Hunter N. Bomba

Works (9)

Updated: July 5th, 2023 15:39

2020 article

Impact of composite scaffold degradation rate on neural stem cell persistence in the glioblastoma surgical resection cavity

Moore, K. M., Graham-Gurysh, E. G., Bomba, H. N., Murthy, A. B., Bachelder, E. M., Hingtgen, S. D., & Ainslie, K. M. (2020, March 13). Materials Science and Engineering C.

By: K. Moore  n, E. Graham-Gurysh *, H. Bomba*, A. Murthy *, E. Bachelder *, S. Hingtgen *, K. Ainslie  n

author keywords: Electrospinning; Acetalated dextran; Gelatin; Tumoricidal neural stem cell therapy; TRAIL
MeSH headings : Acetylation; Animals; Brain Neoplasms / pathology; Cell Line; Cell Survival; Cross-Linking Reagents / chemistry; Dextrans / chemistry; Female; Gelatin / chemistry; Glioblastoma / pathology; Mice, Nude; Neural Stem Cells / pathology; Temperature; Tissue Scaffolds / chemistry
topics (OpenAlex): Neurogenesis and neuroplasticity mechanisms; Nerve injury and regeneration; Bone Tissue Engineering Materials
TL;DR: Interestingly, scaffold degradation profile did not significantly impact NSC persistence, but persistence and long-term survival of NSCs was significantly greater for both scaffolds compared to DI, with scaffold implanted N SCs still detected by BLI at day 120 in most mice. (via Semantic Scholar)
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Source: Web Of Science
Added: May 8, 2020

2020 article

Personalized‐induced neural stem cell therapy: Generation, transplant, and safety in a large animal model

Bomba, H. N., Sheets, K. T., Valdivia, A., Khagi, S., Ruterbories, L., Mariani, C. L., … Hingtgen, S. D. (2020, July 1). Bioengineering & Translational Medicine.

By: H. Bomba*, K. Sheets*, A. Valdivia *, S. Khagi *, L. Ruterbories n, C. Mariani n , L. Borst n , D. Tokarz n, S. Hingtgen *

author keywords: glioblastoma; neural stem cells; stem cell delivery
topics (OpenAlex): Neurogenesis and neuroplasticity mechanisms; Cancer Research and Treatments; Mesenchymal stem cell research
TL;DR: This study generates the first canine‐induced neural stem cells (iNSCs) engineered to carry TNFα‐related apoptosis‐inducing ligand and thymidine kinase (TK), as well as magnetic resonance imaging (MRI) contrast agents for in vivo tracking. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020

2019 article

Cysteine-rich Proteins for Drug Delivery and Diagnosis

Yang, G., Lu, Y., Bomba, H. N., & Gu, Z. (2019, May 16). Current Medicinal Chemistry.

By: G. Yang *, Y. Lu n, H. Bomba n & Z. Gu n

author keywords: Cysteine-rich protein; drug delivery; cancer diagnostics; protein-based nanoparticle; hydrogel; biomedical material
MeSH headings : Animals; Biocompatible Materials / chemistry; Cysteine / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / methods; Gold / chemistry; Humans; Hydrogels / chemistry; Nanocomposites / chemistry; Nanoparticles / chemistry; Nanotechnology / methods; Neoplasms / diagnosis; Neoplasms / drug therapy; Proteins / chemistry
topics (OpenAlex): Nanocluster Synthesis and Applications; Peptidase Inhibition and Analysis; Nanoparticle-Based Drug Delivery
TL;DR: This review surveys cysteine-rich protein-based biomedical materials, including protein-metal nanohybrids, gold nanoparticle-protein agglomerates, protein- based nanoparticles, and hydrogels, with an emphasis on their preparation methods, especially those based on the cysteined residue-related reactions. (via Semantic Scholar)
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Source: Web Of Science
Added: June 17, 2019

2018 article

Topical and Transdermal Nanomedicines for Cancer Therapy

Ye, Y., Wang, J., Sun, W., Bomba, H. N., & Gu, Z. (2018, November 12). Bioanalysis.

By: Y. Ye n, J. Wang n, W. Sun n, H. Bomba n & Z. Gu n

topics (OpenAlex): Advancements in Transdermal Drug Delivery; Nanoparticle-Based Drug Delivery; Advanced Drug Delivery Systems
TL;DR: This chapter summarizes the principles and the recent innovations in the field of transdermal nanomedicine together with opportunities and challenges in clinical translation. (via Semantic Scholar)
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Source: Web Of Science
Added: October 26, 2020

2017 article

Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy

Hu, Q., Sun, W., Qian, C., Bomba, H. N., Xin, H., & Gu, Z. (2017, February 3). Advanced Materials.

By: Q. Hu n, W. Sun n, C. Qian n, H. Bomba n, H. Xin n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Biomimetic Materials / chemistry; Blood Vessels / drug effects; Blood Vessels / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cells, Cultured; Dextrans / chemistry; Drug Delivery Systems; Human Umbilical Vein Endothelial Cells / drug effects; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Mice, Nude; Microtubules / enzymology; Microtubules / metabolism; Nanostructures / chemistry; Neoplasm Transplantation; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / metabolism; Oligopeptides / chemistry; Paclitaxel / administration & dosage; Paclitaxel / pharmacokinetics; Tumor Necrosis Factor-alpha / chemistry; Tumor Necrosis Factor-alpha / pharmacokinetics
topics (OpenAlex): RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques; Nanoplatforms for cancer theranostics
TL;DR: A "relay drug delivery" system based on two distinct modules that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B that can accumulate at the tumor site by receiving the broadcasting signals generated by NCA is developed for amplifying active tumor targeting signal and enhancing antitumor therapy. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

Hu, Q., Qian, C., Sun, W., Wang, J., Chen, Z., Bomba, H. N., … Gu, Z. (2016, September 14). Advanced Materials.

By: Q. Hu n, C. Qian n, W. Sun n, J. Wang n, Z. Chen n, H. Bomba n, H. Xin n, Q. Shen *, Z. Gu n

MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacokinetics; Biomimetics; Blood Platelets / cytology; Bone and Bones / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Cellular Microenvironment; Disease Models, Animal; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Humans; Mice; Multiple Myeloma / complications; Multiple Myeloma / drug therapy; Multiple Myeloma / metabolism; Multiple Myeloma / pathology; Nanoparticles / chemistry; Thrombosis / complications; Thrombosis / drug therapy
topics (OpenAlex): Multiple Myeloma Research and Treatments; Dendrimers and Hyperbranched Polymers; Protein Degradation and Inhibitors
TL;DR: A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and Myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myelomas growth and simultaneously eradicating thrombus complication. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Mechanical Force-Triggered Drug Delivery

Zhang, Y., Yu, J., Bomba, H. N., Zhu, Y., & Gu, Z. (2016, September 29). Chemical Reviews, Vol. 116, pp. 12536–12563.

By: Y. Zhang n, J. Yu n, H. Bomba n, Y. Zhu n  & Z. Gu n

Contributors: Y. Zhang n, J. Yu n, H. Bomba n, Y. Zhu n  & Z. Gu n

MeSH headings : Animals; Drug Carriers / chemistry; Drug Carriers / pharmacology; Drug Delivery Systems / methods; Liposomes / chemistry; Liposomes / pharmacology; Magnetic Phenomena; Mechanical Phenomena; Microbubbles; Nanoparticles / chemistry; Ultrasonic Waves
topics (OpenAlex): Nanoparticle-Based Drug Delivery; 3D Printing in Biomedical Research; Hydrogels: synthesis, properties, applications
TL;DR: An overview of recent advances in mechanically activated DDS is provided and the opportunities and challenges regarding clinical translations are discussed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 article

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

Hu, Q., Sun, W., Lu, Y., Bomba, H. N., Ye, Y., Jiang, T., … Gu, Z. (2016, January 19). Nano Letters.

By: Q. Hu n, W. Sun n, Y. Lu n, H. Bomba n, Y. Ye n, T. Jiang *, A. Isaacson *, Z. Gu n

author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
topics (OpenAlex): Nanoplatforms for cancer theranostics; Nanoparticle-Based Drug Delivery; RNA Interference and Gene Delivery
TL;DR: Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor-related apoptosis inducing ligand and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Anticancer Platelet‐Mimicking Nanovehicles

Hu, Q., Sun, W., Qian, C., Wang, C., Bomba, H. N., & Gu, Z. (2015, September 29). Advanced Materials.

By: Q. Hu n, W. Sun n, C. Qian n, C. Wang n, H. Bomba n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Blood Platelets / cytology; Cell Line, Tumor; Cell Membrane / chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Humans; Intracellular Space / metabolism; Mice; Nanomedicine / methods; Nanostructures / chemistry; TNF-Related Apoptosis-Inducing Ligand / chemistry; TNF-Related Apoptosis-Inducing Ligand / metabolism
topics (OpenAlex): Extracellular vesicles in disease; Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics
TL;DR: A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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