Works (4)
Updated: July 5th, 2023 15:44
2018 journal article
Skin Permeation of Solutes from Metalworking Fluids to Build Prediction Models and Test A Partition Theory
MOLECULES, 23(12).
author keywords: leave-one-solute-out (LOSO) cross-validation; leave-one-out (LOO) cross-validation; linear free-energy relationship (LFER) model; membrane-coated fiber (MCF) approach; partition coefficient; quantitative structure-activity relationship (QSAR); metalworking fluid
MeSH headings : Algorithms; Metals / metabolism; Models, Theoretical; Permeability; Reproducibility of Results; Skin Physiological Phenomena
TL;DR:
Using the membrane-coated fiber as a solid phase membrane extraction (SPME) approach to simulate skin permeation, partition coefficients for 37 solutes under 90 treatment combinations that could broadly represent formulations that could be associated with occupational skin exposure are obtained.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019
2016 journal article
Effects of Electrically Activated Silver-Titanium Implant System Design Parameters on Time-Kill Curves Against Staphylococcus aureus
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 36(3), 325–333.
Contributors: Z. Tan n, n, P. Orndorff n & R. Shirwaiker n
author keywords: Antimicrobial efficacy; Orthopaedic implants; Ionic silver; Post-operative infections; Design parameters
TL;DR:
The in vitro antimicrobial efficacy of a silver-based prophylactic system for orthopaedic implant applications is characterized and provides a reference of design parameters for future product engineering.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Predicting skin permeability from complex chemical mixtures: incorporation of an expanded QSAR model
SAR and QSAR in Environmental Research, 24(9), 711–731.
author keywords: Abraham's LFER model; adjusted Q(LOO)(2); expanded LFER model; leave-one-solute-out; QSAR
MeSH headings : Complex Mixtures / pharmacokinetics; Permeability; Quantitative Structure-Activity Relationship; Skin / drug effects
TL;DR:
An expanded QSAR model is proposed in which one set of partial slopes is defined for each experimental condition, where conditions are defined according to solvent: water, synthetic oil, semi-synthetic oil, or soluble oil, which improved both the model fit and the predictive power when compared with the simple model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Selection of appropriate training and validation set chemicals for modelling dermal permeability by U-optimal design
SAR and QSAR in Environmental Research, 24(2), 135–156.
author keywords: QSAR model; training set selection; Baynes' Rule; U-optimal design; principal component analysis (PCA); applicability domain (AD)
MeSH headings : Chemistry / methods; Inorganic Chemicals / chemistry; Inorganic Chemicals / pharmacokinetics; Models, Statistical; Organic Chemicals / chemistry; Organic Chemicals / pharmacokinetics; Permeability; Quantitative Structure-Activity Relationship; Skin / drug effects
TL;DR:
This paper describes a comprehensive procedure to select training sets from a large candidate set of 4534 solutes, using the newly proposed ‘Baynes’ rule’, which is a modification of Lipinski's ‘rule of five’ to screen out solutes that were not qualified for the study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
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