Works (209)

Updated: April 22nd, 2024 04:47

2024 journal article

A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 752.

By: A. Pasqui*, V. Cicaloni*, L. Tinti*, A. Guiotto n, C. Tinti*, A. Mori*, M. Bruttini*, J. Hayek* ...

author keywords: Rett syndrome; MECP2 mutations; Precision medicine; Proteomics; Oxidative stress
TL;DR: By employing a multidisciplinary approach encompassing proteomics and bioinformatics analyses, as well as molecular biology assays, the study uncovered phenotypic responses linked to specific MECP2 gene mutations, contributing to a better understanding of the complexity of RTT molecular pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2024 article

Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study

Ferrara, F., Yan, Xi, Pecorelli, A., Guiotto, A., Colella, S., Pasqui, A., … Valacchi, G. (2024, April 8). JOURNAL OF COSMETIC DERMATOLOGY, Vol. 4.

By: F. Ferrara*, . Yan*, A. Pecorelli*, A. Guiotto*, S. Colella*, A. Pasqui*, J. Ivarrson*, S. Lynch* ...

author keywords: 4HNE; inflammasome; inflammation; pollution; skin barrier
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024

2024 review

Cutaneous Redox Senescence

[Review of ]. BIOMEDICINES, 12(2).

By: M. Sarandy n, R. Goncalves* & G. Valacchi n

author keywords: cutaneous senescence; reactive oxygen species; inflammation; biochemistry; molecular signaling
TL;DR: An updated and more comprehensive approach to investigating skin senescence should include further assays of ox-inflammatory molecular pathways that can consolidate the understanding of cutaneous redox senescence. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 18, 2024

2024 journal article

Ethosomes for Curcumin and Piperine Cutaneous Delivery to Prevent Environmental-Stressor-Induced Skin Damage

ANTIOXIDANTS, 13(1).

By: F. Ferrara*, A. Bondi*, W. Pula*, C. Contado*, A. Baldisserotto*, S. Manfredini*, P. Boldrini*, M. Sguizzato* ...

author keywords: ethosomes (ETs); curcumin (CUR); piperin (PIP); skin; environmental stress
TL;DR: The results highlighted that ETs can promote the skin permeation of curcumin, suggesting their possible application for the prevention of skin damage due to exogenous stressors. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2024 journal article

Nutlin-3 Loaded Ethosomes and Transethosomes to Prevent UV-Associated Skin Damage

LIFE-BASEL, 14(1).

By: E. Esposito*, F. Ferrara*, M. Drechsler*, O. Bortolini*, D. Ragno*, S. Toldo*, A. Bondi*, A. Pecorelli* ...

author keywords: nutlin-3; ethosomes; transethosomes; skin damage; UV radiations
TL;DR: Ex vivo data suggest a better efficacy of transethosomes to promote nutlin-3 delivery within the skin, with respect to ethosomes, as well as in ex vivo skin explants exposed to UV radiations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2024 journal article

Signature of paraoxonases in the altered redox homeostasis in Alzheimer's disease

CHEMICO-BIOLOGICAL INTERACTIONS, 388.

author keywords: Paraoxonase 1; Paraoxonase 2; 4-Hydroxynonenal; Oxidative stress
TL;DR: The altered oxidative stress homeostasis in the 3xTg-AD female mice may be related to an early reduction in activity and expression of PONs enzymes most likely via a reduced brain arylesterases activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2024 journal article

Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multi pollutant exposure

EXPERIMENTAL DERMATOLOGY, 33(1).

By: F. Ferrara*, A. Pecorelli*, E. Pambianchi*, S. White*, H. Choudhary*, A. Casoni*, G. Valacchi*

author keywords: 4HNE; COX2; inflammation; pollution; skin barrier
TL;DR: This study is among the first to investigate the combined effects of three of the most harmful outdoor stressors on human skin and confirms that daily topical of an antioxidant application may prevent pollution-induced skin damage. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 29, 2024

2023 journal article

Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins

FRONTIERS IN NUTRITION, 10.

By: D. Nieman*, J. Woo*, C. Sakaguchi*, A. Omar*, Y. Tang*, K. Davis*, A. Pecorelli n, G. Valacchi n, Q. Zhang*

author keywords: astaxanthin; exercise; proteomics; oxylipins; inflammation; cytokines
TL;DR: It is supported that 4-week astaxanthin versus placebo supplementation did not counter exercise-induced increases in plasma cytokines and oxylipins but was linked to normalization of post-exercise plasma levels of numerous immune-related proteins including immunoglobulins within 24 h. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 17, 2023

2023 journal article

Bilosomes and Biloparticles for the Delivery of Lipophilic Drugs: A Preliminary Study

ANTIOXIDANTS, 12(12).

author keywords: bile acids; nanovesicles; nanoparticles; SLN; NLC; drug solubility; nanotechnology; poorly water-soluble drugs; immunofluorescence; inflammasome
TL;DR: Immunofluorescence experiments indicated that ursodeoxycholic acid bilosomes containing budesonide are effective in reducing the inflammatory response induced by glucose oxidase stimuli and counteract ox-inflammatory damage within intestinal cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 review

Blueberry Supplementation and Skin Health

[Review of ]. ANTIOXIDANTS, 12(6).

By: J. Ivarsson n, A. Pecorelli*, M. Lila n & G. Valacchi n

author keywords: blueberries; skin; inflammation; polyphenol; antioxidant
TL;DR: The argument for blueberries to possibly be an effective agent for skin health is built and the need for further research to elucidate the mechanisms behind the use of both topical application and dietary supplementation with blueberry to bolster cutaneous systems and defensive mechanisms is highlighted. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 14, 2023

2023 review

Bone Fracture in Rett Syndrome: Mechanisms and Prevention Strategies

[Review of ]. CHILDREN-BASEL, 10(12).

By: C. Caffarelli*, A. Al Refaie*, C. Mondillo*, M. De Vita*, L. Baldassini*, G. Valacchi n, S. Gonnelli*

author keywords: Rett syndrome; fractures; osteoporosis; calcium; vitamin D; bisphosphonates
TL;DR: The knowledge on risk factors for fragility fracture in patients with Rett syndrome is summarized and a possible diagnostic and therapeutic care pathway for improving low bone mineral density and reducing the risk of fragility fractures is suggested. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 8, 2024

2023 article

CADMIUM EXPOSURE AFFECTS THE PROGRESSION OF HUMAN METASTATIC MELANOMA BY INDUCING A DEREGULATION OF ANTIOXIDANT CELL RESPONSE

Casoni, A., Benedusi, M., Cervellati, F., Pecorelli, A., Ferrara, F., Vallese, A., & Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 42–43.

By: A. Casoni*, M. Benedusi*, F. Cervellati*, A. Pecorelli*, F. Ferrara*, A. Vallese*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

CONSTITUTIVE ACTIVATION OF NLRP3 INFLAMMASOME MACHINERY IN EX-VIVO MODELS OF RETT SYNDROME: FROM PATHOGENETIC ROLE TO NEW POTENTIAL THERAPEUTIC TARGET

Cordone, V., Pecorelli, A., Ferrara, F., Guiotto, A., Hayek, J., Cervellati, C., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 12–12.

By: V. Cordone*, A. Pecorelli*, F. Ferrara*, A. Guiotto*, J. Hayek*, C. Cervellati*, F. Amicarelli*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

Caffeic acid-loaded lipid nanoparticles as a tool to protect skin against oxidative stress: formulation and evaluation on human skin explants

Sguizzato, M., Ferrara, F., Valacchi, G., Cortesi, R., & Esposito, E. (2023, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 198, pp. S19–S19.

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 journal article

Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(23).

author keywords: oxinflammation; inflammasome; pollutants; skin
TL;DR: Among all environmental pollutants, O3, MP, and UV represented the main pollutants affecting cutaneous redox homeostasis; of note, the NLRP1 and NLRP6 inflammasomes were the main ones modulated by these outdoor stressors, suggesting their role as possible molecular targets in preventing skin disorders and the inflammaging events associated with environmental pollutants exposure. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 24, 2023

2023 article

Deregulated NLRP3 inflammasome response due to a constitutive activation of NF-kappa B p65 pro-inflammatory pathway in lymphomonocytes of Rett syndrome patients

Cordone, V., Vallese, A., Pecorelli, A., Guiotto, A., Ferrara, F., Benedusi, M., … Valacchi, G. (2023, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 198, pp. S21–S22.

By: V. Cordone*, A. Vallese*, A. Pecorelli n, A. Guiotto*, F. Ferrara*, M. Benedusi*, F. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 journal article

Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach

ANTIOXIDANTS, 12(7).

By: R. Hoskin n, M. Grace n, A. Guiotto n, A. Pecorelli n, G. Valacchi n & M. Lila n

author keywords: sustainability; value-added; repurposing; skin health; cosmeceuticals
TL;DR: It is demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 17, 2023

2023 article

Editorial: Cell cycle control as a new therapeutic approach for SARS-CoV-2 infection

Rizzo, R., Caccuri, F., Valacchi, G., & Zauli, G. (2023, February 1). FRONTIERS IN PHARMACOLOGY, Vol. 14.

By: R. Rizzo*, F. Caccuri*, G. Valacchi n & G. Zauli*

author keywords: cell cycle; SARS-CoV-2; p53; cytokine storm; idasanutlin
TL;DR: The authors propose using EVs to transport small-molecule MDM2 inhibitors like Nutlin-3 and idasanutlin by enhancing p53 survival and may help modify the IFN signaling pathway and lessen the overall pro-inflammatory burden during COVID-19. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023

2023 journal article

Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii)

NUTRIENTS, 15(4).

author keywords: non-mulberry silkworm pupae; angiotensin converting enzyme-inhibitory peptides; antioxidative peptides; ultrafiltration; anti-inflammatory peptides
MeSH headings : Animals; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Antioxidants / pharmacology; Protein Hydrolysates / pharmacology; Bombyx; Pupa; Endothelial Cells; Lipopolysaccharides; Peptides / pharmacology; Hypertension; Hydrolysis
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 20, 2023

2023 article

INFLAMMASOMES REGULATION BY ENVIRONMENTAL POLLUTANTS IN HUMAN SKIN

Ferrara, F., Pecorelli, A., Guiotto, A., Vallese, A., Cordone, V., Benedusi, M., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 38–39.

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 journal article

Identification of bromelain subfamily proteases encoded in the pineapple genome

SCIENTIFIC REPORTS, 13(1).

By: A. Yow n, H. Bostan n, R. Young*, G. Valacchi n, N. Gillitt, P. Perkins-Veazie n, Q. Xiang n, M. Iorizzo n

Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 journal article

Lipid-Based Nanosystems for the Topical Application of Ferulic Acid: A Comparative Study

PHARMACEUTICS, 15(7).

author keywords: ferulic acid; antioxidant molecules; transferosomes; vesicles; monoolein aqueous dispersions; topical application; cryo-TEM
TL;DR: Results indicate that the LBNs produced with poloxamer 188 in their composition create a multilamellar system that effectively controls the release of the drug, and it is found that the type of non-ionic surfactant can impact the drug release rate. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 10, 2023

2023 article

MITOCHONDRIAL DYSFUNCTION AND NLRP3 INFLAMMASOME ACTIVATION IN AUTISM SPECTRUM DISORDER

Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 20–20.

By: A. Vallese n, A. Pecorelli*, V. Cordone*, F. Ferrara*, M. Benedusi*, F. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 review

Moderate red wine intake and cardiovascular health protection: a literature review

[Review of ]. FOOD & FUNCTION, 14(14), 6346–6362.

MeSH headings : Male; Humans; Female; Wine / analysis; Cardiovascular Diseases / prevention & control; Alcoholic Beverages; Cardiovascular System; Antioxidants; Ethanol; Alcohol Drinking
TL;DR: Red wine contains both alcoholic and non-alcoholic ingredients; however, it is yet unclear which is to blame for these effects, so new studies should focus more on the characterization of the individual components of wine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2023 journal article

Modulation of Cutaneous Carotenoid Content via Ozone Exposure

COSMETICS, 10(4).

By: F. Cervellati*, M. Benedusi*, A. Mastaloudis, V. Nagliati* & G. Valacchi n

author keywords: skin barrier; carotenoids; ozone exposure; Raman spectroscopy; statistics
TL;DR: Evaluating the variations in carotenoid content present in human skin prior to and after O3 exposure in 141 human subjects confirmed their importance in the maintenance of cutaneous redox homeostasis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 11, 2023

2023 journal article

Ox-inflammasome involvement in neuroinflammation

FREE RADICAL BIOLOGY AND MEDICINE, 207, 161–177.

By: A. Vallese*, V. Cordone*, A. Pecorelli* & G. Valacchi n

TL;DR: The current knowledge on the involvement of inflammasome in the main neuropathologies is provided, emphasizing the importance to further clarify the role of oxidative stress in its activation including therole of mitochondria in inflammaome-induced neuroinflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 article

OxInflammation in Alzheimer's disease

Cervellati, C., Zuliani, G., & Valacchi, G. (2023, December). NEURAL REGENERATION RESEARCH, Vol. 18, pp. 2709–2710.

By: C. Cervellati, G. Zuliani & G. Valacchi*

TL;DR: Or pro-inflammatory cytokines, such as reactive microglia, dysfunctional mitochondria, amyloid-β aggregates, are involved in inflammation and cell reprograming. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023

2023 article

Protective role of Ibuprofen-Curcumin co-load nanomicelles against oxidative stress and inflammasome activation mediated by indoor pollution exposure in A549 cells

Garces, M., Pecorelli, A., Moretton, M., Magnani, N., Chiapetta, D., Alvarez, S., … Valacchi, G. (2023, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 208, pp. S151–S152.

By: M. Garces*, A. Pecorelli*, M. Moretton*, N. Magnani*, D. Chiapetta, S. Alvarez*, P. Evelson*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024

2023 article

ROLE OF COENZYME Q10 IN MITOCHONDRIAL DYSFUNCTION AND OXIDATIVE DAMAGE IN RETT SYNDROME

Silvestri, S., Marcheggiani, F., Orlando, P., Cirilli, I., Mengarelli, F., Vallese, A., … Tiano, L. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 16–16.

By: S. Silvestri*, F. Marcheggiani*, P. Orlando*, I. Cirilli*, F. Mengarelli*, A. Vallese*, A. Pecorelli*, G. Valacchi*, L. Tiano*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

THE POSSIBLE MODULATION OF NRF2 AND NF-KB CROSSTALK BY SULFORAPHANE IN THE PROGRESSION OF HUMAN MELANOMA

Benedusi, M., Canella, R., Vallese, A., Casoni, A., Guerra, M., Rispoli, G., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 57–57.

By: M. Benedusi*, R. Canella*, A. Vallese*, A. Casoni*, M. Guerra*, G. Rispoli*, F. Ferrara*, F. Cervellati*, G. Valacchi n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

THE PROTECTIVE ROLE OF ENDOTHELIAL alpha 1AMPK IN AIRCRAFT NOISE-INDUCED VASCULAR DYSFUNCTION AND OXIDATIVE STRESS IS MEDIATED BY FASTING, EXERCISE AND PHARMACOLOGICAL TREATMENT

Cordone, V., Pecorelli, A., Ferrara, F., Guiotto, A., Hayek, J., Cervellati, C., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 11–12.

By: V. Cordone, A. Pecorelli, F. Ferrara, A. Guiotto, J. Hayek, C. Cervellati, F. Amicarelli, G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 journal article

Tension as a key factor in skin responses to pollution

SCIENTIFIC REPORTS, 13(1).

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n, A. Pasqui*, J. Therrien n & G. Valacchi n

TL;DR: The present work demonstrates that cutaneous exposure to ozone induces AMPs gene and protein levels and that the presence of tension can further modulate their expression, confirming the ability of pollution to induce the cutaneous expression of AMPs via redox signaling and corroborates the principle that skin explants are a good and reliable model to study skin responses. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 22, 2024

2023 article

The pathogenic axis between mitochondrial dysfunction and NLRP3 inflammasome activation in Autism Spectrum Disorder

Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 208, pp. S49–S49.

By: A. Vallese*, A. Pecorelli*, V. Cordone*, F. Ferrara*, M. Benedusi*, F. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 24, 2023

2022 article

Aberrant Mitochondrial Bioenergetics Fuels Inflammasome Machinery in Autism Spectrum Disorder

Pecorelli, A., Francesca, F., Cordone, V., Guiotto, A., Cervellati, C., Hayek, J., & Valacchi, G. (2022, February 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 180, pp. 97–98.

By: A. Pecorelli n, F. Francesca n, V. Cordone*, A. Guiotto*, C. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022

2022 journal article

Biological activity of new bioactive steroids deriving from biotransformation of cortisone

MICROBIAL CELL FACTORIES, 21(1).

author keywords: Biotransformations; Cortisone; Steroids; Neuroprotective; Anti-inflammatory; Antioxidant
MeSH headings : Cortisone; Antioxidants / pharmacology; Biotransformation; Steroids; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use
TL;DR: A preliminary in vitro study aimed at evaluating the mutagenic, anti-inflammatory, antioxidant and neuroprotective activity of SCA and SCB molecules obtained from the biotransformation of cortisone using Rh. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 5, 2022

2022 journal article

Chemoresistive Sensors for Cellular Type Discrimination Based on Their Exhalations

NANOMATERIALS, 12(7).

author keywords: chemoresistivity; nanostructures; sensors; cells; tumor; VOCs
TL;DR: The encouraging results presented here, although preliminary, foresee the development of sensor arrays capable of identifying tumor presence and its type. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022

2022 journal article

Dimethyl Fumarate-Loaded Transethosomes: A Formulative Study and Preliminary Ex Vivo and In Vivo Evaluation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(15).

By: F. Ferrara, M. Benedusi, F. Cervellati, M. Sguizzato, L. Montesi, A. Bondi, M. Drechsler, W. Pula, G. Valacchi*, E. Esposito

author keywords: dimethyl fumarate; cryogenic transmission electron microscopy; wound healing; transethosomes; transdermal delivery
MeSH headings : Administration, Cutaneous; Dimethyl Fumarate / pharmacology; Drug Delivery Systems / methods; Humans; Liposomes / chemistry; Phosphatidylcholines / metabolism; Skin / metabolism; Skin Absorption
TL;DR: The selected transethosome gel, loading 25 mg/mL dimethyl fumarate, was not irritant after cutaneous application under occlusion, suggesting its possible suitability in the treatment of wounds caused by diabetes mellitus or peripheral vascular diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 29, 2022

2022 article

Editorial: Angiogenesis and Nutraceuticals

Trabalzini, L., Tundis, R., Valacchi, G., Evelson, P. A., & Finetti, F. (2022, May 30). FRONTIERS IN PHARMACOLOGY, Vol. 13.

By: L. Trabalzini*, R. Tundis*, G. Valacchi n, P. Evelson* & F. Finetti*

author keywords: angiogenesis; nutraceuticals; endothelial cells; foods; food-derived products
TL;DR: Identification of natural food components for preventing or ameliorating angiogenesis-associated complications would be of a greater advantage because of their low toxicity or limited side effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2022 journal article

Ethosomes and Transethosomes as Cutaneous Delivery Systems for Quercetin: A Preliminary Study on Melanoma Cells

PHARMACEUTICS, 14(5).

author keywords: quercetin; ethosome; transethosome; in vitro release test; in vitro permeation test; Franz cell; wound healing; migration assay
TL;DR: To overcome quercetin low bioavailability, scarce solubility and poor permeability that hamper its pharmaceutical use, the drug was loaded in ethosomes and transethosomes based on different concentrations of phosphatidylcholine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2022 journal article

Extra Virgin Olive Oil Extracts of Indigenous Southern Tuscany Cultivar Act as Anti-Inflammatory and Vasorelaxant Nutraceuticals

ANTIOXIDANTS, 11(3).

By: L. Pozzetti*, F. Ferrara*, L. Marotta*, S. Gemma*, S. Butini*, M. Benedusi*, F. Fusi*, A. Ahmed* ...

author keywords: olive oil; traceability quality; food origin; luteolin; oleuropein; CaCo-2 cells; Nrf2; NF-kappa B
TL;DR: The nutraceutical properties of autochthonous Tuscany EVOO cv showed promising anti-inflammatory and vasorelaxant effects, both in the presence and absence of an intact endothelium. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022

2022 article

Inflammasome involvement in CS-induced damage in HaCaT keratinocytes

Prieux, R., Ferrara, F., Cervellati, F., Guiotto, A., Benedusi, M., & Valacchi, G. (2022, April 15). IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, Vol. 4.

By: R. Prieux*, F. Ferrara*, F. Cervellati*, A. Guiotto*, M. Benedusi* & G. Valacchi n

MeSH headings : Animals; Cytokines / metabolism; Inflammasomes / metabolism; Interleukin-1beta / metabolism; Keratinocytes / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Skin / metabolism
TL;DR: The importance of the inflammasome machinery in CS that more in general, in pollution, affects cutaneous tissues and the important cross-talk between different members of the NLRP inflammaome family is highlighted. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2022 article

Involvement Of Ferroptosis In Rett Syndrome

Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Cervellati, C., Hayek, J., … Pecorelli, A. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: A. Guiotto, V. Cordone, M. Benedusi, F. Cervellati, C. Cervellati, J. Hayek, G. Valacchi*, A. Pecorelli*

Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 article

Loss of Scavenger Receptor B1 (SR-B1) in Brain of a Rett Syndrome Mouse Model

Pecorelli, A., Ferrara, F., Guiotto, A., Vallese, A., Cordone, V., Belmonte, G., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: A. Pecorelli*, F. Ferrara*, A. Guiotto, A. Vallese*, V. Cordone, G. Belmonte, J. Hayek, C. Cervellati, G. Valacchi*

Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 6, 2023

2022 journal article

MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation

JOURNAL OF PERSONALIZED MEDICINE, 12(2).

author keywords: microRNAs; environmental risk factors; cutaneous tissues; ozone exposure
TL;DR: Investigation in human skin biopsies exposed to diesel fumes, ozone, and UV light for over 24 h of exposure found UV and ozone-induced microRNA alteration right after exposure, while the peak of their deregulations induced by diesel fumes was reached only at the end of the 24 h. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2022

2022 article

Mutations Specific Redox Regulation Pathway In Rett Syndrome By The Use Of Transcriptomics And Proteomics Approaches

Pasqui, A., Cicaloni, V., Tinti, L., Mori, A., Bruttini, M., Pecorelli, A., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: A. Pasqui*, V. Cicaloni, L. Tinti, A. Mori, M. Bruttini, A. Pecorelli*, C. Tinti, F. Dotta, S. Laura, G. Valacchi*

Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 review

Oxidative-Stress-Sensitive microRNAs in UV-Promoted Development of Melanoma

[Review of ]. CANCERS, 14(13).

By: A. Pecorelli n & G. Valacchi n

author keywords: skin cancer; sunlight; redox imbalance; miRNome; mutations; epigenome
TL;DR: Current evidence suggests a complex interaction between UV-promoted deregulation of redox-sensitive miRNAs and known signal-transduction pathways underlying malignant transformation of melanocytes to melanoma, which could have relevant implications for future therapeutic approaches aimed at counteracting UV-induced redox and miRNome imbalances. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022

2022 journal article

The constitutive activation of TLR4-IRAK1-NF kappa B axis is involved in the early NLRP3 inflammasome response in peripheral blood mononuclear cells of Rett syndrome patients

FREE RADICAL BIOLOGY AND MEDICINE, 181, 1–13.

By: V. Cordone*, F. Ferrara*, A. Pecorelli n, A. Guiotto*, A. Vitale*, F. Amicarelli*, C. Cervellati*, J. Hayek*, G. Valacchi n

author keywords: MeCP2; p65; Oxinflammation; Interleukin-18; Interleukin-1 beta
MeSH headings : Humans; Inflammasomes / genetics; Inflammasomes / metabolism; Interleukin-1 Receptor-Associated Kinases / genetics; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Leukocytes, Mononuclear / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Rett Syndrome / genetics; Rett Syndrome / metabolism; Toll-Like Receptor 4 / genetics
TL;DR: The deregulation of inflammasome components was even found in THP-1 cells silenced for MECP2 and importantly, in plasma compartment of RTT subjects, from the earliest stages of the pathology or in correlation with the severity of MeCP2 mutations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 14, 2022

2022 journal article

Ubiquitination as a key regulatory mechanism for O-3-induced cutaneous redox inflammasome activation

REDOX BIOLOGY, 56.

Contributors: F. Ferrara*, V. Cordone*, A. Pecorelli*, M. Benedusi*, E. Pambianchi*, A. Guiotto*, A. Vallese*, F. Cervellati*, G. Valacchi*

author keywords: Inflammasomes; OxInflammation; Proteasome; UBR2; N-end rule pathway
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Air Pollutants; Apoptosis Regulatory Proteins / genetics; Catalase / metabolism; Cytokines / metabolism; Environmental Pollutants; Humans; Hydrogen Peroxide / metabolism; Inflammasomes / metabolism; NLR Proteins / metabolism; Oxidation-Reduction; Ozone / metabolism; Particulate Matter; Reactive Oxygen Species / metabolism; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
TL;DR: It is reported for the first time that O3, one of the most toxic pollutants, activates the NLRP1 inflammasome in human keratinocytes via oxidative stress mediators as hydrogen peroxide (H2O2) and 4-hydroxy-nonenal (4HNE). (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 12, 2022

2022 article

Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox Inflammasome activation

Ferrara, F., Cordone, V., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: F. Ferrara*, V. Cordone*, A. Pecorelli n, M. Benedusi*, E. Pambianchi n, A. Guiotto*, A. Vallese*, F. Cervellati*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 6, 2023

2022 review

Ultraviolet Light Protection: Is It Really Enough?

[Review of ]. ANTIOXIDANTS, 11(8).

By: P. Farris* & G. Valacchi*

author keywords: skin aging; ultraviolet light; solar radiation; pollution; reactive oxygen species; oxidative stress; antioxidants; chelators
TL;DR: An updated, more comprehensive approach to environmental or atmospheric aging protection should include sun protective measures, broad spectrum sunscreens, antioxidants, chelating agents, and DNA repair enzymes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 6, 2022

2021 journal article

"Plurethosome" as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation

PHARMACEUTICS, 13(8).

By: M. Sguizzato*, F. Ferrara*, P. Mariani*, A. Pepe*, R. Cortesi*, N. Huang*, F. Simeliere*, P. Boldrini* ...

author keywords: phosphatidylcholine; poloxamer; mangiferin; in vitro diffusion; antioxidant
TL;DR: The antioxidant and anti-inflammatory potential effect of mangiferin against pollutants was evaluated on 3D human skin models exposed to O3 and the protective effect exerted by plurethosomes and transethosomes suggests their possible application to enhance the cutaneous antioxidant defense status. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2021 journal article

Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage

COSMETICS, 8(4).

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n, M. Grace n, J. Therrien n, M. Lila n, G. Valacchi n

author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
TL;DR: It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 2, 2021

2021 article

Alteration of cellular defensive response and a possible involvement of ferroptosis cell death in Rett syndrome disorder

Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Hayek, J., Cervellati, C., … Pecorelli, A. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.

By: A. Guiotto*, V. Cordone*, M. Benedusi*, F. Cervellati*, J. Hayek*, C. Cervellati*, G. Valacchi*, A. Pecorelli*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure

FREE RADICAL BIOLOGY AND MEDICINE, 166, 324–336.

By: M. Garces*, N. Magnani*, A. Pecorelli*, V. Calabro*, T. Marchini*, L. Caceres*, E. Pambianchi*, J. Galdoporpora* ...

author keywords: Nanoparticles; Lung epithelium; Nanotoxicology; Oxidative metabolism; NADPH oxidase; Mitochondria
MeSH headings : Animals; Hydrogen Peroxide; Lung; Metal Nanoparticles / toxicity; Mice; Oxygen; Silver
TL;DR: Results show that AgNP exposure alters O2 metabolism leading to a redox imbalance, which may be responsible for the impaired lung function observed due to alveolar epithelial injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 19, 2021

2021 review

Altered Bone Status in Rett Syndrome

[Review of ]. LIFE-BASEL, 11(6).

By: A. Pecorelli n, V. Cordone*, M. Schiavone n, C. Caffarelli*, C. Cervellati*, G. Cerbone*, S. Gonnelli*, J. Hayek*, G. Valacchi n

author keywords: MeCP2; bone mineral density; bone metabolism; osteoblast; WNT pathway
TL;DR: Evidence from human and animal studies supports the idea that MECP2 mutation could be associated with altered epigenetic regulation of bone-related factors and signaling pathways, including SFRP4/WNT/β-catenin axis and RANKL/RANK/OPG system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 12, 2021

2021 article

BACE1 role in Alzheimer's disease and other dementias: from the theory to the practice

Cervellati, C., Valacchi, G., & Zuliani, G. (2021, December). NEURAL REGENERATION RESEARCH, Vol. 16, pp. 2407–2408.

By: C. Cervellati*, G. Valacchi* & G. Zuliani

TL;DR: Alzheimer's disease is a multifactorial and multifaceted disease, with a complex and still not completely understood pathogenesis, and it is now amply recognized that a combination of multiple biochemical, immune system and vascular abnormalities must also occur to define the direction of disease trajectory. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 review

Bench approaches to study the detrimental cutaneous impact of tropospheric ozone

[Review of ]. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 31(1), 137–148.

By: B. Petracca, B. Rothen-Rutishauser*, G. Valacchi* & M. Eeman

author keywords: Environmental pollution; Skin; 3D skin tissue model; Oxidative stress; Skin protection
MeSH headings : Air Pollutants / adverse effects; Air Pollutants / analysis; Cities; Humans; Lipid Peroxidation; Oxidative Stress; Ozone / adverse effects; Ozone / analysis; Skin / metabolism
TL;DR: Having a better understanding of O 3 effects on skin barrier properties and stress responses could help the whole dermato-cosmetic industry to design innovative protective solutions and develop specific cosmetic regime to protect the skin of every citizen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

2021 journal article

Circadian Deregulation as Possible New Player in Pollution-Induced Tissue Damage

ATMOSPHERE, 12(1).

By: M. Benedusi*, E. Frigato*, C. Bertolucci* & G. Valacchi n

author keywords: circadian clock; pollution; antioxidant system
TL;DR: It is hypothesized that chronodistruption can exacerbate cell vulnerability to exogenous damaging agents, and a possible common mechanism of action in deregulation of the homeostasis of the pulmonary, cardiovascular and cutaneous tissues and in its involvement in the development of pathological conditions is suggested. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 15, 2021

2021 review

Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer's Disease: A Narrative Review

[Review of ]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021.

MeSH headings : Alzheimer Disease / etiology; Alzheimer Disease / metabolism; Alzheimer Disease / pathology; Animals; Anti-Inflammatory Agents / metabolism; Antioxidants / metabolism; Humans; Inflammation / complications; Lipoproteins, HDL / metabolism; Oxidative Stress
TL;DR: This review summarized and critically analyzed the most significant findings linking HDL accessory proteins and AD and discusses the most convincing hypothesis explaining the mechanism by which an observed systemic occurrence may have repercussions in the brain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 22, 2021

2021 journal article

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 5(171).

By: I. Dijkhoff*, B. Petracca*, R. Prieux*, G. Valacchi n, B. Rothen-Rutishauser* & M. Eeman*

MeSH headings : Cell Differentiation; Cells, Cultured; Coculture Techniques; Epidermal Cells; Epidermis; Filaggrin Proteins; Humans; Keratinocytes; Skin
TL;DR: This protocol represents a straightforward and reproducible in vitro method to cultivate reconstructed human epidermis as a tool to assess environmental effects and a broad range of skin-related studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 21, 2021

2021 journal article

Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure

ANTIOXIDANTS, 10(12).

By: E. Pambianchi n, F. Ferrara*, A. Pecorelli n, M. Benedusi*, H. Choudhary*, J. Therrien*, G. Valacchi n

author keywords: cosmeceuticals; pollution; iron-chelator
TL;DR: It is suggested that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022

2021 article

Deregulated inflammasome response in Rett syndrome

Cordone, V., Pecorelli, A., Falone, S., Hayek, J., Amicarelli, F., & Valacchi, G. (2021, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 177.

By: V. Cordone*, A. Pecorelli*, S. Falone*, J. Hayek*, F. Amicarelli* & G. Valacchi*

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 journal article

Ethosomes and Transethosomes for Mangiferin Transdermal Delivery

ANTIOXIDANTS, 10(5).

author keywords: ethosomes; transethosomes; mangiferin; franz cell; antioxidants
TL;DR: The effectiveness of mangiferin loaded in nanosystems to protect cells from damage was demonstrated, evaluating, in vitro, the antioxidant and anti-inflammatory effect of ethosomes and transethosomes on human keratinocytes exposed to cigarette smoke as an oxidative and inflammatory challenger. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 journal article

Formulative Study and Intracellular Fate Evaluation of Ethosomes and Transethosomes for Vitamin D3 Delivery

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(10).

author keywords: cell culture; cholecalciferol; cryogenic transmission electron microscopy; in vitro test; light microscopy; lipid nanocarriers; transmission electron microscopy
MeSH headings : Cell Line; Chemistry, Pharmaceutical / methods; Cholecalciferol / administration & dosage; Cholecalciferol / metabolism; Cholecalciferol / pharmacology; Drug Carriers / chemistry; Drug Delivery Systems / methods; Fibroblasts / drug effects; Humans; Keratinocytes / drug effects; Lipids / chemistry; Liposomes / chemistry; Myoblasts / drug effects; Nanocapsules / chemistry; Pilot Projects; Skin / metabolism; Skin Absorption; Surface-Active Agents / metabolism
TL;DR: Both ethosomes and transethosomes proven to have physicochemical properties optimal for transdermal penetration and efficient vitamin D3 loading; moreover, nanocarriers were easily internalized by all cell types, although they followed distinct intracellular fates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 28, 2021

2021 journal article

Impaired mitochondrial quality control in Rett Syndrome

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 700.

By: I. Crivellari*, A. Pecorelli n, V. Cordone*, S. Marchi*, P. Pinton*, J. Hayek*, C. Cervellati*, G. Valacchi n

author keywords: RTT Syndrome; Oxidative stress; Mitochondrial quality control; Mitophagy; Apoptosis
MeSH headings : Adolescent; Adult; Apoptosis; Caspase 3 / genetics; Caspase 3 / metabolism; Caspase 7 / genetics; Caspase 7 / metabolism; Child; Dynamins / genetics; Dynamins / metabolism; Female; Fibroblasts / metabolism; Fibroblasts / pathology; GTP Phosphohydrolases / genetics; GTP Phosphohydrolases / metabolism; Humans; Membrane Proteins / genetics; Membrane Proteins / metabolism; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mitochondria / genetics; Mitochondria / metabolism; Mitochondria / pathology; Mitochondrial Membrane Transport Proteins / genetics; Mitochondrial Membrane Transport Proteins / metabolism; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Mitophagy; Oxidation-Reduction; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology
TL;DR: It is shown that RTT fibroblasts have networks of hyperfused mitochondria with morphological abnormalities and increased mitochondrial volume, shedding light on new aspects of mitochondrial dysfunction in RTT that are represented by defective mitochondrial QC pathways, providing new potential targets for a therapeutic intervention aimed at slowing down clinical course and manifestations in the affected patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 15, 2021

2021 article

Improper enzymatic defensive responses in Rett syndrome disorder

Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Hayek, J., Cervellati, C., … Pecorelli, A. (2021, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 177.

By: A. Guiotto*, V. Cordone*, M. Benedusi*, F. Cervellati*, J. Hayek*, C. Cervellati*, G. Valacchi n, A. Pecorelli n

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 journal article

Inflammasome Activation in Pollution-Induced Skin Conditions

PLASTIC AND RECONSTRUCTIVE SURGERY, 147(1S-2), 15S–24S.

By: F. Ferrara*, R. Prieux*, B. Woodby* & G. Valacchi*

MeSH headings : Air Pollutants / adverse effects; Air Pollution / adverse effects; Animals; Dermatitis / immunology; Dermatitis / pathology; Dermatitis / prevention & control; Disease Models, Animal; Environmental Exposure / adverse effects; Furans; Heterocyclic Compounds, 4 or More Rings / pharmacology; Heterocyclic Compounds, 4 or More Rings / therapeutic use; Humans; Indenes; Inflammasomes / antagonists & inhibitors; Inflammasomes / immunology; Inflammasomes / metabolism; Interleukin-18 / metabolism; Interleukin-1beta / metabolism; Mice; NLR Family, Pyrin Domain-Containing 3 Protein / antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Nitriles / pharmacology; Nitriles / therapeutic use; Skin / drug effects; Skin / immunology; Skin / pathology; Skin Aging / immunology; Sulfonamides; Sulfones / pharmacology; Sulfones / therapeutic use
TL;DR: The cutaneous inflammasome is proposed as a novel target of pollutant exposure and the eventual usage of inflamMASome inhibitor as new technologies to counteract pollution-induced skin damage. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2021 article

Mitochondrial dynamics and quality control pathways impairment in Rett Syndrome and Autism Spectrum Disorder

Pecorelli, A., Guiotto, A., Cordone, V., Cervellati, F., Benedusi, M., Cervellati, C., … Valacchi, G. (2021, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 177, pp. S17–S18.

By: A. Pecorelli n, A. Guiotto*, V. Cordone*, F. Cervellati*, M. Benedusi*, C. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: February 28, 2022

2021 article

Mitochondrial dysfunction fuels inflammasome machinery in Autism Spectrum Disorder

Pecorelli, A., Cordone, V., Guiotto, A., Cervellati, F., Benedusi, M., Cervellati, C., … Valacchi, G. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.

By: A. Pecorelli n, V. Cordone*, A. Guiotto*, F. Cervellati*, M. Benedusi*, C. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 article

NALP1 involvement in cigarette smoke induces cutaneous inflammation

Prieux, R., Benedusi, M., Ferrara, F., Guiotto, A., Cervellati, F., & Valacchi, G. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.

By: R. Prieux, M. Benedusi, F. Ferrara, A. Guiotto, F. Cervellati & G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

MOLECULES, 26(13).

By: R. Hoskin n, E. Pambianchi n, A. Pecorelli n, M. Grace n, J. Therrien*, G. Valacchi n, M. Lila n

author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
TL;DR: The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 23, 2021

2021 journal article

Oxidative metabolism in the cardiorespiratory system after an acute exposure to nickel-doped nanoparticles in mice

TOXICOLOGY, 464.

By: M. Garces*, T. Marchini*, L. Caceres*, V. Calabro*, A. Mebert*, M. Victoria Tuttolomondo*, T. Vico*, V. Vanasco* ...

author keywords: nanoparticles; nickel; reactive oxygen species; oxidative stress; NADPH oxidase
MeSH headings : Animals; Antioxidants / metabolism; Female; Lung / drug effects; Lung / metabolism; Male; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Mice; Mitochondria / drug effects; Nickel / chemistry; Oxidation-Reduction / drug effects; Oxidative Stress / drug effects; Oxygen Consumption / drug effects; Silicon Dioxide / chemistry
TL;DR: The results showed that the O2 metabolism analysis is a critical area of study following Ni-NP inhalation, and provides novel data linking the redox metabolisms alterations elicited by exposure to Ni (II) adsorbed to NP and cardiorespiratory toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 29, 2021

2021 article

Proteome composition and profiling of bioactive peptides of edible Antheraea assamensis pupae by sequential enzymatic digestion and kinetic modeling of in vitro gastrointestinal digestion

Sarkar, P., Valacchi, G., & Duary, R. K. (2021, October 28). EUROPEAN FOOD RESEARCH AND TECHNOLOGY, Vol. 10.

By: P. Sarkar*, G. Valacchi* & R. Duary*

author keywords: Insect hydrolysate; Papain; Thermolysin; Gastrointestinal digestion; Free amino acids; Enzyme kinetics
TL;DR: The indigenous Muga (Antheraea assamensis) pupae proteome is profile and the suitable parameters to procure ACE inhibitory, DPP-IV inhibitory and antioxidative peptide mix with suitable enzymatic interventions are evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021

2021 review

SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?

[Review of ]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1486(1), 15–38.

By: B. Woodby n, M. Arnold* & G. Valacchi n

author keywords: air pollution; coronavirus; particulate matter; ozone; nitrogen dioxide; viral infection
MeSH headings : Adaptive Immunity; Air Pollutants / adverse effects; Air Pollution / adverse effects; COVID-19 / etiology; COVID-19 / immunology; COVID-19 / virology; Host Microbial Interactions; Humans; Immunity, Innate; Models, Biological; Pandemics; Particulate Matter / adverse effects; Receptors, Virus / physiology; Respiratory System / physiopathology; SARS-CoV-2 / immunology; SARS-CoV-2 / pathogenicity; SARS-CoV-2 / physiology; Toll-Like Receptors / physiology; Virus Internalization; Virus Replication
TL;DR: Air pollution exposure may affect different stages of the viral life cycle, including inhibition of mucociliary clearance, alteration of viral receptors and proteases required for entry, changes to antiviral interferon production and viral replication, changes in viral assembly mediated by autophagy, prevention of uptake by macrophages, and promotion of viral spread by increasing epithelial permeability. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2020

2021 journal article

Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents

ACS CHEMICAL NEUROSCIENCE, 12(9), 1716–1736.

By: A. Grillo*, F. Fezza*, G. Chemi*, R. Colangeli*, S. Brogi*, D. Fazio*, S. Federico*, A. Papa* ...

author keywords: Endocannabinoid system; fatty acid amide hydrolase; enzyme inhibitors; selective inhibitors; epilepsy; temporal lobe epilepsy; seizures
MeSH headings : Amidohydrolases; Anticonvulsants / pharmacology; Endocannabinoids; Enzyme Inhibitors / pharmacology; Humans; Seizures
TL;DR: The discovery of selective anandamide catabolic enzyme fatty acid amide hydrolase (FAAH) inhibitors with promising antiepileptic efficacy are reported, starting from a further investigation of the authors' prototypical inhibitor 2a. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 article

The role of pulmonary ORCC and CLC-2 channels in the response to oxidative stress

Canella, R., Benedusi, M., Martini, M., Guiotto, A., Cervellati, F., & Valacchi, G. (2021, May 7). MOLECULAR & CELLULAR TOXICOLOGY, Vol. 5.

By: R. Canella*, M. Benedusi*, M. Martini*, A. Guiotto*, F. Cervellati* & G. Valacchi*

author keywords: Human lung epithelial cells; Chloride channels; Ozone; Oxidative stress; Patch clamp technique
TL;DR: It is suggested that O3 activates ORCC channels and slightly inhibited ClC-2 channels in the negative voltage range and opens the possibility of identifying the biomolecular changes induced by O3 allowing a possible pharmacological intervention towards chloride current due to oxidative stress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 article

Ubiquitination as a key regulatory mechanism for O-3-induced cutaneous redox inflammasome activation

Ferrara, F., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., Cervellati, F., & Valacchi, G. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.

By: F. Ferrara, A. Pecorelli, M. Benedusi, E. Pambianchi, A. Guiotto, F. Cervellati, G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2020 journal article

A proteomics approach to further highlight the altered inflammatory condition in Rett syndrome

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 696.

By: V. Cicaloni*, A. Pecorelli n, V. Cordone*, L. Tinti*, M. Rossi*, J. Hayek*, L. Salvini*, C. Tinti*, G. Valacchi n

author keywords: Rare disease; Rett syndrome; Inflammatory status; NLRP3 inflammasome; Mass spectrometry-based proteomics
MeSH headings : Adult; Female; Fibroblasts / chemistry; Humans; Inflammation / complications; Inflammation / metabolism; Protein Interaction Maps; Proteome / analysis; Proteome / metabolism; Proteomics; Rett Syndrome / complications; Rett Syndrome / metabolism; Young Adult
TL;DR: Results provide a detailed insight into the molecular pathways involved in RTT immune dysfunction that, causing tissue and organ damage, can increase the vulnerability of affected patients to unknown endogenous factors or infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021

2020 journal article

Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder

FASEB JOURNAL, 34(5), 6521–6538.

By: A. Pecorelli*, F. Ferrara*, N. Messano*, V. Cordone*, M. Schiavone*, F. Cervellati*, B. Woodby*, C. Cervellati*, J. Hayek*, G. Valacchi*

author keywords: 4-hydroxynonenal; fission; fusion; mitophagy; nuclear factor erythroid 2-related factor 2
MeSH headings : Adolescent; Adult; Autism Spectrum Disorder / metabolism; Autism Spectrum Disorder / pathology; Case-Control Studies; Child; Energy Metabolism; Female; Fibroblasts / metabolism; Fibroblasts / pathology; Humans; Male; Mitochondria / metabolism; Mitochondria / pathology; Mitochondrial Dynamics; Mitochondrial Proteins / metabolism; Oxidative Stress; Young Adult
TL;DR: It is suggested that many of the changes observed in mitochondria could represent compensatory mechanisms by which ASD cells try to adapt to altered energy demand, possibly resulting from a chronic oxinflammatory status. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2020 journal article

Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation

REDOX BIOLOGY, 28.

By: A. Pecorelli*, V. Cordone*, N. Messano*, C. Zhang*, S. Falone*, F. Amicarelli*, J. Hayek*, G. Valacchi*

author keywords: NLRP3; ASC; Inflammatory status; Cytokines; MeCP2
MeSH headings : Biomarkers; Cytokines / metabolism; Disease Susceptibility; Fibroblasts / metabolism; Fluorescent Antibody Technique; Humans; Inflammasomes / metabolism; Inflammation Mediators / metabolism; Interleukin-1beta / metabolism; NF-kappa B / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Protein Transport; Rett Syndrome / etiology; Rett Syndrome / metabolism
TL;DR: It is suggested that RTT patients exhibited a challenged inflammasome machinery at cellular and systemic level, which may contribute to the subclinical inflammatory state feedback observed in this pathology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019

2020 journal article

Circadian Clock and OxInflammation: Functional Crosstalk in Cutaneous Homeostasis

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020.

By: E. Frigato*, M. Benedusi*, A. Guiotto*, C. Bertolucci* & G. Valacchi*

MeSH headings : Cells, Cultured; Circadian Clocks / physiology; Homeostasis; Humans; Inflammation / metabolism; Inflammation / pathology; Keratinocytes / cytology; Keratinocytes / metabolism; Skin / metabolism; Skin / pathology
TL;DR: The results suggest that a synchronized circadian clock not only facilitates the protective role of NRF2 in terms of a faster and more efficient defensive response against environmental insults but also moderates the cellular damage resulting from a condition of chronic inflammation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2020 journal article

Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1866(7).

author keywords: Rett syndrome; Skin primary fibroblasts; Proteasome; alpha-Ring; PAC1; PAC2
MeSH headings : Codon, Nonsense / genetics; Dual Specificity Phosphatase 2 / genetics; Fibroblasts / metabolism; Gene Expression Regulation; Genetic Diseases, X-Linked / genetics; Genetic Diseases, X-Linked / pathology; Humans; Methyl-CpG-Binding Protein 2 / genetics; Neurodevelopmental Disorders / genetics; Neurodevelopmental Disorders / pathology; Primary Cell Culture; Proteasome Endopeptidase Complex / genetics; Proteolysis; Rett Syndrome / genetics; Rett Syndrome / pathology; Skin / metabolism; Skin / pathology; Ubiquitin / genetics
TL;DR: Molecular, transcription and proteomic analyses indicate that MeCP2 mutations down-regulate the expression of one proteasome subunit, α7, and of two chaperones, PAC1 and PAC2, which bind each other in the earliest step of proteAsome biogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 15, 2020

2020 journal article

Ethosomes for Coenzyme Q10 Cutaneous Administration: From Design to 3D Skin Tissue Evaluation

ANTIOXIDANTS, 9(6).

author keywords: ethosome; ubiquinone; H2O2; penetration enhancers; dermal administration; reconstituted human epidermis; small angle X-ray scattering
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020

2020 journal article

Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study

COLLOIDS AND SURFACES B-BIOINTERFACES, 185.

By: M. Sguizzato*, G. Valacchi*, A. Pecorelli*, P. Boldrini*, F. Simeliere*, N. Huang*, R. Cortesi*, E. Esposito*

author keywords: Biocompatible polymers; Polymer gels; In vitro diffusion; Polymer membranes; Gallic acid; Franz cell
MeSH headings : Adjuvants, Immunologic / pharmacology; Adjuvants, Immunologic / therapeutic use; Cell Line; Cell Movement / drug effects; Diffusion; Elasticity; Gallic Acid / pharmacology; Gallic Acid / therapeutic use; Gels / chemistry; Humans; Kinetics; Melanoma / drug therapy; Phase Transition; Poloxamer / chemistry; Rheology; Temperature; Viscosity; Wound Healing / drug effects
TL;DR: Scratch wound healing and migration assays conducted on human keratinocytes and melanoma cells demonstrated the ability of gallic acid loaded gel to inhibit cellular migration, suggesting its potential as adjuvant strategy for melanoma. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2020

2020 review

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

[Review of ]. PARTICLE AND FIBRE TOXICOLOGY, 17(1).

By: I. Dijkhoff*, B. Drasler*, B. Karakocak*, A. Petri-Fink*, G. Valacchi*, M. Eeman, B. Rothen-Rutishauser*

author keywords: Particulate matter; Air pollution; Urban pollution; Skin models; Skin; In vitro studies; In vivo studies; Oxidative stress; Inflammation; Barrier dysfunction
MeSH headings : Air Pollutants / toxicity; Air Pollution; Humans; Oxidative Stress; Particulate Matter / toxicity; Reactive Oxygen Species; Skin / drug effects
TL;DR: Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020

2020 journal article

Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease

SCIENTIFIC REPORTS, 10(1).

By: G. Zuliani*, A. Trentini*, V. Rosta*, R. Guerrini*, S. Pacifico*, S. Bonazzi*, A. Guiotto*, A. Passaro* ...

MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / blood; Alzheimer Disease / diagnosis; Amyloid Precursor Protein Secretases / blood; Aspartic Acid Endopeptidases / blood; Dementia, Vascular / blood; Dementia, Vascular / diagnosis; Female; Humans; Male
TL;DR: It is shown for the first time that the increase in peripheral BACE1 activity is a common feature of LOAD and VAD, thus underlying a further pathogenic link between these two forms of dementia. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2020 journal article

Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery

ANTIOXIDANTS & REDOX SIGNALING, 33(3), 191–210.

By: C. Cervellati*, A. Trentini*, A. Pecorelli* & G. Valacchi*

author keywords: Alzheimer's disease; inflammation; multiple sclerosis; vascular dementia
MeSH headings : Animals; Biomarkers; Blood-Brain Barrier / metabolism; Brain / metabolism; Brain / pathology; Disease Susceptibility; Dysbiosis; Humans; Inflammation / etiology; Inflammation / metabolism; Inflammation / pathology; Nervous System Diseases / etiology; Nervous System Diseases / metabolism; Nervous System Diseases / pathology; Oxidative Stress; Peripheral Nerves / metabolism; Peripheral Nerves / pathology
TL;DR: Reaching a definitive clinical/epidemiological appreciation of the etiopathogenic significance of the connection between peripheral and brain inflammation in neurologic disorders is pivotal since it could open novel therapeutic avenues for these diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2020 journal article

KRIT1 as a possible new player in melanoma aggressiveness

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 691.

By: J. Ercoli*, F. Finetti*, B. Woodby*, G. Belmonte*, C. Miracco*, G. Valacchi*, L. Trabalzini*

author keywords: KRIT1; Melanoma; Tumor suppressor; N-cadherin; Inflammation; beta-catenin
MeSH headings : Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Cell Movement / physiology; Cell Nucleus / metabolism; Cell Proliferation / genetics; Down-Regulation; Female; Gene Knockdown Techniques / methods; Humans; KRIT1 Protein / genetics; KRIT1 Protein / metabolism; Male; Melanocytes / metabolism; Melanoma / metabolism; Melanoma / pathology; Middle Aged; beta Catenin / metabolism
TL;DR: KRIT1 has been studied as a regulator of endothelial cell functions and represents a determinant in the pathogenesis of Cerebral Cavernous Malformation, a cerebrovascular disease characterized by the formation of clusters of abnormally dilated and leaky blood capillaries, which predispose to seizures, neurological deficits and intracerebral hemorrhage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 5, 2020

2020 journal article

Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 690.

author keywords: Alkaptonuria; Osteoblast; Oxidative stress; Nrf2; Mitochondria; NADPH oxidase
MeSH headings : Alkaptonuria / metabolism; Cell Line; DNA-Binding Proteins / metabolism; Homeostasis / physiology; Homogentisic Acid / metabolism; Humans; Hydrogen Peroxide / metabolism; Mitochondria / metabolism; Mitochondria / ultrastructure; NADPH Oxidases / metabolism; NF-E2-Related Factor 2 / metabolism; Osteoblasts / cytology; Oxidation-Reduction; Oxidative Stress / physiology; Signal Transduction; Superoxide Dismutase / metabolism; Thioredoxins / metabolism
TL;DR: HGA is able to alter the cellular redox homeostasis by modulating the endogenous ROS production via NOX activation and mitochondrial dysfunctions and impair the cellular response mechanism, which can be useful for understanding the pathophysiology of AKU. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021

2020 review

Mimicking cigarette smoke exposure to assess cutaneous toxicity

[Review of ]. TOXICOLOGY IN VITRO, 62.

By: R. Prieux*, M. Eeman, B. Rothen-Rutishauser* & G. Valacchi n

author keywords: Cigarette smoke; Skin models; Inflammation; Oxidative stress; Psoriasis; Atopic dermatitis
MeSH headings : Animals; Humans; Skin / drug effects; Skin Diseases / chemically induced; Tobacco Products; Tobacco Smoke Pollution / adverse effects
TL;DR: An update is provided on the skin models currently available to study cigarette smoke exposure and the known pathways involved in cutaneous toxicity and the inflammatory skin pathologies potentially induced and/or exacerbated by cigarette smoke Exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019

2020 journal article

Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 30(2), 112–119.

By: D. Nieman*, G. Valacchi*, L. Wentz*, F. Ferrara*, A. Pecorelli*, B. Woodby*, C. Sakaguchi*, A. Simonson*

author keywords: inflammation exercise; oxidative stress; peripheral blood mononuclear cells
TL;DR: Flavonoid supplementation prior to intensive exercise decreased plasma peroxidation and oxidative damage, as determined by 4-hydroxynonenal. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2020 journal article

NADPH oxidase and mitochondria are relevant sources of superoxide anion in the oxinflammatory response of macrophages exposed to airborne particulate matter

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 205.

By: L. Caceres*, M. Paz*, M. Garces*, V. Calabro*, N. Magnani*, M. Martinefski*, P. Adami*, L. Caltana* ...

author keywords: Air pollution; Oxidative stress; Inflammation; Mitochondria; NADPH oxidase; Macrophages
MeSH headings : Air Pollutants / toxicity; Animals; Antioxidants / metabolism; Coal Ash / toxicity; Hydrogen Peroxide / metabolism; Inflammation; Macrophages, Alveolar / drug effects; Macrophages, Alveolar / immunology; Macrophages, Alveolar / metabolism; Mice; Mitochondria / drug effects; Mitochondria / immunology; Mitochondria / metabolism; NADPH Oxidases / metabolism; Oxidation-Reduction; Oxidative Stress / drug effects; Oxidative Stress / immunology; Particulate Matter / toxicity; RAW 264.7 Cells; Superoxides / metabolism; Tumor Necrosis Factor-alpha / metabolism
TL;DR: The results indicate that PM exposure induces direct activation of macrophages, leading to inflammation and increased reactive oxygen species production through NOX and mitochondria, which impairs antioxidant defense and may cause mitochondrial dysfunction. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 16, 2020

2020 journal article

Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid

NANOMATERIALS, 10(5).

By: M. Sguizzato*, P. Mariani*, F. Ferrara*, M. Drechsler*, S. Hallan*, N. Huang*, F. Simeliere*, N. Khunti* ...

author keywords: solid lipid nanoparticles; caffeic acid; poloxamer; small angle X-ray scattering; cigarette smoke
TL;DR: The antioxidant effect of caffeic acid loaded in nanoparticulate gel has been demonstrated by ex-vivo evaluation on human skin explants exposed to cigarette smoke, suggesting a protective role exerted by the nanoparticles. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

2020 journal article

Particulate Matter Induces Tissue OxInflammation: From Mechanism to Damage

ANTIOXIDANTS & REDOX SIGNALING, 33(4), 308–326.

By: G. Valacchi n, N. Magnani*, B. Woodby n, S. Maria Ferreira & P. Evelson*

author keywords: oxidative stress; inflammation; particulate matter; air pollution
MeSH headings : Air Pollution / adverse effects; Animals; Cytokines / metabolism; Disease Susceptibility; Humans; Inflammation / etiology; Inflammation / metabolism; Inflammation / pathology; Inflammation Mediators / metabolism; Oxidation-Reduction; Oxidative Stress; Particulate Matter / adverse effects; Reactive Oxygen Species / metabolism
TL;DR: Research is required to elucidate the exact mechanisms by which PM exposure results in adverse health effects, in terms of the relationship between the redox responses triggered by the presence of the particles and the inflammation observed in the different organs, so the development/exacerbation of PM-associated health problems can be prevented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

2020 journal article

Postexercise Inflammasome Activation and IL-1 beta Production Mitigated by Flavonoid Supplementation in Cyclists

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 30(6), 396–404.

By: D. Nieman*, F. Ferrara*, A. Pecorelli*, B. Woodby*, A. Hoyle*, A. Simonson*, G. Valacchi*

author keywords: cytokines; gasdermin D; IL-18; inflammation
TL;DR: The data indicate that 2-week FLAV ingestion mitigated inflammasome activation, with a corresponding decrease in IL-1β release in cyclists after a 75-km cycling time trial, and support the strategy of ingesting high amounts of FLAV to mitigate postexercise inflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2020 journal article

Proteomic pro fi ling reveals mitochondrial alterations in Rett syndrome

FREE RADICAL BIOLOGY AND MEDICINE, 155, 37–48.

By: V. Cicaloni*, A. Pecorelli n, L. Tinti*, M. Rossi*, M. Benedusi*, C. Cervellati*, O. Spiga*, A. Santucci* ...

MeSH headings : Gene Expression Profiling; Humans; Methyl-CpG-Binding Protein 2 / genetics; Mutation; Proteome / genetics; Proteomics; Rett Syndrome / genetics
TL;DR: The proteomic analysis confirms the pathological relevance of mitochondrial dysfunction in RTT pathogenesis and progression and carries out the first comprehensive characterization of RTT cellular proteome, showing mainly changes in expression of proteins involved in the mitochondrial network. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2020 journal article

Redox regulation of cutaneous inflammasome by ozone exposure

FREE RADICAL BIOLOGY AND MEDICINE, 152, 561–570.

By: F. Ferrara*, E. Pambianchi*, A. Pecorelli*, B. Woodby*, N. Messano*, J. Therrien, M. Lila*, G. Valacchi*

MeSH headings : Caspase 1 / metabolism; Humans; Hydrogen Peroxide; Inflammasomes / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidation-Reduction; Ozone / toxicity; Reactive Oxygen Species
TL;DR: It is demonstrated that O3 can activate cutaneous inflammasome in a redox dependent manner suggesting a possible role of this new pathway in pollution induced inflammatory skin conditions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

2020 journal article

Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer's disease

GEROSCIENCE, 42(1), 159–167.

By: C. Cervellati*, A. Trentini*, V. Rosta*, A. Passaro*, C. Bosi*, J. Sanz*, S. Bonazzi*, S. Pacifico* ...

author keywords: Late-onset Alzheimer's disease; Mild cognitive impairment; Mixed dementia; Blood-based biomarkers; BACE1
MeSH headings : Alzheimer Disease / diagnosis; Amyloid Precursor Protein Secretases; Amyloid beta-Peptides; Aspartic Acid Endopeptidases; Biomarkers; Humans
TL;DR: The data suggest that increased BACE1 activity in serum may represent a potential biomarker for LOAD, and additional studies are needed to confirm the usefulness of Bace1, alone or in combination with other markers, in discriminating patients and predicting LOAD onset and progression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 16, 2020

2020 article

Skin Health from the Inside Out

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 235–254.

By: B. Woodby n, K. Penta n, A. Pecorelli n, M. Lila n & G. Valacchi n

author keywords: pollution; skin; diet; GI tract; inflammation; antioxidant; vitamins
MeSH headings : Antioxidants / metabolism; Humans; Reactive Oxygen Species / metabolism; Skin Physiological Phenomena
TL;DR: This review discusses how topical application of antioxidants, including vitamins C and E, carotenoids, resveratrol, and pycnogenol, can be combined with dietary supplementation of these antioxidant compounds in addition to probiotics and essential minerals to protect against outdoor stressor-induced skin damage, including the damage associated with aging. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2020 journal article

The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 685.

By: B. Woodby n, C. Sticozzi*, E. Pambianchi n, G. Villetti, M. Civelli, G. Valacchi n, F. Facchinetti

author keywords: NOX; NF-kappa B; Cyclin D1; Skin; p21
MeSH headings : Aldehydes / metabolism; Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin D1 / metabolism; Humans; Keratinocytes / drug effects; Lipid Peroxidation / drug effects; NADPH Oxidases / metabolism; Oxidative Stress / drug effects; Phosphodiesterase 4 Inhibitors / pharmacology; Phosphodiesterase 4 Inhibitors / toxicity; Psoriasis / drug therapy; Sulfonamides / pharmacology; Sulfonamides / toxicity; Transcription Factor RelA / metabolism; para-Aminobenzoates / pharmacology; para-Aminobenzoates / toxicity
TL;DR: CHF6001 has the potential to treat skin disorders associated with hyperproliferative keratinocytes, such as psoriasis by targeting oxidative stress, abnormal re-epithelization, and inflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020

2019 journal article

13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation

FREE RADICAL BIOLOGY AND MEDICINE, 134, 598–603.

By: A. Pecorelli n, C. Cervellati*, V. Cordone n, F. Amicarelli*, J. Hayek* & G. Valacchi n

author keywords: Rett syndrome; Oxidative stress; Hydroxyoctadecadienoic acids; Inflammation; Omega-3 polyunsaturated fatty acids; Arachidonate 15-Lipoxygenase
MeSH headings : Adolescent; Adult; Arachidonate 15-Lipoxygenase / genetics; Arachidonate 15-Lipoxygenase / metabolism; Case-Control Studies; Child; Female; Humans; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Leukocytes, Mononuclear / metabolism; Linoleic Acids / metabolism; Linoleic Acids, Conjugated / metabolism; Male; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology; Young Adult
TL;DR: Statistically significant correlation was demonstrated between the increased plasma HODEs levels and the lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, and the possible ability of omega-3 polyunsaturated fatty acids supplementation in improving the oxinflammation status in RTT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 1, 2019

2019 journal article

Antiglycative Activity and RAGE Expression in Rett Syndrome

CELLS, 8(2).

By: V. Cordone*, A. Pecorelli n, M. Benedusi*, S. Santini*, S. Falone*, J. Hayek*, F. Amicarelli*, G. Valacchi n

author keywords: methylglyoxal; glyoxalases; advanced glycation end products; MeCP2; dicarbonyl stress; fibroblasts
MeSH headings : Adolescent; Adult; Antigens, Neoplasm / metabolism; Cell Survival / drug effects; Child; Female; Fibroblasts / drug effects; Fibroblasts / metabolism; Glycosylation; Humans; Lactoylglutathione Lyase / metabolism; Mitogen-Activated Protein Kinases / metabolism; Pyruvaldehyde / pharmacology; Rett Syndrome / metabolism; Rett Syndrome / pathology; Thiolester Hydrolases / metabolism; Young Adult
TL;DR: Besides OxInflammation, RTT is associated with reshaping of the major defense systems against dicarbonyl stress, along with an altered cellular stress response towards pro-glycating insults. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2019

2019 article

Blueberries Topical Application Prevents Ozone Induced Cutaneous Inflammasome Activation

Pambianchi, E., Francesca, F., Pecorelli, A., Woodby, B., Lila, M., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S148–S148.

By: E. Pambianchi, F. Francesca, A. Pecorelli, B. Woodby, M. Lila & G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 journal article

Bone status in relation to ambulatory performance in girls with Rett syndrome: a 10-year longitudinal study

PEDIATRIC RESEARCH, 85(5), 639–643.

By: C. Caffarelli*, V. Francolini n, J. Hayek*, G. Valacchi*, S. Giannotti*, R. Nuti*, S. Gonnelli*

MeSH headings : Absorptiometry, Photon; Adolescent; Bone Density; Bone and Bones / diagnostic imaging; Bone and Bones / physiology; Child; Child Nutrition Sciences; Child, Preschool; Cholecalciferol / administration & dosage; Disabled Persons; Female; Finger Phalanges / diagnostic imaging; Follow-Up Studies; Fractures, Bone / diagnostic imaging; Humans; Infant; Longitudinal Studies; Nutritional Status; Rett Syndrome / diagnostic imaging; Rett Syndrome / physiopathology; Surveys and Questionnaires; Ultrasonography; Vitamin D / blood; Walking
TL;DR: This longitudinal study suggests that both ambulatory and nonambulatory Rett subjects present a progressive deterioration of bone status as assessed by quantitative ultrasound parameters, and the ambulatory impairment and the nutritional status seem to play a key role in the deterioration ofBone status. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 9, 2019

2019 article

Comparing Skin Aging in Vitro Induced by External and Internal Cigarette Smoke Exposure

Prieux, R., Valacchi, G., Benedusi, M., & Cervellati, F. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S137–S137.

By: R. Prieux, G. Valacchi, M. Benedusi & F. Cervellati

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 journal article

Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P-aeruginosa Clinical Strains

JOURNAL OF CHEMISTRY, 2019.

By: D. Bortolotti*, C. Trapella*, A. Bragonzi*, P. Marchetti*, V. Zanirato*, A. Alogna*, V. Gentili*, C. Cervellati* ...

TL;DR: This work has identified, for the first time, a QSi conjugated with ciprofloxacin (ET37), that is able to reduce the formation of biofilm and the onset of tolerant clones in P. aeruginosaclinical strains and could have a wide application in clinical setting. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 9, 2019

2019 journal article

Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 183.

By: A. Grillo*, G. Chemi*, S. Brogi*, M. Brindisi*, N. Relitti*, F. Fezza*, D. Fazio*, L. Castelletti* ...

author keywords: Endocannabinoid system; Fatty acid amide hydrolase; Enzyme inhibitors; Selective inhibitors; Dopamine ligands; Polypharmacology; Multitarget compounds; Dopamine receptor ligands
MeSH headings : Amidohydrolases / antagonists & inhibitors; Amidohydrolases / metabolism; Binding, Competitive; Cell Line; Cell Survival / drug effects; Dopamine / metabolism; Endocannabinoids / metabolism; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Humans; Ligands; Piperazines / chemistry; Piperazines / pharmacology; Pyrroles / chemistry; Pyrroles / pharmacology
TL;DR: The synthesis and biological characterization of compounds 5a-j inspired by the structure of the authors' potent and selective fatty acid amide hydrolase (FAAH) inhibitors and ligands of dopamine D2 or D3 receptor subtypes are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 16, 2019

2019 review

Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development

[Review of ]. MINERVA MEDICA, 110(3), 238–250.

author keywords: PON1 protein, human; Alzheimer's disease; Oxidative stress
MeSH headings : Alzheimer Disease / blood; Alzheimer Disease / epidemiology; Alzheimer Disease / etiology; Aryldialkylphosphatase / blood; Humans
TL;DR: The possible link between PON1 with AD pathogenesis is discussed, eventual mechanistic pathways that could account from epidemiological observations are hypothesized and the methodological issue limitation in Pon1 studies is highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 6, 2019

2019 article

HGA Induces Oxidative Damage in an Ostcoblastic Cellular Model of Alkaptonuria: Sources and Mechanisms HGA Induces Oxidative Damage in an Osteoblastic Cellular Model of Alkaptonuria: Sources and Mechanisms

Schiavone, M. L., Pecorelli, A., Woodby, B., Ferrara, F., Santucci, A., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S37–S38.

By: M. Schiavone, A. Pecorelli, B. Woodby, F. Ferrara, A. Santucci & G. Valacchi

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 review

Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage

[Review of ]. BIOFACTORS, 45(4), 536–547.

By: A. Pecorelli n, B. Woodby n, R. Prieux* & G. Valacchi n

author keywords: ozone; particulate matter; cigarette smoke; peroxidation
MeSH headings : Air Pollutants / metabolism; Air Pollutants / toxicity; Aldehydes / metabolism; Aldehydes / toxicity; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / genetics; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Gene Expression Regulation / drug effects; Humans; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Oxidation-Reduction; Oxidative Stress; Ozone / metabolism; Ozone / toxicity; Particulate Matter / toxicity; Psoriasis / chemically induced; Psoriasis / genetics; Psoriasis / metabolism; Psoriasis / pathology; Reactive Oxygen Species / agonists; Reactive Oxygen Species / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Aging / drug effects; Skin Aging / genetics; Skin Aging / pathology; Tobacco Smoke Pollution / adverse effects; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: Increased levels of HNE in the skin, in response to pollutants, likely accelerates skin aging and exacerbates existing skin inflammatory conditions; thus, targeting HNE formation could be an innovative cosmeceutical approach for topical applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2019 journal article

Involvement of cutaneous SR-B1 in skin lipid homeostasis

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 666, 1–7.

By: X. Muresan*, M. Narzt*, B. Woodby n, F. Ferrara n, F. Gruber & G. Valacchi n

author keywords: Scavenger receptor; Skin; Keratinocytes; Lipids; Ceramides; Cholesterol; Differentiation
MeSH headings : Cell Differentiation / physiology; Cells, Cultured; Filaggrin Proteins; Gene Expression Regulation; Homeostasis; Humans; Keratinocytes / cytology; Lipid Metabolism / genetics; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / physiology; Skin / cytology; Skin / metabolism
TL;DR: One of the main functions of SR-B1 in the skin is to regulate ceramide levels and thereby maintain the barrier function of the skin, resulting in the protection of cutaneous tissues from outdoor insults. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019

2019 journal article

Involvement of the TREK-1 channel in human alveolar cell membrane potential and its regulation by inhibitors of the chloride current

JOURNAL OF CELLULAR PHYSIOLOGY, 234(10), 17704–17713.

By: R. Canella*, M. Martini*, C. Cavicchio, F. Cervellati*, M. Benedusi* & G. Valacchi*

author keywords: 9-AC; A549 cells; ANO-6; DCPIB; K plus channels; pneumocytes
MeSH headings : A549 Cells; Alveolar Epithelial Cells / metabolism; Biological Transport / physiology; Cell Line, Tumor; Cell Membrane / metabolism; Cell Size; Chloride Channels / metabolism; Chlorides / metabolism; Humans; Membrane Potentials / physiology; Patch-Clamp Techniques / methods; Potassium Channels, Tandem Pore Domain / metabolism
TL;DR: The identification of DCPIB and 9‐AC molecules as its activators suggests their possible use to build new pharmacological tools for the modulation of this channel and identifies the TREK‐1 channel as the presumable target of both drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 29, 2019

2019 journal article

Lipid nanostructures for antioxidant delivery: a comparative preformulation study

BEILSTEIN JOURNAL OF NANOTECHNOLOGY, 10, 1789–1801.

author keywords: alpha-tocopherol; cryogenic transmission electron microscopy (cryo-TEM); dermocosmetics; HO-1; nanostructured lipid carriers (NLCs); retinoic acid; skin pollution; solid lipid nanoparticles (SLNs)
TL;DR: Interestingly, it was found that pretreatment with the nanoformulation resulted in significantly reduced heme oxygenase upregulation as compared to control samples, suggesting a protective effect provided by the nanoparticles. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 16, 2019

2019 journal article

Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells

BIOFACTORS, 45(6), 920–929.

By: F. Ietta*, G. Valacchi*, L. Benincasa*, A. Pecorelli*, L. Cresti* & E. Maioli*

author keywords: apoptosis; ER stress; melanoma; mitochondria; protein synthesis; rottlerin
TL;DR: In this cell line, rottlerin exhibits its main and newest cytotoxic properties, that is, growth arrest, apoptosis induction, and translation shutoff, and the drug markedly inhibited cell proliferation through cyclin D1 downregulation and induced apoptotic cell death as early as after 18 h treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019

2019 article

OxInflammation as a Aossible new Player in Rett Syndrome Pathophysiology

Pecorelli, A., Valacchi, G., Cordone, V., & Hayek, J. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S149–S149.

By: A. Pecorelli, G. Valacchi, V. Cordone & J. Hayek

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 review

Ozonated Oils and Cutaneous Wound Healing

[Review of ]. CURRENT PHARMACEUTICAL DESIGN, 25(20), 2264–2278.

By: Y. Lim*, H. Lee*, B. Woodby n & G. Valacchi*

author keywords: Cutaneous wound healing; ROS; peroxidation; topical application; ozonated oil; inflammation
MeSH headings : Humans; Ozone; Phytotherapy; Plant Oils / therapeutic use; Skin; Wound Healing
TL;DR: The present review intends to summarize the actual state of the art of the topical usage of ozonated oil in cutaneous wounds with special emphasis to the importance of theozonated degree of the oil. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 7, 2019

2019 article

Redox Regulation of Cutaneous Inflammasome Pathway by Ozone Exposure

Ferrara, F., Pecorelli, A., Woodby, B., Pambianchi, E., Messano, N., Therrien, J. P., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S22–S23.

By: F. Ferrara, A. Pecorelli, B. Woodby, E. Pambianchi, N. Messano, J. Therrien, G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox-Regulation of Antimicrobial Peptides

Woodby, B., Pambianchi, E., Francesca, F., Messano, N., Pecorelli, A., Therrien, J. P., & Valacchii, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S54–S55.

By: B. Woodby, E. Pambianchi, F. Francesca, N. Messano, A. Pecorelli, J. Therrien, G. Valacchii

UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 journal article

Skin damage by tropospheric ozone

HAUTARZT, 70(3), 163–168.

By: K. Fuks*, B. Woodby n & G. Valacchi n

author keywords: Air pollution; Skin aging; Skin wrinkling; Oxidative stress; Peroxidation
MeSH headings : Air Pollutants / adverse effects; Air Pollution; Humans; Lipid Peroxidation / drug effects; Nitrogen Dioxide / analysis; Oxidative Stress; Ozone / adverse effects; Ozone / analysis; Particulate Matter / analysis; Public Health; Skin Aging / drug effects; Skin Aging / radiation effects; Ultraviolet Rays / adverse effects
TL;DR: The experimental evidence suggests a positive correlation of O3 exposure with oxidative damage, impaired antioxidant defence and proinflammatory response in the skin, and skin might be a potentially overlooked target organ of ambient O3. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2019

2019 journal article

Trehalose inhibits cell proliferation and amplifies long-term temozolomide- and radiation-induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence

JOURNAL OF CELLULAR PHYSIOLOGY, 234(7), 11708–11721.

By: G. Allavena*, B. Del Bello*, P. Tini*, N. Volpi*, G. Valacchi*, C. Miracco*, L. Pirtoli*, E. Maellaro*

author keywords: melanoma cells; trehalose; autophagy; premature senescence; radiosensitization
MeSH headings : Apoptosis / drug effects; Apoptosis / radiation effects; Autophagy / drug effects; Autophagy / radiation effects; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Proliferation / radiation effects; Cellular Senescence / drug effects; Cellular Senescence / radiation effects; Chloroquine / pharmacology; Drug Resistance, Neoplasm / drug effects; Humans; Melanocytes / drug effects; Melanocytes / metabolism; Melanocytes / pathology; Melanocytes / radiation effects; Melanoma / pathology; Melanoma / radiotherapy; Radiation, Ionizing; Sequestosome-1 Protein / metabolism; Temozolomide / pharmacology; Trehalose / pharmacology
TL;DR: The results suggest that trehalose, a safe nutrient supplement able to cross the blood–brain barrier, is a promising candidate, worthy to be further explored in vivo, to augment the therapeutic efficacy of TMZ and RT in melanoma brain metastases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 22, 2019

2018 article

AtmO(3)spheric skin damage: The oxInflammation phenomena

Valacchi, G., Pecorelli, A., Pambianchi, E., Ferrara, F., & Lila, M. (2018, September). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 138, pp. B15–B15.

By: G. Valacchi n, A. Pecorelli*, E. Pambianchi*, F. Ferrara n & M. Lila*

Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2018 journal article

Circadian clock as possible protective mechanism to pollution induced keratinocytes damage

Mechanisms of Ageing and Development, 172, 13–20.

By: M. Benedusi*, E. Frigato*, M. Beltramello*, C. Bertolucci* & G. Valacchi*

author keywords: Ozone (O-3); Oxidative stress; Circadian clock; Antioxidant pathway; Skin homeostasis
MeSH headings : ARNTL Transcription Factors / metabolism; Air Pollutants / toxicity; Cell Line; Circadian Clocks; Gene Expression Regulation / drug effects; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; NF-E2-Related Factor 2 / metabolism; Organ Specificity; Ozone / toxicity; Skin / metabolism; Skin / pathology
TL;DR: This work investigated a possible protective role of entrained circadian clock to ozone induced damage in keratinocytes, the main cellular component of human epidermis, and showed that clock-synchronized keratinocyte compared to arrhythmic ones exhibited a more efficient antioxidant response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 journal article

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain

ChemMedChem, 13(19), 2090–2103.

By: M. Brindisi*, G. Borrelli*, S. Brogi*, A. Grillo*, S. Maramai*, M. Paolino*, M. Benedusi*, A. Pecorelli n ...

author keywords: covalent inhibitors; endocannabinoid system; fatty acid amide hydrolase; neuropathic pain; serine hydrolase
MeSH headings : Amidohydrolases / antagonists & inhibitors; Animals; Benzodiazepinones / chemical synthesis; Benzodiazepinones / pharmacology; Benzodiazepinones / therapeutic use; Benzodiazepinones / toxicity; Cell Line, Tumor; Enzyme Inhibitors / chemical synthesis; Enzyme Inhibitors / pharmacology; Enzyme Inhibitors / therapeutic use; Enzyme Inhibitors / toxicity; Humans; Male; Mice; Molecular Docking Simulation; Molecular Structure; NF-kappa B / metabolism; Neuralgia / drug therapy; Oxidative Stress / drug effects; Structure-Activity Relationship
TL;DR: A series of 12 new compounds characterized by functionalized tricyclic scaffolds developed, showing the ability to decrease oxidative stress by reducing the expression of the redox‐sensitive transcription factor NF‐κB and able to relieve the hypersensitivity induced by oxaliplatin. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 article

Inflammasome involvement in Rett syndrome subclinical inflammation

Pecorelli, A., Cordone, V., Falone, S., Romani, A., Benedusi, M., Hayek, J., … Valacchi, G. (2018, November 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 128, pp. S108–S109.

By: A. Pecorelli n, V. Cordone*, S. Falone*, A. Romani*, M. Benedusi*, J. Hayek*, F. Amicarelli*, G. Valacchi n

TL;DR: The results suggest a possible basal activation of inflammasome in RTT cells that, on the other hand, appear to be unable to respond properly at the inflammatory stimulus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 19, 2018

2018 journal article

Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure

MECHANISMS OF AGEING AND DEVELOPMENT, 172, 86–95.

By: A. Romani*, C. Cervellati*, X. Muresan*, G. Belmonte*, A. Pecorelli n, F. Cervellati*, M. Benedusi*, P. Evelson*, G. Valacchi n

author keywords: Air pollution; Particulate matter; Oxidative damage; Inflammation
MeSH headings : Cell Line, Transformed; Humans; Interleukin-1alpha / metabolism; Keratinocytes / metabolism; Keratinocytes / pathology; NF-E2-Related Factor 2 / metabolism; NF-kappa B / metabolism; Oxidation-Reduction / drug effects; Particulate Matter / toxicity
TL;DR: Overall these data, suggest lipid and protein oxidative damage, as well as an increase of inflammatory response after being challenged with CAPs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Lifestyle determinants of healthy ageing in a Mediterranean population: The multinational MEDIS study

Experimental Gerontology, 110, 35–41.

By: A. Foscolou*, E. Magriplis*, S. Tyrovolas*, G. Soulis*, V. Bountziouka*, A. Mariolis, S. Piscopo*, G. Valacchi* ...

author keywords: Healthy ageing; Longevity; Elderly; Health policy; Mediterranean
MeSH headings : Aged; Aged, 80 and over; Cardiovascular Diseases / epidemiology; Diet, Mediterranean; Exercise; Feeding Behavior; Female; Healthy Aging; Humans; Logistic Models; Longevity; Male; Mediterranean Region / epidemiology; Risk Factors; Smoking / epidemiology
TL;DR: The gaps in the understanding of factors affecting longevity and healthy ageing remain; public health authorities and stakeholders should focus on the lifestyle determinants of healthy ageing, that seems to be an effective mean for improving older peoples' health. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 journal article

Low-grade systemic inflammation is associated with functional disability in elderly people affected by dementia

GeroScience, 40(1), 61–69.

author keywords: Inflammation; Dementia; Alzheimer's disease; Mixed dementia; Functional abilities
MeSH headings : Activities of Daily Living; Aged; Aged, 80 and over; Aging / physiology; Alzheimer Disease / etiology; Alzheimer Disease / physiopathology; Analysis of Variance; C-Reactive Protein / metabolism; Case-Control Studies; Cognitive Dysfunction / etiology; Cognitive Dysfunction / physiopathology; Dementia / complications; Dementia / diagnosis; Disability Evaluation; Disease Progression; Female; Geriatric Assessment / methods; Homocysteine / metabolism; Humans; Inflammation / complications; Inflammation / diagnosis; Italy; Male; Reference Values; Retrospective Studies
TL;DR: The data suggest that systemic low-grade inflammation may contribute to functional disability in older patients with dementia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
2. Zero Hunger (Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 journal article

Mediterranean diet and depression among older individuals: The multinational MEDIS study

Experimental Gerontology, 110, 67–72.

By: M. Masana*, J. Haro*, A. Mariolis, S. Piscopo*, G. Valacchi*, V. Bountziouka*, F. Anastasiou*, A. Zeimbekis ...

author keywords: Mediterranean diet; Tea; Depression; Older adults
MeSH headings : Aged; Aged, 80 and over; Cross-Sectional Studies; Depression / epidemiology; Diet, Mediterranean; Female; Geriatric Assessment; Humans; Life Style; Logistic Models; Male; Mediterranean Region / epidemiology; Psychiatric Status Rating Scales; Risk Factors; Self Report; Tea
TL;DR: Greater adherence to the MedDiet and daily tea drinking seem to have a beneficial effect on depressive symptoms in older adults. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 journal article

Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs “in vitro” wound closure

Mechanisms of Ageing and Development, 172, 78–85.

By: X. Muresan*, C. Sticozzi*, G. Belmonte*, V. Savelli*, P. Evelson* & G. Valacchi n

author keywords: Skin; Oxidative stress; Pollution; RHE; Wound healing; Particulate matter; Cigarette smoke; Ozone
MeSH headings : Cell Line, Transformed; Epidermis / metabolism; Epidermis / pathology; Gene Expression Regulation; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Scavenger Receptors, Class B / biosynthesis; Tobacco Smoke Pollution / adverse effects; Wound Healing
TL;DR: The data obtained showed that not only cigarette, but also the other environmental stressors reduced SR-B1 expression in epidermal cutaneous tissues and that this effect might be involved in impaired wound healing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 journal article

Non-conventional rottlerin anticancer properties

Archives of Biochemistry and Biophysics, 645, 50–53.

By: E. Maioli*, E. Daveri*, E. Maellaro*, F. Ietta*, L. Cresti* & G. Valacchi*

MeSH headings : Acetophenones / pharmacology; Acetophenones / therapeutic use; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Benzopyrans / pharmacology; Benzopyrans / therapeutic use; Breast Neoplasms / drug therapy; Humans; Melanoma / drug therapy
TL;DR: The major novelties highlighted in this mini review are the ability to bind and inhibit key molecules, such as ERK and mTOR, directly, thus independently of upstream signaling cascades, and to cause a profound dysregulation of cap-dependent protein translation through the mTORC1/4EBP1/eIF4E axis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 journal article

OXINFLAMMATION IN RETT SYNDROME

Pathophysiology, 25(3), 189.

By: G. Valacchi n, A. Pecorelli n & C. Cervellati*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 review

OxInflammation: From Subclinical Condition to Pathological Biomarker

[Review of ]. FRONTIERS IN PHYSIOLOGY, 9.

By: G. Valacchi n, F. Virgili*, C. Cervellati* & A. Pecorelli n

author keywords: biomarkers; neurological disorders; oxidative stress; inflammation mediators; NF kappa B
TL;DR: The term “OxInflammation” is proposed as a novel operative term describing a permanent pro-oxidative feature that interact, in a positive feed-back manner, to a not yet clinically detectable inflammatory process, leading in a long run (chronically) to a systemic/local damage, as a consequence of the cross talk between inflammatory, and oxidative stress mediators. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Role of Nrf2 in preventing oxidative stress induced chloride current alteration in human lung cells

Journal of Cellular Physiology, 233(8), 6018–6027.

By: R. Canella*, M. Benedusi*, M. Martini*, F. Cervellati*, C. Cavicchio* & G. Valacchi*

author keywords: catalase; chloride current; ozone; patch clamp; redox imbalance; respiratory tract
MeSH headings : A549 Cells; Antioxidants / metabolism; Catalase / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cell Survival / physiology; Chloride Channels / metabolism; Chlorides / metabolism; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Gene Expression Regulation / drug effects; Gene Expression Regulation / physiology; Humans; Hydrogen Peroxide / pharmacology; Lung / drug effects; Lung / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / physiology; Ozone / pharmacology
TL;DR: Patch clamp experiments bring new insights into the mechanisms involved in OS‐induced lung tissue damage, pointing out the role of H2O2 in chloride current alteration and the ability of Nfr2 activation in preventing this effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2018 journal article

SR-B1 involvement in keratinocytes in vitro wound closure

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 658, 1–6.

By: X. Muresan*, C. Sticozzi*, G. Belmonte*, F. Cervellati*, F. Ferrara*, M. Lila n, G. Valacchi n

author keywords: Wound healing; Skin; Proliferation; Migration
MeSH headings : Cell Line, Transformed; Cell Movement / physiology; Cell Proliferation / physiology; Cyclin D1 / metabolism; Gene Knockout Techniques; Humans; Keratinocytes / cytology; Keratinocytes / physiology; Matrix Metalloproteinase 9 / metabolism; NF-kappa B p50 Subunit / metabolism; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / physiology; Skin / metabolism; Wound Healing / physiology
TL;DR: In vitro data demonstrated that SR-B1 influenced keratinocyte proliferation and migration through a downregulation of nuclear cyclin D1 levels and active MMP9 expression respectively possibly in an NF-kB-dependent mechanism, and suggests a new role of SRB1 as a possible new key player in cutaneous wound healing mechanism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 26, 2018

2018 article

Scavenger receptor B1 as a possible new player in cutaneous tissue proliferation and differentiation

Valacchi, G., Muresan, X., Belmonte, G., Pecorelli, A., & Gruber, F. (2018, September). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 138, pp. B25–B25.

By: G. Valacchi n, X. Muresan, G. Belmonte*, A. Pecorelli & F. Gruber

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2018 journal article

Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells

FREE RADICAL BIOLOGY AND MEDICINE, 126, 287–295.

By: C. Sticozzi*, A. Pecorelli*, A. Romani*, G. Belmonte*, F. Cervellati*, E. Maioli*, M. Lila*, C. Gervellati, G. Valacchi*

MeSH headings : A549 Cells; Aldehydes / metabolism; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Antioxidants / pharmacology; Biological Transport / drug effects; Catalase / genetics; Catalase / metabolism; Cell Survival / drug effects; Humans; Hydrogen Peroxide / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Oxidation-Reduction / drug effects; Oxidative Stress / drug effects; Ozone / pharmacology; Protein Processing, Post-Translational / drug effects; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / metabolism; Vitamin E / metabolism
TL;DR: To characterize the molecular mechanism involved in the redox modulation of SRB1, its cellular levels were assessed in human alveolar epithelial cells after O3 exposure and it was demonstrated that O3 induced the loss ofSRB1 protein levels, a mechanism that could account for SRB 1 protein loss. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018

2017 review

4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation

[Review of ]. FREE RADICAL BIOLOGY AND MEDICINE, 111, 270–280.

By: G. Valacchi n, A. Pecorelli n, C. Cervellati* & J. Hayek*

author keywords: Inflammation; Isoprostanes; Oxidative stress; Rare disease; Orphan disease; CDKL5; FOXG1; MecP2
MeSH headings : Aldehydes / metabolism; Brain / metabolism; Brain / pathology; Feedback, Physiological; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Humans; Inflammation; Isoprostanes / metabolism; Lipid Peroxidation / genetics; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mutation; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Oxidative Stress; Proteasome Endopeptidase Complex / metabolism; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology
TL;DR: Aiming 4HNE as a therapeutic target could represent a coadjuvant treatment with some beneficial impact in these patients, in a pathology completely orphan of any therapy, with special emphasis on 4-hydroxynonenal (4HNE). (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

First dual AK/GSK-3 beta inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 138, 438–457.

By: S. Brogi*, A. Ramunno*, L. Savi*, G. Chemi*, G. Alfano*, A. Pecorelli n, E. Pambianchi n, P. Galatello* ...

author keywords: Antioxidant agents; Glycogen synthase kinase 3 beta (GSK-3 beta); Adenosine kinase (AK); Dual inhibitors; Molecular docking
MeSH headings : Adenosine Kinase / antagonists & inhibitors; Adenosine Kinase / metabolism; Antioxidants / chemical synthesis; Antioxidants / chemistry; Antioxidants / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Humans; Hydrogen Peroxide / antagonists & inhibitors; Hydrogen Peroxide / pharmacology; Molecular Structure; Neuroblastoma / metabolism; Neuroblastoma / pathology; Neuroprotective Agents / chemical synthesis; Neuroprotective Agents / chemistry; Neuroprotective Agents / pharmacology; Oxidative Stress / drug effects; Protein Kinase Inhibitors / chemical synthesis; Protein Kinase Inhibitors / chemistry; Protein Kinase Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Structure-Activity Relationship
TL;DR: The identification of compound 5l, as the first dual hAK/hGSK-3β inhibitor reported to date, holds promise for the development of new series of potential therapeutic agents for the treatment of neurodegenerative diseases characterized by an innovative pharmacological profile. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Is car use related with successful aging of older adults? Results from the multinational Mediterranean islands study

Annals of Epidemiology, 27(3), 225–229.

By: S. Tyrovolas*, E. Polychronopoulos*, M. Morena*, A. Mariolis, S. Piscopo*, G. Valacchi*, V. Bountziouka*, F. Anastasiou* ...

author keywords: Successful aging; Car use; Driving; Mediterranean islands; Older adults
MeSH headings : Aged; Aged, 80 and over; Aging / physiology; Aging / psychology; Automobile Driving / psychology; Automobile Driving / statistics & numerical data; Cross-Sectional Studies; Female; Greece; Humans; Male; Mediterranean Islands; Quality of Life / psychology; Rural Population / statistics & numerical data
TL;DR: The activity of car use seems to be an indicator of quality of life among older adults, as measured through successful aging, as well as less prevalence of obesity and hypertension while were more physically active. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2017 journal article

Mediterranean lifestyle and cardiovascular disease prevention

Cardiovascular Diagnosis and Therapy, 7, S39–47.

By: E. Georgousopoulou, D. Mellor, N. Naumovski, E. Polychronopoulos, S. Tyrovolas, S. Piscopo, G. Valacchi, F. Anastasiou ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Modulation of Chloride Currents in Human Lung Epithelial Cells Exposed to Exogenous Oxidative Stress

JOURNAL OF CELLULAR PHYSIOLOGY, 232(7), 1817–1825.

By: R. Canella*, M. Martini*, R. Borriello*, C. Cavicchio*, X. Muresan*, M. Benedusi*, F. Cervellati*, G. Valacchi n

MeSH headings : A549 Cells; Chloride Channels / metabolism; Electrophysiological Phenomena / drug effects; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Lung / pathology; Oxidative Stress / drug effects; Ozone / pharmacology; Patch-Clamp Techniques; Protective Agents / pharmacology; Vitamin E / pharmacology
TL;DR: The data suggest that ozone exposure is able to modify chloride current density and the use of vitamin E can prevent the above‐mentioned damage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Monoolein aqueous dispersions as a delivery system for quercetin

Biomedical Microdevices, 19(2).

By: R. Cortesi*, E. Cappellozza*, M. Drechsler*, C. Contado*, A. Baldisserotto*, P. Mariani*, F. Carducci*, A. Pecorelli, E. Esposito*, G. Valacchi*

author keywords: Quercetin; Monoolein aqueous dispersions (MAD); Monoolein; Antioxidant activity
MeSH headings : Antioxidants / chemistry; Antioxidants / toxicity; Cell Line; Drug Carriers / chemistry; Glycerides / chemistry; Humans; Kinetics; Quercetin / chemistry; Quercetin / toxicity; Water / chemistry
TL;DR: Experiments on antioxidant activity of MAD containing QT demonstrated that their activity parallel with the content of encapsulated QT within the MAD formulations produced allow us to conclude that MAD can be potentially proposed for the delivery of QT. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2017 journal article

Nanostructured lipid carriers (NLC) for the delivery of natural molecules with antimicrobial activity: production, characterisation and in vitro studies

Journal of Microencapsulation, 34(1), 63–72.

By: R. Cortesi*, G. Valacchi*, X. Muresan*, M. Drechsler*, C. Contado*, E. Esposito*, A. Grandini*, A. Guerrini*, G. Forlani*, G. Sacchetti*

author keywords: Nanoparticles; nanotechnology; formulation; nanostructured lipid carriers
MeSH headings : Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacology; Bacteria / drug effects; Bacterial Infections / drug therapy; Cell Line; Cyanobacteria / drug effects; Drug Carriers / chemistry; Fungi / drug effects; Humans; Lipids / chemistry; Mycoses / drug therapy; Nanostructures / chemistry; Nanostructures / ultrastructure
TL;DR: NLC loaded with active molecules showed a lower toxicity as compared to their free form on human cultured cells, and can be potentially proposed to control phytopathogenic organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2017 journal article

Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation

Colloids and Surfaces B: Biointerfaces, 158, 441–452.

By: