Gregory Wilkerson

Works (7)

Updated: June 3rd, 2024 08:15

2024 journal article

Structurally divergent and recurrently mutated regions of primate genomes

CELL, 187(6).

By: Y. Mao *, W. Harvey *, D. Porubsky *, K. Munson *, K. Hoekzema *, A. Lewis *, P. Audano *, A. Rozanski * ...

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Source: Web Of Science
Added: May 28, 2024

2023 journal article

Exclusion of Horizontal and Vertical Transmission as Major Sources of Trypanosoma cruzi Infections in a Breeding Colony of Rhesus Macaques (Macaca mulatta)

COMPARATIVE MEDICINE, 73(3), 229–241.

By: W. Kiehl*, C. Hodo *, G. Hamer *, S. Hamer & G. Wilkerson n

author keywords: Abbreviations; DTU; discrete typing unit; TAM; T; cruzi -associated monkey
TL;DR: Limiting contact with vectors, rather than segregation of infected macaques, is a key strategy for disease prevention at institutions that house macaques outdoors in the southern United States. (via Semantic Scholar)
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Added: August 21, 2023

2023 article

Frequency Variation and Dose Modification of Benznidazole Administration for the Treatment of Trypanosoma cruzi Infection in Mice, Dogs, and Nonhuman Primates

Bustamante, J. M., White, B. E., Wilkerson, G. K., Hodo, C. L., Auckland, L. D., Wang, W., … Tarleton, R. L. (2023, April 11). ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.

By: J. Bustamante *, B. White *, G. Wilkerson*, C. Hodo *, L. Auckland *, W. Wang*, S. McCain, S. Hamer *, A. Saunders *, R. Tarleton *

author keywords: Trypanosoma cruzi; Chagas disease; benznidazole; cure; dogs; nonhuman primates
MeSH headings : Mice; Dogs; Humans; Animals; Trypanocidal Agents / therapeutic use; Trypanocidal Agents / pharmacology; Chagas Disease / drug therapy; Chagas Disease / parasitology; Trypanosoma cruzi; Nitroimidazoles / therapeutic use; Nitroimidazoles / pharmacology; Clinical Protocols; Primates; Mammals
TL;DR: It is demonstrated that twice-weekly administration of BNZ for more than 4 months at doses that are ~2.5-fold that of previously used daily dosing protocols, provided the best chance to obtain parasitological cure. (via Semantic Scholar)
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Added: May 1, 2023

2023 article

Gastrointestinal tract pathology of the owl monkey (<i>Aotus</i> spp.)

Hensel, M. E., Rodrigues-Hoffmann, A., Dray, B. K., Wilkerson, G. K., Baze, W. B., Sulkosky, S., & Hodo, C. L. (2023, October 13). VETERINARY PATHOLOGY.

By: M. Hensel *, A. Rodrigues-Hoffmann *, B. Dray *, G. Wilkerson n, W. Baze*, S. Sulkosky, C. Hodo *

author keywords: Aotus spp.; gastrointestinal; intestinal incarceration; owl monkey
TL;DR: Evidence of spontaneous lesions in the species that contribute to morbidity and mortality in owl monkeys is provided. (via Semantic Scholar)
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Added: November 6, 2023

2023 article

Identification of constrained sequence elements across 239 primate genomes

Kuderna, L. F. K., Ulirsch, J. C., Rashid, S., Ameen, M., Sundaram, L., Hickey, G., … Farh, K. K.-H. (2023, November 29). NATURE.

By: L. Kuderna *, J. Ulirsch *, S. Rashid*, M. Ameen*, L. Sundaram *, G. Hickey *, A. Cox *, H. Gao * ...

TL;DR: A whole-genome alignment of 239 species is constructed, representing nearly half of all extant species in the primate order and highlighting the important role of recent evolution in regulatory sequence elements differentiating primates, including humans, from other placental mammals. (via Semantic Scholar)
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Added: March 25, 2024

2023 journal article

The landscape of tolerated genetic variation in humans and primates

SCIENCE, 380(6648), 929-+.

By: H. Gao *, T. Hamp*, J. Ede *, J. Schraiber *, J. McRae *, M. Singer-Berk *, Y. Yang*, A. Dietrich * ...

MeSH headings : Animals; Humans; Base Sequence; Gene Frequency; Genetic Variation; Primates / genetics; Whole Genome Sequencing
TL;DR: This resource is used to classify 6% of all possible human protein-altering variants as likely benign and impute the pathogenicity of the remaining 94% of variants with deep learning, achieving state-of-the-art accuracy for diagnosing pathogenic variants in patients with genetic diseases. (via Semantic Scholar)
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Added: August 7, 2023

2022 journal article

Primate hemorrhagic fever-causing arteriviruses are poised for spillover to humans

CELL, 185(21), 3980-+.

By: C. Warren *, S. Yu *, D. Peters *, A. Barbachano-Guerrero *, Q. Yang *, B. Burris*, G. Worwa *, I. Huang* ...

MeSH headings : Animals; Arterivirus / physiology; Hemorrhagic Fevers, Viral / veterinary; Hemorrhagic Fevers, Viral / virology; Humans; Macaca; Primates; Viral Zoonoses; Virus Internalization; Virus Replication
TL;DR: It is found that CD163 acts as an intracellular receptor for simian hemorrhagic fever virus (SHFV), a rare mode of virus entry that is shared with other hemorrhagic Fever-causing viruses (e.g., Ebola and Lassa viruses). (via Semantic Scholar)
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Added: November 28, 2022

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