Hiroko Enomoto

Works (16)

Updated: February 12th, 2026 05:06

2025 article

Distribution of fluralaner in plasma and liver in broiler breeder hens and roosters following the administration of fluralaner (Bravecto®) via medicated drinking water

Enomoto, H., Crespo, R., Neumann, L. M., Shamoun, K., Yeatts, J., & Baynes, R. E. (2025, September 26). Poultry Science, Vol. 104.

By: H. Enomoto n, R. Crespo n , L. Neumann n, K. Shamoun*, J. Yeatts n & R. Baynes n 

author keywords: Bed bug; Diethylene glycol monoethyl ether; Insecticides; Pharmacokinetics; Poultry
MeSH headings : Animals; Isoxazoles / pharmacokinetics; Isoxazoles / blood; Isoxazoles / administration & dosage; Chickens / metabolism; Chickens / blood; Liver / chemistry; Liver / metabolism; Female; Drinking Water / analysis; Insecticides / pharmacokinetics; Insecticides / administration & dosage; Insecticides / blood; Male; Administration, Oral; Tissue Distribution
topics (OpenAlex): Animal Nutrition and Physiology; Insect and Pesticide Research; Bird parasitology and diseases
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 4, 2025

2025 article

Pharmacokinetics of a Transdermal Buprenorphine Topical Solution in the Cynomolgus Macaque (Macaca fascicularis)

Santoro, E. L., Fortman, J. D., Messenger, K. M., Enomoto, H., & Halliday, L. C. (2025, December 1). Journal of the American Association for Laboratory Animal Science.

By: E. Santoro *, J. Fortman*, K. Messenger n, H. Enomoto n & L. Halliday*

topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Opioid Use Disorder Treatment; Pain Management and Opioid Use
Source: NC State University Libraries
Added: December 21, 2025

2025 article

Toltrazuril sulfone (Ponazuril) residue depletion in pig tissues and estimated withdrawal intervals

Neumann, L. M., Sheela, F., Enomoto, H., Pittman, J., & Baynes, R. E. (2025, May 27). Regulatory Toxicology and Pharmacology, Vol. 162.

By: L. Neumann n, F. Sheela n, H. Enomoto n, J. Pittman* & R. Baynes n 

author keywords: Ponazuril; Toltrazuril sulfone; Tissue residue; Withdrawal interval; Pig
MeSH headings : Animals; Triazines / pharmacokinetics; Triazines / administration & dosage; Triazines / analysis; Drug Residues / analysis; Swine; Coccidiostats / pharmacokinetics; Coccidiostats / administration & dosage; Liver / metabolism; Kidney / metabolism; Tissue Distribution; Limit of Detection; Adipose Tissue / metabolism
topics (OpenAlex): Coccidia and coccidiosis research; Veterinary medicine and infectious diseases; Helminth infection and control
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 27, 2025

2024 article

Pharmacokinetics of intranasal and intramuscular flunixin in healthy grower pigs

Wiloch, E. E., Enomoto, H., Smith, L., Baynes, R. E., & Messenger, K. M. (2024, January 11). Journal of Veterinary Pharmacology and Therapeutics, Vol. 1.

By: E. Wiloch n, H. Enomoto n, L. Smith n, R. Baynes n  & K. Messenger n

author keywords: analgesia; flunixin; intranasal; pharmacokinetics; swine
MeSH headings : Animals; Swine; Administration, Intranasal / veterinary; Injections, Intravenous / veterinary; Clonixin / pharmacokinetics; Clonixin / analogs & derivatives; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Analgesics / therapeutic use; Injections, Intramuscular / veterinary; Swine Diseases / drug therapy
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Analytical Methods in Pharmaceuticals; Receptor Mechanisms and Signaling
TL;DR: Intranasal flunixin has similar, although variable, pharmacokinetic parameters to the intramuscular route, making it a viable route of administration for use in grower swine, according to this study. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 16, 2024

2024 article

Pharmacokinetics of pradofloxacin, florfenicol, and tulathromycin and response to treatment of steers experimentally infected with Mannheimia hemolytica

Foster, D. M., Halleran, J. L., Jacob, M. E., Hempstead, S., Borst, L. B., Watanabe, T. T. N., … Papich, M. G. (2024, December 10). Journal of Veterinary Internal Medicine, Vol. 39.

By: D. Foster n , J. Halleran n, M. Jacob n, S. Hempstead n, L. Borst* , T. Watanabe *, H. Enomoto n, M. Papich n 

author keywords: antibiotics; bovine respiratory disease; fluoroquinolone
MeSH headings : Animals; Thiamphenicol / analogs & derivatives; Thiamphenicol / pharmacokinetics; Thiamphenicol / therapeutic use; Cattle; Disaccharides / pharmacokinetics; Disaccharides / therapeutic use; Heterocyclic Compounds / pharmacokinetics; Heterocyclic Compounds / therapeutic use; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Male; Mannheimia haemolytica / drug effects; Fluoroquinolones / pharmacokinetics; Fluoroquinolones / therapeutic use; Cattle Diseases / drug therapy; Pasteurella Infections / drug therapy; Pasteurella Infections / veterinary; Macrolides
topics (OpenAlex): Microbial infections and disease research; Veterinary medicine and infectious diseases; Animal health and immunology
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2024

2024 article

Residue, distribution and depletion of fluralaner in egg following a single intravenous and transdermal administration in healthy shaver hens: fluralaner residue in egg

Enomoto, H., Elliot, B. A., Petritz, O. A., Crespo, R., Yeatts, J., Sheela, F. F., … Baynes, R. E. (2024, May 14). Poultry Science, Vol. 103.

By: H. Enomoto n, B. Elliot n, O. Petritz n , R. Crespo n , J. Yeatts n, F. Sheela n, I. Fricke n, A. Singleton n, A. Thomson n, R. Baynes n 

author keywords: fluralaner; egg; residue; UPLC/MS/MS; drug withdrawal interval
MeSH headings : Animals; Chickens; Isoxazoles / administration & dosage; Isoxazoles / pharmacokinetics; Female; Drug Residues / chemistry; Drug Residues / analysis; Administration, Cutaneous; Ovum / chemistry; Eggs / analysis; Acaricides / administration & dosage; Acaricides / pharmacokinetics; Injections, Intravenous / veterinary; Pesticide Residues / analysis
topics (OpenAlex): Insect and Pesticide Research; Insect-Plant Interactions and Control; Entomopathogenic Microorganisms in Pest Control
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 1, 2024

2023 article

Pharmacokinetics and Safety of Sulfamethoxazole-Trimethoprim After Oral Administration of Single and Multiple Doses to Rhode Island Red Chickens (Gallus gallus domesticus)

Petritz, O. A., Enomoto, H., Meyer, E. G., Thomson, A., Baynes, R. E., & Flammer, K. (2023, June 21). Journal of Avian Medicine and Surgery, Vol. 37, pp. 1–12.

By: O. Petritz n , H. Enomoto n, E. Meyer  n, A. Thomson n, R. Baynes n  & K. Flammer n

author keywords: pharmacokinetics; sulfamethoxazole-trimethoprim; safety; avian; chicken; Gallus gallus domesticus
MeSH headings : Animals; Female; Chickens; Rhode Island; Drug Combinations; Trimethoprim, Sulfamethoxazole Drug Combination / adverse effects; Administration, Oral
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Pneumocystis jirovecii pneumonia detection and treatment; Analytical Methods in Pharmaceuticals
TL;DR: Sulfamethoxazole-trimethoprim-TMP maintained therapeutic plasma concentrations at or exceeding the minimum inhibitory concentration breakpoint of Enterobacteriaceae for 72 and 24 hours for TMP and SMZ, respectively, without evidence of adverse effects or drug accumulation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 30, 2023

2023 article

Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, Cimex lectularius, in poultry facilities

González-Morales, M. A., Thomson, A. E., Yeatts, J., Enomoto, H., Haija, A., Santangelo, R. G., … Baynes, R. (2023, September 21). Parasites & Vectors, Vol. 16.

By: M. González-Morales  n, A. Thomson n, J. Yeatts n, H. Enomoto n, A. Haija n, R. Santangelo n, O. Petritz n , R. Crespo n , C. Schal n , R. Baynes n 

author keywords: Cimex; Bed bugs; Fluralaner; Pharmacokinetics; Poultry; Ectoparasites
MeSH headings : Animals; Female; Poultry; Chickens; Bedbugs; Isoxazoles
topics (OpenAlex): Dermatological diseases and infestations; Insect and Pesticide Research; Insects and Parasite Interactions
TL;DR: Fluralaner appears to be a promising candidate for bed bug control in poultry farms, with a treatment effect lasting at least 28 days, and quantifiable in the hens’ plasma for at least28 days post-treatment. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 22, 2023

2023 article

Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens

Elliot, B. A., Enomoto, H., Petritz, O., Crespo, R., Yeatts, J., Fricke, I., … Baynes, R. E. (2023, December 9). Poultry Science, Vol. 103.

By: B. Elliot n, H. Enomoto n, O. Petritz n , R. Crespo n , J. Yeatts n, I. Fricke n, A. Singleton n, A. Thomson n, R. Baynes n 

author keywords: fluralaner; LC/MS; plasma; white shaver hen; pharmacokinetics
MeSH headings : Animals; Female; Cats; Dogs; Chickens; Cat Diseases; Dog Diseases; Biological Availability; Isoxazoles
topics (OpenAlex): Insect and Pesticide Research; Dermatological diseases and infestations; Insect-Plant Interactions and Control
TL;DR: Investigation of the plasma fluralaner pharmacokinetic profile of intravenous and transdermal routes and apparent bioavailability of fluralaner administered trans-dermally in healthy shaver hens found it important to understand the pharmacokinetic profile could be useful in determining the appropriate treatment strategy. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024

2022 article

Ceftazidime pharmacokinetics in dogs after intravenous injection and delivered with the RxActuator Mini‐Infuser infusion pump

Papich, M. G., Madsen, M., Messenger, K., & Enomoto, H. (2022, May 6). Journal of Veterinary Emergency and Critical Care, Vol. 5.

By: M. Papich n , M. Madsen n, K. Messenger n & H. Enomoto n

author keywords: antimicrobial; canine; cephalosporin; half-life; mean inhibitory concentration
MeSH headings : Animals; Ceftazidime / pharmacokinetics; Dogs; Humans; Infusion Pumps / veterinary; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Antibiotic Resistance in Bacteria; Pneumonia and Respiratory Infections
TL;DR: This study demonstrated the successful application of the RxActuator Mini-Infuser wearable SC constant rate infusion pump for delivering an antimicrobial needed for serious, and sometimes resistant, infections in dogs. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 7, 2022

2022 article

Control of ticks on horses using abamectin‐impregnated ear tags. A pharmacokinetic and pharmacodynamic study

Werners, A., Karasek, I., Butler, C., Yeatts, J., Enomoto, H., & Baynes, R. (2022, June 28). Journal of Veterinary Pharmacology and Therapeutics, Vol. 6.

By: A. Werners *, I. Karasek*, C. Butler*, J. Yeatts n, H. Enomoto n & R. Baynes n 

author keywords: abamectin; horse; pharmacokinetics; skin; ticks
MeSH headings : Animals; Cattle; Cattle Diseases; Ear, External; Horse Diseases / drug therapy; Horse Diseases / prevention & control; Horses; Ivermectin / analogs & derivatives; Tick Infestations / drug therapy; Tick Infestations / prevention & control; Tick Infestations / veterinary; Ticks
topics (OpenAlex): Vector-borne infectious diseases; Dermatological diseases and infestations; Insect and Pesticide Research
TL;DR: A practical and affordable prevention of tick infestation by using abamectin-impregnated cattle ear tags affixed to a safety collar is described and results show that abamECTin distributes across horse skin from the site of application and its associated effectiveness in reducing the tick burden. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 5, 2022

2022 article

Pharmacokinetics of intravenous, oral transmucosal, and intranasal buprenorphine in healthy male dogs

Enomoto, H., Love, L., Madsen, M., Wallace, A., & Messenger, K. M. (2022, April 21). Journal of Veterinary Pharmacology and Therapeutics, Vol. 7.

By: H. Enomoto n, L. Love n , M. Madsen n, A. Wallace n & K. Messenger n

author keywords: buprenorphine; dog; intranasal; oral transmucosal; pharmacokinetics; Simbadol (TM)
MeSH headings : Administration, Intravenous / veterinary; Administration, Mucosal; Administration, Oral; Analgesics; Animals; Biological Availability; Buprenorphine / pharmacokinetics; Cross-Over Studies; Dogs; Male
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Opioid Use Disorder Treatment; Pain Mechanisms and Treatments
TL;DR: Intranasal and OTM routes of administration of concentrated buprenorphine in dogs may allow for the provision of analgesic care at home. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 2, 2022

2022 article

Preliminary evaluation of the effects of grapiprant compared with carprofen on acute pain and inflammation following ovariohysterectomy in dogs

Southern, B. L., Long, S. M., Barnes, D. N., Enomoto, H., & Messenger, K. M. (2022, June 7). American Journal of Veterinary Research.

By: B. Southern n, S. Long n, D. Barnes n, H. Enomoto n & K. Messenger n

MeSH headings : Acute Pain / drug therapy; Acute Pain / veterinary; Animals; Carbazoles / therapeutic use; Dinoprostone; Dog Diseases / drug therapy; Dogs; Female; Hysterectomy / veterinary; Imidazoles; Inflammation / drug therapy; Inflammation / veterinary; Ovariectomy / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Pyridines; Sulfonylurea Compounds
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research; Coccidia and coccidiosis research
TL;DR: Results of this preliminary study suggested both carprofen and grapiprant may be effective for postoperative pain following OVH in dogs; however, additional studies are warranted to determine grapipant's effectiveness in a larger and more diverse population of dogs. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 27, 2022

2021 article

Effects of housing environment on oral absorption of acetaminophen in healthy Beagles

Madsen, M., Enomoto, H., Messenger, K., & Papich, M. G. (2021, November 12). American Journal of Veterinary Research, Vol. 1.

By: M. Madsen n, H. Enomoto n, K. Messenger n & M. Papich n 

MeSH headings : Acetaminophen; Animals; Cross-Over Studies; Dogs; Gastric Emptying; Housing
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Drug-Induced Hepatotoxicity and Protection; Pain Mechanisms and Treatments
TL;DR: It is suggested that in dogs, housing environment (normal environment vs a cage in an unfamiliar environment) did not significantly affect oral absorption and, by extension, gastric emptying of acetaminophen. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022

2021 article

Egg residue and depletion in Rhode Island Red hens (Gallus gallus domesticus) following multiple oral doses of trimethoprim-sulfamethoxazole

Enomoto, H., Petritz, O. A., Thomson, A. E., Flammer, K., Ferdous, F., Meyer, E., … Baynes, R. E. (2021, May 10). Regulatory Toxicology and Pharmacology, Vol. 123, p. 104941.

By: H. Enomoto n, O. Petritz n , A. Thomson n, K. Flammer n, F. Ferdous n, E. Meyer *, L. Tell *, R. Baynes n 

author keywords: Sulfamethoxazole; Trimethoprim; WDI; LC-MS; Egg; Hen
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / toxicity; Chickens; Drug Combinations; Egg Yolk; Eggs / analysis; Female; Humans; Mass Spectrometry; Rhode Island; Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage; Trimethoprim, Sulfamethoxazole Drug Combination / analysis; Trimethoprim, Sulfamethoxazole Drug Combination / toxicity
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Pharmaceutical and Antibiotic Environmental Impacts; Drug Transport and Resistance Mechanisms
TL;DR: Evaluated the drug elimination parameters in egg components and whole egg to better estimate the withdrawal interval of sulfamethoxazole and trimethoprim following oral administration for 7 days at a purposed dosage regimen. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 12, 2021

2021 article

In vivo assessment of a delayed release formulation of larazotide acetate indicated for celiac disease using a porcine model

Enomoto, H., Yeatts, J., Carbajal, L., Krishnan, B. R., Madan, J. P., Laumas, S., … Messenger, K. M. (2021, April 12). PLoS ONE, Vol. 16.

By: H. Enomoto n, J. Yeatts n, L. Carbajal n, B. Krishnan, J. Madan, S. Laumas, A. Blikslager n , K. Messenger n

MeSH headings : Administration, Oral; Animals; Celiac Disease / drug therapy; Drug Liberation; Duodenum / metabolism; Jejunum / metabolism; Oligopeptides / administration & dosage; Oligopeptides / pharmacokinetics; Oligopeptides / therapeutic use; Swine
topics (OpenAlex): Celiac Disease Research and Management; Helicobacter pylori-related gastroenterology studies; Microscopic Colitis
TL;DR: The data shows that LA is available in detectable concentrations at the site of CeD, with a sensitive liquid chromatography/tandem mass spectrometry method developed to quantify LA concentrations in porcine intestinal fluid samples. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

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