Works (36)
Updated: August 16th, 2024 13:38
2023 journal article
Cellulose Acetate-Stabilized Pickering Emulsions: Preparation, Rheology, and Incorporation of Agricultural Active Ingredients
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 11(42), 15178–15191.
author keywords: nonsporulating microbes; double yielding; Pseudomonas simiae; microstructure; controlledrelease
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 1, 2023
2022 article
Wrap-and-plant technology to manage sustainably potato cyst nematodes in East Africa
Ochola, J., Cortada, L., Mwaura, O., Tariku, M., Christensen, S. A., Ng'ang'a, M., … Torto, B. (2022, February 28). NATURE SUSTAINABILITY, Vol. 2.
open access via www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 1, 2022
2019 journal article
Near-Atomic-Resolution Cryo-Electron Microscopy Structures of Cucumber Leaf Spot Virus and Red Clover Necrotic Mosaic Virus: Evolutionary Divergence at the Icosahedral Three-Fold Axes
JOURNAL OF VIROLOGY, 94(2).
Contributors: M. Sherman *, R. Guenther n, R. Reade *, R. D’Ann*, T. Sit n & T. Smitha
Ed(s): C. Parrish
author keywords: Tombusviridae; electron microscopy; plant viruses; virion structure
MeSH headings : Capsid / ultrastructure; Capsid Proteins / ultrastructure; Cryoelectron Microscopy; Evolution, Molecular; Tobacco; Tombusviridae / ultrastructure
TL;DR:
It appears that the ssRNA binding (R) domain of the capsid diverged evolutionarily in order to recognize the different genomes, and the R and arm domains may have coevolved to package different genomes within the conserved and rigid shell.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 21, 2020
2018 article
Plant Virus-Based Nanoparticles for the Delivery of Agronomic Compounds as a Suspension Concentrate
VIRUS-DERIVED NANOPARTICLES FOR ADVANCED TECHNOLOGIES: METHODS AND PROTOCOLS, Vol. 1776, pp. 203–214.
Contributors: R. Guenther n, S. Lommel n, C. Opperman n & T. Sit n
author keywords: Plant pathogenic nematode; Nematicide; Agrichemical; Plant viral nanoparticle; Nanoparticle formulation
MeSH headings : Ivermectin / analogs & derivatives; Ivermectin / chemistry; Nanoparticles / chemistry; Plant Viruses / chemistry; Tombusviridae / chemistry
TL;DR:
This work describes how to formulate a PVN loaded with the nematicide abamectin (Abm) beginning with the propagation of the virus through the formulation, deactivation, and characterization of the finished product.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 14, 2019
2015 journal article
Development of abamectin loaded lignocellulosic matrices for the controlled release of nematicide for crop protection
CELLULOSE, 23(1), 673–687.
Contributors: J. Cao n, R. Guenther n, T. Sit n , S. Lommel n, C. Opperman n & J. Willoughby n
author keywords: Lignocellulosic matrix; Controlled release; Abamectin; Lignin; Crop protection
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Loading and Release Mechanism of Red Clover Necrotic Mosaic Virus Derived Plant Viral Nanoparticles for Drug Delivery of Doxorubicin
SMALL, 10(24), 5126–5136.
Contributors: J. Cao n, R. Guenther n, T. Sit n , C. Opperman n, S. Lommel n & J. Willoughby n
MeSH headings : Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / pharmacokinetics; Capsid; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Carriers; Hydrogen-Ion Concentration; Nanoparticles; Tombusviridae / chemistry
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
New insight into the structure of RNA in red clover necrotic mosaic virus and the role of divalent cations revealed by small-angle neutron scattering
ARCHIVES OF VIROLOGY, 158(8), 1661–1669.
Contributors: S. Martin n, L. He *, F. Meilleur n , R. Guenther n, T. Sit n , S. Lommel n, W. Heller *
TL;DR:
Small-angle neutron scattering with contrast variation experiments were performed to better understand the organization of the RNA and conformational changes resulting from the removal of divalent cations in red clover necrotic mosaic virus and provide new insight into changes in the RNA packing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Polymeric Systems Incorporating Plant Viral Nanoparticles for Tailored Release of Therapeutics
ADVANCED HEALTHCARE MATERIALS, 2(7), 1001–1007.
author keywords: controlled release; drug delivery; nanofibers; plant viral nanoparticles; virus
MeSH headings : Antineoplastic Agents / administration & dosage; Doxorubicin / administration & dosage; Drug Carriers; Kinetics; Nanoparticles; Plant Viruses; Polymers
TL;DR:
Kinetic analysis results suggest a two‐phase release profile with the first phase following a hindered Fickian transport mechanism for the release of Dox for the polymer‐embedded PVNs and the nanofiber matrices that incorporate PVNs through the immersion processing method followed a pseudo‐first order kinetic transport mechanism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 article
Functional Recognition of the Modified Human tRNA (Lys3) (UUU) Anticodon Domain by HIV's Nucleocapsid Protein and a Peptide Mimic (vol 410, pg 698, year 2011)
Journal of Molecular Biology, Vol. 420, pp. 259–259.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Functional recognition of the modified human tRNA(UUU)(Lys3) anticodon domain by HIV's nucleocapsid protein and a peptide mimic
Journal of Molecular Biology, 410(4), 698–715.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Crystallization and preliminary X-ray diffraction analysis of red clover necrotic mosaic virus
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 66(Pt 11), 1458–1462.
author keywords: red clover necrotic mosaic virus; dianthoviruses; viruses
MeSH headings : Crystallization; Crystallography, X-Ray; Microscopy, Electron, Transmission; Tombusviridae / chemistry; Tombusviridae / ultrastructure; Virion / chemistry; Virion / ultrastructure
TL;DR:
Red clover necrotic mosaic virus is a species that belongs to the Tombusviridae family of plant viruses with a T = 3 icosahedral capsid and crystals diffracted to better than 4 Å resolution but were very radiation-sensitive, causing rapid decay of the high-resolution reflections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2009 journal article
The structure of the human tRNA(Lys3) anticodon bound to the HIV genome is stabilized by modified nucleosides and adjacent mismatch base pairs
NUCLEIC ACIDS RESEARCH, 37(10), 3342–3353.
MeSH headings : Anticodon / chemistry; Base Pair Mismatch; Base Sequence; Carbohydrates / chemistry; Genome, Viral; HIV-1 / genetics; Humans; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protons; Pseudouridine / chemistry; RNA, Transfer, Lys / chemistry; RNA, Viral / chemistry; Thermodynamics; Thiouridine / analogs & derivatives; Thiouridine / chemistry
TL;DR:
The thermal stabilities of variously modified tRNA anticodon region sequences bound to the Loop I of viral sub(sero)types G and B were analyzed and the structure of one duplex containing two modified nucleosides was determined using NMR spectroscopy and restrained molecular dynamics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Infusion of dye molecules into Red clover necrotic mosaic virus
CHEMICAL COMMUNICATIONS, (1), 88–90.
MeSH headings : Capsid Proteins / chemistry; Capsid Proteins / metabolism; Coloring Agents / analysis; Coloring Agents / metabolism; Doxorubicin / metabolism; Microscopy, Electron, Transmission; Tombusviridae / chemistry; Tombusviridae / metabolism; Tombusviridae / ultrastructure
TL;DR:
The Red clover necrotic mosaic virus capsid is utilized to package and release molecules through reversible depletion and re-addition of divalent cations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Controlled encapsidation of gold nanoparticles by a viral protein shell
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(14), 4502–4503.
MeSH headings : Capsid Proteins / chemistry; Capsid Proteins / genetics; DNA, Viral / chemistry; DNA, Viral / genetics; Gold / chemistry; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; RNA, Viral / chemistry; RNA, Viral / genetics; Tombusviridae / chemistry; Tombusviridae / genetics
TL;DR:
Covalent linkage of the OAS to Au functions as a trigger for specific encapsidation and demonstrates that foreign cargo can be packaged into Red clover necrotic mosaic virus virions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Removal of divalent cations induces structural transitions in Red clover necrotic mosaic virus, revealing a potential mechanism for RNA release
JOURNAL OF VIROLOGY, 80(21), 10395–10406.
Contributors: M. Sherman n, R. Guenther n, F. Tama *, T. Sit n , C. Brooks *, A. Mikhailov*, E. Orlova *, T. Baker n, S. Lommel n
MeSH headings : Amino Acid Sequence; Calcium / metabolism; Capsid / metabolism; Capsid / ultrastructure; Capsid Proteins / genetics; Capsid Proteins / metabolism; Capsid Proteins / ultrastructure; Cations, Divalent / metabolism; Cryoelectron Microscopy; Image Processing, Computer-Assisted; Magnesium / metabolism; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; RNA, Viral / genetics; RNA, Viral / metabolism; Sequence Homology, Amino Acid; Species Specificity; Static Electricity; Tombusviridae / genetics; Tombusviridae / metabolism; Tombusviridae / ultrastructure
TL;DR:
Results indicate that divalent cations play a central role in capsid dynamics and suggest a mechanism for the release of viral RNA in low-divalent-cation environments such as those found within the cytoplasm of a cell.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Structural characterization of an intermolecular RNA-RNA interaction involved in the transcription regulation element of a bipartite plant virus
NUCLEIC ACIDS RESEARCH, 32(9), 2819–2828.
MeSH headings : Base Pairing; Base Sequence; Computer Simulation; Gene Expression Regulation, Viral; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Promoter Regions, Genetic; RNA, Viral / chemistry; RNA, Viral / metabolism; Regulatory Sequences, Ribonucleic Acid; Tombusviridae / genetics; Transcription, Genetic
TL;DR:
The RCNMV TA structural model is similar to those for the Simian retrovirus frameshifting element and the Human immunodeficiency virus-1 dimerization kissing hairpins, suggesting a conservation of form and function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Naturally-occurring modification restricts the anticodon domain conformational space of tRNA(Phe)
JOURNAL OF MOLECULAR BIOLOGY, 334(5), 901–918.
author keywords: methylation; anticodon dynamics; tRNA position 37; codon recognition; frameshifting
MeSH headings : Anticodon; Base Sequence; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; RNA, Transfer, Phe / chemistry
TL;DR:
A comparison of the resulting structures indicates that modification of position 37 affects the accuracy of decoding and the maintenance of the mRNA reading frame by restricting anticodon loop conformational space.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Accurate translation of the genetic code depends on tRNA modified nucleosides
JOURNAL OF BIOLOGICAL CHEMISTRY, 277(19), 16391–16395.
MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Asparagine / chemistry; Base Pairing; Base Sequence; Codon; Genetic Code; Molecular Sequence Data; Nucleic Acid Conformation; Nucleosides / metabolism; Protein Biosynthesis; Protein Structure, Tertiary; RNA / metabolism; RNA, Messenger / metabolism; RNA, Ribosomal, 16S / metabolism; RNA, Transfer / metabolism; Ribosomes / metabolism; Thiouridine / analogs & derivatives; Thiouridine / chemistry; Uridine / analogs & derivatives; Uridine / chemistry
TL;DR:
It is concluded that modified nucleosides evolved to modulate an anticodon domain structure necessary for many tRNA species to accurately translate the genetic code.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Highly conserved modified nucleosides influence Mg2+-dependent tRNA folding
NUCLEIC ACIDS RESEARCH, 30(21), 4751–4760.
MeSH headings : Base Sequence; Electrophoretic Mobility Shift Assay; Hydrogen Bonding; Lead / pharmacology; Magnesium / pharmacology; Models, Molecular; Nucleic Acid Conformation / drug effects; Nucleosides / chemistry; Nucleosides / metabolism; RNA Stability / drug effects; RNA, Fungal / chemistry; RNA, Fungal / genetics; RNA, Fungal / metabolism; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Ribonuclease T1 / metabolism; Thermodynamics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Interaction of RNA with phage display selected peptides analyzed by capillary electrophoresis mobility shift assay
RNA, 8(5), 698–704.
author keywords: anticodon stem and loop; capillary electrophoresis; methylated nucleoside-dependent RNA-peptide; interaction; phage display selected peptides; tRNA
MeSH headings : Amino Acid Sequence; Anticodon / chemistry; Anticodon / genetics; Anticodon / metabolism; Base Sequence; Electrophoresis, Capillary / methods; In Vitro Techniques; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Library; Peptides / chemistry; Peptides / metabolism; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism
TL;DR:
Capillary electrophoresis was found to be an efficient and sensitive method for the qualitative analysis of RNA/peptide interaction and should be generally applicable to the study of RNA- peptide (protein) interactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Functional anticodon architecture of human tRNA(Lys3) includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t(6)A
BIOCHEMISTRY, 39(44), 13396–13404.
MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Adenosine / metabolism; Amino Acid Substitution; Anticodon / chemical synthesis; Anticodon / chemistry; Crystallography, X-Ray; Humans; Hydrogen Bonding; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular / methods; Nucleic Acid Conformation; Protein Binding; Pseudouridine / chemistry; RNA, Transfer, Lys / chemical synthesis; RNA, Transfer, Lys / chemistry; Ribosomal Proteins / chemistry; Thermodynamics; Threonine / chemistry; Threonine / metabolism
TL;DR:
From these results, it is concluded that ribosome binding cannot simply be an induced fit of the anticodon stem and loop, otherwise the unmodified ASL(Lys3)(UUU) would bind as well as ASL (Lys 3)(UU U)-t(6)A(37), and the ionized carboxylic acid moiety of t(6), possibly neutralizes the positive charge of A(+)(38).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Modified constructs of the tRNA T Psi C domain to probe substrate conformational requirements of m(1)A(58) and m(5)U(54) tRNA methyltransferases
NUCLEIC ACIDS RESEARCH, 28(6), 1374–1380.
MeSH headings : Animals; Escherichia coli / enzymology; Kinetics; Magnetic Resonance Spectroscopy; Methylation; Nucleic Acid Conformation; Nucleosides / chemistry; Nucleosides / genetics; Nucleosides / metabolism; RNA Stability; RNA, Transfer, Phe / chemical synthesis; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Substrate Specificity; Temperature; Tetrahymena pyriformis / enzymology; Thermodynamics; Yeasts / genetics; tRNA Methyltransferases / metabolism
TL;DR:
It is reported that RAMT can recognize and methylate a TSL heptadecamer, and local conformation around U(54) was found to be an important determinant for the activities of both RAMT and RUMT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNA(UUU)(Lys) species
BIOCHEMISTRY, 39(44), 13390–13395.
MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Anticodon / chemistry; Binding Sites; Humans; Nucleic Acid Conformation; Protein Binding; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Lys / chemistry; Ribosomal Proteins / chemistry; Structure-Activity Relationship; Thermodynamics; Uridine / analogs & derivatives; Uridine / chemistry
TL;DR:
The data suggest that tRNA(Lys)(UUU) species require anticodon domain modifications in the loop to impart an ordered structure to the anticodon for ribosomal binding to AAA and require a combination of modified nucleosides to bind AAG.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Role of modified nucleosides of yeast tRNA(Phe) in ribosomal binding
CELL BIOCHEMISTRY AND BIOPHYSICS, 33(3), 241–252.
author keywords: tRNA(Phe); anticodon; ASL; nucleoside modification; ribosome
MeSH headings : Nucleosides / genetics; Nucleosides / metabolism; RNA, Fungal / genetics; RNA, Fungal / metabolism; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Ribosomes / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism
TL;DR:
Effective ribosome binding of tRNAPhe is a combination of anticodon stem stability and the correct architecture and dynamics of the anticodon loop, and 2′O-methylation of guanosine at wobble position 34 (Gm34) is identified as being responsible for the characteristically enhanced chemical reactivity of C1400 in Escherichia coli 16S rRNA upon ribosomal footprinting of yeast t RNAPhe.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Synthesis and properties of uniquely modified oligoribonucleotides: Yeast tRNA(Phe) fragments with 6-methyluridine and 5,6-dimethyluridine at site-specific positions
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 19(3), 515–531.
MeSH headings : Anticodon; Magnetic Resonance Spectroscopy; Methylation; Molecular Conformation; Oligoribonucleotides / chemical synthesis; Oligoribonucleotides / chemistry; Organophosphorus Compounds / chemistry; RNA, Transfer, Phe / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Uridine / analogs & derivatives; Uridine / chemistry; Yeasts / chemistry
TL;DR:
Stability when the modified uridine is in a loop is sequence context dependent, and can not, at this time, be predicted from the location in the loop, but decrease in RNA duplex stability is predictable.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
A distinctive RNA fold: The solution structure of an analogue of the yeast tRNA(Phe) T psi C domain
BIOCHEMISTRY, 38(27), 8647–8656.
MeSH headings : Anticodon / chemistry; Base Sequence; Crystallography, X-Ray; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular / methods; Nucleic Acid Conformation; Pseudouridine / chemistry; RNA, Fungal / chemistry; RNA, Transfer, Phe / chemistry; Saccharomyces cerevisiae / chemistry; Solutions; Uridine / analogs & derivatives; Uridine / chemistry
TL;DR:
It is believed that the structure determined may represent an intermediate in the folding pathway during the maturation of tRNA, which has a considerable resemblance to the analogous domain in the crystal structure of the full-length yeast tRNAPhe.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Experimental models of protein-RNA interaction: Isolation and analyses of tRNA(Phe) and U1 snRNA-binding peptides from bacteriophage display libraries
JOURNAL OF PROTEIN CHEMISTRY, 18(4), 425–435.
author keywords: phage peptide display library; peptide-RNA binding; tRNA; U1 snRNA
MeSH headings : Amino Acid Sequence; Anticodon; Bacteriophages; Base Sequence; Biotinylation; Circular Dichroism; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Library; Peptides / chemistry; Peptides / metabolism; RNA, Small Nuclear / chemistry; RNA, Small Nuclear / metabolism; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / metabolism; Spectrometry, Fluorescence
TL;DR:
These methodologies demonstrate the feasibility of rapidly identifying, isolating, and initiating the analyses of small peptides that bind to RNAs in an effort to define better the chemistry, structure, and function of protein–RNA complexes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Folding of pyrimidine-enriched RNA fragments from the vicinity of the internal ribosomal entry site of Hepatitis A virus
NUCLEIC ACIDS RESEARCH, 27(2), 665–673.
MeSH headings : Base Pairing; Base Sequence; Circular Dichroism; Hepatovirus / genetics; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Potentiometry; Protein Biosynthesis; Pyrimidine Nucleotides / chemistry; RNA, Viral / chemistry; Ribosomes / metabolism
TL;DR:
A series of possible models in which chain folding draws the strand termini closer together, possibly serving to pull the attached WC hairpin domains together and providing a functional advantage by nucleating reversible formation of a more viable RNA substrate are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Orientation of the tRNA anticodon in the ribosomal P-site: Quantitative footprinting with U-33-modified, anticodon stem and loop domains
RNA, 5(9), 1191–1199.
author keywords: anticodon stem/loops; modified nucleosides; quantitative footprinting; ribosome
MeSH headings : Aldehydes / pharmacology; Anticodon / genetics; Antiviral Agents / pharmacology; Base Sequence; Butanones; Dose-Response Relationship, Drug; Genetic Techniques; Kinetics; Molecular Sequence Data; Mutagens / pharmacology; RNA, Fungal / genetics; RNA, Fungal / metabolism; RNA, Ribosomal, 16S / metabolism; RNA, Transfer / genetics; RNA, Transfer / metabolism; RNA, Transfer, Phe / metabolism; Ribosomes / genetics; Ribosomes / metabolism; Sulfuric Acid Esters / pharmacology; Temperature
TL;DR:
Two residues, G926 and G1338, were afforded significantly greater protection by both yeast tRNA(Phe) and the ASL-U33 than other residues, such as A532, A794, C795, and A1339, which are important to efficient P-site binding of tRNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Single atom modification (O -> S) of tRNA confers ribosome binding
RNA, 5(2), 188–194.
author keywords: 2-thiouridine; anticodon conformation; anticodon stem loop analogs; nucleoside modifications; ribosome; translation; tRNA(LyS)
MeSH headings : Aldehydes / metabolism; Anticodon / genetics; Butanones; Escherichia coli / metabolism; Humans; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Nucleic Acid Denaturation / genetics; Nucleic Acid Hybridization / genetics; RNA, Fungal / genetics; RNA, Transfer, Lys / chemistry; RNA, Transfer, Lys / genetics; Ribosomes / metabolism; Spectrum Analysis; Temperature; Thiouridine / analogs & derivatives; Thiouridine / metabolism
TL;DR:
It is concluded that s2U34 in tRNALysSUU and in other s2 U34-containing tRNAs is critical for generating an anticodon conformation that leads to effective codon interaction in all organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Structural and functional roles of the N1-and N3-protons of Psi at tRNA's position 39
NUCLEIC ACIDS RESEARCH, 27(17), 3543–3549.
MeSH headings : Anticodon / chemistry; Genes, Fungal / genetics; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Protons; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Phe / chemistry; Ribosomes / chemistry; Structure-Activity Relationship; Temperature; Thermodynamics; Uridine / chemistry; Yeasts / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
The uridine in "U-turn": Contributions to tRNA-ribosomal binding
RNA, 5(4), 503–511.
author keywords: anticodon conformation; anticodon stem loop analogs; ASL; nucleoside modifications; ribosome; translation; tRNA(Phe) U-turn
MeSH headings : Anticodon / chemistry; Anticodon / genetics; Humans; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Nucleic Acid Denaturation; RNA, Fungal / chemistry; RNA, Fungal / genetics; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / metabolism; Ribosomes / genetics; Ribosomes / metabolism; Temperature; Uridine / chemistry; Uridine / genetics
TL;DR:
The results demonstrate that proton donations by the N3-H and 2'OH groups of U33 are not absolutely required for ribosomal binding, and suggest that the overall uridine conformation, including a dynamic (C3'-endo > C2'-endo) sugar pucker, anti-conformation, and ability of uracil to stack between C32 and A35-phosphate, are the contributing factors to a functional U-turn.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Thermodynamic contribution of nucleoside modifications to yeast tRNA(Phe) anticodon stem loop analogs
Acta Biochimica Polonica, 46(1), 163–172.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Modified RNAs as potential drug targets
Acta Biochimica Polonica, 45(1), 13–18.
Source: NC State University Libraries
Added: August 6, 2018
1997 conference paper
Ribosomal binding of modified tRNA anticodons related to thermal stability
Symposium on RNA Biology II. RNA: Tool and Target (1997: North Carolina Biotechnology Center) Research Triangle Park, North Carolina, USA, October 17-19, 1997 (Nucleic acids symposium series; no. 36), 36, 58–60. Oxford: Oxford University Press.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Unconventional structure of tRNA(Lys)SUU anticodon explains tRNA's role in bacterial and mammalian ribosomal frameshifting and primer selection by HIV-1
RNA, 3(4), 420–428.
Source: NC State University Libraries
Added: August 6, 2018
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