Works (6)

Updated: July 12th, 2023 21:19

2014 journal article

Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats


By: H. Patisaul n, N. Mabrey n, H. Adewale n & A. Sullivan n

author keywords: Phytoestrogens; Genistein; Endocrine disruptors; Ovary; Development
MeSH headings : Animals; Benzhydryl Compounds / adverse effects; Diet / adverse effects; Endocrine Disruptors / adverse effects; Female; Ovary / drug effects; Ovary / pathology; Phenols / adverse effects; Polycystic Ovary Syndrome / chemically induced; Polycystic Ovary Syndrome / pathology; Pregnancy; Rats; Rats, Wistar; Soy Foods / adverse effects; Testosterone / blood
TL;DR: Lifetime exposure to a soy diet, containing endocrine active phytoestrogens, but not developmental exposure to the endocrine disrupting monomer bisphenol A (BPA), can induce key features of PCOS in the rat, results which support the hypothesis that hormonally active diets may contribute to risk when consumed throughout gestation and post-natal life. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Anxiogenic Effects of Developmental Bisphenol A Exposure Are Associated with Gene Expression Changes in the Juvenile Rat Amygdala and Mitigated by Soy

PLOS ONE, 7(9).

By: H. Patisaul n, A. Sullivan n, M. Radford n, D. Walker*, H. Adewale n, B. Winnik*, J. Coughlin*, B. Buckley*, A. Gore*

MeSH headings : Amygdala / drug effects; Animals; Anxiety / chemically induced; Anxiety / etiology; Benzhydryl Compounds / adverse effects; Estrogen Receptor beta / metabolism; Female; Gene Expression Profiling; Genistein / pharmacology; Maternal Exposure; Phenols / adverse effects; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; Receptors, Melanocortin / metabolism; Sex Characteristics; Soybeans / drug effects; Water / chemistry
TL;DR: Results show that behavioral impacts of BPA can manifest during adolescence, but wane in adulthood, and may be mitigated by diet, and reveal that, because ERβ and melanocortin receptors are crucial to their function, oxytocin/vasopressin signaling pathways, which have been linked to human affective disorders, may underlie these behavioral outcomes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat

NEUROTOXICOLOGY, 32(1), 38–49.

By: H. Adewale n, K. Todd n, J. Mickens n & H. Patisaul n

author keywords: Xenoestrogen; Endocrine disruption; Brain; Sexual differentiation; Development; Estrogen receptor; Neuroendocrine
MeSH headings : Age Factors; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / growth & development; Benzhydryl Compounds; Body Weight / drug effects; Body Weight / physiology; Female; Phenols / toxicity; Preoptic Area / drug effects; Preoptic Area / growth & development; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology; Ventromedial Hypothalamic Nucleus / drug effects; Ventromedial Hypothalamic Nucleus / growth & development
TL;DR: The results of this and a prior study indicate that the impact of neonatal BPA Exposure within the female rat hypothalamus is region specific and support the hypothesis that developmental BPA exposure may adversely affect reproductive development in females. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Impact of neonatal exposure to the ERα agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats

NeuroToxicology, 30(3), 350–357.

By: H. Patisaul n, K. Todd n, J. Mickens n & H. Adewale n

author keywords: Bisphenol; Phytoestrogens; Soy; Genistein; Equal; Gonadotropins; Development; Disruption; Estrogen; Estrogen receptor; GnRH; KISS
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Female; Hypothalamus / anatomy & histology; Kisspeptins; Male; Nerve Fibers / drug effects; Nerve Fibers / metabolism; Ovariectomy; Phenols / pharmacology; Phytoestrogens / pharmacology; Progesterone / pharmacology; Proteins / metabolism; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Sex Characteristics
TL;DR: The results suggest that the organization of hypothalamic KISS fibers may be vulnerable to disruption by EDC exposure and that females might be more sensitive than males. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin-Releasing Hormone Neurons


By: H. Adewale n, W. Jefferson*, R. Newbold* & H. Patisaul n

author keywords: AVPV; corpora lutea; development; disruption; endocrine disruptors; ER alpha; ESR1; estradiol; estradiol receptor; estrogen; estrogen receptor; GnRH; gonad; hypothalamus; lordosis; neuroendocrinology; ovary; PPT; puberty
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Dose-Response Relationship, Drug; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / toxicity; Estrous Cycle / drug effects; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Neuroendocrine Cells / drug effects; Ovary / drug effects; Ovary / pathology; Phenols / administration & dosage; Phenols / toxicity; Proto-Oncogene Proteins c-fos / metabolism; Rats; Rats, Long-Evans; Sexual Behavior, Animal / drug effects; Sexual Maturation / drug effects
TL;DR: The data suggest that BPA disrupts ovarian development but not the ability of GnRH neurons to respond to steroid-positive feedback. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats

HORMONES AND BEHAVIOR, 55(2), 319–328.

By: H. Patisaul n, K. Burke, R. Hinkle, H. Adewale* & D. Shea*

Contributors: H. Patisaul n, K. Burke, R. Hinkle, H. Adewale* & D. Shea*

author keywords: DPN; PPT; Estrogen; Soy isoflavones; Testosterone; Anxiety; Endocrine active compound; Resveratrol; Equol; Plus maze; ER beta; Estrogen receptor beta
MeSH headings : Analysis of Variance; Animals; Anti-Anxiety Agents / administration & dosage; Anxiety / drug therapy; Behavior, Animal / drug effects; Equol; Estrogen Receptor alpha / agonists; Isoflavones / administration & dosage; Male; Nitriles / administration & dosage; Nitriles / blood; Phenols; Phytoestrogens / administration & dosage; Propionates / administration & dosage; Propionates / blood; Pyrazoles / administration & dosage; Rats; Rats, Long-Evans; Rats, Wistar; Resveratrol; Stilbenes / administration & dosage; Testosterone / blood
TL;DR: It is determined that DPN can be successfully administered either orally or by subcutaneous injection, although plasma DPN levels are significantly lower if given orally, and the efficacy of ERbeta agonists may depend on gonadal status, therefore the therapeutic potential of ER beta selective agonists to treat mood disorders may be limited. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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