Works (11)

Updated: April 23rd, 2024 05:01

2024 article

A program for real-time surveillance of SARS-CoV-2 genetics

Brochu, H. N., Song, K., Zhang, Q., Zeng, Q., Shafi, A., Robinson, M., … Iyer, L. K. (2024, April 19).

By: H. Brochu, K. Song, Q. Zhang, Q. Zeng, A. Shafi, M. Robinson, J. Humphrey, B. Croy ...

Source: ORCID
Added: April 22, 2024

2024 article

Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques

Brochu, H. N., Smith, E., Jeong, S., Carlson, M., Hansen, S. G., Tisoncik-Go, J., … Peng, X. (2024, February 28).

By: H. Brochu n, E. Smith*, S. Jeong n, M. Carlson*, S. Hansen*, J. Tisoncik-Go*, L. Law*, L. Picker*, M. Gale*, X. Peng n

TL;DR: Findings indicate that changes in gut microbiomes are associated with RhCMV/SIV vaccine-induced protection and early host response to vaccination in rhesus macaques. (via Semantic Scholar)
Source: ORCID
Added: March 1, 2024

2022 article

Alternative splicing and genetic variation of MHC-E: Implications for rhesus cytomegalovirus-based vaccines

Brochu, H., Wang, R., Tollison, T., Pyo, C.-W., Thomas, A., Tseng, E., … Peng, X. (2022, June 14).

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: March 1, 2024

2022 journal article

Alternative splicing and genetic variation of mhc-e: implications for rhesus cytomegalovirus-based vaccines

COMMUNICATIONS BIOLOGY, 5(1).

By: H. Brochu n, R. Wang*, T. Tollison n, C. Pyo*, A. Thomas*, E. Tseng*, L. Law*, L. Picker* ...

MeSH headings : Animals; Humans; Alternative Splicing; Cytomegalovirus; Cytomegalovirus Vaccines; Genetic Variation; Macaca mulatta; Simian Immunodeficiency Virus; Histocompatibility Antigens Class I / genetics
TL;DR: Using long-read sequencing, 16 Mamu-E isoforms were identified and all MamU-E splicing junctions were detected among HLA-Eisoforms in humans and the presence of G2_LTR alleles was significantly associated with the lack of RhCMV/SIV vaccine protection. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 17, 2023

2022 journal article

Phylogeny-guided microbiome OTU-specific association test (POST)

MICROBIOME, 10(1).

By: C. Huang n, B. Callahan n, M. Wu*, S. Holloway n, H. Brochu n, W. Lu n, X. Peng n, J. Tzeng n

author keywords: Association test; Phylogenetic tree; Kernel machine regression
MeSH headings : Computational Biology / methods; Computer Simulation; Female; Humans; Infant, Newborn; Microbiota / genetics; Phylogeny; Premature Birth
TL;DR: This work proposes a local collapsing test called phylogeny-guided microbiome OTU-specific association test (POST), and develops a user friendly R package POSTm, which can enhance the selection performance of associated microbiome features by improving the overall true-positive and false-positive detection. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2022 journal article

Single-Cell-Based High-Throughput Ig and TCR Repertoire Sequencing Analysis in Rhesus Macaques

JOURNAL OF IMMUNOLOGY, 208(3), 762–771.

MeSH headings : Animals; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Immunoglobulins / genetics; Macaca mulatta; Receptors, Antigen, T-Cell, alpha-beta / genetics; Receptors, Antigen, T-Cell, gamma-delta / genetics; Single-Cell Analysis; T-Lymphocytes / immunology; Transcriptome / genetics; VDJ Exons / genetics
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 28, 2022

2021 journal article

Tumor Necrosis Factor Alpha-Induced Interleukin-1 Alpha Synthesis and Cell Death Is Increased in Mouse Epithelial Cells Infected With Chlamydia muridarum

JOURNAL OF INFECTIOUS DISEASES, 224, S47–S55.

By: U. Nagarajan*, C. Cho*, C. Gyorke*, S. Nagarajan*, J. Ezzell*, H. Brochu n, I. Huntress n, E. Harrell n, X. Peng n

author keywords: Chlamydia muridarum; IL-1 alpha; mouse epithelial cells; mouse model; TNF alpha
MeSH headings : Animals; Cell Death; Chlamydia Infections / immunology; Chlamydia Infections / metabolism; Chlamydia muridarum / immunology; Epithelial Cells; Female; Interleukin-1alpha / immunology; Interleukin-1alpha / metabolism; Mice; Mice, Inbred C57BL; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / metabolism
TL;DR: The results suggest TNFα and IL-1α enhance each other's downstream effects resulting in a hyperinflammatory response to chlamydial infection and propose that biologics targeting TNF-induced IL- 1α synthesis could be used to mitigate tissue damage during chlamYDial infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 13, 2021

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu n, K. Popowski n, M. Gracieux n, J. Cores n, K. Huang n, M. Hensley n ...

MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR: It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 23, 2020

2020 journal article

Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque through Long Read Transcriptome Sequencing

JOURNAL OF IMMUNOLOGY, 204(12), 3434–3444.

By: H. Brochu n, E. Tseng*, E. Smith*, M. Thomas*, A. Jones n, K. Diveley n, L. Law*, S. Hansen* ...

MeSH headings : Animals; High-Throughput Nucleotide Sequencing / methods; Humans; Immunoglobulins / genetics; Immunoglobulins / immunology; Macaca mulatta / genetics; Macaca mulatta / immunology; Receptors, Antigen, T-Cell / immunology; Transcriptome / genetics; Transcriptome / immunology
TL;DR: New rhesus-specific assays are designed that remove the need for primers conventionally targeting variable regions and allow single cell level Ig and TCR repertoire analysis, and the first complete reference set for the constant regions of all known isotypes and chain types of rhesu Ig andTCR repertoires is constructed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2019 journal article

Simultaneous profiling of sexually transmitted bacterial pathogens, microbiome, and concordant host response in cervical samples using whole transcriptome sequencing analysis

MICROBIAL CELL, 6(3), 177–183.

By: . Catherine M. O'Connell*, H. Brochu n, J. Girardi*, E. Harrell n, A. Jones n, T. Darville*, A. Sena*, X. Peng n

author keywords: RNA-seq; chlamydia; gonorrhea; natural infection; microbiome
TL;DR: It is suggested that total RNA profiling will advance understanding of the interplay of pathogen, host and microbiota during natural infection and may reveal novel, outcome-relevant biomarkers. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 18, 2019

2017 review

Elucidating the role of host long non-coding RNA during viral infection: Challenges and paths forward

[Review of ]. Vaccines, 5(4).

By: D. Lemler, H. Brochu, F. Yang, E. Harrell & X. Peng

Source: NC State University Libraries
Added: August 6, 2018

Employment

Updated: April 17th, 2024 07:50

2021 - present

LabCorp (United States) Portland, Oregon, US
Senior Bioinformatics Scientist

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