@article{southern_neupane_ericson_dencklau_linder_bradley_mckeon_long_breitschwerdt_2018, title={Bartonella henselae in a dog with ear tip vasculitis}, volume={29}, ISSN={0959-4493}, url={http://dx.doi.org/10.1111/vde.12695}, DOI={10.1111/vde.12695}, abstractNote={BackgroundBartonella henselae, a Gram‐negative, zoonotic, alpha‐proteobacteria has been previously implicated in association with cutaneous vasoproliferative lesions (bacillary angiomatosis), nodular panniculitis and multifocal erythema (erythema multiforme) in dogs.ObjectiveDescribe clinical, microbiological and histological lesions in a dog with ear margin vasculitis and B. henselae infection.AnimalsA 12‐month‐old, specific pathogen‐free intact female beagle dog maintained in a vector‐free laboratory animal resource facility.Methods and materialsBartonella and Rickettsia serological evaluation, Bartonella and Rickettsia PCR, Bartonella alpha‐proteobacteria growth medium (BAPGM) enrichment blood culture/PCR, histopathological investigation and confocal immunohistochemical evaluation.ResultsSerological investigation (seroreversion) and PCR testing of aural tissue biopsies failed to support Rickettsia rickettsii as a cause of the aural vasculitis; however, B. henselae, genotype San Antonio 2 DNA was amplified and sequenced from both ear tip margins and from normal‐appearing abdominal skin. Seroconversion to B. henselae was documented retrospectively by IFA testing. Bartonella henselae organisms were visualized by confocal immunostaining within all three biopsies. Histopathology revealed small vessel necrotizing vasculitis and dermal necrosis. Bartonella henselae seroreversion and complete resolution of skin lesions occurred in conjunction with administration of oral doxycycline and enrofloxacin for six weeks.Conclusions and Clinical ImportanceBartonella henselae is an emerging zoonotic pathogen that has been associated with leucocytoclastic vasculitis in humans and may have had a contributing or causative role in the development of the cutaneous aural margin vasculitis in this beagle.}, number={6}, journal={Veterinary Dermatology}, publisher={Wiley}, author={Southern, Brittany L. and Neupane, Pradeep and Ericson, Marna E. and Dencklau, Jamie C. and Linder, Keith E. and Bradley, Julie M. and McKeon, Gabriel P. and Long, Charles T. and Breitschwerdt, Edward B.}, year={2018}, month={Oct}, pages={537–e180} } @article{williams_long_durrant_mckeon_shive_griffith_messenger_fish_2017, title={Oral transmucosal detomidine gel in New Zealand white rabbits (Oryctolagus cuniculus)}, volume={56}, number={4}, journal={Journal of the American Association for Laboratory Animal Science}, author={Williams, M. D. and Long, C. T. and Durrant, J. R. and McKeon, G. P. and Shive, H. R. and Griffith, E. H. and Messenger, K. M. and Fish, R. E.}, year={2017}, pages={436–442} } @article{chum_long_mckeon_chang_luong_albertelli_2014, title={Abdominal lipomatosis with secondary self-strangulation of masses in an adult rhesus macaque (Macaca mulatta)}, volume={64}, number={5}, journal={Comparative Medicine}, author={Chum, H. H. and Long, C. T. and McKeon, G. P. and Chang, A. G. and Luong, R. H. and Albertelli, M. A.}, year={2014}, pages={404–408} } @article{chum_jampachairsri_mckeon_yeomans_pacharinsak_felt_2014, title={Antinociceptive effects of sustained-release buprenorphine in a model of incisional pain in rats (Rattus norvegicus)}, volume={53}, number={2}, journal={Journal of the American Association for Laboratory Animal Science}, author={Chum, H. H. and Jampachairsri, K. and McKeon, G. P. and Yeomans, D. C. and Pacharinsak, C. and Felt, S. A.}, year={2014}, pages={193–197} }