Gregory S McCarty

Works (37)

Updated: April 4th, 2024 09:18

2023 article

Exploiting Microelectrode Geometry for Comprehensive Detection of Individual Exocytosis Events at Single Cells

De Alwis, A. C., Denison, J. D., Shah, R., McCarty, G. S., & Sombers, L. A. (2023, August 8). ACS SENSORS, Vol. 8.

By: A. De Alwis n, J. Denison n, R. Shah  n, G. McCarty n  & L. Sombers n 

author keywords: voltammetry; amperometry; chromaffincell; diffusion; catecholamine; dense corevesicle; carbon fiber microelectrode
TL;DR: This work demonstrates how electrode geometry can be exploited for improved detection of exocytosis events by addressing diffusional loss─an often-overlooked source of inaccuracy in single-cell measurements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 21, 2023

2023 journal article

Exploring Electrochemistry: A Hydrogen Peroxide Sensor Based on a Screen-Printed Carbon Electrode Modified with Prussian Blue

JOURNAL OF CHEMICAL EDUCATION, 100(12), 4853–4859.

By: J. Todorov n, G. McCarty n  & L. Sombers n 

author keywords: Upper-Division Undergraduate; AnalyticalChemistry; Laboratory Equipment; Hands-On Learning; Electrochemistry; Quantitative Analysis
Sources: Web Of Science, ORCID
Added: January 8, 2024

2023 journal article

Simultaneous, Real-Time Detection of Glutamate and Dopamine in Rat Striatum Using Fast-Scan Cyclic Voltammetry

ACS SENSORS, 8(11), 4091–4100.

By: L. Kimble n, J. Twiddy n, J. Berger n, A. Forderhase n, G. Mccarty n , J. Meitzen n , L. Sombers n 

author keywords: FSCV; biosensor; carbon-fiber microelectrode; excitatory amino acid transporter; dl-threo-beta-benzyloxyaspartic acid; dl-TBOA
TL;DR: A novel glutamate microbiosensor fabricated on a carbon-fiber microelectrode substrate and coupled with fast-scan cyclic voltammetry (FSCV) to enable the simultaneous quantification of glutamate and DA at single recording sites in the brain, which is impossible when using typical amperometric approaches. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: December 18, 2023

2023 journal article

Untapped Potential: Real-Time Measurements of Opioid Exocytosis at Single Cells

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(44), 24071–24080.

By: J. Denison n, A. De Alwis n, R. Shah  n, G. Mccarty n  & L. Sombers n 

TL;DR: Comparing the results collected at the two potentials reveals unique kinetics for these two neurochemical classes at the single-vesicle level, providing unprecedented insight into key differences between catecholamine and opioid neuropeptide release from isolated chromaffin cells. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: December 11, 2023

2022 article

Neurotransmitter Readily Escapes Detection at the Opposing Microelectrode Surface in Typical Amperometric Measurements of Exocytosis at Single Cells

McCarty, G. S., Dunaway, L. E., Denison, J. D., & Sombers, L. A. (2022, June 24). ANALYTICAL CHEMISTRY, Vol. 6.

By: G. McCarty n , L. Dunaway n, J. Denison n & L. Sombers n 

MeSH headings : Animals; Carbon Fiber; Catecholamines / metabolism; Cattle; Chromaffin Cells / metabolism; Exocytosis / physiology; Microelectrodes; Neurotransmitter Agents / metabolism
TL;DR: This study characterizes distinct physical and biological mechanisms by which released neurotransmitter escapes detection at the opposing microelectrode surface, while also revealing an important role for the NET in “presynaptic” modulation of neurotransmitter release. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 18, 2022

2020 journal article

Interpreting Dynamic Interfacial Changes at Carbon Fiber Microelectrodes Using Electrochemical Impedance Spectroscopy

Langmuir, 36(15), 4214–4223.

By: C. Meunier n, J. Denison n, G. McCarty n  & L. Sombers n 

MeSH headings : Carbon; Carbon Fiber; Dielectric Spectroscopy; Electric Impedance; Microelectrodes
TL;DR: Electrochemical impedance spectroscopy is established as a powerful method for characterization of carbon-fiber microelectrodes, providing unprecedented insight into how real-world factors affect the electrode/solution interface. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: May 8, 2020

2019 journal article

Drift Subtraction for Fast-Scan Cyclic Voltammetry Using Double-Waveform Partial-Least-Squares Regression

Analytical Chemistry, 91(11), 7319–7327.

By: C. Meunier n, G. McCarty n  & L. Sombers n 

MeSH headings : Adenosine / analysis; Animals; Brain / diagnostic imaging; Dopamine / analysis; Electrochemical Techniques; Hydrogen Peroxide / analysis; Least-Squares Analysis; Male; Rats; Rats, Sprague-Dawley
TL;DR: DW-PLSR is used to improve quantification of adenosine, dopamine, and hydrogen peroxide fluctuations occurring >10 min from the initial background position, both in vitro and in vivo, and is demonstrated to be a powerful tool for evaluating and interpreting both rapid and gradual chemical changes captured in FSCV recordings over extended durations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: June 24, 2019

2018 journal article

Carbon-Fiber Microbiosensor for Monitoring Rapid Lactate Fluctuations in Brain Tissue Using Fast-Scan Cyclic Voltammetry

Analytical Chemistry, 90(21), 12994–12999.

By: S. Smith n, S. Gosrani n, C. Lee n, G. McCarty n  & L. Sombers n 

MeSH headings : Animals; Biosensing Techniques / methods; Carbon Fiber / chemistry; Electrochemical Techniques / instrumentation; Electrochemical Techniques / methods; Enzymes, Immobilized / chemistry; Lactic Acid / analysis; Limit of Detection; Male; Microelectrodes; Mixed Function Oxygenases / chemistry; Neostriatum / metabolism; Rats, Sprague-Dawley; Sensitivity and Specificity
TL;DR: There is evidence that striatal lactate availability increases biphasically in response to electrical stimulation of the dopaminergic midbrain in the anesthetized rat, and this new tool for real-time detection of lactate dynamics promises to improve understanding of how lactateavailability underscores neuronal function and dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: November 26, 2018

2018 journal article

Characterization of a Multiple-Scan-Rate Voltammetric Waveform for Real-Time Detection of Met-Enkephalin

ACS Chemical Neuroscience, 10(4), 2022–2032.

By: S. Calhoun n, C. Meunier n, C. Lee n, G. McCarty n  & L. Sombers n 

author keywords: carbon fiber; opioid; chromaffin cell; dopamine; cyclic voltammetry; microelectrode; FSCV
MeSH headings : Adrenal Glands / chemistry; Adrenal Glands / metabolism; Animals; Electrochemical Techniques / methods; Enkephalin, Methionine / analysis; Enkephalin, Methionine / metabolism; Male; Microinjections / methods; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Substantia Nigra / chemistry; Substantia Nigra / metabolism
TL;DR: This work evaluated the waveform parameters to increase sensitivity to methionine-enkephalin (M-ENK), an endogenous opioid neuropeptide implicated in pain, stress, and reward circuits and demonstrates how voltammetric waveforms can be customized to enhance detection of specific target analytes, broadly speaking. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: May 6, 2019

2018 journal article

Electrochemical Selectivity Achieved Using a Double Voltammetric Waveform and Partial Least Squares Regression: Differentiating Endogenous Hydrogen Peroxide Fluctuations from Shifts in pH

Analytical Chemistry, 90(3), 1767–1776.

By: C. Meunier n, E. Mitchell n, J. Roberts n, J. Toups n, G. McCarty n  & L. Sombers n 

MeSH headings : Animals; Brain / metabolism; Electrochemical Techniques / methods; Hydrogen Peroxide / metabolism; Hydrogen-Ion Concentration; Least-Squares Analysis; Male; Principal Component Analysis; Rats, Sprague-Dawley
TL;DR: The data demonstrate that the double waveform PLSR model is a powerful tool that can be used to disambiguate and evaluate naturally occurring H2O2 fluctuations in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID
Added: February 5, 2020

2018 journal article

Quantitative Comparison of Enzyme Immobilization Strategies for Glucose Biosensing in Real-Time Using Fast-Scan Cyclic Voltammetry Coupled with Carbon-Fiber Microelectrodes

ChemPhysChem, 19(10), 1197–1204.

By: S. Smith n, L. Lugo-Morales n, C. Tang  n, S. Gosrani n, C. Lee n, J. Roberts n, S. Morton n, G. McCarty n , S. Khan n , L. Sombers n 

author keywords: biosensing; carbon-fiber microelectrodes; cyclic voltammetry; dopamine; glucose
MeSH headings : Animals; Biosensing Techniques; Carbon / chemistry; Electrochemical Techniques; Enzymes, Immobilized; Glucose / analysis; Glucose Oxidase / metabolism; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Time Factors
TL;DR: Comparing three approaches to enzyme immobilization on the microelectrode surface-physical adsorption, hydrogel entrapment, andEntrapment in electrospun nanofibers suggests that each of these methods can be used to create functional microbiosensors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID
Added: January 25, 2020

2017 journal article

Background Signal as an in Situ Predictor of Dopamine Oxidation Potential: Improving Interpretation of Fast-Scan Cyclic Voltammetry Data

ACS CHEMICAL NEUROSCIENCE, 8(2), 411–419.

By: C. Meunier n, J. Roberts n, G. McCarty n  & L. Sombers n 

author keywords: Carbon-fiber microelectrode; electrochemical impedance spectroscopy; electrochemistry; calibration; in vivo
MeSH headings : Analysis of Variance; Animals; Antipsychotic Agents / pharmacology; Biophysics; Brain / drug effects; Brain / metabolism; Dopamine / metabolism; Electric Stimulation; Electrochemical Techniques; Electrodes; Enzyme Inhibitors / pharmacology; Male; Neural Pathways / drug effects; Neural Pathways / metabolism; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reserpine / pharmacology; alpha-Methyltyrosine / pharmacology
TL;DR: The model, validated both in adrenal slice and live brain tissue, enables information encoded in the shape of the background voltammogram to determine electrochemical parameters that are critical for accurate quantification, which improves data interpretation and provides a significant next step toward more automated methods for in vivo data analysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum

ACS Chemical Neuroscience, 8(2), 272–280.

By: S. Smith n, C. Lee n, M. Dausch n, B. Horman n, H. Patisaul n , G. McCarty n , L. Sombers n 

author keywords: Biosensor; carbon fiber microelectrode; neuroenergetics; glucose oxidase; cocaine; fast-scan cyclic voltammetry
MeSH headings : Animals; Biophysics; Cocaine / pharmacology; Corpus Striatum / cytology; Corpus Striatum / diagnostic imaging; Corpus Striatum / drug effects; Corpus Striatum / metabolism; Dopamine / metabolism; Dopamine Antagonists / pharmacology; Dopamine Uptake Inhibitors / pharmacology; Drug Combinations; Electric Stimulation; Extracellular Fluid / metabolism; Glial Fibrillary Acidic Protein / metabolism; Glucose / metabolism; Hydrogen Peroxide / metabolism; Male; Microelectrodes; Raclopride / pharmacology; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase / metabolism
TL;DR: This work evaluates several waveforms to enable the first simultaneous detection of endogenous glucose and dopamine at single recording sites, and directly demonstrates the coupling of glucose availability with increased metabolic demand. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Spectroelectrochemical Characterization of the Dynamic Carbon-Fiber Surface in Response to Electrochemical Conditioning

Langmuir, 33(32), 7838–7846.

By: E. Mitchell n, L. Dunaway n, G. McCarty n  & L. Sombers n 

TL;DR: The data demonstrate that the carbon-fiber microstructure is dynamic, able to quickly and continuously undergo rapid structural reorganization as potential is applied, repeatedly alternating between a relatively ordered state and one that exhibits greater disorder in response to applied electrochemical potentials that span the range commonly used in voltammetric experiments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Design and characterization of a microfabricated hydrogen clearance blood flow sensor

JOURNAL OF NEUROSCIENCE METHODS, 267, 132–140.

By: L. Walton *, M. Edwards *, G. McCarty n  & R. Wightman *

author keywords: COMSOL Multiphysics; Electrolysis; Gas clearance; Photolithography; Platinum electrode
MeSH headings : Blood Chemical Analysis / instrumentation; Cerebrovascular Circulation / physiology; Computer Simulation; Electrodes, Implanted; Equipment Design; Finite Element Analysis; Hydrogen / analysis; Microtechnology; Norepinephrine / metabolism; Oxygen / analysis; Platinum; Reproducibility of Results
TL;DR: Microfabrication allows for the high-throughput production of reproducible devices that are capable of monitoring deep brain CBF with sub-minute resolution, and can resolve physiological changes occurring on a shorter timescale than existing gas clearance measurements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Facilitating Teamwork in Adolescent and Young Adult Oncology

JOURNAL OF ONCOLOGY PRACTICE, 12(11), 1067-+.

By: R. Johnson*, C. Macpherson*, A. Smith *, R. Block * & J. Keyton *

MeSH headings : Adolescent; Adult; Communication; Cooperative Behavior; Humans; Interprofessional Relations; Male; Patient Care Team / organization & administration; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Trust; Young Adult
TL;DR: A case of a young adult patient in the days immediately after a cancer diagnosis illustrates the critical importance of three interrelated core coordinating mechanisms-closed-loop communication, shared mental models, and mutual trust-of teamwork in an adolescent and young adult multidisciplinary oncology team. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Microfabricated Collector-Generator Electrode Sensor for Measuring Absolute pH and Oxygen Concentrations

ANALYTICAL CHEMISTRY, 87(20), 10556–10564.

By: A. Dengler n, R. Wightman * & G. McCarty n 

MeSH headings : Electrochemical Techniques / instrumentation; Hydrogen-Ion Concentration; Microelectrodes; Oxygen / analysis
TL;DR: A microfabricated microelectrode array which uses FSCV to detect the absolute levels of oxygen and pH in vitro and a periodic potential step is applied at the generator producing transient local changes in the electrochemical environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Multiple Scan Rate Voltammetry for Selective Quantification of Real-Time Enkephalin Dynamics

ANALYTICAL CHEMISTRY, 86(15), 7806–7812.

By: A. Schmidt n, L. Dunaway n, J. Roberts n, G. McCarty n  & L. Sombers n 

MeSH headings : Animals; Electrodes; Enkephalins / physiology; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley
TL;DR: This work has developed and characterized a novel voltammetric waveform for the selective quantification of small tyrosine-containing peptides, such as the ENKs, with rapid temporal (subsecond) and precise spatial (10s of micrometers) resolution, and provides a foundation for real-time measurements of endogenous ENK fluctuations in biological locations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Reducing the Sampling Rate of Biochemical Measurements Using Fast-Scan Cyclic Voltammetry for In Vivo Applications

IEEE SENSORS JOURNAL, 14(9), 2975–2980.

By: A. Amos n, J. Roberts n, L. Qi n, L. Sombers n  & G. McCarty n 

author keywords: Carbon fiber microelectrodes; dopamine; electrochemistry; wireless protocol
TL;DR: Reducing the sampling rate of a proven in vivo measurement technology, fast-scan cyclic voltammetry at carbon-fiber microelectrodes, reduces the quantity of data generated by an order of magnitude compared with the existing protocol and with duty cycling is expected to decrease power consumption by a similar value in wireless systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

In Situ Electrode Calibration Strategy for Voltammetric Measurements In Vivo

ANALYTICAL CHEMISTRY, 85(23), 11568–11575.

By: J. Roberts n, J. Toups n, E. Eyualem n, G. McCarty n  & L. Sombers n 

MeSH headings : Animals; Calibration; Electrochemical Techniques / methods; Electrodes, Implanted; Flow Injection Analysis / methods; Male; Rats; Rats, Sprague-Dawley
TL;DR: A model that utilizes information contained in the background charging current to predict electrode sensitivity to dopamine, ascorbic acid, hydrogen peroxide, and pH shifts at any point in an electrochemical experiment is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Microfabricated microelectrode sensor for measuring background and slowly changing dopamine concentrations

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 693, 28–33.

By: A. Dengler n & G. McCarty n 

author keywords: Dopamine; Tonic level; Electrochemical measurement; Basal level; Biochemical sensor; Microfabricated sensor
TL;DR: A microfabricated electrochemical sensor for measuring background and slowly changing concentrations of DA in vitro with the selectivity and sensitivity of FSCV is presented and the background of DA is determined in vitro using this sensor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Carbon Microelectrodes with a Renewable Surface

ANALYTICAL CHEMISTRY, 82(5), 2020–2028.

By: P. Takmakov  n, M. Zachek n, R. Keithley  n, P. Walsh n, C. Donley  n, G. McCarty n , R. Wightman  n

MeSH headings : Carbon / chemistry; Microelectrodes; Microscopy, Atomic Force; Surface Properties
TL;DR: An electrochemical procedure that constantly renews the surface of a carbon microelectrode using periodic triangle voltage excursions to an extended anodic potential at a scan rate of 400 V s(-1) allows for the regeneration of an electrochemically active surface and restores electrode sensitivity degraded by irreversible adsorption of chemical species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Characterization of Local pH Changes in Brain Using Fast-Scan Cyclic Voltammetry with Carbon Microelectrodes

ANALYTICAL CHEMISTRY, 82(23), 9892–9900.

By: P. Takmakov  n, M. Zachek n, R. Keithley  n, E. Bucher n, G. McCarty n  & R. Wightman n

MeSH headings : 3,4-Dihydroxyphenylacetic Acid / chemistry; Animals; Brain / metabolism; Carbon / chemistry; Electrochemical Techniques / methods; Flow Injection Analysis; Hydrogen-Ion Concentration; Male; Microelectrodes; Rats; Rats, Sprague-Dawley
TL;DR: Hypercapnia is demonstrated to be a useful tool to induce robust in vivo pH changes, allowing confirmation of the pH signal observed with FSCV and an extra peak relating to the capacitive nature ofthe pH CV was identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Enhancing electrochemical detection by scaling solid state nanogaps

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 643(1-2), 9–14.

By: G. McCarty n , B. Moody n & M. Zachek n

author keywords: Dopamine; Nanogaps; CV; Nanoscale electrochemistry; Electrochemical cycling
TL;DR: The results show a several order of magnitude enhancement of the electrochemical signal, collected current, for the solid state nanogaps with 6 nm electrode-electrode spacings as compared to traditional microelectrodes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

In Situ Monitoring of Adipogenesis with Human-Adipose-Derived Stem Cells Using Surface-Enhanced Raman Spectroscopy

APPLIED SPECTROSCOPY, 64(11), 1227–1233.

By: B. Moody n, C. Haslauer n, E. Kirk n, A. Kannan n, E. Loboa n & G. McCarty n 

author keywords: Raman spectroscopy; Adipogenesis; Stem cells; Surface-enhanced Raman spectroscopy; SERS
MeSH headings : Adipogenesis / physiology; Adipose Tissue / cytology; Adipose Tissue / metabolism; Adult; Cells, Cultured; Endocytosis; Female; Gold Colloid / chemistry; Gold Colloid / pharmacokinetics; Humans; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; Spectrum Analysis, Raman / methods; Stem Cells / cytology; Stem Cells / metabolism
TL;DR: It is shown that intracellular SERS is able to detect the production of lipids as little as one day after the onset of adipogenesis and that a complex interplay between lipids, proteins, and chemical messengers can be observed shortly thereafter. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Microfabricated FSCV-compatible microelectrode array for real-time monitoring of heterogeneous dopamine release

The Analyst, 135(7), 1556.

By: M. Zachek*, J. Park *, P. Takmakov *, R. Wightman * & G. McCarty* 

MeSH headings : Dopamine / metabolism; Electrochemical Techniques / instrumentation; Electrochemical Techniques / methods; Microelectrodes; Time Factors
TL;DR: Heterogeneous release of electrically evoked dopamine was observed in real-time in the striatum of an anesthetized rat using the FSCV-MEA, which allows for better reproducibility than traditional fabrication methods of carbon fiber microelectrodes, and enable batch fabrication of electrode arrays. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Simultaneous monitoring of dopamine concentration at spatially different brain locations in vivo

Biosensors and Bioelectronics, 25(5), 1179–1185.

By: M. Zachek*, P. Takmakov *, J. Park *, R. Wightman* & G. McCarty* 

author keywords: Dopamine; Microelectrodes; Electrode arrays; In vivo electrochemistry; FSCV
MeSH headings : Animals; Biosensing Techniques / instrumentation; Corpus Striatum / metabolism; Dopamine / analysis; Electrochemistry / instrumentation; Electrodes, Implanted; Equipment Design; Equipment Failure Analysis; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution
TL;DR: This work presents one of the first FSCV microelectrode arrays (MEA) implemented in vivo with the ability to sample from different regions in close spatial proximity (equidistant within 1mm), manufactured from fused silica capillaries and a microfabricated electrode spacer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID
Added: February 5, 2020

2010 journal article

Specific Oxygen-Containing Functional Groups on the Carbon Surface Underlie an Enhanced Sensitivity to Dopamine at Electrochemically Pretreated Carbon Fiber Microelectrodes

LANGMUIR, 26(11), 9116–9122.

By: J. Roberts n, B. Moody n, G. McCarty n  & L. Sombers n 

MeSH headings : Carbon / chemistry; Dopamine / chemistry; Electrochemistry / instrumentation; Microelectrodes; Microscopy, Atomic Force; Oxygen / chemistry; Spectrum Analysis, Raman
TL;DR: It is demonstrated that this electrochemical pretreatment can be used to create carbon microdisc electrodes with sensitivities comparable to those associated with larger, conventionally treated cylindrical carbon fiber microelectrodes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Simultaneous Decoupled Detection of Dopamine and Oxygen Using Pyrolyzed Carbon Microarrays and Fast-Scan Cyclic Voltammetry

ANALYTICAL CHEMISTRY, 81(15), 6258–6265.

By: M. Zachek n, P. Takmakov  n, B. Moody n, R. Wightman  n & G. McCarty n 

MeSH headings : Animals; Biosensing Techniques; Brain / metabolism; Carbon / chemistry; Dopamine / analysis; Electrochemistry / instrumentation; Microarray Analysis; Microelectrodes; Oxygen / analysis; Rats; Spectrum Analysis, Raman
TL;DR: The work described in this paper utilizes microfabrication processes to produce devices that enable multiple fast-scan cyclic voltammetry (FSCV) waveforms to be applied to different electrodes on a single substrate, enabling the simultaneous, decoupled detection of dopamine and oxygen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Solid state nanogaps for differential measurements of molecular properties

Applied Physics Letters, 94(12), 122104.

By: B. Moody n & G. McCarty n 

author keywords: nanostructured materials; organic compounds; Raman spectra
TL;DR: This paper demonstrates the production and probing of solid state nanogaps by using surface enhanced Raman spectroscopy to collect molecular information at the nanogap and current-voltage traces to probe the charge transport of thenanogap. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Statistically Significant Raman Detection of Midsequence Single Nucleotide Polymorphisms

ANALYTICAL CHEMISTRY, 81(5), 2013–2016.

By: B. Moody n & G. McCarty n 

MeSH headings : Biosensing Techniques / methods; DNA / chemistry; Oligonucleotides / chemistry; Polymorphism, Single Nucleotide / genetics; Spectrum Analysis, Raman / methods; Surface Plasmon Resonance / methods; Surface Properties
TL;DR: This report highlights methodologies that enable statistically significant data to be collected for single nucleotide polymorphisms using surface enhanced Raman spectroscopy and shows that statistically significant differences in Raman intensity for characteristic peaks can be collected. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Electrochemical dopamine detection: Comparing gold and carbon fiber microelectrodes using background subtracted fast scan cyclic voltammetry

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 614(1-2), 113–120.

By: M. Zachek n, A. Hermans*, R. Wightman* & G. McCarty n 

author keywords: dopamine; carbon fiber microelectrode; Au microelectrode
TL;DR: Dopamine detection on gold microelectrodes was characterized and compared to P-55 carbon fiber micro electrodes of the same geometry, using background subtracted fast scan cyclic voltammetry, and selectivity to dopamine, in comparison to several other neurotransmitters and their derivatives, is described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Effects of Molecular Structure and Interfacial Ligation on the Precision of Cu-Bound α,ω-Mercaptoalkanoic Acid “Molecular Ruler” Stacks

Langmuir, 23(2), 638–648.

By: T. Daniel *, S. Uppili*, G. McCarty*  & D. Allara*

Sources: Crossref, ORCID
Added: February 5, 2020

2006 journal article

Hybrid Approaches to Nanolithography: Photolithographic Structures with Precise, Controllable Nanometer-Scale Spacings Created by Molecular Rulers

Advanced Materials, 18(8), 1020–1022.

By: M. Anderson *, M. Mihok*, H. Tanaka *, L. Tan*, M. Horn*, G. McCarty n , P. Weiss *

Sources: Crossref, ORCID
Added: February 5, 2020

2006 journal article

Monitoring the addition of molecular species to electrodes utilizing inherent electronic properties

Journal of Applied Physics, 99(6), 064701.

By: G. McCarty n 

TL;DR: Electro pairs featuring nanometer scale junctions are utilized to detect the addition of an amino acid to nanogap sensors through variations in their electronic properties, which has the potential of offering a powerful, nonoptical alternative for biological monitoring in extremely small volumes and of extremely low concentrations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Formation and Manipulation of Protopolymer Chains

Journal of the American Chemical Society, 126(51), 16772–16776.

By: G. McCarty*  & P. Weiss *

TL;DR: It is demonstrated that protopolyphenylene forms by manipulating individual monomer units out of the chains using a scanning tunneling microscope, and that the alignment due to these interactions may be used in the controlled growth and assembly, as well as for the simplified manipulation of complex, hierarchical structures. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 5, 2020

2004 journal article

Molecular Lithography for Wafer-Scale Fabrication of Molecular Junctions

Nano Letters, 4(8), 1391–1394.

By: G. McCarty* 

Sources: Crossref, ORCID
Added: February 5, 2020

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