Heather Rose Shive

Works (16)

Updated: November 25th, 2024 07:13

2024 article

Profiling the cancer-prone microenvironment in a zebrafish model for MPNST

Cero, C., House, J. S., Verdi, V., Ferguson, J. L., Jima, D. D., Selmek, A. A., … Shive, H. R. (2024, November 7). Oncogene, Vol. 11.

By: C. Cero *, J. House* , V. Verdi *, J. Ferguson*, D. Jima n, A. Selmek*, O. Patania, J. Dwyer * ...

MeSH headings : Animals; Zebrafish / genetics; Tumor Microenvironment / genetics; Disease Models, Animal; Humans; Gene Expression Regulation, Neoplastic; Neurofibrosarcoma / genetics; Neurofibrosarcoma / pathology; Neurofibrosarcoma / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism; Transcriptome; Gene Expression Profiling; Cell Adhesion Molecules / genetics; Cell Adhesion Molecules / metabolism
topics (OpenAlex): Aquaculture disease management and microbiota; Cancer, Hypoxia, and Metabolism; Zebrafish Biomedical Research Applications
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10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 7, 2024

2022 article

brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury

Kouprianov, V. A., Selmek, A. A., Ferguson, J. L., Mo, X., & Shive, H. R. (2022, January 18). Scientific Reports.

By: V. Kouprianov, A. Selmek*, J. Ferguson n, X. Mo * & H. Shive*

MeSH headings : Animals; Zebrafish
topics (OpenAlex): CRISPR and Genetic Engineering; Pluripotent Stem Cells Research; Zebrafish Biomedical Research Applications
TL;DR: The altered cell behaviors identified in brca2-mutant embryonic and adult tissues, particularly in adult tissues at high risk for cancer, indicate that the effects of BRCA2 mutation on cellular phenotypes are both context- and tissue-dependent. (via Semantic Scholar)
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Source: Web Of Science
Added: February 7, 2022

2020 article

Pathologic Lesions of the Budgett Frog (Lepidobatrachus laevis), an Emerging Laboratory Animal Model

Womble, M. A., Lewbart, G. A., & Shive, H. R. (2020, April 1). Comparative Medicine, Vol. 70, pp. 239–247.

By: M. Womble n, G. Lewbart n  & H. Shive n

MeSH headings : Animal Experimentation; Animals; Anura; Developmental Biology; Female; Male; Models, Animal; Retrospective Studies
topics (OpenAlex): Amphibian and Reptile Biology; Aquaculture disease management and microbiota; Turtle Biology and Conservation
TL;DR: This retrospective analysis is the first description of histologic lesions identified in captive L. laevis populations, providing new insight into spontaneous disease processes occurring in this species for use in disease diagnosis and clinical management. (via Semantic Scholar)
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15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2020

2019 article

Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in a brca2-Mutant Zebrafish Model

Mensah, L., Ferguson, J. L., & Shive, H. R. (2019, February 26). Journal of Oncology.

By: L. Mensah  n, J. Ferguson n & H. Shive n

topics (OpenAlex): Microtubule and mitosis dynamics; Epigenetics and DNA Methylation; Cancer Genomics and Diagnostics; Reproductive Biology and Fertility
TL;DR: It is determined that combined brca2/tp53 mutations uniquely disrupt meiotic progression and that sex significantly influences ploidy outcome in zebrafish cancers, and evidence is provided to support a link between BRCA2 mutation, tumor diploidy, and poor survival outcome. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 25, 2019

2019 article

Sequential Immunofluorescence and Immunohistochemistry on Cryosectioned Zebrafish Embryos

Ferguson, J. L., & Shive, H. R. (2019, May 14). Journal of Visualized Experiments.

By: J. Ferguson n & H. Shive n

author keywords: Biology; Issue 147; Zebrafish; embryos; immunohistochemistry; immunofluorescence; colocalization; intercellular interaction
MeSH headings : Animals; Cryoultramicrotomy; Embryo, Nonmammalian / anatomy & histology; Immunohistochemistry; Zebrafish / anatomy & histology; Zebrafish / embryology
topics (OpenAlex): Physiological and biochemical adaptations; MicroRNA in disease regulation; Angiogenesis and VEGF in Cancer
TL;DR: The purpose of the method described herein is to perform sequential immunofluorescence and/or immunohistochemistry on individual cryosections derived from early-stage zebrafish embryos to achieve precise identification of protein expression at the single-cell level. (via Semantic Scholar)
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Source: Web Of Science
Added: June 24, 2019

2018 article

Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation

Schultz, L. E., Haltom, J. A., Almeida, M. P., Wierson, W. A., Solin, S. L., Weiss, T. J., … McGrail, M. (2018, June 1). Disease Models & Mechanisms.

By: L. Schultz*, J. Haltom *, M. Almeida *, W. Wierson *, S. Solin*, T. Weiss *, J. Helmer*, E. Sandquist *, H. Shive n, M. McGrail *

author keywords: Zebrafish; Rbbp4; Hdac1; RB1 embryonal oligoneural brain tumor; Epigenetic regulators; CRISPR somatic targeting; Neural progenitor
MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / pathology; Cell Proliferation / genetics; Cell Survival; Epigenesis, Genetic; Histone Deacetylase 1 / genetics; Histone Deacetylase 1 / metabolism; Neural Stem Cells / metabolism; Retinoblastoma Protein / genetics; Retinoblastoma Protein / metabolism; Retinoblastoma-Binding Protein 4 / genetics; Retinoblastoma-Binding Protein 4 / metabolism; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
topics (OpenAlex): Zebrafish Biomedical Research Applications; Epigenetics and DNA Methylation; Neurogenesis and neuroplasticity mechanisms
TL;DR: It is shown that chromatin remodelers that are overexpressed in a zebrafish model of RB1 mutant brain cancer are required for neural progenitor proliferation and survival, providing insight into potential mechanisms that drive tumor growth. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2018 personal communication

Lameness in a 3-year-old backyard chicken Response

By: E. Cohen , H. Shive, L. Borst  & S. Almeida

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Multiloculated solitary (unicameral) bone cyst in a young dog

Veterinary Clinical Pathology, 47(3), 484–488.

By: S. Roode n, H. Shive n, W. Hoorntje n, J. Bernard*, D. Stowe n , R. Pool*, C. Grindem n

author keywords: Canine; cytology; lytic; osseous; osteoclast; skeletal
MeSH headings : Animals; Bone Cysts / complications; Bone Cysts / diagnostic imaging; Bone Cysts / pathology; Bone Cysts / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Femur / diagnostic imaging; Femur / pathology; Lameness, Animal / etiology; Lameness, Animal / pathology; Radiography / veterinary
topics (OpenAlex): Bone Tumor Diagnosis and Treatments; Oral and Maxillofacial Pathology; Veterinary Oncology Research
TL;DR: A 20-month-old female spayed Staffordshire Terrier presented to the Orthopedic Surgery Service at North Carolina State University Veterinary Teaching Hospital for evaluation of a 6-week history of toe-touching to nonweight-bearing lameness, and amputation of the right hind limb was performed. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: October 16, 2018

2018 article

What Is Your Diagnosis?

Almeida, S. M. B., Shive, H. R., Harvey, J. B., Borst, L. B., & Cohen, E. B. (2018, January 10). Journal of the American Veterinary Medical Association, Vol. 252, pp. 173–175.

By: S. Almeida, H. Shive n, J. Harvey n, L. Borst n  & E. Cohen n 

Contributors: S. Bessauer Almeida, H. Shive n, J. Harvey n, L. Borst n  & E. Cohen n 

MeSH headings : Animals; Chickens; Diagnosis, Differential; Female; Hindlimb; Kidney Neoplasms / complications; Kidney Neoplasms / diagnostic imaging; Kidney Neoplasms / pathology; Kidney Neoplasms / veterinary; Lameness, Animal / diagnosis; Lameness, Animal / diagnostic imaging; Lameness, Animal / etiology; Marek Disease / complications; Marek Disease / diagnosis; Marek Disease / pathology; Muscular Atrophy / complications; Muscular Atrophy / diagnostic imaging; Muscular Atrophy / veterinary; Poultry Diseases / diagnosis; Poultry Diseases / diagnostic imaging; Poultry Diseases / etiology; Poultry Diseases / pathology; Radiography / veterinary; Sciatic Nerve / pathology; Ultrasonography / veterinary
topics (OpenAlex): Veterinary Orthopedics and Neurology
TL;DR: On clinical examination, the dog was bright, alert and responsive with a body weight of 17.2kg and a body condition score of 5/9 and the mucous membranes were pink and moist, with a capillary refill time of one second. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Oral transmucosal detomidine gel in New Zealand white rabbits (Oryctolagus cuniculus)

Journal of the American Association for Laboratory Animal Science, 56(4), 436–442.

By: M. Williams , C. Long, J. Durrant, G. McKeon, H. Shive, E. Griffith , K. Messenger, R. Fish

Source: NC State University Libraries
Added: August 6, 2018

2016 article

Histologic and Immunohistochemical Analyses of Soft Tissue Sarcomas From brca2-Mutant/tp53-Mutant Zebrafish Are Consistent With Neural Crest (Schwann Cell) Origin

White, L. A., Sexton, J. M., & Shive, H. R. (2016, November 23). Veterinary Pathology.

By: L. White n, J. Sexton* & H. Shive n

MeSH headings : Animals; BRCA2 Protein / genetics; BRCA2 Protein / metabolism; Biomarkers, Tumor; CD57 Antigens / genetics; CD57 Antigens / metabolism; Fish Diseases / pathology; Gene Expression Regulation, Neoplastic; Genotype; Glial Fibrillary Acidic Protein / genetics; Glial Fibrillary Acidic Protein / metabolism; Mutation; Neural Crest; Neurilemmoma / metabolism; S100 Proteins / genetics; S100 Proteins / metabolism; Sarcoma / etiology; Sarcoma / pathology; Sarcoma / veterinary; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
topics (OpenAlex): Neurofibromatosis and Schwannoma Cases; Sarcoma Diagnosis and Treatment; Neuroblastoma Research and Treatments
TL;DR: Commercial available antibodies that are useful for analyzing S100, CD57, and GFAP expression in zebrafish are identified and shows a correlation between degree of histologic differentiation and expression of these markers in soft tissue sarcomas from brca2-mutant/tp53-mutants zebra fish and suggests that these cancers are derived from the neural crest with differentiation toward myelinating Schwann cells. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2015 article

Expression ofKRASG12Vin Zebrafish Gills Induces Hyperplasia andCXCL8-Associated Inflammation

Shive, H. R., West, R. R., Embree, L. J., Sexton, J. M., & Hickstein, D. D. (2015, March 23). Zebrafish.

By: H. Shive*, R. West *, L. Embree*, J. Sexton* & D. Hickstein *

MeSH headings : Animals; Animals, Genetically Modified; Female; Gills / metabolism; Gills / pathology; Green Fluorescent Proteins; Hyperplasia; Inflammation / etiology; Inflammation / metabolism; Interleukin-8 / metabolism; MAP Kinase Signaling System; Male; Neoplasms, Experimental / etiology; Neoplasms, Experimental / metabolism; Oncogenes; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras) / genetics; Proto-Oncogene Proteins p21(ras) / metabolism; SOX9 Transcription Factor / metabolism; Somatomedins / metabolism; Zebrafish; Zebrafish Proteins / metabolism
topics (OpenAlex): Zebrafish Biomedical Research Applications; FOXO transcription factor regulation; Cytokine Signaling Pathways and Interactions
TL;DR: In transgenic zebrafish, expression of EGFP-KRASG12V driven by the igf3 promoter occurred only in the gills and resulted in proliferation of a putative progenitor cell population, chondroid hyperplasia, and localized inflammation. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Rapid tumor induction in zebrafish by TALEN-mediated somatic inactivation of the retinoblastoma1 tumor suppressor rb1

Solin, S. L., Shive, H. R., Woolard, K. D., Essner, J. J., & McGrail, M. (2015, September 8). Scientific Reports.

By: S. Solin*, H. Shive n, K. Woolard *, J. Essner * & M. McGrail *

MeSH headings : Alleles; Animals; Base Sequence; Brain Neoplasms / genetics; Brain Neoplasms / pathology; Cell Transformation, Neoplastic / genetics; Disease Models, Animal; Endonucleases / metabolism; Gene Frequency; Gene Silencing; Gene Targeting; Genetic Loci; Germ Cells / metabolism; Humans; Mitotic Index; Retinoblastoma Protein / chemistry; Retinoblastoma Protein / genetics; Sequence Alignment; Zebrafish
topics (OpenAlex): Zebrafish Biomedical Research Applications; CRISPR and Genetic Engineering; Epigenetics and DNA Methylation
TL;DR: This is the first demonstration that somatic inactivation of a tumor suppressor causes cancer in zebrafish and highlights the utility of site-specific nucleases to create genetic mosaic zebra fish for tumor suppressionor gene discovery. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 journal article

Long-Term Follow-up of Foamy Viral Vector-Mediated Gene Therapy for Canine Leukocyte Adhesion Deficiency

Molecular Therapy, 21(5), 964–972.

By: T. Bauer *, L. Tuschong*, K. Calvo *, H. Shive*, T. Burkholder*, E. Karlsson*, R. West *, D. Russell *, D. Hickstein *

MeSH headings : Animals; Antigens, CD34 / metabolism; Bone Marrow; CD18 Antigens / metabolism; Disease Models, Animal; Dogs; Female; Follow-Up Studies; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors / genetics; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / metabolism; Humans; Leukocyte Count; Leukocyte-Adhesion Deficiency Syndrome / genetics; Leukocyte-Adhesion Deficiency Syndrome / therapy; Leukocytes / metabolism; Male; Spumavirus / genetics; T-Lymphocyte Subsets / metabolism; Transduction, Genetic; Virus Integration
topics (OpenAlex): Virus-based gene therapy research; Animal Genetics and Reproduction; Virology and Viral Diseases
TL;DR: Results showing disease correction/amelioration of disease in CLAD without significant adverse events provide support for the use of a FV vector to treat children with leukocyte adhesion deficiency type 1 (LAD-1) in a human gene therapy clinical trial. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: June 6, 2020

2012 journal article

Proteomic Profiling of H-Ras-G12V Induced Hypertrophic Cardiomyopathy in Transgenic Mice Using Comparative LC-MS Analysis of Thin Fresh-Frozen Tissue Sections

Journal of Proteome Research, 11(3), 1561–1570.

By: B. Wei*, R. Simpson *, D. Johann*, J. Dwyer *, D. Prieto*, M. Kumar*, X. Ye *, B. Luke * ...

author keywords: H-Ras; hypertrophic cardiomyopathy; fresh frozen tissue; methanol-based solubilization/digestion; comparative proteomic profiling; pathway analysis; method development
MeSH headings : Amino Acid Sequence; Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / metabolism; Chromatography, Liquid; Cluster Analysis; Gene Expression; Gene Expression Regulation; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation, Missense; Myocardium / metabolism; Peptide Fragments / chemistry; Protein Precursors / chemistry; Protein Precursors / genetics; Protein Precursors / metabolism; Proteome / genetics; Proteome / metabolism; Proteomics; Proto-Oncogene Proteins p21(ras) / chemistry; Proto-Oncogene Proteins p21(ras) / genetics; Proto-Oncogene Proteins p21(ras) / metabolism; Vimentin / metabolism; Wnt3A Protein / metabolism; beta Catenin / metabolism
topics (OpenAlex): Cardiomyopathy and Myosin Studies; Peptidase Inhibition and Analysis; Protein Kinase Regulation and GTPase Signaling
TL;DR: Results indicate that the described proteomic approach permits molecular discovery and assessment of differentially expressed proteins regulating H-Ras induced hypertrophic cardiomyopathy. (via Semantic Scholar)
Source: Crossref
Added: June 6, 2020

2001 article

Simultaneous development of vocal and physical object combinations by a grey parrot (Psittaus erithacus): Bottle caps, lids, and labels.

Pepperberg, I. M., & Shive, H. R. (2001, January 1). Journal of Comparative Psychology.

By: I. Pepperberg * & H. Shive*

topics (OpenAlex): Animal Vocal Communication and Behavior; Child and Animal Learning Development; Language and cultural evolution
TL;DR: The authors found a comparable, if limited, parallel combinatorial development in a Grey parrot (Psittacus erithacus), and suggest that the search for and arguments concerning responsible substrates and common behavior should be approached with care and should not be restricted to the primate line. (via Semantic Scholar)
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4. Quality Education (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

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