Works (121)

Updated: April 4th, 2024 01:39

2023 journal article

Milk residues following multiple doses of meloxicam and gabapentin in lactating dairy cattle

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(12), 1873–1879.

By: D. Mzyk n, C. Giles n, R. Baynes n & G. Smith n

author keywords: meloxicam; gabapentin; lactation; postpartum; dairy cattle
TL;DR: Results of this study suggest that milk from cows treated with multiple doses of meloxicam alone or in combination with gabapentin will have low drug concentrations and falls below the reported limit of detection formeloxicam or gABapentin 120 and 60 hours respectively, following the final dose regardless of their stage of lactation. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 1, 2024

2022 personal communication

Letter to the editor: Comments on Schalich et al. (2021), Colostrum testing with Brix is a valuable on-farm tool. doi.org/10.193/jas/skab083

Lombard, J., Quigley, J., Haines, D., Garry, F., Earleywine, T., Urie, N., … Sockett, D. (2022, April 1).

By: J. Lombard, J. Quigley*, D. Haines*, F. Garry*, T. Earleywine, N. Urie, M. Chamorro*, S. Godden* ...

MeSH headings : Animals; Body Fluids; Colostrum; Dairying; Farms; Female; Immunodiffusion / veterinary; Pregnancy
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 16, 2022

2022 journal article

The pharmacokinetics of transdermal flunixin in lactating dairy goats

JOURNAL OF DAIRY SCIENCE, 105(1), 549–559.

By: E. Meira n, E. Wiloch n, E. Nixon n, J. Yeatts n, F. Sheela n, G. Smith n, R. Baynes n

author keywords: transdermal flunixin; goat; pharmacokinetics; drug residue; milk
MeSH headings : Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Clonixin / analogs & derivatives; Female; Goats; Lactation; Milk / chemistry
TL;DR: Evaluated the pharmacokinetics of transdermal flunixin in dairy goats to determine a milk withdrawal interval (WDI) to avoid violative residue contamination in the food supply and propose safe residue levels in goat milk provides a milk WDI of 60 h using the US Food and Drug Administration tolerance limit method. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 17, 2021

2021 journal article

Effects of different blood buffers administered in electrolyte solution to grain-fed veal calves experiencing diarrhea

JOURNAL OF DAIRY SCIENCE, 104(1), 957–962.

By: D. Wood, R. Blome, L. Ribeiro, A. Keunen, B. Keunen, G. Smith n, D. Renaud*

author keywords: diarrhea; electrolytes; blood buffers; calf
MeSH headings : Animal Feed / analysis; Animals; Body Weight; Cattle; Cattle Diseases / drug therapy; Diarrhea / drug therapy; Diarrhea / veterinary; Diet / veterinary; Electrolytes / therapeutic use; Feces; Male; Milk; Sodium Acetate / therapeutic use; Sodium Bicarbonate / therapeutic use
TL;DR: Although a severe dehydration challenge was not present, which should be considered a limitation of the study, MBP improved the acid-base status of calves compared with BBP, whereas HAL performed similarly to MBP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021

2021 review

Intravenous and Oral Fluid Therapy in Neonatal Calves With Diarrhea or Sepsis and in Adult Cattle

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 7.

By: P. Constable*, F. Trefz*, I. Sen*, J. Berchtold*, M. Nouri*, G. Smith n, W. Gruenberg

author keywords: osmolality; alkalosis; acidosis; fluid therapy; acid– base balance; oral electrolyte solution
TL;DR: Important components of an OES for neonatal calves are osmolality, sodium concentration, the effective SID that reflects the concentration of alkalinizing agents, and the energy content. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021

2020 journal article

Consensus recommendations on calf- and herd-level passive immunity in dairy calves in the United States

JOURNAL OF DAIRY SCIENCE, 103(8), 7611–7624.

By: J. Lombard*, N. Urie*, F. Garry*, S. Godden*, J. Quigley*, T. Earleywine, S. McGuirk*, D. Moore* ...

author keywords: colostrum; passive immunity; morbidity; standard
MeSH headings : Animals; Animals, Newborn / immunology; Cattle / immunology; Colostrum / immunology; Consensus; Female; Immunity, Herd; Immunoglobulin G / blood; Male; Pregnancy; United States
TL;DR: A group of calf experts were assembled to evaluate current data and determine if changes to the passive immunity standards were necessary to reduce morbidity and possibly mortality in preweaned dairy calves. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020

2020 journal article

Efficacy and production benefits following use of eprinomectin extended-release injection in pastured dairy heifers

VETERINARY PARASITOLOGY, 282.

By: H. Dudley n & G. Smith n

author keywords: Eprinomectin; Dairy; Nematodes; Anthelmintics
MeSH headings : Animals; Anthelmintics / administration & dosage; Cattle; Delayed-Action Preparations / administration & dosage; Female; Haemonchiasis / drug therapy; Haemonchus / drug effects; Injections, Subcutaneous / veterinary; Ivermectin / administration & dosage; Ivermectin / analogs & derivatives; Ostertagia / drug effects; Ostertagiasis / drug therapy; Trichostrongyloidea / drug effects; Trichostrongyloidiasis / drug therapy
TL;DR: The results of this study indicate that a single dose of extended-release eprinomectin was sufficient to control parasites through a 123-day summer grazing season and that administration of the anthelmintic had a significant impact on weight gain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 21, 2020

2019 journal article

Comparison of oral, intravenous, and subcutaneous fluid therapy for resuscitation of calves with diarrhea

JOURNAL OF DAIRY SCIENCE, 102(12), 11337–11348.

By: V. Dore n, D. Foster n, H. Ru n & G. Smith n

author keywords: dehydration; acidosis; osmotic diarrhea; oral electrolyte solution (OES); subcutaneous fluid therapy
MeSH headings : Administration, Intravenous; Animals; Animals, Newborn; Body Weight; Cattle; Cattle Diseases / drug therapy; Cattle Diseases / therapy; Dehydration / therapy; Dehydration / veterinary; Diarrhea / therapy; Diarrhea / veterinary; Electrolytes / administration & dosage; Feces; Fluid Therapy / veterinary; Infusions, Subcutaneous; Osmolar Concentration; Plasma Volume; Saline Solution, Hypertonic / administration & dosage; Saline Solution, Hypertonic / therapeutic use
TL;DR: In conclusion, oral electrolyte products remain the gold standard for resuscitating diarrheic calves with moderate dehydration and acidemia and will likely perform better than small volumes of IV lactated Ringer's solution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 chapter

Diseases of the Hepatobiliary System

In B. P. Smith, D. C. Van Metre, & N. Pusterla (Eds.), Large Animal Internal Medicine (6th ed., pp. 921–955). St. Louis: Elsevier.

By: G. Smith & J. Davis

Ed(s): B. Smith, D. Van Metre & N. Pusterla

Source: NC State University Libraries
Added: August 30, 2019

2019 journal article

Exploratory cohort study to determine if dry cow vaccination with a Salmonella Newport bacterin can protect dairy calves against oral Salmonella challenge

Journal of Veterinary Internal Medicine, 33(4), 1796–1806.

By: D. Foster n, M. Jacob n, D. Stowe n & G. Smith n

author keywords: calves; colostrum; passive immunity; Salmonella
MeSH headings : Animals; Animals, Newborn / immunology; Bacterial Vaccines / administration & dosage; Cattle; Cattle Diseases / immunology; Cattle Diseases / microbiology; Cattle Diseases / prevention & control; Cohort Studies; Colostrum; Female; Immunity, Maternally-Acquired; Male; Salmonella Infections, Animal / immunology; Salmonella Infections, Animal / prevention & control; Salmonella Vaccines / administration & dosage; Salmonella enterica / immunology; Salmonella typhimurium / physiology; Vaccination / veterinary
TL;DR: Transfer of colostral immunoglobulins from Salmonella enterica serotype Newport bacterin to neonatal calves was not sufficient to decrease mortality, clinical signs, sepsis, intestinal damage, or fecal shedding when exposed to a highly pathogenic Salmonellosis isolate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID, Web Of Science
Added: August 21, 2019

2019 journal article

Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves

PLOS ONE, 14(6).

By: D. Mzyk n, C. Bublitz n, M. Martinez*, J. Davis*, R. Baynes n & G. Smith n

Ed(s): D. Gladue

MeSH headings : Age Factors; Animals; Area Under Curve; Bronchoalveolar Lavage Fluid / chemistry; Cattle; Cattle Diseases / drug therapy; Disaccharides / administration & dosage; Disaccharides / pharmacokinetics; Extracellular Fluid / chemistry; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / pharmacokinetics; Pasteurella Infections / drug therapy; Pasteurella Infections / veterinary; Pasteurella multocida / pathogenicity; Respiration Disorders / drug therapy; Respiration Disorders / veterinary
TL;DR: Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters and potential reasons for age-related differences on plasma concentration–time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 30, 2019

2019 chapter

Manifestations and management of disease in neonatal ruminants

In B. P. Smith, D. C. Van Metre, & N. Pusterla (Eds.), Large Animal Internal Medicine (6th ed., pp. 335–381). St. Louis: Elsevier.

By: J. House, G. Smith, A. Gunn, S. McGuirk & M. Izzo

Ed(s): B. Smith, D. Van Metre & N. Pusterla

Source: NC State University Libraries
Added: August 30, 2019

2018 journal article

Automation and applications of the tolerance limit method in estimating meat withdrawal periods for veterinary drugs

COMPUTERS AND ELECTRONICS IN AGRICULTURE, 146, 125–135.

By: O. Udiani n, S. Mason*, G. Smith n, D. Mzyk n, R. Gehring*, L. Tell*, J. Riviere n, R. Baynes n

author keywords: Withdrawal time calculator; R studio; Maximum residue limit; Tolerance; US FDA
TL;DR: A novel program provides a platform to calculate a withdrawal period recommendation for any drug in any class of animal for various regulatory body standards and could be very helpful in cases of extra-label drug use in food animals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2018 chapter

Dosage forms and veterinary feed directives

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (10th ed., pp. 1459–1464). Wiley-Blackwell Publishing.

By: G. Smith & J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 30, 2019

2018 journal article

Effect of age on plasma protein binding of several veterinary drugs in dairy Check for calves 2

RESEARCH IN VETERINARY SCIENCE, 121, 59–64.

By: D. Mzyk n, C. Bublitz n, G. Hobgood n, M. Martinez*, J. Davis*, G. Smith n, R. Baynes n

author keywords: Protein binding; Calves; Alpha-1-acid glycoprotein; Albumin
MeSH headings : Age Factors; Animals; Blood Proteins / metabolism; Cattle / metabolism; Protein Binding; Veterinary Drugs / metabolism
TL;DR: Findings from these calves suggest that age is not an important factor in the binding of these drugs to plasma proteins, and statistically significant age-effects on plasma protein binding were not observed for any of the drugs evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 17, 2018

2018 journal article

Effect of age on the pharmacokinetics and distribution of tulathromycin in interstitial and pulmonary epithelial lining fluid in healthy calves

American Journal of Veterinary Research, 79(11), 1193–1203.

By: D. Mzyk*, C. Bublitz, G. Hobgood, M. Martinez, G. Smith* & R. Baynes

MeSH headings : Animals; Anti-Bacterial Agents / pharmacokinetics; Bronchoalveolar Lavage Fluid; Cattle; Disaccharides / pharmacokinetics; Extracellular Fluid / drug effects; Heterocyclic Compounds / pharmacokinetics; Lung / metabolism; Male
TL;DR: It is suggested that age affected multiple pharmacokinetic parameters of tulathromycin, likely owing to physiologic changes as calves mature from preruminants to ruminants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2019

2018 article

Fumonisins

VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES, 3RD EDITION, pp. 1003–1018.

By: G. Smith*

Sources: Web Of Science, NC State University Libraries
Added: April 15, 2019

2018 article

Slaframine

VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES, 3RD EDITION, pp. 1029–1032.

By: G. Smith*

Sources: Web Of Science, NC State University Libraries
Added: April 15, 2019

2017 journal article

Cerebral Disorders of Calves

VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 33(1), 27-+.

By: V. Dore n & G. Smith n

author keywords: Hypernatremia; Sodium toxicity; Polioencephalomalacia; Meningitis; Neurology
MeSH headings : Animals; Brain Diseases / diagnosis; Brain Diseases / therapy; Brain Diseases / veterinary; Cattle; Cattle Diseases / diagnosis; Cattle Diseases / therapy; Encephalomalacia / diagnosis; Encephalomalacia / therapy; Encephalomalacia / veterinary; Hypernatremia / diagnosis; Hypernatremia / therapy; Hypernatremia / veterinary; Meningitis, Bacterial / diagnosis; Meningitis, Bacterial / therapy; Meningitis, Bacterial / veterinary; Prognosis
TL;DR: The most common diseases affecting the cerebrum of calves with a focus on pathophysiology, diagnosis, and treatment are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Considerations for extralabel drug use in calves

Journal of the American Veterinary Medical Association, 250(11), 1275–1282.

By: D. Mzyk*, R. Gehring, L. Tell, T. Vickroy, J. Riviere*, G. Ragan, R. Baynes*, G. Smith*

MeSH headings : Animals; Animals, Newborn; Cattle; Drug Labeling; Drug Residues; Food Contamination; Meat; Milk; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: The purpose of this digest is to provide veterinarians with a summary of the considerations for ELDU in both beef and dairy calves as well as calves intended for veal production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 chapter

Disease prevention and control for the dairy heifer

In Large Dairy Herd Management (pp. 445–456).

By: G. Smith*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 19, 2019

2017 review

Invited review: Abomasal emptying in calves and its potential influence on gastrointestinal disease

[Review of ]. JOURNAL OF DAIRY SCIENCE, 100(1), 17–35.

By: J. Burgstaller*, T. Wittek* & G. Smith n

author keywords: abomasum; bloat; tympany; milk replacer; osmolality
MeSH headings : Abomasum / physiology; Absorption, Physiological; Acetaminophen / metabolism; Animals; Cattle; Cattle Diseases / etiology; Cattle Diseases / physiopathology; Female; Gastric Emptying; Gastrointestinal Diseases / etiology; Gastrointestinal Diseases / physiopathology; Gastrointestinal Diseases / veterinary; Ultrasonography / methods; Ultrasonography / veterinary; Xylose / metabolism
TL;DR: Both intrinsic and extrinsic factors controlling abomasal emptying include meal volume, energy density, and osmolality along with the content and source of protein in the calf including those that would be appropriate for use under field conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Pharmacokinetics and distribution in interstitial and pulmonary epithelial lining fluid of danofloxacin in ruminant and preruminant calves

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(2), 179–191.

By: D. Mzyk n, R. Baynes n, K. Messenger n, M. Martinez* & G. Smith n

MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Body Fluids / chemistry; Cattle / physiology; Digestion / physiology; Fluoroquinolones / chemistry; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life
TL;DR: Comparison of active drug concentrations in the plasma vs. different effector compartments of healthy preruminating and ruminating calves found that ruminant calves maintained higher ISF/plasma concentration ratios throughout the study period compared to that observed in preruminant calves. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 chapter

Actinobacillosis

In Merck Veterinary Manual (11th ed., pp. 589–590). Merck and Company.

By: G. Smith

Source: NC State University Libraries
Added: September 29, 2019

2016 chapter

Actinomycosis

In Merck Veterinary Manual (11th ed., pp. 590–592). Merck and Company.

By: G. Smith

Source: NC State University Libraries
Added: September 29, 2019

2016 journal article

Health concerns and management of select veterinary drug residues

Food and Chemical Toxicology, 88, 112–122.

By: R. Baynes n, K. Dedonder*, L. Kissell n, D. Mzyk n, T. Marmulak*, G. Smith n, L. Tell*, R. Gehring*, J. Davis n, J. Riviere*

author keywords: Drug; Veterinary; Residue; Adverse; Livestock
MeSH headings : Animals; Carcinogens; Drug Residues / adverse effects; Humans; Veterinary Drugs / chemistry; Veterinary Drugs / metabolism; Veterinary Drugs / pharmacokinetics
TL;DR: The aim of this manuscript is to review the potential adverse health effects in humans if exposed to residues of selected veterinary drugs used in food-producing animals and how regulatory and independent organizations manage the risk of these veterinary drugs based on data from human health risk assessments. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Pharmacokinetics and tissue elimination of flunixin in veal calves

American Journal of Veterinary Research, 77(6), 634–640.

By: L. Kissell n, P. Brinson n, R. Gehring*, L. Tell, S. Wetzlich*, R. Baynes n, J. Riviere*, G. Smith n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Cattle / blood; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / chemistry; Clonixin / metabolism; Clonixin / pharmacokinetics; Drug Residues; Half-Life; Liver / chemistry; Muscle, Skeletal / chemistry; Muscle, Skeletal / metabolism
TL;DR: Results indicated that a slaughter withdrawal interval of several weeks may be necessary to ensure that violative tissue residues of flunixin are not detected in veal calves treated with that drug. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Antimicrobial Decision Making for Enteric Diseases of Cattle

VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 31(1), 47-+.

By: G. Smith n

author keywords: Antimicrobials; Calf diarrhea; Diarrhea; Pharmacology; Salmonella
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Cattle; Cattle Diseases / diagnosis; Cattle Diseases / microbiology; Cattle Diseases / prevention & control; Dairying / methods; Decision Making; Diarrhea / microbiology; Diarrhea / prevention & control; Diarrhea / veterinary; Female; Veterinary Medicine / methods
TL;DR: Existing data on the use of antibiotics given to cattle with enteric diseases is reviewed to decide when they are necessary and which antimicrobials should be used. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Characterization of the serologic response induced by vaccination of late-gestation cows with a Salmonella Dublin vaccine

Journal of Dairy Science, 98(4), 2529–2532.

By: G. Smith n, F. Smith*, S. Zuidhof* & D. Foster n

author keywords: calf; colostrum; immunoglobulin G; Salmonella Dublin; passive immunity
MeSH headings : Animals; Antibodies, Bacterial / immunology; Cattle / immunology; Cattle Diseases / immunology; Cattle Diseases / prevention & control; Colostrum / immunology; Diarrhea / veterinary; Enzyme-Linked Immunosorbent Assay / veterinary; Female; Lactation; Pregnancy; Pregnancy Complications / immunology; Salmonella Vaccines; Salmonella enterica / immunology; Vaccination / veterinary
TL;DR: It is demonstrated that the use of a commercially available Salmonella Dublin vaccine can stimulate antibodies that are passed on to the calf via colostral transfer, and further studies need to be done to determine whether these antibodies will offer protection against Salmoneella challenge. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2015 journal article

Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 246(1), 118–125.

By: L. Kissell n, T. Leavens n, R. Baynes n, J. Riviere n & G. Smith n

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Cephalosporins / therapeutic use; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Female; Mastitis, Bovine / drug therapy; Mastitis, Bovine / metabolism; Milk / chemistry
TL;DR: Pharmacokinetics and elimination of flunixin and 5-hydroxy flunxin in milk differed between mastitic and healthy cows, resulting in violative residues, which may partially explain the high number of fl unixin residues reported in beef and dairy cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 chapter

Diseases of the Hepatobiliary System

In Large Animal Internal Medicine (5th ed.). St. Louis, MO: Elsevier Publishing.

Geof Smith

Ed(s): G. Smith

Source: NC State University Libraries
Added: February 12, 2021

2015 journal article

Effect of supplementing pasteurized milk balancer products to heat-treated whole milk on the growth and health of dairy calves

JOURNAL OF DAIRY SCIENCE, 98(2), 1127–1135.

By: K. Glosson n, B. Hopkins n, S. Washburn n, S. Davidson n, G. Smith n, T. Earleywine, C. Ma n

author keywords: dairy calf; milk balancer
MeSH headings : Animals; Body Weight; Cattle / growth & development; Cattle / physiology; Colostrum; Dairying; Diet / veterinary; Dietary Supplements; Feces; Female; Food Handling / methods; Hot Temperature; Milk; Pasteurization; Pregnancy; Weaning
TL;DR: The enhanced calf-feeding programs evaluated in this study were successful in increasing growth in preweaned calves when supplementing milk balancer product to heat-treated whole milk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Short communication: Pharmacokinetics of intramammary hetacillin in dairy cattle milked 3 times per day

Journal of Dairy Science, 98(3), 1856–1861.

By: D. Lindquist n, R. Baynes n & G. Smith n

author keywords: hetacillin; intramammary; pharmacokinetics; mastitis
MeSH headings : Ampicillin / analysis; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Cattle / metabolism; Dairying / methods; Female; Lactation; Mammary Glands, Animal / drug effects; Mastitis, Bovine / drug therapy; Microbial Sensitivity Tests; Milk / chemistry; Penicillins / administration & dosage; Penicillins / pharmacokinetics
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 31(9), 1506–1521.

By: T. Leavens n, L. Tell, L. Kissell*, G. Smith*, D. Smith, S. Wagner, W. Shelver, H. Wu ...

author keywords: flunixin; PBPK models; withdrawal intervals; route of administration; cattle (Bos taurus)
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Drug Residues; Liver / chemistry; Liver / metabolism; Milk / chemistry; Models, Biological; Sensitivity and Specificity; Software; Uncertainty
TL;DR: A physiologically based pharmacokinetic (PBPK) model was developed to predict plasma, liver and milk concentrations of flunixin in cattle following intravenous, intramuscular or subcutaneous administration for use as a tool to determine factors that may affect the withdrawal time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Fluid Therapy in Calves

VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 30(2), 409-+.

By: G. Smith n & J. Berchtold*

author keywords: Fluid therapy; Calves; Diarrhea; Strong ion acidosis
MeSH headings : Animals; Cattle; Cattle Diseases / therapy; Diarrhea / therapy; Diarrhea / veterinary; Fluid Therapy / veterinary
TL;DR: Early and aggressive fluid therapy is critical in correcting the metabolic complications associated with calf diarrhea, but careful consideration should be given to the type of oral electrolyte used. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 book

Fluid and Electrolyte Therapy

In Veterinary Clinics of North America: Food Animal Practice (Vol. 30, pp. 295–486). Elsevier Publishing.

Geof Smith

Ed(s): G. Smith & A. Roussel

Source: NC State University Libraries
Added: February 12, 2021

2014 article

Fluid and Electrolyte Therapy Preface

Roussel, A. J., & Smith, G. W. (2014, July). VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, Vol. 30, pp. IX-X.

By: A. Roussel* & G. Smith n

MeSH headings : Animals; Animals, Newborn; Electrolytes / administration & dosage; Fluid Therapy / methods; Fluid Therapy / veterinary; Ruminants; Water-Electrolyte Imbalance / therapy; Water-Electrolyte Imbalance / veterinary
TL;DR: This issue of the Veterinary Clinics of North America: Food Animal Practice was written by ruminant clinicians for the practicing veterinarian to provide veterinarians with practical information on fluid and electrolyte therapy that can be easily incorporated into all types of practices. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Implantation of an ultrafiltration device in the ileum and spiral colon of steers to continuously collect intestinal fluid

Research in Veterinary Science, 97(3), 611–615.

By: C. Warren, T. Prange, N. Campbell, M. Gerard, L. Martin, M. Jacob*, G. Smith*, M. Papich*, D. Foster*

author keywords: Bovine; Gastrointestinal fluid; Surgery; Ultrafiltration
MeSH headings : Animals; Body Fluids; Cattle; Colon / surgery; Ileum / surgery; Intestinal Secretions; Specimen Handling / methods; Specimen Handling / veterinary; Ultrafiltration / instrumentation
TL;DR: Use of ultrafiltration probes is a novel, consistent and humane method to repeatedly sample the gastrointestinal contents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, ORCID
Added: March 2, 2019

2014 journal article

Passive Immunity Stimulated by Vaccination of Dry Cows with a Salmonella Bacterial Extract

Journal of Veterinary Internal Medicine, 28(5), 1602–1605.

By: G. Smith n, M. Alley n, D. Foster n, F. Smith* & B. Wileman

author keywords: Calves; Colostrum; IgG; Salmonella Newport; SRP
MeSH headings : Animals; Animals, Newborn / immunology; Cattle; Cattle Diseases / immunology; Cattle Diseases / microbiology; Cattle Diseases / prevention & control; Colostrum / immunology; Female; Immunity, Maternally-Acquired / immunology; Immunization, Passive / methods; Immunization, Passive / veterinary; Pregnancy; Salmonella / immunology; Salmonella Infections, Animal / immunology; Salmonella Infections, Animal / prevention & control; Salmonella Vaccines / immunology; Salmonella Vaccines / therapeutic use; Vaccination / methods; Vaccination / veterinary
TL;DR: The results indicate that the use of a commercially available Salmonella vaccine can stimulate antibodies that are passed on to the calf via colostral transfer and further studies need to be done to determine whether these antibodies will offer protection againstSalmonella challenge. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018

2014 chapter

Residue Avoidance in Dairy Cattle Production Systems

In Strategies for Reducing Drug and Chemical Residues in Food Animals (pp. 137–159).

By: G. Smith n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 19, 2019

2013 journal article

Effect of experimental feed additives on aflatoxin in milk of dairy cows fed aflatoxin-contaminated diets

JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 97(4), 694–700.

By: L. Kissell n, S. Davidson*, B. Hopkins*, G. Smith n & L. Whitlow*

author keywords: aflatoxin; milk; binder; feed additive
MeSH headings : Aflatoxin M1 / chemistry; Aflatoxin M1 / metabolism; Animal Feed / analysis; Animals; Bentonite / chemistry; Cattle / metabolism; Diet / veterinary; Dietary Supplements / analysis; Female; Food Contamination / analysis; Milk / chemistry; Milk / metabolism; Oligosaccharides / chemistry
TL;DR: The addition of AB-20(®) to the diet of cattle appears to be effective for significantly reducing AFM1 concentrations in the milk of cows fed an aflatoxin-contaminated diet. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Extralabel Use of Anesthetic and Analgesic Compounds in Cattle

VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 29(1), 29-+.

By: G. Smith n

author keywords: Anesthesia; Analgesia; Pain management; Residues; Pharmacology; Withdrawal
MeSH headings : Analgesia / methods; Analgesia / veterinary; Analgesics / pharmacokinetics; Analgesics / therapeutic use; Anesthesia / methods; Anesthesia / veterinary; Anesthetics / pharmacokinetics; Anesthetics / therapeutic use; Animals; Cattle; Cattle Diseases / drug therapy; Cattle Diseases / prevention & control; Drug Residues / analysis; Meat / analysis; Milk / chemistry; Off-Label Use / veterinary; Pain / drug therapy; Pain / prevention & control; Pain / veterinary
TL;DR: The pharmacokinetics of the main drugs used for sedation, anesthesia, or analgesia in cattle, including information on meat and milk withdrawal where possible are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Occurrence of flunixin residues in bovine milk samples from the USA

Food Additives & Contaminants: Part A, 30(9), 1513–1516.

By: L. Kissell n, R. Baynes n, J. Riviere* & G. Smith n

author keywords: flunixin; milk residues; UPLC-MS; CHARM((R)); milk; food safety
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Cattle; Chromatography, High Pressure Liquid; Clonixin / analogs & derivatives; Clonixin / analysis; Clonixin / metabolism; Dairying / legislation & jurisprudence; Drug Residues / analysis; Enzyme-Linked Immunosorbent Assay; Food Contamination / legislation & jurisprudence; Food Handling; Food Inspection / legislation & jurisprudence; Guideline Adherence; Legislation, Food; Milk / chemistry; Milk / standards; Spectrometry, Mass, Electrospray Ionization; Transportation; United States; United States Department of Agriculture; United States Food and Drug Administration
TL;DR: The results of this study indicate that flunixin residues in milk are possible, and regulatory agencies should be aware that such residues can occur, and should consider incorporating or expanding flunxin screening tests as part of routine drug monitoring in milk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Challenges associated with the demonstration of bioequivalence of intramammary products in ruminants

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35, 65–79.

By: C. Lainesse*, R. Gehring*, K. Pasloske, G. Smith n, S. Soback*, S. Wagner*, T. Whittem*

MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / therapeutic use; Dosage Forms; Drug Administration Routes; Female; Hydrogen-Ion Concentration; Lactation; Mammary Glands, Animal; Mastitis / drug therapy; Models, Biological; Research Design / standards; Ruminants; Therapeutic Equivalency; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: This article explores the numerous challenges encountered when the goal is to demonstrate bioequivalence (BE) between test and reference intramammary (IMM) products in ruminants and discusses the implications of clinically significant formulation differences in the demonstration of BE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Effect of orally administered electrolyte solution formulation on abomasal luminal pH and emptying rate in dairy calves

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 241(8), 1075–1082.

By: G. Smith*, A. Ahmed & P. Constable

MeSH headings : Abomasum / chemistry; Abomasum / physiology; Administration, Oral; Animals; Cattle / physiology; Cross-Over Studies; Dairying; Electrolytes / pharmacology; Gastrointestinal Motility / drug effects; Hydrogen-Ion Concentration; Male
TL;DR: Because persistently high abomasal luminal pH may facilitate growth of enteropathogenic bacteria, administration of OAEs containing a high bicarbonate concentration (> 70mM) is not recommended for calves with diarrhea. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Evaluation of a Serpens species bacterin for treatment of digital dermatitis in dairy cattle

Research in Veterinary Science, 93(3), 1258–1260.

By: A. Fidler n, M. Alley & G. Smith*

author keywords: Digital dermatitis; Lameness; Vaccination
MeSH headings : Animals; Antibodies, Bacterial / blood; Bacterial Vaccines / immunology; Cattle; Cattle Diseases / prevention & control; Dermatitis / prevention & control; Dermatitis / veterinary; Double-Blind Method; Female; Foot Diseases / prevention & control; Foot Diseases / veterinary; Pseudomonadaceae / immunology
TL;DR: The results of this study indicate a lack of any clinical efficacy associated with vaccination in this herd, although inoculation with the bacterin did stimulate a measurable antibody response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2012 chapter

Fumonisins

In Veterinary Toxicology (pp. 1205–1219).

By: G. Smith*

Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2012 journal article

Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(10), 1634–1640.

By: J. Romanet*, G. Smith*, T. Leavens*, R. Baynes*, S. Wetzlich, J. Riviere*, L. Tell

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / blood; Disaccharides / pharmacokinetics; Female; Goats / blood; Goats / metabolism; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Injections, Subcutaneous / veterinary; Male; Tandem Mass Spectrometry / veterinary; Time Factors; Tissue Distribution
TL;DR: The tissue depletion profile of tulathromycin was determined and an appropriate slaughter withdrawal interval in meat goats after multiple SC injections of the drug was determined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle

Journal of Dairy Science, 95(12), 7151–7157.

By: L. Kissell n, G. Smith n, T. Leavens n, R. Baynes n, H. Wu n & J. Riviere n

author keywords: flunixin; residue; pharmacology
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / analysis; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / analysis; Clonixin / blood; Clonixin / pharmacokinetics; Drug Residues / analysis; Female; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Injections, Subcutaneous / veterinary; Milk / chemistry
TL;DR: Cattle that received FLU by the approved (intravenous) route consistently eliminated the drug before the approved withdrawal times; however, residues can persist beyond these approved times following intramuscular or subcutaneous administration. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2012 journal article

Short communication: Evaluation of serum immunoglobulin G concentrations using an automated turbidimetric immunoassay in dairy calves

JOURNAL OF DAIRY SCIENCE, 95(8), 4596–4599.

By: M. Alley n, D. Haines* & G. Smith n

author keywords: failure of passive transfer; immunoglobulin G measurement; immunoassay; colostrum
MeSH headings : Animals; Animals, Newborn; Cattle / immunology; Colostrum / immunology; Female; Immunization, Passive / veterinary; Immunoassay / instrumentation; Immunoassay / standards; Immunoassay / veterinary; Immunoglobulin G / blood; Reproducibility of Results
TL;DR: The immunoassay technique using the portable analyzer represents a reliable method that can be run within 15 min and provide an accurate serum IgG level and could be easily implemented on a dairy farm to help monitor transfer of passive immunity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 chapter

Slaframine

In Veterinary Toxicology (pp. 1227–1230).

By: G. Smith*

Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2011 journal article

Congenital peritoneopericardial diaphragmatic hernia in an alpaca

Australian Veterinary Journal, 89(1-2), 51–54.

By: D. Foster n, S. Chinnadurai n, J. Nutt n, A. Pandiri n, K. Linder n, M. Alley n, G. Smith n

author keywords: abdominal pain; alpacas; camelids; coeliotomy; diaphragmatic hernia; zoo animals
MeSH headings : Abdominal Pain / etiology; Abdominal Pain / surgery; Abdominal Pain / veterinary; Animals; Animals, Zoo; Camelids, New World; Fatal Outcome; Hernia, Diaphragmatic / surgery; Hernia, Diaphragmatic / veterinary; Hernias, Diaphragmatic, Congenital; Laparotomy / veterinary; Male; Postoperative Complications / veterinary
TL;DR: The alpaca died soon after surgery from post-surgical complications and a peritoneopericardial diaphragmatic hernia that was not diagnosed until necropsy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2011 chapter

Diarrea neonatal [Neonatal diarrhea]

In M. M. Cruz (Ed.), Clínica, Cirugía y Producción de Becerras y Vaquillas Lecheras [Medicine, Surgery and Production of Dairy Calves and Heifers] (pp. 257–285). Mexico City: 12 Editorial, A.C.

By: G. Smith

Ed(s): M. Cruz

Source: NC State University Libraries
Added: March 5, 2021

2011 journal article

Efficacy of amprolium for the treatment of pathogenic Eimeria species in Boer goat kids

VETERINARY PARASITOLOGY, 178(3-4), 346–349.

By: G. Young n, M. Alley n, D. Foster n & G. Smith n

author keywords: Coccidiosis; Amprolium; Meat goats; Parasites; Anthelmintics
MeSH headings : Amprolium / administration & dosage; Animals; Coccidiosis / drug therapy; Coccidiosis / parasitology; Coccidiosis / veterinary; Coccidiostats / administration & dosage; Eimeria / growth & development; Feces / parasitology; Female; Goat Diseases / drug therapy; Goat Diseases / parasitology; Goats; Male; Parasite Egg Count / veterinary
TL;DR: The results of this trial indicate that amprolium can be an effective treatment for pathogenic Eimeria species in goat kids, however higher and extralabel doses (50mg/kg) should be used. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 chapter

Hipernatremia [Hypernatremia]

In M. M. Cruz (Ed.), Clínica, Cirugía y Producción de Becerras y Vaquillas Lecheras [Medicine, Surgery and Production of Dairy Calves and Heifers] (pp. 236–239). Mexico City: 12 Editorial, A.C.

By: G. Smith

Ed(s): M. Cruz

Source: NC State University Libraries
Added: March 5, 2021

2011 journal article

Infección por Micoplasma [Mycoplasma infection in calves]

Clínica, Cirugía y Producción De Becerras y Vaquillas Lecheras [Medicine, Surgery and Production of Dairy Calves and Heifers], 188–213.

By: G. Smith

Ed(s): M. Cruz

Source: NC State University Libraries
Added: March 5, 2021

2011 journal article

Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats

RESEARCH IN VETERINARY SCIENCE, 90(3), 477–479.

By: G. Young n, G. Smith n, T. Leavens n, S. Wetzlich*, R. Baynes n, S. Mason n, J. Riviere n, L. Tell*

author keywords: Tulathromycin; Goats; Pharmacokinetics; Respiratory disease; Antibiotics
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Goats / blood; Goats / metabolism; Half-Life; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Injections, Subcutaneous / veterinary; Tandem Mass Spectrometry / veterinary
TL;DR: The pharmacokinetics of tulathromycin after a single 2.5 mg/kg SC injection in goats were very similar to what has been previously reported in cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Short communication: Serum immunoglobulin G and total protein concentrations in dairy calves fed a colostrum-replacement product

JOURNAL OF DAIRY SCIENCE, 94(7), 3609–3612.

By: A. Fidler n, M. Alley n & G. Smith n

author keywords: colostrum; immunoglobulin G; passive immunity
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn / blood; Blood Proteins / analysis; Cattle / immunology; Colostrum / immunology; Food, Formulated; Immunization, Passive / methods; Immunization, Passive / veterinary; Immunoglobulin G / blood; Random Allocation
TL;DR: Calves fed bovine colostrum had significantly higher serum IgG and total protein concentration than calves in either group fed the CR product, and calves fed 1 package of this CR product consistently had failure of transfer of passive immunity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 chapter

Timpanismo abomasal en becerras jóvenes [Abomasal bloat in young calves]

In M. M. Cruz (Ed.), Clínica, Cirugía y Producción de Becerras y Vaquillas Lecheras [Medicine, Surgery and Production of Dairy Calves and Heifers] (pp. 231–236).

By: G. Smith

Ed(s): M. Cruz

Source: NC State University Libraries
Added: March 5, 2021

2010 chapter

Actinobacillosis

In C. M. Kahn & S. Line (Eds.), The Merck Veterinary Manual (10th ed., pp. 539–540). Whitehouse Station, N.J.: Merck and Company.

By: G. Smith

Ed(s): C. Kahn & S. Line

Source: NC State University Libraries
Added: March 12, 2021

2010 chapter

Actinomycosis

In C. M. Kahn & S. Line (Eds.), The Merck Veterinary Manual (10th ed., pp. 540–542). Whitehouse, NY: Merck and Company.

By: G. Smith

Ed(s): C. Kahn & S. Line

Source: NC State University Libraries
Added: March 5, 2021

2010 journal article

Efficacy and Pharmacokinetics of Pantoprazole in Alpacas

JOURNAL OF VETERINARY INTERNAL MEDICINE, 24(4), 949–955.

By: G. Smith n, J. Davis n, S. Smith n, M. Gerard n, N. Campbell n & D. Foster n

author keywords: Camelid; Gastrointestinal agents; Pharmacology; Physiology-gastrointestinal tract
MeSH headings : 2-Pyridinylmethylsulfinylbenzimidazoles / pharmacokinetics; 2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use; Animals; Anti-Ulcer Agents / pharmacokinetics; Anti-Ulcer Agents / therapeutic use; Camelids, New World; Hydrogen-Ion Concentration; Pantoprazole; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary
TL;DR: Based on the results of this study, pantoprazole represents a safe and effective drug for increasing 3rd compartment pH in camelids and either IV or SC administration is likely to be an effective treatment for gastric ulcers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 journal article

A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition

RESEARCH IN VETERINARY SCIENCE, 86(2), 293–301.

By: J. Buur n, R. Baynes n, G. Smith n & J. Riviere n

author keywords: Physiologically based pharmacokinetic; model (PBPK); Drug-drug interaction; Plasma protein binding; Sulfamethazine; Flunixin meglumine
MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Blood Proteins / metabolism; Chromatography, High Pressure Liquid; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Drug Interactions; Drug Therapy, Combination; Female; Models, Biological; Pharmacokinetics; Protein Binding; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / blood; Swine / metabolism; Tissue Distribution
TL;DR: A physiologically based pharmacokinetic model was developed that links plasma protein binding interactions to drug disposition for SMZ and FLU in swine and predicted a sustained decrease in total drug and a temporary increase in free drug concentration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 book

Bovine Neonatology

Philadelphia, PA: W.B. Saunders.

Geof Smith

Ed(s): G. Smith

Source: NC State University Libraries
Added: March 12, 2021

2009 journal article

Bovine neonatology preface

Veterinary Clinics of North America. Food Animal Practice, 25(1), XI-.

By: G. Smith

Source: NC State University Libraries
Added: August 6, 2018

2009 chapter

Dosage forms and veterinary feed directives

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (9th ed., pp. 1439–1444). Wiley-Blackwell Publishing.

By: G. Smith

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: March 12, 2021

2009 journal article

Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle

Journal of the American Veterinary Medical Association, 234(2), 245–248.

By: G. Smith*, J. Davis*, R. Baynes*, J. Yeatts*, B. Barlow* & J. Riviere*

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Cattle; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Infusions, Parenteral / veterinary; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Mastitis, Bovine / metabolism; Metabolic Clearance Rate; Milk / chemistry; Prospective Studies; Tylosin / administration & dosage; Tylosin / analogs & derivatives; Tylosin / analysis; Tylosin / pharmacokinetics
TL;DR: Findings indicated that tilmicosin should not be administered by the intramammary route in lactating dairy cows, and milk from all glands of any cows accidentally treated should be discarded for a minimum of 82 days following intramamsary administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2009 chapter

FARAD and Related Drug Regulations

In Food Animal Practice (pp. 468–470).

By: G. Smith*

Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2009 chapter

Guidelines for Antimicrobial Use in Cattle

In Guide to Antimicrobial Use in Animals (pp. 143–160).

By: P. Constable*, S. Pyörälä* & G. Smith n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2009 journal article

Pathophysiology of Diarrhea in Calves

Veterinary Clinics of North America: Food Animal Practice, 25(1), 13–36.

By: D. Foster n & G. Smith n

author keywords: Rotavirus; Cryptosporidium; Enterotoxigenic Escherichia coli; Coronavirus; Torovirus
MeSH headings : Animals; Animals, Newborn; Cattle; Cattle Diseases / microbiology; Cattle Diseases / parasitology; Cattle Diseases / virology; Coronavirus / isolation & purification; Cryptosporidium / isolation & purification; Diagnosis, Differential; Diarrhea / microbiology; Diarrhea / parasitology; Diarrhea / veterinary; Diarrhea / virology; Escherichia coli / isolation & purification; Feces / microbiology; Feces / parasitology; Rotavirus / isolation & purification
TL;DR: Infectious diarrhea in calves is most commonly associated with enterotoxigenic Escherichia coli, Cryptosporidium parvum, rotav virus, coronavirus, or some combination of these pathogens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2009 journal article

Preface

Veterinary Clinics of North America: Food Animal Practice, 25(1), xi-xii.

By: G. Smith n

TL;DR: This issue of Veterinary Clinics of North America: Food Animal Practice focuses on the pathophysiology, clinical signs, diagnosis, treatment, and prevention of the major diseases affecting calf health around the world, using the important principles of evidencebased medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 5, 2021

2009 journal article

Third-compartment cannulation in alpacas using a polyurethane gastrostomy tube

AUSTRALIAN VETERINARY JOURNAL, 87(12), 487–491.

By: G. Smith n, M. Gerard n, N. Campbell n, D. Foster n, S. Smith n & J. Davis n

author keywords: alpacas; camelids; cannulation; nutritional support; third compartment
MeSH headings : Animals; Camelids, New World / surgery; Gastrostomy / instrumentation; Gastrostomy / methods; Gastrostomy / veterinary; Male; Polyurethanes; Prospective Studies; Surgery, Veterinary / instrumentation; Surgery, Veterinary / methods; Treatment Outcome
TL;DR: Surgical placement of polyurethane tubes designed for percutaneous endoscopic gastrostomy is a useful method of cannulating the third compartment in camelids and can be used for nutritional support and fluid therapy in sick camelids that might need long-term care. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 journal article

Treatment of Calf Diarrhea: Oral Fluid Therapy

VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 25(1), 55-+.

By: G. Smith n

author keywords: Calf diarrhea; Acid base; Fluid therapy; Neonatology; Acidosis; Dehydration; Oral electrolyte
MeSH headings : Administration, Oral; Animals; Animals, Newborn; Cattle; Cattle Diseases / mortality; Cattle Diseases / prevention & control; Cattle Diseases / therapy; Diarrhea / mortality; Diarrhea / prevention & control; Diarrhea / therapy; Diarrhea / veterinary; Female; Fluid Therapy / methods; Fluid Therapy / veterinary; Male; Practice Guidelines as Topic; Treatment Outcome
TL;DR: An overview of oral electrolyte therapy of calves is given, including indications, guidelines for administration, and how to choose an electrolyte product are given. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Update on drugs prohibited from extralabel use in food animals

Davis, J. L., Smith, G. W., Baynes, R. E., Tell, L. A., Webb, A. I., & Riviere, J. E. (2009, September 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 235, pp. 528–534.

By: J. Davis n, G. Smith n, R. Baynes n, L. Tell n, A. Webb n & J. Riviere n

MeSH headings : Animals; Animals, Domestic; Food / standards; Legislation, Drug; Legislation, Veterinary; United States; Veterinary Drugs
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

FARAD digest - Extralabel use of nonsteroidal anti-inflammatory drugs in cattle

Journal of the American Veterinary Medical Association, 232(5), 697–701.

By: G. Smith, J. Davis, L. Tell, A. Webb & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Pharmacokinetics of melamine in pigs following intravenous administration

Food and Chemical Toxicology, 46(3), 1196–1200.

By: R. Baynes n, G. Smith n, S. Mason n, E. Barrett n, B. Barlow n & J. Riviere n

MeSH headings : Animals; Chromatography, High Pressure Liquid; Infusions, Intravenous; Kidney / metabolism; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Swine; Triazines / administration & dosage; Triazines / blood; Triazines / pharmacokinetics
TL;DR: The pharmacokinetic parameters for melamine obtained in pigs are comparable to the only mammalian study in rats and suggests that melamine is readily cleared by the kidney and there is unlikely to be significant tissue binding. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2008 journal article

Posterior paresis resulting from a vertebral body fracture in a bull

The Bovine Practitioner, 42(1), 41–44.

By: D. Foster n, G. Smith n, A. Pandiri n & L. Blond n

TL;DR: A 2.5-year-old, mixed-breed rodeo bull was examined with a four-month history of ataxia and weakness in the pelvic limbs, and a compression fracture of the 13th thoracic vertebrae with secondary damage to the spinal cord was diagnosed. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: March 12, 2021

2007 journal article

Fumonisins: Toxicokinetics, mechanism of action and toxicity

Animal Feed Science and Technology, 137(3-4), 299–325.

By: K. Voss*, G. Smith n & W. Haschek*

author keywords: fumonisins; equine leukoencephalomalacia; porcine pulmonary edema; toxicity; mechanism of action; bioavailability
TL;DR: Fumonisins are mycotoxins produced by Fusarium verticillioides and F. proliferatum found predominantly in maize and in maize-based animal feeds that are toxic to the liver in all species and the kidney in a range of laboratory and farm animal species, causing apoptosis followed by mitosis in the affected tissues. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2007 journal article

Lactoferrin supplementation to holstein calves during the preweaning and postweaning phases

JOURNAL OF DAIRY SCIENCE, 90(11), 5276–5281.

By: E. English n, B. Hopkins n, J. Stroud n, S. Davidson n, G. Smith n, C. Brownie n, L. Whitlow n

author keywords: calf; lactoferrin; weaning
MeSH headings : Animal Feed / analysis; Animals; Body Constitution / drug effects; Body Temperature / drug effects; Body Weight / drug effects; Cattle / growth & development; Cattle / immunology; Cattle / metabolism; Cattle / physiology; Diet / veterinary; Dietary Supplements; Eating / drug effects; Female; Haptoglobins / metabolism; Health Status; Housing, Animal; Immunization, Passive / veterinary; Lactoferrin / administration & dosage; Lactoferrin / pharmacology; Least-Squares Analysis; Male; Respiration / drug effects; Weaning
TL;DR: Lactoferrin supplementation had no effect on feed intake, body weight, average daily gain, heart girth, body temperature, fecal scores, respiratory scores, or haptoglobin concentrations in Holstein calves raised in the barn. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Short Communication: Absorption of Protein and Immunoglobulin G in Calves Fed a Colostrum Replacer

Journal of Dairy Science, 90(6), 2905–2908.

By: G. Smith n & D. Foster n

author keywords: passive transfer; calf diarrhea; colostrum; radial immunodiffusion
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn / blood; Animals, Newborn / immunology; Animals, Newborn / metabolism; Blood Proteins / metabolism; Blood Proteins / pharmacokinetics; Cattle / blood; Cattle / immunology; Cattle / metabolism; Colostrum; Dietary Proteins / metabolism; Dietary Proteins / pharmacokinetics; Immunization, Passive / methods; Immunization, Passive / veterinary; Immunoglobulin G / administration & dosage; Immunoglobulin G / blood; Immunoglobulin G / immunology; Immunoglobulin G / metabolism; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Random Allocation
TL;DR: The colostrum replacer product evaluated in this study failed to routinely provide adequate IgG concentrations when fed according to label directions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2007 chapter

Swine

In W. J. Tranquilli, J. C. Thurmon, K. A. Grimm, & W. V. Lumb (Eds.), Lumb and Jones' Veterinary Anesthesia and Analgesia (4th ed., pp. 747–764). Ames, Iowa: Blackwell.

By: J. Thurmon & G. Smith

Ed(s): W. Tranquilli, J. Thurmon, K. Grimm & W. Lumb

Source: NC State University Libraries
Added: March 12, 2021

2006 journal article

An overview of factors affecting the disposition of intramammary preparations used to treat bovine mastitis

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(4), 237–241.

By: R. Gehring* & G. Smith n

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Cattle; Drug Administration Routes; Female; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Mastitis, Bovine / pathology
TL;DR: Current understanding of factors affecting the disposition of drugs following intramammary administration is summarized and areas of incomplete knowledge requiring further research have been identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Efficacy of vaccination and antimicrobial treatment to eliminate chronic intramammary Staphylococcus aureus infections in dairy cattle

Journal of the American Veterinary Medical Association, 228(3), 422–425.

By: G. Smith n, R. Lyman* & K. Anderson*

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacterial Vaccines / administration & dosage; Cattle; Chronic Disease; Clindamycin / administration & dosage; Clindamycin / analogs & derivatives; Clindamycin / therapeutic use; Dairying / methods; Female; Mastitis, Bovine / drug therapy; Mastitis, Bovine / microbiology; Mastitis, Bovine / prevention & control; Staphylococcal Infections / drug therapy; Staphylococcal Infections / microbiology; Staphylococcal Infections / prevention & control; Staphylococcal Infections / veterinary; Staphylococcus aureus / immunology; Treatment Outcome; Vaccination / veterinary
TL;DR: Results indicate that a combination of vaccination and antimicrobial treatment can be successful in eliminating some cases of chronic intramammary S aureus infections in dairy cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2006 journal article

Pharmacokinetics of flunixin meglumine in swine after intravenous dosing

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(5), 437–440.

By: J. Buur n, R. Baynes n, G. Smith n & J. Riviere n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / metabolism; Clonixin / pharmacokinetics; Half-Life; Injections, Intravenous; Metabolic Clearance Rate; Protein Binding; Swine
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Serum IgG and total protein concentrations in dairy calves fed two colostrum replacement products

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 229(8), 1282–1285.

By: D. Foster n, G. Smith*, T. Sanner & G. Busso*

MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn / blood; Blood Proteins / analysis; Cattle / immunology; Colostrum / immunology; Food, Formulated; Immunization, Passive / methods; Immunization, Passive / veterinary; Immunoglobulin G / blood; Male; Prospective Studies; Random Allocation
TL;DR: Results indicated that product B could be considered as an alternative to colostrum in dairy calves, but product A failed to routinely provide adequate serum IgG concentrations when fed according to label directions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 journal article

Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(7), 2344–2351.

By: J. Buur n, R. Baynes n, G. Smith n & J. Riviere n

MeSH headings : Animals; Animals, Domestic / metabolism; Drug Residues / pharmacokinetics; Female; Legislation, Drug; Legislation, Veterinary; Meat; Models, Statistical; Monte Carlo Method; Predictive Value of Tests; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Swine / metabolism; Time Factors; Tissue Distribution; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: Probabilistic modeling techniques incorporated into a physiologically based pharmacokinetic (PBPK) model were used to predict the amounts of sulfamethazine residues in edible tissues in swine to calculate the withdrawal time by using the tolerance limit algorithm designed by FDA. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Effects of Exogenous Sphinganine, Sphingosine, and Sphingosine-1-Phosphate on Relaxation and Contraction of Porcine Thoracic Aortic and Pulmonary Arterial Rings

Toxicological Sciences, 86(1), 194–199.

By: S. Hsiao*, P. Constable, G. Smith* & W. Haschek

author keywords: fumonisin mycotoxicosis; sphinganine; sphingosine; sphingosine-1-phosphate; aortic and pulmonary arterial rings; pigs
MeSH headings : Animals; Aorta, Thoracic / drug effects; Aorta, Thoracic / physiology; Dose-Response Relationship, Drug; In Vitro Techniques; Lysophospholipids / pharmacology; Muscle Contraction / drug effects; Muscle Relaxation / drug effects; Muscle, Smooth, Vascular / drug effects; Muscle, Smooth, Vascular / physiology; Phenylephrine / pharmacology; Potassium Chloride / pharmacology; Pulmonary Artery / drug effects; Pulmonary Artery / physiology; Sphingosine / analogs & derivatives; Sphingosine / pharmacology; Swine
TL;DR: The results suggested that the systemic hypotension caused by fumonisin is mediated by increases in serum sphinganine and sphingosine concentrations, and the pulmonary hypertension is mediated, in part, by increased sphingoine-1-phosphate concentrations. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 1, 2020

2005 journal article

Effects of Intravenous Hyperosmotic Sodium Bicarbonate on Arterial and Cerebrospinal Fluid Acid-Base Status and Cardiovascular Function in Calves with Experimentally Induced Respiratory and Strong Ion Acidosis

Journal of Veterinary Internal Medicine, 19(2), 240–251.

By: J. Berchtold*, P. Constable*, G. Smith*, S. Mathur*, D. Morin* & W. Tranquilli*

TL;DR: Compared to untreated control calves, HSB-treated calves had higher cardiac index and contractility and a faster rate of left ventricular relaxation for 1 hour after treatment, indicating that HSB administration improved myocardial systolic function. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 1, 2020

2005 journal article

Extralabel intramammary use of drugs in dairy cattle

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 226(12), 1994–1996.

By: G. Smith n, R. Gehring*, A. Craigmill, A. Webb & J. Riviere*

TL;DR: It is extremely important for vetinarians to maintain good records and follow extended withdrawal intervals when using intramam-mary administration of drugs in an extralabel manner to ensure food safety andavoid residue violations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Pharmacokinetics of oral omeprazole in llamas

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(6), 539–543.

By: K. Poulsen, G. Smith*, J. Davis n & M. Papich n

MeSH headings : Administration, Oral; Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / blood; Anti-Ulcer Agents / pharmacokinetics; Area Under Curve; Camelids, New World / metabolism; Female; Omeprazole / administration & dosage; Omeprazole / blood; Omeprazole / pharmacokinetics
TL;DR: Oral omeprazole produced plasma drug concentrations which are not likely to be associated with clinical efficacy in camelids, and due to low absorption the oral dose was increased to 8 and 12 mg/kg and studies were repeated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Supportive therapy of the toxic cow

VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 21(3), 595-+.

By: G. Smith n

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Inflammatory Agents / therapeutic use; Cattle; Cattle Diseases / drug therapy; Cattle Diseases / pathology; Cattle Diseases / therapy; Combined Modality Therapy / veterinary; Endotoxemia / pathology; Endotoxemia / therapy; Endotoxemia / veterinary; Fluid Therapy / veterinary; Sepsis / pathology; Sepsis / therapy; Sepsis / veterinary
TL;DR: A brief discussion of the physiologic consequences of endotoxemia is warranted to gain a better understanding of and appreciation for the importance of aggressive therapy when treating the ‘‘toxic’’ cow. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Abdominal fat necrosis in a pygmy goat associated with fescue toxicosis

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 16(4), 356–359.

By: G. Smith*, D. Rotstein* & C. Brownie n

MeSH headings : Adipose Tissue / pathology; Animals; Ascomycota / pathogenicity; Female; Festuca / microbiology; Goat Diseases / etiology; Goat Diseases / pathology; Goats; Necrosis; Plants, Edible; Poisoning / veterinary
TL;DR: Gross necropsy findings revealed multiple firm, dark yellow, nodular masses of fat throughout the abdominal cavity, which compressed several abdominal organs including the rumen, small intestine, spiral colon, and gall bladder. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows

Journal of the American Veterinary Medical Association, 224(11), 1827–1830.

By: G. Smith n, R. Gehring*, J. Riviere*, J. Yeatts* & R. Baynes*

MeSH headings : Animals; Anti-Infective Agents, Local / administration & dosage; Anti-Infective Agents, Local / analysis; Anti-Infective Agents, Local / pharmacokinetics; Cattle; Cephalosporins / administration & dosage; Cephalosporins / analysis; Cephalosporins / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Milk / chemistry; Prospective Studies; Reagent Kits, Diagnostic / veterinary
TL;DR: Ceftiofur administered by the intramammary route as an extra-label treatment for mastitis in dairy cows reaches concentrations in milk greater than the tolerance set by the FDA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2004 chapter

Fumonisin

In K. H. Plumlee (Ed.), Clinical Veterinary Toxicology (pp. 250–254). St. Louis: Mosby.

By: G. Smith & P. Constable

Ed(s): K. Plumlee

Source: NC State University Libraries
Added: March 15, 2021

2004 journal article

Kalanchoe species poisoning in pets

Veterinary Medicine, 99(11), 933–936.

By: G. Smith

Source: NC State University Libraries
Added: March 15, 2021

2004 journal article

Neurologic Abnormalities and Cerebrospinal Fluid Changes in Horses Administered Fumonisin B1 Intravenously

Journal of Veterinary Internal Medicine, 18(2), 223.

By: J. Foreman*, P. Constable*, A. Waggoner*, M. Levy, R. Eppley*, G. Smith*, M. Tumbleson*, W. Haschek*

author keywords: cerebrospinal fluid; equine leukoencephalomalacia; Fusarium; moldy corn poisoning; mycotoxin
TL;DR: It was concluded that FB1-induced neurologic and CSF changes in a dose-dependent manner, with a no-observable-limit of 0.01 mg FB1/kg IV q24h for 28 days, were consistent with vasogenic cerebral edema. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2021

2004 journal article

Reversibility of the reproductive toxicity of gossypol in peripubertal bulls

THERIOGENOLOGY, 61(6), 1171–1179.

By: M. Hassan*, G. Smith n, R. Ott*, D. Faulkner*, L. Firkins*, E. Ehrhart*, D. Schaeffer*

author keywords: gossypol; reproductive toxicity; cottonseed meal
MeSH headings : Animals; Cattle / physiology; Gossypol / administration & dosage; Gossypol / toxicity; Male; Orchiectomy; Reproduction / drug effects; Scrotum / anatomy & histology; Scrotum / drug effects; Sperm Motility / drug effects; Spermatogenesis / drug effects; Spermatozoa / abnormalities; Spermatozoa / drug effects
TL;DR: Gossypol (8 mg/kg per day for 56 days) increased sperm abnormalities but the effects were reversible, suggesting testicular degeneration and the deleterious effects on the morphological characteristics of spermatozoa were reversible. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

The effects of oral magnesium hydroxide administration on rumen fluid in cattle

Journal of Veterinary Internal Medicine, 18(1), 109–112.

By: G. Smith n & M. Correa n

TL;DR: It is indicated that magnesium hydroxide has a potent alkalinizing effect on rumen pH and significantly decreases rumen microbial activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2003 journal article

Fumonisin-induced blockade of ceramide synthase in sphingolipid biosynthetic pathway alters aortic input impedance spectrum of pigs

American Journal of Physiology-Heart and Circulatory Physiology, 284(6), H2034–H2044.

By: P. Constable*, G. Smith*, G. Rottinghaus*, M. Tumbleson* & W. Haschek

author keywords: afterload; sphingosine; sphinganine; tumor necrosis factor-alpha
MeSH headings : Acyltransferases / antagonists & inhibitors; Adrenergic alpha-Agonists / pharmacology; Adrenergic beta-Agonists / pharmacology; Animals; Aorta / drug effects; Aorta / physiology; Blood Gas Analysis; Calcium / pharmacology; Calibration; Electric Impedance; Enzyme Inhibitors / pharmacology; Fumonisins / pharmacology; Heart / drug effects; Heart / physiology; Isoproterenol / pharmacology; Muscle, Smooth, Vascular / drug effects; Nitroprusside / pharmacology; Phenylephrine / pharmacology; Receptors, Adrenergic, beta-2 / drug effects; Receptors, Adrenergic, beta-2 / physiology; Signal Transduction / drug effects; Sphingolipids / biosynthesis; Sphingosine N-Acyltransferase; Swine; Vascular Resistance / physiology; Vasodilation / drug effects; Vasodilator Agents / pharmacology
Sources: Crossref, NC State University Libraries
Added: September 1, 2020

2002 journal article

Atypical Parapoxvirus Infection in Sheep

Journal of Veterinary Internal Medicine, 16(3), 287–292.

By: G. Smith*, G. Scherba*, P. Constable*, V. Hsiao*, M. Behr* & D. Morin*

author keywords: contagious ecthyma; dermatology; orf; ovine; warts
Sources: Crossref, NC State University Libraries
Added: September 1, 2020

2002 journal article

Cardiovascular changes associated with intravenous administration of fumonisin B1 in horses

American Journal of Veterinary Research, 63(4), 538–545.

By: G. Smith*, P. Constable, J. Foreman, R. Eppley, A. Waggoner, M. Tumbleson, W. Haschek

MeSH headings : Animals; Blood Gas Analysis / veterinary; Blood Pressure / drug effects; Carboxylic Acids / toxicity; Cardiac Output / drug effects; Cardiovascular Diseases / blood; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / physiopathology; Cardiovascular Diseases / veterinary; Encephalomalacia / chemically induced; Encephalomalacia / physiopathology; Enzyme Inhibitors / toxicity; Fumonisins; Heart Rate / drug effects; Horse Diseases / blood; Horse Diseases / chemically induced; Horse Diseases / physiopathology; Horses; Injections, Intravenous / veterinary; Mycotoxins / toxicity; Myocardium / metabolism; Random Allocation; Sphingolipids / blood; Troponin I / blood
TL;DR: An association was detected among fumonisin-induced neurologic disease, increased serum and myocardial sphinganine and sphingosine concentrations, and decreased cardiovascular function in horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 13, 2019

2002 journal article

Suspected pokeweed toxicity in a boer goat

Veterinary and Human Toxicology, 44(6), 351–353.

By: G. Smith & P. Constable

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Ability of Hematologic and Serum Biochemical Variables to Differentiate Gram-Negative and Gram-Positive Mastitis in Dairy Cows

Journal of Veterinary Internal Medicine, 15(4), 394–400.

By: G. Smith*, P. Constable & D. Morin

author keywords: bovine; coliform; neutrophil
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 1, 2020

2001 journal article

Ability of hematologic and serum biochemical variables to differentiate gram-negative and gram-positive mastitis in dairy cows.

Journal of Veterinary Internal Medicine.

Geof Smith

TL;DR: Routine hematologic analysis is useful for predicting pathogen type in dairy cows with clinical mastitis, thereby facilitating treatment decisions, and values for sensitivity and specificity were higher than those previously reported for clinical tests differentiating mastitis episodes caused by gram-negative bacteria from those caused by Gram-positive bacteria. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 13, 2019

2001 journal article

Fumonisin B1 Increases Serum Sphinganine Concentration but Does Not Alter Serum Sphingosine Concentration or Induce Cardiovascular Changes in Milk-Fed Calves

Toxicological Sciences, 60(2), 379–384.

By: S. Mathur*, P. Constable, R. Eppley*, M. Tumbleson, G. Smith*, W. Tranquilli*, D. Morin*, W. Haschek

author keywords: fumonisin; sphingosine; sphinganine; sphingolipid; cardiovascular toxicity; metabolic acidosis
MeSH headings : Acidosis, Respiratory / chemically induced; Animals; Animals, Suckling / blood; Animals, Suckling / physiology; Carboxylic Acids / administration & dosage; Carboxylic Acids / toxicity; Cattle; Fumonisins; Heart Ventricles / drug effects; Heart Ventricles / metabolism; Hematologic Tests; Hemodynamics / drug effects; Hemodynamics / physiology; Injections, Intravenous; Male; Milk; Mycotoxins / administration & dosage; Mycotoxins / toxicity; Myocardium / metabolism; Sphingosine / analogs & derivatives; Sphingosine / blood
TL;DR: It is concluded that calves are more resistant to fumonisin B(1) cardiovascular toxicity than pigs. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 13, 2019

2001 journal article

Fumonisin toxicosis in swine: an overview of porcine pulmonary edema and current perspectives.

Environmental Health Perspectives, 109(suppl 2), 251–257.

By: W. Haschek*, L. Gumprecht*, G. Smith*, M. Tumbleson* & P. Constable*

author keywords: cardiovascular; fumonisin; immune system; liver; pulmonary edema; sphinganine; sphingosine; swine
MeSH headings : Animals; Carboxylic Acids / adverse effects; Carboxylic Acids / immunology; Carboxylic Acids / metabolism; Carboxylic Acids / pharmacokinetics; Fumonisins; Immunity / drug effects; Liver / pathology; Mycotoxins / adverse effects; Mycotoxins / immunology; Mycotoxins / metabolism; Mycotoxins / pharmacokinetics; Myocardium / pathology; Pulmonary Edema / chemically induced; Pulmonary Edema / pathology; Pulmonary Edema / veterinary; Sphingolipids / antagonists & inhibitors; Sphingolipids / biosynthesis; Swine Diseases / chemically induced; Swine Diseases / pathology
TL;DR: Fumonisin-induced pulmonary edema in swine appears to result from acute left-sided heart failure mediated by altered sphingolipid biosynthesis, similar to other species after exposure to fumonisins. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 13, 2019

2001 journal article

Species and organ specificity of fumonisin-induced endothelial alterations: Potential role in porcine pulmonary edema

Toxicology, 160(1-3), 71–79.

By: L. Gumprecht*, G. Smith*, P. Constable* & W. Haschek*

author keywords: endothelial cells; Fusarium verticillioides; fumonisin B-1; fumonisins; heart; kidney; liver; lung; pig; ultrastructure
MeSH headings : Animals; Capillaries / drug effects; Capillaries / ultrastructure; Carboxylic Acids / toxicity; Coronary Vessels / drug effects; Coronary Vessels / ultrastructure; Endothelium, Vascular / drug effects; Endothelium, Vascular / ultrastructure; Fumonisins; Kidney / blood supply; Kidney / drug effects; Kidney / ultrastructure; Liver / blood supply; Liver / drug effects; Liver / ultrastructure; Male; Microscopy, Electron; Mycotoxins / toxicity; Myocardium / pathology; Organ Specificity; Pulmonary Alveoli / blood supply; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / ultrastructure; Pulmonary Edema / chemically induced; Pulmonary Edema / pathology; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Swine
Sources: ORCID, Crossref, NC State University Libraries
Added: November 13, 2019

2000 journal article

Genome size of Eperythrozoon suis and hybridization with 16S rRNA gene

Canadian Journal of Microbiology, 46(11), 1082–1086.

By: J. Messick*, G. Smith*, L. Berent* & S. Cooper

MeSH headings : Genes, Bacterial / genetics; Genome, Bacterial; Mycoplasma / genetics; Nucleic Acid Hybridization; RNA, Ribosomal, 16S / genetics; Restriction Mapping
Sources: ORCID, Crossref, NC State University Libraries
Added: November 13, 2019

2000 journal article

Ingestion of Fumonisin B1-Containing Culture Material Decreases Cardiac Contractility and Mechanical Efficiency in Swine

Toxicology and Applied Pharmacology, 162(3), 151–160.

By: P. Constable*, G. Smith*, G. Rottinghaus* & W. Haschek*

author keywords: end-systolic elastance; stroke work; pressure-volume area; mechanical energetics
MeSH headings : Adrenergic beta-Antagonists / pharmacology; Animal Feed; Animals; Carboxylic Acids / administration & dosage; Carboxylic Acids / toxicity; Cardiotonic Agents / pharmacology; Electrocardiography / drug effects; Fumonisins; Hemodynamics / drug effects; Isoproterenol / pharmacology; Male; Myocardial Contraction / drug effects; Nitroprusside / pharmacology; Propanolamines / pharmacology; Swine; Vasodilator Agents / pharmacology; Ventricular Function, Left / drug effects; Ventricular Pressure / drug effects
TL;DR: In pigs, short-term ingestion of fumonisin B1-containing culture material produces negative inotropic and chronotropic effects and decreases mechanical efficiency of the left ventricle, which is consistent with fumonianin-induced, sphingosine-mediated l-type Ca(2+) channel blockade. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 13, 2019

2000 journal article

Purified Fumonisin B1 Decreases Cardiovascular Function but Does Not Alter Pulmonary Capillary Permeability in Swine

Toxicological Sciences, 56(1), 240–249.

By: G. Smith*

author keywords: fumonisin; cardiovascular; heart failure; pulmonary edema; swine
MeSH headings : Animals; Apoptosis / drug effects; Blood Chemical Analysis; Bronchoalveolar Lavage; Capillary Permeability / drug effects; Carboxylic Acids / pharmacology; Cell Division; Fumonisins; Heart Ventricles / metabolism; Hemodynamics / drug effects; Injections, Intravenous; Liver / drug effects; Liver / pathology; Lung / drug effects; Lung / pathology; Male; Mycotoxins / pharmacology; Organ Size / drug effects; Pulmonary Alveoli / blood supply; Pulmonary Edema / chemically induced; Pulmonary Edema / pathology; Sphingosine / analogs & derivatives; Sphingosine / metabolism; Swine; Ventricular Function, Left / drug effects
TL;DR: The results indicate that cardiovascular function is altered by fumonisin B(1), and that fumoniain-induced pulmonary edema is caused by left-sided heart failure and not by altered endothelial permeability. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 13, 2019

1999 journal article

Ozone in dairy chilling water systems: effect on metal materials

International Journal of Dairy Technology, 52(4), 126–128.

By: A. Greene*, G. Smith* & C. Knight*

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 13, 2019

1999 journal article

Sequence of cardiovascular changes leading to pulmonary edema in swine fed culture material containing fumonisin

American Journal of Veterinary Research, 60(10), 1292–1300.

By: G. Smith, P. Constable, M. Tumbleson, G. Rottinghaus & W. Haschek

Source: NC State University Libraries
Added: March 15, 2021

1999 journal article

Sequence of cardiovascular changes leading to pulmonary edema in swine fed culture material containing fumonisin.

American Journal of Veterinary Research.

Geof Smith

Source: ORCID
Added: November 13, 2019

1996 journal article

Cardiovascular Effects of Fumonisins in Swine

Fundamental and Applied Toxicology.

Geof Smith

MeSH headings : Animals; Electrocardiography / drug effects; Fusarium; Heart / drug effects; Hemodynamics / drug effects; Male; Mycotoxins / toxicity; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 13, 2019

1996 journal article

Cardiovascular Effects of Fumonisins in Swine

Toxicological Sciences, 31(2), 169–172.

By: G. Smith*, P. Constable, C. Bacon, F. Meredith & W. Haschek

TL;DR: Pulmonary hypertension caused by hypoxic vasoconstriction may be associated with the pulmonary edema observed in fumonisin toxicity, suggests this study suggests. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 1, 2020

1996 journal article

Cardiovascular Responses to Short-Term Fumonisin Exposure in Swine

Toxicological Sciences, 33(1), 140–148.

By: G. Smith*, P. Constable* & W. Haschek*

TL;DR: It is suggested that fumonisin increases oxygen consumption and is a negative inotropic and chronotropic agent in pigs and that the observed cardiovascular effects were mediated in part by a fUMonisin-induced increase in tissue sphingosine concentrations. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 13, 2019

1996 journal article

Effects of fumonisin-containing culture material on pulmonary clearance in swine

American Journal of Veterinary Research, 57(8), 1233–1238.

By: G. Smith, P. Constable, A. Smith, C. Bacon, F. Meredith, G. Wollenberg, W. Haschek

Source: NC State University Libraries
Added: March 15, 2021

1996 journal article

Effects of fumonisin-containing culture material on pulmonary clearance in swine.

American Journal of Veterinary Research.

Geof Smith

Source: ORCID
Added: November 13, 2019

1996 chapter

Effects of fumonisins in swine: implications for biomedical research

In M. E. Tumbleson & L. B. Schook (Eds.), Advances in Swine in Biomedical Research (pp. 99–112). New York: Plenum Press.

By: W. Haschek, L. Gumprecht, G. Smith, H. Parker, V. Beasley & M. Tumbleson

Ed(s): M. Tumbleson & L. Schook

Event: International Symposium on Swine in Biomedical Research at University of Maryland, University College Park, Maryland on October 22-25, 1995

Source: NC State University Libraries
Added: March 15, 2021

review

Health concerns and management of select veterinary drug residues

Baynes, R. E., Dedonder, K., Kissell, L., Mzyk, D., Marmulak, T., Smith, G., … Riviere, J. E. [Review of ]. Food and Chemical Toxicology, 88, 112–122.

By: R. Baynes, K. Dedonder, L. Kissell, D. Mzyk, T. Marmulak, G. Smith, L. Tell, R. Gehring, J. Davis, J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

journal article

Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves

Mzyk, D. A., Bublitz, C. M., Martinez, M. N., Davis, J. L., Baynes, R. E., & Smith, G. W. Journal of Veterinary Pharmacology and Therapeutics, 41, 33–33.

By: D. Mzyk, C. Bublitz, M. Martinez, J. Davis, R. Baynes & G. Smith

Source: NC State University Libraries
Added: August 6, 2018

Employment

Updated: June 13th, 2019 10:26

2002 - present

North Carolina State University Raleigh, North Carolina, US
Professor of Ruminant Medicine Population Health and Pathobiology

Education

Updated: June 13th, 2019 10:29

1998 - 2002

University of Illinois System Urbana, IL, US
PhD Department of Pathobiology

1994 - 1998

University of Illinois System Urbana, IL, US
DVM Veterinary Medicine

1990 - 1994

Clemson University Clemson, SC, US
BS Animal and Dairy Science

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