Works (4)
Updated: July 5th, 2023 15:32
2020 journal article
Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis
NANO RESEARCH, 13(8), 2197–2202.
author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
TL;DR:
A targeted and controlled release method that triggers HSC apoptosis and reverses the liver fibrosis is provided the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 29, 2020
2020 journal article
Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs
THERANOSTICS, 10(8), 3474–3487.
author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
TL;DR:
It is demonstrated that the exosomes' ability to target the parent cancer is a phenomenon that opens up new ways to devise targeted therapies to deliver anti-tumor drugs.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020
2019 journal article
Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells
NANO LETTERS, 19(3), 1883–1891.
author keywords: Myocardium infarction; platelets; endogenous stem cells; antibodies
MeSH headings : Animals; Antigens, CD34 / immunology; Blood Platelets / chemistry; Blood Platelets / immunology; Cell- and Tissue-Based Therapy; Disease Models, Animal; Heart Injuries / genetics; Heart Injuries / pathology; Heart Injuries / therapy; Humans; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / immunology; Myocardium / pathology; Stem Cells / immunology; Stem Cells / metabolism
TL;DR:
Taking advantage of the natural infarct-homing ability of platelets, CD34 antibody-linked platelets (P-CD34) are engineered to capture circulating CD34-positive endogenous stem cells and direct them to the injured heart for effective heart repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019
2018 journal article
Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury
ADVANCED FUNCTIONAL MATERIALS, 29(4).
author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
TL;DR:
A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019