Works (9)
Updated: July 5th, 2023 15:39
2021 journal article
Personalized-induced neural stem cell therapy: Generation, transplant, and safety in a large animal model
BIOENGINEERING & TRANSLATIONAL MEDICINE, 6(1).
author keywords: glioblastoma; neural stem cells; stem cell delivery
TL;DR:
This study generates the first canine‐induced neural stem cells (iNSCs) engineered to carry TNFα‐related apoptosis‐inducing ligand and thymidine kinase (TK), as well as magnetic resonance imaging (MRI) contrast agents for in vivo tracking.
(via Semantic Scholar)
aiche.onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020
2020 journal article
Impact of composite scaffold degradation rate on neural stem cell persistence in the glioblastoma surgical resection cavity
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 111.
author keywords: Electrospinning; Acetalated dextran; Gelatin; Tumoricidal neural stem cell therapy; TRAIL
MeSH headings : Acetylation; Animals; Brain Neoplasms / pathology; Cell Line; Cell Survival; Cross-Linking Reagents / chemistry; Dextrans / chemistry; Female; Gelatin / chemistry; Glioblastoma / pathology; Mice, Nude; Neural Stem Cells / pathology; Temperature; Tissue Scaffolds / chemistry
TL;DR:
Interestingly, scaffold degradation profile did not significantly impact NSC persistence, but persistence and long-term survival of NSCs was significantly greater for both scaffolds compared to DI, with scaffold implanted N SCs still detected by BLI at day 120 in most mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 8, 2020
2019 review
Cysteine-rich Proteins for Drug Delivery and Diagnosis
[Review of ]. CURRENT MEDICINAL CHEMISTRY, 26(8), 1377–1388.
author keywords: Cysteine-rich protein; drug delivery; cancer diagnostics; protein-based nanoparticle; hydrogel; biomedical material
MeSH headings : Animals; Biocompatible Materials / chemistry; Cysteine / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / methods; Gold / chemistry; Humans; Hydrogels / chemistry; Nanocomposites / chemistry; Nanoparticles / chemistry; Nanotechnology / methods; Neoplasms / diagnosis; Neoplasms / drug therapy; Proteins / chemistry
TL;DR:
This review surveys cysteine-rich protein-based biomedical materials, including protein-metal nanohybrids, gold nanoparticle-protein agglomerates, protein- based nanoparticles, and hydrogels, with an emphasis on their preparation methods, especially those based on the cysteined residue-related reactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 17, 2019
2019 article
Topical and Transdermal Nanomedicines for Cancer Therapy
NANOTHERANOSTICS FOR CANCER APPLICATIONS, Vol. 5, pp. 231–251.
TL;DR:
This chapter summarizes the principles and the recent innovations in the field of transdermal nanomedicine together with opportunities and challenges in clinical translation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 26, 2020
2017 journal article
Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy
ADVANCED MATERIALS, 29(13).
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Biomimetic Materials / chemistry; Blood Vessels / drug effects; Blood Vessels / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cells, Cultured; Dextrans / chemistry; Drug Delivery Systems; Human Umbilical Vein Endothelial Cells / drug effects; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Mice, Nude; Microtubules / enzymology; Microtubules / metabolism; Nanostructures / chemistry; Neoplasm Transplantation; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / metabolism; Oligopeptides / chemistry; Paclitaxel / administration & dosage; Paclitaxel / pharmacokinetics; Tumor Necrosis Factor-alpha / chemistry; Tumor Necrosis Factor-alpha / pharmacokinetics
TL;DR:
A "relay drug delivery" system based on two distinct modules that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B that can accumulate at the tumor site by receiving the broadcasting signals generated by NCA is developed for amplifying active tumor targeting signal and enhancing antitumor therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus
ADVANCED MATERIALS, 28(43), 9573-+.
MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacokinetics; Biomimetics; Blood Platelets / cytology; Bone and Bones / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Cellular Microenvironment; Disease Models, Animal; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Humans; Mice; Multiple Myeloma / complications; Multiple Myeloma / drug therapy; Multiple Myeloma / metabolism; Multiple Myeloma / pathology; Nanoparticles / chemistry; Thrombosis / complications; Thrombosis / drug therapy
TL;DR:
A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and Myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myelomas growth and simultaneously eradicating thrombus complication.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 review
Mechanical Force-Triggered Drug Delivery
[Review of ]. CHEMICAL REVIEWS, 116(19), 12536–12563.
MeSH headings : Animals; Drug Carriers / chemistry; Drug Carriers / pharmacology; Drug Delivery Systems / methods; Liposomes / chemistry; Liposomes / pharmacology; Magnetic Phenomena; Mechanical Phenomena; Microbubbles; Nanoparticles / chemistry; Ultrasonic Waves
TL;DR:
An overview of recent advances in mechanically activated DDS is provided and the opportunities and challenges regarding clinical translations are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots
NANO LETTERS, 16(2), 1118–1126.
author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
TL;DR:
Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor-related apoptosis inducing ligand and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Anticancer Platelet-Mimicking Nanovehicles
ADVANCED MATERIALS, 27(44), 7043-+.
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Blood Platelets / cytology; Cell Line, Tumor; Cell Membrane / chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Humans; Intracellular Space / metabolism; Mice; Nanomedicine / methods; Nanostructures / chemistry; TNF-Related Apoptosis-Inducing Ligand / chemistry; TNF-Related Apoptosis-Inducing Ligand / metabolism
TL;DR:
A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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