Hiroki Kittaka

Works (3)

Updated: July 5th, 2023 15:30

2020 journal article

Differential contribution of sensory transient receptor potential channels in response to the bioactive lipid sphingosine-1-phosphate

MOLECULAR PAIN, 16.

By: H. Kittaka n, J. DeBrecht n & S. Mishra n

author keywords: Itch; pain; sphingosine 1-phosphate; TRPA1; TRPV1
MeSH headings : Animals; Behavior, Animal; Calcium / metabolism; Cells, Cultured; Female; Gene Expression Regulation; Lysophospholipids / chemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pruritus / drug therapy; Sensory Receptor Cells / metabolism; Sphingosine / analogs & derivatives; Sphingosine / chemistry; TRPA1 Cation Channel / metabolism; TRPV Cation Channels / metabolism
TL;DR: It is revealed that S1P induces both pain and itch in vivo and that these responses are partially dependent upon the TRPV1, but not TRPA1 channels. (via Semantic Scholar)
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Source: Web Of Science
Added: March 16, 2020

2019 journal article

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (151).

By: Y. Yamanoi*, H. Kittaka n & M. Tominaga *

author keywords: Neuroscience; Issue 151; scratching; itch; pain; behavior; histamine; capsaicin
MeSH headings : Animals; Antipruritics / administration & dosage; Behavior, Animal / drug effects; Capsaicin / administration & dosage; Cheek; Disease Models, Animal; Injections; Lysophospholipids / toxicity; Male; Mice; Mice, Inbred C57BL; Pain / chemically induced; Pain / drug therapy; Pain / pathology; Pain / psychology; Pruritus / chemically induced; Pruritus / drug therapy; Pruritus / pathology; Pruritus / psychology
TL;DR: Investigation into the effects of LPA in a mouse cheek injection model showed that LPA only induced scratching, but not wiping behaviors, which indicates that L PA acts as a pruritogen similarly in mice and humans, and demonstrates the utility of a cheek injections model for itch research. (via Semantic Scholar)
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Added: November 18, 2019

2019 journal article

Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients

CANCER MEDICINE, 8(3), 1110–1123.

By: G. Panigrahi *, P. Praharaj *, H. Kittaka n, A. Mridha *, O. Black*, R. Singh *, R. Mercer*, A. Bokhoven * ...

author keywords: biomarker; exosomes; health disparity; inflammation; prostate cancer
MeSH headings : Black or African American; Biomarkers, Tumor; Biopsy; Calcium / metabolism; Cell Line, Tumor; Chromatography, Liquid; Exosomes / metabolism; Exosomes / ultrastructure; Filamins / metabolism; Healthcare Disparities; Humans; Immunohistochemistry; Inflammation Mediators; Macrophages / metabolism; Male; Molecular Imaging; Neurons / metabolism; Phenotype; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / metabolism; Proteome; Proteomics / methods; Tandem Mass Spectrometry; White People
TL;DR: Results support the usefulness of serum exosomes to noninvasively detect inflammatory phenotype and to discover novel biomarkers associated with PCa in African American men. (via Semantic Scholar)
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Source: Web Of Science
Added: April 9, 2019

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