Works (209)
Updated: April 22nd, 2024 04:47
2024 journal article
A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 752.
author keywords: Rett syndrome; MECP2 mutations; Precision medicine; Proteomics; Oxidative stress
TL;DR:
By employing a multidisciplinary approach encompassing proteomics and bioinformatics analyses, as well as molecular biology assays, the study uncovered phenotypic responses linked to specific MECP2 gene mutations, contributing to a better understanding of the complexity of RTT molecular pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Sources: Web Of Science, ORCID
Added: February 12, 2024
2024 article
Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study
Ferrara, F., Yan, Xi, Pecorelli, A., Guiotto, A., Colella, S., Pasqui, A., … Valacchi, G. (2024, April 8). JOURNAL OF COSMETIC DERMATOLOGY, Vol. 4.
author keywords: 4HNE; inflammasome; inflammation; pollution; skin barrier
onlinelibrary.wiley.com (publisher PDF)
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024
2024 review
Cutaneous Redox Senescence
[Review of ]. BIOMEDICINES, 12(2).
author keywords: cutaneous senescence; reactive oxygen species; inflammation; biochemistry; molecular signaling
TL;DR:
An updated and more comprehensive approach to investigating skin senescence should include further assays of ox-inflammatory molecular pathways that can consolidate the understanding of cutaneous redox senescence.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 18, 2024
2024 journal article
Ethosomes for Curcumin and Piperine Cutaneous Delivery to Prevent Environmental-Stressor-Induced Skin Damage
ANTIOXIDANTS, 13(1).
author keywords: ethosomes (ETs); curcumin (CUR); piperin (PIP); skin; environmental stress
TL;DR:
The results highlighted that ETs can promote the skin permeation of curcumin, suggesting their possible application for the prevention of skin damage due to exogenous stressors.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 12, 2024
2024 journal article
Nutlin-3 Loaded Ethosomes and Transethosomes to Prevent UV-Associated Skin Damage
LIFE-BASEL, 14(1).
author keywords: nutlin-3; ethosomes; transethosomes; skin damage; UV radiations
TL;DR:
Ex vivo data suggest a better efficacy of transethosomes to promote nutlin-3 delivery within the skin, with respect to ethosomes, as well as in ex vivo skin explants exposed to UV radiations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: February 12, 2024
2024 journal article
Signature of paraoxonases in the altered redox homeostasis in Alzheimer's disease
CHEMICO-BIOLOGICAL INTERACTIONS, 388.
author keywords: Paraoxonase 1; Paraoxonase 2; 4-Hydroxynonenal; Oxidative stress
TL;DR:
The altered oxidative stress homeostasis in the 3xTg-AD female mice may be related to an early reduction in activity and expression of PONs enzymes most likely via a reduced brain arylesterases activity.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 12, 2024
2024 journal article
Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multi pollutant exposure
EXPERIMENTAL DERMATOLOGY, 33(1).
author keywords: 4HNE; COX2; inflammation; pollution; skin barrier
TL;DR:
This study is among the first to investigate the combined effects of three of the most harmful outdoor stressors on human skin and confirms that daily topical of an antioxidant application may prevent pollution-induced skin damage.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 29, 2024
2023 journal article
Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins
FRONTIERS IN NUTRITION, 10.
author keywords: astaxanthin; exercise; proteomics; oxylipins; inflammation; cytokines
TL;DR:
It is supported that 4-week astaxanthin versus placebo supplementation did not counter exercise-induced increases in plasma cytokines and oxylipins but was linked to normalization of post-exercise plasma levels of numerous immune-related proteins including immunoglobulins within 24 h.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: April 17, 2023
2023 journal article
Bilosomes and Biloparticles for the Delivery of Lipophilic Drugs: A Preliminary Study
ANTIOXIDANTS, 12(12).
author keywords: bile acids; nanovesicles; nanoparticles; SLN; NLC; drug solubility; nanotechnology; poorly water-soluble drugs; immunofluorescence; inflammasome
TL;DR:
Immunofluorescence experiments indicated that ursodeoxycholic acid bilosomes containing budesonide are effective in reducing the inflammatory response induced by glucose oxidase stimuli and counteract ox-inflammatory damage within intestinal cells.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 16, 2024
2023 review
Blueberry Supplementation and Skin Health
[Review of ]. ANTIOXIDANTS, 12(6).
author keywords: blueberries; skin; inflammation; polyphenol; antioxidant
TL;DR:
The argument for blueberries to possibly be an effective agent for skin health is built and the need for further research to elucidate the mechanisms behind the use of both topical application and dietary supplementation with blueberry to bolster cutaneous systems and defensive mechanisms is highlighted.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: June 14, 2023
2023 review
Bone Fracture in Rett Syndrome: Mechanisms and Prevention Strategies
[Review of ]. CHILDREN-BASEL, 10(12).
author keywords: Rett syndrome; fractures; osteoporosis; calcium; vitamin D; bisphosphonates
TL;DR:
The knowledge on risk factors for fragility fracture in patients with Rett syndrome is summarized and a possible diagnostic and therapeutic care pathway for improving low bone mineral density and reducing the risk of fragility fractures is suggested.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 8, 2024
2023 article
CADMIUM EXPOSURE AFFECTS THE PROGRESSION OF HUMAN METASTATIC MELANOMA BY INDUCING A DEREGULATION OF ANTIOXIDANT CELL RESPONSE
Casoni, A., Benedusi, M., Cervellati, F., Pecorelli, A., Ferrara, F., Vallese, A., & Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 42–43.
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 article
CONSTITUTIVE ACTIVATION OF NLRP3 INFLAMMASOME MACHINERY IN EX-VIVO MODELS OF RETT SYNDROME: FROM PATHOGENETIC ROLE TO NEW POTENTIAL THERAPEUTIC TARGET
Cordone, V., Pecorelli, A., Ferrara, F., Guiotto, A., Hayek, J., Cervellati, C., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 12–12.
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 article
Caffeic acid-loaded lipid nanoparticles as a tool to protect skin against oxidative stress: formulation and evaluation on human skin explants
Sguizzato, M., Ferrara, F., Valacchi, G., Cortesi, R., & Esposito, E. (2023, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 198, pp. S19–S19.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 journal article
Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(23).
author keywords: oxinflammation; inflammasome; pollutants; skin
TL;DR:
Among all environmental pollutants, O3, MP, and UV represented the main pollutants affecting cutaneous redox homeostasis; of note, the NLRP1 and NLRP6 inflammasomes were the main ones modulated by these outdoor stressors, suggesting their role as possible molecular targets in preventing skin disorders and the inflammaging events associated with environmental pollutants exposure.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 24, 2023
2023 article
Deregulated NLRP3 inflammasome response due to a constitutive activation of NF-kappa B p65 pro-inflammatory pathway in lymphomonocytes of Rett syndrome patients
Cordone, V., Vallese, A., Pecorelli, A., Guiotto, A., Ferrara, F., Benedusi, M., … Valacchi, G. (2023, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 198, pp. S21–S22.
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 journal article
Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach
ANTIOXIDANTS, 12(7).
author keywords: sustainability; value-added; repurposing; skin health; cosmeceuticals
TL;DR:
It is demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 17, 2023
2023 article
Editorial: Cell cycle control as a new therapeutic approach for SARS-CoV-2 infection
Rizzo, R., Caccuri, F., Valacchi, G., & Zauli, G. (2023, February 1). FRONTIERS IN PHARMACOLOGY, Vol. 14.
author keywords: cell cycle; SARS-CoV-2; p53; cytokine storm; idasanutlin
TL;DR:
The authors propose using EVs to transport small-molecule MDM2 inhibitors like Nutlin-3 and idasanutlin by enhancing p53 survival and may help modify the IFN signaling pathway and lessen the overall pro-inflammatory burden during COVID-19.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: March 13, 2023
2023 journal article
Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii)
NUTRIENTS, 15(4).
author keywords: non-mulberry silkworm pupae; angiotensin converting enzyme-inhibitory peptides; antioxidative peptides; ultrafiltration; anti-inflammatory peptides
MeSH headings : Animals; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Antioxidants / pharmacology; Protein Hydrolysates / pharmacology; Bombyx; Pupa; Endothelial Cells; Lipopolysaccharides; Peptides / pharmacology; Hypertension; Hydrolysis
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: March 20, 2023
2023 article
INFLAMMASOMES REGULATION BY ENVIRONMENTAL POLLUTANTS IN HUMAN SKIN
Ferrara, F., Pecorelli, A., Guiotto, A., Vallese, A., Cordone, V., Benedusi, M., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 38–39.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 journal article
Identification of bromelain subfamily proteases encoded in the pineapple genome
SCIENTIFIC REPORTS, 13(1).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 21, 2023
2023 journal article
Lipid-Based Nanosystems for the Topical Application of Ferulic Acid: A Comparative Study
PHARMACEUTICS, 15(7).
author keywords: ferulic acid; antioxidant molecules; transferosomes; vesicles; monoolein aqueous dispersions; topical application; cryo-TEM
TL;DR:
Results indicate that the LBNs produced with poloxamer 188 in their composition create a multilamellar system that effectively controls the release of the drug, and it is found that the type of non-ionic surfactant can impact the drug release rate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 10, 2023
2023 article
MITOCHONDRIAL DYSFUNCTION AND NLRP3 INFLAMMASOME ACTIVATION IN AUTISM SPECTRUM DISORDER
Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 20–20.
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 review
Moderate red wine intake and cardiovascular health protection: a literature review
[Review of ]. FOOD & FUNCTION, 14(14), 6346–6362.
MeSH headings : Male; Humans; Female; Wine / analysis; Cardiovascular Diseases / prevention & control; Alcoholic Beverages; Cardiovascular System; Antioxidants; Ethanol; Alcohol Drinking
TL;DR:
Red wine contains both alcoholic and non-alcoholic ingredients; however, it is yet unclear which is to blame for these effects, so new studies should focus more on the characterization of the individual components of wine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 24, 2023
2023 journal article
Modulation of Cutaneous Carotenoid Content via Ozone Exposure
COSMETICS, 10(4).
author keywords: skin barrier; carotenoids; ozone exposure; Raman spectroscopy; statistics
TL;DR:
Evaluating the variations in carotenoid content present in human skin prior to and after O3 exposure in 141 human subjects confirmed their importance in the maintenance of cutaneous redox homeostasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: September 11, 2023
2023 journal article
Ox-inflammasome involvement in neuroinflammation
FREE RADICAL BIOLOGY AND MEDICINE, 207, 161–177.
TL;DR:
The current knowledge on the involvement of inflammasome in the main neuropathologies is provided, emphasizing the importance to further clarify the role of oxidative stress in its activation including therole of mitochondria in inflammaome-induced neuroinflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: September 5, 2023
2023 article
OxInflammation in Alzheimer's disease
Cervellati, C., Zuliani, G., & Valacchi, G. (2023, December). NEURAL REGENERATION RESEARCH, Vol. 18, pp. 2709–2710.
TL;DR:
Or pro-inflammatory cytokines, such as reactive microglia, dysfunctional mitochondria, amyloid-β aggregates, are involved in inflammation and cell reprograming.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 23, 2023
2023 article
Protective role of Ibuprofen-Curcumin co-load nanomicelles against oxidative stress and inflammasome activation mediated by indoor pollution exposure in A549 cells
Garces, M., Pecorelli, A., Moretton, M., Magnani, N., Chiapetta, D., Alvarez, S., … Valacchi, G. (2023, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 208, pp. S151–S152.
Sources: Web Of Science, ORCID
Added: January 2, 2024
2023 article
ROLE OF COENZYME Q10 IN MITOCHONDRIAL DYSFUNCTION AND OXIDATIVE DAMAGE IN RETT SYNDROME
Silvestri, S., Marcheggiani, F., Orlando, P., Cirilli, I., Mengarelli, F., Vallese, A., … Tiano, L. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 16–16.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 article
THE POSSIBLE MODULATION OF NRF2 AND NF-KB CROSSTALK BY SULFORAPHANE IN THE PROGRESSION OF HUMAN MELANOMA
Benedusi, M., Canella, R., Vallese, A., Casoni, A., Guerra, M., Rispoli, G., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 57–57.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 article
THE PROTECTIVE ROLE OF ENDOTHELIAL alpha 1AMPK IN AIRCRAFT NOISE-INDUCED VASCULAR DYSFUNCTION AND OXIDATIVE STRESS IS MEDIATED BY FASTING, EXERCISE AND PHARMACOLOGICAL TREATMENT
Cordone, V., Pecorelli, A., Ferrara, F., Guiotto, A., Hayek, J., Cervellati, C., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 11–12.
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 journal article
Tension as a key factor in skin responses to pollution
SCIENTIFIC REPORTS, 13(1).
TL;DR:
The present work demonstrates that cutaneous exposure to ozone induces AMPs gene and protein levels and that the presence of tension can further modulate their expression, confirming the ability of pollution to induce the cutaneous expression of AMPs via redox signaling and corroborates the principle that skin explants are a good and reliable model to study skin responses.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 22, 2024
2023 article
The pathogenic axis between mitochondrial dysfunction and NLRP3 inflammasome activation in Autism Spectrum Disorder
Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 208, pp. S49–S49.
Sources: Web Of Science, ORCID
Added: November 24, 2023
2022 article
Aberrant Mitochondrial Bioenergetics Fuels Inflammasome Machinery in Autism Spectrum Disorder
Pecorelli, A., Francesca, F., Cordone, V., Guiotto, A., Cervellati, C., Hayek, J., & Valacchi, G. (2022, February 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 180, pp. 97–98.
Sources: Web Of Science, ORCID
Added: April 25, 2022
2022 journal article
Biological activity of new bioactive steroids deriving from biotransformation of cortisone
MICROBIAL CELL FACTORIES, 21(1).
author keywords: Biotransformations; Cortisone; Steroids; Neuroprotective; Anti-inflammatory; Antioxidant
MeSH headings : Cortisone; Antioxidants / pharmacology; Biotransformation; Steroids; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use
TL;DR:
A preliminary in vitro study aimed at evaluating the mutagenic, anti-inflammatory, antioxidant and neuroprotective activity of SCA and SCB molecules obtained from the biotransformation of cortisone using Rh.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID
Added: December 5, 2022
2022 journal article
Chemoresistive Sensors for Cellular Type Discrimination Based on Their Exhalations
NANOMATERIALS, 12(7).
author keywords: chemoresistivity; nanostructures; sensors; cells; tumor; VOCs
TL;DR:
The encouraging results presented here, although preliminary, foresee the development of sensor arrays capable of identifying tumor presence and its type.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 25, 2022
2022 journal article
Dimethyl Fumarate-Loaded Transethosomes: A Formulative Study and Preliminary Ex Vivo and In Vivo Evaluation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(15).
author keywords: dimethyl fumarate; cryogenic transmission electron microscopy; wound healing; transethosomes; transdermal delivery
MeSH headings : Administration, Cutaneous; Dimethyl Fumarate / pharmacology; Drug Delivery Systems / methods; Humans; Liposomes / chemistry; Phosphatidylcholines / metabolism; Skin / metabolism; Skin Absorption
TL;DR:
The selected transethosome gel, loading 25 mg/mL dimethyl fumarate, was not irritant after cutaneous application under occlusion, suggesting its possible suitability in the treatment of wounds caused by diabetes mellitus or peripheral vascular diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 29, 2022
2022 article
Editorial: Angiogenesis and Nutraceuticals
Trabalzini, L., Tundis, R., Valacchi, G., Evelson, P. A., & Finetti, F. (2022, May 30). FRONTIERS IN PHARMACOLOGY, Vol. 13.
author keywords: angiogenesis; nutraceuticals; endothelial cells; foods; food-derived products
TL;DR:
Identification of natural food components for preventing or ameliorating angiogenesis-associated complications would be of a greater advantage because of their low toxicity or limited side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 20, 2022
2022 journal article
Ethosomes and Transethosomes as Cutaneous Delivery Systems for Quercetin: A Preliminary Study on Melanoma Cells
PHARMACEUTICS, 14(5).
author keywords: quercetin; ethosome; transethosome; in vitro release test; in vitro permeation test; Franz cell; wound healing; migration assay
TL;DR:
To overcome quercetin low bioavailability, scarce solubility and poor permeability that hamper its pharmaceutical use, the drug was loaded in ethosomes and transethosomes based on different concentrations of phosphatidylcholine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 13, 2022
2022 journal article
Extra Virgin Olive Oil Extracts of Indigenous Southern Tuscany Cultivar Act as Anti-Inflammatory and Vasorelaxant Nutraceuticals
ANTIOXIDANTS, 11(3).
author keywords: olive oil; traceability quality; food origin; luteolin; oleuropein; CaCo-2 cells; Nrf2; NF-kappa B
TL;DR:
The nutraceutical properties of autochthonous Tuscany EVOO cv showed promising anti-inflammatory and vasorelaxant effects, both in the presence and absence of an intact endothelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 18, 2022
2022 article
Inflammasome involvement in CS-induced damage in HaCaT keratinocytes
Prieux, R., Ferrara, F., Cervellati, F., Guiotto, A., Benedusi, M., & Valacchi, G. (2022, April 15). IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, Vol. 4.
MeSH headings : Animals; Cytokines / metabolism; Inflammasomes / metabolism; Interleukin-1beta / metabolism; Keratinocytes / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Skin / metabolism
TL;DR:
The importance of the inflammasome machinery in CS that more in general, in pollution, affects cutaneous tissues and the important cross-talk between different members of the NLRP inflammaome family is highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: May 2, 2022
2022 article
Involvement Of Ferroptosis In Rett Syndrome
Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Cervellati, C., Hayek, J., … Pecorelli, A. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.
Sources: Web Of Science, ORCID
Added: March 6, 2023
2022 article
Loss of Scavenger Receptor B1 (SR-B1) in Brain of a Rett Syndrome Mouse Model
Pecorelli, A., Ferrara, F., Guiotto, A., Vallese, A., Cordone, V., Belmonte, G., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.
Sources: Web Of Science, ORCID
Added: March 6, 2023
2022 journal article
MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation
JOURNAL OF PERSONALIZED MEDICINE, 12(2).
author keywords: microRNAs; environmental risk factors; cutaneous tissues; ozone exposure
TL;DR:
Investigation in human skin biopsies exposed to diesel fumes, ozone, and UV light for over 24 h of exposure found UV and ozone-induced microRNA alteration right after exposure, while the peak of their deregulations induced by diesel fumes was reached only at the end of the 24 h.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 4, 2022
2022 article
Mutations Specific Redox Regulation Pathway In Rett Syndrome By The Use Of Transcriptomics And Proteomics Approaches
Pasqui, A., Cicaloni, V., Tinti, L., Mori, A., Bruttini, M., Pecorelli, A., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.
Sources: Web Of Science, ORCID
Added: March 6, 2023
2022 review
Oxidative-Stress-Sensitive microRNAs in UV-Promoted Development of Melanoma
[Review of ]. CANCERS, 14(13).
author keywords: skin cancer; sunlight; redox imbalance; miRNome; mutations; epigenome
TL;DR:
Current evidence suggests a complex interaction between UV-promoted deregulation of redox-sensitive miRNAs and known signal-transduction pathways underlying malignant transformation of melanocytes to melanoma, which could have relevant implications for future therapeutic approaches aimed at counteracting UV-induced redox and miRNome imbalances.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 26, 2022
2022 journal article
The constitutive activation of TLR4-IRAK1-NF kappa B axis is involved in the early NLRP3 inflammasome response in peripheral blood mononuclear cells of Rett syndrome patients
FREE RADICAL BIOLOGY AND MEDICINE, 181, 1–13.
author keywords: MeCP2; p65; Oxinflammation; Interleukin-18; Interleukin-1 beta
MeSH headings : Humans; Inflammasomes / genetics; Inflammasomes / metabolism; Interleukin-1 Receptor-Associated Kinases / genetics; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Leukocytes, Mononuclear / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Rett Syndrome / genetics; Rett Syndrome / metabolism; Toll-Like Receptor 4 / genetics
TL;DR:
The deregulation of inflammasome components was even found in THP-1 cells silenced for MECP2 and importantly, in plasma compartment of RTT subjects, from the earliest stages of the pathology or in correlation with the severity of MeCP2 mutations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: March 14, 2022
2022 journal article
Ubiquitination as a key regulatory mechanism for O-3-induced cutaneous redox inflammasome activation
REDOX BIOLOGY, 56.
Contributors: F. Ferrara*, V. Cordone *, A. Pecorelli* , M. Benedusi *, E. Pambianchi*, A. Guiotto*, A. Vallese* , F. Cervellati *, *
author keywords: Inflammasomes; OxInflammation; Proteasome; UBR2; N-end rule pathway
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Air Pollutants; Apoptosis Regulatory Proteins / genetics; Catalase / metabolism; Cytokines / metabolism; Environmental Pollutants; Humans; Hydrogen Peroxide / metabolism; Inflammasomes / metabolism; NLR Proteins / metabolism; Oxidation-Reduction; Ozone / metabolism; Particulate Matter; Reactive Oxygen Species / metabolism; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
TL;DR:
It is reported for the first time that O3, one of the most toxic pollutants, activates the NLRP1 inflammasome in human keratinocytes via oxidative stress mediators as hydrogen peroxide (H2O2) and 4-hydroxy-nonenal (4HNE).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: September 12, 2022
2022 article
Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox Inflammasome activation
Ferrara, F., Cordone, V., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.
Sources: Web Of Science, ORCID
Added: March 6, 2023
2022 review
Ultraviolet Light Protection: Is It Really Enough?
[Review of ]. ANTIOXIDANTS, 11(8).
author keywords: skin aging; ultraviolet light; solar radiation; pollution; reactive oxygen species; oxidative stress; antioxidants; chelators
TL;DR:
An updated, more comprehensive approach to environmental or atmospheric aging protection should include sun protective measures, broad spectrum sunscreens, antioxidants, chelating agents, and DNA repair enzymes.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: September 6, 2022
2021 journal article
"Plurethosome" as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation
PHARMACEUTICS, 13(8).
author keywords: phosphatidylcholine; poloxamer; mangiferin; in vitro diffusion; antioxidant
TL;DR:
The antioxidant and anti-inflammatory potential effect of mangiferin against pollutants was evaluated on 3D human skin models exposed to O3 and the protective effect exerted by plurethosomes and transethosomes suggests their possible application to enhance the cutaneous antioxidant defense status.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: September 7, 2021
2021 journal article
Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage
COSMETICS, 8(4).
author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
TL;DR:
It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: December 2, 2021
2021 article
Alteration of cellular defensive response and a possible involvement of ferroptosis cell death in Rett syndrome disorder
Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Hayek, J., Cervellati, C., … Pecorelli, A. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: April 5, 2021
2021 journal article
Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure
FREE RADICAL BIOLOGY AND MEDICINE, 166, 324–336.
author keywords: Nanoparticles; Lung epithelium; Nanotoxicology; Oxidative metabolism; NADPH oxidase; Mitochondria
MeSH headings : Animals; Hydrogen Peroxide; Lung; Metal Nanoparticles / toxicity; Mice; Oxygen; Silver
TL;DR:
Results show that AgNP exposure alters O2 metabolism leading to a redox imbalance, which may be responsible for the impaired lung function observed due to alveolar epithelial injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 19, 2021
2021 review
Altered Bone Status in Rett Syndrome
[Review of ]. LIFE-BASEL, 11(6).
author keywords: MeCP2; bone mineral density; bone metabolism; osteoblast; WNT pathway
TL;DR:
Evidence from human and animal studies supports the idea that MECP2 mutation could be associated with altered epigenetic regulation of bone-related factors and signaling pathways, including SFRP4/WNT/β-catenin axis and RANKL/RANK/OPG system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 12, 2021
2021 article
BACE1 role in Alzheimer's disease and other dementias: from the theory to the practice
Cervellati, C., Valacchi, G., & Zuliani, G. (2021, December). NEURAL REGENERATION RESEARCH, Vol. 16, pp. 2407–2408.
TL;DR:
Alzheimer's disease is a multifactorial and multifaceted disease, with a complex and still not completely understood pathogenesis, and it is now amply recognized that a combination of multiple biochemical, immune system and vascular abnormalities must also occur to define the direction of disease trajectory.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 10, 2021
2021 review
Bench approaches to study the detrimental cutaneous impact of tropospheric ozone
[Review of ]. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 31(1), 137–148.
author keywords: Environmental pollution; Skin; 3D skin tissue model; Oxidative stress; Skin protection
MeSH headings : Air Pollutants / adverse effects; Air Pollutants / analysis; Cities; Humans; Lipid Peroxidation; Oxidative Stress; Ozone / adverse effects; Ozone / analysis; Skin / metabolism
TL;DR:
Having a better understanding of O 3 effects on skin barrier properties and stress responses could help the whole dermato-cosmetic industry to design innovative protective solutions and develop specific cosmetic regime to protect the skin of every citizen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 24, 2020
2021 journal article
Circadian Deregulation as Possible New Player in Pollution-Induced Tissue Damage
ATMOSPHERE, 12(1).
author keywords: circadian clock; pollution; antioxidant system
TL;DR:
It is hypothesized that chronodistruption can exacerbate cell vulnerability to exogenous damaging agents, and a possible common mechanism of action in deregulation of the homeostasis of the pulmonary, cardiovascular and cutaneous tissues and in its involvement in the development of pathological conditions is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: February 15, 2021
2021 review
Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer's Disease: A Narrative Review
[Review of ]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021.
MeSH headings : Alzheimer Disease / etiology; Alzheimer Disease / metabolism; Alzheimer Disease / pathology; Animals; Anti-Inflammatory Agents / metabolism; Antioxidants / metabolism; Humans; Inflammation / complications; Lipoproteins, HDL / metabolism; Oxidative Stress
TL;DR:
This review summarized and critically analyzed the most significant findings linking HDL accessory proteins and AD and discusses the most convincing hypothesis explaining the mechanism by which an observed systemic occurrence may have repercussions in the brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: February 22, 2021
2021 journal article
Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 5(171).
MeSH headings : Cell Differentiation; Cells, Cultured; Coculture Techniques; Epidermal Cells; Epidermis; Filaggrin Proteins; Humans; Keratinocytes; Skin
TL;DR:
This protocol represents a straightforward and reproducible in vitro method to cultivate reconstructed human epidermis as a tool to assess environmental effects and a broad range of skin-related studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID
Added: June 21, 2021
2021 journal article
Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure
ANTIOXIDANTS, 10(12).
author keywords: cosmeceuticals; pollution; iron-chelator
TL;DR:
It is suggested that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 24, 2022
2021 article
Deregulated inflammasome response in Rett syndrome
Cordone, V., Pecorelli, A., Falone, S., Hayek, J., Amicarelli, F., & Valacchi, G. (2021, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 177.
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, ORCID
Added: February 21, 2022
2021 journal article
Ethosomes and Transethosomes for Mangiferin Transdermal Delivery
ANTIOXIDANTS, 10(5).
author keywords: ethosomes; transethosomes; mangiferin; franz cell; antioxidants
TL;DR:
The effectiveness of mangiferin loaded in nanosystems to protect cells from damage was demonstrated, evaluating, in vitro, the antioxidant and anti-inflammatory effect of ethosomes and transethosomes on human keratinocytes exposed to cigarette smoke as an oxidative and inflammatory challenger.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 10, 2021
2021 journal article
Formulative Study and Intracellular Fate Evaluation of Ethosomes and Transethosomes for Vitamin D3 Delivery
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(10).
author keywords: cell culture; cholecalciferol; cryogenic transmission electron microscopy; in vitro test; light microscopy; lipid nanocarriers; transmission electron microscopy
MeSH headings : Cell Line; Chemistry, Pharmaceutical / methods; Cholecalciferol / administration & dosage; Cholecalciferol / metabolism; Cholecalciferol / pharmacology; Drug Carriers / chemistry; Drug Delivery Systems / methods; Fibroblasts / drug effects; Humans; Keratinocytes / drug effects; Lipids / chemistry; Liposomes / chemistry; Myoblasts / drug effects; Nanocapsules / chemistry; Pilot Projects; Skin / metabolism; Skin Absorption; Surface-Active Agents / metabolism
TL;DR:
Both ethosomes and transethosomes proven to have physicochemical properties optimal for transdermal penetration and efficient vitamin D3 loading; moreover, nanocarriers were easily internalized by all cell types, although they followed distinct intracellular fates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: June 28, 2021
2021 journal article
Impaired mitochondrial quality control in Rett Syndrome
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 700.
author keywords: RTT Syndrome; Oxidative stress; Mitochondrial quality control; Mitophagy; Apoptosis
MeSH headings : Adolescent; Adult; Apoptosis; Caspase 3 / genetics; Caspase 3 / metabolism; Caspase 7 / genetics; Caspase 7 / metabolism; Child; Dynamins / genetics; Dynamins / metabolism; Female; Fibroblasts / metabolism; Fibroblasts / pathology; GTP Phosphohydrolases / genetics; GTP Phosphohydrolases / metabolism; Humans; Membrane Proteins / genetics; Membrane Proteins / metabolism; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mitochondria / genetics; Mitochondria / metabolism; Mitochondria / pathology; Mitochondrial Membrane Transport Proteins / genetics; Mitochondrial Membrane Transport Proteins / metabolism; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Mitophagy; Oxidation-Reduction; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology
TL;DR:
It is shown that RTT fibroblasts have networks of hyperfused mitochondria with morphological abnormalities and increased mitochondrial volume, shedding light on new aspects of mitochondrial dysfunction in RTT that are represented by defective mitochondrial QC pathways, providing new potential targets for a therapeutic intervention aimed at slowing down clinical course and manifestations in the affected patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: March 15, 2021
2021 article
Improper enzymatic defensive responses in Rett syndrome disorder
Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Hayek, J., Cervellati, C., … Pecorelli, A. (2021, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 177.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: February 21, 2022
2021 journal article
Inflammasome Activation in Pollution-Induced Skin Conditions
PLASTIC AND RECONSTRUCTIVE SURGERY, 147(1S-2), 15S–24S.
MeSH headings : Air Pollutants / adverse effects; Air Pollution / adverse effects; Animals; Dermatitis / immunology; Dermatitis / pathology; Dermatitis / prevention & control; Disease Models, Animal; Environmental Exposure / adverse effects; Furans; Heterocyclic Compounds, 4 or More Rings / pharmacology; Heterocyclic Compounds, 4 or More Rings / therapeutic use; Humans; Indenes; Inflammasomes / antagonists & inhibitors; Inflammasomes / immunology; Inflammasomes / metabolism; Interleukin-18 / metabolism; Interleukin-1beta / metabolism; Mice; NLR Family, Pyrin Domain-Containing 3 Protein / antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Nitriles / pharmacology; Nitriles / therapeutic use; Skin / drug effects; Skin / immunology; Skin / pathology; Skin Aging / immunology; Sulfonamides; Sulfones / pharmacology; Sulfones / therapeutic use
TL;DR:
The cutaneous inflammasome is proposed as a novel target of pollutant exposure and the eventual usage of inflamMASome inhibitor as new technologies to counteract pollution-induced skin damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 6, 2021
2021 article
Mitochondrial dynamics and quality control pathways impairment in Rett Syndrome and Autism Spectrum Disorder
Pecorelli, A., Guiotto, A., Cordone, V., Cervellati, F., Benedusi, M., Cervellati, C., … Valacchi, G. (2021, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 177, pp. S17–S18.
Sources: Web Of Science, ORCID
Added: February 28, 2022
2021 article
Mitochondrial dysfunction fuels inflammasome machinery in Autism Spectrum Disorder
Pecorelli, A., Cordone, V., Guiotto, A., Cervellati, F., Benedusi, M., Cervellati, C., … Valacchi, G. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.
Sources: Web Of Science, ORCID
Added: April 5, 2021
2021 article
NALP1 involvement in cigarette smoke induces cutaneous inflammation
Prieux, R., Benedusi, M., Ferrara, F., Guiotto, A., Cervellati, F., & Valacchi, G. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.
Sources: Web Of Science, ORCID
Added: April 5, 2021
2021 journal article
Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
MOLECULES, 26(13).
author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
TL;DR:
The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: June 23, 2021
2021 journal article
Oxidative metabolism in the cardiorespiratory system after an acute exposure to nickel-doped nanoparticles in mice
TOXICOLOGY, 464.
author keywords: nanoparticles; nickel; reactive oxygen species; oxidative stress; NADPH oxidase
MeSH headings : Animals; Antioxidants / metabolism; Female; Lung / drug effects; Lung / metabolism; Male; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Mice; Mitochondria / drug effects; Nickel / chemistry; Oxidation-Reduction / drug effects; Oxidative Stress / drug effects; Oxygen Consumption / drug effects; Silicon Dioxide / chemistry
TL;DR:
The results showed that the O2 metabolism analysis is a critical area of study following Ni-NP inhalation, and provides novel data linking the redox metabolisms alterations elicited by exposure to Ni (II) adsorbed to NP and cardiorespiratory toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 29, 2021
2021 article
Proteome composition and profiling of bioactive peptides of edible Antheraea assamensis pupae by sequential enzymatic digestion and kinetic modeling of in vitro gastrointestinal digestion
Sarkar, P., Valacchi, G., & Duary, R. K. (2021, October 28). EUROPEAN FOOD RESEARCH AND TECHNOLOGY, Vol. 10.
author keywords: Insect hydrolysate; Papain; Thermolysin; Gastrointestinal digestion; Free amino acids; Enzyme kinetics
TL;DR:
The indigenous Muga (Antheraea assamensis) pupae proteome is profile and the suitable parameters to procure ACE inhibitory, DPP-IV inhibitory and antioxidative peptide mix with suitable enzymatic interventions are evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 8, 2021
2021 review
SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?
[Review of ]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1486(1), 15–38.
author keywords: air pollution; coronavirus; particulate matter; ozone; nitrogen dioxide; viral infection
MeSH headings : Adaptive Immunity; Air Pollutants / adverse effects; Air Pollution / adverse effects; COVID-19 / etiology; COVID-19 / immunology; COVID-19 / virology; Host Microbial Interactions; Humans; Immunity, Innate; Models, Biological; Pandemics; Particulate Matter / adverse effects; Receptors, Virus / physiology; Respiratory System / physiopathology; SARS-CoV-2 / immunology; SARS-CoV-2 / pathogenicity; SARS-CoV-2 / physiology; Toll-Like Receptors / physiology; Virus Internalization; Virus Replication
TL;DR:
Air pollution exposure may affect different stages of the viral life cycle, including inhibition of mucociliary clearance, alteration of viral receptors and proteases required for entry, changes to antiviral interferon production and viral replication, changes in viral assembly mediated by autophagy, prevention of uptake by macrophages, and promotion of viral spread by increasing epithelial permeability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 19, 2020
2021 journal article
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents
ACS CHEMICAL NEUROSCIENCE, 12(9), 1716–1736.
author keywords: Endocannabinoid system; fatty acid amide hydrolase; enzyme inhibitors; selective inhibitors; epilepsy; temporal lobe epilepsy; seizures
MeSH headings : Amidohydrolases; Anticonvulsants / pharmacology; Endocannabinoids; Enzyme Inhibitors / pharmacology; Humans; Seizures
TL;DR:
The discovery of selective anandamide catabolic enzyme fatty acid amide hydrolase (FAAH) inhibitors with promising antiepileptic efficacy are reported, starting from a further investigation of the authors' prototypical inhibitor 2a.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: June 10, 2021
2021 article
The role of pulmonary ORCC and CLC-2 channels in the response to oxidative stress
Canella, R., Benedusi, M., Martini, M., Guiotto, A., Cervellati, F., & Valacchi, G. (2021, May 7). MOLECULAR & CELLULAR TOXICOLOGY, Vol. 5.
author keywords: Human lung epithelial cells; Chloride channels; Ozone; Oxidative stress; Patch clamp technique
TL;DR:
It is suggested that O3 activates ORCC channels and slightly inhibited ClC-2 channels in the negative voltage range and opens the possibility of identifying the biomolecular changes induced by O3 allowing a possible pharmacological intervention towards chloride current due to oxidative stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 10, 2021
2021 article
Ubiquitination as a key regulatory mechanism for O-3-induced cutaneous redox inflammasome activation
Ferrara, F., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., Cervellati, F., & Valacchi, G. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.
Sources: Web Of Science, ORCID
Added: April 5, 2021
2020 journal article
A proteomics approach to further highlight the altered inflammatory condition in Rett syndrome
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 696.
author keywords: Rare disease; Rett syndrome; Inflammatory status; NLRP3 inflammasome; Mass spectrometry-based proteomics
MeSH headings : Adult; Female; Fibroblasts / chemistry; Humans; Inflammation / complications; Inflammation / metabolism; Protein Interaction Maps; Proteome / analysis; Proteome / metabolism; Proteomics; Rett Syndrome / complications; Rett Syndrome / metabolism; Young Adult
TL;DR:
Results provide a detailed insight into the molecular pathways involved in RTT immune dysfunction that, causing tissue and organ damage, can increase the vulnerability of affected patients to unknown endogenous factors or infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 19, 2021
2020 journal article
Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder
FASEB JOURNAL, 34(5), 6521–6538.
author keywords: 4-hydroxynonenal; fission; fusion; mitophagy; nuclear factor erythroid 2-related factor 2
MeSH headings : Adolescent; Adult; Autism Spectrum Disorder / metabolism; Autism Spectrum Disorder / pathology; Case-Control Studies; Child; Energy Metabolism; Female; Fibroblasts / metabolism; Fibroblasts / pathology; Humans; Male; Mitochondria / metabolism; Mitochondria / pathology; Mitochondrial Dynamics; Mitochondrial Proteins / metabolism; Oxidative Stress; Young Adult
TL;DR:
It is suggested that many of the changes observed in mitochondria could represent compensatory mechanisms by which ASD cells try to adapt to altered energy demand, possibly resulting from a chronic oxinflammatory status.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 20, 2020
2020 journal article
Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation
REDOX BIOLOGY, 28.
author keywords: NLRP3; ASC; Inflammatory status; Cytokines; MeCP2
MeSH headings : Biomarkers; Cytokines / metabolism; Disease Susceptibility; Fibroblasts / metabolism; Fluorescent Antibody Technique; Humans; Inflammasomes / metabolism; Inflammation Mediators / metabolism; Interleukin-1beta / metabolism; NF-kappa B / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Protein Transport; Rett Syndrome / etiology; Rett Syndrome / metabolism
TL;DR:
It is suggested that RTT patients exhibited a challenged inflammasome machinery at cellular and systemic level, which may contribute to the subclinical inflammatory state feedback observed in this pathology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 30, 2019
2020 journal article
Circadian Clock and OxInflammation: Functional Crosstalk in Cutaneous Homeostasis
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020.
MeSH headings : Cells, Cultured; Circadian Clocks / physiology; Homeostasis; Humans; Inflammation / metabolism; Inflammation / pathology; Keratinocytes / cytology; Keratinocytes / metabolism; Skin / metabolism; Skin / pathology
TL;DR:
The results suggest that a synchronized circadian clock not only facilitates the protective role of NRF2 in terms of a faster and more efficient defensive response against environmental insults but also moderates the cellular damage resulting from a condition of chronic inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: May 26, 2020
2020 journal article
Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1866(7).
author keywords: Rett syndrome; Skin primary fibroblasts; Proteasome; alpha-Ring; PAC1; PAC2
MeSH headings : Codon, Nonsense / genetics; Dual Specificity Phosphatase 2 / genetics; Fibroblasts / metabolism; Gene Expression Regulation; Genetic Diseases, X-Linked / genetics; Genetic Diseases, X-Linked / pathology; Humans; Methyl-CpG-Binding Protein 2 / genetics; Neurodevelopmental Disorders / genetics; Neurodevelopmental Disorders / pathology; Primary Cell Culture; Proteasome Endopeptidase Complex / genetics; Proteolysis; Rett Syndrome / genetics; Rett Syndrome / pathology; Skin / metabolism; Skin / pathology; Ubiquitin / genetics
TL;DR:
Molecular, transcription and proteomic analyses indicate that MeCP2 mutations down-regulate the expression of one proteasome subunit, α7, and of two chaperones, PAC1 and PAC2, which bind each other in the earliest step of proteAsome biogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 15, 2020
2020 journal article
Ethosomes for Coenzyme Q10 Cutaneous Administration: From Design to 3D Skin Tissue Evaluation
ANTIOXIDANTS, 9(6).
author keywords: ethosome; ubiquinone; H2O2; penetration enhancers; dermal administration; reconstituted human epidermis; small angle X-ray scattering
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 10, 2020
2020 journal article
Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study
COLLOIDS AND SURFACES B-BIOINTERFACES, 185.
author keywords: Biocompatible polymers; Polymer gels; In vitro diffusion; Polymer membranes; Gallic acid; Franz cell
MeSH headings : Adjuvants, Immunologic / pharmacology; Adjuvants, Immunologic / therapeutic use; Cell Line; Cell Movement / drug effects; Diffusion; Elasticity; Gallic Acid / pharmacology; Gallic Acid / therapeutic use; Gels / chemistry; Humans; Kinetics; Melanoma / drug therapy; Phase Transition; Poloxamer / chemistry; Rheology; Temperature; Viscosity; Wound Healing / drug effects
TL;DR:
Scratch wound healing and migration assays conducted on human keratinocytes and melanoma cells demonstrated the ability of gallic acid loaded gel to inhibit cellular migration, suggesting its potential as adjuvant strategy for melanoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 13, 2020
2020 review
Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies
[Review of ]. PARTICLE AND FIBRE TOXICOLOGY, 17(1).
author keywords: Particulate matter; Air pollution; Urban pollution; Skin models; Skin; In vitro studies; In vivo studies; Oxidative stress; Inflammation; Barrier dysfunction
MeSH headings : Air Pollutants / toxicity; Air Pollution; Humans; Oxidative Stress; Particulate Matter / toxicity; Reactive Oxygen Species; Skin / drug effects
TL;DR:
Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 24, 2020
2020 journal article
Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / blood; Alzheimer Disease / diagnosis; Amyloid Precursor Protein Secretases / blood; Aspartic Acid Endopeptidases / blood; Dementia, Vascular / blood; Dementia, Vascular / diagnosis; Female; Humans; Male
TL;DR:
It is shown for the first time that the increase in peripheral BACE1 activity is a common feature of LOAD and VAD, thus underlying a further pathogenic link between these two forms of dementia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 journal article
Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery
ANTIOXIDANTS & REDOX SIGNALING, 33(3), 191–210.
author keywords: Alzheimer's disease; inflammation; multiple sclerosis; vascular dementia
MeSH headings : Animals; Biomarkers; Blood-Brain Barrier / metabolism; Brain / metabolism; Brain / pathology; Disease Susceptibility; Dysbiosis; Humans; Inflammation / etiology; Inflammation / metabolism; Inflammation / pathology; Nervous System Diseases / etiology; Nervous System Diseases / metabolism; Nervous System Diseases / pathology; Oxidative Stress; Peripheral Nerves / metabolism; Peripheral Nerves / pathology
TL;DR:
Reaching a definitive clinical/epidemiological appreciation of the etiopathogenic significance of the connection between peripheral and brain inflammation in neurologic disorders is pivotal since it could open novel therapeutic avenues for these diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 27, 2020
2020 journal article
KRIT1 as a possible new player in melanoma aggressiveness
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 691.
author keywords: KRIT1; Melanoma; Tumor suppressor; N-cadherin; Inflammation; beta-catenin
MeSH headings : Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Cell Movement / physiology; Cell Nucleus / metabolism; Cell Proliferation / genetics; Down-Regulation; Female; Gene Knockdown Techniques / methods; Humans; KRIT1 Protein / genetics; KRIT1 Protein / metabolism; Male; Melanocytes / metabolism; Melanoma / metabolism; Melanoma / pathology; Middle Aged; beta Catenin / metabolism
TL;DR:
KRIT1 has been studied as a regulator of endothelial cell functions and represents a determinant in the pathogenesis of Cerebral Cavernous Malformation, a cerebrovascular disease characterized by the formation of clusters of abnormally dilated and leaky blood capillaries, which predispose to seizures, neurological deficits and intracerebral hemorrhage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 5, 2020
2020 journal article
Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 690.
author keywords: Alkaptonuria; Osteoblast; Oxidative stress; Nrf2; Mitochondria; NADPH oxidase
MeSH headings : Alkaptonuria / metabolism; Cell Line; DNA-Binding Proteins / metabolism; Homeostasis / physiology; Homogentisic Acid / metabolism; Humans; Hydrogen Peroxide / metabolism; Mitochondria / metabolism; Mitochondria / ultrastructure; NADPH Oxidases / metabolism; NF-E2-Related Factor 2 / metabolism; Osteoblasts / cytology; Oxidation-Reduction; Oxidative Stress / physiology; Signal Transduction; Superoxide Dismutase / metabolism; Thioredoxins / metabolism
TL;DR:
HGA is able to alter the cellular redox homeostasis by modulating the endogenous ROS production via NOX activation and mitochondrial dysfunctions and impair the cellular response mechanism, which can be useful for understanding the pathophysiology of AKU.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 19, 2021
2020 review
Mimicking cigarette smoke exposure to assess cutaneous toxicity
[Review of ]. TOXICOLOGY IN VITRO, 62.
author keywords: Cigarette smoke; Skin models; Inflammation; Oxidative stress; Psoriasis; Atopic dermatitis
MeSH headings : Animals; Humans; Skin / drug effects; Skin Diseases / chemically induced; Tobacco Products; Tobacco Smoke Pollution / adverse effects
TL;DR:
An update is provided on the skin models currently available to study cigarette smoke exposure and the known pathways involved in cutaneous toxicity and the inflammatory skin pathologies potentially induced and/or exacerbated by cigarette smoke Exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 30, 2019
2020 journal article
Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 30(2), 112–119.
author keywords: inflammation exercise; oxidative stress; peripheral blood mononuclear cells
TL;DR:
Flavonoid supplementation prior to intensive exercise decreased plasma peroxidation and oxidative damage, as determined by 4-hydroxynonenal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 6, 2020
2020 journal article
NADPH oxidase and mitochondria are relevant sources of superoxide anion in the oxinflammatory response of macrophages exposed to airborne particulate matter
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 205.
author keywords: Air pollution; Oxidative stress; Inflammation; Mitochondria; NADPH oxidase; Macrophages
MeSH headings : Air Pollutants / toxicity; Animals; Antioxidants / metabolism; Coal Ash / toxicity; Hydrogen Peroxide / metabolism; Inflammation; Macrophages, Alveolar / drug effects; Macrophages, Alveolar / immunology; Macrophages, Alveolar / metabolism; Mice; Mitochondria / drug effects; Mitochondria / immunology; Mitochondria / metabolism; NADPH Oxidases / metabolism; Oxidation-Reduction; Oxidative Stress / drug effects; Oxidative Stress / immunology; Particulate Matter / toxicity; RAW 264.7 Cells; Superoxides / metabolism; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
The results indicate that PM exposure induces direct activation of macrophages, leading to inflammation and increased reactive oxygen species production through NOX and mitochondria, which impairs antioxidant defense and may cause mitochondrial dysfunction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 16, 2020
2020 journal article
Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid
NANOMATERIALS, 10(5).
author keywords: solid lipid nanoparticles; caffeic acid; poloxamer; small angle X-ray scattering; cigarette smoke
TL;DR:
The antioxidant effect of caffeic acid loaded in nanoparticulate gel has been demonstrated by ex-vivo evaluation on human skin explants exposed to cigarette smoke, suggesting a protective role exerted by the nanoparticles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 13, 2020
2020 journal article
Particulate Matter Induces Tissue OxInflammation: From Mechanism to Damage
ANTIOXIDANTS & REDOX SIGNALING, 33(4), 308–326.
author keywords: oxidative stress; inflammation; particulate matter; air pollution
MeSH headings : Air Pollution / adverse effects; Animals; Cytokines / metabolism; Disease Susceptibility; Humans; Inflammation / etiology; Inflammation / metabolism; Inflammation / pathology; Inflammation Mediators / metabolism; Oxidation-Reduction; Oxidative Stress; Particulate Matter / adverse effects; Reactive Oxygen Species / metabolism
TL;DR:
Research is required to elucidate the exact mechanisms by which PM exposure results in adverse health effects, in terms of the relationship between the redox responses triggered by the presence of the particles and the inflammation observed in the different organs, so the development/exacerbation of PM-associated health problems can be prevented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 13, 2020
2020 journal article
Postexercise Inflammasome Activation and IL-1 beta Production Mitigated by Flavonoid Supplementation in Cyclists
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 30(6), 396–404.
author keywords: cytokines; gasdermin D; IL-18; inflammation
TL;DR:
The data indicate that 2-week FLAV ingestion mitigated inflammasome activation, with a corresponding decrease in IL-1β release in cyclists after a 75-km cycling time trial, and support the strategy of ingesting high amounts of FLAV to mitigate postexercise inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 9, 2020
2020 journal article
Proteomic pro fi ling reveals mitochondrial alterations in Rett syndrome
FREE RADICAL BIOLOGY AND MEDICINE, 155, 37–48.
MeSH headings : Gene Expression Profiling; Humans; Methyl-CpG-Binding Protein 2 / genetics; Mutation; Proteome / genetics; Proteomics; Rett Syndrome / genetics
TL;DR:
The proteomic analysis confirms the pathological relevance of mitochondrial dysfunction in RTT pathogenesis and progression and carries out the first comprehensive characterization of RTT cellular proteome, showing mainly changes in expression of proteins involved in the mitochondrial network.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 6, 2020
2020 journal article
Redox regulation of cutaneous inflammasome by ozone exposure
FREE RADICAL BIOLOGY AND MEDICINE, 152, 561–570.
MeSH headings : Caspase 1 / metabolism; Humans; Hydrogen Peroxide; Inflammasomes / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidation-Reduction; Ozone / toxicity; Reactive Oxygen Species
TL;DR:
It is demonstrated that O3 can activate cutaneous inflammasome in a redox dependent manner suggesting a possible role of this new pathway in pollution induced inflammatory skin conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 13, 2020
2020 journal article
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer's disease
GEROSCIENCE, 42(1), 159–167.
author keywords: Late-onset Alzheimer's disease; Mild cognitive impairment; Mixed dementia; Blood-based biomarkers; BACE1
MeSH headings : Alzheimer Disease / diagnosis; Amyloid Precursor Protein Secretases; Amyloid beta-Peptides; Aspartic Acid Endopeptidases; Biomarkers; Humans
TL;DR:
The data suggest that increased BACE1 activity in serum may represent a potential biomarker for LOAD, and additional studies are needed to confirm the usefulness of Bace1, alone or in combination with other markers, in discriminating patients and predicting LOAD onset and progression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, ORCID
Added: March 16, 2020
2020 article
Skin Health from the Inside Out
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 235–254.
author keywords: pollution; skin; diet; GI tract; inflammation; antioxidant; vitamins
MeSH headings : Antioxidants / metabolism; Humans; Reactive Oxygen Species / metabolism; Skin Physiological Phenomena
TL;DR:
This review discusses how topical application of antioxidants, including vitamins C and E, carotenoids, resveratrol, and pycnogenol, can be combined with dietary supplementation of these antioxidant compounds in addition to probiotics and essential minerals to protect against outdoor stressor-induced skin damage, including the damage associated with aging.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: April 27, 2020
2020 journal article
The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 685.
author keywords: NOX; NF-kappa B; Cyclin D1; Skin; p21
MeSH headings : Aldehydes / metabolism; Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin D1 / metabolism; Humans; Keratinocytes / drug effects; Lipid Peroxidation / drug effects; NADPH Oxidases / metabolism; Oxidative Stress / drug effects; Phosphodiesterase 4 Inhibitors / pharmacology; Phosphodiesterase 4 Inhibitors / toxicity; Psoriasis / drug therapy; Sulfonamides / pharmacology; Sulfonamides / toxicity; Transcription Factor RelA / metabolism; para-Aminobenzoates / pharmacology; para-Aminobenzoates / toxicity
TL;DR:
CHF6001 has the potential to treat skin disorders associated with hyperproliferative keratinocytes, such as psoriasis by targeting oxidative stress, abnormal re-epithelization, and inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: May 8, 2020
2019 journal article
13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation
FREE RADICAL BIOLOGY AND MEDICINE, 134, 598–603.
author keywords: Rett syndrome; Oxidative stress; Hydroxyoctadecadienoic acids; Inflammation; Omega-3 polyunsaturated fatty acids; Arachidonate 15-Lipoxygenase
MeSH headings : Adolescent; Adult; Arachidonate 15-Lipoxygenase / genetics; Arachidonate 15-Lipoxygenase / metabolism; Case-Control Studies; Child; Female; Humans; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Leukocytes, Mononuclear / metabolism; Linoleic Acids / metabolism; Linoleic Acids, Conjugated / metabolism; Male; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology; Young Adult
TL;DR:
Statistically significant correlation was demonstrated between the increased plasma HODEs levels and the lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, and the possible ability of omega-3 polyunsaturated fatty acids supplementation in improving the oxinflammation status in RTT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 1, 2019
2019 journal article
Antiglycative Activity and RAGE Expression in Rett Syndrome
CELLS, 8(2).
author keywords: methylglyoxal; glyoxalases; advanced glycation end products; MeCP2; dicarbonyl stress; fibroblasts
MeSH headings : Adolescent; Adult; Antigens, Neoplasm / metabolism; Cell Survival / drug effects; Child; Female; Fibroblasts / drug effects; Fibroblasts / metabolism; Glycosylation; Humans; Lactoylglutathione Lyase / metabolism; Mitogen-Activated Protein Kinases / metabolism; Pyruvaldehyde / pharmacology; Rett Syndrome / metabolism; Rett Syndrome / pathology; Thiolester Hydrolases / metabolism; Young Adult
TL;DR:
Besides OxInflammation, RTT is associated with reshaping of the major defense systems against dicarbonyl stress, along with an altered cellular stress response towards pro-glycating insults.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: March 25, 2019
2019 article
Blueberries Topical Application Prevents Ozone Induced Cutaneous Inflammasome Activation
Pambianchi, E., Francesca, F., Pecorelli, A., Woodby, B., Lila, M., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S148–S148.
Sources: Web Of Science, ORCID
Added: December 2, 2019
2019 journal article
Bone status in relation to ambulatory performance in girls with Rett syndrome: a 10-year longitudinal study
PEDIATRIC RESEARCH, 85(5), 639–643.
MeSH headings : Absorptiometry, Photon; Adolescent; Bone Density; Bone and Bones / diagnostic imaging; Bone and Bones / physiology; Child; Child Nutrition Sciences; Child, Preschool; Cholecalciferol / administration & dosage; Disabled Persons; Female; Finger Phalanges / diagnostic imaging; Follow-Up Studies; Fractures, Bone / diagnostic imaging; Humans; Infant; Longitudinal Studies; Nutritional Status; Rett Syndrome / diagnostic imaging; Rett Syndrome / physiopathology; Surveys and Questionnaires; Ultrasonography; Vitamin D / blood; Walking
TL;DR:
This longitudinal study suggests that both ambulatory and nonambulatory Rett subjects present a progressive deterioration of bone status as assessed by quantitative ultrasound parameters, and the ambulatory impairment and the nutritional status seem to play a key role in the deterioration ofBone status.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 9, 2019
2019 article
Comparing Skin Aging in Vitro Induced by External and Internal Cigarette Smoke Exposure
Prieux, R., Valacchi, G., Benedusi, M., & Cervellati, F. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S137–S137.
Sources: Web Of Science, ORCID
Added: December 2, 2019
2019 journal article
Conjugation of LasR Quorum-Sensing Inhibitors with Ciprofloxacin Decreases the Antibiotic Tolerance of P-aeruginosa Clinical Strains
JOURNAL OF CHEMISTRY, 2019.
TL;DR:
This work has identified, for the first time, a QSi conjugated with ciprofloxacin (ET37), that is able to reduce the formation of biofilm and the onset of tolerant clones in P. aeruginosaclinical strains and could have a wide application in clinical setting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 9, 2019
2019 journal article
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 183.
author keywords: Endocannabinoid system; Fatty acid amide hydrolase; Enzyme inhibitors; Selective inhibitors; Dopamine ligands; Polypharmacology; Multitarget compounds; Dopamine receptor ligands
MeSH headings : Amidohydrolases / antagonists & inhibitors; Amidohydrolases / metabolism; Binding, Competitive; Cell Line; Cell Survival / drug effects; Dopamine / metabolism; Endocannabinoids / metabolism; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Humans; Ligands; Piperazines / chemistry; Piperazines / pharmacology; Pyrroles / chemistry; Pyrroles / pharmacology
TL;DR:
The synthesis and biological characterization of compounds 5a-j inspired by the structure of the authors' potent and selective fatty acid amide hydrolase (FAAH) inhibitors and ligands of dopamine D2 or D3 receptor subtypes are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 16, 2019
2019 review
Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development
[Review of ]. MINERVA MEDICA, 110(3), 238–250.
author keywords: PON1 protein, human; Alzheimer's disease; Oxidative stress
MeSH headings : Alzheimer Disease / blood; Alzheimer Disease / epidemiology; Alzheimer Disease / etiology; Aryldialkylphosphatase / blood; Humans
TL;DR:
The possible link between PON1 with AD pathogenesis is discussed, eventual mechanistic pathways that could account from epidemiological observations are hypothesized and the methodological issue limitation in Pon1 studies is highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: May 6, 2019
2019 article
HGA Induces Oxidative Damage in an Ostcoblastic Cellular Model of Alkaptonuria: Sources and Mechanisms HGA Induces Oxidative Damage in an Osteoblastic Cellular Model of Alkaptonuria: Sources and Mechanisms
Schiavone, M. L., Pecorelli, A., Woodby, B., Ferrara, F., Santucci, A., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S37–S38.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: December 2, 2019
2019 review
Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage
[Review of ]. BIOFACTORS, 45(4), 536–547.
author keywords: ozone; particulate matter; cigarette smoke; peroxidation
MeSH headings : Air Pollutants / metabolism; Air Pollutants / toxicity; Aldehydes / metabolism; Aldehydes / toxicity; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / genetics; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Gene Expression Regulation / drug effects; Humans; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Oxidation-Reduction; Oxidative Stress; Ozone / metabolism; Ozone / toxicity; Particulate Matter / toxicity; Psoriasis / chemically induced; Psoriasis / genetics; Psoriasis / metabolism; Psoriasis / pathology; Reactive Oxygen Species / agonists; Reactive Oxygen Species / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Aging / drug effects; Skin Aging / genetics; Skin Aging / pathology; Tobacco Smoke Pollution / adverse effects; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
Increased levels of HNE in the skin, in response to pollutants, likely accelerates skin aging and exacerbates existing skin inflammatory conditions; thus, targeting HNE formation could be an innovative cosmeceutical approach for topical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 20, 2020
2019 journal article
Involvement of cutaneous SR-B1 in skin lipid homeostasis
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 666, 1–7.
author keywords: Scavenger receptor; Skin; Keratinocytes; Lipids; Ceramides; Cholesterol; Differentiation
MeSH headings : Cell Differentiation / physiology; Cells, Cultured; Filaggrin Proteins; Gene Expression Regulation; Homeostasis; Humans; Keratinocytes / cytology; Lipid Metabolism / genetics; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / physiology; Skin / cytology; Skin / metabolism
TL;DR:
One of the main functions of SR-B1 in the skin is to regulate ceramide levels and thereby maintain the barrier function of the skin, resulting in the protection of cutaneous tissues from outdoor insults.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: June 17, 2019
2019 journal article
Involvement of the TREK-1 channel in human alveolar cell membrane potential and its regulation by inhibitors of the chloride current
JOURNAL OF CELLULAR PHYSIOLOGY, 234(10), 17704–17713.
author keywords: 9-AC; A549 cells; ANO-6; DCPIB; K plus channels; pneumocytes
MeSH headings : A549 Cells; Alveolar Epithelial Cells / metabolism; Biological Transport / physiology; Cell Line, Tumor; Cell Membrane / metabolism; Cell Size; Chloride Channels / metabolism; Chlorides / metabolism; Humans; Membrane Potentials / physiology; Patch-Clamp Techniques / methods; Potassium Channels, Tandem Pore Domain / metabolism
TL;DR:
The identification of DCPIB and 9‐AC molecules as its activators suggests their possible use to build new pharmacological tools for the modulation of this channel and identifies the TREK‐1 channel as the presumable target of both drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 29, 2019
2019 journal article
Lipid nanostructures for antioxidant delivery: a comparative preformulation study
BEILSTEIN JOURNAL OF NANOTECHNOLOGY, 10, 1789–1801.
author keywords: alpha-tocopherol; cryogenic transmission electron microscopy (cryo-TEM); dermocosmetics; HO-1; nanostructured lipid carriers (NLCs); retinoic acid; skin pollution; solid lipid nanoparticles (SLNs)
TL;DR:
Interestingly, it was found that pretreatment with the nanoformulation resulted in significantly reduced heme oxygenase upregulation as compared to control samples, suggesting a protective effect provided by the nanoparticles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: September 16, 2019
2019 journal article
Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells
BIOFACTORS, 45(6), 920–929.
author keywords: apoptosis; ER stress; melanoma; mitochondria; protein synthesis; rottlerin
TL;DR:
In this cell line, rottlerin exhibits its main and newest cytotoxic properties, that is, growth arrest, apoptosis induction, and translation shutoff, and the drug markedly inhibited cell proliferation through cyclin D1 downregulation and induced apoptotic cell death as early as after 18 h treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 26, 2019
2019 article
OxInflammation as a Aossible new Player in Rett Syndrome Pathophysiology
Pecorelli, A., Valacchi, G., Cordone, V., & Hayek, J. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S149–S149.
Sources: Web Of Science, ORCID
Added: December 2, 2019
2019 review
Ozonated Oils and Cutaneous Wound Healing
[Review of ]. CURRENT PHARMACEUTICAL DESIGN, 25(20), 2264–2278.
author keywords: Cutaneous wound healing; ROS; peroxidation; topical application; ozonated oil; inflammation
MeSH headings : Humans; Ozone; Phytotherapy; Plant Oils / therapeutic use; Skin; Wound Healing
TL;DR:
The present review intends to summarize the actual state of the art of the topical usage of ozonated oil in cutaneous wounds with special emphasis to the importance of theozonated degree of the oil.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 7, 2019
2019 article
Redox Regulation of Cutaneous Inflammasome Pathway by Ozone Exposure
Ferrara, F., Pecorelli, A., Woodby, B., Pambianchi, E., Messano, N., Therrien, J. P., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S22–S23.
Sources: Web Of Science, ORCID
Added: December 2, 2019
2019 article
Redox-Regulation of Antimicrobial Peptides
Woodby, B., Pambianchi, E., Francesca, F., Messano, N., Pecorelli, A., Therrien, J. P., & Valacchii, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S54–S55.
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Sources: Web Of Science, ORCID
Added: December 2, 2019
2019 journal article
Skin damage by tropospheric ozone
HAUTARZT, 70(3), 163–168.
author keywords: Air pollution; Skin aging; Skin wrinkling; Oxidative stress; Peroxidation
MeSH headings : Air Pollutants / adverse effects; Air Pollution; Humans; Lipid Peroxidation / drug effects; Nitrogen Dioxide / analysis; Oxidative Stress; Ozone / adverse effects; Ozone / analysis; Particulate Matter / analysis; Public Health; Skin Aging / drug effects; Skin Aging / radiation effects; Ultraviolet Rays / adverse effects
TL;DR:
The experimental evidence suggests a positive correlation of O3 exposure with oxidative damage, impaired antioxidant defence and proinflammatory response in the skin, and skin might be a potentially overlooked target organ of ambient O3.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: March 25, 2019
2019 journal article
Trehalose inhibits cell proliferation and amplifies long-term temozolomide- and radiation-induced cytotoxicity in melanoma cells: A role for autophagy and premature senescence
JOURNAL OF CELLULAR PHYSIOLOGY, 234(7), 11708–11721.
author keywords: melanoma cells; trehalose; autophagy; premature senescence; radiosensitization
MeSH headings : Apoptosis / drug effects; Apoptosis / radiation effects; Autophagy / drug effects; Autophagy / radiation effects; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Proliferation / radiation effects; Cellular Senescence / drug effects; Cellular Senescence / radiation effects; Chloroquine / pharmacology; Drug Resistance, Neoplasm / drug effects; Humans; Melanocytes / drug effects; Melanocytes / metabolism; Melanocytes / pathology; Melanocytes / radiation effects; Melanoma / pathology; Melanoma / radiotherapy; Radiation, Ionizing; Sequestosome-1 Protein / metabolism; Temozolomide / pharmacology; Trehalose / pharmacology
TL;DR:
The results suggest that trehalose, a safe nutrient supplement able to cross the blood–brain barrier, is a promising candidate, worthy to be further explored in vivo, to augment the therapeutic efficacy of TMZ and RT in melanoma brain metastases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 22, 2019
2018 article
AtmO(3)spheric skin damage: The oxInflammation phenomena
Valacchi, G., Pecorelli, A., Pambianchi, E., Ferrara, F., & Lila, M. (2018, September). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 138, pp. B15–B15.
Sources: Web Of Science, ORCID
Added: October 19, 2018
2018 journal article
Circadian clock as possible protective mechanism to pollution induced keratinocytes damage
Mechanisms of Ageing and Development, 172, 13–20.
author keywords: Ozone (O-3); Oxidative stress; Circadian clock; Antioxidant pathway; Skin homeostasis
MeSH headings : ARNTL Transcription Factors / metabolism; Air Pollutants / toxicity; Cell Line; Circadian Clocks; Gene Expression Regulation / drug effects; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; NF-E2-Related Factor 2 / metabolism; Organ Specificity; Ozone / toxicity; Skin / metabolism; Skin / pathology
TL;DR:
This work investigated a possible protective role of entrained circadian clock to ozone induced damage in keratinocytes, the main cellular component of human epidermis, and showed that clock-synchronized keratinocyte compared to arrhythmic ones exhibited a more efficient antioxidant response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 journal article
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain
ChemMedChem, 13(19), 2090–2103.
author keywords: covalent inhibitors; endocannabinoid system; fatty acid amide hydrolase; neuropathic pain; serine hydrolase
MeSH headings : Amidohydrolases / antagonists & inhibitors; Animals; Benzodiazepinones / chemical synthesis; Benzodiazepinones / pharmacology; Benzodiazepinones / therapeutic use; Benzodiazepinones / toxicity; Cell Line, Tumor; Enzyme Inhibitors / chemical synthesis; Enzyme Inhibitors / pharmacology; Enzyme Inhibitors / therapeutic use; Enzyme Inhibitors / toxicity; Humans; Male; Mice; Molecular Docking Simulation; Molecular Structure; NF-kappa B / metabolism; Neuralgia / drug therapy; Oxidative Stress / drug effects; Structure-Activity Relationship
TL;DR:
A series of 12 new compounds characterized by functionalized tricyclic scaffolds developed, showing the ability to decrease oxidative stress by reducing the expression of the redox‐sensitive transcription factor NF‐κB and able to relieve the hypersensitivity induced by oxaliplatin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 article
Inflammasome involvement in Rett syndrome subclinical inflammation
Pecorelli, A., Cordone, V., Falone, S., Romani, A., Benedusi, M., Hayek, J., … Valacchi, G. (2018, November 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 128, pp. S108–S109.
TL;DR:
The results suggest a possible basal activation of inflammasome in RTT cells that, on the other hand, appear to be unable to respond properly at the inflammatory stimulus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: November 19, 2018
2018 journal article
Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure
MECHANISMS OF AGEING AND DEVELOPMENT, 172, 86–95.
author keywords: Air pollution; Particulate matter; Oxidative damage; Inflammation
MeSH headings : Cell Line, Transformed; Humans; Interleukin-1alpha / metabolism; Keratinocytes / metabolism; Keratinocytes / pathology; NF-E2-Related Factor 2 / metabolism; NF-kappa B / metabolism; Oxidation-Reduction / drug effects; Particulate Matter / toxicity
TL;DR:
Overall these data, suggest lipid and protein oxidative damage, as well as an increase of inflammatory response after being challenged with CAPs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Lifestyle determinants of healthy ageing in a Mediterranean population: The multinational MEDIS study
Experimental Gerontology, 110, 35–41.
author keywords: Healthy ageing; Longevity; Elderly; Health policy; Mediterranean
MeSH headings : Aged; Aged, 80 and over; Cardiovascular Diseases / epidemiology; Diet, Mediterranean; Exercise; Feeding Behavior; Female; Healthy Aging; Humans; Logistic Models; Longevity; Male; Mediterranean Region / epidemiology; Risk Factors; Smoking / epidemiology
TL;DR:
The gaps in the understanding of factors affecting longevity and healthy ageing remain; public health authorities and stakeholders should focus on the lifestyle determinants of healthy ageing, that seems to be an effective mean for improving older peoples' health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 journal article
Low-grade systemic inflammation is associated with functional disability in elderly people affected by dementia
GeroScience, 40(1), 61–69.
author keywords: Inflammation; Dementia; Alzheimer's disease; Mixed dementia; Functional abilities
MeSH headings : Activities of Daily Living; Aged; Aged, 80 and over; Aging / physiology; Alzheimer Disease / etiology; Alzheimer Disease / physiopathology; Analysis of Variance; C-Reactive Protein / metabolism; Case-Control Studies; Cognitive Dysfunction / etiology; Cognitive Dysfunction / physiopathology; Dementia / complications; Dementia / diagnosis; Disability Evaluation; Disease Progression; Female; Geriatric Assessment / methods; Homocysteine / metabolism; Humans; Inflammation / complications; Inflammation / diagnosis; Italy; Male; Reference Values; Retrospective Studies
TL;DR:
The data suggest that systemic low-grade inflammation may contribute to functional disability in older patients with dementia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 journal article
Mediterranean diet and depression among older individuals: The multinational MEDIS study
Experimental Gerontology, 110, 67–72.
author keywords: Mediterranean diet; Tea; Depression; Older adults
MeSH headings : Aged; Aged, 80 and over; Cross-Sectional Studies; Depression / epidemiology; Diet, Mediterranean; Female; Geriatric Assessment; Humans; Life Style; Logistic Models; Male; Mediterranean Region / epidemiology; Psychiatric Status Rating Scales; Risk Factors; Self Report; Tea
TL;DR:
Greater adherence to the MedDiet and daily tea drinking seem to have a beneficial effect on depressive symptoms in older adults.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 journal article
Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs “in vitro” wound closure
Mechanisms of Ageing and Development, 172, 78–85.
author keywords: Skin; Oxidative stress; Pollution; RHE; Wound healing; Particulate matter; Cigarette smoke; Ozone
MeSH headings : Cell Line, Transformed; Epidermis / metabolism; Epidermis / pathology; Gene Expression Regulation; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Scavenger Receptors, Class B / biosynthesis; Tobacco Smoke Pollution / adverse effects; Wound Healing
TL;DR:
The data obtained showed that not only cigarette, but also the other environmental stressors reduced SR-B1 expression in epidermal cutaneous tissues and that this effect might be involved in impaired wound healing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 journal article
Non-conventional rottlerin anticancer properties
Archives of Biochemistry and Biophysics, 645, 50–53.
MeSH headings : Acetophenones / pharmacology; Acetophenones / therapeutic use; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Benzopyrans / pharmacology; Benzopyrans / therapeutic use; Breast Neoplasms / drug therapy; Humans; Melanoma / drug therapy
TL;DR:
The major novelties highlighted in this mini review are the ability to bind and inhibit key molecules, such as ERK and mTOR, directly, thus independently of upstream signaling cascades, and to cause a profound dysregulation of cap-dependent protein translation through the mTORC1/4EBP1/eIF4E axis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 journal article
OXINFLAMMATION IN RETT SYNDROME
Pathophysiology, 25(3), 189.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 review
OxInflammation: From Subclinical Condition to Pathological Biomarker
[Review of ]. FRONTIERS IN PHYSIOLOGY, 9.
author keywords: biomarkers; neurological disorders; oxidative stress; inflammation mediators; NF kappa B
TL;DR:
The term “OxInflammation” is proposed as a novel operative term describing a permanent pro-oxidative feature that interact, in a positive feed-back manner, to a not yet clinically detectable inflammatory process, leading in a long run (chronically) to a systemic/local damage, as a consequence of the cross talk between inflammatory, and oxidative stress mediators.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2018 journal article
Role of Nrf2 in preventing oxidative stress induced chloride current alteration in human lung cells
Journal of Cellular Physiology, 233(8), 6018–6027.
author keywords: catalase; chloride current; ozone; patch clamp; redox imbalance; respiratory tract
MeSH headings : A549 Cells; Antioxidants / metabolism; Catalase / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cell Survival / physiology; Chloride Channels / metabolism; Chlorides / metabolism; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Gene Expression Regulation / drug effects; Gene Expression Regulation / physiology; Humans; Hydrogen Peroxide / pharmacology; Lung / drug effects; Lung / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / physiology; Ozone / pharmacology
TL;DR:
Patch clamp experiments bring new insights into the mechanisms involved in OS‐induced lung tissue damage, pointing out the role of H2O2 in chloride current alteration and the ability of Nfr2 activation in preventing this effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID
Added: January 25, 2020
2018 journal article
SR-B1 involvement in keratinocytes in vitro wound closure
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 658, 1–6.
author keywords: Wound healing; Skin; Proliferation; Migration
MeSH headings : Cell Line, Transformed; Cell Movement / physiology; Cell Proliferation / physiology; Cyclin D1 / metabolism; Gene Knockout Techniques; Humans; Keratinocytes / cytology; Keratinocytes / physiology; Matrix Metalloproteinase 9 / metabolism; NF-kappa B p50 Subunit / metabolism; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / physiology; Skin / metabolism; Wound Healing / physiology
TL;DR:
In vitro data demonstrated that SR-B1 influenced keratinocyte proliferation and migration through a downregulation of nuclear cyclin D1 levels and active MMP9 expression respectively possibly in an NF-kB-dependent mechanism, and suggests a new role of SRB1 as a possible new key player in cutaneous wound healing mechanism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 26, 2018
2018 article
Scavenger receptor B1 as a possible new player in cutaneous tissue proliferation and differentiation
Valacchi, G., Muresan, X., Belmonte, G., Pecorelli, A., & Gruber, F. (2018, September). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 138, pp. B25–B25.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID
Added: October 19, 2018
2018 journal article
Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells
FREE RADICAL BIOLOGY AND MEDICINE, 126, 287–295.
MeSH headings : A549 Cells; Aldehydes / metabolism; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Antioxidants / pharmacology; Biological Transport / drug effects; Catalase / genetics; Catalase / metabolism; Cell Survival / drug effects; Humans; Hydrogen Peroxide / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Oxidation-Reduction / drug effects; Oxidative Stress / drug effects; Ozone / pharmacology; Protein Processing, Post-Translational / drug effects; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / metabolism; Vitamin E / metabolism
TL;DR:
To characterize the molecular mechanism involved in the redox modulation of SRB1, its cellular levels were assessed in human alveolar epithelial cells after O3 exposure and it was demonstrated that O3 induced the loss ofSRB1 protein levels, a mechanism that could account for SRB 1 protein loss.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 16, 2018
2017 review
4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation
[Review of ]. FREE RADICAL BIOLOGY AND MEDICINE, 111, 270–280.
author keywords: Inflammation; Isoprostanes; Oxidative stress; Rare disease; Orphan disease; CDKL5; FOXG1; MecP2
MeSH headings : Aldehydes / metabolism; Brain / metabolism; Brain / pathology; Feedback, Physiological; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Humans; Inflammation; Isoprostanes / metabolism; Lipid Peroxidation / genetics; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mutation; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Oxidative Stress; Proteasome Endopeptidase Complex / metabolism; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology
TL;DR:
Aiming 4HNE as a therapeutic target could represent a coadjuvant treatment with some beneficial impact in these patients, in a pathology completely orphan of any therapy, with special emphasis on 4-hydroxynonenal (4HNE).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
First dual AK/GSK-3 beta inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 138, 438–457.
author keywords: Antioxidant agents; Glycogen synthase kinase 3 beta (GSK-3 beta); Adenosine kinase (AK); Dual inhibitors; Molecular docking
MeSH headings : Adenosine Kinase / antagonists & inhibitors; Adenosine Kinase / metabolism; Antioxidants / chemical synthesis; Antioxidants / chemistry; Antioxidants / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Humans; Hydrogen Peroxide / antagonists & inhibitors; Hydrogen Peroxide / pharmacology; Molecular Structure; Neuroblastoma / metabolism; Neuroblastoma / pathology; Neuroprotective Agents / chemical synthesis; Neuroprotective Agents / chemistry; Neuroprotective Agents / pharmacology; Oxidative Stress / drug effects; Protein Kinase Inhibitors / chemical synthesis; Protein Kinase Inhibitors / chemistry; Protein Kinase Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Structure-Activity Relationship
TL;DR:
The identification of compound 5l, as the first dual hAK/hGSK-3β inhibitor reported to date, holds promise for the development of new series of potential therapeutic agents for the treatment of neurodegenerative diseases characterized by an innovative pharmacological profile.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Is car use related with successful aging of older adults? Results from the multinational Mediterranean islands study
Annals of Epidemiology, 27(3), 225–229.
author keywords: Successful aging; Car use; Driving; Mediterranean islands; Older adults
MeSH headings : Aged; Aged, 80 and over; Aging / physiology; Aging / psychology; Automobile Driving / psychology; Automobile Driving / statistics & numerical data; Cross-Sectional Studies; Female; Greece; Humans; Male; Mediterranean Islands; Quality of Life / psychology; Rural Population / statistics & numerical data
TL;DR:
The activity of car use seems to be an indicator of quality of life among older adults, as measured through successful aging, as well as less prevalence of obesity and hypertension while were more physically active.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2020
2017 journal article
Mediterranean lifestyle and cardiovascular disease prevention
Cardiovascular Diagnosis and Therapy, 7, S39–47.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Modulation of Chloride Currents in Human Lung Epithelial Cells Exposed to Exogenous Oxidative Stress
JOURNAL OF CELLULAR PHYSIOLOGY, 232(7), 1817–1825.
MeSH headings : A549 Cells; Chloride Channels / metabolism; Electrophysiological Phenomena / drug effects; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Lung / pathology; Oxidative Stress / drug effects; Ozone / pharmacology; Patch-Clamp Techniques; Protective Agents / pharmacology; Vitamin E / pharmacology
TL;DR:
The data suggest that ozone exposure is able to modify chloride current density and the use of vitamin E can prevent the above‐mentioned damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Monoolein aqueous dispersions as a delivery system for quercetin
Biomedical Microdevices, 19(2).
author keywords: Quercetin; Monoolein aqueous dispersions (MAD); Monoolein; Antioxidant activity
MeSH headings : Antioxidants / chemistry; Antioxidants / toxicity; Cell Line; Drug Carriers / chemistry; Glycerides / chemistry; Humans; Kinetics; Quercetin / chemistry; Quercetin / toxicity; Water / chemistry
TL;DR:
Experiments on antioxidant activity of MAD containing QT demonstrated that their activity parallel with the content of encapsulated QT within the MAD formulations produced allow us to conclude that MAD can be potentially proposed for the delivery of QT.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 25, 2020
2017 journal article
Nanostructured lipid carriers (NLC) for the delivery of natural molecules with antimicrobial activity: production, characterisation and in vitro studies
Journal of Microencapsulation, 34(1), 63–72.
author keywords: Nanoparticles; nanotechnology; formulation; nanostructured lipid carriers
MeSH headings : Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacology; Bacteria / drug effects; Bacterial Infections / drug therapy; Cell Line; Cyanobacteria / drug effects; Drug Carriers / chemistry; Fungi / drug effects; Humans; Lipids / chemistry; Mycoses / drug therapy; Nanostructures / chemistry; Nanostructures / ultrastructure
TL;DR:
NLC loaded with active molecules showed a lower toxicity as compared to their free form on human cultured cells, and can be potentially proposed to control phytopathogenic organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2020
2017 journal article
Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation
Colloids and Surfaces B: Biointerfaces, 158, 441–452.
author keywords: Nanotechnology; Materials science; Formulation; Propolis by-product; Nanoparticles; Nanostructured lipid carriers; Propolis byproduct
MeSH headings : Drug Delivery Systems / methods; Lipids / chemistry; Nanoparticles / chemistry; Nanostructures / chemistry; Nanotechnology / methods; Propolis / chemistry; Wound Healing / physiology
TL;DR:
Solid lipid nanoparticles modified with propolis material provided an acceleration of the in vivo wound healing process and the drug entrapment efficiency from the nanoparticulate systems was investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2020
2017 journal article
Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study
MOLECULES, 22(12).
author keywords: anti-inflammatory; artificial tears; corneal epithelium; cyclin D1; dry eye syndrome; HA; HA-CL; IL-8; re-epithelialization
MeSH headings : Analysis of Variance; Biomarkers; Cell Line; Cell Survival; Cyclin D1 / metabolism; Drug Stability; Dry Eye Syndromes; Epithelium, Corneal / drug effects; Humans; Hyaluronic Acid / analysis; Hyaluronic Acid / chemistry; Hydrogen-Ion Concentration; Lubricant Eye Drops / analysis; Lubricant Eye Drops / chemical synthesis; Lubricant Eye Drops / chemistry; Lubricant Eye Drops / pharmacology; Re-Epithelialization / drug effects; Viscosity; Wound Healing / drug effects
TL;DR:
An in vitro evaluation of the re-epithelialization ability of two different preparations containing a recently synthetized HA cross-linked with urea showed no cellular toxicity, a slight decrease in IL-8 release, and restoration of epithelium integrity when the wounded 3D model was treated with S1 and S2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Paraoxonase, arylesterase and lactonase activities of paraoxonase-1 (PON1) in obese and severely obese women
Scandinavian Journal of Clinical and Laboratory Investigation, 78(1-2), 18–24.
author keywords: Arylesterase; body mass index; markers of oxidative stress; obesity; paraoxonase-1
MeSH headings : Anthropometry; Aryldialkylphosphatase / blood; Body Mass Index; Carboxylic Ester Hydrolases / blood; Female; Humans; Middle Aged; Obesity / blood; Obesity / enzymology; Regression Analysis
TL;DR:
The results suggest that the apparent obesity-associated decrement of PON1 activity might simply reflect the decrease in concentration of its plasmatic carrier.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: January 25, 2020
2017 journal article
Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017.
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Ascorbic Acid / chemistry; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Connexin 43 / genetics; Connexin 43 / metabolism; Humans; Melanoma / drug therapy; Melanoma / pathology; Microscopy, Electron, Scanning; Potassium / chemistry; Ribose / chemistry; Spheroids, Cellular / drug effects; Spheroids, Cellular / ultrastructure
TL;DR:
The results suggest that PAR could be used as a safe adjuvant approach in support to conventional therapies for the treatment of melanoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin
Journal of Investigative Dermatology, 137(6), 1373–1375.
MeSH headings : Administration, Topical; Antioxidants / therapeutic use; Ascorbic Acid / therapeutic use; Biopsy, Needle; Dermatitis / drug therapy; Dermatitis / etiology; Dermatitis / pathology; Environmental Exposure / adverse effects; Female; Humans; Immunohistochemistry; Male; Oxidative Stress / drug effects; Ozone / adverse effects; Reference Values; Risk Assessment; Treatment Outcome
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2020
2017 journal article
Resveratrol: from diet to topical usage
Food & Function, 8(11), 3879–3892.
MeSH headings : Animals; Cardiovascular Diseases / prevention & control; Cosmetics / analysis; Humans; Resveratrol; Skin / drug effects; Skin / metabolism; Stilbenes / metabolism; Stilbenes / pharmacology
TL;DR:
More basic research on the topical application of RESV should be performed to better understand the way it prevents cutaneous damage and whether it could be recommended as a preventive skin aging agent for all skin insults.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: January 25, 2020
2017 journal article
Retention of mitochondria in mature human red blood cells as the result of autophagy impairment in Rett syndrome
Scientific Reports, 7.
MeSH headings : Animals; Autophagosomes / pathology; Autophagy / genetics; Cells, Cultured; Cerebellum / pathology; Disease Models, Animal; Erythrocytes / cytology; Erythrocytes / metabolism; Erythrocytes / ultrastructure; Female; Fibroblasts; Healthy Volunteers; Humans; Male; Methyl-CpG-Binding Protein 2 / genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mutation; Primary Cell Culture; Protein Aggregates / genetics; Rett Syndrome / blood; Rett Syndrome / genetics; Rett Syndrome / pathology; Sequestosome-1 Protein / metabolism
TL;DR:
It is proposed that a defective autophagy could be involved in the RTT clinical phenotype, which introduces new molecular perspectives in the pathogenesis of the syndrome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2017 article
Serum from patients affected by Alzheimer disease shows a paraoxonase-dependent pro-apoptotic effect on endothelial cells
Crivellari, I., Cervellati, C., Dalla Sega, F. V., Valacchi, G., Trentini, A., Passaro, A., … Rizzo, P. (2017, July). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 108, pp. S93–S93.
TL;DR:
This data indicates that endothelial apoptosis is one of the hallmarks of ED, and serum from AD patients affects this death process in human umbilical vein endothelial cells (HUVEC), and cells treated with AD serum presented a significant response to in vitro assay.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome
Neuroscience Research, 105, 28–34.
author keywords: Protein glycosylation; Neurological disorders; Nucleotide pyrophosphatase; Mecp2
MeSH headings : Animals; Brain / metabolism; Glycosylation; Membrane Glycoproteins / metabolism; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mice, Mutant Strains; Pyrophosphatases / metabolism; Rett Syndrome / metabolism
TL;DR:
The findings indicate that there is a causal link between the amount of Mecp2 and the N-glycosylation of NPP-5, and that this link is likely to be causal for Rett syndrome.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
Association between siesta (daytime sleep), dietary patterns and the presence of metabolic syndrome in elderly living in Mediterranean area (MEDIS study): The moderating effect of gender
The Journal of Nutrition, Health & Aging, 21(10), 1118–1124.
author keywords: Metabolic syndrome; sleep; elderly; diet; lifestyle; MEDIS; siesta; mediterranean-type diet
MeSH headings : Aged; Aged, 80 and over; Cross-Sectional Studies; Energy Intake / physiology; Feeding Behavior / physiology; Female; Gender Identity; Humans; Life Style; Male; Mediterranean Islands; Metabolic Syndrome / epidemiology; Metabolic Syndrome / etiology; Prevalence; Sleep / physiology
TL;DR:
Lifestyle parameters including sleep and diet quality are strongly associated with the presence of MetS in elderly cohort, but different their level of influence appears to be different, depending on gender.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 21, 2021
2016 journal article
Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients
Cytokine, 77, 180–188.
author keywords: Rett syndrome; Autism spectrum disorders; Cytokine; Chemokine; Immune system; Peripheral blood mononuclear cells; Mitochondria
MeSH headings : Adolescent; Adult; Autistic Disorder / blood; Autistic Disorder / genetics; Child; Child, Preschool; Cytokines / blood; Cytokines / genetics; Gene Expression Profiling; Humans; Immunoenzyme Techniques / methods; Interleukin-13 / blood; Interleukin-13 / genetics; Interleukin-15 / blood; Interleukin-15 / genetics; Interleukin-1beta / blood; Interleukin-1beta / genetics; Interleukin-8 / blood; Interleukin-8 / genetics; Interleukin-9 / blood; Interleukin-9 / genetics; Leukocytes, Mononuclear / metabolism; Leukocytes, Mononuclear / ultrastructure; Microscopy, Electron, Transmission; Rett Syndrome / blood; Rett Syndrome / genetics; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A / blood; Vascular Endothelial Growth Factor A / genetics; Young Adult
TL;DR:
A possible role of immune dysfunction in RTT is indicated making the clinical features of this pathology related also to the immunology aspects, suggesting, therefore, novel possible therapeutic interventions for this disorder.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases
The International Journal of Biochemistry & Cell Biology, 81, 356–363.
author keywords: Paraoxonase-1; Arylesterase activity; Multiple sclerosis; Alzheimer's disease; Vascular dementia
MeSH headings : Aged; Aryldialkylphosphatase / blood; Aryldialkylphosphatase / metabolism; Biomarkers / blood; Biomarkers / metabolism; Carboxylic Ester Hydrolases / blood; Carboxylic Ester Hydrolases / metabolism; Dementia / blood; Dementia / diagnosis; Dementia / enzymology; Female; Humans; Male; Multiple Sclerosis / blood; Multiple Sclerosis / diagnosis; Multiple Sclerosis / enzymology; Multiple Sclerosis / physiopathology; Neurodegenerative Diseases / blood; Neurodegenerative Diseases / diagnosis; Neurodegenerative Diseases / enzymology; Neurodegenerative Diseases / metabolism; Risk Factors
TL;DR:
The data suggest that a depressed arylesterase activity could be a common denominator of different neurological diseases which, independently of their peculiar ethiopathogenesis and pathophysiology, appear to be all characterized by an altered systemic redox balance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress
ACS Chemical Neuroscience, 7(6), 737–748.
author keywords: TRPV1 ligands; capsaicin; antioxidant; oxidative stress; neuroprotective; antinociceptive
MeSH headings : Analgesics / pharmacology; Animals; CHO Cells; Capsaicin / pharmacology; Cricetulus / metabolism; Male; Models, Molecular; Oxidative Stress / drug effects; Rats, Wistar; TRPV Cation Channels / agonists; TRPV Cation Channels / metabolism; Thiophenes / chemical synthesis; Thiophenes / chemistry; Thiophenes / pharmacology
TL;DR:
4-(Thiophen-2-yl)butanoic acid was identified as a cyclic substitute of the unsaturated alkyl chain of the natural ligand, capsaicin and synthesized in good yield and high purity and their molecular recognition against the target was investigated by means of docking experiments followed by molecular dynamics simulations, in order to rationalize their geometrical and thermodynamic profiles.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 21, 2021
2016 journal article
Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing
Cancer Letters, 380(1), 106–113.
author keywords: Rottlerin; AMPK; mTOR; 4EBP-1; Autophagy; Protein synthesis
MeSH headings : Acetophenones / pharmacology; Adaptor Proteins, Signal Transducing / antagonists & inhibitors; Adaptor Proteins, Signal Transducing / metabolism; Antineoplastic Agents / pharmacology; Antineoplastic Agents / toxicity; Autophagy / drug effects; Benzopyrans / pharmacology; Cell Cycle Proteins; Cell Line; Dose-Response Relationship, Drug; Humans; Mechanistic Target of Rapamycin Complex 1; Melanoma / drug therapy; Melanoma / enzymology; Melanoma / pathology; Multiprotein Complexes / antagonists & inhibitors; Multiprotein Complexes / metabolism; Phosphoproteins / antagonists & inhibitors; Phosphoproteins / metabolism; Protein Biosynthesis / drug effects; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / toxicity; Protein Synthesis Inhibitors / pharmacology; Protein Synthesis Inhibitors / toxicity; Signal Transduction / drug effects; Skin Neoplasms / drug therapy; Skin Neoplasms / enzymology; Skin Neoplasms / pathology; TOR Serine-Threonine Kinases / antagonists & inhibitors; TOR Serine-Threonine Kinases / metabolism; Time Factors
TL;DR:
Western blotting analysis, caspase activity assay, nuclear imaging and the effects of autophagy, apoptosis and necroptosis inhibitors indicated that Rottlerin cytotoxicity was due to none of the aforementioned death mechanisms, but in growth arrested cells, the death did occur after a prolonged treatment and most likely ensued from the observed blockage of protein synthesis that reached levels expected to be incompatible with cell survival.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
OxInflammation in Rett syndrome
The International Journal of Biochemistry & Cell Biology, 81, 246–253.
author keywords: Rett syndrome; MECP2; Oxidative stress; Inflammation; Cytokines
MeSH headings : Humans; Inflammation / physiopathology; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Oxidative Stress; Rett Syndrome / physiopathology
TL;DR:
It is described and stimulated a new discussion on the idea that systemic subclinical inflammation and oxidative stress are crucial players of a detrimental vicious circle, driving the pathogenesis and clinical course of RTT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
Ozone mediators effect on “in vitro” scratch wound closure
Free Radical Research, 50(9), 1022–1031.
author keywords: Cutaneous tissues; wound healing; HNE; H2O2; oxidative stress
MeSH headings : Humans; Hydrogen Peroxide / metabolism; Oxidative Stress; Skin / drug effects; Wound Healing / physiology
TL;DR:
The present work suggests that ozonated saline effect on wound closure is the results of the combination of more molecules among which HNE and H2O2 play a key role.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application
Journal of Dermatological Science, 82(3), 209–212.
MeSH headings : Administration, Cutaneous; Antioxidants / administration & dosage; Antioxidants / pharmacology; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Drug Combinations; Environmental Exposure / adverse effects; Epidermis / drug effects; Epidermis / pathology; Humans; Models, Anatomic; Oxidants, Photochemical / toxicity; Ozone / toxicity; Sebum / drug effects; Vitamin E / administration & dosage; Vitamin E / pharmacology
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
Proteomic analysis of 4-hydroxynonenal and nitrotyrosine modified proteins in RTT fibroblasts
The International Journal of Biochemistry & Cell Biology, 81, 236–245.
author keywords: Oxidative stress; 4-hydroxynonenal; Nitric monoxide; Nitrotyrosine; Inducible nitric oxide synthase; Post-translational modification
MeSH headings : Aldehydes / chemistry; Aldehydes / metabolism; Blotting, Western; Case-Control Studies; Cells, Cultured; Female; Fibroblasts / chemistry; Fibroblasts / metabolism; Fibroblasts / pathology; Humans; Proteins / chemistry; Proteins / genetics; Proteome; Proteomics; Real-Time Polymerase Chain Reaction; Rett Syndrome / genetics; Rett Syndrome / physiopathology; Tyrosine / analogs & derivatives; Tyrosine / chemistry; Tyrosine / metabolism
TL;DR:
The evidence of a wide range of proteins able to forms adducts with 4-HNE, Nitrotyrosine or with both confirms the possible alteration of several aspects of cellular functions that well correlates to the complex clinical features of RTT patients.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
Redox regulation of inflammatory processes
The International Journal of Biochemistry & Cell Biology, 81, 234–235.
TL;DR:
This poster presents a probabilistic model of the response of the immune system to the presence of foreign substances, using a model derived from the model developed at the University of Ferrara in Italy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
Skeletal muscle mass and body fat in relation to successful ageing of older adults: The multi-national MEDIS study
Archives of Gerontology and Geriatrics, 66, 95–101.
author keywords: Successful ageing; Appendicular skeletal muscle mass; Body fat; Energy balance; Older adults
MeSH headings : Adipose Tissue; Aged; Aged, 80 and over; Aging; Body Composition; Body Mass Index; Cross-Sectional Studies; Energy Intake; Energy Metabolism; Feeding Behavior; Female; Greece / epidemiology; Humans; Male; Mediterranean Region / epidemiology; Muscle, Skeletal; Quality of Life; Sarcopenia / epidemiology
TL;DR:
Body composition changes seem to be associated with lower quality of life in the older adults, as measured through successful ageing, and results from sensitivity analysis showed that the effects of variations on body composition were consistent, less pronounced in the positive energy balance group and more pronounced among the oldest old.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 4, 2020
2016 journal article
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity
European Journal of Medicinal Chemistry, 109, 99–106.
author keywords: COX-2 inhibitors; 1,5-diarylpyrrole derivatives; Anti-inflammatory agents; Antinociceptive agents; Antiproliferative activity; Molecular modelling
MeSH headings : Adult; Analgesics / chemical synthesis; Analgesics / chemistry; Analgesics / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / therapeutic use; Cell Line; Cell Proliferation / drug effects; Cyclooxygenase 2 / metabolism; Cyclooxygenase 2 Inhibitors / chemical synthesis; Cyclooxygenase 2 Inhibitors / chemistry; Cyclooxygenase 2 Inhibitors / therapeutic use; Edema / drug therapy; Halogenation; Humans; Hyperalgesia / drug therapy; Models, Molecular; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / therapeutic use; Rats; Skin / drug effects; Skin / pathology; Skin Neoplasms / drug therapy; Skin Neoplasms / pathology
TL;DR:
A series of substituted 1,5-diarylpyrrole-3-alkoxyethyl ethers synthesized showed antiproliferative activity in the HaCaT (aneuploid immortal keratinocyte from adult human skin) cell models and exhibited a prominent in vivo anti-inflammatory and antinociceptive activities, in addition its antiprolifierative power in an in-vitro model of human skin cancer is herein described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 21, 2021
2016 journal article
Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late onset Alzheimer's disease (LOAD)
BBA Clinical, 5, 25–28.
author keywords: MCI; AD; Plasmalogens; DAG; Patient stratification
TL;DR:
These are the first serum biochemical data to stratify MCI and LOAD patients into 3 different patient cohorts within each clinical diagnosis, advancing efforts to biochemically define patient heterogeneity in cognitive disorders.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 4, 2020
2015 journal article
Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β
International Immunopharmacology, 28(1), 794–801.
author keywords: Chondrocyte; Osteoarthritis; Nitric oxide-selective cyclooxigenase-2 inhibitors; Cyclooxigenase inhibitor nitric oxide donors; Naproxen; VA694
MeSH headings : Aged; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cell Culture Techniques; Cell Survival / drug effects; Cells, Cultured; Chondrocytes / drug effects; Chondrocytes / immunology; Cyclooxygenase 2 / genetics; Dinoprostone / analysis; Dinoprostone / metabolism; Dose-Response Relationship, Drug; Gene Expression / drug effects; Humans; Interleukin-1beta / pharmacology; Matrix Metalloproteinases / genetics; Middle Aged; Molecular Structure; NF-kappa B / immunology; Naproxen / analogs & derivatives; Naproxen / chemistry; Naproxen / pharmacology; Nitrates / chemistry; Nitrates / pharmacology; Osteoarthritis, Hip / immunology; Pyrroles / chemistry; Pyrroles / pharmacology
TL;DR:
VA694, Naproxcinod and Naproxen, at both concentrations analyzed, significantly counteracted the negative effects induced by IL-1β, and suggest that these drugs exert anti-inflammatory and chondroprotective effects on OA chondROcytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 4, 2020
2015 journal article
Correction: Wound healing properties of hyaluronan derivatives bearing ferulate residues
Journal of Materials Chemistry B, 3(36), 7307–7307.
TL;DR:
Correction for 'Wound healing properties of hyaluronan derivatives bearing ferulate residues' by Giuseppe Valacchi et al., J. Mater Chem.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 4, 2020
2015 journal article
Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage
Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852(10), 2066–2074.
author keywords: Oxidative stress; NADPH oxidase; Glutathione peroxidase; Superoxide dismutase thioredoxin-reductases; 4HNE
TL;DR:
The findings suggest that the systemic OS levels in RTT can be a consequence of both: increased endogenous oxidants as well as altered mitochondrial biogenesis with a decreased activity of defensive enzymes that leads to posttranslational oxidant protein modification and a proteasome activity impairment.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 4, 2020
2015 journal article
NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy
Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852(3), 507–519.
author keywords: 4-Hydroxy-2-nonenal; Matrix metalloproteinase; NADPH oxidase; Aquaporin-4; Drug-resistant epilepsy
MeSH headings : Adolescent; Adult; Aldehydes / metabolism; Aquaporin 4 / metabolism; Astrocytes / metabolism; Astrocytes / pathology; Child, Preschool; Drug Resistance; Enzyme Activation; Epilepsy / mortality; Epilepsy / pathology; Female; Hippocampus / metabolism; Hippocampus / pathology; Humans; Lipid Peroxidation; Male; Membrane Glycoproteins / metabolism; NADPH Oxidase 2; NADPH Oxidases / metabolism; Neurodegenerative Diseases / metabolism; Neurodegenerative Diseases / pathology; Neurons / metabolism; Neurons / pathology; Superoxides / metabolism; Water-Electrolyte Balance
TL;DR:
It is suggested that seizure induces oxidative damage as well as neuronal loss, thereby promoting neuronal hyperexcitability, also affecting water and ion balance by AQP4 modulation, and thus generating a vicious cycle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID
Added: September 4, 2020
2015 journal article
Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin
Cancer Letters, 360(1), 17–27.
author keywords: Rottlerin; AMPK; mTOR; Raptor; Autophagy
MeSH headings : AMP-Activated Protein Kinases / metabolism; Acetophenones / pharmacology; Adenocarcinoma / enzymology; Adenocarcinoma / genetics; Adenocarcinoma / pathology; Antineoplastic Agents / pharmacology; Autophagy / drug effects; Benzopyrans / pharmacology; Breast Neoplasms / enzymology; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Female; Humans; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes / antagonists & inhibitors; Multiprotein Complexes / metabolism; Phosphorylation; Protein Kinase C-delta / metabolism; Protein Kinase Inhibitors / pharmacology; RNA Interference; Signal Transduction / drug effects; TOR Serine-Threonine Kinases / antagonists & inhibitors; TOR Serine-Threonine Kinases / genetics; TOR Serine-Threonine Kinases / metabolism; Time Factors; Transfection
TL;DR:
It is demonstrated that the Rottlerin-triggered autophagy is mediated by inhibition of mTORC1 activity through a novel AMPK and m TORC1 phosphorylation-independent mechanism, likely mediated by the direct interaction between Rottlersin and mTOR.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 4, 2020
2015 journal article
Protective Effect of Palmitoylethanolamide in a Rat Model of Cystitis
Journal of Urology, 193(4), 1401–1408.
author keywords: urinary bladder; cystitis; interstitial; palmidrol; cyclophosphamide; receptors; cannabinoid
MeSH headings : Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cyclophosphamide; Cystitis / chemically induced; Cystitis / prevention & control; Disease Models, Animal; Ethanolamines / therapeutic use; Female; Palmitic Acids / therapeutic use; Rats; Rats, Wistar
TL;DR:
There is strong evidence for a protective role of PEA as well as an alteration in bladder levels of P EA and of some of its targets in cyclophosphamide induced cystitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 4, 2020
2015 journal article
The Air Quality Health Index and Emergency Department Visits for Urticaria in Windsor, Canada
Journal of Toxicology and Environmental Health, Part A, 78(8), 524–533.
MeSH headings : Adolescent; Adult; Age Factors; Aged; Air Pollutants / analysis; Air Pollutants / toxicity; Air Pollution / adverse effects; Child; Emergency Service, Hospital; Environmental Exposure / adverse effects; Environmental Illness / chemically induced; Environmental Illness / epidemiology; Environmental Illness / therapy; Environmental Monitoring; Female; Hospitals, Urban; Humans; Infant; Male; Models, Biological; Nitrogen Dioxide / analysis; Nitrogen Dioxide / toxicity; Ontario / epidemiology; Oxidants, Photochemical / analysis; Oxidants, Photochemical / toxicity; Ozone / analysis; Ozone / toxicity; Particulate Matter / analysis; Particulate Matter / toxicity; Risk; Sex Characteristics; Urban Health; Urticaria / chemically induced; Urticaria / epidemiology; Urticaria / therapy
TL;DR:
Findings demonstrated associations between ambient air pollution and urticarial confirming that air pollution affects skin conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 4, 2020
2015 journal article
The effects of three different classes of anti-inflammatory agents on in vitro human osteoarthritic chondrocytes exposed to IL-1β
Osteoarthritis and Cartilage, 23, A159–A160.
Sources: Crossref, ORCID
Added: September 4, 2020
2015 journal article
Wound healing properties of hyaluronan derivatives bearing ferulate residues
Journal of Materials Chemistry B, 3(35), 7037–7045.
TL;DR:
The data presented herein suggest HAFA-17 as a possible future drug for the therapeutic treatment of acute and chronic wounds as well as in vitro and in vivo in preclinical models.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 4, 2020
2014 journal article
Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: Effects of omega-3 polyunsaturated fatty acid supplementation
Prostaglandins, Leukotrienes and Essential Fatty Acids, 91(5), 183–193.
author keywords: Omega-3 polyunsaturated fatty acids; Erythrocyte membrane; Inflammation; Isoprostanes; Rett syndrome
MeSH headings : Adolescent; Adult; Animals; Biomarkers / blood; Child; Child, Preschool; Dietary Supplements; Docosahexaenoic Acids / administration & dosage; Docosahexaenoic Acids / metabolism; Eicosapentaenoic Acid / administration & dosage; Eicosapentaenoic Acid / metabolism; Erythrocyte Membrane / drug effects; Erythrocyte Membrane / metabolism; Erythrocyte Membrane / pathology; Fatty Acids, Omega-3 / administration & dosage; Fatty Acids, Omega-3 / metabolism; Female; Humans; Inflammation / metabolism; Inflammation / pathology; Isoprostanes / blood; Lipids / blood; Rett Syndrome / diet therapy; Rett Syndrome / metabolism; Rett Syndrome / pathology
TL;DR:
Data indicate that a significant FAs abnormality is detectable in the RTT erythrocyte membranes and is partially rescued by ω-3 PUFAs, a beneficial effects of omega-3 polyunsaturated fatty acids on disease severity in RTT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2014 journal article
Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells
Toxicology in Vitro, 28(5), 999–1005.
author keywords: e-CIG vapor; Tobacco cigarette smoke; Skin and lung cells; Cytotoxicity; Cytokines release
MeSH headings : Cell Line; Cell Line, Tumor; Cell Survival / drug effects; Cytokines / metabolism; Electronic Nicotine Delivery Systems; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Flavoring Agents / toxicity; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Lung / cytology; Nicotine / toxicity; Smoke / adverse effects; Tobacco
TL;DR:
Exposure to e-CIG vapors results in far less toxic than exposure to CS, in fact, besides the deleterious effect of flavor and nicotine, even the humectants alone are able to evocate cytokines release.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2014 journal article
Effect of nanostructured lipid vehicles on percutaneous absorption of curcumin
European Journal of Pharmaceutics and Biopharmaceutics, 86(2), 121–132.
author keywords: Cubosomes; Organogel; Curcumin; Reflectance spectroscopy; Tape-stripping; Controlled release
MeSH headings : Adult; Chemistry, Pharmaceutical / methods; Curcumin / chemistry; Curcumin / metabolism; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Delivery Systems / methods; Epidermis / metabolism; Female; Gels / chemistry; Gels / metabolism; Glycerides / chemistry; Glycerides / metabolism; Humans; Lecithins / chemistry; Lecithins / metabolism; Lipids / chemistry; Male; Nanostructures / chemistry; Pharmaceutical Vehicles / chemistry; Pharmaceutical Vehicles / metabolism; Phospholipids / chemistry; Phospholipids / metabolism; Skin / metabolism; Skin Absorption
Sources: Crossref, ORCID
Added: September 11, 2020
2014 journal article
Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome
Neurobiology of Disease, 68, 66–77.
author keywords: Rett syndrome; Lipid peroxidation; Brain damage; Neurodevelopmental disorder; Murine models; Oxidative stress
MeSH headings : Aldehydes / metabolism; Analysis of Variance; Animals; Arachidonic Acid / metabolism; Brain Injuries / blood; Brain Injuries / etiology; Brain Injuries / pathology; Disease Models, Animal; Docosahexaenoic Acids / metabolism; Female; Gas Chromatography-Mass Spectrometry; Isoprostanes / metabolism; Male; Methyl-CpG-Binding Protein 2 / genetics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation / genetics; Nestin / genetics; Neuroprostanes / metabolism; Oxidative Stress / physiology; Rett Syndrome / blood; Rett Syndrome / complications; Rett Syndrome / genetics
TL;DR:
The present study indicates that oxidative brain damage is a previously unrecognized hallmark feature of murine RTT, and suggests that Mecp2 is involved in the protection of the brain from oxidative stress.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2014 journal article
Proteomic profiling and post-translational modifications in human keratinocytes treated with Mucuna pruriens leaf extract
Journal of Ethnopharmacology, 151(2), 873–881.
author keywords: Mucuna pruriens; Leaf extract; Keratinocytes; Proteomics; Oxidative stress
MeSH headings : Aldehydes / metabolism; Cell Line; Glucose Oxidase / pharmacology; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Mucuna; Oxidative Stress; Plant Extracts / pharmacology; Plant Leaves; Protein Binding; Protein Processing, Post-Translational / drug effects; Proteins / metabolism; Proteomics
TL;DR:
The findings show that MPME might be helpful in the treatment of OS-related skin diseases by preventing protein post-translational modifications (4-HNE PAs).
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2014 journal article
Resveratrol prevents cigarette smoke-induced keratinocytes damage
Food & Function, 5(9), 2348.
MeSH headings : Antioxidants / pharmacology; Cell Line; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Methionine Sulfoxide Reductases / genetics; Methionine Sulfoxide Reductases / metabolism; Oxidative Stress / drug effects; Protective Agents / pharmacology; Reactive Oxygen Species / metabolism; Resveratrol; Smoke / adverse effects; Stilbenes / pharmacology; Tobacco Products / adverse effects; Tobacco Products / analysis
TL;DR:
It is shown that resveratrol (at a dose of 10 μM) can decrease CS-induced ROS and carbonyl formation in human keratinocytes, and could increase the expression of MsrA, enzyme involved in cell defence against oxidative protein damage.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2014 journal article
Successful aging, dietary habits and health status of elderly individuals: A k-dimensional approach within the multi-national MEDIS study
Experimental Gerontology, 60, 57–63.
author keywords: Successful aging; Older adults; Dietary habits; Mediterranean; Health
MeSH headings : Aged; Aged, 80 and over; Aging; Diet, Mediterranean; Feeding Behavior; Female; Greece; Health Services for the Aged / statistics & numerical data; Health Status; Humans; Linear Models; Male; Mediterranean Islands
TL;DR:
Findings suggest that successful aging is a multidimensional and complex concept that exhibits gender heterogeneity, and annual use of health care services by the elders was found to be related to level of successful aging.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2013 journal article
Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes
European Journal of Pharmaceutical Sciences, 49(2), 133–141.
author keywords: COX-2 inhibitor; 1,5-Diarylpyrrole-3-alkopyrrole-3-alkoxyethyl ethers; Cyclin D1; p21
MeSH headings : Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 Inhibitors / pharmacology; Gene Expression / drug effects; Humans; Keratinocytes; NF-kappa B / metabolism; Pyrroles / pharmacology; RNA, Messenger / metabolism; Sulfones / pharmacology
TL;DR:
Compounds VA441 and VA428, along with their role in inhibiting COX-2 and inflammation, could have a possible therapeutic (topical and systemic) use against skin proliferative disorders, such as psoriasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2013 journal article
F2-Dihomo-isoprostanes and brain white matter damage in stage 1 Rett syndrome
Biochimie, 95(1), 86–90.
author keywords: MeCP2; Oxidative damage; Adrenic acid; F-2-Dihomo-isoprostanes; Total synthesis; Myelin damage; Autism spectrum disorders; Biomarkers
MeSH headings : Biomarkers / blood; Brain / drug effects; Brain / metabolism; Brain / pathology; Erucic Acids / chemistry; Erucic Acids / metabolism; F2-Isoprostanes / administration & dosage; F2-Isoprostanes / blood; F2-Isoprostanes / chemical synthesis; F2-Isoprostanes / pharmacokinetics; Fatty Acids, Unsaturated; Humans; Leukoencephalopathies / drug therapy; Leukoencephalopathies / metabolism; Leukoencephalopathies / pathology; Lipid Peroxidation / drug effects; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Myelin Sheath / chemistry; Myelin Sheath / pathology; Oxidative Stress; Rett Syndrome / blood; Rett Syndrome / diagnosis; Rett Syndrome / pathology
TL;DR:
Data indicate for the first time that quantification of F(2)-Dihomo-IsoPs in plasma represents an early marker of the disease and may provide a better understanding of the pathogenic mechanisms behind the neurological regression in patients with RTT.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2013 journal article
Incorporation of quercetin in respirable lipid microparticles: Effect on stability and cellular uptake on A549 pulmonary alveolar epithelial cells
Colloids and Surfaces B: Biointerfaces, 112, 322–329.
author keywords: Quercetin; Pulmonary delivery; Lipid microparticles; Alveolar epithelial cells; Stability; Cellular uptake
MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / cytology; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Antioxidants / administration & dosage; Antioxidants / pharmacokinetics; Biological Transport, Active; Cell Line; Cell Survival / drug effects; Drug Carriers / chemistry; Drug Compounding; Drug Stability; Humans; Lipids / chemistry; Particle Size; Quercetin / administration & dosage; Quercetin / pharmacokinetics
TL;DR:
Viability studies performed by lactate dehydrogenase assay demonstrated that quercetin LMs showed no significant cytotoxicity on the A549 cells, over the concentration 0.1-5μM, and the enhanced intracellular delivery of quercets achieved by the LMs is likely due to the flavonoid stabilization after encapsulation.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2013 journal article
NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells
Toxicology and Applied Pharmacology, 267(1), 30–40.
author keywords: Keap1; Ozone; 4-hydroxynonenal; Hydrogen peroxyde; Heme oxygenase-1
MeSH headings : Cell Line; Dose-Response Relationship, Drug; Endothelium, Vascular / cytology; Endothelium, Vascular / drug effects; Endothelium, Vascular / metabolism; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / blood; Homeostasis / drug effects; Humans; NF-E2-Related Factor 2 / blood; NF-E2-Related Factor 2 / physiology; Oxidation-Reduction / drug effects; Ozone / toxicity; Serum / metabolism; Serum / physiology; Up-Regulation / drug effects; Up-Regulation / physiology
TL;DR:
New insight is provided on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonation autohemotherapy, targeted to the restoration of redox homeostasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2013 journal article
Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic autism
Brain and Development, 35(2), 146–154.
author keywords: Neurodevelopment disorders; Oxidative stress; Free iron; Lipid peroxidation; 4-hydroxynonenal protein adducts
MeSH headings : Adolescent; Adult; Aldehydes / blood; Autistic Disorder / blood; Blotting, Western; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diagnostic and Statistical Manual of Mental Disorders; Erythrocyte Membrane / chemistry; Erythrocytes / chemistry; Female; Glutathione / blood; Humans; Intelligence Tests; Male; Neuropsychological Tests; Nonheme Iron Proteins / blood; Oxidative Stress / physiology; Plasma / chemistry; Young Adult
TL;DR:
An impairment of the redox status in classic autism patients is indicated, with a consequent imbalance between oxidative stress and antioxidant defences, potentially contributing to the autistic phenotype.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2013 journal article
Ozonated oils as functional dermatological matrices: Effects on the wound healing process using SKH1 mice
International Journal of Pharmaceutics, 458(1), 65–73.
author keywords: Wound healing; 1,2,4-Trioxolane moiety; Prodrugs; Vegetable matrices
MeSH headings : Animals; Collagen / metabolism; Female; Mice; NF-kappa B / metabolism; Plant Oils / pharmacology; Proliferating Cell Nuclear Antigen / metabolism; Skin / drug effects; Skin / metabolism; Vascular Endothelial Growth Factor A / metabolism; Wound Healing / drug effects
TL;DR:
Only treatment with ozonated sesame oil shows a faster wound closure in the first 7 days, paralleled with the increased VEGF and PCNA levels, NFκB nuclear translocation and 4-HNE formation.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2013 journal article
Scavenger receptor B1 post-translational modifications in Rett syndrome
FEBS Letters, 587(14), 2199–2204.
author keywords: Oxidative stress; 4-Hydroxynonenal; Ubiquitination; Protein adducts; HDL; Cholesterol
MeSH headings : Adolescent; Adult; Aldehydes / metabolism; Case-Control Studies; Cells, Cultured; Child; Female; Fibroblasts / metabolism; Humans; Lipid Peroxidation; Lipids / blood; Oxidative Stress; Rett Syndrome / metabolism; Scavenger Receptors, Class B / metabolism; Ubiquitination; Young Adult
TL;DR:
These findings show for the first time a loss of SRB1 in RTT cells and its relationship with a chronic oxidative stress status.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2012 journal article
Modulation of skin oxidative stress and inflammatory markers by environmental stressors. Differences between young and old
Journal of Dermatological Science, 65(3), 226–228.
MeSH headings : Aging / metabolism; Aging / pathology; Aldehydes / metabolism; Animals; Biomarkers / metabolism; Heme Oxygenase-1 / metabolism; Inflammation / physiopathology; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Mice; Mice, Inbred Strains; Models, Animal; NADPH Oxidases / metabolism; Oxidative Stress / physiology; Ozone / adverse effects; Skin / metabolism; Skin / pathology; Skin / physiopathology; Smoking / adverse effects
TL;DR:
In conclusion, epidermogenesis in a skin wound, in the absence of a well-developed BM, results in altered skin homeostasis with an activated epidermis and myofibroblast differentiation, and this results in hypertrophic scar or keloid formation.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2012 journal article
Morphological changes and oxidative damage in Rett Syndrome erythrocytes
Biochimica Et Biophysica Acta (BBA) - General Subjects, 1820(4), 511–520.
author keywords: Rett syndrome; Erythrocytes; Oxidative stress; Hypoxemia; F-2-Isoprostanes; Non protein-bound iron
MeSH headings : Adolescent; Adult; Biomarkers / blood; Cell Hypoxia; Cell Shape; Child; Child, Preschool; Erythrocytes / cytology; Erythrocytes / metabolism; F2-Isoprostanes / blood; Fatty Acids, Omega-3 / administration & dosage; Female; Glutathione / blood; Humans; Hypoxia; Oxidation-Reduction; Oxidative Stress; Oxygen; Pulmonary Gas Exchange; Rett Syndrome / blood; Rett Syndrome / genetics; Young Adult
TL;DR:
Findings indicate that in RTT RBCs shape is altered, the OS-hypoxia diad is critical in generating altered R BCs shape and membrane damage, and ω-3 PUFAs are able to partially rescue RBC’s morphology and theOS-derived damage.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2012 journal article
Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil
Genes & Nutrition, 7(3), 447–458.
author keywords: Rett syndrome; MeCP2; Oxidative Stress; omega-3 polyunsaturated fatty acids; Isoprostanes; Nonprotein bound iron; Antioxidants
TL;DR:
For the first time, these findings strongly suggest that a dietary intervention in this genetic disease at an early stage of its natural history can lead to a partial clinical and biochemical rescue.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2012 journal article
The Magic Velvet Bean of Mucuna pruriens
Journal of Traditional and Complementary Medicine, 2(4), 331–339.
TL;DR:
In this review, M. pruriens has been shown to have anti-parkinson and neuroprotective effects, which may be related to its anti-oxidant activity.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2011 journal article
Cigarette smoke exposure causes changes in Scavenger Receptor B1 level and distribution in lung cells
The International Journal of Biochemistry & Cell Biology, 43(7), 1065–1070.
author keywords: Cigarette smoke; Scavenger Receptor B1; Lung; Vitamin E; Ubiquitination
MeSH headings : Animals; Biological Transport / drug effects; Cell Line, Tumor; Cell Membrane / metabolism; Humans; Immunohistochemistry; Lung / cytology; Lung Neoplasms / etiology; Mice; Microscopy, Confocal; RNA, Messenger / genetics; RNA, Messenger / metabolism; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / metabolism; Smoking / adverse effects; Time Factors; Tocopherols / metabolism; Ubiquitination / drug effects
TL;DR:
Exposure to cigarette smoke induced changes in both sub-cellular redistribution and ubiquitination of Scavenger Receptor B1 together with in vivo data provides evidence that cigarette smoke exposure may alter lung's ability to control its tocopherol levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2011 journal article
F4-neuroprostanes mediate neurological severity in Rett syndrome
Clinica Chimica Acta, 412(15-16), 1399–1406.
author keywords: Rett syndrome; MeCP2; CDKL5; Neuroprostanes; Autism spectrum disorders; omega-3 polyunsaturated fatty acids
MeSH headings : Adult; Biomarkers / blood; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Disease Progression; Female; Humans; Isoprostanes / blood; Methyl-CpG-Binding Protein 2 / genetics; Mutation; Neurologic Examination; Rett Syndrome / blood; Rett Syndrome / diagnosis; Young Adult
TL;DR:
Quantification of plasma F₄-NeuroPs provides a novel RTT marker, related to neurological symptoms severity, mutation type and clinical presentation, and response to ω-3 PUFAs supplementation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2011 journal article
Increased levels of 4HNE-protein plasma adducts in Rett syndrome
Clinical Biochemistry, 44(5-6), 368–371.
author keywords: Rett syndrome; MeCP2; CDKL5; FOXG1; Oxidative stress; 4-Hydroxynonenal
MeSH headings : Adolescent; Adult; Aldehydes / blood; Blotting, Western; Child; Child, Preschool; Disease Progression; Forkhead Transcription Factors / genetics; Humans; Mutation; Nerve Tissue Proteins / genetics; Rett Syndrome / blood; Rett Syndrome / pathology; Young Adult
TL;DR:
Under the OS point of view FOXG1-related RTT appears to be distinct from the MeCP2/CDKL5, suggesting a distinct mechanism involved in its pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2011 journal article
Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice
Genes & Nutrition, 7(2), 319–329.
author keywords: Ginsenosides; Apoptosis; Apo E KO mice; LPO; NF kappa B; MAPK; Caspase; Cleaved PARP; Bcl-2; Hyperlipidemia
TL;DR:
Different combinational treatment of PD and PT extracts might ameliorate the liver inflammation and apoptosis in hyperlipidemic apo E KO mice, which is atherosclerotic animal model.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 21, 2021
2010 journal article
Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes
Toxicology and Applied Pharmacology, 248(3), 285–292.
author keywords: Catalase; CYP; Cytokine; Fatty acid; Gene polymorphism; GST
MeSH headings : Adult; Aged; Cytochrome P-450 Enzyme System / blood; Cytochrome P-450 Enzyme System / genetics; Cytokines / blood; Female; Gene Expression Profiling / methods; Gene Frequency / genetics; Humans; Male; Middle Aged; Multiple Chemical Sensitivity / blood; Multiple Chemical Sensitivity / diagnosis; Multiple Chemical Sensitivity / genetics; Oxidation-Reduction / drug effects; Polymorphism, Genetic / genetics; Xenobiotics / adverse effects; Xenobiotics / blood; Young Adult
TL;DR:
Altered redox and cytokine patterns suggest inhibition of expression/activity of metabolizing and antioxidant enzymes in MCS, and metabolic parameters indicating accelerated lipid oxidation, increased nitric oxide production and glutathione depletion in combination with increased plasma inflammatory cytokines should be considered.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2010 journal article
Novel PKCs activate ERK through PKD1 in MCF-7 cells
In Vitro Cellular & Developmental Biology - Animal, 47(1), 73–81.
author keywords: MCF-7 cells; PKC; Raf-1; RKIP; PKD; RIN1; ERK
TL;DR:
It is found that nPKCs activate ERK through transphosphorylation of PKD1, the blockage of which prevented PMA-stimulated ERK activation in MCF-7 cells.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 21, 2021
2010 journal article
The Physiological Behaviour of IMR-32 Neuroblastoma Cells is Affected by a 12-h Hypoxia/24-h Reoxygenation Period
Neurochemical Research, 35(11), 1691–1699.
author keywords: Hypoxia; Neuroblastoma cells; [Ca2+](i); Desferoxamine-chelatable free iron; F2-isoprostanes; ERK proteins; Oxidative stress
MeSH headings : Adenosine Triphosphate / metabolism; Aldehydes / metabolism; Calcium / metabolism; Cell Hypoxia / physiology; Cell Line, Tumor; Cell Survival; F2-Isoprostanes / metabolism; Humans; Iron / metabolism; Membrane Potential, Mitochondrial / drug effects; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Neuroblastoma / metabolism; Nitric Oxide / metabolism; Oxygen / metabolism; Oxygen / pharmacology; Protein Carbonylation
TL;DR:
The results indicate that 2% O2 hypoxia induces variations of NO and [Ca2+]i with subsequent mitochondrial depolarization, and it is responsible for oxidative stress, represented by increased free iron and F2-isoprostane, protein carbonyls and 4 hydroxynonenal protein adducts levels.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2009 journal article
Endothelin receptor A expression in human inflammatory cells
Regulatory Peptides, 158(1-3), 1–5.
author keywords: Endothelin; Neutrophils; Macrophages; Inflammation
MeSH headings : Base Sequence; Blotting, Western; Cell Line, Tumor; DNA Primers; Endothelin-1 / metabolism; Humans; Immunohistochemistry; Macrophages / metabolism; Neutrophils / metabolism; Receptor, Endothelin A / metabolism; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Considering that the overproduction of ET-1 following endothelial dysfunction and inflammation, contributes to pathophysiological processes such as vascular hypertrophy, cell proliferation and fibrosis, the results suggest that PMNs and MØs can also play a key role in vascular dysfunctions via the possible formation of an autocrine loop betweenET-1 and ET(A).
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2009 journal article
Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells
Toxicology in Vitro, 23(3), 365–370.
author keywords: Ozone; IL-8; TEMPO; Lung
MeSH headings : Cell Line, Tumor; Cell Survival / drug effects; Cyclic N-Oxides / pharmacology; Free Radical Scavengers / pharmacology; Free Radicals; Gene Expression / drug effects; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Lung Neoplasms / drug therapy; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Oxidants, Photochemical / toxicity; Ozone / toxicity; RNA, Messenger / metabolism; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism; Respiratory Mucosa / pathology
TL;DR:
Evidence that TEMPO reacts with O(3) and/or its cytotoxic products and may provide protections against O(2,2,6,6-tetramethylpiperidine-N-oxyl)-induced biotoxicities is provided.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2008 journal article
Antiproliferative and Survival Properties of PMA in MCF-7 Breast Cancer Cell
Cancer Investigation, 26(1), 13–21.
MeSH headings : Blotting, Western; Breast Neoplasms / metabolism; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Enzyme Activation / drug effects; Enzyme Inhibitors / pharmacology; Extracellular Signal-Regulated MAP Kinases / drug effects; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Flavonoids / pharmacology; Fluorescent Antibody Technique; Gene Expression / drug effects; Humans; Immunohistochemistry; Phorbol Esters / pharmacology; Proliferating Cell Nuclear Antigen / drug effects; Proliferating Cell Nuclear Antigen / metabolism; Signal Transduction / drug effects; Tetradecanoylphorbol Acetate / pharmacology; Tumor Suppressor Protein p53 / drug effects; Tumor Suppressor Protein p53 / metabolism; p21-Activated Kinases / drug effects; p21-Activated Kinases / metabolism
TL;DR:
It is concluded that PMA inhibits MCF-7 cell growth and simultaneously stimulates cell survival; both responses are linked to ERK-dependent and p53-independent p21 induction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2008 journal article
Effects of dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short-term cigarette smoke exposures
Genes & Nutrition, 4(1).
author keywords: beta-Carotene; Lycopene; Cigarette smoke; Lung inflammation; Oligonucleotide arrays; Granulocytes; C57BL/6 mice
TL;DR:
The data suggest that mice offer a viable in vivo model for studying bioactivities of dietary CARs and their modulatory effects on lung genomic expression in both health and after exposure to CS toxicants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: January 21, 2021
2008 journal article
Rottlerin inhibits the nuclear factor κB/Cyclin-D1 cascade in MCF-7 breast cancer cells
Life Sciences, 82(11-12), 638–643.
author keywords: Rottlerin; MCF-7 cells; cyclin-D1; NF kappa B; CaMKII
MeSH headings : Acetophenones / metabolism; Acetophenones / pharmacology; Benzopyrans / metabolism; Benzopyrans / pharmacology; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism; Cell Line, Tumor / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin D1 / genetics; Cyclin D1 / metabolism; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Humans; Indoles / metabolism; Indoles / pharmacology; Maleimides / metabolism; Maleimides / pharmacology; NF-kappa B / metabolism; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction / physiology
TL;DR:
Preliminary evidence is provided that the interference on the NFkappaB activation process likely occurs at the level of calcium/calmodulin-dependent protein kinase II (CaMKII), a known Rottlerin target, and the drug prevented calcium-induced CaMKII autophosphorylation which, in turn, led to decreased NFkakuB activation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2008 journal article
Severe Vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model
Free Radical Research, 42(4), 387–396.
author keywords: eosinophils; allergic inflammation; asthma; cytokines; IgE; vitamin E
MeSH headings : Animals; Asthma / genetics; Asthma / metabolism; Asthma / pathology; Bronchial Hyperreactivity / metabolism; Carrier Proteins / genetics; Eosinophils / metabolism; Gene Expression Regulation; Immunoglobulin E / blood; Inflammation; Interleukin-5 / metabolism; Lung / pathology; Mice; Mice, Knockout; Ovalbumin / chemistry; Oxidative Stress; Vitamin E Deficiency / complications
TL;DR:
It was concluded that the initial stimulation of immune responses by the TTP−/− mice were generally blunted compared to the T TP+/+ mice, thus diminishing some aspects of subsequent allergic inflammatory processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 11, 2020
2007 journal article
Cutaneous MMPs are differently modulated by environmental stressors in old and young mice
Toxicology Letters, 173(2), 73–79.
author keywords: ozone; UV; cigarette smoke; skin; MMPs; TIMPs
MeSH headings : Aging / metabolism; Animals; Enzyme Induction; Extracellular Matrix / metabolism; Female; Matrix Metalloproteinase 12 / biosynthesis; Matrix Metalloproteinase 2 / biosynthesis; Matrix Metalloproteinase 9 / biosynthesis; Matrix Metalloproteinases / biosynthesis; Mice; Mice, Hairless; Oxidants, Photochemical / pharmacology; Oxidative Stress; Ozone / pharmacology; Skin / drug effects; Skin / enzymology; Skin / radiation effects; Smoke / adverse effects; Tissue Inhibitor of Metalloproteinase-1 / metabolism; Tissue Inhibitor of Metalloproteinase-2 / metabolism; Tobacco; Ultraviolet Rays
TL;DR:
The ability of certain environmental pollutants to affect the ECM turnover through modulation of specific MMPs is demonstrated, and the higher susceptibility of old subjects to exogenous pro-oxidant insults is confirmed.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2007 journal article
Lung vitamin E transport processes are affected by both age and environmental oxidants in mice☆
Toxicology and Applied Pharmacology, 222(2), 227–234.
author keywords: vitamin E; lung; ozone; cigarette smoke; aging
MeSH headings : ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters / genetics; ATP-Binding Cassette Transporters / metabolism; Aging; Animals; Biological Transport / drug effects; Blotting, Western; CD36 Antigens / genetics; CD36 Antigens / metabolism; Female; Gene Expression Profiling / methods; Lipoproteins / blood; Lung / drug effects; Lung / metabolism; Mice; Mice, Hairless; Oxidants, Photochemical / chemistry; Oxidants, Photochemical / pharmacology; Ozone / pharmacology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / metabolism; Smoke; Tobacco / chemistry; Vitamin E / metabolism
TL;DR:
It is suggested that both age and environmental oxidant exposure affect pathways related to lung AT homeostasis and do so in a way that favors declines in lung AT.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2006 journal article
Modulation of cutaneous wound healing by ozone: Differences between young and aged mice
Toxicology Letters, 160(2), 127–134.
author keywords: aging; ozone; wound healing; TGF beta; NF kappa B; lipid peroxidation
MeSH headings : Aging / physiology; Aldehydes / analysis; Aldehydes / chemistry; Animals; Cross-Linking Reagents / analysis; Cross-Linking Reagents / chemistry; Female; I-kappa B Proteins / biosynthesis; Lipid Peroxidation / drug effects; Mice; Mice, Hairless; Models, Animal; NF-KappaB Inhibitor alpha; Ozone / toxicity; Protein Binding; Proteins / analysis; Proteins / chemistry; Skin / drug effects; Skin / injuries; Skin / metabolism; Transforming Growth Factor beta / biosynthesis; Wound Healing / drug effects
TL;DR:
The hypothesis that oxidant pollutant exposure and age interact so as to disrupt normal wound healing processes is supported.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
2004 journal article
Enhanced inflammatory responses in α-tocopherol transfer protein null mice
Archives of Biochemistry and Biophysics, 423(1), 162–169.
author keywords: alpha-tocopherol; alpha-TTP; oxidative stress; heme oxygenase-1; immune response
MeSH headings : Animals; Carrier Proteins / genetics; Carrier Proteins / metabolism; Female; Gene Deletion; Heme Oxygenase (Decyclizing) / metabolism; Heme Oxygenase-1; Inflammation / genetics; Inflammation / metabolism; Liver / metabolism; Lung / metabolism; Male; Membrane Proteins; Mice; Nitrates / metabolism; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase / metabolism; Nitric Oxide Synthase Type II; Nitrites / metabolism; RNA, Messenger / metabolism; Vitamin E / metabolism
TL;DR:
It is demonstrated that α-tocopherol is important for proper modulation of inflammatory responses and that sub-optimal α-ocopherol concentrations may derange inflammatory–immune responses.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2020
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