@article{hall_uzoewulu_nizam_ishizawa_el-shaffey_ohata_2022, title={Phosphine-mediated three-component bioconjugation of amino- and azidosaccharides in ionic liquids}, volume={8}, ISSN={["1364-548X"]}, url={https://doi.org/10.1039/D2CC04013A}, DOI={10.1039/d2cc04013a}, abstractNote={Bioconjugation of carbohydrates has been a challenging task because of their chemical, functional, and structural diversities, and no single chemical modification tool can be universally applicable to all the target substrates in different environments.}, journal={CHEMICAL COMMUNICATIONS}, publisher={Royal Society of Chemistry (RSC)}, author={Hall, Yvonne D. and Uzoewulu, Chiamaka P. and Nizam, Zeinab M. and Ishizawa, Seiya and El-Shaffey, Hisham M. and Ohata, Jun}, year={2022}, month={Aug} }
 @article{pereira_walters_el-shaffey_bik_frischer_2022, title={The microbiome of the pelagic tunicate Dolioletta gegenbauri: A potential link between the grazing and microbial food web}, ISSN={["1365-294X"]}, DOI={10.1111/mec.16668}, abstractNote={Abstract}, journal={MOLECULAR ECOLOGY}, author={Pereira, Tiago J. and Walters, Tina L. and El-Shaffey, Hisham M. and Bik, Holly M. and Frischer, Marc E.}, year={2022}, month={Sep} }
 @article{el-shaffey_gross_hall_ohata_2021, title={An Ionic Liquid Medium Enables Development of a Phosphine-Mediated Amine-Azide Bioconjugation Method}, volume={143}, ISSN={["1520-5126"]}, url={https://doi.org/10.1021/jacs.1c06092}, DOI={10.1021/jacs.1c06092}, abstractNote={While a diverse set of design strategies have produced various chemical tools for biomolecule labeling in aqueous media, the development of nonaqueous, biomolecule-compatible media for bioconjugation has significantly lagged behind. In this report, we demonstrate that an aprotic ionic liquid serves as a novel reaction solvent for protein bioconjugation without noticeable loss of the biomolecule functions. The ionic liquid bioconjugation approach led to discovery of a novel triphenylphosphine-mediated amine-azide coupling reaction that forges a stable tetrazene linkage on unprotected peptides and proteins. This strategy of using untraditional media would provide untapped opportunities for expanding the scope of chemical approaches for bioconjugation.}, number={33}, journal={JOURNAL OF THE AMERICAN CHEMICAL SOCIETY}, publisher={American Chemical Society (ACS)}, author={El-Shaffey, Hisham M. and Gross, Elizabeth J. and Hall, Yvonne D. and Ohata, Jun}, year={2021}, month={Aug}, pages={12974–12979} }