Works (125)
Updated: December 19th, 2024 05:02
2024 article
Distribution of Polybrominated Diphenyl Ethers (PBDEs) in Placental Tissues of Maternal and Fetal Origin in Exposed Wistar Rats and Associations with Thyroid Hormone Levels
Gaballah, S., Hormon, B., Nelson, G. S. A. M., Cao, J., Hoffman, K., Patisaul, H. B., & Stapleton, H. M. (2024, November 29). TOXICOLOGICAL SCIENCES, Vol. 11.
author keywords: Placenta; flame retardants; PBDEs; thyroid hormone; rat
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 16, 2024
2024 journal article
Identification of hippocampal area CA2 in hamster and vole brain
JOURNAL OF COMPARATIVE NEUROLOGY, 532(3).
author keywords: aggression; hippocampus; social behavior
open access via doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2024 journal article
Sex-specific effects on elements of the social brain neural network in Wistar rats from perinatal exposure to FireMaster 550 or its components
NEUROTOXICOLOGY, 105, 111–120.
author keywords: Flame retardants; Sex difference; Serotonin; Estrogen receptor alpha; Oxytocin receptor; Neurobehavior; Amygdala; BNST
Sources: Web Of Science, NC State University Libraries
Added: October 8, 2024
2024 journal article
Words Matter: Reflective Science Communication and Tradeoffs in Environmental Health Research
ENVIRONMENTAL HEALTH PERSPECTIVES, 132(10).
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2024
2023 journal article
A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement
ENVIRONMENTAL HEALTH, 21(SUPPL 1).
author keywords: Chemicals; Conflicts of Interest; Environmental Health; Environmental Justice; EPA; Hazard Identification; Health Equity; Risk Assessment; TSCA
MeSH headings : Humans; Environmental Exposure / adverse effects; Environmental Exposure / prevention & control; Environmental Health; Environmental Pollutants / analysis; Public Health; Risk Assessment; Consensus Development Conferences as Topic
TL;DR:
Consensus recommendations for health-protective, scientific approaches to reduce harmful chemical exposures are developed, which can be applied to current US policies governing industrial chemicals and environmental pollutants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023
2023 review
Advancing the science on chemical classes
[Review of ]. ENVIRONMENTAL HEALTH, 21(SUPPL 1).
author keywords: Chemical class; Regulation; Decision-making; Toxic chemicals; Risk assessment; Chemical grouping; Ortho-phthalates
MeSH headings : Humans; Hazardous Substances / toxicity; Risk Assessment / methods
TL;DR:
Evaluation of how classes of chemicals are defined and used identified commonalities and differences based on regulatory frameworks, risk assessments, and business strategies and identified that using a class-based approach could result in a more efficient process to reduce exposures to multiple hazardous chemicals and, ultimately, reduce health risks.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023
2023 journal article
Developmental organophosphate flame retardant exposure disrupts adult hippocampal neurogenesis in Wistar rats
NEUROTOXICOLOGY, 99, 104–114.
author keywords: Neurodevelopment; OPFR; OPE; Flame retardants; Neurotoxicity; Neurotoxicology; Postnatal; Reproductive and developmental toxicology; Hippocampus; Dentate gyrus; Adult hippocampal neurogenesis
TL;DR:
Results indicate that developmental OPFR exposure has significant, sex specific impacts on multiple markers of AHN in the dentate gyrus of rats, and further elucidate the developmental neurotoxic properties of OPFRs and highlight the importance of including sex as a biological variable in neurotoxicology research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023
2023 journal article
Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (<i>Microtus ochrogaster</i>)
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 576.
author keywords: Pregnancy; EDCs; Endocrine disruptors; Neurotoxicology; Developmental toxicology; Organophosphate
TL;DR:
Prairie voles are used, a monogamous and bi-parental rodent, leveraged for decades to decipher the underpinnings of social behaviors, to examine the impact of fetal FR exposure on gene targets in the mid-gestational placenta and fetal brain and provide insights on the mechanisms by which FRs impair neurodevelopment and later in life social behaviors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023
2023 article
Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure
Newell, A. J., Jima, D., Reading, B., & Patisaul, H. B. (2023, July 3). TOXICOLOGICAL SCIENCES, Vol. 7.
author keywords: artificial intelligence; toxicogenomics; neurodevelopment; OPFR; OPE; flame retardants; neurotoxicology; hippocampus; cortex; placenta
TL;DR:
It is shown how machine learning can complement more traditional analytical approaches to identify vulnerable "signature" pathways disrupted by chemical exposures and biomarkers of exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023
2023 journal article
Skeletal effects following developmental flame-retardant exposure are specific to sex and chemical class in the adult Wistar rat
FRONTIERS IN TOXICOLOGY, 5.
author keywords: endocrine disrupting chemicals; flame retardants; sex difference; osteotoxicology; computed tomography; bone
TL;DR:
Although sex specificity was expected due to the sexual dimorphic nature of skeletal physiology, the mechanisms accounting for the male- and female-specific phenotypes remain to be determined and future work aims to clarify these unresolved issues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023
2023 journal article
Uncovering the common factors of chemical exposure and behavior: Evaluating behavioral effects across a testing battery using factor analysis
NEUROTOXICOLOGY, 99, 264–273.
author keywords: EDCs; Endocrine disruptors; Neurodevelopment; Neurotoxicology; Organophosphate; Flame retardants; Vole; Behavior
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023
2022 journal article
Developmental nicotine exposure and masculinization of the rat preoptic area
NEUROTOXICOLOGY, 89, 41–54.
author keywords: Nicotine; Neurodevelopment; Sex differences; DNA methylation; Preoptic area; Toxicology; Sex behavior
MeSH headings : Animals; Electronic Nicotine Delivery Systems; Female; Male; Nicotine / toxicity; Preoptic Area / metabolism; Rats; Sex Characteristics; Sex Differentiation; Testosterone
TL;DR:
In neonates (PND4), nicotine exposure induced trending alterations to methylation-dependent masculinizing gene (MDMG) expression and DNA methylation levels at sexually-dimorphic differentially-methylated regions (DMRs), suggesting that developmental nicotine exposure is capable of triggering masculinization of the rat POA via epigenetic mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022
2022 journal article
Editorial: Women in developmental and reproductive toxicology: 2021
Frontiers in Toxicology, 4.
author keywords: mentor; women's health; gender; fetal; mammary gland; placenta
UN Sustainable Development Goal Categories
5. Gender Equality
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 26, 2023
2022 journal article
Effects of developmental exposure to FireMaster (R) 550 (FM 550) on microglia density, reactivity and morphology in a prosocial animal model
NEUROTOXICOLOGY, 91, 140–154.
author keywords: Prefrontal cortex; Sex difference; Neurodevelopment; Endocrine disrupting chemicals; Flame retardants; Vole
MeSH headings : Animals; Arvicolinae; Female; Humans; Male; Mice; Microglia; Models, Animal; Organophosphates; Polybrominated Biphenyls; Pregnancy; Rats
TL;DR:
Overall, FM 550 exposure resulted in reduced numbers of microglia in most regions examined, with the 1000µg FM 550 exposed males particularly affected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 20, 2022
2022 article
Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters
Witchey, S. K., Doyle, M. G., Fredenburg, J. D., St Armour, G., Horman, B., Odenkirk, M. T., … Patisaul, H. B. (2022, September 8). NEUROENDOCRINOLOGY, Vol. 9.
TL;DR:
This study reveals multiple mechanisms by which the components of a common FR mixture are developmentally neurotoxic and that the OPFRs may be the compounds of greatest concern.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022
2022 journal article
Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles
TOXICS, 10(5).
author keywords: endocrine disruptors; flame retardants; sexual differentiation; pair bond
TL;DR:
Evidence is provided that chemical and social stressors can have unique behavioral effects that differ by sex but may not produce worse outcomes in combination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 13, 2022
2022 journal article
Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat
TOXICOLOGICAL SCIENCES, 191(2), 357–373.
author keywords: neurodevelopment; monoamine; OPFR; OPE; flame retardants; neurotransmitters; neurotoxicity; neurotoxicology; prenatal; reproductive and developmental toxicology; mesocortical dopamine system; tissue clearing light sheet microscopy.
TL;DR:
Results indicate maternal exposure to OPFRs alters the development trajectory of the embryonic dopaminergic system and adds to growing evidence of OPFR developmental neurotoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024
2022 article
Virtual Issue: Neurotoxicology
Sombers, L. A., & Patisaul, H. B. (2022, August 3). ACS CHEMICAL NEUROSCIENCE, Vol. 13, pp. 2238–2239.
Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022
2021 journal article
Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers
ENVIRONMENTAL HEALTH PERSPECTIVES, 129(10).
MeSH headings : Acetylcholinesterase; Child; Environmental Monitoring; Esters; Female; Flame Retardants / analysis; Humans; Organophosphates / urine; Placenta / metabolism; Plasticizers / analysis; Plasticizers / metabolism; Plasticizers / toxicity; Pregnancy
TL;DR:
It is demonstrated that OPEs can alter neurodevelopmental processes by interfering with noncholinergic pathways at environmentally relevant doses and may have implications for the development of cognitive and social skills in children.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 29, 2021
2021 review
Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways
[Review of ]. REPRODUCTION, 162(5), F111–F130.
MeSH headings : Endocrine Disruptors / toxicity; Female; Humans; Male; Neurosecretory Systems; Pregnancy; Puberty; Reproduction; Semen Analysis
TL;DR:
This review focuses on endocrine disrupting compounds (EDCs), both naturally occurring and man-made, and summarizes how they interfere with the neuroendocrine system to adversely impact pregnancy outcomes, semen quality, age at puberty, and other aspects of human reproductive health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 journal article
FireMaster (R) 550 (FM 550) exposure during the perinatal period impacts partner preference behavior and nucleus accumbens core medium spiny neuron electrophysiology in adult male and female prairie voles, Microtus ochrogaster
HORMONES AND BEHAVIOR, 134.
author keywords: Vole; Electrophysiology; Nucleus accumbens; Flame retardants; Endocrine disruptors; Neurodevelopment; Endocrine disrupting chemical
MeSH headings : Animals; Arvicolinae; Electrophysiology; Female; Grassland; Male; Neurons; Nucleus Accumbens; Organophosphates; Pair Bond; Polybrominated Biphenyls; Pregnancy; Social Behavior; Zebrafish
TL;DR:
The hypothesis that developmental exposure to FM 550 impacts attachment behaviors is supported and a novel FM 550 effect on neural electrophysiology is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021
2021 journal article
Neural correlates of mating system diversity: oxytocin and vasopressin receptor distributions in monogamous and non-monogamous Eulemur
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Biological Evolution; Brain / metabolism; Brain Mapping / methods; Evolution, Molecular; Female; Lemuridae / metabolism; Male; Memory; Neurosecretory Systems / metabolism; Oxytocin / metabolism; Pair Bond; Primates; Receptors, Oxytocin / metabolism; Receptors, Vasopressin / metabolism; Reproduction; Sexual Behavior, Animal / physiology; Social Behavior; Species Specificity; Vasopressins / metabolism
TL;DR:
It is found that some binding patterns across Eulemur reminiscent of olfactory-guided rodents, but others congruent with more visually oriented anthropoids, consistent with lemurs occupying an ‘intermediary’ evolutionary niche between haplorhine primates and other mammalian groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 15, 2021
2021 journal article
Neurotoxicity of Ortho-Phthalates: Recommendations for Critical Policy Reforms to Protect Brain Development in Children
AMERICAN JOURNAL OF PUBLIC HEALTH, 111(4), 687–695.
MeSH headings : Animals; Brain / drug effects; Child; Child Development / drug effects; Environmental Exposure / adverse effects; Female; Government Regulation; Humans; Infant; Longitudinal Studies; Male; Phthalic Acids / adverse effects; Phthalic Acids / toxicity; Policy Making; Pregnancy; Prenatal Exposure Delayed Effects; Reproduction / drug effects
TL;DR:
This work proposes critically needed policy reforms to eliminate ortho-phthalates from products that lead to exposure of pregnant women, women of reproductive age, infants, and children, and recommends that a class approach be used in assessing health impacts as has been done with other chemical classes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 24, 2021
2021 journal article
Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture
ENDOCRINOLOGY, 162(8).
Contributors: S. Gillera n, W. Marinello n , K. Cao n, B. Horman n, H. Stapleton * & n
author keywords: Social; anxiety; neurodevelopment; neural; endocrine disruptors; endocrine disrupting chemicals; oxytocin; vasopressin; dopamine
MeSH headings : Animals; Arginine Vasopressin / metabolism; Arvicolinae; Endocrine Disruptors / toxicity; Female; Flame Retardants / toxicity; Male; Neurons / drug effects; Neurons / metabolism; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / drug effects; Sex Factors; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
Results expand on previous work showing evidence of endocrine disruption of OT/AVP pathways, including to subpopulations of PVN AVP neurons that coordinate osmoregulatory functions in the periphery, by testing the hypothesis that FM 550 sex-specifically alters AVP and OT neuronal populations in critical nuclei.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021
2021 journal article
Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Body Weight / drug effects; Body Weight / genetics; Cadmium / toxicity; Female; Fetal Development / drug effects; Fetal Development / genetics; Humans; Maternal Exposure; Metabolomics / methods; Mice; Mice, Inbred C57BL; Neurodevelopmental Disorders / chemically induced; Neurodevelopmental Disorders / genetics; Placenta / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Proteomics / methods; Transcriptome / genetics
TL;DR:
The identification of multiple pathways perturbed in the developing brain provides a basis for future studies determining the mechanistic links between maternal Cd exposure and altered neurodevelopment and behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 30, 2021
2020 journal article
Analysis of neurotransmitters in rat placenta exposed to flame retardants using IR-MALDESI mass spectrometry imaging
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 412(15), 3745–3752.
author keywords: IR-MALDESI; Mass spectrometry imaging; Neurotransmitters; Exposomics
MeSH headings : Animals; Female; Flame Retardants / adverse effects; Infrared Rays; Neurotransmitter Agents / analysis; Optical Imaging / instrumentation; Optical Imaging / methods; Placenta / chemistry; Placenta / diagnostic imaging; Pregnancy; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
Changes in the abundance and spatial distribution of neurotransmitters in rat placenta following chemical exposure could be determined using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2020 journal article
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies
REPRODUCTIVE TOXICOLOGY, 98, 29–60.
Contributors: J. Heindel*, S. Belcher n , J. Flaws *, G. Prins *, S. Ho*, J. Mao *, n , W. Ricke *
author keywords: CLARITY-BPA; Guideline study; Bisphenol A; EDC; Endocrine disruptor; GLP; Systemic effects
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; DNA Methylation; Endocrine Disruptors / toxicity; Female; Gene Expression Regulation, Developmental / drug effects; Heart / drug effects; Heart / growth & development; Male; Mammary Glands, Animal / drug effects; Mammary Glands, Animal / growth & development; Maternal-Fetal Exchange; Ovary / drug effects; Ovary / growth & development; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Prostate / drug effects; Prostate / growth & development; Rats, Sprague-Dawley; Reproducibility of Results; Thyroid Gland / drug effects; Thyroid Gland / growth & development; Urethra / drug effects; Urethra / growth & development
TL;DR:
The goal of this collaboration was to provide a more comprehensive dataset upon which to base safety standards and to determine whether industry-standard tests are as sensitive and predictive as molecular and disease-associated endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 19, 2021
2020 journal article
Developmental Exposure to the Flame Retardant Mixture Firemaster 550 Compromises Adult Bone Integrity in Male but not Female Rats
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(7).
author keywords: obesogen; endocrine disrupting chemicals; sex difference; adipose; trabecular; cortical bone; ppar gamma
MeSH headings : Animals; Bone and Bones / drug effects; Cellular Reprogramming / drug effects; Dust / analysis; Environmental Monitoring / methods; Female; Flame Retardants / adverse effects; Halogenation / drug effects; Lactation / drug effects; Male; Mesenchymal Stem Cells / drug effects; Organophosphates / adverse effects; Polybrominated Biphenyls / adverse effects; Rats; Rats, Wistar
TL;DR:
The fact that the phenotype was observed months after exposure suggests that FM 550 altered some fundamental aspect of mesenchymal stem cell reprogramming, and the severity of the phenotype and the human-relevance of the dose employed, affirm this is an adverse outcome meriting further exploration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 15, 2020
2020 journal article
Effects of Prenatal Exposure to a Mixture of Organophosphhate Flame Ritardants on Placental Gene Expression and Serotonergic Innervaion in the Fetal Rat Brain
TOXICOLOGICAL SCIENCES, 176(1), 203–223.
author keywords: endocrine disruptors; endocrine toxicology; flame retardants; metabolome; neurotoxicity; developmental; neurotoxicology; neurotransmitter; developmental toxicity; prenatal; reproductive and developmental toxicology; developmental/teratology
MeSH headings : Animals; Brain / drug effects; Female; Fetal Development; Fetus; Flame Retardants / toxicity; Gene Expression; Humans; Male; Organophosphates; Organophosphorus Compounds; Placenta / metabolism; Plasticizers; Polybrominated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Serotonin / metabolism
TL;DR:
Findings suggest that OPFRs have the potential to impact the 5-HTergic system in the fetal forebrain by disrupting placental Trp metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 14, 2020
2020 journal article
Interactions of the estrous cycle, novelty, and light on female and male rat open field locomotor and anxiety-related behaviors
PHYSIOLOGY & BEHAVIOR, 228.
author keywords: Estrous cycle; Locomotor and anxiety-related behavior; Open-field; Novelty; Light; Sex differences
MeSH headings : Animals; Anxiety; Behavior, Animal; Estrous Cycle; Estrus; Female; Light; Male; Rats
TL;DR:
The open field test is used to disassociate differences in behavior resulting from each of these factors by testing the hypothesis that locomotor and anxiety-related behaviors differ between estrous cycle phases in female rats and that novelty and light exposure concurrently influence these behaviors in both female and male rats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021
2020 article
Introduction to sex differences in neurotoxic effects
NEUROTOXICOLOGY AND TERATOLOGY, Vol. 83.
MeSH headings : Animals; Environmental Exposure; Female; Humans; Male; Maternal Exposure; Maternal-Fetal Exchange; Neurotoxicity Syndromes / etiology; Neurotoxins / administration & dosage; Neurotoxins / toxicity; Paternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Sex Characteristics; Sexual Maturation; Stress, Physiological
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021
2020 journal article
Temporal and bidirectional influences of estradiol on voluntary wheel running in adult female and male rats
HORMONES AND BEHAVIOR, 120.
author keywords: Estradiol; Sex differences; Voluntary wheel running; Locomotion; Motivation
MeSH headings : Animals; Behavior, Animal / drug effects; Estradiol / analogs & derivatives; Estradiol / pharmacology; Female; Male; Motivation / drug effects; Motor Activity / drug effects; Rats; Rats, Sprague-Dawley; Running / physiology; Sex Characteristics; Time Factors
TL;DR:
Findings indicate that estradiol rapidly, non-rapidly, and bidirectionally modulates wheel running in a sex-responsive manner, and that rapid est radiol action is modulated by non-Rapid Estradiol action.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020
2019 review
Achieving CLARITY on bisphenol A, brain and behaviour
[Review of ]. JOURNAL OF NEUROENDOCRINOLOGY, 32(1).
author keywords: amygdala; anxiety; EDC; endocrine disrupting chemical; hypothalamus; oxytocin
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Brain / drug effects; Endocrine Disruptors / toxicity; Female; Humans; Male; Neurons / drug effects; Phenols / toxicity; Pregnancy; Sex Differentiation / drug effects; United States; United States Food and Drug Administration
TL;DR:
Evidence of altered neuroendocrine development, including age‐ and sex‐specific expression of oestrogen receptor (ER)α and ERβ, and the abrogation of brain and behavioural sexual dimorphisms, supports the conclusion that developmental BPA exposure, even at doses below what regulatory agencies regard as “safe” for humans, contribute to brain and behaviour change.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 17, 2020
2019 journal article
Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
NATURE REVIEWS ENDOCRINOLOGY, 16(1), 45–57.
MeSH headings : Animals; Consensus; Endocrine Disruptors / adverse effects; Environmental Exposure / adverse effects; Environmental Exposure / prevention & control; Environmental Pollutants / adverse effects; Environmental Pollutants / metabolism; Humans; Receptors, Corticotropin / metabolism
TL;DR:
This Expert Consensus Statement reflects on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and uses diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019
2019 journal article
Metabotropic glutamate receptor subtype 5 (mGlu5) is necessary for estradiol mitigation of light-induced anxiety behavior in female rats
Physiology & Behavior, 214, 112770.
author keywords: Estradiol; Metabotropic glutamate receptor 5; Female; Anxiety; Estrogen
MeSH headings : Animals; Anxiety / prevention & control; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Excitatory Amino Acid Antagonists / pharmacology; Female; Light; Locomotion / drug effects; Ovariectomy; Pyridines / pharmacology; Rats; Receptor, Metabotropic Glutamate 5 / metabolism
TL;DR:
Novel findings indicate that mGlu5 activation is necessary for estradiol mitigation of anxiety-related behaviors induced by an acute stressor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 10, 2020
2019 journal article
PBDEs Concentrate in the Fetal Portion of the Placenta: Implications for Thyroid Hormone Dysregulation
ENDOCRINOLOGY, 160(11), 2748–2758.
MeSH headings : Animals; Female; Halogenated Diphenyl Ethers / pharmacokinetics; Humans; Male; Membrane Transport Proteins / metabolism; Placenta / metabolism; Pregnancy; Rats, Wistar; Thyroid Hormones / metabolism
TL;DR:
The placenta is a significant modifier of fetal exposures, and that polybrominated diphenyl ethers are impacting TH regulation in a sex-specific manner during this critical window of development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020
2019 journal article
Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study
NEUROTOXICOLOGY, 74, 139–148.
author keywords: Behavior; Estrogen; Endocrine disruption; Sexual differentiation; Neuroendocrine; Oxytocin
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Brain Chemistry / drug effects; Endocrine Disruptors / toxicity; Ethinyl Estradiol / toxicity; Female; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Oxytocin / biosynthesis; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin / biosynthesis; Septal Nuclei / drug effects; Septal Nuclei / metabolism; Sex Characteristics
TL;DR:
Prenatal exposure to BPA can eliminate sex differences in OTR expression in three hypothalamic regions, and that male O TR expression may be more susceptible, and a sexually dimorphic sub-region of the BNST not previously reported in juvenile rats is identified that is also susceptible to B PA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 21, 2019
2019 journal article
Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats
NeuroToxicology, 75, 136–147.
author keywords: brain; anxiety; endocrine disruptions; sex differences; hyperactivity; neural; sexually dimorphic; neurotoxic; flame retardants; elevated plus maze; neurodevelopment
MeSH headings : Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Flame Retardants / toxicity; Maze Learning / drug effects; Motor Activity / drug effects; Polybrominated Biphenyls / toxicity; Rats; Rats, Wistar / growth & development; Sex Factors
TL;DR:
It is demonstrated that exposure to environmental contaminants, like TBBPA, can have sex-specific effects on behavior highlighting the vulnerability of the developing brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: December 16, 2019
2019 review
The Use and Misuse of Historical Controls in Regulatory Toxicology: Lessons from the CLARITY-BPA Study
[Review of ]. ENDOCRINOLOGY, 161(5).
author keywords: adenocarcinoma; Food and Drug Administration; gavage; lymphocyte infiltration; National Toxicology Program; obesity
MeSH headings : Animals; Benzhydryl Compounds / poisoning; Benzhydryl Compounds / toxicity; Ecotoxicology / methods; Ecotoxicology / standards; Endocrine Disruptors / poisoning; Endocrine Disruptors / toxicity; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Guidelines as Topic; Humans; National Institute of Environmental Health Sciences (U.S.); Phenols / poisoning; Phenols / toxicity; Toxicity Tests / methods; Toxicity Tests / standards; United States; United States Food and Drug Administration
TL;DR:
Using FDA-proposed historical control data, an aspect of "guideline" studies, the use of so-called "historical controls", which are essentially control data borrowed from prior studies to aid in the interpretation of current findings are examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2018 journal article
Animal models of endocrine disruption
Best Practice & Research Clinical Endocrinology & Metabolism, 32(3), 283–297.
author keywords: vole; peromyscus; toxicology; neurosciences; collaborative cross; PFOA
MeSH headings : Animals; Disease Models, Animal; Endocrine Disruptors / toxicity; Endocrine System / drug effects; Endocrine System Diseases / chemically induced; Endocrine System Diseases / pathology; Environmental Exposure / adverse effects; Environmental Illness / chemically induced; Environmental Illness / pathology; Humans; Reproducibility of Results; Reproduction / drug effects; Reproduction / physiology
TL;DR:
Advances in genomics, neuroimaging and other tools are making a wider range of animal models more widely available to EDC researchers, and a greater diversity of species are used to effectively model more subtle but significant outcomes such as changes in pubertal timing, mammary gland development, and social behaviors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2018 journal article
CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems
Basic & Clinical Pharmacology & Toxicology, 10(S3), 14–31.
Contributors: G. Prins *, n , S. Belcher n & L. Vandenberg *
author keywords: Bisphenol A; CLARITY-BPA; endocrine disruptor; endocrine-disrupting chemical; oestrogen
MeSH headings : Animals; Benzhydryl Compounds / toxicity; Congresses as Topic; Disease Models, Animal; Ecotoxicology / methods; Ecotoxicology / standards; Endocrine Disruptors / toxicity; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Female; Fetal Development / drug effects; Guidelines as Topic; Humans; National Institute of Environmental Health Sciences (U.S.) / standards; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / prevention & control; Rats, Sprague-Dawley; Risk Assessment / methods; Risk Assessment / standards; Toxicity Tests / methods; Toxicity Tests / standards; United States; United States Food and Drug Administration / standards
TL;DR:
The findings highlighted herein corroborate a significant body of evidence that documents adverse effects of BPA at doses relevant to human exposures and emphasizes the need for updated risk assessment analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 17, 2019
2018 journal article
EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain
ENDOCRINE CONNECTIONS, 7(2), 305–324.
author keywords: endocrine disruptors; flame retardants; behavior; serotonin; sexually dimorphic; EDC; brain
TL;DR:
It is demonstrated that environmental contaminants, like FM 550, have the potential to impact the developing brain by disrupting normal placental functions.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Environmental Mechanisms of Neurodevelopmental Toxicity
Current Environmental Health Reports, 5(1), 145–157.
author keywords: Neurodevelopment; Neurotoxicity; Xenobiotic; Neuroendocrine; Neuroimmune
MeSH headings : Brain / drug effects; Brain / growth & development; Environmental Exposure / adverse effects; Humans; Immune System / drug effects; Neurodevelopmental Disorders / chemically induced; Neurosecretory Systems / drug effects; Oxidative Stress / drug effects
TL;DR:
Recent findings regarding novel mechanisms of developmental neurotoxicity are reported on and emerging areas of interest include neuroendocrine and immune disruption, as well as indirect toxicity via actions on other organs such as the gut and placenta are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2018 journal article
IR-MALDESI mass spectrometry imaging of underivatized neurotransmitters in brain tissue of rats exposed to tetrabromobisphenol A
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(30), 7979–7986.
author keywords: IR-MALDESI; Neurotransmitters; Mass spectrometry imaging; Exposomics; Orbitrap
MeSH headings : Animals; Brain; Female; Infrared Rays; Neurotransmitter Agents / chemistry; Polybrominated Biphenyls / toxicity; Rats; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
This study serves as a demonstration of a new application of IR-MALDESI, namely that neurotransmitter distributions can be confidently and rapidly imaged without derivatization, and is used for the analysis of neurotransmitters in the brains of rats exposed to TBBPA in gestation and lactation through their mothers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018
2018 journal article
Individual Variation in Social Behaviours of Male Lab-reared Prairie voles (Microtus ochrogaster) is Non-heritable and Weakly Associated with V1aR Density
Scientific Reports, 8(1), 1396.
Contributors: A. Vogel, * , S. Arambula, F. Tiezzi & L. McGraw*
MeSH headings : Animals; Arvicolinae / physiology; Basal Forebrain / metabolism; Female; Male; Mating Preference, Animal; Pair Bond; Receptors, Vasopressin / metabolism; Social Behavior
TL;DR:
Heritability estimates of variation in partner preference were low, yet heritability estimates for V1aR expression were high, indicating that the extensive variation in Partner preference observed within this population is due largely to environmental plasticity.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 17, 2019
2018 article
Introduction to the special issue on endocrine disrupting chemicals and behavior
Barrett, E. S., & Patisaul, H. B. (2018, May). HORMONES AND BEHAVIOR, Vol. 101, pp. 1–2.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Novel unconditioned prosocial behavior in prairie voles (Microtus ochrogaster) as a model for empathy
BMC Research Notes, 11(1).
MeSH headings : Animals; Arginine Vasopressin / genetics; Arginine Vasopressin / metabolism; Arvicolinae / physiology; Arvicolinae / psychology; Behavior, Animal / physiology; Cooperative Behavior; Dopaminergic Neurons / cytology; Dopaminergic Neurons / metabolism; Empathy / physiology; Female; Gene Expression; Humans; Hypothalamus / cytology; Hypothalamus / metabolism; Male; Models, Animal; Oxytocin / genetics; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / cytology; Paraventricular Hypothalamic Nucleus / metabolism; Tyrosine 3-Monooxygenase / genetics; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
The consistency between neuroanatomical mechanisms linked to empathy, and the durations of time spent engaging in empathic contact, support the prediction that the empathy contact in this test is a distinct prosocial behavior, lacking prior behavioral training or the naturally occurring ethological relevance of other prosocial behaviors, and is a measure of empathy.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2018 journal article
Nucleus accumbens core medium spiny neuron electrophysiological properties and partner preference behavior in the adult male prairie vole, Microtus ochrogaster
Journal of Neurophysiology, 119(4), 1576–1588.
author keywords: electrophysiology; medium spiny neuron; nucleus accumbens; rat; vole
MeSH headings : Action Potentials / physiology; Animals; Arvicolinae / physiology; Excitatory Postsynaptic Potentials / physiology; Male; Mating Preference, Animal / physiology; Neurons / physiology; Nucleus Accumbens / physiology; Patch-Clamp Techniques; Social Behavior
TL;DR:
It is found that decreases in miniature excitatory postsynaptic current amplitude and the slope of the evoked action potential firing rate to depolarizing current injection weakly associated with increased preference for the partnered female, suggests that exciteatory synaptic strength and neuronal excitability may be decreased in MSNs in males exhibiting stronger preference for a partnered female.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2018 journal article
The NIEHS TaRGET II Consortium and environmental epigenomics
Nature Biotechnology, 36(3), 225–227.
MeSH headings : Environmental Exposure / adverse effects; Epigenomics; Genome / drug effects; Humans; National Institute of Environmental Health Sciences (U.S.); United States
TL;DR:
It is critical to determine whether epigenetic alterations are conserved across tissues in such a way that easily sampled surrogate tissues could be used to assess the impact of environmental exposure on diseaserelevant but inaccessible target tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 25, 2020
2018 personal communication
The NIEHS TaRGET II Consortium and environmental epigenomics
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Chemical Contributions to Neurodevelopmental Disorders
Policy Insights from the Behavioral and Brain Sciences, 4(2), 123–130.
Ed(s): S. Fiske
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2017 journal article
Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-SPA consortium study
NEUROTOXICOLOGY, 63, 33–42.
author keywords: Bisphenol A; Brain; Hypothalamus; Amygdala; Locus coeruleus; Sexually dimorphic
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Brain / drug effects; Brain / pathology; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Estrogens / pharmacology; Ethinyl Estradiol / pharmacology; Female; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR:
The testing of the hypothesis that perinatal BPA exposure would induce morphological changes in hormone sensitive, sexually dimorphic brain regions suggest the developing brain is vulnerable to endocrine disruption by BPA at exposure levels below previous estimates by regulatory agencies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Endocrine Disruption of Vasopressin Systems and Related Behaviors
Frontiers in Endocrinology, 8.
author keywords: bisphenol; oxytocin; sex differences; EDC; genistein; soy; social; anxiety; estrogens
TL;DR:
Endocrine disrupting chemicals shown to alter pathways and behaviors coordinated by AVP and/or OT include the plastics component bisphenol A (BPA), the soy phytoestrogen genistein (GEN), and various flame retardants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2017 article
Endocrine disrupting chemicals and behavior: Re-evaluating the science at a critical turning point
Barrett, E. S., & Patisaul, H. B. (2017, November). HORMONES AND BEHAVIOR, Vol. 96, pp. A1–A6.
TL;DR:
This work aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about infectious disease and its effects on health and the environment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Endocrine disruptors and the developing immune system
Current Opinion in Toxicology, 10, 31–36.
TL;DR:
The role of endocrine disruption in DIT is considered and endocrine disrupting chemicals (EDCs) with known DIT effects are highlighted, of special importance are microglia, the resident immune cells of the central nervous system that are highly influenced by endogenous endocrine signals during development and are therefore sensitive to effects from exposure to EDCs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2017 journal article
Environmental endocrine disruption of brain and behavior
Hormones, Brain and Behavior, Vol 5: Development of Hormone-Behavior Relationships, 3rd Edition, 63–88.
Source: NC State University Libraries
Added: August 6, 2018
2017 review
Neurodevelopmental and neurological effects of chemicals associated with unconventional oil and natural gas operations and their potential effects on infants and children
[Review of ]. REVIEWS ON ENVIRONMENTAL HEALTH, 33(1), 3–29.
author keywords: BTEX; children; EDCs; heavy metals; PAHs; particulate matter; UOG
MeSH headings : Adolescent; Air Pollutants / toxicity; Child; Child, Preschool; Congenital Abnormalities / etiology; Environmental Exposure / adverse effects; Humans; Infant; Infant, Newborn; Learning Disabilities / chemically induced; Natural Gas; Neurodevelopmental Disorders / chemically induced; Oil and Gas Industry; Petroleum; Water Pollutants, Chemical / toxicity
TL;DR:
Since UOG development has expanded rapidly in recent years, the need for public health prevention techniques, well-designed studies and stronger state and national regulatory standards is becoming increasingly apparent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study
NEUROTOXICOLOGY, 65, 207–220.
author keywords: Endocrine disruptor; EDC; Brain; Oxytocin; Sex difference; Estrogen; Androgen
MeSH headings : Amygdala / drug effects; Amygdala / metabolism; Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Ethinyl Estradiol / pharmacology; Female; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / metabolism; Rats; Sex Characteristics; Signal Transduction / drug effects; Transcriptome / drug effects
TL;DR:
It is demonstrated that that prenatal BPA exposure can disrupt the transcriptome of the neonate amygdala, at doses below the FDA No Observed Adverse Effect Level (NOAEL), in a sex‐specific manner and indicate that the female amygdala may be more sensitive to BPA Exposure during fetal development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats
SCIENTIFIC REPORTS, 7.
MeSH headings : Age Factors; Analysis of Variance; Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Female; Flame Retardants / adverse effects; Flame Retardants / analysis; Male; Molecular Structure; Placenta / drug effects; Placenta / metabolism; Pregnancy; Rats; Rats, Wistar; Sex Factors
TL;DR:
It is demonstrated that environmental chemicals may sex-dependently accumulate in the placenta, and that sex-biased exposure might translate to sex-specific adverse outcomes such as behavioral deficits.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours
Proceedings of the Nutrition Society, 76(2), 130–144.
author keywords: Soya; Isoflavones; Genistein; Equol; Endocrine disruption; Oestrogen; ER; ER; Brain; Hypothalamus
MeSH headings : Animals; Benzhydryl Compounds / adverse effects; Diet; Disease Models, Animal; Endocrine Disruptors / adverse effects; Humans; Isoflavones / adverse effects; Neurosecretory Systems / drug effects; Phenols / adverse effects; Phytoestrogens / adverse effects; Reproduction / drug effects; Sexual Behavior / drug effects; Sexual Behavior, Animal / drug effects; Soybeans / chemistry
TL;DR:
As oestrogen receptor partial agonists with molecular and cellular properties similar to anthropogenic endocrine disruptors such as bisphenol A, the soya phyto-oestrogens provide an interesting model for how attitudes about what is ‘synthetic’ v. what is‘natural,’ shapes understanding and perception of what it means for a compound to be endocrine disrupting and/or potentially harmful.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 17, 2019
2016 journal article
Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study
Endocrinology, 157(10), 3856–3872.
Contributors: S. Arambula n, S. Belcher n , A. Planchart n , S. Turner * & n
MeSH headings : Administration, Oral; Animals; Animals, Newborn; Benzhydryl Compounds / administration & dosage; Benzhydryl Compounds / toxicity; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / toxicity; Female; Gene Expression / drug effects; Hippocampus / drug effects; Hippocampus / metabolism; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Phenols / administration & dosage; Phenols / toxicity; Random Allocation; Rats; Rats, Sprague-Dawley; Sex Characteristics; Transcriptome / drug effects
TL;DR:
Preliminary data demonstrate prenatal BPA exposure, even at doses below the current no-observed-adverse-effect level, can alter gene expression in the developing brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2016 journal article
Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats
HORMONES AND BEHAVIOR, 84, 121–126.
author keywords: Endocrine disruption; Neuroendocrine disruption; Neuropeptides; Social; Diet; Open field; Affiliation; Activity; Environment
MeSH headings : Animals; Benzhydryl Compounds / pharmacology; Endocrine Disruptors / pharmacology; Exploratory Behavior / drug effects; Female; Isoflavones / pharmacology; Male; Phenols / pharmacology; Phytoestrogens / pharmacology; Rats; Sexual Behavior, Animal / drug effects; Social Behavior
TL;DR:
Testing the individual and combined effects of low dose oral BPA and soy diet or the individual isoflavone genistein on rat sociosexual behaviors with the hypothesis that soy would obfuscate any BPA-related effects reinforces that environmental factors can shape complex behaviors and even reverse expected sex differences.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Sex differences in microglial colonization and vulnerabilities to endocrine disruption in the social brain
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 238, 39–46.
author keywords: Vole; Rat; Hypothalamus; EDC; Sexual differentiation; Puberty
MeSH headings : Amygdala / cytology; Amygdala / drug effects; Animals; Animals, Newborn; Arvicolinae; Benzhydryl Compounds / toxicity; Brain / cytology; Brain / drug effects; Brain / growth & development; Dentate Gyrus / cytology; Dentate Gyrus / drug effects; Endocrine Disruptors / toxicity; Female; Male; Microglia / drug effects; Microglia / metabolism; Phenols / toxicity; Rats, Wistar; Sex Characteristics; Social Behavior; Somatosensory Cortex / cytology; Somatosensory Cortex / drug effects
TL;DR:
This work is the first to observe that developmental exposure to the synthetic estrogen ethinyl estradiol (EE) or BPA alters the sex-specific colonization of the hippocampus and amygdala by microglia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum
ACS Chemical Neuroscience, 8(2), 272–280.
author keywords: Biosensor; carbon fiber microelectrode; neuroenergetics; glucose oxidase; cocaine; fast-scan cyclic voltammetry
MeSH headings : Animals; Biophysics; Cocaine / pharmacology; Corpus Striatum / cytology; Corpus Striatum / diagnostic imaging; Corpus Striatum / drug effects; Corpus Striatum / metabolism; Dopamine / metabolism; Dopamine Antagonists / pharmacology; Dopamine Uptake Inhibitors / pharmacology; Drug Combinations; Electric Stimulation; Extracellular Fluid / metabolism; Glial Fibrillary Acidic Protein / metabolism; Glucose / metabolism; Hydrogen Peroxide / metabolism; Male; Microelectrodes; Raclopride / pharmacology; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
This work evaluates several waveforms to enable the first simultaneous detection of endogenous glucose and dopamine at single recording sites, and directly demonstrates the coupling of glucose availability with increased metabolic demand.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Transplacental and Lactational Transfer of Firemaster (R) 550 Components in Dosed Wistar Rats
TOXICOLOGICAL SCIENCES, 153(2), 246–257.
author keywords: Firemaster 550; lactational transfer; gestational transfer; metabolites; rodent
MeSH headings : Animals; Dose-Response Relationship, Drug; Female; Flame Retardants / pharmacokinetics; Lactation; Male; Maternal-Fetal Exchange; Placenta / metabolism; Pregnancy; Rats; Rats, Wistar
TL;DR:
This study is the first to confirm ip-PPP as a urinary metabolite of ITPs and establish a pharmacokinetic profile of FM 550 in a mammalian model.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 article
Assessment of sex specific endocrine disrupting effects in the prenatal and pre-pubertal rodent brain
Rebuli, M. E., & Patisaul, H. B. (2016, June). JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol. 160, pp. 148–159.
author keywords: Endocrine disrupting compounds; Neurodevelopment; Sex differences; Developmental exposure; Rodent; Bisphenol; BPA; Genistein; Xenoestrogen; EDC
MeSH headings : Animals; Brain / drug effects; Brain / embryology; Brain / growth & development; Endocrine Disruptors / pharmacology; Female; Male; Puberty / drug effects; Rodentia / embryology; Rodentia / growth & development; Sex Characteristics
TL;DR:
The developmental EDC exposure literature demonstrates evidence of altered neurodevelopment as early as fetal life, with sex specific effects observed throughout the brain even before puberty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Impact of Gestational Bisphenol A on Oxidative Stress and Free Fatty Acids: Human Association and Interspecies Animal Testing Studies
ENDOCRINOLOGY, 156(3), 911–922.
MeSH headings : Adult; Animals; Benzhydryl Compounds / blood; Benzhydryl Compounds / toxicity; Biomarkers; Environmental Pollutants; Fatty Acids, Nonesterified / metabolism; Female; Fetal Blood / chemistry; Fetus / drug effects; Humans; Hypopituitarism; Maternal Exposure; Mice; Oxidative Stress; Phenols / blood; Phenols / toxicity; Pregnancy; Rats; Species Specificity
TL;DR:
Evidence is provided of the induction of nitrosative stress by prenatal BPA in both the mother and fetus at time of birth and is thus supportive of the use of maternal NY as a biomarker for offspring health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study
TOXICOLOGICAL SCIENCES, 148(2), 341–354.
Contributors: M. Rebuli n, L. Camacho *, M. Adonay n, D. Reif n , D. Aylor n & n
author keywords: bisphenol A; CLARITY; behavior; anxiety; exploratory activity; endocrine disruption; EDC; sexually dimorphic; brain; BPA; plastic
MeSH headings : Age Factors; Animals; Anxiety / chemically induced; Anxiety / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Exploratory Behavior / drug effects; Female; Gestational Age; Lactation; Male; Maternal Exposure / adverse effects; Motor Activity / drug effects; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / psychology; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Risk Assessment; Sex Factors
TL;DR:
No consistent effects of BPA were observed for any endpoint, in either sex, at either age compared to vehicle controls; however, significant differences between BPA-exposed and ethinyl estradiol-exp exposed groups were identified for some endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring
REPRODUCTIVE TOXICOLOGY, 58, 282–294.
author keywords: Endocrine disruption; Genistein; Phytoestrogens; Behavior; Sexually dimorphic; Obesogen; Body weight; Metabolic
MeSH headings : Age Factors; Animal Nutritional Physiological Phenomena / drug effects; Animals; Benzhydryl Compounds / metabolism; Benzhydryl Compounds / toxicity; Dietary Proteins / metabolism; Dietary Proteins / toxicity; Eating / drug effects; Endocrine Disruptors / metabolism; Endocrine Disruptors / toxicity; Female; Genistein / metabolism; Genistein / toxicity; Male; Maternal Nutritional Physiological Phenomena / drug effects; Nutritional Status / drug effects; Obesity / chemically induced; Obesity / physiopathology; Phenols / metabolism; Phenols / toxicity; Phytoestrogens / metabolism; Phytoestrogens / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Risk Assessment; Sexual Maturation / drug effects; Soybean Proteins / metabolism; Soybean Proteins / toxicity; Weight Gain / drug effects
TL;DR:
Individual and combinatorial effects of soy diet or the isoflavone genistein with bisphenol A with BPA on body weight, ingestive behavior and female puberal onset in Wistar rats are assessed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
A Novel Model for Neuroendocrine Toxicology: Neurobehavioral Effects of BPA Exposure in a Prosocial Species, the Prairie Vole (Microtus ochrogaster)
ENDOCRINOLOGY, 155(10), 3867–3881.
MeSH headings : Affect / drug effects; Animals; Arvicolinae / physiology; Arvicolinae / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Defense Mechanisms; Endocrine Disruptors / toxicity; Environmental Exposure; Environmental Pollutants / toxicity; Female; Male; Models, Animal; Motor Activity / drug effects; Neurosecretory Systems / drug effects; Phenols / toxicity; Social Behavior; Toxicity Tests
TL;DR:
The hypothesis that BPA alters affective behaviors, potentially via disruption of OT/AVP pathways, is supported in the prairie vole, which is more prosocial than lab rats or mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components
Toxicology Letters, 228(2), 93–102.
Contributors: S. Belcher* , C. Cookman*, n & H. Stapleton *
author keywords: Apoptosis Endocrine disruptor; Flame retardant; Nuclear receptors; Obesity; Peroxisome proliferator-activated receptor
MeSH headings : Adipocytes / drug effects; Animals; CHO Cells; Caspase 3 / metabolism; Cell Survival / drug effects; Cricetinae; Cricetulus; Endocrine Disruptors / toxicity; Flame Retardants / toxicity; Humans; Ligands; Organophosphates / chemistry; Organophosphates / toxicity; Organotin Compounds / toxicity; PPAR gamma / drug effects; PPAR gamma / metabolism; Receptors, Cytoplasmic and Nuclear / drug effects; Transcriptional Activation / drug effects
TL;DR:
The resulting data indicated that the primary metabolic disruptive effects of FM 550 were likely mediated by the activity of the triarylphosphates at PPARγ, and have identified TPP as a candidate metabolic disruptor that also acts as a cytotoxicant.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2014 journal article
Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus
TOXICOLOGICAL SCIENCES, 140(1), 190–203.
author keywords: brain; endocrine disruptor; endocrine disruption; hypothalamus; development; subchronic exposure; sexually dimorphic; ethinyl estradiol; bisphenol A
MeSH headings : Aging / metabolism; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / genetics; Ethinyl Estradiol / toxicity; Female; Gene Expression / drug effects; Hypothalamus / drug effects; Hypothalamus / embryology; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / metabolism; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Sex Characteristics
TL;DR:
The impact of subchronic exposure from gestation to adulthood to oral doses of BPA below the current no-observed-adverse-effect level (NOAEL) of 5 mg/kg body weight (bw)/day on estrogen receptor (ESR) expression in sexually dimorphic brain regions of prepubertal and adult female rats is examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats
REPRODUCTIVE TOXICOLOGY, 49, 209–218.
author keywords: Phytoestrogens; Genistein; Endocrine disruptors; Ovary; Development
MeSH headings : Animals; Benzhydryl Compounds / adverse effects; Diet / adverse effects; Endocrine Disruptors / adverse effects; Female; Ovary / drug effects; Ovary / pathology; Phenols / adverse effects; Polycystic Ovary Syndrome / chemically induced; Polycystic Ovary Syndrome / pathology; Pregnancy; Rats; Rats, Wistar; Soy Foods / adverse effects; Testosterone / blood
TL;DR:
Lifetime exposure to a soy diet, containing endocrine active phytoestrogens, but not developmental exposure to the endocrine disrupting monomer bisphenol A (BPA), can induce key features of PCOS in the rat, results which support the hypothesis that hormonally active diets may contribute to risk when consumed throughout gestation and post-natal life.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II
CURRENT OPINION IN PHARMACOLOGY, 19, 145–152.
Contributors: D. Filer *, n , T. Schug*, D. Reif n & K. Thayer *
MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR:
Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Urinary Tetrabromobenzoic Acid (TBBA) as a Biomarker of Exposure to the Flame Retardant Mixture Firemaster ® 550
Environmental Health Perspectives, 122(9), 963–969.
MeSH headings : Adult; Aged; Animals; Biomarkers / metabolism; Bromobenzoates / urine; Dust / analysis; Environmental Exposure / analysis; Environmental Pollutants / urine; Female; Flame Retardants / metabolism; Hand; Humans; Male; Mass Spectrometry / methods; Middle Aged; Organophosphates / urine; Phthalic Acids / urine; Polybrominated Biphenyls / urine; Rats
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity
EPIGENETICS, 8(11), 1128–1132.
author keywords: neurodevelopmental toxicity; bisphenol A; chloride shift; KCC2; SLC12A5
MeSH headings : Air Pollutants, Occupational / adverse effects; Animals; Benzhydryl Compounds / adverse effects; Cerebral Cortex / metabolism; Chlorides / metabolism; Epigenesis, Genetic / drug effects; Female; Humans; Male; Nerve Tissue Proteins / metabolism; Neurons / metabolism; Phenols / adverse effects; Response Elements; Symporters / biosynthesis
TL;DR:
This commentary highlights recent discoveries in the arena of research at the interface of environmental toxicology and developmental neuroscience relating to toxicity mechanisms of bisphenol A, including the discovery that BPA disrupts the chloride shift in a sex-specific manner by recruiting epigenetics mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Designing endocrine disruption out of the next generation of chemicals
Green Chemistry, 15(1), 181–198.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Effects of environmental endocrine disruptors and phytoestrogens on the Kisspeptin system
Kisspeptin Signaling in Reproductive Biology, 784, 455–479.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Prenatal Bisphenol A Exposure Alters Sex-Specific Estrogen Receptor Expression in the Neonatal Rat Hypothalamus and Amygdala
TOXICOLOGICAL SCIENCES, 133(1), 157–173.
author keywords: brain; endocrine disruptor; endocrine disruption; hypothalamus; development; sexually dimorphic; ethinyl estradiol
MeSH headings : Amygdala / drug effects; Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / genetics; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Prenatal Exposure Delayed Effects / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Sex Factors
TL;DR:
Results indicate that ESR expression in the neonatal brain of both sexes can be altered by low-dose prenatal BPA exposure, and the potential for gavage to influence geneexpression in the developing brain is highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Sex specific impact of perinatal bisphenol A (BPA) exposure over a range of orally administered doses on rat hypothalamic sexual differentiation
NEUROTOXICOLOGY, 36, 55–62.
author keywords: Endocrine disruption; Estrogen; Hypothalamus; Sexually dimorphic; Dopamine
MeSH headings : Administration, Oral; Air Pollutants, Occupational / toxicity; Analysis of Variance; Animals; Benzhydryl Compounds / administration & dosage; Benzhydryl Compounds / toxicity; Calbindins / metabolism; Cell Count; Dose-Response Relationship, Drug; Female; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Phenols / administration & dosage; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Rats; Rats, Long-Evans; Sex Differentiation / physiology; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
It is demonstrated that early life oral exposure to BPA at levels well below the current No Observed Adverse Effect Level (NOAEL) of 50mg/kg/day can alter sex specific hypothalamic morphology in the rat.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 article
Sex-specific Esr2 mRNA expression in the rat hypothalamus and amygdala is altered by neonatal bisphenol A exposure
Cao, J., Joyner, L., Mickens, J. A., Leyrer, S. M., & Patisaul, H. B. (2014, April). REPRODUCTION, Vol. 147, pp. 537–554.
MeSH headings : Amygdala / drug effects; Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Rats; Rats, Long-Evans; Sex Factors; Sexual Behavior, Animal / drug effects; Social Behavior
TL;DR:
Testing the hypothesis that neonatal bisphenol A exposure can alter sex-specific postnatal Esr2 (Erβ) expression in brain regions fundamental to sociosexual behavior in rat demonstrates that region- and sex- specific EsR2 expression is vulnerable to neonatal BPA exposure in regions of the developing brain critical to socIosexual behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster®550 in Rats: An Exploratory Assessment
Journal of Biochemical and Molecular Toxicology, 27(2), 124–136.
Contributors: n , S. Roberts*, N. Mabrey n, K. Mccaffrey n, R. Gear*, J. Braun *, S. Belcher* , H. Stapleton *
author keywords: Anxiety; Cardiac Hypertrophy; Endocrine Disruptor; Flame Retardants; Metabolic Syndrome; Metabolism; Obesity; Obesogen; Polybrominated Diphenyl Ethers; Rodents
MeSH headings : Animals; Cardiomegaly / blood; Cardiomegaly / chemically induced; Cardiomegaly / pathology; Endocrine System / metabolism; Endocrine System / pathology; Endocrine System / physiology; Female; Flame Retardants / adverse effects; Male; Maternal Exposure / adverse effects; Obesity / blood; Obesity / chemically induced; Obesity / pathology; Pregnancy; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / pathology; Rats; Rats, Wistar; Thyroxine / blood
TL;DR:
Results are the first to implicate FM 550 as an endocrine disruptor and an obesogen at environmentally relevant levels and induced phenotypic hallmarks associated with metabolic syndrome in the offspring.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2012 journal article
Anxiogenic Effects of Developmental Bisphenol A Exposure Are Associated with Gene Expression Changes in the Juvenile Rat Amygdala and Mitigated by Soy
PLOS ONE, 7(9).
MeSH headings : Amygdala / drug effects; Animals; Anxiety / chemically induced; Anxiety / etiology; Benzhydryl Compounds / adverse effects; Estrogen Receptor beta / metabolism; Female; Gene Expression Profiling; Genistein / pharmacology; Maternal Exposure; Phenols / adverse effects; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; Receptors, Melanocortin / metabolism; Sex Characteristics; Soybeans / drug effects; Water / chemistry
TL;DR:
Results show that behavioral impacts of BPA can manifest during adolescence, but wane in adulthood, and may be mitigated by diet, and reveal that, because ERβ and melanocortin receptors are crucial to their function, oxytocin/vasopressin signaling pathways, which have been linked to human affective disorders, may underlie these behavioral outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Designing endocrine disruption out of the next generation of chemicals
Green Chem., 15(1), 181–198.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Crossref
Added: September 8, 2020
2012 journal article
Disrupted Organization of RFamide Pathways in the Hypothalamus Is Associated with Advanced Puberty in Female Rats Neonatally Exposed to Bisphenol A
BIOLOGY OF REPRODUCTION, 87(2).
author keywords: endocrine disruptor; kisspeptin; puberty; RFRP
MeSH headings : Animals; Benzhydryl Compounds; Body Weight / drug effects; Estrogens, Non-Steroidal / toxicity; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Kisspeptins / metabolism; Male; Neuropeptides / metabolism; Phenols / toxicity; Puberty, Precocious / blood; Puberty, Precocious / chemically induced; Rats; Rats, Transgenic; Rats, Wistar; Vagina / drug effects
TL;DR:
Data suggest that BPA-induced premature puberty results from decreased inhibition of GnRH neurons, which are critical for initiating puberty and maintaining estrous cyclicity by stimulating gonadotropin-releasing hormone (GnRH) release.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 article
Infertility in the Southern White Rhino: Is Diet the Source of the Problem?
Patisaul, H. B. (2012, April). ENDOCRINOLOGY, Vol. 153, pp. 1568–1571.
MeSH headings : Animals; Coumestrol / pharmacology; Female; Humans; Isoflavones / pharmacology; Receptors, Estrogen / metabolism
TL;DR:
Evidence is provided that the fertility of captive rhinos is being compromised, not by malnutrition but through endocrine disruption by phytoestrogens, which appears to be contributing to the reproductive impairments reported in captive born Southern White Rhinoceros.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Influence of ERβ selective agonism during the neonatal period on the sexual differentiation of the rat hypothalamic-pituitary-gonadal (HPG) axis
Biology of Sex Differences, 3(1), 2.
TL;DR:
The results indicate that selective agonism of ERβ is not sufficient to completely achieve male-typical HPG organization observed with EB or an ERα agonist.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2012 journal article
Reproductive consequences of developmental phytoestrogen exposure
REPRODUCTION, 143(3), 247–260.
MeSH headings : Animals; Child Development / drug effects; Diet; Humans; Infant; Infant Food / adverse effects; Infant Formula / chemistry; Infant, Newborn; Phytoestrogens / adverse effects; Phytoestrogens / pharmacology; Reproduction / drug effects; Reproduction / physiology
TL;DR:
The aim of this review is to examine the evidence that phytoestrogen exposure, particularly in the developmentally sensitive periods of life, has consequences for future reproductive health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Sex-specific expression of estrogen receptors α and β and Kiss1 in the postnatal rat amygdala
Journal of Comparative Neurology, 521(2), 465–478.
author keywords: development; kisspeptin; sexually dimorphic; hypothalamus; neonatal
MeSH headings : Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Estrogen Receptor alpha / biosynthesis; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / biosynthesis; Estrogen Receptor beta / genetics; Female; Hippocampus / metabolism; Image Processing, Computer-Assisted; In Situ Hybridization; Kisspeptins / biosynthesis; Kisspeptins / genetics; Male; Pregnancy; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Maturation
TL;DR:
Data reveal that ER expression is region‐specific within the neonatal amygdala, which likely contribute to sex differences in sociosexual behavior across the lifespan.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 review
Endocrine Disrupters: A Review of Some Sources, Effects, and Mechanisms of Actions on Behaviour and Neuroendocrine Systems
[Review of ]. JOURNAL OF NEUROENDOCRINOLOGY, 24(1), 144–159.
author keywords: xenoestrogens; dichloro diphenyl trichloroethane; methoxychlor; biocides; tributyltin; bisphenol A; diethylstilbestrol; ethinylestradiol; phytoestrogens; aryl hydrocarbon receptor; the peroxisome proliferator-activated receptor; retinoid X receptor
MeSH headings : Animals; Behavior, Animal / drug effects; Benzhydryl Compounds; Brain / drug effects; Endocrine Disruptors / pharmacology; Environmental Pollutants / pharmacology; Humans; Phenols / pharmacology; Phytoestrogens / pharmacology; Puberty / drug effects; Reproduction / drug effects
TL;DR:
EDCs, from varied sources, may have organisational effects during development and/or activational effects in adulthood that influence sexually‐dimorphic, reproductively‐relevant processes or other functions, by mimicking, antagonising or altering steroidal actions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Neonatal Bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus
NeuroToxicology, 33(1), 23–36.
author keywords: Kisspeptin; Estrogen receptor; Sexual differentiation; Development; Brain; Endocrine disruption
MeSH headings : Age Factors; Analysis of Variance; Animals; Animals, Newborn; Benzhydryl Compounds; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Estrogens, Non-Steroidal / pharmacology; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; Male; Phenols / pharmacology; RNA, Messenger / metabolism; Rats; Rats, Long-Evans; Sex Characteristics
TL;DR:
Results show that neonatal hypothalamic ER and Kiss1 expression is sensitive to BPA exposure, and discordant effects of EB and BPA indicate that BPA likely disrupts hypothalamic organization by a mechanism other than simply acting as an estrogen mimic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2011 journal article
Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness
Hormones and Behavior, 60(2), 185–194.
author keywords: Sex behavior; Endocrine disruptor; Genistein; Estrogen receptor; Partner preference; DPN; Estrogen; Masculinization; Virility; Soy
MeSH headings : Animals; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / agonists; Estrogen Receptor beta / metabolism; Estrogens / pharmacology; Genistein / pharmacology; Male; Mating Preference, Animal / drug effects; Nitriles / pharmacology; Phenols / pharmacology; Phytoestrogens / pharmacology; Propionates / pharmacology; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Sexual Behavior, Animal / drug effects
TL;DR:
DPN had a greater adverse impact than PPT on reproductive behavior, suggesting a functional role for ERβ in the organization of these male-specific behaviors and EB exposure significantly lowered the testis to body weight ratio, and circulating testosterone levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 article
On the Need for a National (US) Research Program to Elucidate the Potential Risks to Human Health and the Environment Posed by Contaminants of Emerging Concern
Novak, P. J., Arnold, W. A., Blazer, V. S., Halden, R. U., Klaper, R. D., Kolpin, D. W., … Swackhamer, D. L. (2011, May 1). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 45, pp. 3829–3830.
MeSH headings : Animals; Environmental Health / trends; Environmental Pollutants / adverse effects; Environmental Pollution / adverse effects; Humans; Public Health / trends; Research / trends; United States
TL;DR:
This dissertation aims to provide a history of sustainable water management practices in the United States from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including World War II.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Sexually dimorphic expression of hypothalamic estrogen receptors α and β and kiss1 in neonatal male and female rats
The Journal of Comparative Neurology, 519(15), 2954–2977.
author keywords: development; anteroventral periventricular nucleus (AVPV); medial preoptic area (MPOA); arcuate nucleus (ARC); kisspeptin; sex differences
MeSH headings : Animals; Autoradiography; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / genetics; Estrogen Receptor beta / metabolism; Female; Hypothalamus / anatomy & histology; Hypothalamus / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; Male; Neurons / cytology; Neurons / metabolism; Pregnancy; Rats; Sex Characteristics; Signal Transduction / physiology
TL;DR:
Detailed profiles of neonatal Kiss1 and ERs mRNA levels will help elucidate the relative roles each plays in the sex‐specific, estrogen‐dependent organization of gonadotropin signaling pathways and provide evidence that Kiss1 may play a role in the sexual dimorphic organization of the neonatal brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 333(2), 151–159.
author keywords: Dioxin; Ahr; Antiestrogen; Prl; LH; Estradiol
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / genetics; Aryl Hydrocarbon Hydroxylases / metabolism; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A1 / metabolism; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 CYP1A2 / metabolism; Cytochrome P-450 CYP1B1; Estradiol / pharmacology; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Female; Gene Expression Regulation / drug effects; Glycoprotein Hormones, alpha Subunit / genetics; Glycoprotein Hormones, alpha Subunit / metabolism; Gonadotrophs / cytology; Gonadotrophs / drug effects; Gonadotrophs / metabolism; Immunohistochemistry; In Situ Hybridization; Lactotrophs / cytology; Lactotrophs / drug effects; Lactotrophs / metabolism; Luteinizing Hormone, beta Subunit / genetics; Luteinizing Hormone, beta Subunit / metabolism; Pituitary Gland / cytology; Pituitary Gland / drug effects; Pituitary Gland / enzymology; Polychlorinated Dibenzodioxins / pharmacology; Prolactin / genetics; Prolactin / metabolism; Protein Precursors / genetics; Protein Precursors / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism
TL;DR:
It is found that TCDD upregulated known AhR target genes, cytochrome p450 1a1 (Cyp1a1), Cyp1a2 and Cyp1b1 in the rat pituitary gland, and complex interactions between Ahr and Esr alter Prl and luteinizing hormone (LH) synthesis by direct actions in lactotropes and gonadotropes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Assessing Risks from Bisphenol A Evaluating human health risks from endocrine disruptors' such as BPA is difficult, but animal studies suggest trouble is afoot
AMERICAN SCIENTIST, 98(1), 30–39.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Endocrine Disruption of Brain Sexual Differentiation by Developmental PCB Exposure
ENDOCRINOLOGY, 152(2), 581–594.
MeSH headings : Animals; Estrogen Receptor alpha / metabolism; Female; Gonadotropin-Releasing Hormone / metabolism; Immunohistochemistry; Insulin-Like Growth Factor I / genetics; Kisspeptins; Male; Neurosecretory Systems / drug effects; Polychlorinated Biphenyls / pharmacology; Polymerase Chain Reaction; Pregnancy; Preoptic Area; Proteins / metabolism; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Androgen / genetics; Receptors, N-Methyl-D-Aspartate / genetics; Sex Differentiation / drug effects; Transforming Growth Factor beta / genetics
TL;DR:
The hypothesis that perinatal exposure to polychlorinated biphenyls (PCBs) that disrupt hormonal pathways would perturb reproductive maturation and the sexually dimorphic development of neuroendocrine systems in the preoptic area (POA) is tested and data suggest that developmental PCBs profoundly impair the sexual differentiation of the female hypothalamus.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat
REPRODUCTIVE TOXICOLOGY, 31(3), 280–289.
author keywords: Soy; Estrogen; Phytoestrogens; Endocrine disruptors; Development; Reproductive; Fertility; Ovary
MeSH headings : Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / pathology; Female; Gene Expression Regulation, Developmental / drug effects; Genistein / toxicity; Hypothalamus / drug effects; Hypothalamus / metabolism; Immunohistochemistry; In Situ Hybridization; Kisspeptins; Midline Thalamic Nuclei / drug effects; Midline Thalamic Nuclei / metabolism; Midline Thalamic Nuclei / pathology; Ovary / drug effects; Ovary / growth & development; Phytoestrogens / toxicity; Proteins / genetics; Proteins / metabolism; RNA, Messenger / analysis; Rats; Rats, Long-Evans; Rats, Wistar; Sex Factors; Sexual Maturation / drug effects; Sexual Maturation / physiology; Signal Transduction / drug effects
TL;DR:
Female rats exposed to the phytoestrogen genistein, estradiol benzoate, or vehicle from post natal day (P) 0-3 via subcutaneous injection were exposed to estrogenic endocrine disrupting compounds to establish sex specific development of KISS gene expression, cell number and neural fiber density across peripuberty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 article
Neuroendocrine disruption: Historical roots, current progress, questions for the future
Gore, A. C., & Patisaul, H. B. (2010, October). FRONTIERS IN NEUROENDOCRINOLOGY, Vol. 31, pp. 395–399.
MeSH headings : Animals; Endocrine Disruptors / history; Endocrine Disruptors / toxicity; Female; History, 20th Century; History, 21st Century; Humans; Male; Neurosecretory Systems / drug effects; Rats
TL;DR:
Rapidly emerging data from numerous labs conducting basic animal research, studies of inadvertent human exposures, and epidemiological analyses overwhelmingly point to the inevitable conclusion that EDC exposures are pervasive, and cause both short- and long-term harm to humans and wildlife.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat
NEUROTOXICOLOGY, 32(1), 38–49.
author keywords: Xenoestrogen; Endocrine disruption; Brain; Sexual differentiation; Development; Estrogen receptor; Neuroendocrine
MeSH headings : Age Factors; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / growth & development; Benzhydryl Compounds; Body Weight / drug effects; Body Weight / physiology; Female; Phenols / toxicity; Preoptic Area / drug effects; Preoptic Area / growth & development; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology; Ventromedial Hypothalamic Nucleus / drug effects; Ventromedial Hypothalamic Nucleus / growth & development
TL;DR:
The results of this and a prior study indicate that the impact of neonatal BPA Exposure within the female rat hypothalamus is region specific and support the hypothesis that developmental BPA exposure may adversely affect reproductive development in females.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 review
The pros and cons of phytoestrogens
[Review of ]. FRONTIERS IN NEUROENDOCRINOLOGY, 31(4), 400–419.
author keywords: Soy; Isoflavones; Genistein; Equol; Endocrine disruption; Estrogen; ER alpha; ER beta; Brain; Hypothalamus
MeSH headings : Animals; Brain / drug effects; Brain / growth & development; Breast Neoplasms / prevention & control; Diethylstilbestrol / adverse effects; Endocrine Disruptors / adverse effects; Endocrine Disruptors / pharmacology; Female; Genitalia / drug effects; Genitalia / growth & development; Heart Diseases / prevention & control; Humans; Male; Menopause / drug effects; Menstrual Cycle / drug effects; Mice; Osteoporosis / prevention & control; Phytoestrogens / adverse effects; Phytoestrogens / pharmacology; Puberty / drug effects; Rats; Sexual Behavior / drug effects; Soybean Proteins / adverse effects; Soybean Proteins / pharmacology
TL;DR:
As weak estrogen agonists/antagonists with molecular and cellular properties similar to synthetic endocrine disruptors such as Bisphenol A (BPA), the phytoestrogens provide a useful model to comprehensively investigate the biological impact of endocrine disruption in general.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Impact of neonatal exposure to the ERα agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats
NeuroToxicology, 30(3), 350–357.
author keywords: Bisphenol; Phytoestrogens; Soy; Genistein; Equal; Gonadotropins; Development; Disruption; Estrogen; Estrogen receptor; GnRH; KISS
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Female; Hypothalamus / anatomy & histology; Kisspeptins; Male; Nerve Fibers / drug effects; Nerve Fibers / metabolism; Ovariectomy; Phenols / pharmacology; Phytoestrogens / pharmacology; Progesterone / pharmacology; Proteins / metabolism; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Sex Characteristics
TL;DR:
The results suggest that the organization of hypothalamic KISS fibers may be vulnerable to disruption by EDC exposure and that females might be more sensitive than males.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior
Frontiers in Behavioral Neuroscience, 3, 10.
author keywords: bisphenol; genistein; soy; estrogen receptors; development; sexual differentiation
TL;DR:
An overview of how exposure to EDCs, particularly those that interfere with estrogen action, impacts reproductive physiology and behaviors in vertebrates is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 25, 2019
2009 journal article
Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin-Releasing Hormone Neurons
BIOLOGY OF REPRODUCTION, 81(4), 690–699.
author keywords: AVPV; corpora lutea; development; disruption; endocrine disruptors; ER alpha; ESR1; estradiol; estradiol receptor; estrogen; estrogen receptor; GnRH; gonad; hypothalamus; lordosis; neuroendocrinology; ovary; PPT; puberty
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Dose-Response Relationship, Drug; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / toxicity; Estrous Cycle / drug effects; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Neuroendocrine Cells / drug effects; Ovary / drug effects; Ovary / pathology; Phenols / administration & dosage; Phenols / toxicity; Proto-Oncogene Proteins c-fos / metabolism; Rats; Rats, Long-Evans; Sexual Behavior, Animal / drug effects; Sexual Maturation / drug effects
TL;DR:
The data suggest that BPA disrupts ovarian development but not the ability of GnRH neurons to respond to steroid-positive feedback.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Progesterone and medroxyprogesterone acetate differentially regulate α4 subunit expression of GABAA receptors in the CA1 hippocampus of female rats
Physiology & Behavior, 97(1), 58–61.
author keywords: Allopregnanolone; Neurosteroids; GABA(A) receptors
MeSH headings : Animals; Drug Interactions; Estradiol / administration & dosage; Estradiol / analogs & derivatives; Female; Hippocampus / drug effects; Hippocampus / metabolism; Medroxyprogesterone Acetate / administration & dosage; Medroxyprogesterone Acetate / pharmacology; Ovariectomy; Progesterone / administration & dosage; Progesterone / pharmacology; RNA, Messenger / metabolism; Rats; Rats, Long-Evans; Receptors, GABA-A / metabolism
TL;DR:
MPA, while progestational in terms of its effects in the uterus, is not a simple substitute for P4 in other systems, and the relative impact of these two progestins on neuroendocrine function must be carefully explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2008 review
Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus
[Review of ]. NEUROTOXICOLOGY, 29(6), 988–997.
author keywords: Genistein; Equal; Soy; Isoflavones; Gonadotropin; Puberty; Development; Endocrine disruption; DPN; PPT
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrous Cycle / drug effects; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Kisspeptins; Nerve Fibers / metabolism; Phenols / pharmacology; Proteins / metabolism; Pyrazoles / pharmacology; Rats; Receptors, Estrogen / agonists; Reproductive Physiological Phenomena / drug effects
TL;DR:
The data suggest that neonatal exposure to EDCs can suppress GnRH activity in adulthood, and that ERalpha plays a pivotal role in this process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Neonatal agonism of ERα masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis
Behavioural Brain Research, 196(2), 317–322.
author keywords: Estrogen; Development; Hypothalamus; Serotonin; Sex differences; Estrogen receptor; DPN; PPT
MeSH headings : Animals; Animals, Newborn / physiology; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / physiology; Estrogen Receptor beta / agonists; Female; Male; Neural Pathways / physiology; Nitriles / pharmacology; Phenols / pharmacology; Propionates / pharmacology; Pyrazoles / pharmacology; Rats; Serotonin / physiology; Sex Characteristics; Sexual Behavior, Animal / physiology; Ventromedial Hypothalamic Nucleus / physiology
TL;DR:
Observations show that postnatal estrogens increase the density of 5-HT projections to the VMNvl via an ERalpha dependent mechanism, but that this increased inhibitory input is not sufficient to suppress the lordosis response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Neonatal exposure to endocrine active compounds or an ERβ agonist increases adult anxiety and aggression in gonadally intact male rats
Hormones and Behavior, 53(4), 580–588.
author keywords: DPN; PPT; bisphenol; equol; estrogen; phytoestrogens; soy isoflavones; EAC; endocrine disruptors
MeSH headings : Age Factors; Aggression / drug effects; Aggression / physiology; Analysis of Variance; Animals; Animals, Newborn; Anxiety / metabolism; Benzhydryl Compounds; Endocrine Disruptors / pharmacology; Equol; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / agonists; Estrogen Receptor beta / drug effects; Estrogen Receptor beta / metabolism; Isoflavones / pharmacology; Male; Nitriles / pharmacology; Phenols / pharmacology; Propionates / pharmacology; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Statistics, Nonparametric; Testis / drug effects; Testis / metabolism
TL;DR:
It is suggested that neonatal exposure to EACs with agonistic activity on ERbeta may influence affective behavior in adulthood, including anxiety and aggression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats
HORMONES AND BEHAVIOR, 55(2), 319–328.
Contributors: n , K. Burke n, R. Hinkle n, H. Adewale n & D. Shea n
author keywords: DPN; PPT; Estrogen; Soy isoflavones; Testosterone; Anxiety; Endocrine active compound; Resveratrol; Equol; Plus maze; ER beta; Estrogen receptor beta
MeSH headings : Analysis of Variance; Animals; Anti-Anxiety Agents / administration & dosage; Anxiety / drug therapy; Behavior, Animal / drug effects; Equol; Estrogen Receptor alpha / agonists; Isoflavones / administration & dosage; Male; Nitriles / administration & dosage; Nitriles / blood; Phenols; Phytoestrogens / administration & dosage; Propionates / administration & dosage; Propionates / blood; Pyrazoles / administration & dosage; Rats; Rats, Long-Evans; Rats, Wistar; Resveratrol; Stilbenes / administration & dosage; Testosterone / blood
TL;DR:
It is determined that DPN can be successfully administered either orally or by subcutaneous injection, although plasma DPN levels are significantly lower if given orally, and the efficacy of ERbeta agonists may depend on gonadal status, therefore the therapeutic potential of ER beta selective agonists to treat mood disorders may be limited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2007 journal article
Influence of endocrine active compounds on the developing rodent brain
Brain Research Reviews, 57(2), 352–362.
author keywords: hypothalamus; estrogen receptor; development; sexually dimorphic; phytoestrogen; genistein; bisphenol
MeSH headings : Animals; Benzhydryl Compounds; Brain / drug effects; Brain / growth & development; Brain / pathology; Endocrine Disruptors / toxicity; Estrogens, Non-Steroidal / toxicity; Female; Genistein / toxicity; Male; Mice; Phenols / toxicity; Protein Kinase Inhibitors / toxicity; Rats; Sex Characteristics
TL;DR:
It is demonstrated that nuclear volume is likely not an appropriate biomarker for EAC exposure and that neonatal exposure to the EACs genistein and Bisphenol-A can affect sexually dimorphic brain morphology and neuronal phenotypes in adulthood with regional and cellular specificity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2007 journal article
Sex Differences in Serotonergic But Not γ-Aminobutyric Acidergic (GABA) Projections to the Rat Ventromedial Nucleus of the Hypothalamus
Endocrinology, 149(1), 397–408.
MeSH headings : Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / metabolism; Dorsomedial Hypothalamic Nucleus / metabolism; Estradiol / pharmacology; Female; Genistein / pharmacology; Glutamate Decarboxylase / metabolism; Male; Neurons, Afferent / drug effects; Neurons, Afferent / metabolism; Neurons, Afferent / physiology; Posture / physiology; Rats; Rats, Sprague-Dawley; Serotonin / metabolism; Sex Characteristics; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology; Ventromedial Hypothalamic Nucleus / drug effects; Ventromedial Hypothalamic Nucleus / metabolism; Ventromedial Hypothalamic Nucleus / physiology; gamma-Aminobutyric Acid / metabolism
TL;DR:
The findings suggest that the development of serotonergic inputs to the male VMNvl is orchestrated by neonatal estradiol exposure, and the hormone-dependent organization of these 5-HT projection patterns may be an important developmental mechanism accounting for sex-specific behaviors in adulthood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2006 journal article
Differential disruption of nuclear volume and neuronal phenotype in the preoptic area by neonatal exposure to genistein and bisphenol-A
NEUROTOXICOLOGY, 28(1), 1–12.
author keywords: AVPV; SDN; calbindin; estrogen; development; endocrine disruptor
MeSH headings : Animals; Animals, Newborn / physiology; Benzhydryl Compounds; Biomarkers; Calbindins; Estrogens, Non-Steroidal / toxicity; Female; Genistein / toxicity; Immunohistochemistry; Neurons / drug effects; Neurons / pathology; Oncogene Proteins v-fos / metabolism; Orchiectomy; Paraventricular Hypothalamic Nucleus / anatomy & histology; Paraventricular Hypothalamic Nucleus / drug effects; Paraventricular Hypothalamic Nucleus / growth & development; Phenols / toxicity; Phenotype; Pregnancy; Preoptic Area / anatomy & histology; Preoptic Area / drug effects; Preoptic Area / growth & development; Rats; Rats, Sprague-Dawley; Receptors, LHRH / drug effects; Receptors, LHRH / metabolism; S100 Calcium Binding Protein G / metabolism; Sex Characteristics
TL;DR:
The results suggest that acute exposure to EACs during a critical developmental period can independently alter nuclear volumes of sexually dimorphic nuclei and their phenotypic profiles in a region specific manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV☆
Neurotoxicology and Teratology, 28(1), 111–118.
author keywords: phytoestrogens; ER alpha; tyrosine hydroxylase; rat; development; hypothalamus
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Cell Count; Cell Differentiation / drug effects; Cell Differentiation / physiology; Disease Models, Animal; Estradiol / metabolism; Estradiol / pharmacology; Estradiol Congeners / toxicity; Estrogen Receptor alpha / drug effects; Estrogen Receptor alpha / metabolism; Estrogens, Non-Steroidal / adverse effects; Female; Genistein / toxicity; Growth Inhibitors / toxicity; Male; Nervous System Malformations / chemically induced; Nervous System Malformations / pathology; Nervous System Malformations / physiopathology; Phenols / toxicity; Pregnancy; Preoptic Area / abnormalities; Preoptic Area / drug effects; Preoptic Area / physiopathology; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sex Differentiation / drug effects; Sex Differentiation / physiology; Tyrosine 3-Monooxygenase / drug effects; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
It is hypothesized that exposure to EACs during this critical period could alter the sexually dimorphic expression of TH and the overall expression of estrogen receptor alpha (ERalpha) in the AVPV and identified a population of neurons co-expressing TH and ERalpha located primarily in the medial region of the A VPV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2005 journal article
Dietary Soy Supplements Produce Opposite Effects on Anxiety in Intact Male and Female Rats in the Elevated Plus-Maze.
Behavioral Neuroscience, 119(2), 587–594.
author keywords: phytoestrogens; soy; stress; estrogen; endocrine disruptors
MeSH headings : Animals; Anxiety; Dietary Supplements; Estrus; Female; Male; Maze Learning; Phytoestrogens / pharmacology; Rats; Rats, Long-Evans; Sex Factors; Soybean Proteins / pharmacology
TL;DR:
The results suggest that the soy supplements have sex- and cycle-specific effects on anxiety, as serum estrogen and progesterone levels were unaffected by diet in the females.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2005 journal article
Phytoestrogen Action in the Adult and Developing Brain
Journal of Neuroendocrinology, 17(1), 57–64.
author keywords: soy; phytoestrogens; coumestrol; isoflavones; genistein; daidzein; endocrine disrupters; oestrogen; sex behaviour; ER alpha; ER beta; brain; hypothalamus
MeSH headings : Adult; Animals; Brain / drug effects; Brain / growth & development; Dietary Supplements; Humans; Infant; Phytoestrogens / administration & dosage; Phytoestrogens / chemistry; Soy Foods
TL;DR:
The activational and organisational effects of these compounds on the brain are reviewed and small, physiologically relevant exposure levels can alter oestrogen‐dependent gene expression in the brain and affect complex behaviour in a wide range of species.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2004 journal article
A soy supplement and tamoxifen inhibit sexual behavior in female rats
Hormones and Behavior, 45(4), 270–277.
author keywords: pacing; lordosis; soy; isoflavone; phytoestrogen; SERM; sex
MeSH headings : Analysis of Variance; Animals; Dietary Supplements; Drug Combinations; Estradiol / physiology; Estrogen Antagonists / pharmacology; Estrogens, Non-Steroidal / pharmacology; Female; Genistein / pharmacology; Isoflavones / pharmacology; Male; Posture; Progesterone / physiology; Rats; Rats, Long-Evans; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology; Soy Foods; Tamoxifen / pharmacology
TL;DR:
Results demonstrate that both the soy supplement and TAMOX act as estrogen antagonists on both proceptive and receptive behavior in female rats.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2004 chapter
Dietary Phytoestrogens
In Endocrine Disruptors (pp. 135–173).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2003 journal article
Immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus
Brain Research, 978(1-2), 185–193.
author keywords: selective estrogen receptor modulator; ER beta; ER alpha; estrogen; hypothalamus; progesterone
MeSH headings : Animals; Autoradiography; Binding Sites; Drug Administration Schedule / veterinary; Estradiol Congeners / adverse effects; Estradiol Congeners / pharmacology; Estrogen Antagonists / adverse effects; Estrogen Antagonists / pharmacology; Ethinyl Estradiol / adverse effects; Ethinyl Estradiol / pharmacology; Fallopian Tubes / drug effects; Female; Gene Expression Regulation / drug effects; Hypothalamus / drug effects; Hypothalamus / metabolism; In Situ Hybridization; Organ Size / drug effects; RNA, Messenger / biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin / genetics; Receptors, Oxytocin / metabolism; Receptors, Progesterone / genetics; Receptors, Progesterone / metabolism; Reverse Transcriptase Polymerase Chain Reaction / methods; Tamoxifen / adverse effects; Tamoxifen / pharmacology; Time Factors; Vasotocin / analogs & derivatives; Vasotocin / pharmacokinetics
TL;DR:
The results suggest that TAMOX has mixed agonist/antagonist effects in the female rat brain, many of which persist at least 2 weeks after the administration ceases.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2003 journal article
Oxytocin, But Not Oxytocin Receptor, is Regulated by Oestrogen Receptor β in the Female Mouse Hypothalamus
Journal of Neuroendocrinology, 15(8), 787–793.
author keywords: oestrogen; ER beta; paraventricular nucleus; supraoptic nucleus; ER alpha
MeSH headings : Animals; Autoradiography; Estrogen Receptor beta; Estrogens / pharmacology; Female; Gene Expression / drug effects; Gene Expression / physiology; Hypothalamus, Anterior / metabolism; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovariectomy; Oxytocin / genetics; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / metabolism; Progesterone / pharmacology; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Receptors, Oxytocin / metabolism; Vasopressins / genetics; Vasopressins / metabolism
TL;DR:
It is suggested that ERβ is necessary for the regulation of the expression of oxytocin in the PVN, and region and peptide specific regulation by ERα and ERβ in the mouse hypothalamus is shown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2002 journal article
Genistein Affects ERβ- But Not ERα-Dependent Gene Expression in the Hypothalamus
Endocrinology, 143(6), 2189–2197.
MeSH headings : Animals; Autoradiography; Brain Chemistry / drug effects; Diet; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens / blood; Estrogens, Non-Steroidal / blood; Estrogens, Non-Steroidal / pharmacology; Female; Gene Expression Regulation / drug effects; Genistein / blood; Genistein / pharmacology; Hypothalamus / drug effects; Hypothalamus / metabolism; In Situ Hybridization; Male; RNA, Messenger / biosynthesis; Radioimmunoassay; Rats; Rats, Long-Evans; Receptors, Estrogen / biosynthesis; Receptors, Estrogen / genetics; Receptors, Oxytocin / drug effects; Receptors, Oxytocin / metabolism; Sexual Behavior, Animal / drug effects; Sexual Maturation / physiology; Uterus / drug effects; Uterus / growth & development
TL;DR:
The impact of the soy isoflavone genistein, a major component of the supplement, on estrogen-dependent female sexual behavior and ERα- and ERβ-dependent gene expression in the rat brain is examined.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2002 journal article
Neurobehavioral actions of coumestrol and related isoflavonoids in rodents
Neurotoxicology and Teratology, 24(1), 47–54.
author keywords: phytoestrogens; coumestrol; isoflavones; genistein; daidzein; endocrine disrupters; estrogen; sex behavior; ER alpha; ER beta
MeSH headings : Animals; Animals, Suckling; Coumestrol / pharmacology; Estrogens, Non-Steroidal / pharmacology; Female; Gene Expression / drug effects; Isoflavones / pharmacology; Male; Mice; Rats; Receptors, Estrogen / genetics; Sexual Behavior, Animal / drug effects
TL;DR:
It is shown that even small, physiologically relevant exposure levels can alter estrogen-dependent gene expression in the brain and complex behavior, and that, in spite of their preferential affinity for ERbeta, isoflavonoids act through both ER(alpha) and ERbeta.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2001 journal article
Coumestrol Antagonizes Neuroendocrine Actions of Estrogen via the Estrogen Receptor α
Experimental Biology and Medicine, 226(4), 301–306.
author keywords: phytoestrogen; progesterone receptor; luteinizing hormone; nutrition; estrogen receptor beta
MeSH headings : Animals; Brain / drug effects; Brain / metabolism; Coumestrol / administration & dosage; Coumestrol / pharmacology; Drug Evaluation, Preclinical; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogen Receptor alpha; Estrogens, Non-Steroidal / pharmacology; Female; Hypothalamus / drug effects; Hypothalamus / metabolism; Luteinizing Hormone / blood; Mice; Mice, Knockout; Ovariectomy; Receptors, Estrogen / antagonists & inhibitors; Receptors, Estrogen / deficiency; Receptors, Estrogen / genetics; Receptors, Progesterone / analysis
TL;DR:
Results show that coumestrol has anti-estrogenic actions in the brain and pituitary and that ERα mediates these effects.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2001 journal article
Cross-species and interassay comparisons of phytoestrogen action.
Environmental Health Perspectives, 109(suppl 1), 5–20.
MeSH headings : Animals; Biological Assay / methods; Bone Density / drug effects; Breast / drug effects; Breast / pathology; Cell Division / drug effects; Diet; Dose-Response Relationship, Drug; Endocrine System / drug effects; Estrogens / agonists; Humans; Hypothalamo-Hypophyseal System / drug effects; Plant Growth Regulators / pharmacology; Urogenital System / drug effects; Urogenital System / pathology
TL;DR:
The similarity of reported proliferative and antiproliferative doses illustrates the need for fuller examination of dose-response relationships and multiple end points in assessing phytoestrogen actions.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2001 journal article
Soy Isoflavone Supplements Antagonize Reproductive Behavior and Estrogen Receptor α- and β-Dependent Gene Expression in the Brain*
Endocrinology, 142(7), 2946–2952.
MeSH headings : Animals; Brain / physiology; Chromatography, High Pressure Liquid; Estradiol / metabolism; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression / drug effects; Isoflavones / analysis; Isoflavones / pharmacology; Male; RNA, Messenger / metabolism; Rats; Rats, Long-Evans; Receptors, Estrogen / genetics; Receptors, Estrogen / physiology; Receptors, Oxytocin / metabolism; Sexual Behavior, Animal / drug effects; Soybeans / chemistry; Uterus / drug effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
1999 journal article
Regulation of estrogen receptor beta mRNA in the brain: opposite effects of 17β-estradiol and the phytoestrogen, coumestrol
Molecular Brain Research, 67(1), 165–171.
author keywords: paraventricular nucleus; 17 beta-estradiol; ER beta; phytoestrogen; endocrine disruptor
MeSH headings : Animals; Antisense Elements (Genetics); Brain Chemistry / drug effects; Coumestrol / pharmacology; Estradiol / pharmacology; Estrogens, Non-Steroidal / pharmacology; Female; Gene Expression / physiology; In Situ Hybridization; Isoflavones; Ovariectomy; Paraventricular Hypothalamic Nucleus / chemistry; Paraventricular Hypothalamic Nucleus / physiology; Phytoestrogens; Plant Preparations; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Septal Nuclei / chemistry; Septal Nuclei / physiology
TL;DR:
Data demonstrate that like ERalpha, ERbeta is down regulated by estrogen in a region specific manner in the rat brain, and exposure to coumestrol may modulate ERbeta-dependent processes by acting as an anti-estrogen at ERbeta.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
Employment
Updated: June 10th, 2024 12:37
NIH/NIEHS Research Triangle Park, North Carolina, US
Scientific Director
Division of Translational Toxicology
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