Works (3)
Updated: July 5th, 2023 15:30
2020 journal article
Differential contribution of sensory transient receptor potential channels in response to the bioactive lipid sphingosine-1-phosphate
MOLECULAR PAIN, 16.
author keywords: Itch; pain; sphingosine 1-phosphate; TRPA1; TRPV1
MeSH headings : Animals; Behavior, Animal; Calcium / metabolism; Cells, Cultured; Female; Gene Expression Regulation; Lysophospholipids / chemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pruritus / drug therapy; Sensory Receptor Cells / metabolism; Sphingosine / analogs & derivatives; Sphingosine / chemistry; TRPA1 Cation Channel / metabolism; TRPV Cation Channels / metabolism
TL;DR:
It is revealed that S1P induces both pain and itch in vivo and that these responses are partially dependent upon the TRPV1, but not TRPA1 channels.
(via Semantic Scholar)
journals.sagepub.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 16, 2020
2019 journal article
Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (151).
author keywords: Neuroscience; Issue 151; scratching; itch; pain; behavior; histamine; capsaicin
MeSH headings : Animals; Antipruritics / administration & dosage; Behavior, Animal / drug effects; Capsaicin / administration & dosage; Cheek; Disease Models, Animal; Injections; Lysophospholipids / toxicity; Male; Mice; Mice, Inbred C57BL; Pain / chemically induced; Pain / drug therapy; Pain / pathology; Pain / psychology; Pruritus / chemically induced; Pruritus / drug therapy; Pruritus / pathology; Pruritus / psychology
TL;DR:
Investigation into the effects of LPA in a mouse cheek injection model showed that LPA only induced scratching, but not wiping behaviors, which indicates that L PA acts as a pruritogen similarly in mice and humans, and demonstrates the utility of a cheek injections model for itch research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 18, 2019
2019 journal article
Exosome proteomic analyses identify inflammatory phenotype and novel biomarkers in African American prostate cancer patients
CANCER MEDICINE, 8(3), 1110–1123.
author keywords: biomarker; exosomes; health disparity; inflammation; prostate cancer
MeSH headings : Black or African American; Biomarkers, Tumor; Biopsy; Calcium / metabolism; Cell Line, Tumor; Chromatography, Liquid; Exosomes / metabolism; Exosomes / ultrastructure; Filamins / metabolism; Healthcare Disparities; Humans; Immunohistochemistry; Inflammation Mediators; Macrophages / metabolism; Male; Molecular Imaging; Neurons / metabolism; Phenotype; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / metabolism; Proteome; Proteomics / methods; Tandem Mass Spectrometry; White People
TL;DR:
Results support the usefulness of serum exosomes to noninvasively detect inflammatory phenotype and to discover novel biomarkers associated with PCa in African American men.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 9, 2019
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