Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study
Foster, M. L., Bartnikas, T. B., Maresca-Fichter, H. C., Mercadante, C., Dash, M., Miller, C., & Dorman, D. C. (2018, January). NEUROTOXICOLOGY, Vol. 64, pp. 291–299.
author keywords: Manganese; Neurotoxicity; Pharmacokinetics; Metabolism
MeSH headings : Animals; Animals, Newborn; Brain / drug effects; Brain / metabolism; Female; Liver / drug effects; Liver / metabolism; Male; Manganese / toxicity; Mice, Inbred C57BL; Mice, Knockout; Motor Activity / drug effects; Pilot Projects; Tissue Distribution; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
topics (OpenAlex): Heavy Metal Exposure and Toxicity; Trace Elements in Health; Parkinson's Disease Mechanisms and Treatments
TL;DR:
The results suggest that the Parkin gene defect did not increase the susceptibility of neonatal mice to adverse health effects associated with high‐dose Mn exposure.
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