Halston Edward Deal

Works (7)

Updated: April 25th, 2025 18:07

2024 journal article

Injury-on-a-chip for modelling microvascular trauma-induced coagulation

Lab on a Chip, 25(3), 440–453.

By: H. Deal n, E. Byrnes n, S. Pandit n, A. Sheridan n, A. Brown n  & M. Daniele n 

Contributors: H. Deal n, E. Byrnes n, S. Pandit n, A. Sheridan n, A. Brown n  & M. Daniele n 

MeSH headings : Lab-On-A-Chip Devices; Blood Coagulation; Humans; Fibrin / metabolism; Fibrin / chemistry; Equipment Design; Microvessels / metabolism; Endothelium, Vascular / metabolism; Microfluidic Analytical Techniques / instrumentation
topics (OpenAlex): 3D Printing in Biomedical Research; Blood properties and coagulation; Trauma, Hemostasis, Coagulopathy, Resuscitation
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 13, 2025

2023 journal article

Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity

Cellular and Molecular Gastroenterology and Hepatology, 16(5), 823–846.

By: K. Rivera n, R. Bliton  n, J. Burclaff n , M. Czerwinski *, J. Liu *, J. Trueblood*, C. Hinesley *, K. Breau * ...

Contributors: K. Rivera n, R. Bilton  n, J. Burclaff n , M. Czerwinski *, J. Liu *, J. Trueblood*, C. Hinesley *, . al.

author keywords: Inflammatory Hypoxia; Microphysiological System; Intestinal Stem Cells; Stem Cell Priming; Oxygen Sensor; Cytokines
MeSH headings : Humans; Interleukins / metabolism; Inflammation / metabolism; Stem Cells / metabolism; Hypoxia; Oxygen / metabolism
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Mesenchymal stem cell research; Cancer Cells and Metastasis
TL;DR: A new microphysiological system (MPS) is presented to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolongedHypoxia modulates how hISC respond to inflammation-associated interleukins (ILs) and has important implications for understanding intestinal epithelial regeneration mechanisms caused by inflammatory hypoxIA. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: November 6, 2023

2023 journal article

Molecular Engineering of Cyclic Azobenzene‐Peptide Hybrid Ligands for the Purification of Human Blood Factor VIII via Photo‐Affinity Chromatography

Advanced Functional Materials, 33(14), 2213881.

By: R. Prodromou n, B. Moore n, W. Chu n, H. Deal n, A. San Miguel n , A. Brown n , M. Daniele n , V. Pozdin*, S. Menegatti n 

Contributors: R. Prodromou n, B. Moore n, W. Chu n, H. Deal n, A. Miguel n , A. Brown n , M. Daniele n , V. Pozdin*, S. Menegatti n 

author keywords: affinity ligands; azobenzene-peptide hybrids; biomolecular recognition; factor VIII; photo-affinity chromatography
topics (OpenAlex): Hemophilia Treatment and Research; Platelet Disorders and Treatments; Cancer-related gene regulation
TL;DR: The cyclic azobenzene‐peptide ligands introduced in this report demonstrate a novel route integrating gentle operational conditions in a rapid and efficient bioprocess for the purification of life‐saving biotherapeutics. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: February 20, 2023

2021 journal article

Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation

Blood Advances, 5(3), 613–627.

By: E. Mihalko n, M. Sandry n, N. Mininni n, K. Nellenbach n, H. Deal n, M. Daniele n , K. Ghadimi *, J. Levy *, A. Brown n 

Contributors: E. Mihalko n, M. Sandry n, N. Mininni n, K. Nellenbach n, H. Deal n, M. Daniele n , K. Ghadimi *, J. Levy *, A. Brown n 

MeSH headings : Disseminated Intravascular Coagulation / drug therapy; Fibrin; Humans; Microcirculation; Nanogels; Thrombosis / drug therapy
topics (OpenAlex): Blood properties and coagulation; Trauma, Hemostasis, Coagulopathy, Resuscitation; Blood Coagulation and Thrombosis Mechanisms
TL;DR: In vivo and in vivo, tPA-FSNs decreased the presentation of multiorgan microthrombi, recovered platelet counts, and improved bleeding outcomes in a DIC rodent model, demonstrating that a fibrinolytic agent loaded into fibrin-targeting nanogels could improve DIC outcomes. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: March 22, 2021

2021 article

Rheological characterization of poly-dimethyl siloxane formulations with tunable viscoelastic properties

Petet, T. J., Deal, H. E., Zhao, H. S., He, A. Y., Tang, C., & Lemmon, C. A. (2021, January 1). RSC Advances.

By: T. Petet *, H. Deal n, H. Zhao*, A. He*, C. Tang * & C. Lemmon *

topics (OpenAlex): Cellular Mechanics and Interactions; 3D Printing in Biomedical Research; biodegradable polymer synthesis and properties
TL;DR: It is demonstrated that polymers comprised of differing polydimethylsiloxane (PDMS) formulations can be generated that allow for control over both the strain-dependent storage modulus and the strain rate-dependent loss modulus, and a set of empirical equations is developed that predicts the storage and lossModulus for a given blend of PDMS formulations, allowing users to tailor substrate mechanical properties to their specific needs. (via Semantic Scholar)
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Source: Web Of Science
Added: November 15, 2021

2021 journal article

Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses

Advanced Therapeutics, 4(5).

By: S. Nandi n, E. Mihalko n, K. Nellenbach n, M. Castaneda  n, J. Schneible n, M. Harp*, H. Deal n, M. Daniele n  ...

Contributors: S. Nandi n, E. Mihalko n, K. Nellenbach n, M. Castaneda  n, J. Schneible n, M. Harp*, H. Deal n, . al.

author keywords: bleeding; Clotting; fibrin; hemostasis; microgel
topics (OpenAlex): Platelet Disorders and Treatments; Blood properties and coagulation; Periodontal Regeneration and Treatments
TL;DR: Soft microgels decorated with the peptide AHRPYAAK are found to significantly increase clot density in vitro and decrease bleeding in a rodent trauma model in vivo, indicating that FAMCYs are capable of recapitulating the platelet‐mimetic properties of previous designs while utilizing a less costly, more translational design. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 5, 2021

2020 journal article

Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies

Journal of Materials Chemistry B, 8(32), 7062–7075.

By: H. Deal n, A. Brown n  & M. Daniele n 

Contributors: H. Deal n, A. Brown n  & M. Daniele n 

MeSH headings : Animals; Cell Culture Techniques; Cell Line; Cell Movement; Cellular Microenvironment; Hemostasis / drug effects; Humans; Hydrogels / chemistry; Hydrogels / metabolism; Macrophages / metabolism; Microfluidics; Models, Animal; Skin; Stereolithography; Wound Healing / drug effects
topics (OpenAlex): 3D Printing in Biomedical Research; Planarian Biology and Electrostimulation; Cellular Mechanics and Interactions
TL;DR: This review provides a brief overview of the wound healing process and in vivo assays, and critically review the current state of microphysiological systems and supporting technologies for modelling and studying wound healing. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: September 7, 2020

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