Hiroyuki Mochizuki
Assistant Professor of Veterinary Clinical Pathology at North Carolina State University
Works (37)
Updated: November 21st, 2024 09:25
2024 journal article
Elevated serum gamma‐glutamyltransferase activity and immunohistochemistry in two dogs with renal carcinoma
Veterinary Clinical Pathology.
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: August 1, 2024
2024 article
What is your diagnosis? Blood smear from a Corolla wild horse stallion
Benedict, W., Parsley, A., & Mochizuki, H. (2024, February 1). VETERINARY CLINICAL PATHOLOGY, Vol. 2.
author keywords: Equine; microfilaria; Setaria
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 2, 2024
2023 article
Eosinophilic cavitary effusions in cats: 48 cases (2010-2020)
Wheatley, M. A., Stowe, D. M., & Mochizuki, H. (2023, October 3). VETERINARY CLINICAL PATHOLOGY, Vol. 10.
author keywords: carcinoma; eosinophil; eosinophilia; feline; lymphoma; neoplastic effusion
TL;DR:
The findings suggest an eosinophil differential of 5%-9% is seen with similar etiologies considered for classically defined eosInophilic effusions, which is consistent with the current literature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 23, 2023
2023 journal article
Hematologic Abnormalities and Diseases Associated with Moderate-to-Marked Basophilia in a Large Cohort of Dogs
Veterinary Sciences.
TL;DR:
Interestingly, dogs with marked basophilia were more likely to be diagnosed with neoplasia and had fewer inflammatory conditions than those with moderate basophilia, and when dogs with moderate-to-marked basophilia displayed concurrent eosinophilia, they were diagnosed more often with inflammatory conditions and less often with neoplasia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: January 28, 2024
2022 article
Editorial: Comparative Oncology-Advances in Veterinary Molecular Oncology
Meichner, K., McCleary-Wheeler, A. L., Mochizuki, H., & Stokol, T. (2022, January 12). FRONTIERS IN VETERINARY SCIENCE, Vol. 8.
author keywords: cancer; genetics; pathogenesis; prognosis; targeted therapeutics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022
2021 journal article
A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation
FRONTIERS IN ONCOLOGY, 11.
author keywords: angiopellosis; circulating tumor cell cluster; tumor cell extravasation; cancer exodus hypothesis; metastasis; osteosarcoma
TL;DR:
Together, the results provide a novel experimental framework to study discrete steps in the metastatic process and identify the versican/ECM network dysregulation as a potential contributor to osteosarcoma circulating tumor cell metastasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 journal article
Hematologic and clinical characteristics of dogs with circulating macrophage-like cells
VETERINARY CLINICAL PATHOLOGY, 50(1), 37–44.
author keywords: canine; hepatic lymphoma; histiocytes; histiocytic sarcoma; monocyte; pancytopenia
MeSH headings : Animals; Blood Cell Count / veterinary; Dog Diseases / diagnosis; Dogs; Histiocytic Sarcoma / veterinary; Macrophages; Retrospective Studies
TL;DR:
The hemograms and diagnoses of dogs with ML cells suggest that severe inflammatory conditions or histiocytic and non-histiocytical neoplasia are common causes for circulating ML cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 29, 2021
2021 journal article
Lung sound analysis in infants with risk factors for asthma development
Health Science Reports.
TL;DR:
Using a lung sound analysis, the prognosis of asthma was investigated in infants with risk factors for asthma development by a long‐term observation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 29, 2023
2021 journal article
What is your diagnosis? Dermal mass in a dog
Veterinary Clinical Pathology, 51(1), 161–163.
author keywords: ALP cytochemical stain; Canine; Cutaneous; Metastasis; Osteosarcoma
MeSH headings : Animals; Bone Neoplasms / veterinary; Dog Diseases / diagnosis; Dogs; Osteosarcoma / diagnosis; Osteosarcoma / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: November 5, 2021
2021 journal article
What is your diagnosis? Mass in the abdomen of a cat
Veterinary Clinical Pathology, 50(3), 465–467.
MeSH headings : Abdomen; Abdominal Cavity; Animals; Cat Diseases / diagnosis; Cats; Diagnosis, Differential
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: July 27, 2021
2020 article
What is your diagnosis? Transtracheal wash in a horse
Mochizuki, H., Eaton, E., Breuhaus, B., & Stowe, D. M. (2020, December). VETERINARY CLINICAL PATHOLOGY, Vol. 49, pp. 675–677.
MeSH headings : Animals; Horses; Trachea
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 9, 2020
2019 journal article
Development of canine X-chromosome inactivation pattern analysis for the detection of cell clonality by incorporating the examination of the SLIT and NTRK-like family member 4 (SLITRK4) gene
RESEARCH IN VETERINARY SCIENCE, 125, 170–175.
author keywords: Androgen receptor; Clonality; Dog; SLITRK4; XCIP
MeSH headings : Alleles; Animals; Cell Lineage; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Female; Gene Expression Regulation; Heterozygote; Male; Membrane Proteins / genetics; Membrane Proteins / metabolism; Neoplasms / genetics; Neoplasms / metabolism; Receptors, Androgen / genetics; Receptors, Androgen / metabolism; X Chromosome / physiology; X Chromosome Inactivation
TL;DR:
The availability of canine XCIP analysis was improved by incorporating the examination of the SLITRK4 gene, providing a highly useful laboratory examination system for the detection of the clonality of various cell/tissue samples in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 30, 2019
2019 journal article
Lack of influence by endosymbiont Wolbachia on virus titer in the common bed bug, Cimex lectularius
Parasites & Vectors, 12(1).
author keywords: Cimex lectularius; Wolbachia; Endosymbiont; Cimicidae; Virus suppression; ssRNA
MeSH headings : Animals; Bedbugs / microbiology; Bedbugs / virology; Calicivirus, Feline / growth & development; Calicivirus, Feline / isolation & purification; Microbial Interactions; Viral Load; Wolbachia / growth & development
TL;DR:
It is suggested that other mechanisms are involved in virus suppression within bed bugs, independent of the influence of Wolbachia, and the need for future research is underscore.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 30, 2019
2019 journal article
What is your diagnosis? Lymphocytes engulfing erythrocytes in a cat
Veterinary Clinical Pathology, 48(4), 768–770.
author keywords: cell cannibalism; chronic lymphocytic leukemia; erythrophagia; feline; lymphoma
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / pathology; Cats; Female; Leukemia, Lymphoid / diagnosis; Leukemia, Lymphoid / pathology; Leukemia, Lymphoid / veterinary; Lymphocytes
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 21, 2020
2018 journal article
Prognostic significance of hypermethylation of death-associated protein kinase (DAPK) gene CpG island in dogs with high-grade B-cell lymphoma.
Veterinary and Comparative Oncology, 3.
MeSH headings : Animals; CpG Islands / genetics; DNA Methylation / genetics; Death-Associated Protein Kinases / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / mortality; Dogs; Female; Lymphoma, B-Cell / diagnosis; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / mortality; Lymphoma, B-Cell / veterinary; Male; Prognosis; Retrospective Studies; Survival Analysis
TL;DR:
Overall, hypermethylation of the DAPK CpG island was a negative prognostic factor in canine high-grade B-cell lymphoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2017 journal article
Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade
CHROMOSOME RESEARCH, 25(2), 129–143.
author keywords: Cancer; Comparative genomic hybridization; Digital PCR; Dog; Mastocytosis; Pug
MeSH headings : Animals; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dogs; Genome / genetics; Mastocytosis, Cutaneous / diagnosis; Mastocytosis, Cutaneous / genetics; Mastocytosis, Cutaneous / pathology; Mutation; Predictive Value of Tests; Proto-Oncogene Proteins c-kit / genetics; Sensitivity and Specificity
TL;DR:
Characterization of genomic alterations in canine MCTs may identify genomic regions and/or genes responsible for their development and progression, facilitating the discovery of new therapeutic targets and improved clinical management of this heterogeneous cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Association of breed and histopathological grade in canine mast cell tumours
VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 829–839.
Contributors: n , A. Motsinger-Reif n, C. Bettini, S. Moroff & M. Breen n
author keywords: Boxer; dog; epidemiology; genetics; MCT; Pug
MeSH headings : Age Factors; Animals; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Female; Male; Mastocytosis, Cutaneous / etiology; Mastocytosis, Cutaneous / pathology; Mastocytosis, Cutaneous / veterinary; Retrospective Studies; Risk Factors; Sex Factors; Skin Neoplasms / etiology; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Species Specificity
TL;DR:
The data indicate that the proportion of high-grade tumours increases with advancing age, and that male and intact dogs have increased odds of developing high- grade tumours, and a genetic association for the development ofhigh-grade MCTs is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Genetic and epigenetic aberrations of p16 in feline primary neoplastic diseases and tumor cell lines of lymphoid and non-lymphoid origins
The Veterinary Journal, 219, 27–33.
MeSH headings : Animals; Cat Diseases / etiology; Cat Diseases / genetics; Cat Diseases / metabolism; Cats; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Epigenesis, Genetic; Lymphoproliferative Disorders / etiology; Lymphoproliferative Disorders / genetics; Lymphoproliferative Disorders / metabolism; Lymphoproliferative Disorders / veterinary
TL;DR:
The data indicate that molecular alterations of the p16 locus may be involved in the development of specific types of feline cancer, and warrant further studies to evaluate the clinical value of this evolutionarily-conserved molecular alteration in feline cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2016 journal article
Sequence analysis of RAS and RAF mutation hot spots in canine carcinoma
VETERINARY AND COMPARATIVE ONCOLOGY, 15(4), 1598–1605.
Contributors: n & M. Breen n
author keywords: bladder; cancer; dog; prostate; squamous cell carcinoma; transitional cell carcinoma
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Genes, ras / genetics; Mutation / genetics; Neoplasms / genetics; Neoplasms / veterinary; Proto-Oncogene Proteins B-raf / genetics; Sequence Analysis, DNA / veterinary
TL;DR:
Evaluated the mutational status of three RAS genes (HRAS, KRAS and NRAS) in four types of canine carcinoma with and without the BRAF V595E mutation, indicating similar functional consequence of these mutations (e.g. MAPK pathway activation).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
BRAF Mutations in Canine Cancers
PLOS ONE, 10(6).
Contributors: n , K. Kennedy n, S. Shapiro n & M. Breen n
MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Dogs; Exons / genetics; Female; Genetic Predisposition to Disease; Humans; Male; Molecular Sequence Data; Mutation / genetics; Neoplasms / genetics; Neoplasms / veterinary; Proto-Oncogene Proteins B-raf / chemistry; Proto-Oncogene Proteins B-raf / genetics; Sequence Analysis, DNA
TL;DR:
The evolutional conservation of the BRAF V600E mutation highlights the importance of MAPK pathway activation in neoplasia and may offer opportunity for molecular diagnostics and targeted therapeutics for dogs bearing BRAF-mutated cancers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Construction of a multicolor GeneScan analytical system to detect clonal rearrangements of immunoglobulin and T cell receptor genes in canine lymphoid tumors
Veterinary Immunology and Immunopathology, 165(1-2), 81–87.
Contributors: Y. Goto-Koshino *, * , M. Sato *, K. Nakashima *, S. Hiyoshi*, A. Fujiwara-Igarashi *, S. Maeda *, K. Nakamura*
MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / immunology; Dogs / genetics; Gene Rearrangement / genetics; Genes, T-Cell Receptor gamma / genetics; Immunoglobulin Heavy Chains / genetics; Immunoglobulins / genetics; Lymphoma / genetics; Lymphoma / immunology; Lymphoma / veterinary; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Receptors, Antigen, T-Cell / genetics
TL;DR:
A multicolor GeneScan analytical system to improve the sensitivity and resolution of the clonality analysis of antigen receptor gene rearrangements in dogs and may prove to be helpful for the diagnosis of lymphoid tumors in dogs.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2015 journal article
Detection of BRAF Mutation in Urine DNA as a Molecular Diagnostic for Canine Urothelial and Prostatic Carcinoma
PLOS ONE, 10(12).
Contributors: n , S. Shapiro n & M. Breen n
MeSH headings : Animals; Biomarkers, Tumor / urine; DNA / urine; Dogs; Male; Mutation; Polymerase Chain Reaction; Prostatic Neoplasms / diagnosis; Prostatic Neoplasms / urine; Proto-Oncogene Proteins B-raf / genetics; Urinary Bladder Neoplasms / diagnosis; Urinary Bladder Neoplasms / urine
TL;DR:
It is shown that ddPCR is a sensitive molecular technique with the potential to facilitate accurate and non-invasive means of canine UC and PC diagnosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Detection of Copy Number Imbalance in Canine Urothelial Carcinoma With Droplet Digital Polymerase Chain Reaction
VETERINARY PATHOLOGY, 53(4), 764–772.
Contributors: n , S. Shapiro n & M. Breen n
author keywords: comparative genomic hybridization; cytogenetics; dogs; molecular diagnostic; transitional cell carcinoma; polymerase chain reaction; urinary bladder; urothelial carcinoma
MeSH headings : Animals; Carcinoma, Transitional Cell / diagnosis; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / pathology; Carcinoma, Transitional Cell / veterinary; Comparative Genomic Hybridization / veterinary; DNA Copy Number Variations; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Polymerase Chain Reaction / veterinary; Urinary Bladder / pathology; Urinary Bladder Neoplasms / diagnosis; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / pathology; Urinary Bladder Neoplasms / veterinary; Urologic Neoplasms / diagnosis; Urologic Neoplasms / genetics; Urologic Neoplasms / pathology; Urologic Neoplasms / veterinary
TL;DR:
The findings show that ddPCR is a useful molecular technique to detect CNAs and may be used as a noninvasive molecular diagnostic test for canine UC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Demonstration of the Cell Clonality in Canine Hematopoietic Tumors by X-chromosome Inactivation Pattern Analysis
Veterinary Pathology, 52(1), 61–69.
Contributors: * , Y. Goto-Koshino *, M. Takahashi *, Y. Fujino *, K. Ohno * & H. Tsujimoto *
MeSH headings : Animals; Biomarkers, Tumor / metabolism; Clone Cells; Dogs; Female; Hematologic Neoplasms / genetics; Hematologic Neoplasms / pathology; Hematologic Neoplasms / veterinary; Heterozygote; Humans; Leukemia / genetics; Leukemia / pathology; Leukemia / veterinary; Lymphoma / genetics; Lymphoma / pathology; Lymphoma / veterinary; Male; Polymorphism, Genetic / genetics; X Chromosome Inactivation
TL;DR:
XCIP analysis was successfully employed to demonstrate the cell clonality of canine hematopoietic tumors in this study and will be applicable to evaluate theClonality in various proliferative disorders in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2014 journal article
Hypermethylation of the death-associated protein kinase CpG island in canine B-cell lymphoid tumors
Veterinary Immunology and Immunopathology, 161(3-4), 222–231.
Contributors: M. Sato *, * , Y. Goto-Koshino *, A. Fujiwara-Igarashi *, M. Takahashi *, Y. Fujino*, K. Ohno *, H. Tsujimoto *
MeSH headings : Alkynes; Amino Acid Sequence; Animals; Cloning, Molecular; CpG Islands / physiology; Death-Associated Protein Kinases / genetics; Death-Associated Protein Kinases / metabolism; Dog Diseases / metabolism; Dogs; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / veterinary; Molecular Sequence Data
TL;DR:
DAPK was inactivated through hypermethylation of its CpG island in canine B-cell lymphoid tumor cells and this study will lead to the use of dogs with various lymphoid tumors as an animal model to evaluate the efficacy of demethylating agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2014 journal article
Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cells
Research in Veterinary Science, 97(1), 60–63.
Contributors: A. Fujiwara-Igarashi *, Y. Goto-Koshino *, * , M. Sato *, Y. Fujino*, K. Ohno *, H. Tsujimoto *
MeSH headings : Animals; Azacitidine / pharmacology; Base Sequence; Cell Line, Tumor; CpG Islands / genetics; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Methylation; DNA Primers / genetics; Dog Diseases / genetics; Dogs; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Genes, Tumor Suppressor; Lymphoma / genetics; Lymphoma / veterinary; Molecular Sequence Data; Promoter Regions, Genetic / genetics
TL;DR:
This study revealed the inactivation of p16 gene through hypermethylation of its CpG island in a fraction of canine lymphoid tumor cells.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2013 journal article
Chronic myelogenous leukaemia with persistent neutrophilia, eosinophilia and basophilia in a cat
Journal of Feline Medicine and Surgery, 16(6), 517–521.
Contributors: * , T. Seki *, Y. Nakahara*, A. Tomita*, M. Takahashi *, Y. Fujino*, K. Ohno *, H. Tsujimoto *
MeSH headings : Animals; Basophils; Cat Diseases / pathology; Cat Diseases / therapy; Cats; Eosinophilia / complications; Eosinophilia / pathology; Eosinophilia / veterinary; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / veterinary; Leukocyte Count / veterinary; Male; Remission Induction; Treatment Outcome
TL;DR:
The cat was still in good physical condition 63 months after diagnosis, despite the persistence of marked neutrophilia, eosinophilia and basophilia, and the severe leukocytosis did not respond to antibiotic therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2013 journal article
Simultaneous Inactivation of the p16, p15 and p14 Genes Encoding Cyclin-Dependent Kinase Inhibitors in Canine T-Lymphoid Tumor Cells
Journal of Veterinary Medical Science, 75(6), 733–742.
Contributors: A. Fujiwara-Igarashi *, Y. Goto-Koshino *, * , S. Maeda *, Y. Fujino*, K. Ohno *, H. Tsujimoto *
MeSH headings : Amino Acid Sequence; Animals; Cell Line, Tumor; Cloning, Molecular; Cyclin-Dependent Kinase Inhibitor Proteins / genetics; Cyclin-Dependent Kinase Inhibitor Proteins / metabolism; DNA, Complementary / genetics; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Gene Expression Regulation, Neoplastic / physiology; Lymphocytes / metabolism; Lymphoma / metabolism; Lymphoma / veterinary; Molecular Sequence Data; Mutation; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
The p16, p15 and p14 genes are widely known as tumor suppressor genes in human medicine and wide-ranging deletions in the p15-p14-p16 genomic locus could be one of the molecular aberrations in canine lymphoid tumor cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2012 journal article
Comparison of the antitumor effects of an MDM2 inhibitor, nutlin-3, in feline lymphoma cell lines with or without p53 mutation
Veterinary Immunology and Immunopathology, 147(3-4), 187–194.
Contributors: * , Y. Goto-Koshino *, M. Sato *, Y. Fujino*, K. Ohno * & H. Tsujimoto *
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Base Sequence; Cat Diseases / drug therapy; Cat Diseases / genetics; Cat Diseases / metabolism; Cat Diseases / pathology; Cats; Cell Cycle Checkpoints / drug effects; Cell Line, Tumor; DNA, Neoplasm / genetics; Genes, p53; Humans; Imidazoles / pharmacology; Lymphoma / drug therapy; Lymphoma / genetics; Lymphoma / metabolism; Lymphoma / veterinary; Mutation; Piperazines / pharmacology; Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors; Tumor Suppressor Protein p53 / metabolism
TL;DR:
It is concluded that nutlin-3 has an antitumor effect on feline lymphoma cell lines harboring the wt-p53 gene through accumulation and activation of P53 leading to cell cycle arrest and apoptosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2012 journal article
X-Chromosome Inactivation Pattern Analysis for the Assessment of Cell Clonality in Cats
Veterinary Pathology, 49(6), 963–970.
Contributors: * , Y. Goto-Koshino *, M. Takahashi *, Y. Fujino *, K. Ohno * & H. Tsujimoto *
MeSH headings : Animals; Biopsy, Needle / veterinary; Bone Marrow / pathology; Cat Diseases / genetics; Cat Diseases / pathology; Cats; Cell Line, Tumor; DNA / genetics; Exons / genetics; Female; Heterozygote; Male; Myelodysplastic Syndromes / genetics; Myelodysplastic Syndromes / pathology; Myelodysplastic Syndromes / veterinary; Neoplasms / genetics; Neoplasms / veterinary; Polymerase Chain Reaction / veterinary; Polymorphism, Genetic / genetics; Receptors, Androgen / genetics; Reproducibility of Results; Sensitivity and Specificity; Sequence Analysis, DNA / veterinary; Tandem Repeat Sequences / genetics; X Chromosome Inactivation / genetics
TL;DR:
The polymerase chain reaction–based feline XCIP analysis developed in this study can provide information on cell clonality in female cats, potentially facilitating the differential diagnosis of various disorders in cats.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2011 journal article
A Rapid and Simple Method to Obtain Canine Peripheral Blood-Derived Macrophages
Journal of Veterinary Medical Science, 73(6), 773–778.
Contributors: Y. Goto-Koshino *, K. Ohno *, M. Nakajima*, * , H. Kanemoto* & H. Tsujimoto *
MeSH headings : Animals; Cell Culture Techniques / methods; Cell Culture Techniques / veterinary; Dogs / blood; Dogs / immunology; Flow Cytometry / veterinary; Histocytochemistry; Immunophenotyping / veterinary; Leukocytes, Mononuclear / cytology; Macrophages / cytology; Macrophages / immunology; Phagocytosis / immunology
TL;DR:
This method facilitates a high yield of macrophages in a short cultivation period compared with previous studies, and might be a powerful tool to study macrophage functions in dogs.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2011 journal article
Establishment of a novel feline leukemia virus (FeLV)-negative B-cell cell line from a cat with B-cell lymphoma
Veterinary Immunology and Immunopathology, 140(3-4), 307–311.
Contributors: * , M. Takahashi *, K. Nishigaki *, T. Ide*, Y. Goto-Koshino *, S. Watanabe *, H. Sato *, M. Sato *
MeSH headings : Animals; B-Lymphocytes / immunology; B-Lymphocytes / virology; Base Sequence; Cat Diseases / genetics; Cat Diseases / immunology; Cat Diseases / virology; Cats; Cell Line, Tumor; DNA, Viral / genetics; DNA, Viral / isolation & purification; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Immunophenotyping; Leukemia Virus, Feline / genetics; Leukemia Virus, Feline / isolation & purification; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / veterinary; Lymphoma, B-Cell / virology; Male
TL;DR:
The MS4 cell line is the first FeLV-negative feline B-cell lymphoma cell line, and may be used to investigate the pathogenesis of spontaneously occurring feline lymphoma and the development of new therapies.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2011 journal article
Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma
Veterinary Journal, 191(1), 108–114.
Contributors: M. Sato *, H. Kanemoto, Y. Kagawa, T. Kobayashi, Y. Goto-Koshino, * , M. Takahashi, Y. Fujino, K. Ohno, H. Tsujimoto
MeSH headings : Animals; Disease-Free Survival; Dog Diseases / genetics; Dog Diseases / mortality; Dog Diseases / pathology; Dogs; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / mortality; Lymphoma, B-Cell / veterinary; Male; Neoplasm Recurrence, Local / genetics; Neoplasm Recurrence, Local / mortality; Neoplasm Recurrence, Local / veterinary; Neoplasm Staging; Prognosis; Proto-Oncogene Proteins c-bcl-6 / genetics; RNA, Messenger / analysis
TL;DR:
Most canine high-grade B-cell lymphomas correspond to human diffuse large B- cell lymphoma with no immunohistochemical expression of BCL6, according to the updated Kiel classification.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2011 journal article
GeneScan analysis to detect clonality of T-cell receptor gamma gene rearrangement in feline lymphoid neoplasms
Veterinary Immunology and Immunopathology, 145(1-2), 402–409.
Contributors: * , K. Nakamura*, H. Sato *, Y. Goto-Koshino *, M. Sato *, M. Takahashi *, K. Fukushima *, K. Nakashima *
MeSH headings : Animals; Cat Diseases / genetics; Cat Diseases / immunology; Cats; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel / veterinary; Female; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / genetics; Heteroduplex Analysis / veterinary; Lymphocytes / immunology; Lymphocytes / metabolism; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / genetics; Lymphoma, T-Cell / immunology; Lymphoma, T-Cell / veterinary; Male; Polymerase Chain Reaction / veterinary
TL;DR:
The PCR assay system to detect clonal TCRγ gene rearrangement in feline lymphoid cells, using GeneScan analysis, would be a useful molecular diagnostic tool for feline T-cell neoplasms, with high fidelity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2011 journal article
Multiplex PCR and Genescan analysis to detect immunoglobulin heavy chain gene rearrangement in feline B-cell neoplasms
Veterinary Immunology and Immunopathology, 143(1-2), 38–45.
Contributors: * , K. Nakamura*, H. Sato *, Y. Goto-Koshino *, M. Sato *, M. Takahashi *, Y. Fujino*, K. Ohno *
MeSH headings : Animals; Base Sequence; Cat Diseases / genetics; Cat Diseases / immunology; Cats; Cloning, Molecular; Complementarity Determining Regions; DNA Primers / genetics; DNA, Complementary / genetics; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Leukemia, B-Cell / genetics; Leukemia, B-Cell / immunology; Leukemia, B-Cell / veterinary; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / veterinary; Multiplex Polymerase Chain Reaction; Polymerase Chain Reaction / methods
TL;DR:
The multiplex PCR-based assay and Genescan analysis developed in the present study would be useful and practical tools to detect clonal IGHV gene rearrangement in feline B-cell neoplasms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2011 journal article
Perfusion method for harvesting bone marrow cells from dogs
American Journal of Veterinary Research, 72(10), 1344–1348. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000295390000007&KeyUID=WOS:000295390000007
Source: ORCID
Added: May 23, 2023
2010 journal article
Characterization of canine BCL6 cDNA and detection systems for its protein expression
Veterinary Immunology and Immunopathology, 140(1-2), 166–169.
Contributors: M. Sato *, Y. Goto-Koshino *, H. Kanemoto*, * , Y. Fujino*, K. Ohno *, H. Tsujimoto *
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cloning, Molecular; DNA, Complementary; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / genetics; Dogs / genetics; Dogs / immunology; Germinal Center / immunology; Immunoblotting / veterinary; Molecular Sequence Data
TL;DR:
The deduced amino acid sequence of canine BCL 6 showed close homology to that of human BCL6 (96.3%), especially in the zinc-finger motifs and POZ (poxvirus and zinc finger) domain with complete identity.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
Employment
Updated: November 1st, 2024 16:03
2024 - present
The University of Tennessee Knoxville, TN, US
Assistant Professor of Veterinary Clinical Pathology
Biomedical and Diagnostic
2021 - 2024
North Carolina State University Raleigh, US
Assistant Professor of Veterinary Clinical Pathology
Population Health and Pathobiology
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