Heather Rose Shive
Works (15)
Updated: July 21st, 2023 21:17
2022 journal article
brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Animals; Zebrafish
TL;DR:
The altered cell behaviors identified in brca2-mutant embryonic and adult tissues, particularly in adult tissues at high risk for cancer, indicate that the effects of BRCA2 mutation on cellular phenotypes are both context- and tissue-dependent.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 7, 2022
2020 journal article
Pathologic Lesions of the Budgett Frog (Lepidobatrachus laevis), an Emerging Laboratory Animal Model
COMPARATIVE MEDICINE, 70(3), 239–247.
MeSH headings : Animal Experimentation; Animals; Anura; Developmental Biology; Female; Male; Models, Animal; Retrospective Studies
TL;DR:
This retrospective analysis is the first description of histologic lesions identified in captive L. laevis populations, providing new insight into spontaneous disease processes occurring in this species for use in disease diagnosis and clinical management.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 26, 2020
2019 journal article
Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in a brca2-Mutant Zebrafish Model
JOURNAL OF ONCOLOGY, 2019.
TL;DR:
It is determined that combined brca2/tp53 mutations uniquely disrupt meiotic progression and that sex significantly influences ploidy outcome in zebrafish cancers, and evidence is provided to support a link between BRCA2 mutation, tumor diploidy, and poor survival outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 25, 2019
2019 journal article
Sequential Immunofluorescence and Immunohistochemistry on Cryosectioned Zebrafish Embryos
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (147).
author keywords: Biology; Issue 147; Zebrafish; embryos; immunohistochemistry; immunofluorescence; colocalization; intercellular interaction
MeSH headings : Animals; Cryoultramicrotomy; Embryo, Nonmammalian / anatomy & histology; Immunohistochemistry; Zebrafish / anatomy & histology; Zebrafish / embryology
TL;DR:
The purpose of the method described herein is to perform sequential immunofluorescence and/or immunohistochemistry on individual cryosections derived from early-stage zebrafish embryos to achieve precise identification of protein expression at the single-cell level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 24, 2019
2018 journal article
Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation
DISEASE MODELS & MECHANISMS, 11(6).
author keywords: Zebrafish; Rbbp4; Hdac1; RB1 embryonal oligoneural brain tumor; Epigenetic regulators; CRISPR somatic targeting; Neural progenitor
MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / pathology; Cell Proliferation / genetics; Cell Survival; Epigenesis, Genetic; Histone Deacetylase 1 / genetics; Histone Deacetylase 1 / metabolism; Neural Stem Cells / metabolism; Retinoblastoma Protein / genetics; Retinoblastoma Protein / metabolism; Retinoblastoma-Binding Protein 4 / genetics; Retinoblastoma-Binding Protein 4 / metabolism; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
It is shown that chromatin remodelers that are overexpressed in a zebrafish model of RB1 mutant brain cancer are required for neural progenitor proliferation and survival, providing insight into potential mechanisms that drive tumor growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 personal communication
Lameness in a 3-year-old backyard chicken Response
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Multiloculated solitary (unicameral) bone cyst in a young dog
Veterinary Clinical Pathology, 47(3), 484–488.
author keywords: Canine; cytology; lytic; osseous; osteoclast; skeletal
MeSH headings : Animals; Bone Cysts / complications; Bone Cysts / diagnostic imaging; Bone Cysts / pathology; Bone Cysts / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Femur / diagnostic imaging; Femur / pathology; Lameness, Animal / etiology; Lameness, Animal / pathology; Radiography / veterinary
TL;DR:
A 20-month-old female spayed Staffordshire Terrier presented to the Orthopedic Surgery Service at North Carolina State University Veterinary Teaching Hospital for evaluation of a 6-week history of toe-touching to nonweight-bearing lameness, and amputation of the right hind limb was performed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: October 16, 2018
2018 journal article
What is your diagnosis?
Journal of the American Veterinary Medical Association, 252(2), 173–175.
MeSH headings : Animals; Chickens; Diagnosis, Differential; Female; Hindlimb; Kidney Neoplasms / complications; Kidney Neoplasms / diagnostic imaging; Kidney Neoplasms / pathology; Kidney Neoplasms / veterinary; Lameness, Animal / diagnosis; Lameness, Animal / diagnostic imaging; Lameness, Animal / etiology; Marek Disease / complications; Marek Disease / diagnosis; Marek Disease / pathology; Muscular Atrophy / complications; Muscular Atrophy / diagnostic imaging; Muscular Atrophy / veterinary; Poultry Diseases / diagnosis; Poultry Diseases / diagnostic imaging; Poultry Diseases / etiology; Poultry Diseases / pathology; Radiography / veterinary; Sciatic Nerve / pathology; Ultrasonography / veterinary
TL;DR:
On clinical examination, the dog was bright, alert and responsive with a body weight of 17.2kg and a body condition score of 5/9 and the mucous membranes were pink and moist, with a capillary refill time of one second.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Histologic and immunohistochemical analyses of soft tissue sarcomas from brca2-mutant/tp53-mutant zebrafish are consistent with neural crest (Schwann Cell) origin
Veterinary Pathology, 54(2), 320–327.
MeSH headings : Animals; BRCA2 Protein / genetics; BRCA2 Protein / metabolism; Biomarkers, Tumor; CD57 Antigens / genetics; CD57 Antigens / metabolism; Fish Diseases / pathology; Gene Expression Regulation, Neoplastic; Genotype; Glial Fibrillary Acidic Protein / genetics; Glial Fibrillary Acidic Protein / metabolism; Mutation; Neural Crest; Neurilemmoma / metabolism; S100 Proteins / genetics; S100 Proteins / metabolism; Sarcoma / etiology; Sarcoma / pathology; Sarcoma / veterinary; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
Commercial available antibodies that are useful for analyzing S100, CD57, and GFAP expression in zebrafish are identified and shows a correlation between degree of histologic differentiation and expression of these markers in soft tissue sarcomas from brca2-mutant/tp53-mutants zebra fish and suggests that these cancers are derived from the neural crest with differentiation toward myelinating Schwann cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Oral transmucosal detomidine gel in New Zealand white rabbits (Oryctolagus cuniculus)
Journal of the American Association for Laboratory Animal Science, 56(4), 436–442.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Expression of KRAS(G12V) in Zebrafish Gills Induces Hyperplasia and CXCL8-Associated Inflammation
ZEBRAFISH, 12(3), 221–229.
MeSH headings : Animals; Animals, Genetically Modified; Female; Gills / metabolism; Gills / pathology; Green Fluorescent Proteins; Hyperplasia; Inflammation / etiology; Inflammation / metabolism; Interleukin-8 / metabolism; MAP Kinase Signaling System; Male; Neoplasms, Experimental / etiology; Neoplasms, Experimental / metabolism; Oncogenes; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras) / genetics; Proto-Oncogene Proteins p21(ras) / metabolism; SOX9 Transcription Factor / metabolism; Somatomedins / metabolism; Zebrafish; Zebrafish Proteins / metabolism
TL;DR:
In transgenic zebrafish, expression of EGFP-KRASG12V driven by the igf3 promoter occurred only in the gills and resulted in proliferation of a putative progenitor cell population, chondroid hyperplasia, and localized inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Rapid tumor induction in zebrafish by TALEN-mediated somatic inactivation of the retinoblastoma1 tumor suppressor rb1
SCIENTIFIC REPORTS, 5.
MeSH headings : Alleles; Animals; Base Sequence; Brain Neoplasms / genetics; Brain Neoplasms / pathology; Cell Transformation, Neoplastic / genetics; Disease Models, Animal; Endonucleases / metabolism; Gene Frequency; Gene Silencing; Gene Targeting; Genetic Loci; Germ Cells / metabolism; Humans; Mitotic Index; Retinoblastoma Protein / chemistry; Retinoblastoma Protein / genetics; Sequence Alignment; Zebrafish
TL;DR:
This is the first demonstration that somatic inactivation of a tumor suppressor causes cancer in zebrafish and highlights the utility of site-specific nucleases to create genetic mosaic zebra fish for tumor suppressionor gene discovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Long-Term Follow-up of Foamy Viral Vector-Mediated Gene Therapy for Canine Leukocyte Adhesion Deficiency
Molecular Therapy, 21(5), 964–972.
MeSH headings : Animals; Antigens, CD34 / metabolism; Bone Marrow; CD18 Antigens / metabolism; Disease Models, Animal; Dogs; Female; Follow-Up Studies; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors / genetics; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / metabolism; Humans; Leukocyte Count; Leukocyte-Adhesion Deficiency Syndrome / genetics; Leukocyte-Adhesion Deficiency Syndrome / therapy; Leukocytes / metabolism; Male; Spumavirus / genetics; T-Lymphocyte Subsets / metabolism; Transduction, Genetic; Virus Integration
TL;DR:
Results showing disease correction/amelioration of disease in CLAD without significant adverse events provide support for the use of a FV vector to treat children with leukocyte adhesion deficiency type 1 (LAD-1) in a human gene therapy clinical trial.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: June 6, 2020
2012 journal article
Proteomic Profiling of H-Ras-G12V Induced Hypertrophic Cardiomyopathy in Transgenic Mice Using Comparative LC-MS Analysis of Thin Fresh-Frozen Tissue Sections
Journal of Proteome Research, 11(3), 1561–1570.
author keywords: H-Ras; hypertrophic cardiomyopathy; fresh frozen tissue; methanol-based solubilization/digestion; comparative proteomic profiling; pathway analysis; method development
MeSH headings : Amino Acid Sequence; Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / metabolism; Chromatography, Liquid; Cluster Analysis; Gene Expression; Gene Expression Regulation; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation, Missense; Myocardium / metabolism; Peptide Fragments / chemistry; Protein Precursors / chemistry; Protein Precursors / genetics; Protein Precursors / metabolism; Proteome / genetics; Proteome / metabolism; Proteomics; Proto-Oncogene Proteins p21(ras) / chemistry; Proto-Oncogene Proteins p21(ras) / genetics; Proto-Oncogene Proteins p21(ras) / metabolism; Vimentin / metabolism; Wnt3A Protein / metabolism; beta Catenin / metabolism
TL;DR:
Results indicate that the described proteomic approach permits molecular discovery and assessment of differentially expressed proteins regulating H-Ras induced hypertrophic cardiomyopathy.
(via Semantic Scholar)
Source: Crossref
Added: June 6, 2020
2001 journal article
Simultaneous development of vocal and physical object combinations by a grey parrot (Psittacus erithacus): Bottle caps, lids, and labels
Journal of Comparative Pathology, 115(4), 376–384.
TL;DR:
The authors found a comparable, if limited, parallel combinatorial development in a Grey parrot (Psittacus erithacus), and suggest that the search for and arguments concerning responsible substrates and common behavior should be approached with care and should not be restricted to the primate line.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
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