brightling, C. (2009). IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis. BMC Pulmonary Medicine, 9. https://doi.org/10.1186/1471-2466-9-34

Bradding, P., & Cruse, G. (2009). Mast Cells: Biological Properties and Role in Health and Allergic Diseases. In Allergy and Allergic Diseases, Second Edition (Vol. 1, pp. 217–257). https://doi.org/10.1002/9781444300918.ch11

Duffy, S. M., Cruse, G., Cockerill, S. L., Brightling, C. E., & Bradding, P. (2008). Engagement of the EP<inf>2</inf> prostanoid receptor closes the K<sup>+</sup> channel K<inf>Ca</inf>3.1 in human lung mast cells and attenuates their migration. European Journal of Immunology, 38(9), 2548–2556. https://doi.org/10.1002/eji.200738106

Hollins, F., Kaur, D., Yang, W., Cruse, G., Saunders, R., Sutcliffe, A., … Bradding, P. (2008). Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: Cooperative roles for CADM1, stem cell factor, and IL-6. Journal of Immunology, 181(4), 2772–2780. https://doi.org/10.4049/jimmunol.181.4.2772

Cruse, G., Cockerill, S., & Bradding, P. (2008). IgE alone promotes human lung mast cell survival through the autocrine production of IL-6. BMC Immunology, 9. https://doi.org/10.1186/1471-2172-9-2

Woodman, L., Siddiqui, S., Cruse, G., Sutcliffe, A., Saunders, R., Kaur, D., … Brightling, C. (2008). Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-β1. Journal of Immunology, 181(7), 5001–5007. Retrieved from http://www.scopus.com/inward/record.url?eid=2-s2.0-58149280835&partnerID=MN8TOARS

Duffy, S. M., Cruse, G., Brightling, C. E., & Bradding, P. (2007). Adenosine closes the K<sup>+</sup> channel K<inf>Ca</inf>3.1 in human lung mast cells and inhibits their migration via the adenosine A<inf>2A</inf> receptor. European Journal of Immunology, 37(6), 1653–1662. https://doi.org/10.1002/eji.200637024

Shepherd, M. C., Duffy, S. M., Harris, T., Cruse, G., Schuliga, M., Brightling, C. E., … Stewart, A. G. (2007). K<inf>Ca</inf>3.1 Ca<sup>2+</sup>-activated K<sup>+</sup> channels regulate human airway smooth muscle proliferation. American Journal of Respiratory Cell and Molecular Biology, 37(5), 525–531. https://doi.org/10.1165/rcmb.2006-0358OC

Cruse, G., Duffy, S. M., Brightling, C. E., & Bradding, P. (2006). Functional K<inf>Ca</inf>3.1 K<sup>+</sup> channels are required for human lung mast cell migration. Thorax, 61(10), 880–885. https://doi.org/10.1136/thx.2006.060319

Cruse, G., Kaur, D., Yang, W., Duffy, S. M., Brightling, C. E., & Bradding, P. (2005). Activation of human lung mast cells by monomeric immunoglobulin E. European Respiratory Journal, 25(5), 858–863. https://doi.org/10.1183/09031936.05.00091704

Hart, S. P., Dransfield, I., Bradding, P., & Cruse, G. (2005). Activation of human lung mast cells by monomeric immunoglobulin E (multiple letters) [2]. European Respiratory Journal, 26(4), 744–746. https://doi.org/10.1183/09031936.05.00061105

Duffy, S. M., Cruse, G., Lawley, W. J., & Bradding, P. (2005). β<inf>2</inf>-adrenoceptor regulation of the K<sup>+</sup> channel iK<inf>Ca</inf>1 in human mast cells. FASEB Journal, 19(8), 1006–1008. https://doi.org/10.1096/fj.04-3439fje

Mark Duffy, S., Berger, P., Cruse, G., Yang, W., Bolton, S. J., & Bradding, P. (2004). The K <sup>+</sup> channel iK <inf>CA</inf>1 potentiates Ca <sup>2+</sup> influx and degranulation in human lung mast cells. Journal of Allergy and Clinical Immunology, 114(1), 66–72. https://doi.org/10.1016/j.jaci.2004.04.005