Gregory Robert Bacola

Works (4)

Updated: April 4th, 2024 13:59

2023 article

Mini-Review: Enteric glia of the tumor microenvironment: An affair of corruption

Mariant, C. L., Bacola, G., & Van Landeghem, L. (2023, September 25). NEUROSCIENCE LETTERS, Vol. 814.

By: C. Mariant n, G. Bacola n  & L. Van Landeghem n

author keywords: Enteric glial cell; Colon cancer; Tumor microenvironment; Cancer stem cell; Intestinal stem cell
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Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2023 article

Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis (vol 49, pg 172, 2019)

Vales, S., Bacola, G., Biraud, M., Bessard, A., Geraldo, F., Dougherty, K. A., … Van Landeghem, L. (2023, February). EBIOMEDICINE, Vol. 88.

By: S. Vales*, G. Bacola n , M. Biraud*, A. Bessard*, F. Geraldo*, K. Dougherty n, S. Lashani n, C. Bossard * ...

TL;DR: This research attacked the mode of action of EMTs through a probabilistic route called “ ‘spiking’ the Tournaisian nervous system’ through a number of different mechanisms. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 27, 2023

2019 journal article

Nuclear envelope deformation controls cell cycle progression in response to mechanical force

EMBO REPORTS, 20(9).

By: J. Aureille *, V. Buffiere-Ribot*, B. Harvey*, C. Boyault *, L. Pernet *, T. Andersen *, G. Bacola n , M. Balland * ...

author keywords: AP1; c-Jun; mechanotransduction; nuclear envelope; TEAD
MeSH headings : Cell Cycle / genetics; Cell Cycle / physiology; Cell Division / genetics; Cell Division / physiology; Cell Line; Cell Nucleus / genetics; Cell Nucleus / metabolism; Flow Cytometry; G1 Phase / genetics; G1 Phase / physiology; HeLa Cells; Humans; Mechanotransduction, Cellular / genetics; Mechanotransduction, Cellular / physiology; Microscopy, Atomic Force; Nuclear Envelope / genetics; Nuclear Envelope / metabolism; Plasmids / genetics; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; S Phase / genetics; S Phase / physiology; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: It is shown that applying compressive force on the nucleus in the absence of myosin II‐mediated tension is sufficient to restore G1 to S transition and reveal that the nuclear envelope can operate as a mechanical sensor whose deformation controls cell growth in response to tension. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 19, 2019

2019 journal article

Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis.

EBioMedicine.

Gregory Bacola

author keywords: Enteric glial cells; Colon cancer stem cells; Colorectal cancer: Tumor microenvironment; PGE2
MeSH headings : Animals; Carcinogenesis / metabolism; Carcinogenesis / pathology; Cell Line; Colonic Neoplasms / pathology; Dinoprostone / metabolism; Epithelial Cells / metabolism; Epithelial Cells / pathology; Female; Humans; Interleukin-1 / metabolism; Male; Mice, SCID; Models, Biological; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Neuroglia / pathology; Phenotype; Receptors, Prostaglandin E, EP4 Subtype / metabolism; Signal Transduction; Tumor Microenvironment
TL;DR: Results show that EGCs, once activated by the tumor, acquire a pro-tumorigenic phenotype and stimulate CSC-driven tumorigenesis via a PGE2/EP4/EGFR-dependent pathway. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: December 3, 2019

Employment

Updated: December 2nd, 2019 11:00

2017 - present

North Carolina State University Raleigh, NC, US
Graduate Research Assistant Molecular Biomedical Sciences

Education

Updated: December 2nd, 2019 11:01

2012 - 2017

North Carolina State University Raleigh, North Carolina, US
Bachelor of Science

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